2021/10/20 更新

写真a

デグチ ヒロユキ
出口 浩之
DEGUCHI Hiroyuki
所属
医歯学総合病院 麻酔科 助教
職名
助教
外部リンク

代表的な業績

学位

  • 医学博士 ( 2021年3月   新潟大学 )

研究キーワード

  • 運動誘発電位

研究分野

  • ライフサイエンス / 麻酔科学

経歴

  • 新潟大学   医歯学総合病院 麻酔科   助教

    2020年4月 - 現在

 

論文

  • Propofol reduces the amplitude of transcranial electrical motor-evoked potential without affecting spinal motor neurons: a prospective, single-arm, interventional study.

    Hiroyuki Deguchi, Kenta Furutani, Yusuke Mitsuma, Yoshinori Kamiya, Hiroshi Baba

    Journal of anesthesia   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: Propofol inhibits the amplitudes of transcranial electrical motor-evoked potentials (TCE-MEP) in a dose-dependent manner. However, the mechanisms of this effect remain unknown. Hence, we investigated the spinal mechanisms of the inhibitory effect of propofol on TCE-MEP amplitudes by evaluating evoked electromyograms (H-reflex and F-wave) under general anesthesia. METHODS: We conducted a prospective, single-arm, interventional study including 15 patients scheduled for spine surgery under general anesthesia. Evoked electromyograms of the soleus muscle and TCE-MEPs were measured at three propofol concentrations using target-controlled infusion (TCI: 2.0, 3.0, and 4.0 µg/mL). The primary outcome measure was the left H-reflex amplitude during TCI of 4.0- compared to 2.0-µg/mL propofol administration. RESULTS: The median [interquartile range] amplitudes of the left H-reflex were 4.71 [3.42-6.60] and 5.6 [4.17-7.46] in the 4.0- and 2.0-μg/mL TCI groups (p = 0.4, Friedman test), respectively. There were no significant differences in the amplitudes of the right H-reflex and the bilateral F-wave among these groups. However, the TCE-MEP amplitudes significantly decreased with increased propofol concentrations (p < 0.001, Friedman test). CONCLUSION: Propofol did not affect the amplitudes of the H-reflex and the F-wave, whereas TCE-MEP amplitudes were reduced at higher propofol concentrations. These results suggested that propofol can suppress the TCE-MEP amplitude by inhibiting the supraspinal motor pathways more strongly than the excitability of the motor neurons in the spinal cord.

    DOI: 10.1007/s00540-021-02927-7

    PubMed

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  • Low-dose droperidol suppresses transcranial electrical motor-evoked potential amplitude: a retrospective study

    Hiroyuki Deguchi, Kenta Furutani, Yusuke Mitsuma, Yoshinori Kamiya, Hiroshi Baba

    Journal of Clinical Monitoring and Computing   2020年2月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/s10877-020-00464-4

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    その他リンク: http://link.springer.com/article/10.1007/s10877-020-00464-4/fulltext.html