2022/05/26 更新

写真a

イグチ リサ
井口 理沙
IGUCHI Risa
所属
脳研究所 助教
職名
助教
外部リンク

学位

  • 博士(医学) ( 2021年3月 )

  • 修士(医科学) ( 2017年3月 )

経歴

  • 新潟大学   脳研究所   助教

    2021年4月 - 現在

 

論文

  • Neonatal social isolation increases the proportion of the immature spines in the layer 2/3 pyramidal neurons of the somatosensory cortex 査読

    Risa Iguchi, Shinji Tanaka, Shigeo Okabe

    154   27 - 34   2020年5月

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    担当区分:筆頭著者   記述言語:英語  

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  • Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice 査読 国際誌

    Te-Chen Tzeng, Yuto Hasegawa, Risa Iguchi, Amy Cheung, Daniel R. Caffrey, Elizabeth Jeanne Thatcher, Wenjie Mao, Gail Germain, Nelsy DePaula Tamburro, Shigeo Okabe, Michael T. Heneka, Eicke Latz, Kensuke Futai, Douglas T. Golenbock

    Proceedings of the National Academy of Sciences of the United States of America   115 ( 36 )   9002 - 9007   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Alzheimer's disease (AD) is characterized by the progressive destruction and dysfunction of central neurons. AD patients commonly have unprovoked seizures compared with age-matched controls. Amyloid peptide-related inflammation is thought to be an important aspect of AD pathogenesis. We previously reported that NLRP3 inflammasome KO mice, when bred into APPswe/PS1ΔE9 (APP/PS1) mice, are completely protected from amyloid-induced AD-like disease, presumably because they cannot produce mature IL1β or IL18. To test the role of IL18, we bred IL18KO mice with APP/PS1 mice. Surprisingly, IL18KO/APP/PS1 mice developed a lethal seizure disorder that was completely reversed by the anticonvulsant levetiracetam. IL18-deficient AD mice showed a lower threshold in chemically induced seizures and a selective increase in gene expression related to increased neuronal activity. IL18-deficient AD mice exhibited increased excitatory synaptic proteins, spine density, and basal excitatory synaptic transmission that contributed to seizure activity. This study identifies a role for IL18 in suppressing aberrant neuronal transmission in AD.

    DOI: 10.1073/pnas.1801802115

    PubMed

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  • 中枢神経系シナプス形成の多様性の分子基盤

    井口理沙, 岩崎広英, 岡部繫男

    89 ( 1 )   77 - 80   2017年

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担当経験のある授業科目

  • 学問の扉 知と方法の最前線

    2022年
    -
    現在
    機関名:新潟大学