Faculty Profiles - YAMAGISHI Takuma

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YAMAGISHI Takuma

Organization

University Medical and Dental Hospital Neurology Assistant Professor

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Research History (researchmap)

Niigata University Medical and Dental Hospital Neurology Assistant Professor

2022.4

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Research History

Niigata University University Medical and Dental Hospital Assistant Professor

2022.4

Education

Niigata University Faculty of Medicine School of Medicine

2009.4 - 2015.3

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Papers

The Multifaceted Regulation of TDP-43 Condensates at the Intersection of Physiology and Pathology: Implications for Neurodegenerative Diseases

Akihiro Sugai, Takuma Yamagishi, Shingo Koide, Osamu Onodera

Phase Separation in Living Cells 253 - 270 2023.9

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Publishing type：Part of collection (book) Publisher：Springer Nature Singapore

DOI： 10.1007/978-981-99-4886-4_13

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Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex Reviewed International journal

Yuka Koike, Akihiro Sugai, Norikazu Hara, Junko Ito, Akio Yokoseki, Tomohiko Ishihara, Takuma Yamagishi, Shintaro Tsuboguchi, Mari Tada, Takeshi Ikeuchi, Akiyoshi Kakita, Osamu Onodera

Communications Biology 4 ( 1 ) 1107 - 1107 2021.12

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Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

In amyotrophic lateral sclerosis (ALS), TAR DNA-binding protein 43 (TDP-43), which is encoded by TARDBP, forms aggregates in the motor cortex. This aggregate formation may be triggered by an increase in the TDP-43 level with aging. However, the amount of TDP-43 is autoregulated by alternative splicing of the TARDBP 3′UTR, and how this autoregulation is affected by aging remains to be elucidated. We found that DNA demethylation in the autoregulatory region in the TARDBP 3′UTR reduced alternative splicing and increased TARDBP mRNA expression. Furthermore, in the human motor cortex, we found that this region was demethylated with aging, resulting in increased expression of TARDBP mRNA. The acceleration of DNA demethylation in the motor cortex was associated with the age of ALS onset. In summary, the dysregulation of TDP-43 autoregulation by age-related DNA demethylation in the motor cortex may explain the contribution of aging and motor system selectivity in ALS.

DOI： 10.1038/s42003-021-02621-0

PubMed

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Other Link： https://www.nature.com/articles/s42003-021-02621-0
Role of RNF213 p.4810K variant in the development of intracranial arterial disease in patients treated with nilotinib Reviewed

Masahiro Uemura, Masato Kanazawa, Takuma Yamagishi, Takahiro Nagai, Mami Takahashi, Shingo Koide, Masayoshi Tada, Junsuke Shimbo, Aiko Isami, Kunihiko Makino, Masayoshi Masuko, Kouji Nikkuni, Kouichirou Okamoto, Shuichi Igarashi, Kenichi Morita, Osamu Onodera

Journal of the Neurological Sciences 408 116577 - 116577 2020.1

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Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

DOI： 10.1016/j.jns.2019.116577

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Amyloid β-related angiitis presenting extensive brain involvement without detection of hemorrhagic lesions: A case report Reviewed

Yuya Hatano, Akihiro Sugai, Takuma Yamagishi, Akihiro Nakajima, Akiyoshi Kakita, Osamu Onodera

Rinsho Shinkeigaku 60 ( 3 ) 187 - 192 2020

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Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Societas Neurologica Japonica

DOI： 10.5692/clinicalneurol.cn-001340

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A case of anti-SRY-Related HMG-Box Gene 1 (SOX1) antibody-positive chorea Reviewed

Takuma Yamagishi, Kana Inoue, Haruka Ouchi, Ken Shibano, Kenju Hara

Rinsho Shinkeigaku 60 ( 12 ) 852 - 856 2020

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Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Societas Neurologica Japonica

DOI： 10.5692/clinicalneurol.cn-001454

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Post-traumatic thrombotic microangiopathy following pelvic fracture treated with transcatheter arterial embolization: a case report Reviewed

Kaori Ikegami, Takuma Yamagishi, Junya Tajima, Yukinori Inoue, Ken Kumagai, Yasuo Hirose, Daisuke Kondo, Koji Nikkuni

Journal of Medical Case Reports 12 ( 1 ) 2018.12

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Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

DOI： 10.1186/s13256-018-1757-1

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Other Link： http://link.springer.com/article/10.1186/s13256-018-1757-1/fulltext.html

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Books

相分離生物学の全貌

白木賢太郎（ Role： Contributor , 相分離メガネをかけて見直す神経変性疾患）

東京化学同人 2020.11 （ ISBN:9784807913466 ）

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Total pages：xi, 402p Language：Japanese

CiNii Books

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MISC

神経疾患を克服する-わが国の戦略(1)C.各論：神経疾患研究の現状の課題と展望(1)神経変性疾患

山岸拓磨, 須貝章弘, 小野寺理

CLINICAL NEUROSCIENCE(月刊臨床神経科学) 39 ( 9 ) 1163 - 1167 2021.9

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Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

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加齢と関連したDNA脱メチル化がTDP-43量の自己調節機構を障害する

小池佑佳, 須貝章弘, 原範和, 伊藤絢子, 横関明男, 石原智彦, 山岸拓磨, 坪口晋太朗, 他田真理, 池内健, 柿田明美, 小野寺理

Dementia Japan 35 ( 4 ) 2021

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J-GLOBAL

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The elimination systems of the brain, and diseases caused by its failure

270 ( 13 ) 1183 - 1187 2019.9

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Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

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アナグレリドの内服中止後、多発する時相の異なる脳梗塞を認めた本態性血小板血症を有する44歳女性例

浦部陽香, 畠山公大, 堅田慎一, 小野寺理, 山岸拓磨, 徳武孝允

神経治療学 35 ( 6 ) S237 - S237 2018.11

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Language：Japanese Publisher：(一社)日本神経治療学会

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