2024/03/29 更新

写真a

タカハシ カズヤ
高橋 一也
TAKAHASHI Kazuya
所属
医歯学総合病院 消化器内科 助教
職名
助教
外部リンク

学位

  • 博士(医学) ( 2016年3月 )

経歴

  • 新潟大学   医歯学総合病院 消化器内科   助教

    2022年9月 - 現在

  • 新潟大学   医歯学総合研究科   特任助教

    2021年4月 - 2022年8月

 

論文

  • Achalasia phenotypes and prediction of per-oral endoscopic myotomy outcomes using machine learning. 国際誌

    Kazuya Takahashi, Hiroki Sato, Yuto Shimamura, Hirofumi Abe, Hironari Shiwaku, Junya Shiota, Chiaki Sato, Kenta Hamada, Masaki Ominami, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Shuji Terai, Haruhiro Inoue

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   2023年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: High-resolution manometry (HRM) and esophagography are used for achalasia diagnosis; however, achalasia phenotypes combining esophageal motility and morphology are unknown. Moreover, predicting treatment outcomes of per-oral endoscopic myotomy (POEM) in treatment-naïve patients remains an unmet need. METHODS: In this multicenter cohort study, we included 1,824 treatment-naïve patients diagnosed with achalasia. In total, 1,778 patients underwent POEM. Clustering by machine learning (ML) was conducted to identify achalasia phenotypes using patients' demographic data, including age, sex, disease duration, body mass index, and HRM/esophagography findings. ML models were developed to predict persistent symptoms (Eckardt score ≥3) and reflux esophagitis (RE) (Los Angeles grades A to D) after POEM. RESULTS: ML identified three achalasia phenotypes: phenotype 1, type I achalasia with a dilated esophagus (n=676; 37.0%); phenotype 2, type II achalasia with a dilated esophagus (n=203; 11.1%); phenotype 3, late-onset type I-III achalasia with a non-dilated esophagus (n=619, 33.9%). Types I and II achalasia in phenotypes 1 and 2 exhibited different clinical characteristics from those in phenotype 3, implying different pathophysiologies within the same HRM diagnosis. A predictive model for persistent symptoms exhibited an area under the curve (AUC) of 0.70. Pre-POEM Eckardt score ≥6 was the greatest contributing factor for persistent symptoms. The AUC for post-POEM RE was 0.61. CONCLUSION: Achalasia phenotypes combining esophageal motility and morphology indicated multiple disease pathophysiologies. ML helped develop an optimal risk stratification model for persistent symptoms with novel insights into treatment resistance factors.

    DOI: 10.1111/den.14714

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  • Development and validation of machine learning model for predicting treatment responders in patients with primary biliary cholangitis. 国際誌

    Naruhiro Kimura, Kazuya Takahashi, Toru Setsu, Yusuke Horibata, Yusuke Kaneko, Haruka Miyazaki, Kohei Ogawa, Yuzo Kawata, Norihiro Sakai, Yusuke Watanabe, Hiroyuki Abe, Hiroteru Kamimura, Akira Sakamaki, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

    Hepatology research : the official journal of the Japan Society of Hepatology   2023年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIMS: Ursodeoxycholic acid is the first-line treatment for primary biliary cholangitis, and treatment response is one of the factors predicting the outcome. To prescribe alternative therapies, clinicians might need additional information before deciphering the treatment response to ursodeoxycholic acid, contributing to a better patient prognosis. In this study, we developed and validated machine learning (ML) algorithms to predict treatment responses using pretreatment data. METHODS: This multicenter cohort study included collecting datasets from two data samples. Data 1 included 245 patients from 18 hospitals for ML development, and was divided into (i) training and (ii) development sets. Data 2 (iii: test set) included 51 patients from our hospital for validation. An extreme gradient boosted tree predicted the treatment response in the ML model. The area under the curve was used to evaluate the efficacy of the algorithm. RESULTS: Data 1 showed that patients complying with the Paris II treatment response had significantly lower serum alkaline phosphatase and total bilirubin levels than those who did not respond. Three factors, total bilirubin, total protein, and alanine aminotransferase levels were selected as essential variables for prediction. Data 2 showed that patients complying with the Paris II criteria had significantly high prothrombin time and low total bilirubin levels. The area under the curve of extreme gradient boosted tree was good for (ii) (0.811) and (iii) (0.856). CONCLUSIONS: We demonstrated the efficacy of ML in predicting the treatment response for patients with primary biliary cholangitis. Early identification of cases requiring additional treatment with our novel ML model may improve prognosis.

    DOI: 10.1111/hepr.13966

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  • Machine learning prediction model for treatment responders in patients with primary biliary cholangitis. 国際誌

    Naruhiro Kimura, Kazuya Takahashi, Toru Setsu, Shu Goto, Suguru Miida, Nobutaka Takeda, Yuichi Kojima, Yoshihisa Arao, Kazunao Hayashi, Norihiro Sakai, Yusuke Watanabe, Hiroyuki Abe, Hiroteru Kamimura, Akira Sakamaki, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

    JGH open : an open access journal of gastroenterology and hepatology   7 ( 6 )   431 - 438   2023年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND AIM: Treatment response to ursodeoxycholic acid may predict the prognosis of patients with primary biliary cholangitis (PBC). Recent studies have suggested the benefits of using machine learning (ML) to forecast complex medical predictions. We aimed to predict treatment response in patients with PBC using ML and pretreatment data. METHODS: We conducted a single-center retrospective study and collected data from 194 patients with PBC who were followed up for at least 12 months after treatment initiation. Patient data were analyzed with five ML models, namely random forest, extreme gradient boosting (XGB), decision tree, naïve Bayes, or logistic regression, to predict treatment response using the Paris II criteria. The established models were assessed using an out-of-sample validation. The area under the curve (AUC) was used to evaluate the efficacy of each algorithm. Overall survival and liver-related deaths were analyzed using Kaplan-Meier analysis. RESULTS: Compared to logistic regression (AUC = 0.595, P = 0.0219, 0.031 models), ML analyses showed significantly high AUC in the random forest (AUC = 0.84) and XGB (AUC = 0.83) models; however, the AUC was not significantly high for decision tree (AUC = 0.633) or naïve Bayes (AUC = 0.584) models. Kaplan-Meier analysis showed significantly improved prognoses in patients predicted to achieve the Paris II criteria by XGB (log-rank = 0.005 and 0.007). CONCLUSION: ML algorithms could improve treatment response prediction using pretreatment data, which could lead to better prognoses. In addition, the ML model using XGB could predict the prognosis of patients before treatment initiation.

    DOI: 10.1002/jgh3.12915

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  • Utility of autologous fecal microbiota transplantation and elucidation of microbiota in diversion colitis. 国際誌

    Kentaro Tominaga, Atsunori Tsuchiya, Takeshi Mizusawa, Asami Matsumoto, Ayaka Minemura, Kentaro Oka, Motomichi Takahashi, Tomoaki Yoshida, Yuichi Kojima, Kohei Ogawa, Yuzo Kawata, Nao Nakajima, Naruhiro Kimura, Hiroyuki Abe, Toru Setsu, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Ken-Ichi Mizuno, Junji Yokoyama, Yosuke Tajima, Masato Nakano, Yoshifumi Shimada, Hitoshi Kameyama, Toshifumi Wakai, Shuji Terai

    DEN open   2 ( 1 )   e63   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Objectives: Diversion colitis (DC) is an inflammatory disorder caused by interruption of the fecal stream and subsequent nutrient deficiency from luminal bacteria. The utility of fecal microbiota transplantation (FMT) for DC was recently investigated; however, the precise pathogenesis of this condition remains unclear. This study aimed to evaluate the utility of autologous FMT in DC and to determine the related changes in the intestinal microbiota. Methods: Autologous FMT was performed to reestablish the intestinal microbiota in five patients (average age, 64.6 ± 8.3 years) with DC. They underwent double-ended colostomy. We assessed the diverted colon by endoscopy and evaluated the microbiota before and after FMT using the 16S rRNA gene sequencing method. Results: All five patients had mild inflammation (ulcerative colitis endoscopic index of severity [UCEIS] 2-3) in the diverted colon based on the colonoscopic findings. Three patients presented with symptoms, such as tenesmus, mucoid stool, and bloody stool. With FMT treatment, all patients achieved endoscopic remission (UCEIS score of 0 or 1) and symptomatic improvement. We observed a significantly decreased α-diversity in DC patients compared to healthy controls. The frequency of aerobic bacteria, such as Enterobacteriaceae, in the diverted colon decreased after autologous FMT. Conclusions: This study was the first to show that the microbiota in the diverted colon was significantly affected by autologous FMT. Since interruption of the fecal stream is central to the development of DC, FMT can be considered a promising treatment.

    DOI: 10.1002/deo2.63

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  • Intestinal duplication diagnosed preoperatively with double-balloon enteroscopy: an extremely rare case report and literature review.

    Yusuke Niwa, Kentaro Tominaga, Yuzo Kawata, Takamasa Kobayashi, Takeshi Mizuwasa, Kazuya Takahashi, Hiroki Sato, Junji Kohisa, Satoshi Abe, Kenya Kamimura, Junji Yokoyama, Hirokazu Kawai, Hideaki Sugino, Hajime Umezu, Yumiko Hirai, Masato Nakano, Yoshifumi Shimada, Hitoshi Kameyama, Toshifumi Wakai, Shuji Terai

    Clinical journal of gastroenterology   15 ( 2 )   381 - 387   2022年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Gastrointestinal duplications are congenital malformations that are usually observed in pediatric patients. Diagnosis in adulthood is quite rare, and preoperative diagnosis of gastrointestinal duplication is difficult, particularly in the small intestine. We encountered an extremely rare adult case of duplication of the jejunum, which showed a stomach-like form diagnosed using double-balloon enteroscopy (DBE). The patient was an 18-year-old male who had been experiencing upper abdominal pain and vomiting repeatedly without any triggers for 3 years. Various examinations were performed, but no cause of symptoms was found. DBE revealed a narrow opening of the lumen at the upper jejunum, and the lumen was covered with mucosal folds similar to those of the stomach. Enteroclysis via DBE showed a tubular structure on the mesenteric side of the jejunum. We diagnosed a jejunal tubular duplication with ectopic gastric mucosa and underwent partial small bowel resection. The patient's abdominal symptoms resolved. From this, DBE can be a useful tool for diagnosing intestinal duplication in adults. We believe that this case and literature review will facilitate the accurate and prompt diagnosis of small intestinal duplication.

