2025/10/19 更新

写真a

ミナト ケイタロウ
湊 圭太郎
MINATO Keitaro
所属
医歯学総合病院 整形外科 助教
職名
助教
外部リンク

経歴

  • 新潟大学   医歯学総合病院 整形外科   助教

    2022年4月 - 現在

 

論文

  • 間葉系間質細胞の病的・生理的機能の解明に向けて 種々の臓器における間葉系間質細胞の役割

    黒澤 珠希, 梶 典幸, 上住 円, 吉本 由紀, 湊 圭太郎, 長谷 栄治, 堀 正敏, 上住 聡芳

    日本生化学会大会プログラム・講演要旨集   96回   [2S10m - 01]   2023年10月

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    記述言語:日本語   出版者・発行元:(公社)日本生化学会  

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  • 複合現実(Mixed Reality,MR)ガイド下椎弓根スクリュー挿入の試み 側彎症モデルボーンを用いたPreliminary study

    大橋 正幸, 渡辺 慶, 田仕 英希, 牧野 達夫, 湊 圭太郎, 花房 繁寿, 川島 寛之

    東北整形災害外科学会雑誌   66 ( 1 )   221 - 222   2023年6月

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    記述言語:日本語   出版者・発行元:東北整形災害外科学会  

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  • 脊椎手術の低侵襲化と術中・術後の合併症予防 重度側彎症(≧50°)を伴う成人脊柱変形に対する脊椎矯正固定術の成績と問題点

    大橋 正幸, 渡辺 慶, 田仕 英希, 牧野 達夫, 湊 圭太郎, 田中 裕貴, 川島 寛之, 平野 徹

    東北整形災害外科学会雑誌   66 ( 1 )   132 - 133   2023年6月

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    記述言語:日本語   出版者・発行元:東北整形災害外科学会  

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  • 再発性脊髄髄膜種の手術成績と病理組織学的特徴の検討

    田中 裕貴, 大橋 正幸, 湊 圭太郎, 牧野 達夫, 田仕 英希, 渡辺 慶, 川島 寛之

    Journal of Spine Research   14 ( 3 )   452 - 452   2023年4月

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    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

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  • 椎間板ヘルニアを続発した小児頸椎椎間板石灰化症 症例報告とシステマティックレビュー

    吉田 侑真, 大橋 正幸, 渡辺 慶, 田仕 英希, 牧野 達夫, 湊 圭太郎, 川島 寛之

    Journal of Spine Research   14 ( 3 )   546 - 546   2023年4月

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    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

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  • 重度側彎症(≧50°)を伴う成人脊柱変形に対する脊椎矯正固定術の手術成績と問題点

    大橋 正幸, 渡辺 慶, 平野 徹, 田仕 英希, 牧野 達夫, 湊 圭太郎, 花房 繁寿, 川島 寛之

    Journal of Spine Research   14 ( 3 )   287 - 287   2023年4月

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    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

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  • 脊髄腫瘍摘出術における病理診断 術中迅速診断の有用性に注目して

    渡邊 慶, 大橋 正幸, 田仕 英希, 牧野 達夫, 湊 圭太郎, 田中 裕貴, 川島 寛之, 平野 徹

    Journal of Spine Research   14 ( 3 )   452 - 452   2023年4月

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    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

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  • 圧迫性頸髄症患者における歩行障害の特徴:重症度別の歩行解析

    牧野 達夫, 渡辺 慶, 溝内 龍樹, 浦川 貴朗, 大橋 正幸, 田仕 英希, 湊 圭太郎, 川島 寛之

    Journal of Spine Research   14 ( 3 )   220 - 220   2023年4月

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    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

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  • 術中の傍脊柱筋の解離で側彎はどの程度変化するか 胸腰椎側彎における調査

    湊 圭太郎, 花房 繁寿, 牧野 達夫, 田仕 英希, 大橋 正幸, 渡辺 慶, 川島 寛之

    Journal of Spine Research   14 ( 3 )   283 - 283   2023年4月

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    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

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  • 脊髄腫瘍摘出術における術中迅速診断の有用性と限界

    渡辺 慶, 平野 徹, 大橋 正幸, 田仕 英希, 牧野 達夫, 湊 圭太郎, 川島 寛之

    日本整形外科学会雑誌   97 ( 2 )   S283 - S283   2023年3月

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    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

