Updated on 2026/09/13

写真a

 
SAKAI Akiko
 
Organization
Brain Research Institute Center for Bioresources Specially Appointed Assistant Professor
Title
Specially Appointed Assistant Professor
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Degree

  • 博士(理学) ( 2003.11   京都大学 )

  • 修士(理学) ( 1999.3   東京工業大学 )

Research Interests

  • 細胞質DNA

  • ミトコンドリア

  • genome-wide analysis

  • 加齢関連疾患

  • 臨界期

  • クロマチン

  • 染色体

  • 次世代シーケンサー

  • エピジェネティクス

  • 神経発達

Research Areas

  • Life Science / Molecular biology  / エピジェネティクス

  • Life Science / Genome biology

  • Life Science / Genetics

  • Life Science / Neuroscience-general

  • Life Science / Applied molecular and cellular biology

Research History (researchmap)

  • Niigata University   Specially Appointed Assistant Professor

    2021.4

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  • Niigata University   Graduate School of Medical and Dental Sciences

    2018.4 - 2021.3

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  • Niigata University   Graduate School of Medical and Dental Sciences

    2016.4 - 2018.3

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  • Niigata University   Graduate School of Medical and Dental Sciences

    2013.1 - 2016.3

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  • Niigata University   Graduate School of Medical and Dental Sciences   Specially Appointed Assistant Professor

    2011.3 - 2012.12

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  • Tokyo Institute of Technology   Graduate School of Bioscience and Biotechnology   Specially Appointed Assistant Professor

    2009.4 - 2011.3

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  • Tokyo Institute of Technology   Graduate School of Bioscience and Biotechnology

    2008.8 - 2009.3

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  • Harvard Medical School   Dept. of Biological Chemistry and Molecular Pharmacology

    2004.5 - 2008.7

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  • 京都大学 大学院生命理工学研究科   博士研究員

    2003.12 - 2004.4

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Research History

  • Niigata University   Center for Bioresources, Brain Research Institute   Specially Appointed Assistant Professor

    2021.4

Education

  • Kyoto University   理学研究科   生物科学専攻

    - 2003

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    Country: Japan

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  • Tokyo Institute of Technology   Bioscience and Biotechnology   バイオサイエンス専攻

    - 1999

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    Country: Japan

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  • International Christian University   College of Liberal Arts   Division of Natural Sciences

    - 1997

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    Country: Japan

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  • 神奈川県立多摩高校

    - 1993

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Professional Memberships

 

Papers

  • A protective role for APP in nuclear waste clearance via lysosomal exocytosis

    Godfried Dougnon, Takayoshi Otsuka, Yuka Nakamura, Akiko Sakai, Tomoyuki Yamanaka, Noriko Matsui, Asa Nakahara, Ai Ito, Atsushi Hatano, Masaki Matsumoto, Hironaka Igarashi, Akiyoshi Kakita, Masaki Ueno, Hideaki Matsui

    Proceedings of the National Academy of Sciences   2026.6

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.2524190123

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  • GPATCH4 contributes to nucleolus morphology and its dysfunction impairs cell viability

    Kazuki Kodera, Ryuichi Hishida, Akiko Sakai, Hiromi Nyuzuki, Noriko Matsui, Tomoyuki Yamanaka, Akihiko Saitoh, Hideaki Matsui

    Biochemical and Biophysical Research Communications   693   149384 - 149384   2024.1

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.bbrc.2023.149384

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  • Cellular response against cytosolic leakage of mitochondrial DNA: insights into the pathology of Parkinson's disease. Reviewed International journal

    Akiko Sakai, Hideaki Matsui

    Neural regeneration research   17 ( 12 )   2682 - 2684   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4103/1673-5374.335816

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  • PI4P/PS countertransport by ORP10 at ER–endosome membrane contact sites regulates endosome fission Reviewed International journal

