Updated on 2024/07/16

写真a

 
DOUGNON TCHETONNOUGBO GODFRIED
 
Organization
Brain Research Institute Center for Bioresources Assistant Professor
Title
Assistant Professor
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Degree

  • PhD ( 2022.3   Kyoto University )

Research Interests

  • Medicinal plants

  • Neuroscience

  • Attention-Deficit/Hyperactivity Disorder

  • Autism Spectrum Disorders

  • Zebrafish

  • Pharmacognosy

  • Aging

Research Areas

  • Life Science / Pharmaceutical chemistry and drug development sciences

  • Life Science / Pharmacology

  • Life Science / Neuroscience-general

  • Life Science / Animal physiological chemistry, physiology and behavioral biology

  • Life Science / Molecular biology

Research History (researchmap)

  • Niigata University   Brain Research Institute   Assistant Professor

    2022.4

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    Country:Japan

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  • Kyoto University   Graduate School of Pharmaceutical Sciences   Graduate Student (MEXT Government Scholarship)

    2017.4 - 2022.3

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    Country:Japan

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  • Kyoto University   Graduate School of Pharmaceutical Sciences   Research student (MEXT Government Scholarship)

    2016.4 - 2017.3

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    Country:Japan

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  • University of Abomey-Calavi   School of Pharmacy

    2012.10 - 2016.2

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    Country:Benin

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Research History

  • Niigata University   Center for Bioresources, Brain Research Institute   Assistant Professor

    2022.4

Education

  • Kyoto University/Graduate School of Pharmaceutical Sciences   PhD

    2019.4 - 2022.3

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    Country: Japan

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  • Kyoto University/Graduate School of Pharmaceutical Sciences   Master Degree

    2017.4 - 2019.3

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    Country: Japan

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  • Kyoto University/Graduate School of Pharmaceutical Sciences   Research Student

    2016.4 - 2017.3

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    Country: Japan

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  • University of Abomey-Calavi   Institute of Applied Biomedical Sciences

    2013.12 - 2016.2

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    Country: Benin

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  • University of Abomey-Calavi/Faculty of Health Sciences   School of Pharmacy   Pharmaceutical Doctor (PharmD)

    2008.10 - 2013.12

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    Country: Benin

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Professional Memberships

  • The Pharmaceutical Society of Japan

    2020

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  • Japanese Society of Pharmacognosy

    2018

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Qualification acquired

  • Pharmacist

 

Papers

  • Extracellular disposal of nuclear waste by APP: a protective mechanism impaired in Alzheimer’s disease

    Godfried Dougnon, Takayoshi Otsuka, Yuka Nakamura, Akiko Sakai, Tomoyuki Yamanaka, Noriko Matsui, Asa Nakahara, Ai Ito, Atsushi Hatano, Masaki Matsumoto, Hironaka Igarashi, Akiyoshi Kakita, Masaki Ueno, Hideaki Matsui

    2024.2

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    Publisher:Cold Spring Harbor Laboratory  

    Abstract

    Although the amyloid beta (Aβ) hypothesis<sup>1</sup>has long been central to Alzheimer’s disease (AD) research, effective therapeutic strategies remain elusive<sup>2,3</sup>. Here we re-evaluate the functions of amyloid precursor protein (APP) and reveal its critical function in protecting against nuclear impairment-induced cell death and inflammation<sup>4,5</sup>. Overexpression of APP mitigated etoposide or lamin A knockdown-induced nuclear damage, while APP removal or mutations exacerbated these effects. Interestingly, neurons differentiated from induced pluripotent stem cells (iPSCs) exhibited similar patterns, and notably, familial AD-associated mutant APP failed to confer protection against nuclear impairment. We identify APP’s interaction with a cytoplasmic structure of nuclear origin, termed “nuclear waste”, and propose its role in extracellular waste disposal. Intriguingly, cells lacking APP showed impaired nuclear waste clearance, leading to abnormal cytoplasmic accumulation of the nuclear waste. Similarly, neuron-specific APP overexpression using adeno-associated virus (AAV) in mice reduced neuronal death and inflammation caused by nuclear damage. Conversely, shRNA-mediated APP exacerbated these effects, and mutant APP associated with familial AD lacked protective effects. Moreover, postmortem analysis of AD brains revealed accumulation of abnormal nuclear waste in the neurocytoplasm, irregular nuclear morphology, and reduced APP levels per neuron. Our data underscore APP’s crucial role in disposing of nuclear waste, maintaining cellular homeostasis, and suggest its dysregulation as a potential contributor to AD pathogenesis. Restoring APP waste clearance in AD could be a promising target for disease-modifying therapies.

