Updated on 2025/01/14

写真a

 
HASEGAWA Akito
 
Organization
University Medical and Dental Hospital Dermatology Assistant Professor
Title
Assistant Professor
External link

Degree

  • 博士(医学) ( 2020.9   新潟大学 )

Research Interests

  • 重症薬疹

Research Areas

  • Life Science / Dermatology  / 重症薬疹

Research History

  • Niigata University   Dermatology, University Medical and Dental Hospital   Assistant Professor

    2021.4

  • Niigata University   University Medical and Dental Hospital Dermatology   Specially Appointed Assistant Professor

    2020.10 - 2021.3

 

Papers

  • サラゾスルファピリジン誘発薬疹に関連するHLA-A*11:01、HLA-B*39:01およびHLA-B*56:03の同定

    福永 航也, 塚越 絵里, 中村 亮介, 松永 佳世子, 大関 健志, 渡辺 秀晃, 長谷川 瑛人, 濱 菜摘, 倉田 麻衣子, 水川 良子, 渡邉 裕子, 山口 由衣, 新原 寛之, 森田 栄伸, 浅田 秀夫, 阿部 理一郎, 斎藤 嘉朗, 莚田 泰誠

    MHC: Major Histocompatibility Complex   31 ( 2Suppl. )   82 - 82   2024.9

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    Language:Japanese   Publisher:(一社)日本組織適合性学会  

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  • リツキシマブにより消化管障害が改善した全身性強皮症の1例

    勝海 洸司, 濱 菜摘, 武居 いづみ, 木村 浄土, 土田 裕子, 安齋 理, 長谷川 瑛人, 阿部 理一郎, 小島 雄一

    日本皮膚科学会雑誌   134 ( 10 )   2589 - 2589   2024.9

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  • 新潟大学皮膚科における全身性強皮症に対するリツキシマブの治療効果および評価方法の検討

    加勢 夕季乃, 濱 菜摘, 木村 春奈, 安齋 理, 富井 光一, 長谷川 瑛人, 林 良太, 阿部 理一郎, 木村 慎二, 五十嵐 文枝, 田畑 智, 富山 勝博

    日本皮膚科学会雑誌   134 ( 7 )   1902 - 1902   2024.6

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  • 皮膚硬化型慢性GVHDに対してイブルチニブが有効であった1例

    佐藤 美紀, 濱 菜摘, 木村 春奈, 長谷川 瑛人, 阿部 理一郎, 諏訪部 達也, 柴崎 康彦, 増子 正義, 阿部 由紀子

    日本皮膚科学会雑誌   134 ( 7 )   1923 - 1923   2024.6

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  • 全身性強皮症にリツキシマブが奏効した7例

    加勢 夕季乃, 濱 菜摘, 木村 春奈, 安齋 理, 富井 光一, 長谷川 瑛人, 林 良太, 阿部 理一郎, 木村 慎二, 五十嵐 文枝, 田畑 智, 富山 勝博

    日本皮膚科学会雑誌   134 ( 7 )   1923 - 1923   2024.6

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  • アポトーシス・ネクロプトーシス・パイロトーシス抑制によるSJS/TENの新規医薬品の開発

    日下部 吉男, 露木 貴浩, 長谷川 瑛人, 濱 菜摘, 阿部 理一郎, 渡辺 秀晃

    日本皮膚科学会雑誌   134 ( 5 )   1485 - 1485   2024.5

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  • Differential Effects of HLA-B∗15:11 and HLA-A∗31:01 on Carbamazepine-Induced Cutaneous Adverse Reactions

    Koya Fukunaga, Eri Tsukagoshi, Maiko Kurata, Yoshiko Mizukawa, Hiroyuki Niihara, Eishin Morita, Yuko Watanabe, Yukie Yamaguchi, Hideaki Watanabe, Saeko Nakajima, Takashi Nomura, Kenji Kabashima, Mikiko Tohyama, Hiroaki Azukizawa, Hideo Asada, Akito Hasegawa, Natsumi Hama, Takeshi Ozeki, Yoichi Mashimo, Akihiro Sekine, Kayoko Matsunaga, Yoichi Tanaka, Ryosuke Nakamura, Riichiro Abe, Taisei Mushiroda, Yoshiro Saito

    Journal of Investigative Dermatology   144 ( 4 )   908 - 911.e7   2024.4

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.jid.2023.09.282

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  • Deep dermatophytosis caused by Trichophyton rubrum in an elderly patient with CARD9 deficiency: A case report and literature review. International journal

    Osamu Ansai, Ryota Hayashi, Anna Nakamura, Jin Sasaki, Akito Hasegawa, Tokiko Deguchi, Akihiko Yuki, Naoki Oike, Takashi Ariizumi, Masahiro Abe, Yoshitsugu Miyazaki, Tatsuya Takenouchi, Hiroyuki Kawashima, Riichiro Abe

