2025/04/06 更新

写真a

ハセガワ　エリコ
長谷川　絵理子
HASEGAWA Eriko
所属
医歯学総合病院 腎・膠原病内科 助教
職名
助教
外部リンク

学位

  • 博士(医学) （ 2019年3月 ）

経歴

  • 新潟大学   医歯学総合病院　腎・膠原病内科   助教

    2020年4月 - 現在

 

論文

  • Pathogenetic associations of anti-ribosomal P protein antibody titres and its subclasses in patients with systemic lupus erythematosus

    Yoshikatsu Kaneko, Hiroe Sato, Ayako Wakamatsu, Daisuke Kobayashi, Kaho Sato, Yoichi Kurosawa, Eriko Hasegawa, Takeshi Nakatsue, Takeshi Kuroda, Ichiei Narita

    Rheumatology   2023年8月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Oxford University Press (OUP)  

    Abstract

    Objectives

    We evaluated the association between anti-ribosomal P antibody (anti-RibP) titres and disease activity in Japanese systemic lupus erythematosus (SLE) patients.

    Methods

    Eighty patients admitted and treated in Niigata University Hospital for new-onset or flare-up of SLE were included in this retrospective cross-sectional study. Clinical data were obtained from medical records at admission. Anti-RibP index, and cytokine and tryptophan metabolite levels were determined by ELISA.

    Results

    Of the 80 SLE patients, 30 had anti-RibP. Anti-RibP presence was associated with a greater prevalence of skin rash and more severe inflammatory responses, demonstrated by higher inflammatory cytokine levels, hypocomplementemia, and accelerated tryptophan metabolism, in younger patients. The serum anti-RibP index correlated with age at diagnosis, clinical indicators, initial prednisolone dose, and cytokines and tryptophan metabolite levels in univariate analysis. Multivariate analysis showed the anti-RibP index was independently associated with initial prednisolone dose and prevalence of skin rash. Anti-RibP IgG were mainly IgG2 and IgG3 subclasses, and anti-RibP IgG3 was associated with hypocomplementemia, higher disease activity score, accelerated kynurenine pathway activity, and higher proinflammatory cytokine production. The coexistence of anti-dsDNA IgG and anti-RibP IgG2 or IgG3 accompanied higher IL-10 and IFN-α2 levels; furthermore, anti-RibP IgG3 coexistence with anti-dsDNA antibody contributed to the requirement for higher initial prednisolone doses and accelerated kynurenine pathway activity.

    Conclusion

    Anti-RibP was associated with clinical manifestations and parameters in SLE, and its index might be a useful indicator of disease severity. Anti-RibP IgG3 was the IgG subclass most strongly associated with the pathogenesis of SLE.

    DOI： 10.1093/rheumatology/kead402

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  • The Risks of Femoral Localized Periosteal Thickening in Patients with Autoimmune Inflammatory Rheumatic Diseases. 国際誌

    Hiroe Sato, Naoki Kondo, Chinatsu Takai, Yoichi Kurosawa, Eriko Hasegawa, Ayako Wakamatsu, Daisuke Kobayashi, Takeshi Nakatsue, Asami Abe, Junichiro James Kazama, Takeshi Kuroda, Satoshi Ito, Hajime Ishikawa, Naoto Endo, Ichiei Narita

    Modern rheumatology   2022年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    PURPOSE: The incidence of femoral localized periosteal thickening (LPT), which can precede atypical femoral fracture (AFF), is not low (1-10%) in Japanese patients with autoimmune inflammatory rheumatic diseases (AIRDs). We explored the associations between underlying AIRDs and the prevalence of LPT. METHODS: We conducted post-hoc analyses of two cohorts that included a total of 280 Japanese women, 105 of whom had AIRDs and had been taking bisphosphonate (BP) and prednisolone (PSL), and 175 of whom had rheumatoid arthritis (RA). RESULTS: LPT was detected in a total of 18 patients (6.4%) and three (1.1%) developed AFFs. RA was negatively correlated with LPT. A disease other than RA requiring glucocorticoid treatment, BP use ≥ 5 years, PSL use ≥ 7 years, and a PSL dose ≥ 5.5 mg/day were positively correlated with LPT. After adjusting for age, diabetes mellitus, and BP duration or daily PSL dose, RA was no longer associated with LPT. CONCLUSION: LPT in Japanese patients with AIRDs was associated with BP and glucocorticoid treatment rather than underlying AIRDs. When a PSL dose ≥ 5.5 mg/day is required long-term (typically combined with long-term BP treatment [≥ 5 years]), clinicians need to pay particular attention in case LPT and AFF, as well as glucocorticoid-induced osteoporosis.