    Asami Kawasaki, Akiko Sakai, Hiroki Nakanishi, Junya Hasegawa, Tomohiko Taguchi, Junko Sasaki, Hiroyuki Arai, Takehiko Sasaki, Michihiro Igarashi, Fubito Nakatsu

    Journal of Cell Biology   221 ( 1 )   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Rockefeller University Press  

    Membrane contact sites (MCSs) serve as a zone for nonvesicular lipid transport by oxysterol-binding protein (OSBP)-related proteins (ORPs). ORPs mediate lipid countertransport, in which two distinct lipids are transported counterdirectionally. How such lipid countertransport controls specific biological functions, however, remains elusive. We report that lipid countertransport by ORP10 at ER–endosome MCSs regulates retrograde membrane trafficking. ORP10, together with ORP9 and VAP, formed ER–endosome MCSs in a phosphatidylinositol 4-phosphate (PI4P)-dependent manner. ORP10 exhibited a lipid exchange activity toward its ligands, PI4P and phosphatidylserine (PS), between liposomes in vitro, and between the ER and endosomes in situ. Cell biological analysis demonstrated that ORP10 supplies a pool of PS from the ER, in exchange for PI4P, to endosomes where the PS-binding protein EHD1 is recruited to facilitate endosome fission. Our study highlights a novel lipid exchange at ER–endosome MCSs as a nonenzymatic PI4P-to-PS conversion mechanism that organizes membrane remodeling during retrograde membrane trafficking.

    DOI: 10.1083/jcb.202103141

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  • Glutamatergic pathways in the brains of turtles: A comparative perspective among reptiles, birds, and mammals. International journal

    Mohammad Tufazzal Hussan, Akiko Sakai, Hideaki Matsui

    Frontiers in neuroanatomy   16   937504 - 937504   2022

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    Language:English   Publishing type:Research paper (scientific journal)  

    Glutamate acts as the main excitatory neurotransmitter in the brain and plays a vital role in physiological and pathological neuronal functions. In mammals, glutamate can cause detrimental excitotoxic effects under anoxic conditions. In contrast, Trachemys scripta, a freshwater turtle, is one of the most anoxia-tolerant animals, being able to survive up to months without oxygen. Therefore, turtles have been investigated to assess the molecular mechanisms of neuroprotective strategies used by them in anoxic conditions, such as maintaining low levels of glutamate, increasing adenosine and GABA, upregulating heat shock proteins, and downregulating K ATP channels. These mechanisms of anoxia tolerance of the turtle brain may be applied to finding therapeutics for human glutamatergic neurological disorders such as brain injury or cerebral stroke due to ischemia. Despite the importance of glutamate as a neurotransmitter and of the turtle as an ideal research model, the glutamatergic circuits in the turtle brain remain less described whereas they have been well studied in mammalian and avian brains. In reptiles, particularly in the turtle brain, glutamatergic neurons have been identified by examining the expression of vesicular glutamate transporters (VGLUTs). In certain areas of the brain, some ionotropic glutamate receptors (GluRs) have been immunohistochemically studied, implying that there are glutamatergic target areas. Based on the expression patterns of these glutamate-related molecules and fiber connection data of the turtle brain that is available in the literature, many candidate glutamatergic circuits could be clarified, such as the olfactory circuit, hippocampal-septal pathway, corticostriatal pathway, visual pathway, auditory pathway, and granule cell-Purkinje cell pathway. This review summarizes the probable glutamatergic pathways and the distribution of glutamatergic neurons in the pallium of the turtle brain and compares them with those of avian and mammalian brains. The integrated knowledge of glutamatergic pathways serves as the fundamental basis for further functional studies in the turtle brain, which would provide insights on physiological and pathological mechanisms of glutamate regulation as well as neural circuits in different species.