    The Journal of dermatology   51 ( 2 )   294 - 300   2024.2

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    Deep dermatophytosis is an invasive and sometimes life-threatening fungal infection mainly reported in immunocompromised patients. However, a caspase recruitment domain-containing protein 9 (CARD9) deficiency has recently been reported to cause deep dermatophytosis. Herein, we report the first Japanese case of deep dermatophytosis associated with CARD9 deficiency. An 80-year-old Japanese man with tinea corporis presented with subcutaneous nodules on his left sole. Histopathological findings revealed marked epithelioid cell granulomas with filamentous fungal structures in the deep dermis and subcutis, and the patient was diagnosed with deep dermatophytosis. Despite antifungal therapy, the subcutaneous nodule on his left sole gradually enlarged, his left calcaneal bone was invaded, and the patient finally underwent amputation of his left leg. Genetic analysis revealed a homozygous CARD9 c.586 A > G (p. Lys196Glu) variant, suggesting a CARD9 deficiency. Here, we discuss the clinical features of CARD9 deficiency-associated deep dermatophytosis with a case report and review of the literature.

    DOI: 10.1111/1346-8138.16995

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  • 難治性天疱瘡にリツキシマブを投与した3症例

    島田 奏, 長谷川 瑛人, 勝海 洸司, 木村 春奈, 武居 慎吾, 河合 亨, 萩原 里沙, 安齋 理, 富井 光一, 林 良太, 濱 菜摘, 阿部 理一郎, 梅森 幸恵

    日本皮膚科学会雑誌   133 ( 8 )   1870 - 1870   2023.7

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  • Mycobacterium chelonaeによる皮膚非結核性抗酸菌症の2例

    大橋 凌也, 長谷川 瑛人, 木村 春奈, 安齋 理, 濱 菜摘, 阿部 理一郎, 小林 大介, 尾方 英至, 松山 麻子

    日本皮膚科学会雑誌   133 ( 8 )   1871 - 1871   2023.7

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  • Unilateral nevoid telangiectasia 5例の臨床的検討

    佐藤 碩昭, 濱 菜摘, 安齋 理, 長谷川 瑛人, 土田 裕子, 林 良太, 藤本 篤, 藤原 浩, 阿部 理一郎, 池滝 知, 高橋 美千代, 野本 真由美

    日本皮膚科学会雑誌   133 ( 8 )   1868 - 1868   2023.7

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  • Grover病に対する紫外線療法後に紅斑性天疱瘡を合併した1例

    佐藤 碩昭, 安齋 理, 鈴木 紗也佳, 寺尾 香菜, 内田 梢太, 勝海 洸司, 佐藤 亜美, 木村 浄土, 長谷川 瑛人, 結城 明彦, 濱 菜摘, 阿部 理一郎, 結城 大介

    日本皮膚科学会雑誌   133 ( 8 )   1867 - 1867   2023.7

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  • Mycobacterium chelonaeによる皮膚非結核性抗酸菌症の2例

    大橋 凌也, 長谷川 瑛人, 木村 春奈, 安齋 理, 濱 菜摘, 阿部 理一郎, 小林 大介, 尾方 英至, 松山 麻子

    日本皮膚科学会雑誌   133 ( 8 )   1871 - 1871   2023.7

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  • 皮膚硬化型慢性GVHDに対してイブルチニブが有効であった1例

    佐藤 美紀, 濱 菜摘, 木村 春奈, 長谷川 瑛人, 阿部 理一郎, 阿部 由紀子, 諏訪部 達也, 柴崎 康彦, 増子 正義

    日本皮膚科学会雑誌   133 ( 5 )   1420 - 1420   2023.5

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  • Interleukin-18 as a severity marker and novel potential therapeutic target for epidermolytic ichthyosis. International journal

    Osamu Ansai, Toshinari Miyauchi, Ryota Hayashi, Tatsuya Katsumi, Tomoki Nishiguchi, Akito Hasegawa, Satoru Shinkuma, Ken Natsuga, Toshifumi Nomura, Yutaka Shimomura, Riichiro Abe

    Clinical and experimental dermatology   48 ( 3 )   199 - 210   2023.3

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    BACKGROUND: Epidermolytic ichthyosis (EI) is a major form of nonsyndromic inherited ichthyosis, characterized by erythroderma, marked hyperkeratosis and scale, bulla and erosion at birth, associated with KRT1/KRT10 mutations. The cytokine and chemokine profiles in EI are poorly understood, and specific treatment options have not been established. AIM: To explore novel biomarkers and therapeutic targets in patients with EI. METHODS: We analysed cytokine levels in serum and skin samples from 10 patients with inherited ichthyosis, including seven patients with EI. Wild-type and mutant KRT1 constructs were established and transfected into HaCaT cells, an immortalized keratinocyte cell line, for in vitro immunoblotting and immunocytochemistry analyses. RESULTS: Multiplex cytokine/chemokine analysis revealed that 10 cytokines/chemokines [interleukin (IL)-1β, IL-4, IL-17A, IL-16, IL-18, IL-1 receptor-α, macrophage colony-stimulating factor, interferon-α2, basic fibroblast growth factor and monocyte chemotactic protein-3] were significantly increased in patients with EI. Furthermore, IL-18 levels were significantly higher in patients with EI [n = 7; 2714.1 (1438.0) pg mL-1] than in healthy controls [n = 11; 218.4 (28.4) pg mL-1, P < 0.01]. Immunohistochemical analyses showed that IL-18 expression was elevated in skin samples from patients with EI. Serum IL-18 levels correlated with the severity of ichthyosis, as measured by the Ichthyosis Scoring System. Immunoblotting analysis revealed that mature IL-18 levels were increased in the supernatant of mutant KRT1 expressing HaCaT cells. Additionally, these cells showed NLRP3 aggregation in the cytoplasm and ASC clustered around mutant keratin aggregations. These findings suggest that mutant keratin might promote the activation of the NLRP3 inflammasome and its downstream caspase-1-mediated IL-18 release in keratinocytes from patients with EI. CONCLUSIONS: Our results suggest that serum IL-18 is a severity marker released from the skin of patients with EI. Blockade of IL-18 may be a useful novel therapeutic option for patients with EI.