    DOI: 10.1007/s12328-022-01596-7

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  • Esophageal Diverticulum - Indications and Efficacy of Therapeutic Endoscopy.

    Hiroki Sato, Manabu Takeuchi, Kazuya Takahashi, Ken-Ichi Mizuno, Koichi Furukawa, Akito Sato, Nao Nakajima, Junji Yokoyama, Shuji Terai

    Internal medicine (Tokyo, Japan)   61 ( 7 )   943 - 949   2022年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Objective Esophageal diverticulum is rare, and the concomitance of esophageal motility disorders (EMDs) and the efficacy of novel endoscopic treatment have not been investigated in Japan. Methods An examination including high-resolution manometry (HRM) was performed for patients with both EMDs and epiphrenic diverticulum. EMD-related epiphrenic diverticulum and Zenker's diverticulum were treated using salvage peroral endoscopic myotomy (s-POEM) and endoscopic diverticulotomy, respectively. Results Six cases of epiphrenic diverticulum were diagnosed in this study. Among 125 patients with achalasia and spastic disorders, concomitant epiphrenic diverticulum was observed in 4 (3.2%). Of these, three showed a normal lower esophageal sphincter pressure on HRM, although gastroscopy and esophagography revealed typical findings of an impaired lower esophageal sphincter relaxation. These four patients were successfully treated with s-POEM, and the Eckardt score improved from 6.3 to 0.25 at 32.5 (range: 13-56) months of follow-up, with equivalent treatment efficacy to that observed for achalasia and spastic disorders without epiphrenic diverticulum. In contrast, the two remaining cases of epiphrenic diverticulum had normal esophageal motility. Six cases of Zenker's diverticulum were diagnosed, and endoscopic diverticulotomy was successfully performed in all. The dysphagia score decreased from 2.8 to 0.17 at 14.8 (range: 2-36) months of follow-up. Overall, 12 endoscopic treatments were performed for esophageal diverticulum; no adverse events were observed. Conclusion In epiphrenic diverticulum patients, concomitant EMDs are not rare and should be carefully diagnosed. A normal lower esophageal sphincter pressure on HRM does not always mean a normal lower esophageal sphincter relaxation. S-POEM and endoscopic diverticulotomy are effective minimally invasive treatment options for EMD-related epiphrenic diverticulum and Zenker's diverticulum.

    DOI: 10.2169/internalmedicine.8196-21

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  • Hydrogen-producing small intestinal bacterial overgrowth is associated with hepatic encephalopathy and liver function. 国際誌

    Kunihiko Yokoyama, Akira Sakamaki, Kazuya Takahashi, Takumi Naruse, Chihiro Sato, Yuzo Kawata, Kentaro Tominaga, Hiroyuki Abe, Hiroki Sato, Atsunori Tsuchiya, Kenya Kamimura, Masaaki Takamura, Junji Yokoyama, Shuji Terai

    PloS one   17 ( 2 )   e0264459   2022年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Overt hepatic encephalopathy (HE) is one of the complications of liver cirrhosis (LC), which negatively affects the prognosis and quality of life of patients. Small intestinal bacterial overgrowth (SIBO) is significantly associated with LC and its complications, including HE. We investigated the relationship between SIBO and LC, and the difference between hydrogen-producing and methane-producing SIBO (H-SIBO and M-SIBO, respectively). This is a prospective cohort study of 107 cases. Breath measurements of hydrogen and methane concentrations were performed for the diagnosis of SIBO. The study cohort included 81 males with a median age of 70 (40-86) years, and SIBO was detected in 31 cases (29.0%). There were no significant differences between the SIBO positive and SIBO negative groups. Reclassification into H-SIBO (16 cases) and others (91 cases) was performed, and the Child-Pugh score was only derived in the multivariate logistic analysis (P = 0.028, odds ratio 1.39, 95% confidence interval 1.04-1.85). Furthermore, H-SIBO was significantly associated with covert HE in chi-square test (50.0% vs. 24.2%, P = 0.034). In addition, we evaluated the therapeutic response on SIBO of rifaximin in eight covert HE patients. 20% patients with M-SIBO and 67% patients with H-SIBO showed an improvement of the breath test. In conclusion, H-SIBO, but not M-SIBO, is significantly associated with liver function, and rifaximin might be more effective for covert HE with H-SIBO. Therefore, the diagnosis of SIBO, including the classification as H-SIBO and M-SIBO, might help to determine the choice of treatment for HE.

    DOI: 10.1371/journal.pone.0264459

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  • Endoscopic Submucosal Dissection for Gastric Tube Carcinoma after Esophagectomy Contributes to Long-Term Outcomes. 国際誌

    Satoru Hashimoto, Hiroki Sato, Ken-Ichi Mizuno, Kazuya Takahashi, Masafumi Takatsuna, Junji Yokoyama, Hiroshi Ichikawa, Manabu Takeuchi, Masaaki Kobayashi, Shuji Terai

    Canadian journal of gastroenterology & hepatology   2022   1631415 - 1631415   2022年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The incidence of gastric tube carcinoma (GTC) after esophagectomy for esophageal carcinoma has increased in recent years. Surgical removal of the reconstructed gastric tube is associated with high mortality, and endoscopic submucosal dissection (ESD) is a promising alternative. There are limited reports of ESD for GTC. This study investigated the efficacy and safety of ESD in GTC. This single-center retrospective study examined patients who underwent ESD for GTC after esophagectomy at our institution between 2003 and 2018. The curability of GTC with ESD was evaluated histologically according to the Japanese Gastric Cancer Treatment Guidelines. Patient characteristics and procedural and long-term outcomes were analyzed. Overall, 31 patients (29 men and 2 women; median age, 73 years) with 45 GTC lesions underwent ESD. The mean period between primary esophagectomy and the diagnosis of GTC was 10.6 years. Bleeding during ESD was noted in two patients (6.5%). No other adverse or fatal events such as perforation were noted. Complete resection and curative resection were documented in 80.6% and 48.4% of cases, respectively. The 3-year and 5-year overall survival rates were 67.6% and 47.7%, respectively. The 3-year and 5-year disease-specific survival rates were 100% and 92.9%, respectively. One patient died of GTC, and fourteen patients died of other diseases, including primary carcinoma in five cases. ESD was safe and provided good long-term outcomes in patients with GTC. Regular long-term gastroscopy is required for the early detection of GTC. Patients with GTC after esophagectomy for esophageal carcinoma have a high risk of other primary carcinomas or comorbidities after ESD.

    DOI: 10.1155/2022/1631415

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  • New cine magnetic resonance imaging parameters for the differential diagnosis of chronic intestinal pseudo-obstruction. 国際誌

    Hiroki Sato, Hiroyuki Ogihara, Kazuya Takahashi, Yuzo Kawata, Yuichi Kojima, Kentaro Tominaga, Junji Yokoyama, Yoshihiko Hamamoto, Shuji Terai

    Scientific reports   11 ( 1 )   22974 - 22974   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Chronic intestinal pseudo-obstruction (CIPO) is a severe and refractory intestinal motility disorder whose diagnosis currently relies on subjective imaging assessments. Cine magnetic resonance imaging (MRI) may potentially improve the quantitative analysis of gastrointestinal motility; however, suitable CIPO detection parameters should be determined. Cine MRI was performed in seven patients with CIPO and 11 healthy controls. The logarithm of the Mahalanobis distance (x1) and distance variation per time (x2) were used as the original parameters to determine CIPO diagnostic thresholds. Furthermore, the correlation between cine MRI findings and CIPO severity was investigated. Threshold values of α = 1.10 and β = 0.15 for x1 and x2, respectively, produced a CIPO diagnosis sensitivity of 1.00 (7/7) and specificity of 0.82 (9/11). The resulting error was 0.11 (2/18). The two parameters were correlated (Pearson's correlation coefficient: - 0.52). Any of the intestinal tracts of patients with severe CIPO requiring home parenteral nutrition belonged to the region defined by x1 ≥ 1.10 and x2 ≤ 0.15. Cine MRI is effective for the quantitative evaluation of small intestinal motility and CIPO diagnosis when using the abovementioned parameters and can be useful for treatment decision-making. However, these parameters have a wide distribution in healthy volunteers; this may complicate the detection of other disorders.

    DOI: 10.1038/s41598-021-02268-1

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  • 潜在性肝性脳症は水素型SIBOに関連し、その治療にはリファキシミンが有効である

    坂牧 僚, 横山 邦彦, 高橋 一也, 成瀬 匠, 冨永 顕太郎, 佐藤 裕樹, 上村 顕也, 横山 純二, 寺井 崇二

    日本門脈圧亢進症学会雑誌   27 ( 3 )   176 - 176   2021年8月

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    記述言語:日本語   出版者・発行元:(一社)日本門脈圧亢進症学会  

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  • Evaluation of intestinal microbiota, short-chain fatty acids, and immunoglobulin a in diversion colitis. 国際誌

    Kentaro Tominaga, Atsunori Tsuchiya, Takeshi Mizusawa, Asami Matsumoto, Ayaka Minemura, Kentaro Oka, Motomichi Takahashi, Tomoaki Yosida, Yuzo Kawata, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Ken-Ichi Mizuno, Yosuke Tajima, Masato Nakano, Yoshifumi Shimada, Hitoshi Kameyama, Junji Yokoyama, Toshifumi Wakai, Shuji Terai

    Biochemistry and biophysics reports   25   100892 - 100892   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    It is reported that an increase in aerobic bacteria, a lack of short-chain fatty acids (SCFAs), and immune disorders in the diverted colon are major causes of diversion colitis. However, the precise pathogenesis of this condition remains unclear. The aim of the present study was to examine the microbiota, intestinal SCFAs, and immunoglobulin A (IgA) in the diverted colon. Eight patients underwent operative procedures for colostomies. We assessed the diverted colon using endoscopy and obtained intestinal samples from the diverted colon and oral colon in these patients. We analyzed the microbiota and SCFAs of the intestinal samples. The bacterial communities were investigated using a 16S rRNA gene sequencing method. The microbiota demonstrated a change in the proportion of some species, especially Lactobacillus, which significantly decreased in the diverted colon at the genus level. We also showed that intestinal SCFA values were significantly decreased in the diverted colon. Furthermore, intestinal IgA levels were significantly increased in the diverted colon. This study was the first to show that intestinal SCFAs were significantly decreased and intestinal IgA was significantly increased in the diverted colon. Our data suggest that SCFAs affect the microbiota and may play an immunological role in diversion colitis.