    DOI: 10.3389/fnana.2022.937504

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  • Experience‐dependent transcriptional regulation in juvenile brain development Reviewed

    Akiko Sakai, Sayaka Sugiyama

    Development, Growth & Differentiation   60 ( 8 )   473 - 482   2018.10

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/dgd.12571

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  • Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex Reviewed

    Xubin Hou, Nozomu Yoshioka, Hiroaki Tsukano, Akiko Sakai, Shinji Miyata, Yumi Watanabe, Yuchio Yanagawa, Kenji Sakimura, Kosei Takeuchi, Hiroshi Kitagawa, Takao K. Hensch, Katsuei Shibuki, Michihiro Igarashi, Sayaka Sugiyama

    SCIENTIFIC REPORTS   7 ( 1 )   12646   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-04007-x

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  • Genome-Wide Target Analyses of Otx2 Homeoprotein in Postnatal Cortex Reviewed

    Akiko Sakai, Ryuichiro Nakato, Yiwei Ling, Xubin Hou, Norikazu Hara, Tomoya Iijima, Yuchio Yanagawa, Ryozo Kuwano, Shujiro Okuda, Katsuhiko Shirahige, Sayaka Sugiyama

    FRONTIERS IN NEUROSCIENCE   11   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fnins.2017.00307

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  • Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE Reviewed

    Sushmita Roy, Jason Ernst, Peter V. Kharchenko, Pouya Kheradpour, Nicolas Negre, Matthew L. Eaton, Jane M. Landolin, Christopher A. Bristow, Lijia Ma, Michael F. Lin, Stefan Washietl, Bradley I. Arshinoff, Ferhat Ay, Patrick E. Meyer, Nicolas Robine, Nicole L. Washington, Luisa Di Stefano, Eugene Berezikov, Christopher D. Brown, Rogerio Candeias, Joseph W. Carlson, Adrian Carr, Irwin Jungreis, Daniel Marbach, Rachel Sealfon, Michael Y. Tolstorukov, Sebastian Will, Artyom A. Alekseyenko, Carlo Artieri, Benjamin W. Booth, Angela N. Brooks, Qi Dai, Carrie A. Davis, Michael O. Duff, Xin Feng, Andrey A. Gorchakov, Tingting Gu, Jorja G. Henikoff, Philipp Kapranov, Renhua Li, Heather K. MacAlpine, John Malone, Aki Minoda, Jared Nordman, Katsutomo Okamura, Marc Perry, Sara K. Powell, Nicole C. Riddle, Akiko Sakai, Anastasia Samsonova, Jeremy E. Sandler, Yuri B. Schwartz, Noa Sher, Rebecca Spokony, David Sturgill, Marijke van Baren, Kenneth H. Wan, Li Yang, Charles Yu, Elise Feingold, Peter Good, Mark Guyer, Rebecca Lowdon, Kami Ahmad, Justen Andrews, Bonnie Berger, Steven E. Brenner, Michael R. Brent, Lucy Cherbas, Sarah C. R. Elgin, Thomas R. Gingeras, Robert Grossman, Roger A. Hoskins, Thomas C. Kaufman, William Kent, Mitzi I. Kuroda, Terry Orr-Weaver, Norbert Perrimon, Vincenzo Pirrotta, James W. Posakony, Bing Ren, Steven Russell, Peter Cherbas, Brenton R. Graveley, Suzanna Lewis, Gos Micklem, Brian Oliver, Peter J. Park, Susan E. Celniker, Steven Henikoff, Gary H. Karpen, Eric C. Lai, David M. MacAlpine, Lincoln D. Stein, Kevin P. White, Manolis Kellis

    SCIENCE   330 ( 6012 )   1787 - 1797   2010.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/science.1198374

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  • Transcriptional and Developmental Functions of the H3.3 Histone Variant in Drosophila Reviewed

    Akiko Sakai, Brian E. Schwartz, Sara Goldstein, Kami Ahmad

    CURRENT BIOLOGY   19 ( 21 )   1816 - 1820   2009.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cub.2009.09.021

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  • The XNP remodeler targets dynamic chromatin in Drosophila Reviewed

    Jonathan I. Schneiderman, Akiko Sakai, Sara Goldstein, Kami Ahmad

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   106 ( 34 )   14472 - 14477   2009.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.0905816106