    DOI: 10.1093/ced/llac069

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  • Histiocytoid Sweet syndrome as a rare skin manifestation of relapsing polychondritis. International journal

    Kana Terao-Hirayama, Akito Hasegawa, Shingo Takei, Tatsuya Katsumi, Akihiko Yuki, Natsumi Hama, Eriko Hasegawa, Hiroe Sato, Daisuke Kobayashi, Riichiro Abe

    The Journal of dermatology   2023.2

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  • エタネルセプトが著効した小児中毒性表皮壊死症(TEN)の1例

    武居 いづみ, 長谷川 瑛人, 荻根沢 真帆子, 土田 裕子, 酒井 あかり, 濱 菜摘, 阿部 理一郎, 金子 昌弘, 金子 詩子, 晝間 優隆, 松井 亨, 本田 博之

    西日本皮膚科   84 ( 6 )   575 - 575   2022.12

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  • 本邦で初めて中毒性表皮壊死症にエタネルセプトを投与した1例

    荻根沢 真帆子, 濱 菜摘, 武居 いづみ, 土田 裕子, 酒井 あかり, 長谷川 瑛人, 阿部 理一郎, 金子 昌弘, 金子 詩子, 松井 亨, 本田 博之

    日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集   52回   193 - 193   2022.12

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  • リツキシマブにより消化管障害が改善した全身性強皮症の1例

    勝海 洸司, 濱 菜摘, 武居 いづみ, 木村 浄土, 土田 裕子, 安齋 理, 長谷川 瑛人, 阿部 理一郎, 小島 雄一

    日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集   52回   201 - 201   2022.12

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  • Sweet病様の皮疹が先行した再発性多発軟骨炎の1例

    寺尾 香菜, 長谷川 瑛人, 内田 梢太, 島田 奏, 筒井 由夏, 武居 慎吾, 横山 彩乃, 勝見 達也, 佐藤 亜美, 加畑 雄大, 結城 明彦, 藤本 篤, 濱 菜摘, 阿部 理一郎, 長谷川 絵理子, 佐藤 弘恵, 小林 大介

    日本皮膚科学会雑誌   132 ( 6 )   1490 - 1490   2022.5

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  • エタネルセプト(ETN)が奏効した小児中毒性表皮壊死症(TEN)の1例 Reviewed

    武居 いづみ, 長谷川 瑛人, 鈴木 紗也佳, 荻根沢 真帆子, 木村 浄土, 安齋 理, 土田 裕子, 酒井 あかり, 濱 菜摘, 阿部 理一郎, 金子 昌弘, 金子 詩子, 晝間 優隆, 松井 亨, 本田 博之, 会沢 敦子

    日本皮膚科学会雑誌   132 ( 6 )   1496 - 1496   2022.5

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  • エタネルセプト(ETN)が奏効した小児中毒性表皮壊死症(TEN)の1例

    武居 いづみ, 長谷川 瑛人, 鈴木 紗也佳, 荻根沢 真帆子, 木村 浄土, 安齋 理, 土田 裕子, 酒井 あかり, 濱 菜摘, 阿部 理一郎, 金子 昌弘, 金子 詩子, 晝間 優隆, 松井 亨, 本田 博之, 会沢 敦子

    日本皮膚科学会雑誌   132 ( 6 )   1496 - 1496   2022.5

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  • 発症早期に薬剤性過敏症症候群様の症状を呈した中毒性表皮壊死症の1例

    勝海 洸司, 出口 登希子, 島田 奏, 木村 春奈, 佐藤 亜美, 荻根沢 真帆子, 安齋 理, 鈴木 丈雄, 長谷川 瑛人, 酒井 あかり, 濱 菜摘, 阿部 理一郎, 原 寛

    日本皮膚科学会雑誌   132 ( 2 )   357 - 357   2022.2

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  • Pustular Skin Lesions in an Adult Female Patient with X-linked Dominant Chondrodysplasia Punctata with a Novel Emopamil Binding Protein Mutation: A Rare Skin Manifestation. Reviewed International journal