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  • 思春期特発性胸椎側彎症に対する後方固定術後10年での頸部愁訴 臨床的意義と危険因子の検討

    大橋 正幸, 渡辺 慶, 平野 徹, 長谷川 和宏, 田仕 英希, 牧野 達夫, 湊 圭太郎, 川島 寛之

    日本整形外科学会雑誌   97 ( 3 )   S584 - S584   2023年3月

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    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

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  • Analyses of Mesenchymal Progenitors in Skeletal Muscle by Fluorescence-Activated Cell Sorting and Tissue Clearing. 国際誌

    Madoka Ikemoto-Uezumi, Tamaki Kurosawa, Keitaro Minato, Akiyoshi Uezumi

    Methods in molecular biology (Clifton, N.J.)   2640   117 - 127   2023年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Mesenchymal progenitors, which are resident progenitor populations residing in skeletal muscle interstitial space, contribute to pathogeneses such as fat infiltration, fibrosis, and heterotopic ossification. In addition to their pathological roles, mesenchymal progenitors have also been shown to play important roles for successful muscle regeneration and homeostatic muscle maintenance. Therefore, detailed and accurate analyses of these progenitors are essential for the research on muscle diseases and health. Here, we describe a method for purification of mesenchymal progenitors based on the expression of PDGFRα, which is a specific and well-established marker for mesenchymal progenitors, using fluorescence-activated cell sorting (FACS). Purified cells can be used in several downstream experiments including cell culture, cell transplantation, and gene expression analysis. We also describe the method for whole-mount 3-dimensional imaging of mesenchymal progenitors by utilizing tissue clearing. The methods described herein provide a powerful platform for studying mesenchymal progenitors in skeletal muscle.

    DOI: 10.1007/978-1-0716-3036-5_9

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  • 小児頸椎椎間板石灰化症の1例

    吉田 侑真, 大橋 正幸, 渡邊 慶, 田仕 英希, 牧野 達夫, 湊 圭太郎, 川島 寛之

    新潟整形外科研究会会誌   38 ( 1 )   81 - 81   2022年12月

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    記述言語:日本語   出版者・発行元:新潟整形外科研究会  

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  • 複合現実(Mixed Reality,MR)を併用した椎弓根スクリュー挿入の試み 側彎症モデルボーンを用いたPreliminary study

    大橋 正幸, 渡邊 慶, 田仕 英希, 牧野 達夫, 湊 圭太郎, 花房 繁寿, 川島 寛之

    新潟整形外科研究会会誌   38 ( 1 )   88 - 88   2022年12月

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    記述言語:日本語   出版者・発行元:新潟整形外科研究会  

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  • 肥厚性硬膜炎による対麻痺に対して手術加療を要した一例

    湊 圭太郎, 花房 繁寿, 牧野 達夫, 田仕 英希, 大橋 正幸, 渡邊 慶, 川島 寛之

    新潟整形外科研究会会誌   38 ( 1 )   89 - 89   2022年12月

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    記述言語:日本語   出版者・発行元:新潟整形外科研究会  

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  • 若齢マウスと老齢マウスの長趾伸筋を用いた側方力伝達測定による筋間質の機能評価

    湊 圭太郎, 吉本 由紀, 渡辺 慶, 川島 寛之, 上住 聡芳

    日本整形外科学会雑誌   96 ( 8 )   S1679 - S1679   2022年9月

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    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

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  • 運動依存性の筋線維由来マイオカインの同定と機能解析によるサルコペニア治療へのアプローチ

    湊 圭太郎, 黒澤 珠希, 吉本 由紀, 豊田 雅士, 東 浩太郎, 井上 聡, 細山 徹, 渡辺 慶, 川島 寛之, 大野 欽司, 上住 聡芳

    日本整形外科学会雑誌   96 ( 8 )   S1618 - S1618   2022年9月

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    記述言語:日本語   出版者・発行元:(公社)日本整形外科学会  

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  • PDGFRα陽性間質細胞の筋特異性から探るサルコペニアのメカニズム

    黒澤 珠希, 梶 典幸, 上住 円, 吉本 由紀, 湊 圭太郎, 長谷 栄治, 堀 正敏, 上住 聡芳

    日本筋学会学術集会プログラム・抄録集   8回   126 - 126   2022年8月

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    記述言語:日本語   出版者・発行元:(一社)日本筋学会  