    DOI: 10.1016/j.bbrep.2020.100892

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  • Comparison of Oral and Esophageal Microbiota in Patients with Achalasia Before and After Peroral Endoscopic Myotomy. 国際誌

    Kazuya Takahashi, Hiroki Sato, Takeshi Mizusawa, Kentaro Tominaga, Satoshi Ikarashi, Kazunao Hayashi, Ken-Ichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Shuji Terai

    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology   32 ( 1 )   42 - 52   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND/AIMS: Patients with achalasia have a high incidence of esophageal squamous cell carcinoma (ESCC), which may be associated with alterations in oral and esophageal microbiota caused by food stasis. This study compared the oral and esophageal microbiota of patients with achalasia before and after peroral endoscopic myotomy (POEM). It also compared patients with achalasia to those with ESCC. MATERIALS AND METHODS: The study prospectively examined 6 patients with achalasia and 14 with superficial ESCC. Oral samples obtained from the buccal mucosa using a swab and esophageal samples obtained from the mid-esophagus using a brush via endoscopy were analyzed by 16S rRNA metagenome sequencing. Additionally, endoscopic and histological findings of patients with achalasia before and after POEM were prospectively compared. RESULTS: In patients with achalasia, Streptococcus was most abundant in both the oral and the esophageal microbiota, and these microbiota were significantly different. Although the overall structure of the oral and esophageal microbiota did not change after POEM, the relative abundance rate of Haemophilus and Neisseria increased in the esophagus, and endoscopic findings of inflammation improved after POEM (P = .04). The relative abundance of microbiota was not different among patients with achalasia from those with ESCC. CONCLUSIONS: The oral and esophageal microbiota were significantly different in patients with achalasia, and some of the composition of the esophageal microbiota changed after POEM. However, these findings and disease-specific microbiota should be further evaluated in large-scale studies.

    DOI: 10.5152/tjg.2020.19995

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  • Esophageal Ulcers Associated with Ulcerative Colitis: A Case Series and Literature Review.

    Kentaro Tominaga, Atsunori Tsuchiya, Hiroki Sato, Takeshi Mizusawa, Shinichi Morita, Yui Ishii, Nobutaka Takeda, Kazuki Natsui, Yuzo Kawata, Naruhiro Kimura, Yoshihisa Arao, Kazuya Takahashi, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    Internal medicine (Tokyo, Japan)   59 ( 16 )   1983 - 1989   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Ulcerative colitis, a chronic and recurrent inflammatory disease, is localized to the colonic mucosa but can affect other organs and lead to various complications. Gastroduodenitis associated with ulcerative colitis has been reported. However, little is known about esophageal ulcers. We herein report two rare cases of esophageal ulcers associated with ulcerative colitis. Furthermore, the clinical and histological characteristics of 18 previously reported cases are summarized. This case series and literature review will encourage the accurate diagnosis and treatment of esophageal ulcers associated with ulcerative colitis.

    DOI: 10.2169/internalmedicine.4437-20

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  • A rare case of peliosis hepatis in a patient with chronic renal failure and renal cell carcinoma.

    Hiroki Maruyama, Kazuya Takahashi, Natsuki Ishikawa, Kazunori Hosaka, Daisuke Kumaki, Yukio Aruga, Masashi Yamakawa, Masaaki Hirano, Kazuhiro Funakoshi, Shuji Terai

    Clinical journal of gastroenterology   13 ( 3 )   403 - 407   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Peliosis hepatis (PH) is a rare disease characterized by the presence of sinusoidal dilation and blood-filled cysts throughout the hepatic parenchyma. We report a case of PH in a 49-year-old woman with chronic renal failure (CRF) on hemodialysis and with renal cell carcinoma (RCC). Dynamic contrast-enhanced computed tomography (CT) showed a 35-mm-diameter, hypervascular tumor in the liver and RCC in the right renal cyst. Ultrasound and superparamagnetic iron oxide-enhanced magnetic resonance imaging were also performed; however, the liver tumor could not be distinguished from the metastasis of RCC. Therefore, echo-guided biopsy of the liver tumor using an 18-G Majima needle was performed. Histological evaluation of the specimen showed irregular sinusoidal dilatation and blood-filled cavities without malignant cells. She was ultimately diagnosed with PH. Subsequently, she underwent total right nephrectomy for RCC and was diagnosed with RCC stage 1 (pT1N0M0). A follow-up CT performed 4 months after nephrectomy showed no growth of PH. Although the development of PH in patients with CRF or RCC who do not undergo renal transplantation is extremely rare, it should be considered in the differential diagnosis to distinguish PH from the metastasis of RCC.

    DOI: 10.1007/s12328-019-01068-5

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  • Efficacy of gelatin hydrogels incorporating triamcinolone acetonide for prevention of fibrosis in a mouse model. 国際誌

    Nao Nakajima, Satoru Hashimoto, Hiroki Sato, Kazuya Takahashi, Takuro Nagoya, Kenya Kamimura, Atsunori Tsuchiya, Junji Yokoyama, Yuichi Sato, Hanako Wakatsuki, Masayuki Miyata, Yusuke Akashi, Ryusuke Tanaka, Ken Matsuda, Yasuhiko Tabata, Shuji Terai

    Regenerative therapy   11   41 - 46   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Introduction: Triamcinolone acetonide (TA), a steroid, is often used clinically to prevent dysfunctions associated with fibrosis. The objective of this study was to examine whether TA can be suspended in a gelatin sheet for tissue engineering using a mouse skin wound model. Methods: TA was suspended in biodegradable gelatin and freeze-dried in a sheet form. The sheet was analyzed for homogeneity and controlled release of TA by high-performance liquid chromatography. We made two skin wounds on the dorsal side of mice. Gelatin sheets with TA (TA sheet) and without TA (control sheet) were attached to each skin wound. To determine the efficacy of the prepared TA sheet on the skin wounds, TA-sheet versus TA-injection experiments were conducted. Hematoxylin and eosin staining was performed to assess the grade of epithelialization and alpha smooth muscle actin (α-SMA) immunohistochemical staining was conducted to evaluate myofibroblast infiltration. Results: In the TA-release test in vitro, 7.7 ± 2.3% of TA was released from the sheet by 24 h. After replacing the initial phosphate-buffered saline (PBS) with collagenase PBS, the amount of released TA increased over time. The wound area/original skin wound area after 15 days with the TA sheet was significantly larger than that with the control sheet (26.9 ± 5.5% vs 10.7 ± 2.6%, p = 0.023). The α-SMA positive area/whole area with the TA sheet was significantly lower than that with the control sheet (4.65 ± 0.66% vs 7.24 ± 0.7%, p = 0.023). Furthermore, the α-SMA positive area/whole area with the TA sheet was significantly lower than that with TA injection (5.32 ± 0.45% vs 7.93 ± 0.75%, p = 0.013). Conclusions: We developed a TA sheet and confirmed both the homogeneity of the suspended TA and controlled-release of the TA in the presence of collagenase in vitro. The TA sheet caused less myofibroblast infiltration into the tissue than the control sheet or TA injection did.

    DOI: 10.1016/j.reth.2019.04.001

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  • A case of pancreatic pseudocysts accompanied by infection, pseudoaneurysm ruptures, and pseudocystocolonic fistulae.

    Kosuke Sato, Kazuya Takahashi, Yukio Aruga, Fusako Yamazaki, Daisuke Kumaki, Masashi Yamakawa, Masaaki Hirano, Kazuhiro Funakoshi, Shuji Terai

    Clinical journal of gastroenterology   12 ( 6 )   615 - 620   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Pancreatic pseudocysts (PPs) can be accompanied by infection, pseudoaneurysm ruptures, and fistulae to other organs, which can be fatal without appropriate treatment. Herein, we present the case of an 82-year-old man with PPs accompanied by infection, pseudoaneurysm rupture, and pseudocystocolonic fistula that were managed via multidisciplinary treatment. Computed tomography (CT) revealed two inflamed PPs, one each in the pancreatic head and tail. He was, therefore, diagnosed with infectious PPs. The pancreatic head PP shrunk on endoscopic nasopancreatic drainage (ENPD), but the pancreatic tail PP did not. Endoscopic ultrasound (EUS)-guided transluminal drainage was performed to treat the pancreatic tail PP; his symptoms improved. However, he vomited blood at 14 day post-drainage. Angiography revealed pseudoaneurysm rupture in a left gastric artery branch. After successful angioembolization, he developed hematochezia 2 days later. We suspected re-bleeding of the pseudoaneurysm. The bleeding stopped spontaneously, but CT and radiography revealed the presence of a pseudocystocolonic fistula. Careful follow-up was performed, and he has not had any symptoms at 9 month post-discharge. We managed PP-related complications via ENPD, EUS-guided transluminal drainage, angioembolization, and careful follow-up. Infection, pseudoaneurysm rupture, and pseudocystocolonic fistula are rare, but can occur simultaneously. Therefore, clinicians should consider these complications when treating patients with PPs.

    DOI: 10.1007/s12328-019-00986-8

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  • Duodenal and rectal obstructions due to urothelial cancer infiltration from recurrent renal pelvic cancer in the bladder wall: An autopsy case. 国際誌

    Takashi Ando, Kazuhiro Watanabe, Kazuya Takahashi, Takaki Mizusawa, Takeshi Sakai, Akiyoshi Katagiri

    Urology case reports   27   100903 - 100903   2019年11月

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    記述言語:英語  

    Duodenal and rectal obstructions due to urological malignancies are relatively uncommon. We report an autopsy case of an 83-year-old man with a history of renal pelvic cancer who presented these obstructions. Autopsy revealed that urothelial cancer infiltrated the bladder wall, duodenal wall, rectal wall, and prostate and widely spread in the retroperitoneal lymphatic vessel. We concluded that renal pelvic cancer recurred in the bladder wall and then infiltrated into each organ because of lymphatic dissemination. The gastrointestinal obstructions due to urinary tract cancer were lethal. Further knowledge and clinical experience regarding these types of obstructions are crucial.