    Akito Hasegawa, Satoru Shinkuma, Ryota Hayashi, Yutaka Shimomura, Riichiro Abe

    Acta dermato-venereologica   101 ( 9 )   adv00547   2021.9

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    DOI: 10.2340/00015555-3916

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  • Congenital leukonychia caused by a mutation in GJB2. International journal

    Rei Yokoyama, Ryota Hayashi, Osamu Ansai, Akito Hasegawa, Satoru Shinkuma, Riichiro Abe

    European journal of dermatology : EJD   31 ( 4 )   560 - 562   2021.8

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    DOI: 10.1684/ejd.2021.4089

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  • Stevens-Johnson症候群(SJS)/中毒性表皮壊死症(TEN)の新規病態メカニズムと新規早期診断マーカーの有用性

    木下 真直, 小川 陽一, 島田 眞路, 川村 龍吉, 濱 菜摘, 長谷川 瑛人, 阿部 理一郎, 氏家 韻欣, 藤田 靖幸, 中島 沙恵子, 野村 尚史, 高橋 勇人, 水川 良子

    日本皮膚科学会雑誌   131 ( 8 )   1874 - 1874   2021.7

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  • スティーヴンス・ジョンソン症候群と鑑別を要した粘膜病変を伴う固定薬疹の5例

    石渡 彩乃, 加畑 雄大, 鈴木 丈雄, 長谷川 瑛人, 土田 裕子, 出口 登希子, 林 良太, 重原 庸哉, 阿部 理一郎, 会沢 敦子, 三井田 博

    日本皮膚科学会雑誌   131 ( 8 )   1879 - 1880   2021.7

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  • Neutrophils initiate and exacerbate Stevens-Johnson syndrome and toxic epidermal necrolysis. International journal

    Manao Kinoshita, Youichi Ogawa, Natsumi Hama, Inkin Ujiie, Akito Hasegawa, Saeko Nakajima, Takashi Nomura, Jun Adachi, Takuya Sato, Schuichi Koizumi, Shinji Shimada, Yasuyuki Fujita, Hayato Takahashi, Yoshiko Mizukawa, Takeshi Tomonaga, Keisuke Nagao, Riichiro Abe, Tatsuyoshi Kawamura

    Science translational medicine   13 ( 600 )   2021.6

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    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening mucocutaneous adverse drug reactions characterized by massive epidermal detachment. Cytotoxic T cells and associated effector molecules are known to drive SJS/TEN pathophysiology, but the contribution of innate immune responses is not well understood. We describe a mechanism by which neutrophils triggered inflammation during early phases of SJS/TEN. Skin-infiltrating CD8+ T cells produced lipocalin-2 in a drug-specific manner, which triggered the formation of neutrophil extracellular traps (NETs) in early lesional skin. Neutrophils undergoing NETosis released LL-37, an antimicrobial peptide, which induced formyl peptide receptor 1 (FPR1) expression by keratinocytes. FPR1 expression caused keratinocytes to be vulnerable to necroptosis that caused further release of LL-37 by necroptotic keratinocytes and induced FPR1 expression on surrounding keratinocytes, which likely amplified the necroptotic response. The NETs-necroptosis axis was not observed in less severe cutaneous adverse drug reactions, autoimmune diseases, or neutrophil-associated disorders, suggesting that this was a process specific to SJS/TEN. Initiation and progression of SJS/TEN keratinocyte necroptosis appear to involve a cascade of events mediated by innate and adaptive immune responses, and understanding these responses may contribute to the identification of diagnostic markers or therapeutic targets for these adverse drug reactions.

    DOI: 10.1126/scitranslmed.aax2398

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  • The role of IL-8 in skin lesions of a patient with erythema elevatum diutinum. International journal

    H Kimura, R Hayashi, Y Tsuchida, A Hasegawa, Y Kabata, M Tamura, R Abe

    Journal of the European Academy of Dermatology and Venereology : JEADV   35 ( 6 )   e396-e399   2021.6

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    DOI: 10.1111/jdv.17179

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  • Alopecia areata and psoriasis vulgaris associated with Turner syndrome. International journal

    Rei Yokoyama, Ryota Hayashi, Osamu Ansai, Akito Hasegawa, Satoru Shinkuma, Yutaka Shimomura, Riichiro Abe

    The Australasian journal of dermatology   62 ( 3 )   e453-e455   2021.5

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    DOI: 10.1111/ajd.13597

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  • Pregnancy‐triggered atypical extrapalmoplantar erythematous hyperkeratotic lesions in palmoplantar keratoderma with mitochondrial mutations Reviewed

    O. Ansai, R. Hayashi, A. Nakamura, A. Arimatsu‐Sato, A. Hasegawa, A. Yuki, A. Fujimoto, N. Hama, S. Shinkuma, Y. Shimomura, R. Abe

    Journal of the European Academy of Dermatology and Venereology   35 ( 4 )   2021.4

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1111/jdv.17020

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jdv.17020

  • Characteristic pathological features of keratinocyte death in a case of Stevens-Johnson syndrome manifested by an immune checkpoint inhibitor. International journal