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  • 胸椎を主カーブとする思春期特発性側彎症に対する後方矯正固定術後10年での健康関連QOL評価 非手術例および健常者との比較

    大橋 正幸, 渡辺 慶, 平野 徹, 長谷川 和宏, 田仕 英希, 湊 圭太郎, 牧野 達夫, 田中 裕貴, 川島 寛之

    Journal of Spine Research   13 ( 3 )   377 - 377   2022年3月

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    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

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  • 圧迫性頸髄症患者の術前後における歩行解析と患者立脚型評価JOACMEQとの相関

    牧野 達夫, 渡辺 慶, 溝内 龍樹, 浦川 貴朗, 大橋 正幸, 田仕 英希, 湊 圭太郎, 田中 裕貴, 川島 寛之

    Journal of Spine Research   13 ( 3 )   581 - 581   2022年3月

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    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

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  • 成人脊柱変形矯正手術後に歩行機能を獲得できる患者特性の検討

    渡辺 慶, 大橋 正幸, 田仕 英希, 牧野 達夫, 湊 圭太郎, 田中 裕貴, 川島 寛之, 平野 徹, 大矢 渉, 長谷川 和宏

    Journal of Spine Research   13 ( 3 )   238 - 238   2022年3月

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    記述言語:日本語   出版者・発行元:(一社)日本脊椎脊髄病学会  

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  • Measurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice. 国際誌

    Keitaro Minato, Yuki Yoshimoto, Tamaki Kurosawa, Kei Watanabe, Hiroyuki Kawashima, Madoka Ikemoto-Uezumi, Akiyoshi Uezumi

    International journal of molecular sciences   22 ( 22 )   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The main function of skeletal muscles is to generate force. The force developed by myofiber contraction is transmitted to the tendon. There are two pathways of force transmission from myofibers to tendons: longitudinal transmission that depends on tension elicited via the myotendinous junction and lateral transmission that depends on shear elicited via the interface between the myofiber surface and surrounding connective tissue. Experiments using animal muscle and mathematical models indicated that lateral transmission is the dominant pathway in muscle force transmission. Studies using rat muscle showed that the efficiency of lateral force transmission declines with age. Here, the lateral transmission of force was measured using the extensor digitorum longus muscle from young and old mice. Dependence on longitudinal transmission increased in the old muscle, and there was a trend for lower efficiency of lateral force transmission in the old muscle compared to the young muscle. There was a noticeable increase in the connective tissue volume in the old muscle; however, there was no significant change in the expression of dystrophin, a critical molecule for the link between the myofiber cytoskeleton and extracellular matrix. This study demonstrates the measurement of lateral force transmission in mouse muscles and that alteration in force transmission property may underlie age-related muscle weakness.

    DOI: 10.3390/ijms222212356

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  • Indication for drainage for a hematogenous iliopsoas abscess: Analysis of patients initially treated without drainage.

    Hirokazu Shoji, Masayuki Ohashi, Yoichi Yajiri, Keitaro Minato, Mio Yahata, Masashi Wakasugi, Kimihiko Sawakami, Kei Watanabe

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association   26 ( 6 )   1130 - 1134   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: This study aimed to determine the indications for drainage in extended haematogenous iliopsoas abscesses (IPAs), which include both primary and vertebral osteomyelitis-related IPAs. METHODS: Sixty-three IPA patients who were initially treated with only antibiotics and no drainage were enrolled. The success (S) group included patients who were cured without drainage, while the failure (F) group included those who required open or percutaneous drainage or died. RESULTS: Compared with patients in the S group, patients in the F group (n = 15) had a higher incidence of end-stage renal disease on hemodialysis, compromised immunity, vertebral osteomyelitis of the cervicothoracic spine, other musculoskeletal infections, and multilocular abscesses. The IPAs in the F group had larger transverse and longitudinal diameters. In receiver operating characteristic curve analyses for the diameter of IPAs, the most valuable cut-off points predicting the F group were a longitudinal diameter of 5.0 cm (sensitivity, 1.0; specificity, 0.67) and a transverse diameter of 2.3 cm (sensitivity, 0.73; specificity, 0.73). A combination of both diameter cut-offs had high specificity (sensitivity, 0.73; specificity, 0.90). CONCLUSIONS: Drainage should be applied in case of a larger abscess with transverse diameter ≥ 2.3 cm and longitudinal diameter ≥ 5.0 cm. Conversely, IPAs with longitudinal diameter <5 cm do not require drainage. Haemodialysis, compromised immunity, vertebral osteomyelitis of the cervicothoracic spine, and musculoskeletal infections are risk factors of conservative treatment failure.