    DOI： 10.1093/mr/roac062

    PubMed

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  • Lower trabecular bone score is associated with an increased incidence of localized femoral periosteal thickening.

    Hiroe Sato, Naoki Kondo, Yoichi Kurosawa, Eriko Hasegawa, Ayako Wakamatsu, Daisuke Kobayashi, Takeshi Nakatsue, Junichiro James Kazama, Takeshi Kuroda, Yoshiki Suzuki, Naoto Endo, Ichiei Narita

    Journal of bone and mineral metabolism   39 ( 6 )   952 - 961   2021年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    INTRODUCTION: Femoral localized periosteal thickening (LPT, also termed "beaking") of the lateral cortex often precedes an atypical femoral fracture (AFF). Bisphosphonate (BP) use, glucocorticoid use, and Asian race are major risk factors for developing such fractures. The aim of this study was to determine whether the trabecular bone score (TBS) reflecting the lumbar trabecular microarchitecture was related to LPT in glucocorticoid-treated Japanese patients with autoimmune diseases. MATERIALS AND METHODS: We retrospectively investigated 111 women with autoimmune diseases treated with prednisolone (PSL) who had undergone both femoral X-ray and dual-energy X-ray absorptiometry of the L1 - L4 lumbar vertebrae and for whom TBS could be evaluated for two or more of these. RESULTS: Femoral LPT was evident in the X-rays of 18 of 111 patients (16.2%). Higher body mass index (BMI), longer duration of PSL use and longer duration of BP use were significant in patients with LPT compared to those without. The TBS was significantly lower in patients with LPT than in those without (1.314 ± 0.092 vs. 1.365 ± 0.100, p = 0.044); however, the lumbar bone mineral density did not differ significantly (0.892 ± 0.141 vs. 0.897 ± 0.154 g/cm2, p = 0.897). TBS was significantly associated with LPT (odds ratio, 0.004; 95% CI, 0 - 0.96; p = 0.048), but not in the multivariate analysis including BMI, duration of PSL use and duration of BP use. CONCLUSIONS: The TBS was lower in glucocorticoid-treated Japanese women with autoimmune diseases with LPT than in those without LPT, and deteriorated trabecular microarchitecture influenced by longer use of BP and glucocorticoid might be associated with the development of LPT.

    DOI： 10.1007/s00774-021-01244-z

    PubMed

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  • 慢性腎臓病を合併した関節リウマチ患者における持続性エリスロポエチン受容体活性化因子の有効性(The effectiveness of continuous erythropoietin receptor activator in rheumatoid arthritis patients with chronic kidney disease)

    伊藤 聡, 岡林 諒, 阿部 麻美, 大谷 博, 中園 清, 村澤 章, 石川 肇, 長谷川 絵理子, 小林 大介, 成田 一衛, 坂井 俊介, 黒澤 陽一

    臨床リウマチ   33 ( 3 )   233 - 245   2021年9月

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    記述言語：英語   出版者・発行元：(一社)日本臨床リウマチ学会  