    H Kimura, A Hasegawa, I Takei, T Kawai, Y Tsuchida, Y Abe, R Hayashi, N Hama, R Abe

    Journal of the European Academy of Dermatology and Venereology : JEADV   35 ( 2 )   e142-e145   2021.2

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    DOI: 10.1111/jdv.16872

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  • Only plantar lesion of punctate palmoplantar keratoderma with a novel missense mutation in the AAGAB gene: Two Japanese familial case reports and review of reported mutations International journal

    Hasegawa, Akito, Hayashi, Ryota, Shimomura, Yutaka, Hirashima, Masanori, Abe, Riichiro

    The Journal of Dermatology   48 ( 12 )   1926 - 1930   2021

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    Punctate palmoplantar keratoderma type 1 (PPPK1) is a rare autosomal dominant disorder characterized by hyperkeratotic papules on the palms and soles. In 2012, heterozygous loss-of-function mutations in the AAGAB gene were identified as the cause of this disorder. To date, 51 AAGAB mutations have been reported in families with PPPK1, but clear genotype-phenotype correlations have not been established yet. In this report, we identified four Japanese patients with PPPK1 from two families with an identical novel heterozygous AAGAB mutation. All patients showed hyperkeratotic papules only on the soles. Direct sequencing analysis of the AAGAB gene using peripheral blood-derived genomic DNA samples revealed that all of the patients carried a heterozygous 1-bp substitution (c.844G>A, p.Glu282Lys) in exon 9, leading to a missense change. Since all patients with the same missense mutation showed a mild phenotype limited to the soles, there is thought to be a genotype-phenotype correlation regarding this mutation. The c.844G>A mutation is a known single-nucleotide polymorphism with a minor allele frequency of 0.000012. Because of its mild symptoms, individuals with this mutation can be misdiagnosed with clavus or verruca vulgaris; this suggests that there may be a high incidence of mild symptoms of skin lesions found only on the soles in patients with PPPK1. Therefore, it is necessary to consider this disease when keratotic papules are found on the soles.

    DOI: 10.1111/1346-8138.16162

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  • [PATHOGENESIS OF SEVERE CUTANEOUS ADVERSE REACTIONS: NECROPTOSIS IN STEVENS-JOHNSON SYNDROME/TOXIC EPIDERMAL NECROLYSIS].

    Yuki Saito, Akito Hasegawa, Riichiro Abe

    Arerugi = [Allergy]   70 ( 4 )   282 - 288   2021

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    DOI: 10.15036/arerugi.70.282

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  • 薬剤性発敏症症候群(DIHS)から中毒性表皮壊死症(TEN)へ進展しニューモシスチス肺炎を発症した1例

    武居 慎吾, 加畑 雄大, 勝海 洸司, 木村 春奈, 中村 杏奈, 岩井 由樹, 鈴木 丈雄, 長谷川 瑛人, 濱 菜摘, 阿部 理一郎, 鈴木 隆晴, 河本 啓介, 和泉 純子

    日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集   50回   214 - 214   2020.12

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  • Recent advances in managing and understanding Stevens-Johnson syndrome and toxic epidermal necrolysis [version 1; peer review: 2 approved] International journal

    Akito Hasegawa, Riichiro Abe

    F1000Research   9   2020.6

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    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases characterized by detachment of the epidermis and mucous membrane. SJS/TEN are considered to be on the same spectrum of diseases with different severities. They are classified by the percentage of skin detachment area. SJS/TEN can also cause several complications in the liver, kidneys, and respiratory tract. The pathogenesis of SJS/TEN is still unclear. Although it is difficult to diagnose early stage SJS/TEN, biomarkers for diagnosis or severity prediction have not been well established. Furthermore, optimal therapeutic options for SJS/TEN are still controversial. Several drugs, such as carbamazepine and allopurinol, are reported to have a strong relationship with a specific human leukocyte antigen (HLA) type. This relationship differs between different ethnicities. Recently, the usefulness of HLA screening before administering specific drugs to decrease the incidence of SJS/TEN has been investigated. Skin detachment in SJS/TEN skin lesions is caused by extensive epidermal cell death, which has been considered to be apoptosis via the Fas-FasL pathway or perforin/granzyme pathway. We reported that necroptosis, i.e. programmed necrosis, also contributes to epidermal cell death. Annexin A1, released from monocytes, and its interaction with the formyl peptide receptor 1 induce necroptosis. Several diagnostic or prognostic biomarkers for SJS/TEN have been reported, such as CCL-27, IL-15, galectin-7, and RIP3. Supportive care is recommended for the treatment of SJS/TEN. However, optimal therapeutic options such as systemic corticosteroids, intravenous immunoglobulin, cyclosporine, and TNF-α antagonists are still controversial. Recently, the beneficial effects of cyclosporine and TNF-α antagonists have been explored. In this review, we discuss recent advances in the pathophysiology and management of SJS/TEN.

