Updated on 2022/06/26


Brain Research Institute Assistant Professor
Assistant Professor
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  • 博士(医学) ( 2021.3 )

  • 修士(医科学) ( 2017.3 )

Research History

  • Niigata University   Brain Research Institute   Assistant Professor




  • Neonatal social isolation increases the proportion of the immature spines in the layer 2/3 pyramidal neurons of the somatosensory cortex Reviewed

    Risa Iguchi, Shinji Tanaka, Shigeo Okabe

    154   27 - 34   2020.5

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    Authorship:Lead author   Language:English  


  • Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice Reviewed International journal

    Te-Chen Tzeng, Yuto Hasegawa, Risa Iguchi, Amy Cheung, Daniel R. Caffrey, Elizabeth Jeanne Thatcher, Wenjie Mao, Gail Germain, Nelsy DePaula Tamburro, Shigeo Okabe, Michael T. Heneka, Eicke Latz, Kensuke Futai, Douglas T. Golenbock

    Proceedings of the National Academy of Sciences of the United States of America   115 ( 36 )   9002 - 9007   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    Alzheimer's disease (AD) is characterized by the progressive destruction and dysfunction of central neurons. AD patients commonly have unprovoked seizures compared with age-matched controls. Amyloid peptide-related inflammation is thought to be an important aspect of AD pathogenesis. We previously reported that NLRP3 inflammasome KO mice, when bred into APPswe/PS1ΔE9 (APP/PS1) mice, are completely protected from amyloid-induced AD-like disease, presumably because they cannot produce mature IL1β or IL18. To test the role of IL18, we bred IL18KO mice with APP/PS1 mice. Surprisingly, IL18KO/APP/PS1 mice developed a lethal seizure disorder that was completely reversed by the anticonvulsant levetiracetam. IL18-deficient AD mice showed a lower threshold in chemically induced seizures and a selective increase in gene expression related to increased neuronal activity. IL18-deficient AD mice exhibited increased excitatory synaptic proteins, spine density, and basal excitatory synaptic transmission that contributed to seizure activity. This study identifies a role for IL18 in suppressing aberrant neuronal transmission in AD.

    DOI: 10.1073/pnas.1801802115



  • 中枢神経系シナプス形成の多様性の分子基盤

    井口理沙, 岩崎広英, 岡部繫男

    89 ( 1 )   77 - 80   2017

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Teaching Experience

  • 学問の扉 知と方法の最前線

    Institution name:新潟大学