    目的:慢性腎臓病(CKD)を合併した関節リウマチ(RA)患者における持続性エリスロポエチン受容体活性化剤(CERA)の有用性の検討。方法:CERAを使用した37例のRA患者のうち、11例は12ヵ月以内に死亡していた。12ヵ月以上CERAを使用した26例(男性2例、女性24例)について有用性を検討した。結果:患者年齢は77.4±7.0歳、罹病期間は17.9±14.5年であった。血液尿素窒素25.8±10.6mg/dl、血清クレアチニン(Cr)は1.2±0.5mg/dl、推算糸球体濾過量は41.6±16.0ml/min/1.73m2であった。血清鉄やフェリチンの低下はなく、不飽和鉄結合能は上昇しておらず、平均赤血球容積の低下は認めなかった。血清エリスロポエチンの上昇は認めなかった。CERAの使用により(43.1±21.4μg/month)、ヘモグロビン(Hb)は8.70±1.1g/dlから10.0±1.2g/dlに上昇していた(p<0.001)。鉄剤の使用やRAの治療強化のなかった15例でも、Hbは9.1±0.8g/dlから10.1±1.2g/dlに上昇していた(p=0.028)。8例でCERAを中止でき、その後3例は再開したが、1例は再度中止することが可能であった。結論:RA患者においては、CKDが疑われる場合ではCrが低い場合でも、CERAを使用すべきと考えられた。(著者抄録)

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  • Association of coexisting anti-ribosomal P and anti-dsDNA antibodies with histology and renal prognosis in lupus nephritis patients

    Ayako Wakamatsu, Hiroe Sato, Yoshikatsu Kaneko, Takamasa Cho, Yumi Ito, Yoichi Kurosawa, Eriko Hasegawa, Daisuke Kobayashi, Takeshi Nakatsue, Takeshi Kuroda, Yoshiki Suzuki, Toshio Uchiumi, Ichiei Narita

    Lupus   096120332098390 - 096120332098390   2021年1月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：SAGE Publications  

    <sec><title>Objectives</title> Anti-ribosomal P protein autoantibodies (anti-P) specifically develop in patients with systemic lupus erythematosus. Associations of anti-P with lupus nephritis (LN) histological subclass and renal outcome remain inconclusive. We sought to determine the association of anti-P and anti-double-stranded DNA antibody (anti-dsDNA) with renal histology and prognosis in LN patients.

    </sec><sec><title>Methods</title> Thirty-four patients with LN, having undergone kidney biopsy, were included. The 2018 revised ISN/RPS classification system was used for pathophysiological evaluation. Chronic kidney disease (CKD) was defined as an estimated glomerular filtration rate &lt; 60 mL/min/1.73 m<sup>2</sup> for &gt; 3 months.

    </sec><sec><title>Results</title> Six patients (17.6%) were positive for anti-P and 26 (76.5%) for anti-dsDNA. Among the six patients with anti-P, one did not have anti-dsDNA, but did have anti-Sm antibody, and showed a histological subtype of class V. This patient maintained good renal function for over 14 years. The remaining five patients, who had both anti-P and anti-dsDNA, exhibited proliferative nephritis and were associated with prolonged hypocomplementemia, and the incidence of CKD did not differ from patients without anti-P.

    </sec><sec><title>Conclusion</title> Although this study included a small number of patients, the results indicated that histology class and renal prognosis associated with anti-P depend on the coexistence of anti-dsDNA. Further studies with a large number of patients are required to confirm this conclusion.

    </sec>

    DOI： 10.1177/0961203320983906

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    その他リンク： http://journals.sagepub.com/doi/full-xml/10.1177/0961203320983906

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MISC

  • ACTIVATED PARTIAL THROMBOPLASTIN TIME REFLECTS THE DISEASE ACTIVITY IN BOTH ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED SMALL VESSEL VASCULITIS AND TAKAYASU ARTERITIS

    Yoko Wada, Eriko Hasegawa, Ayako Wakamatsu, Yukiko Nozawa, Hiroe Sato, Takeshi Nakatsue, Takeshi Kuroda, Masaaki Nakano, Ichiei Narita

    RHEUMATOLOGY   56   127 - 127   2017年3月

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    記述言語：英語   掲載種別：研究発表ペーパー・要旨（国際会議）   出版者・発行元：OXFORD UNIV PRESS  

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