    DOI: 10.12688/f1000research.24748.1

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  • Localized bullous pemphigoid recurring at different sites: two case reports. International journal

    Akito Hasegawa

    European journal of dermatology : EJD   2020.2

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    BACKGROUND:Localized bullous pemphigoid is a relatively rare variant of bullous pemphigoid. Lesions develop only in localized sites including the legs or palms and soles and occasionally appear in trauma-affected body parts. In some cases, the skin lesions spread to the entire body, while in others, they remain localized and improve spontaneously or with treatment using topical corticosteroids. Rarely, the lesions recur at sites different from those of the original lesions, after the initial lesions have completely healed. OBJECTIVES:To investigate the clinical course of patients with localized bullous pemphigoid. MATERIALS AND METHODS:Two cases of localized bullous pemphigoid that recurred at sites distant from those of the initial lesions were reported. RESULTS:Case 1 involved a 62-year-old woman with mucous membrane pemphigoid. One year after the improvement of mucosal symptoms, new lesions appeared in the periumbilical area. The lesions resolved after topical corticosteroid treatment. This case is the first report of localized bullous pemphigoid occurring after an improvement of mucous membrane pemphigoid. Case 2 involved an 81-year-old man who bruised his right lower leg and developed erythematous plaques and tense bullae. The patient was diagnosed with localized bullous pemphigoid and was treated with topical corticosteroid. However, six months later, new lesions appeared on the palms and soles. The patient responded well to oral prednisolone. CONCLUSIONS:Since localized bullous pemphigoid may have a variable clinical course, clinicians should observe affected patients carefully over a long period of time.

    DOI: 10.1684/ejd.2019.3672

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  • RIP3 as a diagnostic and severity marker for Stevens-Johnson syndrome and toxic epidermal necrolysis. International journal

    Akito Hasegawa

    The journal of allergy and clinical immunology. In practice   8 ( 5 )   1768 - 1771   2020.1

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    DOI: 10.1016/j.jaip.2020.01.006

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  • 初発部位とは異なる部位に皮疹が生じた限局性水疱性類天疱瘡(LBP)の2例

    長谷川 瑛人, 新熊 悟, 勝見 達也, 阿部 理一郎, 伊藤 薫, 笠原 直美, 池滝 勝史, 氏家 英之

    日本皮膚科学会雑誌   129 ( 4 )   551 - 551   2019.4

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  • Reply.

    Akito Hasegawa

    The Journal of Allergy and Clinical Immunology   2019.3

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    DOI: 10.1016/j.jaci.2019.02.012

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  • Blockade of TNF receptor superfamily 1 (TNFR1)-dependent and TNFR1-independent cell death is crucial for normal epidermal differentiation. Reviewed International journal

    Xuehua Piao, Ryosuke Miura, Sanae Miyake, Sachiko Komazawa-Sakon, Masato Koike, Ryodai Shindo, Junji Takeda, Akito Hasegawa, Riichiro Abe, Chiharu Nishiyama, Tetsuo Mikami, Hideo Yagita, Yasuo Uchiyama, Hiroyasu Nakano

    The Journal of allergy and clinical immunology   143 ( 1 )   213 - 228   2019.1

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    BACKGROUND: A delicate balance between cell death and keratinocyte proliferation is crucial for normal skin development. Previous studies have reported that cellular FLICE (FADD-like ICE)-inhibitory protein plays a crucial role in prevention of keratinocytes from TNF-α-dependent apoptosis and blocking of dermatitis. However, a role for cellular FLICE-inhibitory protein in TNF-α-independent cell death remains unclear. OBJECTIVE: We investigated contribution of TNF-α-dependent and TNF-α-independent signals to the development of dermatitis in epidermis-specific Cflar-deficient (CflarE-KO) mice. METHODS: We examined the histology and expression of epidermal differentiation markers and inflammatory cytokines in the skin of CflarE-KO;Tnfrsf1a+/- and CflarE-KO;Tnfrsf1a-/- mice. Mice were treated with neutralizing antibodies against Fas ligand and TNF-related apoptosis-inducing ligand to block TNF-α-independent cell death of CflarE-KO;Tnfrsf1a-/- mice. RESULTS: CflarE-KO;Tnfrsf1a-/- mice were born but experienced severe dermatitis and succumbed soon after birth. CflarE-KO;Tnfrsf1a+/- mice exhibited embryonic lethality caused by massive keratinocyte apoptosis. Although keratinocytes from CflarE-KO;Tnfrsf1a-/- mice still died of apoptosis, neutralizing antibodies against Fas ligand and TNF-related apoptosis-inducing ligand substantially prolonged survival of CflarE-KO;Tnfrsf1a-/- mice. Expression of inflammatory cytokines, such as Il6 and Il17a was increased; conversely, expression of epidermal differentiation markers was severely downregulated in the skin of CflarE-KO;Tnfrsf1a-/- mice. Treatment of primary keratinocytes with IL-6 and, to a lesser extent, IL-17A suppressed expression of epidermal differentiation markers. CONCLUSION: TNF receptor superfamily 1 (TNFR1)-dependent or TNFR1-independent apoptosis of keratinocytes promotes inflammatory cytokine production, which subsequently blocks epidermal differentiation. Thus blockade of both TNFR1-dependent and TNFR1-independent cell death might be an alternative strategy to treat skin diseases when treatment with anti-TNF-α antibody alone is not sufficient.