    DOI: 10.1016/j.eucr.2019.100903

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  • Overlap in disease concept of functional esophageal disorders and minor esophageal motility disorders. 国際誌

    Hiroki Sato, Kazuya Takahashi, Ken-Ichi Mizuno, Satoru Hashimoto, Yuzo Kawata, Takeshi Mizusawa, Kentaro Tominaga, Junji Yokoyama, Shuji Terai

    Journal of gastroenterology and hepatology   34 ( 11 )   1940 - 1945   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND AIM: Functional gastrointestinal disorders are the most common disorders in gastroenterology and are currently considered as gut-brain interaction disorders with multiple related factors including motility disturbance. However, high-resolution manometry (HRM) had revealed a new disease concept known as minor esophageal motility disorders. This study aimed to investigate the correlation between functional esophageal disorders (FEDs) and minor esophageal motility disorders. METHODS: Functional esophageal disorders were diagnosed using upper endoscopy, pH monitoring, and HRM, to exclude achalasia, esophago-gastric junction outflow obstruction, and other major esophageal motility disorders. FEDs with or without minor esophageal motility disorders were compared using the Chicago classification. RESULTS: Twelve healthy volunteers also subjected to HRM showed no minor esophageal motility disorders. Of the 40 patients with FEDs, 15 (37.5%) were diagnosed with minor esophageal motility disorders. Characteristics were not different between patients with and without minor esophageal motility disorders (sex: P = 0.609, age: P = 0.054, body mass index: P = 0.137, and presence of psychiatric disorders: P = 0.404). The type and location of symptoms were not related to the comorbidity rate of minor esophageal motility disorders (P = 0.744 and 0.094). No patients with FEDs developed major esophageal motility disorders. CONCLUSIONS: Minor esophageal motility disorders were frequently observed in FEDs, but the causal relationship between esophageal symptoms remains unclear. The disease concepts of FEDs and minor esophageal motility disorders are considered to overlap and are both independent of major esophageal motility disorders.

    DOI: 10.1111/jgh.14691

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  • Methotrexate-Associated Lymphoproliferative Disorder: A Rare Case of Large Liver Tumors. 国際誌

    Saori Watanabe, Kazuya Takahashi, Kazuhiro Funakoshi, Shuji Terai

    Hepatology (Baltimore, Md.)   70 ( 2 )   748 - 750   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/hep.30606

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  • Epidemiological analysis of achalasia in Japan using a large-scale claims database.

    Hiroki Sato, Hiroshi Yokomichi, Kazuya Takahashi, Kentaro Tominaga, Takeshi Mizusawa, Naruhiro Kimura, Yuzo Kawata, Shuji Terai

    Journal of gastroenterology   54 ( 7 )   621 - 627   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Achalasia is a well-known esophageal motility disorder, but epidemiological studies in Japan are lacking. We investigated the incidence and period prevalence of achalasia in Japan, including the rate of coexistence of esophageal carcinoma, and evaluated treatment trends. METHODS: To estimate the nationwide number of patients with achalasia, a large-scale insurance claims database from 2005 to 2017 were used for our analyses. Patients with achalasia and coexistence of esophageal carcinoma were identified based on the diagnosis code registered. Interventional treatment was also evaluated. RESULTS: Of the total 5,493,650 populations, 385 were diagnosed with primary achalasia. The incidence was calculated as 0.81-1.37 per 100,000 person-years (male-to-female ratio was almost 1; mean age at diagnosis was 43.3 ± 14.4 years). The period prevalence was 7.0 per 100,000 persons. There were statistically significant trends of increase in the incidence and period prevalence over age groups (all p values < 0.0001). Four men with achalasia developed esophageal carcinoma, and the incidence of esophageal carcinoma with achalasia was estimated as 0.25 per 100 person-years. With regard to intervention, esophageal dilation was performed as a first treatment in 64.7% of patients, with repeat intervention required in 56.9% of these. The proportion of patients treated using peroral endoscopic myotomy (POEM) increased annually to 41.1% in 2017. CONCLUSIONS: In Japan, the incidence and period prevalence of achalasia is comparable to that in other countries. The absolute risk of esophageal carcinoma is rather low. Esophageal dilation has been the mainstay of achalasia treatment, and the role of POEM has increased annually.

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  • Evaluating the effect of injecting triamcinolone acetonide in two sessions for preventing esophageal stricture after endoscopic submucosal dissection. 国際誌

    Satoru Hashimoto, Ken-Ichi Mizuno, Kazuya Takahashi, Hiroki Sato, Junji Yokoyama, Manabu Takeuchi, Yuichi Sato, Masaaki Kobayashi, Shuji Terai

    Endoscopy international open   7 ( 6 )   E764-E770   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background and study aims  Several previous reports indicate that endoscopic injection of triamcinolone acetonide (TA) after widespread endoscopic submucosal dissection (ESD) is effective for preventing esophageal stricture. We investigated the efficacy of injecting TA in two sessions for preventing stricture formation post-ESD. Patients and methods  Sixty-six consecutive patients with widespread mucosal defects that affected more than three-fourths of the circumference of the esophagus were included. The study group (n = 40) received TA injections over two sessions: immediately after and 14 days after ESD. The control group (n = 26) did not receive a TA injection. This study was performed retrospectively against historical controls. The primary endpoint of this study was frequency of stricture after TA injection. The secondary endpoint was number of required endoscopic balloon dilations (EBDs) after TA injection. Results  The post-ESD stricture rate among patients who had subcircumferential mucosal defects was 45.7 % in the study group (16/35 patients), which was significantly lower than the rate of 73.9 % in the control group (17/23 patients; P  = 0.031). The number of EBD procedures required was significantly lower in the study group (median 0, range 0 - 7) than in the control group (median 4, range 0 - 20; P  < 0.001). There was no significant difference between the study and control groups among the patients who had full circumferential mucosal defects. Conclusion  This study showed that performing two sessions of TA injection is an effective and safe treatment for prevention of esophageal stricture following subcircumferential ESD.

    DOI: 10.1055/a-0894-4374

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  • ダブルバルーン内視鏡で診断に至った消化管重複症の成人例

    丹羽 佑輔, 上村 顕也, 小林 隆昌, 高橋 一也, 冨永 顕太郎, 河久 順志, 阿部 聡司, 川合 弘一, 横山 純二, 杉野 英明, 梅津 哉, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   35 ( 1 )   44 - 44   2019年6月

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    記述言語:日本語   出版者・発行元:(株)癌と化学療法社  

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  • A Case of Enteritis Induced by Nivolumab. 国際誌

    Takamasa Kobayashi, Kazuya Takahashi, Shuji Terai

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association   17 ( 6 )   A31-A32   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.cgh.2018.03.005

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  • Nivolumabに起因する自己免疫性小腸炎の一例

    石井 結唯, 小林 隆昌, 丹羽 佑輔, 高橋 一也, 冨永 顕太郎, 河久 順志, 阿部 聡司, 川合 弘一, 谷 優佑, 横山 純二, 寺井 崇二

    ENDOSCOPIC FORUM for digestive disease   34 ( 2 )   195 - 195   2018年12月

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    記述言語:日本語   出版者・発行元:(株)癌と化学療法社  

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  • ダブルバルーン内視鏡で診断に至った消化管重複症の成人例

    丹羽 佑輔, 上村 顕也, 小林 隆昌, 高橋 一也, 冨永 顕太郎, 河久 順志, 阿部 聡司, 川合 弘一, 横山 純二, 杉野 英明, 梅津 哉, 寺井 崇二

    日本消化器病学会甲信越支部例会・日本消化器内視鏡学会甲信越支部例会抄録集   63回・85回   59 - 59   2018年11月

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    記述言語:日本語   出版者・発行元:日本消化器病学会-甲信越支部  

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  • 術後胆汁中膵酵素値とERCP後膵炎の関連

    河久 順志, 五十嵐 聡, 林 和直, 荒生 祥尚, 阿部 寛幸, 高橋 一也, 渡邉 順, 横山 純二, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.2 )   2156 - 2156   2018年10月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • A case of Behçet's disease with various gastrointestinal findings.

    Kentaro Tominaga, Kenya Kamimura, Kazuya Takahashi, Junji Yokoyama, Shuji Terai

    Clinical journal of gastroenterology   11 ( 5 )   354 - 358   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Behçet's disease (BD) is a systemic inflammatory disorder involving the oral and genital mucosa, skin, eyes, gastrointestinal tract, joints, vasculature, and nervous. The gastrointestinal lesions accompanying with BD can extend along the full length of the tract, from the mouth to the anus, and show various clinical characteristics which is difficult to be differentiate from the other inflammatory bowel diseases including ulcerative colitis and Crohn's disease. Hence, the differential diagnosis is difficult and can affect treatment outcomes. We report here, a BD case showing varied gastrointestinal lesions and endoscopic findings. The information, endoscopic findings, differential diagnosis, and treatment approach in this case might help physicians to distinguish from other diseases and to manage similar cases.

    DOI: 10.1007/s12328-018-0860-6

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  • Gastric Cavernous Hemangioma Resected by Endoscopic Submucosal Dissection.

    Yusuke Watanabe, Kazuya Takahashi, Junji Yokoyama, Shuji Terai

    Internal medicine (Tokyo, Japan)   57 ( 15 )   2269 - 2270   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.0611-17

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  • Management decision based on lymphovascular involvement leads to favorable outcomes after endoscopic treatment of esophageal squamous cell carcinoma. 国際誌

    Kazuya Takahashi, Satoru Hashimoto, Ken-Ichi Mizuno, Takamasa Kobayashi, Kentaro Tominaga, Hiroki Sato, Junji Kohisa, Satoshi Ikarashi, Kazunao Hayashi, Manabu Takeuchi, Junji Yokoyama, Hirokazu Kawai, Yuichi Sato, Masaaki Kobayashi, Shuji Terai

    Endoscopy   50 ( 7 )   662 - 670   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Esophageal squamous cell carcinoma (ESCC) invading the muscularis mucosae (MM) and submucosa up to 200 µm (SM1) has a risk of metastasis. The aims of this study were to investigate the long-term outcome of endoscopic submucosal dissection (ESD) for MM/SM1 ESCC and to assess the management after ESD in our hospital. METHODS: This was a retrospective cohort study conducted at a single institution. Patients with MM or SM1 ESCC who were treated with ESD were included. Additional prophylactic therapy was added if lymphovascular involvement (LVI) was noted in the ESD specimens. RESULTS: A total of 102 patients were analyzed. The median length of follow-up was 71.5 months (range 9 - 144 months) and the median number of CTs was 6 (range 0 - 24). LVI was found in 21 patients (20.6 %), and 12 patients underwent additional prophylactic therapy. The 5-year overall survival, disease-specific survival, and tumor-free survival rates were 84.1 %, 97.5 %, and 82.1 %, respectively. A total of 26 patients died, but only 2 of them died from ESCC. The cumulative metastasis rate was 11.8 %, and LVI was a significant predictor of metastasis (hazard ratio 5.42, 95 % confidence interval 1.39 - 21.18; P = 0.02). There were no differences between patients with MM ESCC and those with SM1 ESCC. CONCLUSIONS: The long-term outcome after ESD for MM/SM1 ESCC was favorable with additional prophylactic therapy and strict adherence to follow-up. These results indicate that our management decision based on LVI is a valid approach and that ESD can be offered as a therapeutic option to MM/SM1 ESCCs.