    DOI: 10.1016/j.jos.2020.10.023

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  • 様々な臓器に存在するPDGFRα陽性間質細胞の比較解析

    黒澤 珠希, 梶 典幸, 上住 円, 周 赫英, 吉本 由紀, 湊 圭太郎, 堀 正敏, 上住 聡芳

    日本筋学会学術集会プログラム・抄録集   7回   85 - 85   2021年11月

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    記述言語:日本語   出版者・発行元:(一社)日本筋学会  

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  • Transgenic Expression of Bmp3b in Mesenchymal Progenitors Mitigates Age-Related Muscle Mass Loss and Neuromuscular Junction Degeneration. 国際誌

    Tamaki Kurosawa, Keitaro Minato, Madoka Ikemoto-Uezumi, Jun Hino, Kunihiro Tsuchida, Akiyoshi Uezumi

    International journal of molecular sciences   22 ( 19 )   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Skeletal muscle is a vital organ for a healthy life, but its mass and function decline with aging, resulting in a condition termed sarcopenia. The etiology of sarcopenia remains unclear. We recently demonstrated that interstitial mesenchymal progenitors are essential for homeostatic muscle maintenance, and a diminished expression of the mesenchymal-specific gene Bmp3b is associated with sarcopenia. Here, we assessed the protective function of Bmp3b against sarcopenia by generating conditional transgenic (Tg) mice that enable a forced expression of Bmp3b specifically in mesenchymal progenitors. The mice were grown until they reached the geriatric stage, and the age-related muscle phenotypes were examined. The Tg mice had significantly heavier muscles compared to control mice, and the type IIB myofiber cross-sectional areas were preserved in Tg mice. The composition of the myofiber types did not differ between the genotypes. The Tg mice showed a decreasing trend of fibrosis, but the degree of fat infiltration was as low as that in the control mice. Finally, we observed the preservation of innervated neuromuscular junctions (NMJs) in the Tg muscle in contrast to the control muscle, where the NMJ degeneration was conspicuous. Thus, our results indicate that the transgenic expression of Bmp3b in mesenchymal progenitors alleviates age-related muscle deterioration. Collectively, this study strengthens the beneficial role of mesenchymal Bmp3b against sarcopenia and suggests that preserving the youthfulness of mesenchymal progenitors may be an effective means of combating sarcopenia.

    DOI: 10.3390/ijms221910246

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  • Minimally Invasive Spinal Stabilization with Denosumab before Total Spondylectomy for a Collapsing Lower Lumbar Spinal Giant Cell Tumor.

    Keitaro Minato, Toru Hirano, Hiroyuki Kawashima, Tetsuro Yamagishi, Kei Watanabe, Masayuki Ohashi, Akira Ogose, Naoto Endo

    Acta medica Okayama   75 ( 1 )   95 - 101   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A 21-year-old man consulted our hospital for treatment of a spinal giant cell tumor (GCT) of Enneking stage III. Lower lumbar-spine tumors and severe spinal canal stenosis are associated with high risk for surgical mor-bidity. Stability was temporarily secured with a percutaneous pedicle screw fixation in combination with deno-sumab, which shrank the tumor. Total en bloc spondylectomy was then performed 6 months after initiation of denosumab, and the patient was followed for 3 years. There was no local recurrence, and bony fusion was obtained. Minimally invasive surgery and denosumab allowed safer and easier treatment of a collapsing lower lumbar extra-compartmental GCT.

    DOI: 10.18926/AMO/61442

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  • Rib Hyperostosis as a Risk Factor for Poor Prognosis in Cervical Spine Injury Patients With Diffuse Idiopathic Skeletal Hyperostosis. 国際誌

    Kimihiko Sawakami, Kei Watanabe, Tsuyoshi Sato, Kazuto Miura, Keiichi Katsumi, Noboru Hosaka, Shinsen Nomura, Ryuta Fujikawa, Ren Kikuchi, Hideki Tashi, Keitaro Minato, Hiroyuki Segawa, Takui Ito, Seiichi Ishikawa, Toru Hirano, Naoto Endo