    DOI: 10.1016/j.jaci.2018.02.043

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  • Galectin-7 as a potential biomarker of Stevens-Johnson syndrome/toxic epidermal necrolysis: identification by targeted proteomics using causative drug-exposed peripheral blood cells Reviewed

    Hama, Natsumi, Nishimura, Keiko, Hasegawa, Akito, Yuki, Akihiko, Kume, Hideaki, Adachi, Jun, Kinoshita, Manao, Ogawa, Youichi, Nakajima, Saeko, Nomura, Takashi, others

    The Journal of Allergy and Clinical Immunology: In Practice   7 ( 8 )   2894 - 2897   2019

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    DOI: 10.1016/j.jaip.2019.05.002

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  • Severe thrombocytopenia induced by intravenous immunoglobulin therapy in a patient with bullous pemphigoid Reviewed

    Yokoyama Rei, Hama Natsumi, Kimura Kiyoto, Hasegawa Akito, Kibune Natsuko, Kariya Naoyuki, Yuki Naokata, Abe Riichiro

    DERMATOLOGICA SINICA   36 ( 3 )   163 - 164   2018.9

  • PR3-ANCA: a potential biomarker of disease activity for propylthiouracil-induced ANCA-associated vasculitis.

    Akito Hasegawa

    European journal of dermatology : EJD   2018.8

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    DOI: 10.1684/ejd.2018.3314

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  • Potential role of extracellular vesicle-mediated antigen presentation in Helicobacter pylori hypersensitivity during eradication therapy. Reviewed International journal

    Takamasa Ito, Takashi Shiromizu, Shunsuke Ohnishi, Shotaro Suzuki, Katsuhiro Mabe, Akito Hasegawa, Hideyuki Ujiie, Yasuyuki Fujita, Yuichi Sato, Shuji Terai, Mototsugu Kato, Masahiro Asaka, Takeshi Tomonaga, Hiroshi Shimizu, Riichiro Abe

    The Journal of allergy and clinical immunology   142 ( 2 )   672 - 676   2018.8

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  • Panniculitis as the initial manifestation of dermatomyositis with anti-MDA5 antibody.

    Akito Hasegawa

    Clinical and experimental dermatology   2017.5

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    DOI: 10.1111/ced.13128

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  • 急性汎発性発疹性膿疱症を合併したWerner症候群の1例

    河合 亨, 林 良太, 木村 浄土, 横山 令, 長谷川 瑛人, 貴舩 夏子, 藤本 篤, 濱 菜摘, 下村 裕, 阿部 理一郎

    日本皮膚科学会雑誌   127 ( 5 )   1173 - 1173   2017.5

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  • Beneficial effect of hydroxychloroquine on cutaneous vasculitis in a Japanese patient with systemic lupus erythematosus. Reviewed International journal

    Natsuko Kibune, Yutaka Shimomura, Akito Hasegawa, Takako Saeki, Yukie Umemori, Riichiro Abe

    The Journal of dermatology   44 ( 4 )   e52-e53   2017.4

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MISC

  • Two cases of motor nerve palsy associated with disseminated herpes zoster

    SUZUKI Sayaka, ANSAI Osamu, TAKEI Izumi, KIMURA Kiyoto, HASEGAWA Akito, TSUCHIDA Yuko, ABE Riichiro, NAKAMURA Kosei, HONGO Shoko, TSUBOGUCHI Shintaro, SAJI Koji, MURATA Masaki

    日本皮膚科学会雑誌   133 ( 2 )   2023

  • Sweet病様の皮疹が先行した再発性多発軟骨炎の1例

    寺尾 香菜, 長谷川 瑛人, 内田 梢太, 島田 奏, 筒井 由夏, 武居 慎吾, 横山 彩乃, 勝見 達也, 佐藤 亜美, 加畑 雄大, 結城 明彦, 藤本 篤, 濱 菜摘, 阿部 理一郎, 長谷川 絵理子, 佐藤 弘恵, 小林 大介

    日本皮膚科学会雑誌   132 ( 6 )   1490 - 1490   2022.5

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  • 薬剤性過敏症症候群(DIHS)様症状で発症した血管免疫芽球性T細胞リンパ腫(AITL)の1例

    内田 梢太, 長谷川 瑛人, 寺尾 香菜, 武居 慎吾, 佐藤 亜美, 阿部 理一郎, 吉澤 優太, 諏訪部 達也, 瀧澤 淳, 笠井 昭男

    日本皮膚科学会雑誌   132 ( 6 )   1490 - 1490   2022.5

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    J-GLOBAL

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  • ヨード造影剤で増悪したDuhring疱疹状皮膚炎の1例

    筒井 由夏, 長谷川 瑛人, 内田 梢太, 平山 香菜, 武居 慎吾, 石渡 彩乃, 佐藤 亜美, 加畑 雄大, 林 良太, 藤川 大基, 阿部 理一郎, 坂牧 僚, 上村 顕也, 冨樫 きょう子