    DOI: 10.1055/s-0043-124433

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  • Diversion colitis and pouchitis: A mini-review. 国際誌

    Kentaro Tominaga, Kenya Kamimura, Kazuya Takahashi, Junji Yokoyama, Satoshi Yamagiwa, Shuji Terai

    World journal of gastroenterology   24 ( 16 )   1734 - 1747   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Diversion colitis is characterized by inflammation of the mucosa in the defunctioned segment of the colon after colostomy or ileostomy. Similar to diversion colitis, diversion pouchitis is an inflammatory disorder occurring in the ileal pouch, resulting from the exclusion of the fecal stream and a subsequent lack of nutrients from luminal bacteria. Although the vast majority of patients with surgically-diverted gastrointestinal tracts remain asymptomatic, it has been reported that diversion colitis and pouchitis might occur in almost all patients with diversion. Surgical closure of the stoma, with reestablishment of gut continuity, is the only curative intervention available for patients with diversion disease. Pharmacologic treatments using short-chain fatty acids, mesalamine, or corticosteroids are reportedly effective for those who are not candidates for surgical reestablishment; however, there are no established assessment criteria for determining the severity of diversion colitis, and no management strategies to date. Therefore, in this mini-review, we summarize and review various recently-reported treatments for diversion disease. We are hopeful that the information summarized here will assist physicians who treat patients with diversion colitis and pouchitis, leading to better case management.

    DOI: 10.3748/wjg.v24.i16.1734

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  • Jackhammer Esophagus Accompanied by Esophageal Intramural Pseudodiverticulosis.

    Kazuya Takahashi, Satoshi Ikarashi, Junji Yokoyama, Shuji Terai

    Internal medicine (Tokyo, Japan)   57 ( 7 )   1051 - 1052   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.9734-17

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  • Esophageal motility disorders: new perspectives from high-resolution manometry and histopathology.

    Hiroki Sato, Kazuya Takahashi, Ken-Ichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Go Hasegawa, Shuji Terai

    Journal of gastroenterology   53 ( 4 )   484 - 493   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    High-resolution manometry (HRM) and peroral endoscopic myotomy (POEM) have contributed significantly to the field of esophageal motility disorders in recent years. The development of HRM has categorized various esophageal motility disorders with a focus on a diverse range of manometric anomalies. Additionally, the Chicago classification criteria is widely used for manometric diagnosis. Moreover, POEM was introduced as a minimally invasive radical therapy for achalasia and shows promise for other spastic esophageal motility disorders as well. POEM has also enabled a transluminal endoscopic approach for determining the histology of the esophageal muscle layer, which is expected to assist in elucidating the etiology of disorders associated with esophageal motility. The purpose of this review is to update the diagnosis, pathology, and treatment of esophageal motility disorders, with a focus on the recent advances in this field.

    DOI: 10.1007/s00535-017-1413-3

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  • IPMNの悪性診断における膵液細胞診の役割

    五十嵐 聡, 林 和直, 河久 順志, 冨永 顕太郎, 高橋 一也, 水野 研一, 橋本 哲, 横山 純二, 山際 訓, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.1 )   671 - 671   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • プロポフォールを用いた鎮静によるバルーン内視鏡下ERCPの現況

    河久 順志, 五十嵐 聡, 林 和直, 高橋 一也, 冨永 顕太郎, 水野 研一, 橋本 哲, 横山 純二, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.1 )   762 - 762   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • Efficacy of EUS for detection of a buried fish bone in the esophagus. 国際誌

    Junji Kohisa, Ken-Ichi Mizuno, Kazuya Takahashi, Junji Yokoyama, Shuji Terai

    VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy   3 ( 4 )   125 - 126   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.vgie.2018.02.002

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  • 内臓脂肪面積と生活習慣病、胆膵疾患、膵脂肪変性に関する検討

    河久 順志, 五十嵐 聡, 林 和直, 高橋 一也, 冨永 顕太郎, 水野 研一, 橋本 哲, 上村 博輝, 高村 昌昭, 横山 純二, 川合 弘一, 寺井 崇二

    日本消化器病学会雑誌   115 ( 臨増総会 )   A393 - A393   2018年3月

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    記述言語:日本語   出版者・発行元:(一財)日本消化器病学会  

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  • 当院における1型自己免疫性膵炎診療の現状と課題

    林 和直, 五十嵐 聡, 木村 成宏, 河久 順志, 高橋 一也, 冨永 顕太郎, 水野 研一, 橋本 哲, 横山 純二, 山際 訓, 寺井 崇二

    日本消化器病学会雑誌   115 ( 臨増総会 )   A299 - A299   2018年3月

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    記述言語:日本語   出版者・発行元:(一財)日本消化器病学会  

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  • 食道アカラシアの診断と治療戦略 経口内視鏡的筋層切開術(POEM)後に生じる逆流性食道炎の検討

    高橋 一也, 佐藤 裕樹, 冨永 顕太郎, 河久 順志, 五十嵐 聡, 林 和直, 水野 研一, 橋本 哲, 横山 純二, 寺井 崇二

    日本消化管学会雑誌   2 ( Suppl. )   135 - 135   2018年2月

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    記述言語:日本語   出版者・発行元:(一社)日本消化管学会  

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  • Full-layer mucosal histology in achalasia: Histological epithelial wave is characteristic in "pinstripe pattern"-positive achalasia. 査読

    Sato H, Takahashi K, Nakajima N, Hasegawa G, Mizuno K, Hashimoto S, Ikarashi S, Hayashi K, Honda Y, Yokoyama J, Sato Y, Terai S

    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society   30 ( 1 )   e13168 - e13168   2018年1月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/nmo.13168

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  • A clinical study of peroral endoscopic myotomy reveals that impaired lower esophageal sphincter relaxation in achalasia is not only defined by high-resolution manometry. 国際誌

    Hiroki Sato, Kazuya Takahashi, Ken-Ichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Shuji Terai

    PloS one   13 ( 4 )   e0195423   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND AIM: Achalasia is an esophageal motility disorder characterized by impaired lower esophageal sphincter (LES) relaxation. On high-resolution manometry (HRM), impaired LES relaxation is defined by elevated integrated relaxation pressure (IRP). However, a new category of achalasia within the normal IRP range has been suggested. METHODS: HRM was performed using a Starlet device and an IRP threshold of 26 mmHg. Peroral endoscopic myotomy (POEM) was performed for cases of achalasia diagnosed using established methods. During POEM, the histology of the LES was assessed. Follow-up was performed 2 months post-operatively. RESULTS: Forty-one patients with achalasia (18 women, mean age 53 ± 18.6 years) were included. Among them, 27 were placed in the IRP > 26 mmHg subgroup (impaired LES relaxation on HRM) and 14 in the IRP ≤ 26 mmHg subgroup (normal LES relaxation on HRM). In the IRP ≤ 26 mmHg subgroup, patients were older, had longer symptom duration, and had more esophageal dilation. The IRP ≤ 26 mmHg subgroup had the same symptom severity as the higher IRP subgroup and POEM significantly improved symptoms and IRP, although four patients still had severe LES fibrosis. CONCLUSIONS: The clinical presentation of achalasia has a gap between a HRM-defined impaired LES relaxation, with aging or disease progression considered reasons for a lowered LES pressure. POEM can be a feasible treatment option, even for cases of achalasia with a normal IRP. However, patients with severe LES fibrosis need more attention for the therapeutic indication.

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  • Endoscopic ultrasound-guided fine-needle aspiration for diagnosing a rare extraluminal duodenal gastrointestinal tumor. 国際誌

    Kazunao Hayashi, Kenya Kamimura, Kazunori Hosaka, Satoshi Ikarashi, Junji Kohisa, Kazuya Takahashi, Kentaro Tominaga, Kenichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Satoshi Yamagiwa, Kazuyasu Takizawa, Toshifumi Wakai, Hajime Umezu, Shuji Terai

    World journal of gastrointestinal endoscopy   9 ( 12 )   583 - 589   2017年12月

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    記述言語:英語  

    Duodenal gastrointestinal stromal tumors (GISTs) are extremely rare disease entities, and the extraluminal type is difficult to diagnose. These tumors have been misdiagnosed as pancreatic tumors; hence, pancreaticoduodenectomy has been performed, although partial duodenectomy can be performed if accurately diagnosed. Developing a diagnostic methodology including endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA) has allowed us to diagnose the tumor directly through the duodenum. Here, we present a case of a 50-year-old woman with a 27-mm diameter tumor in the pancreatic uncus on computed tomography scan. EUS showed a well-defined hypoechoic mass in the pancreatic uncus that connected to the duodenal proper muscular layer and was followed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). Histological examination showed spindle-shaped tumor cells positively stained for c-kit. Based on these findings, the tumor was finally diagnosed as a duodenal GIST of the extraluminal type, and the patient underwent successful mass resection with partial resection of the duodenum. This case suggests that EUS and EUS-FNA are effective for diagnosing the extraluminal type of duodenal GISTs, which is difficult to differentiate from pancreatic head tumor, and for performing the correct surgical procedure.