    Spine   45 ( 5 )   300 - 308   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    STUDY DESIGN: Retrospective multi-center study. OBJECTIVE: To identify the morphological features of costovertebral joints and ribs in surgically managed cervical injury patients with diffuse idiopathic skeletal hyperostosis (DISH) and to examine its impact on their vital prognosis. SUMMARY OF BACKGROUND DATA: Several reports have indicated that DISH is an independent risk factor for mortality after spinal fracture. The reason for the high mortality in cervical injury patients with DISH is unclear, although some reports have suggested a possible association between pulmonary complications and mortality. METHODS: From 1999 to 2017, a total of 50 DISH patients (44 males) with cervical spine injuries who underwent spinal surgery were enrolled (average age 74 yrs). Prognosis and clinical risk factor data were collected; the morphological features of the patients' costovertebral joints and ribs were evaluated with computed tomography. The influence of each proposed risk factor and thoracic morphological feature on mortality was tested with univariate and multivariate analyses. RESULTS: The survival rate at 5 years after surgery was 52.3%. Nineteen (38%) patients died, and the most common cause of death was pneumonia (68%). Costovertebral bone excrescences and rib hyperostosis were found to be thoracic pathognomonic signs; their frequencies were 94% and 82%, respectively, and these conditions occurred in an average of 7.0 joints and 4.7 bones, respectively. The results of the log-rank test showed a significant difference in age, injury severity score (ISS), costovertebral bone excrescences, and rib hyperostosis. The results of age-adjusted multivariate analysis indicated that age (hazard ratio [HR] = 8.65, 95% confidence interval [CI] = 1.10-68.28, P = 0.041) and rib hyperostosis (HR = 3.82, 95% CI = 1.38-10.57, P = 0.010) were associated with mortality. CONCLUSION: Reduced chest wall mobility associated with rib hyperostosis in cervical spine injury patients with DISH leads to a poor prognosis. LEVEL OF EVIDENCE: 3.

    DOI: 10.1097/BRS.0000000000003252

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  • Health-Related Quality of Life in Nonoperated Patients With Adolescent Idiopathic Scoliosis in the Middle Years: A Mean 25-Year Follow-up Study. 国際誌

    Kei Watanabe, Masayuki Ohashi, Toru Hirano, Keiichi Katsumi, Tatsuki Mizouchi, Hideki Tashi, Keitaro Minato, Kazuhiro Hasegawa, Naoto Endo

    Spine   45 ( 2 )   E83-E89   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    STUDY DESIGN: A retrospective long-term follow-up study. OBJECTIVE: To investigate the health-related quality of life (HRQOL) status in middle-aged patients with adolescent idiopathic scoliosis (AIS) treated non-surgically. SUMMARY OF BACKGROUND DATA: The HRQOL status using various established questionnaires for non-operated AIS patients has not been fully investigated in long-term follow-up surveys. METHODS: Inclusion criteria were non-surgical treatment for AIS, more than or equl to 30° major scoliosis at skeletal maturity (Risser grade ≥4), and age more than or equl to 30 years at the time of the survey. A total of 107 AIS patients were included and divided into three groups (single main thoracic [MT] curve group; n = 50, single thoracolumbar/lumbar [TL/L] curve group; n = 19, and double-major [DM] curve group; n = 38) based on curve location at skeletal maturity. Age- and sex-matched volunteers were selected as the control group. RESULTS: There were no significant differences in age at survey, body mass index, bone mineral density of the femoral neck, and skeletal muscle mass index among the groups. In all groups, major scoliosis progressed by approximately 0.5°/yr from the time of skeletal maturity to the survey. The thoracolumbar (TL/L) and double-major (DM) groups showed significantly worse visual analog scale scores for low back pain compared with the main thoracice (MT) group (P < 0.05). The all-scoliosis groups showed significantly worse scores for self-image domain of the Scoliosis Research Society Outcome Instrument-22 (SRS-22) than the control group (P < 0.0001). The TL/L group showed significantly worse scores for walking ability and social function domains of the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) (P < 0.05). There were no significant differences in Oswestory Disability Index and Short-Form-12 among the four groups. CONCLUSION: AIS patients with single MT curve maintain equal HRQOL status compared with healthy controls. Patients with structural TL/L curves are likely to experience greater annual TL/L curve progression and have substantial low back pain or worse low back pain-specific HRQOL status during middle age. LEVEL OF EVIDENCE: 4.

    DOI: 10.1097/BRS.0000000000003216

    PubMed

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