    日本皮膚科学会雑誌   131 ( 8 )   1883 - 1883   2021.7

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  • 当初薬剤性過敏症症候群と診断された血管免疫芽球性T細胞リンパ腫の1例

    内田 梢太, 長谷川 瑛人, 平山 香菜, 武居 慎吾, 佐藤 亜美, 吉澤 優太, 諏訪部 達也, 瀧澤 淳, 笠井 昭男, 阿部 理一郎

    日本皮膚科学会雑誌   131 ( 5 )   1364 - 1364   2021.5

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  • 薬疹 原因薬剤添加末梢血単核球培養上清を用いたプロテオーム解析によるスティーブンス・ジョンソン症候群/中毒性表皮壊死症のバイオマーカーの同定

    濱 菜摘, 西村 慶子, 長谷川 瑛人, 結城 明彦, 久米 秀明, 足立 淳, 木下 真直, 小川 陽一, 中島 沙恵子, 野村 尚史, 渡辺 秀晃, 水川 良子, 朝長 毅, 清水 宏, 阿部 理一郎

    日本皮膚免疫アレルギー学会雑誌   3 ( 1 )   193 - 193   2019.11

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  • 薬疹 原因薬剤添加末梢血単核球培養上清を用いたプロテオーム解析によるスティーブンス・ジョンソン症候群/中毒性表皮壊死症のバイオマーカーの同定

    濱 菜摘, 西村 慶子, 長谷川 瑛人, 結城 明彦, 久米 秀明, 足立 淳, 木下 真直, 小川 陽一, 中島 沙恵子, 野村 尚史, 渡辺 秀晃, 水川 良子, 朝長 毅, 清水 宏, 阿部 理一郎

    日本皮膚免疫アレルギー学会雑誌   3 ( 1 )   193 - 193   2019.11

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  • 口腔内病変を伴った関節症性乾癬の1例

    岩井 由樹, 藤本 篤, 河合 亨, 長谷川 瑛人, 貴舩 夏子, 濱 菜摘, 苅谷 直之, 阿部 理一郎, 伊藤 加代子, 窪田 和, 近藤 直樹

    日本皮膚科学会雑誌   127 ( 4 )   632 - 632   2017.4

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  • プロピルチオウラシル(PTU)によるANCA陽性血管炎の1例

    長谷川 瑛人, 結城 大介, 林 良太, 会沢 敦子, 藤本 篤, 伊藤 崇子, 田村 正和

    日本皮膚科学会雑誌   125 ( 3 )   461 - 461   2015.3

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  • アモキシシリン水和物(AMPC)投与後に皮疹が生じた伝染性単核球症の1例

    鈴木 丈雄, 長谷川 瑛人, 有波 浩, 松尾 淑江, 松山 麻子, 瀧澤 淳

    日本皮膚科学会雑誌   125 ( 3 )   459 - 460   2015.3

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Research Projects

  • 重症薬疹の病態解明と新規バイオマーカーの開発

    Grant number:21K16205

    2021.4 - 2023.3

    System name:科学研究費助成事業 若手研究

    Research category:若手研究

    Awarding organization:日本学術振興会

    長谷川 瑛人

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    スティーブンス・ジョンソン症候群(SJS)や中毒性表皮壊死症(TEN)は、広範囲のびらん
    を特徴とする、重篤な薬疹である。SJS/TENでは、表皮細胞がアポトーシスやネクロプトーシスというタイプの細胞死を起こす。このアポトーシス経路とネクロプトーシス経路は、インフラマゾーム経路と互いに関与し合う。インフラマゾーム経路は、caspase 1が活性化することで、IL-1βやIL-18を細胞外へ放出されることで周囲に炎症を起こす。またcaspase 1の活性化によりgasdermin Dが切断され活性化し、パイロトーシスという細胞死を引き起こす。
    本研究は、SJS/TENの病態にインフラマゾーム経路が関与するかを解明する。SJS/TENの
    病態を新たに解明することで、早期診断、重症度予測のための、新規バイオマーカーの開発
    を目指す。そのために①細胞モデルを用いた解析、②multiplex assayを用いた網羅的解析を計画している。
    本年度はまず、SJS/TENの病変部の表皮細胞で実際にパイロトーシスが起きているかどうか解析した。病変部の表皮細胞で、活性型gasdermin Dが検出されたことから、SJS/TENの病変部でパイロトーシスが起きていることを確認できた。次に、インフラマゾーム経路がアポトーシス、ネクロプトーシスの経路と相互に作用しあって起きているのか、または独立して起きているかなどを解析するために、SJS/TENのモデル細胞の作製を行った。不死化表皮細胞であるHaCaT細胞にP2X7受容体刺激とFPR1刺激を加えることで細胞死を誘導できるモデル細胞の作製に成功した。今後はこのモデル細胞を用いてインフラマゾーム経路の活性化やその他の経路との関連の解析を行う予定である。

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