    DOI: 10.4253/wjge.v9.i12.583

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  • Changes in esophageal motility after endoscopic submucosal dissection for superficial esophageal cancer: a high-resolution manometry study. 査読

    Takahashi K, Sato Y, Takeuchi M, Sato H, Nakajima N, Ikarashi S, Hayashi K, Mizuno KI, Honda Y, Hashimoto S, Yokoyama J, Terai S

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus   30 ( 11 )   1 - 8   2017年11月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/dote/dox057

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  • Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis. 国際誌

    Hiroki Sato, Nao Nakajima, Kazuya Takahashi, Go Hasegawa, Ken-Ichi Mizuno, Satoru Hashimoto, Satoshi Ikarashi, Kazunao Hayashi, Yutaka Honda, Junji Yokoyama, Yuichi Sato, Shuji Terai

    World journal of gastroenterology   23 ( 13 )   2414 - 2423   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: To define clinical criteria to differentiate eosinophilic gastrointestinal disorder (EoGD) in the esophagus. METHODS: Our criteria were defined based on the analyses of the clinical presentation of eosinophilic esophagitis (EoE), subepithelial eosinophilic esophagitis (sEoE) and eosinophilic esophageal myositis (EoEM), identified by endoscopy, manometry and serum immunoglobulin E levels (s-IgE), in combination with histological and polymerase chain reaction analyses on esophageal tissue samples. RESULTS: In five patients with EoE, endoscopy revealed longitudinal furrows and white plaques in all, and fixed rings in two. In one patient with sEoE and four with EoEM, endoscopy showed luminal compression only. Using manometry, failed peristalsis was observed in patients with EoE and sEoE with some variation, while EoEM was associated with hypercontractile or hypertensive peristalsis, with elevated s-IgE. Histology revealed the following eosinophils per high-power field values. EoE = 41.4 ± 7.9 in the epithelium and 2.3 ± 1.5 in the subepithelium; sEoE = 3 in the epithelium and 35 in the subepithelium (conventional biopsy); EoEM = none in the epithelium, 10.7 ± 11.7 in the subepithelium (conventional biopsy or endoscopic mucosal resection) and 46.8 ± 16.5 in the muscularis propria (peroral esophageal muscle biopsy). Presence of dilated epithelial intercellular space and downward papillae elongation were specific to EoE. Eotaxin-3, IL-5 and IL-13 were overexpressed in EoE. CONCLUSION: Based on clinical and histological data, we identified criteria, which differentiated between EoE, sEoE and EoEM, and reflected a different pathogenesis between these esophageal EoGDs.

    DOI: 10.3748/wjg.v23.i13.2414

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  • Long-term outcomes of colorectal endoscopic submucosal dissection in elderly patients. 国際誌

    Yoshifumi Takahashi, Ken-Ichi Mizuno, Kazuya Takahashi, Hiroki Sato, Satoru Hashimoto, Manabu Takeuchi, Masaaki Kobayashi, Junji Yokoyama, Yuichi Sato, Shuji Terai

    International journal of colorectal disease   32 ( 4 )   567 - 573   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND AIMS: The safety and efficacy of endoscopic submucosal dissection (ESD) in elderly patients remain unclear. The aim of this study is to clarify the short- and long-term outcomes of colorectal ESD in elderly patients. PATIENTS AND METHODS: A total of 482 consecutive patients with 501 colorectal lesions treated with ESD from February 2005 to December 2013 were retrospectively reviewed. Patients were divided into two groups: an elderly group (≥ 75 years of age) and a non-elderly group (< 75 years of age). Short-term outcomes of interest were procedure time, complication rate, hospital stay, en bloc resection rate, and non-curative resection rate. Long-term outcomes of interest were disease-specific survival, and overall survival rates in the elderly group (51 patients) and non-elderly group (92 patients) were also analyzed. RESULTS: No significant differences were observed between the groups with respect to short-term outcomes. Two patients in each group required emergency surgery. Of the patients who underwent non-curative resection, 7/12 (58%) in the elderly group and 15/23 (65%) in the non-elderly group underwent additional surgery. The 5-year disease-specific survival rates in the elderly and non-elderly groups were both 100%, and the corresponding 5-year overall survival rates were 86.3 and 93.5%, respectively (p = 0.026). CONCLUSIONS: Short-term outcomes after colorectal ESD were equivalent in both groups, and all patients showed favorable long-term outcomes. Considering the benign prognosis of lesions resected with ESD, preoperative screening of comorbidities is essential to improve overall survival.

    DOI: 10.1007/s00384-016-2719-y

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  • Crohn病診療におけるMR enterographyの役割

    本田 穣, 横山 純二, 冨永 顕太郎, 高橋 一也, 西垣 佑紀, 五十嵐 聡, 林 和直, 水野 研一, 橋本 哲, 佐藤 祐一, 寺井 崇二

    日本消化器病学会雑誌   114 ( 臨増総会 )   A275 - A275   2017年3月

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    記述言語:日本語   出版者・発行元:(一財)日本消化器病学会  

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  • Muscle layer histopathology and manometry pattern of primary esophageal motility disorders including achalasia 査読

    N. Nakajima, H. Sato, K. Takahashi, G. Hasegawa, K. Mizuno, S. Hashimoto, Y. Sato, S. Terai

    NEUROGASTROENTEROLOGY AND MOTILITY   29 ( 3 )   2017年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    BackgroundHistopathology of muscularis externa in primary esophageal motility disorders has been characterized previously. We aimed to correlate the results of high-resolution manometry with those of histopathology.
    MethodsDuring peroral endoscopic myotomy, peroral esophageal muscle biopsy was performed in patients with primary esophageal motility disorders. Immunohistochemical staining for c-kit was performed to assess the interstitial cells of Cajal (ICCs). Hematoxylin Eosin and Azan-Mallory staining were used to detect muscle atrophy, inflammation, and fibrosis, respectively.
    Key ResultsSlides from 30 patients with the following motility disorders were analyzed: achalasia (type I: 14, type II: 5, type III: 3), one diffuse esophageal spasm (DES), two outflow obstruction (OO), four jackhammer esophagus (JE), and one nutcracker esophagus (NE). ICCs were preserved in high numbers in type III achalasia (n=9.41.2 cells/high power field [HPF]), compared to types I (n=3.7 +/- 0.3 cells/HPF) and II (n=3.5 +/- 1.0 cells/HPF). Moreover, severe fibrosis was only observed in type I achalasia and not in other types of achalasia, OO, or DES. Four of five patients with JE and NE had severe inflammation with eosinophilic infiltration of the esophageal muscle layer (73.8 +/- 50.3 eosinophils/HPF) with no epithelial eosinophils. One patient with JE showed a visceral myopathy pattern.
    Conclusions & InferencesCompared to types I and II, type III achalasia showed preserved ICCs, with variable data regarding DES and OO. In disorders considered as primary esophageal motility disorders, a disease category exists, which shows eosinophilic infiltration in the esophageal muscle layer with no eosinophils in the epithelium.

    DOI: 10.1111/nmo.12968

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  • Loss of peristalsis of the esophagus due to diffuse esophageal leiomyomatosis. 国際誌

    Kazuya Takahashi, Yui Ishii, Kazunao Hayashi, Satoshi Ikarashi, Hirokazu Kawai, Yuichi Sato, Shuji Terai

    Endoscopy   49 ( S 01 )   E95-E96   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1055/s-0043-100691

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  • An Unusual Case of an Extremely Large α-Fetoprotein-Producing Tumor. 国際誌

    Kazuya Takahashi, Atsunori Tsuchiya, Shuji Terai

    Gastroenterology   151 ( 6 )   1077 - 1080   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1053/j.gastro.2016.08.018

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  • Vonoprazan 20 mg vs lansoprazole 30 mg for endoscopic submucosal dissection-induced gastric ulcers. 国際誌

    Kazuya Takahashi, Yuichi Sato, Junji Kohisa, Jun Watanabe, Hiroki Sato, Kenichi Mizuno, Satoru Hashimoto, Shuji Terai

    World journal of gastrointestinal endoscopy   8 ( 19 )   716 - 722   2016年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: To compare the healing effects of vonoprazan and lansoprazole on gastric ulcers induced by endoscopic submucosal dissection (ESD). METHODS: Data were obtained from a total of 26 patients. Fourteen patients were randomized to the vonoprazan group and 12 were randomized to the lansoprazole group. Patients were administered either 20 mg vonoprazan or 30 mg lansoprazole per day after ESD. Endoscopic images just after ESD, on day 8, and on day 28 were used for the evaluation of the shrinking rate of ESD ulcers. The shrinking rates and the incidence of delayed bleeding were compared between the 2 groups. RESULTS: The shrinking rates of ESD ulcers on day 8 [vonoprazan group: 61.8% (range: 24.0%-91.1%), lansoprazole group: 71.3% (range: 25.2%-88.6%)] and on day 28 [vonoprazan group: 95.3% (range: 76.2%-100%), lansoprazole group: 97.2% (range: 81.1%-99.8%)] were not statistically different between the 2 groups. On day 28, most of the ulcers in both groups healed to more than 90%, whereas 3 of 14 (21.4%) in the vonoprazan group and 1 of 12 (8.3%) in the lansoprazole group had delayed ulcer healing, which was not statistically different (P = 0.356). The frequency of delayed bleeding was 0 in the both groups. Taken together, there were no significant differences between the two drug groups. CONCLUSION: Our study indicates that vonoprazan is potent for the management of ESD ulcers although lansoprazole is also sufficient and cost-effective.

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  • Endoscopic Removal of Ingested Dentures and Dental Instruments: A Retrospective Analysis. 国際誌

    Ken-Ichi Mizuno, Kazuya Takahashi, Kentaro Tominaga, Yuki Nishigaki, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Takashi Yamamoto, Yutaka Honda, Satoru Hashimoto, Kenya Kamimura, Manabu Takeuchi, Junji Yokoyama, Yuichi Sato, Masaaki Kobayashi, Shuji Terai

    Gastroenterology research and practice   2016   3537147 - 3537147   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background. Dentures and dental instruments are frequently encountered ingested foreign bodies. The aim of the present study was to assess the safety and efficacy of endoscopically removing ingested dental objects. Methods. Twenty-nine consecutive patients with 29 dental objects who were treated at the Niigata University Medical and Dental Hospital from August 2009 to December 2015 were retrospectively reviewed. Characteristics of the patients and the ingested dental objects, the clinical features and findings of radiological imaging tests, and outcomes of endoscopic removal were analyzed. Results. Patients' mean age was 62.9 ± 21.0 years. The ingested dental objects included 23 dentures (13 crowns, 4 bridges, 4 partial dentures, and 2 other dentures) and 6 dental instruments. Twenty-seven upper gastrointestinal endoscopies and 2 colonoscopies were performed, and their success rates were 92.6% and 100%, respectively. There were 2 cases of removal failure; one case involved an impacted partial denture in the cervical esophagus, and this case required surgical removal. Conclusions. Endoscopic removal of ingested dentures and dental instruments is associated with a favorable success rate and acceptable complications. The immediate intervention and appropriate selection of devices are essential for managing ingested dental objects.