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  • Genome-wide profiling of salt fractions maps physical properties of chromatin Reviewed

    Steven Henikoff, Jorja G. Henikoff, Akiko Sakai, Gabriel B. Loeb, Kami Ahmad

    GENOME RESEARCH   19 ( 3 )   460 - 469   2009.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1101/gr.087619.108

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  • Condensin but not cohesin SMC heterodimer induces DNA reannealing through protein-protein assembly Reviewed

    A Sakai, K Hizume, T Sutani, K Takeyasu, M Yanagida

    EMBO JOURNAL   22 ( 11 )   2764 - 2775   2003.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/emboj/cdg247

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  • Condensin architecture and interaction with DNA: Regulatory non-SMC subunits bind to the head of SMC heterodimer Reviewed

    SH Yoshimura, K Hizume, A Murakami, T Sutani, K Takeyasu, M Yanagida

    CURRENT BIOLOGY   12 ( 6 )   508 - 513   2002.3

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  • Characterization of fission yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase Reviewed

    T Tomonaga, K Nagao, Y Kawasaki, K Furuya, A Murakami, J Morishita, T Yuasa, T Sutani, SE Kearsey, F Uhlmann, K Nasmyth, M Yanagida

    GENES & DEVELOPMENT   14 ( 21 )   2757 - 2770   2000.11

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MISC

Awards

  • Short talk award

    2008.5   Japanese Society for Epigenetics   The H3.3 histone variant is required for transcription and nuclear organization

    SAKAI Akiko

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Research Projects

  • 老化・疾患をもたらす各種の細胞質DNAに対するセンサーと細胞応答の比較解析

    Grant number:24K08826

    2024.4 - 2027.3

    System name:科学研究費助成事業

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    酒井 晶子, 松井 秀彰

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

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  • 幼年期の脳発達を司る神経細胞種特異的な遺伝子発現調節:コヒーシンの役割

    Grant number:21K06389

    2021.4 - 2024.3

    System name:科学研究費助成事業 基盤研究(C)

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    酒井 晶子

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

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  • 経験による神経回路の発達機構をクロマチン動態から解明する

    2019.10

    System name:医学系研究助成

    Awarding organization:武田科学振興財団

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  • 臨界期可塑性におけるコヒーシンを介したクロマチン構造制御のメカニズム

    2018.4 - 2021.3

    System name:科学研究費補助金 基盤研究(C)

    酒井 晶子

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    Authorship:Principal investigator  Grant type:Competitive

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  • 経験依存的な神経回路可塑性をもたらすクロマチン構造変化の解析

    2018.4 - 2021.3

    System name:特別研究員奨励費

    Awarding organization:日本学術振興会

    酒井 晶子

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  • 発達期の脳の細胞種特異的クロマチン動態から解明する神経回路可塑性のメカニズム

    2016.4 - 2018.3

    System name:科学研究費補助金 挑戦的萌芽研究

    酒井 晶子

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    Authorship:Principal investigator  Grant type:Competitive

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  • 神経回路の可塑性を制御するクロマチン動態の解析

    2013.1 - 2016.3

    System name:特別研究員奨励費

    Awarding organization:日本学術振興会

    酒井晶子

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    Authorship:Principal investigator  Grant type:Competitive

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  • 細胞老化に伴うヘテロクロマチン領域形成のゲノム学的手法による機能解析

    2011.4 - 2013.3

    System name:科学研究費補助金 若手研究(B)

    酒井晶子

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    Authorship:Principal investigator  Grant type:Competitive

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Teaching Experience (researchmap)

Teaching Experience

  • 機能生理学

    2021
    Institution name:新潟大学

  • 機能生理学

    2021
    Institution name:新潟大学

 

Social Activities

  • 中高生サイエンス・セミナー

    Role(s): Lecturer

    新潟大学男女共同参画推進室  2019.1 - 2021.3

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