    DOI: 10.1101/2024.02.10.579739

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  • Local knowledge, practices, challenges of ethnopharmacologically used medicinal plants in Benin and implications for brain illnesses

    Godfried Dougnon, Victorien Tamègnon Dougnon, Jean Robert Klotoé, Eric Agbodjento, Dannialou Zoumarou, Boris Lègba, Hornel Koudokpon, Phénix Assogba, Leena Hanski, Eléonore Yayi Ladékan

    Scientific Reports   13 ( 1 )   2023.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media {LLC}  

    <jats:title>Abstract</jats:title><jats:p>Traditional medicine (TM) is a significant resource for primary healthcare management all over the world, and principally in Africa. Quality improvement activities that promote evidence-based practices and the integration of traditional medicine into primary healthcare systems can help improve the quality of patient care. In the Republic of Benin (West Africa), traditional medicine practitioners (TMPs) provide different treatments and ways of use, depending on the ailments and the medicinal plants used. The present study aimed at documenting the knowledge, attitudes and practices of Beninese TMPs regarding the use of medicinal plants and the challenges associated with their activities. A focus group survey was conducted using semi-structured interviews with a sample of 91 TMPs in 8 departments of the Republic of Benin. The respondents had an average age of 50 years old and belonged to various categories of TMPs. Medicinal plants are harvested depending on the season and time of the day, and are dried in the shade before being used as decoctions or infusions. Nevertheless, the majority of TMPs do not conduct the necessary tests for quality control, efficacy or toxicity of the proposed remedies, which raises several scientific interrogations, particularly for the treatment of mental and brain-related disorders. Among ~ 110 plants used in the treatment of several pathologies, 66 were revealed as threatened species. The challenges faced by TMPs are mainly material, financial and technical difficulties. The present study reports the importance of intervention to modernize TM practices in Benin. Quality improvement could enhance healthcare delivery and provide support for evidence-based interventions aimed at addressing behavioral, social, and environmental determinants of health.</jats:p>

    DOI: 10.1038/s41598-023-46647-2

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  • Modelling Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) Using Mice and Zebrafish

    Godfried Dougnon, Hideaki Matsui

    International Journal of Molecular Sciences   23 ( 14 )   7550 - 7550   2022.7

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    Publishing type:Research paper (scientific journal)   Publisher:MDPI AG  

    Autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) are two debilitating neurodevelopmental disorders. The former is associated with social impairments whereas the latter is associated with inattentiveness, hyperactivity, and impulsivity. There is recent evidence that both disorders are somehow related and that genes may play a large role in these disorders. Despite mounting human and animal research, the neurological pathways underlying ASD and ADHD are still not well understood. Scientists investigate neurodevelopmental disorders by using animal models that have high similarities in genetics and behaviours with humans. Mice have been utilized in neuroscience research as an excellent animal model for a long time; however, the zebrafish has attracted much attention recently, with an increasingly large number of studies using this model. In this review, we first discuss ASD and ADHD aetiology from a general point of view to their characteristics and treatments. We also compare mice and zebrafish for their similarities and discuss their advantages and limitations in neuroscience. Finally, we summarize the most recent and existing research on zebrafish and mouse models of ASD and ADHD. We believe that this review will serve as a unique document providing interesting information to date about these models, thus facilitating research on ASD and ADHD.

    DOI: 10.3390/ijms23147550

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  • Molecular Descriptors and QSAR Models for Sedative Activity of Sesquiterpenes Administered to Mice via Inhalation

    Godfried Dougnon, Michiho Ito

    Planta Medica   2022.2

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    Publishing type:Research paper (scientific journal)   Publisher:Georg Thieme Verlag {KG}  

    DOI: 10.1055/a-1770-7581

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  • Essential oils from Melia azedarach L. (Meliaceae) leaves: chemical variability upon environmental factors

    Godfried Dougnon, Michiho Ito

    Journal of Natural Medicines   2022.1

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11418-021-01579-x

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  • Essential Oil from the Leaves of Chromolaena odorata, and Sesquiterpene Caryophyllene Oxide Induce Sedative Activity in Mice

    Godfried Dougnon, Michiho Ito

    Pharmaceuticals   14 ( 7 )   651 - 651   2021.7

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    Publishing type:Research paper (scientific journal)   Publisher:{MDPI} {AG}  

    DOI: 10.3390/ph14070651

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  • Role of Ascaridole and p-Cymene in the Sleep-Promoting Effects of Dysphania ambrosioides Essential Oil via the GABAergic System in a ddY Mouse Inhalation Model

    Godfried Dougnon, Michiho Ito

    Journal of Natural Products   84 ( 1 )   91 - 100   2021.1

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    DOI: 10.1021/acs.jnatprod.0c01137

    Web of Science

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  • Inhalation Administration of the Bicyclic Ethers 1,8- and 1,4-cineole Prevent Anxiety and Depressive-Like Behaviours in Mice

    Godfried Dougnon, Michiho Ito

    Molecules   25 ( 8 )   1884 - 1884   2020.4

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    Publishing type:Research paper (scientific journal)   Publisher:{MDPI} {AG}  

    DOI: 10.3390/molecules25081884

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  • Sedative effects of the essential oil from the leaves of Lantana camara occurring in the Republic of Benin via inhalation in mice

    Dougnon, G., Ito, M.