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  • An unusual case of an esophageal functional disorder. 国際誌

    Kazuya Takahashi, Hiroki Sato, Yuichi Sato

    Gastroenterology   149 ( 6 )   e15-6   2015年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1053/j.gastro.2014.10.051

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  • Evaluation of esophageal motility after endoscopic submucosal dissection for superficial esophageal cancer. 国際誌

    Kazuya Takahashi, Manabu Takeuchi, Yuichi Sato, Hiroki Sato, Kenichi Mizuno, Satoru Hashimoto, Masaaki Kobayashi, Shuji Terai

    European journal of gastroenterology & hepatology   27 ( 10 )   1187 - 92   2015年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: Endoscopic submucosal dissection (ESD) is a standard treatment for superficial esophageal cancer. Some patients complain of dysphagia after ESD even without any postoperative strictures. Although ineffective esophageal motility might be associated with dysphagia after ESD, its effect on esophageal motility after ESD remains unknown. Therefore, we aimed to elucidate esophageal motility after ESD and the cause of dysphagia using high-resolution manometry (HRM). PATIENTS AND METHODS: Seventy-six patients (men/women, 64/12; mean age, 71.2 years) who had undergone ESD for superficial esophageal cancer were enrolled. The results of ESD were retrospectively investigated using endoscopic images from the ESD and patient questionnaire for dysphagia. Each patient underwent HRM, and the results were evaluated using metrics and contraction patterns, according to the Chicago classification. RESULTS: Data were obtained from 71 patients. The circumferential mucosal defect ratio (β=0.284, P=0.017), number of ESD (β=0.346, P=0.003), and number of endoscopic balloon dilatations (EBDs) (β=0.416, P<0.001) were correlated with the number of weak contraction with large breaks on HRM. The circumferential mucosal defect (odds ratio=1.074, P<0.001) and number of EBDs (odds ratio=1.200, P=0.035) were also significant predictors for dysphagia after ESD. CONCLUSION: Circumferential mucosal defect ratio, EBD, and repeated ESD were predictors for impaired esophageal motility after ESD. Because circumferential mucosal defect ratios and EBD were also correlated with dysphagia after ESD, impaired esophageal motility could explain dysphagia after ESD.

    DOI: 10.1097/MEG.0000000000000431

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  • Nutcracker and jackhammer esophagus treatment: a three-case survey, including two novel cases of eosinophilic infiltration into the muscularis propria. 国際誌

    Hiroki Sato, Manabu Takeuchi, Kazuya Takahashi, Yuichi Sato, Satoru Hashimoto, Kenichi Mizuno, Kenji Suzuki, Masaaki Kobayashi, Terasu Honma, Haruhiro Inoue, Shuji Terai

    Endoscopy   47 ( 9 )   855 - 7   2015年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Nutcracker esophagus and jackhammer esophagus are largely unknown motility disorders, also sometimes called hypertensive and hypercontractile peristalsis, respectively. There is currently no standardized diagnostic or management plan for these diseases. Here, we report on three patients with jackhammer/nutcracker esophagus who were treated with either peroral endoscopic myotomy or a systemic steroid regimen, focusing particularly on two novel presentations of nutcracker and jackhammer esophagus involving eosinophilic infiltration into the muscularis propria, and their responses to both interventions.

    DOI: 10.1055/s-0034-1391985

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  • Gastroenterology: A unique endoscopic technique for full-layer histology of jackhammer esophagus 査読

    H. Sato, G. Hasegawa, M. Takeuchi, K. Takahashi, Y. Sato, S. Hashimoto, K. Mizuno, M. Kobayashi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   30 ( 8 )   1226 - 1226   2015年8月

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    記述言語:英語   出版者・発行元:WILEY-BLACKWELL  

    DOI: 10.1111/jgh.12914

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  • Gastroenterology: Histopathological investigation of distal esophageal spasm (DES) using per-oral endoscopic myotomy (POEM) 査読

    K. Takahashi, H. Sato, Y. Sato, M. Takeuchi, S-R Takeda, K. Mizuno, S. Hashimoto, G. Hasegawa, M. Kobayashi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   30 ( 7 )   1113 - 1113   2015年7月

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    記述言語:英語   出版者・発行元:WILEY-BLACKWELL  

    DOI: 10.1111/jgh.12926

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  • Eosinophilic infiltration of the muscularis propria in a patient with jackhammer esophagus treated with per-oral endoscopic myotomy. 国際誌

    Hiroki Sato, Manabu Takeuchi, Kazuya Takahashi

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association   13 ( 4 )   e33-4   2015年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.cgh.2014.11.005

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  • Magnified endoscopic findings with a barnacle-like appearance in enterocolitis associated with sepsis. 国際誌

    Kazuya Takahashi, Yuichi Sato, Masato Hayakawa, Masaaki Takamura, Yutaka Aoyagi, Satoru Hashimoto, Masaaki Kobayashi, Gen Watanabe, Yoichi Ajioka

    Gastrointestinal endoscopy   81 ( 2 )   472 - 3   2015年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.gie.2014.09.026

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  • Salvage peroral endoscopic myotomy for esophageal diverticulum. 国際誌

    Hiroki Sato, Yuichi Sato, Manabu Takeuchi, Kazuya Takahashi, Shin-Ryu Takeda, Haruhiro Inoue, Masaaki Kobayashi

    Endoscopy   47 Suppl 1 UCTN   E14-5   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1055/s-0034-1390735

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  • Epiphrenic diverticulum of the esophagus after peroral endoscopic myotomy. 国際誌

    Hiroki Sato, Kazuya Takahashi, Manabu Takeuchi, Yuichi Sato, Satoru Hashimoto, Kenichi Mizuno, Shuji Terai

    Endoscopy   47 Suppl 1 UCTN   E509-10   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1055/s-0034-1393232

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  • Post-inflammatory Abdominal Pain in Patients with Inflammatory Bowel Disease during Remission: A Comprehensive Review

    Kazuya Takahashi, Iman Geelani Khwaja, Jocelyn Rachel Schreyer, David Bulmer, Madusha Peiris, Shuji Terai, Qasim Aziz

    Crohn's and Colitis 360   3 ( 4 )   2021年10月

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    掲載種別:書評論文,書評,文献紹介等  

    Patients with inflammatory bowel disease often experience ongoing pain even after achieving mucosal healing (i.e., post-inflammatory pain). Factors related to the brain-gut axis, such as peripheral and central sensitization, altered sympatho-vagal balance, hypothalamic-pituitary-adrenal axis activation, and psychosocial factors, play a significant role in the development of post-inflammatory pain. A comprehensive study investigating the interaction between multiple predisposing factors, including clinical psycho-physiological phenotypes, molecular mechanisms, and multi-omics data, is still needed to fully understand the complex mechanism of post-inflammatory pain. Furthermore, current treatment options are limited and new treatments consistent with the underlying pathophysiology are needed to improve clinical outcomes.

    DOI: 10.1093/crocol/otab073

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  • ダブルバルーン内視鏡で診断に至った消化管重複症の成人例

    丹羽佑輔, 上村顕也, 小林隆昌, 高橋一也, 冨永顕太郎, 河久順志, 阿部聡司, 川合弘一, 横山純二, 杉野英明, 梅津哉, 寺井崇二

    Endoscopic Forum for Digestive Disease   35 ( 1 )   2019年

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  • 超音波内視鏡における音速補正モードの有用性

    林 和直, 五十嵐 聡, 河久 順志, 高橋 一也, 冨永 顕太郎, 水野 研一, 橋本 哲, 横山 純二, 山際 訓, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.2 )   2110 - 2110   2018年10月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • ステロイド使用例における胆管結石治療の現状

    五十嵐 聡, 林 和直, 河久 順志, 冨永 顕太郎, 高橋 一也, 水野 研一, 橋本 哲, 横山 純二, 山際 訓, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.2 )   2086 - 2086   2018年10月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • ステロイド使用例における胆管結石治療の現状

    五十嵐 聡, 林 和直, 河久 順志, 冨永 顕太郎, 高橋 一也, 水野 研一, 橋本 哲, 横山 純二, 山際 訓, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.2 )   2086 - 2086   2018年10月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • 超音波内視鏡における音速補正モードの有用性

    林 和直, 五十嵐 聡, 河久 順志, 高橋 一也, 冨永 顕太郎, 水野 研一, 橋本 哲, 横山 純二, 山際 訓, 寺井 崇二

    Gastroenterological Endoscopy   60 ( Suppl.2 )   2110 - 2110   2018年10月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • IS ENDOSCOPIC SUBMUCOSAL DISSECTION A FEASIBLE TREATMENT FOR ESOPHAGOGASTRIC JUNCTION CANCER?

    Kazuya Takahashi, Satoru Hashimoto, Kenichi Mizuno, Hiroki Sato, Kentaro Tominaga, Junji Kohisa, Satoshi Ikarashi, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB396 - AB397   2018年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:MOSBY-ELSEVIER  

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  • IS ENDOSCOPIC SUBMUCOSAL DISSECTION VALUABLE FOR ELDERLY PATIENTS WITH SUPERFICIAL ESOPHAGEAL SQUAMOUS CELL CARCINOMA?

    Satoru Hashimoto, Kenichi Mizuno, Kazuya Takahashi, Hiroki Sato, Kentaro Tominaga, Junji Kohisa, Satoshi Ikarashi, Kazunao Hayashi, Junji Yokoyama, Shuji Terai

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB287 - AB287   2018年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:MOSBY-ELSEVIER  

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  • ENDOSCOPIC MANAGEMENT OF UNRESECTABLE MALIGNANT HILAR STRICTURES USING THREADED INSIDE STENTS VERSUS METALLIC STENTS

    Kazunao Hayashi, Satoshi Ikarashi, Junji Kohisa, Kazuya Takahashi, Kentaro Tominaga, Ken-ichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Satoshi Yamagiwa, Shuji Terai

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB208 - AB208   2018年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:MOSBY-ELSEVIER  

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  • SAFETY AND EFFICACY OF PROPOFOL-BASED SEDATION FOR BALLOON ENTEROSCOPE-ASSISTED ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY IN ELDERLY PATIENTS

    Junji Kohisa, Satoshi Ikarashi, Kazunao Hayashi, Kazuya Takahashi, Kentaro Tominaga, Kenichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Satoshi Yamagiwa, Shuji Terai

    GASTROINTESTINAL ENDOSCOPY   87 ( 6 )   AB229 - AB229   2018年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:MOSBY-ELSEVIER  

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  • 内臓脂肪面積と生活習慣病、胆膵疾患、膵脂肪変性に関する検討

    河久 順志, 五十嵐 聡, 林 和直, 高橋 一也, 冨永 顕太郎, 水野 研一, 橋本 哲, 上村 博輝, 高村 昌昭, 横山 純二, 川合 弘一, 寺井 崇二

    日本消化器病学会雑誌   115 ( 臨増総会 )   A393 - A393   2018年4月

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    記述言語:日本語   出版者・発行元:(一財)日本消化器病学会  

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  • Nivolumabに起因する自己免疫性小腸炎の一例

    石井結唯, 小林隆昌, 丹羽佑輔, 高橋一也, 冨永顕太郎, 河久順志, 阿部聡司, 川合弘一, 谷優佑, 横山純二, 寺井崇二

    Endoscopic Forum for Digestive Disease   34 ( 2 )   2018年

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  • 超音波内視鏡における音速補正モードの有用性

    林和直, 五十嵐聡, 河久順志, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

    Gastroenterological Endoscopy (Web)   60 ( Supplement2 )   2018年

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  • プロポフォールを用いた鎮静によるバルーン内視鏡下ERCPの現況

    河久順志, 五十嵐聡, 林和直, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 横山純二, 寺井崇二

    Gastroenterological Endoscopy (Web)   60 ( Supplement1 )   2018年

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  • 当院における1型自己免疫性膵炎診療の現状と課題

    林和直, 五十嵐聡, 木村成宏, 河久順志, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

    日本消化器病学会雑誌(Web)   115   2018年

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  • 内臓脂肪面積と生活習慣病,胆膵疾患,膵脂肪変性に関する検討

    河久順志, 五十嵐聡, 林和直, 高橋一也, 冨永顕太郎, 水野研一, 橋本哲, 上村博輝, 高村昌昭, 横山純二, 川合弘一, 寺井崇二

    日本消化器病学会雑誌(Web)   115   2018年

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  • ステロイド使用例における胆管結石治療の現状

    五十嵐聡, 林和直, 河久順志, 冨永顕太郎, 高橋一也, 水野研一, 橋本哲, 横山純二, 山際訓, 寺井崇二

    Gastroenterological Endoscopy (Web)   60 ( Supplement2 )   2018年

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  • 経口内視鏡的筋層切開術(POEM)後に生じる逆流性食道炎の検討

    高橋一也, 佐藤裕樹, 冨永顕太郎, 河久順志, 五十嵐聡, 林和直, 水野研一, 橋本哲, 横山純二, 寺井崇二

    日本消化管学会雑誌   2 ( Supplement )   2018年

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  • 食道巨大仮性憩室内に発生した扁平上皮癌の1例

    吉田 智彰, 橋本 哲, 高橋 一也, 廣瀬 奏恵, 竹内 卓, 林 和直, 水野 研一, 高村 昌昭, 佐藤 祐一, 寺井 崇二, 市川 寛, 羽入 隆晃, 渡辺 玄, 味岡 洋一, 梅津 哉

    ENDOSCOPIC FORUM for digestive disease   33 ( 2 )   125 - 125   2017年11月

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    記述言語:日本語   出版者・発行元:(株)癌と化学療法社  

    J-GLOBAL

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  • Long-Term Outcome of Endoscopic Submucosal Dissection in Esophageal Squamous Cell Carcinoma Invading Into the Muscularis Mucosa or Submucosa Up to 200 mu m

    Kazuya Takahashi, Satoru Hashimoto, Kenichi Mizuno, Hiroki Sato, Satoshi Ikarashi, Kazunao Hayashi, Yutaka Honda, Junji Yokoyama, Yuichi Sato, Shuji Terai

    GASTROINTESTINAL ENDOSCOPY   85 ( 5 )   AB108 - AB108   2017年5月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:MOSBY-ELSEVIER  

    DOI: 10.1016/j.gie.2017.03.161

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  • 内視鏡で観察しえた小腸小細胞癌の1例

    河久 順志, 荒生 祥尚, 阿部 寛幸, 高橋 一也, 渡邉 順, 大橋 瑠子, 味岡 洋一

    ENDOSCOPIC FORUM for digestive disease   33 ( 1 )   54 - 54   2017年5月

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    記述言語:日本語   出版者・発行元:(株)癌と化学療法社  

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  • 【粘膜、粘膜下層、さらに筋層の時代へ〜Minimally Invasive Treatmentの新たな潮流〜】粘膜下層に対するアプローチ Submucosal endoscopyによる筋層生検 経口内視鏡的食道筋層生検術(POEM-b)による新しい知見

    佐藤 裕樹, 高橋 一也, 中島 尚, 水野 研一, 橋本 哲, 五十嵐 聡, 林 和直, 本田 穣, 横山 純二, 佐藤 祐一, 本間 照, 寺井 崇二

    消化器内視鏡   29 ( 2 )   273 - 277   2017年2月

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    記述言語:日本語   出版者・発行元:(株)東京医学社  

    筆者らは経口内視鏡的筋層切開術(POEM)から経口内視鏡的食道筋層生検術(POEM-b)の着想を得て、本法を食道アカラシアなどの食道運動障害に対して施行してきた。これにより、食道アカラシアの食道内圧所見・罹病期間と消化管ペースメーカ細胞であるCajal介在細胞の関係性について明らかになりつつある。また、jackhammer食道やnutcracker食道などの食道運動障害の一部に、食道筋層への好酸球浸潤を特徴とする疾患があることが明らかになり、好酸球性食道筋炎(EoEM)と命名し報告した。POEM-bにより得られた新しい知見を紹介する。(著者抄録)

    J-GLOBAL

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  • 12 特異な経過をたどった肝細胞癌の1例(Ⅰ.一般演題, 第39回リバーカンファレンス)

    川田 雄三, 高村 昌昭, 井上 良介, 荒生 祥尚, 高橋 一也, 本田 博樹, 影向 一美, 橋本 哲, 佐藤 祐一, 野本 実, 坂田 純, 若井 俊文, 青柳 豊, 寺井 崇二

    新潟医学会雑誌   129 ( 10 )   618 - 618   2015年10月

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    記述言語:日本語   出版者・発行元:新潟医学会  

    CiNii Article

    CiNii Books

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    その他リンク: http://search.jamas.or.jp/link/ui/2016166686

  • 定圧炭酸ガス送気システムを用いた大腸内視鏡下腸管内送気圧と検査時の苦痛、最適な内視鏡視野との関連について

    高橋 祥史, 水野 研一, 小林 正明, 高橋 一也, 西垣 祐紀, 林 和直, 山本 幹, 本田 穣, 橋本 哲, 横山 純二, 竹内 学, 佐藤 祐一, 寺井 崇二

    Gastroenterological Endoscopy   57 ( Suppl.1 )   927 - 927   2015年4月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • Does an Endoscopic Submucosal Dissection Scar Affect Esophageal Motility?

    Kazuya Takahashi, Manabu Takeuchi, Yuichi Sato, Hiroki Sato, Kenichi Mizuno, Satoru Hashimoto, Shin-ryu Takeda, Masaaki Kobayashi, Shuji Terai

    GASTROENTEROLOGY   148 ( 4 )   S807 - S807   2015年4月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:W B SAUNDERS CO-ELSEVIER INC  

    Web of Science

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  • Endoscopic submucosal dissection for correct diagnosis of dysplasia in ulcerative colitis

    Ken Ichi Mizuno, Junji Yokoyama, Masaaki Kobayashi, Yoshifumi Takahashi, Kazuya Takahashi, Yuki Nishigaki, Takashi Yamamoto, Yutaka Honda, Satoru Hashimoto, Manabu Takeuchi, Yuichi Sato, Yoichi Ajioka

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   29   59 - 59   2014年11月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL  

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  • Long-term outcomes of endoscopic submucosal dissection for colorectal neoplasms

    Yoshifumi Takahashi, Ken Ichi Mizuno, Masaaki Kobayashi, Kazuya Takahashi, Yu Ki Nishigaki, Satoru Hashimoto, Manabu Takeuchi, Takashi Yamamoto, Honda Yutaka, Junji Yokoyama, Yu Ichi Sato

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   29   63 - 63   2014年11月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL  

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  • 原発巣の自然退縮後にリンパ節転移を来した肝細胞癌の一切除例

    荒生 祥尚, 高村 昌昭, 高橋 一也, 本田 博樹, 影向 一美, 橋本 哲, 佐藤 祐一, 野本 実, 坂田 純, 若井 俊文, 青柳 豊

    肝臓   55 ( Suppl.3 )   A868 - A868   2014年10月

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    記述言語:日本語   出版者・発行元:(一社)日本肝臓学会  

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▶ 全件表示

共同研究・競争的資金等の研究

  • 炎症性腸疾患患者に生じる粘膜治癒後の腹痛機序解析ーHPA axisの包括的評価ー

    研究課題/領域番号:22K16013

    2022年4月 - 2025年3月

    制度名:科学研究費助成事業

    研究種目:若手研究

    提供機関:日本学術振興会

    高橋 一也

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    配分額:4550000円 ( 直接経費:3500000円 、 間接経費:1050000円 )

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  • 食道アカラシアにおける食道細菌叢同定とCAGE法を用いた食道発癌リスク解析

    研究課題/領域番号:18K15776

    2018年4月 - 2021年3月

    制度名:科学研究費助成事業 若手研究

    研究種目:若手研究

    提供機関:日本学術振興会

    高橋 一也

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    配分額:3770000円 ( 直接経費:2900000円 、 間接経費:870000円 )

    経口内視鏡的筋層切開術(POEM)後には食道内でHoemophilusとNeisseriaの割合が有意に増加し、POEMの合併症である逆流性食道炎の関与が疑われた。しかしながら、POEM前後で食道内細菌叢の多様性に有意な変化はみられなかった。また食道内細菌叢と食道炎・食道扁平上皮癌発癌の関連は見いだせなかった。
    内視鏡的な炎症所見はPOEM後に有意に改善しており、食道細菌叢の異常以外の機序(例えば機械的な刺激など)が慢性的な食道炎と関与している可能性が示唆された。POEMによる炎症所見の改善は将来的な発癌予防につながる可能性があり、POEMは発癌予防の観点からも有効である可能性が示唆された。

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