    Journal of Natural Medicines   74 ( 1 )   2020

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11418-019-01358-9

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  • Medicinal uses, thin-layer chromatography and high-performance liquid chromatography profiles of plant species from Abomey-Calavi and Dantokpa Market in the Republic of Benin

    Godfried Dougnon, Michiho Ito

    Journal of Natural Medicines   74 ( 1 )   2019.7

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media {LLC}  

    DOI: 10.1007/s11418-019-01344-1

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  • Antihypertensive effect of extracts from <i>Crateva adansonii</i> DC.ssp. <i>adansonii</i> in the Wistar rats

    Marius Adjagba, Bonaventure Awede, Razack Osseni, Cyriaque Hountondji, Godfried Dougnon, Latifou Lagnika, Raphaël Darboux, Anatole Laleye

    International Journal of Biological and Chemical Sciences   11 ( 6 )   2604 - 2604   2018.4

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    Publishing type:Research paper (scientific journal)   Publisher:African Journals Online ({AJOL})  

    DOI: 10.4314/ijbcs.v11i6.5

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  • ETUDES ETHNOBOTANIQUE ET ETHNOPHARMACOLOGIQUE DES PLANTES UTILISEES DANS LE TRAITEMENT TRADITIONNEL DE L’HYPERTENSION ARTERIELLE AU CENTRE-BENIN

    Godfried DOUGNON

    2013

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    Language:English   Publishing type:Doctoral thesis  

    DOI: 10.13140/rg.2.2.14520.19202/1

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  • Phytochemical Screening, Nutritional and Toxicological Analyses of Leaves and Fruits of Solanum macrocarpon Linn (Solanaceae) in Cotonou (Benin)

    Godfried DOUGNON

    Food and Nutrition Sciences   2012

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.4236/fns.2012.311208

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Presentations

  • Molecular descriptors and QSAR models for sedative activity of sesquiterpenes compounds via inhalation administration to mice

    Godfried Dougnon

    The 142nd Annual Meeting of the Pharmaceutical Society of Japan  2022 

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    Presentation type:Poster presentation  

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  • Evaluation of sedative activity of essential oil of Dysphania ambrosioides by inhalation experiment using mice

    Godfried Dougnon

    The 141st Annual Meeting of the Pharmaceutical Society of Japan  2021 

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    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Sedative activity of Dysphania ambrosioides essential oil via inhalation administration in mice

    Godfried Dougnon

    The 2nd Pharmaceutical Research Exchange Salon  2021 

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    Language:English   Presentation type:Poster presentation  

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  • Anxiolytic and antidepressant-like activities of 1,8- and 1,4-cineoles

    Godfried Dougnon

    The 66th Annual Meeting of the Japanese Society of Pharmacognosy  2019 

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    Presentation type:Poster presentation  

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  • Sedative effects of essential oil from the leaves of Lantana camara

    Godfried Dougnon

    The 65th Annual Meeting of the Japanese Society of Pharmacognosy  2018 

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    Language:Japanese   Presentation type:Oral presentation (general)  

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  • Ethnopharmacological and ethnobotanical studies of plants used in the traditional treatment of high blood pressure in Central Benin

    Godfried Dougnon

    First MOU Symposium Kyoto University-Indonesia Matalam University  2017 

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    Language:English   Presentation type:Poster presentation  

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  • Ethnobotanical studies of plants used in the traditional treatment of hypertension in the Central Benin

    Godfried Dougnon

    Panafrican-paneuropean colloque COPED-ANSALB on Chemistry and Natural Resources, ISBA  2015 

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    Language:French   Presentation type:Oral presentation (general)  

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  • Effects of aqueous extracts of Heliotropium indicum and Crateva adansonii on high blood pressure of Wistar rats

    Godfried Dougnon

    First medico-pharmaceutical days of the Faculty of Health Sciences, Cotonou  2014 

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    Language:French   Presentation type:Oral presentation (general)  

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Awards

  • Best Presentation Award

    2021.4   The 2nd Pharmaceutical Research Exchange Salon (Kyoto, Japan)  

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  • MEXT Scholarship, Embassy Recommendation

    2016.4   Ministry of Education, Culture, Sports, Science and Technology (MEXT)  

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Teaching Experience (researchmap)

  • Pharmaceutical Botany

    Institution name:University of Abomey-Calavi/School of Pharmacy

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Teaching Experience

  • 学問の扉 知と方法の最前線

    2023
    Institution name:新潟大学