Updated on 2024/05/18

写真a

 
OSAWA Taeko
 
Organization
Graduate School of Medical and Dental Sciences Specially Appointed Associate Professor
Title
Specially Appointed Associate Professor
External link

Degree

  • 博士(医学) ( 2019.3   新潟大学 )

Research History

  • Niigata University   Graduate School of Medical and Dental Sciences   Specially Appointed Associate Professor

    2022.4

 

Papers

  • Pulse Pressure is a Stronger Predictor Than Systolic Blood Pressure for Severe Eye Diseases in Diabetes Mellitus.

    2019.4

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  • "Lifestyle Intervention with Smartphone app and isCGM for People at High Risk of Type 2 Diabetes: Randomized Trial". International journal

    Masaru Kitazawa, Yasunaga Takeda, Mariko Hatta, Chika Horikawa, Takaaki Sato, Taeko Osawa, Masahiro Ishizawa, Hiroshi Suzuki, Yasuhiro Matsubayashi, Kazuya Fujihara, Takaho Yamada, Hirohito Sone

    The Journal of clinical endocrinology and metabolism   2023.11

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    AIMS: Although conventional interventions for people at high risk of developing type 2 diabetes are usually conducted face-to-face, such interventions are burdensome for healthcare providers. We developed a lifestyle intervention program combining lifestyle coaching via a smartphone application augmented by intermittently scanned continuous glucose monitoring (isCGM) without burdening healthcare providers. Its effectiveness for glycemic control and body weight reduction in people at risk of type 2 diabetes was investigated. MATERIALS AND METHODS: For this 12-week randomized unblinded trial with offline recruitment, participants with HbA1c 5.6-6.4% or fasting blood glucose 110-125 mg/dl and body mass index (BMI) > 23 kg/m2 but <40 kg/m2 were randomly assigned to the Intervention group (App) and Control group (C). Primary endpoint was the difference in time in range (TIR) of blood glucose 70-140 mg/dL (3.9-7.8 mmol/L) before and after the study period between the two groups. RESULTS: Among 168 patients (mean age 48.1 y, mean BMI 26.6 kg/m2, and male 80.4%), 82 and 86 were assigned to the App group and C group, respectively. After 12 weeks, TIR of blood glucose 70-140 mg/dL significantly improved in the App group compared to the C group (-2.6 min/day vs. + 31.5 min/day, p = 0.03). Changes in time above range did not differ, whereas time below range (blood glucose <70 mg/dL;  + 23.5 min/day vs. -8.9 min/day, p = 0.02) improved in the App group. BMI (-0.26 vs. -0.59, p = 0.017) was reduced in the App group compared to the C group. CONCLUSION: Intervention with a smartphone app and isCGM increased glycemic control accompanied by decreased carbohydrate intake and weight loss. Further trials are needed to confirm whether these interventions can reduce incident type 2 diabetes.

    DOI: 10.1210/clinem/dgad639

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  • 心血管疾患 脂肪肝の表現型,及び2型糖尿病が心不全の新規発症に与えるインパクト

    松林 泰弘, 藤原 和哉, 山田 万祐子, 佐藤 隆明, 矢口 雄大, 山本 正彦, 石黒 創, 大澤 妙子, 北澤 勝, 岩永 みどり, 山田 貴穂, 曽根 博仁

    糖尿病合併症   37 ( Suppl.1 )   164 - 164   2023.9

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  • Retrospective cohort study to examine the association between serum amylase and the incidence of type 2 diabetes mellitus, Toranomon Hospital Health Management Center Study 23 (TOPICS 23). International journal

    Izumi Ikeda, Kazuya Fujihara, Taeko Osawa, Yasunaga Takeda, Mariko Hatta, Yasuhiro Matsubayashi, Satoru Kodama, Yasumichi Mori, Takashi Kadowaki, Ritsuko Honda, Yasuji Arase, Hirohito Sone

    BMJ open diabetes research & care   11 ( 4 )   2023.7

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    INTRODUCTION: Low serum amylase values are cross-sectionally associated with the prevalence of type 2 diabetes mellitus (T2DM) but have not been shown to be longitudinally associated with its incidence. This retrospective cohort (ie, historical cohort) study aimed to examine the association of previously lowered levels of serum amylase with incident T2DM. RESEARCH DESIGN AND METHODS: Examined were 8316 individuals who had annual health examinations for 6 years (ie, 7 times) at the Toranomon Hospital Health Management Center. The trajectory of serum amylase as the study exposure was classified into two elements: (1) serum amylase level at entry and (2) change in serum amylase, which was expressed as the annual change rate. The annual change rate was calculated by dividing the change in the amylase values according to follow-up periods. Regression analyses were performed to examine the association between low and decreased levels of serum amylase and the incidence of T2DM. RESULTS: Analyzed were 6917 individuals who had not developed T2DM within 1 year after cohort entry. T2DM thereafter occurred in 1021 patients. Cox regression indicated that the adjusted HR (95% CI) for incident T2DM for amylase ≤57 IU/L (quintile (Q) 1) was 0.97 (0.84 to 1.13) compared with amylase ≥58 IU/L (Q2-Q5). Logistic regression indicated that the adjusted OR (95% CI) for an annual change rate of amylase ≤-2.0% (Q1) vs ≥-1.9% (Q2-Q5) was 3.53 (3.00 to 4.16). The adjusted ORs were consistently significant throughout sensitivity analyses according to baseline amylase and the combination of age, body mass index, and hemoglobin A1c. CONCLUSIONS: Results showed that not low but previously decreased serum amylase was a risk factor for T2DM, suggesting the significance of periodic examinations of serum amylase values to detect individuals at high risk of T2DM.

    DOI: 10.1136/bmjdrc-2023-003482

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  • 耐糖能や年齢で層別化した血清アミラーゼ低値およびその経時的減少が2型糖尿病発症に及ぼす影響の縦断的検討

    池田 和泉, 藤原 和哉, 大澤 妙子, 武田 安永, 治田 麻里子, 松林 泰弘, 児玉 暁, 森 保道, 本田 律子, 門脇 孝, 荒瀬 康司, 曽根 博仁

    糖尿病   66 ( Suppl.1 )   S - 215   2023.4

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  • Association of the estimated glomerular filtration rate (eGFR) and/or proteinuria to predict the risk of initiation of dialysis in people with and without diabetes.

    Taeko Osawa, Kazuya Fujihara, Mayuko Harada Yamada, Yuta Yaguchi, Takaaki Sato, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Satoru Kodama, Hirohito Sone

    Diabetology international   14 ( 1 )   86 - 93   2023.1

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    AIMS: To determine the associations between combined urinary protein (UP) and a reduced estimated glomerular filtration rate (eGFR) and the risk of starting dialysis with or without diabetes mellitus (DM). METHODS: A nationwide database with claims data on 335,778 people with and without DM aged 19-72 years in Japan was used to elucidate the impact of the severities of UP and eGFR on starting dialysis. Initiation of dialysis was determined from claims using ICD-10 codes and medical procedures. Using multivariate Cox modeling, we investigated the severities of UP and eGFR to predict the initiation of dialysis with and without DM. RESULTS: Both eGFR < 60 and UP(+) were independent predictors for starting dialysis with and without DM, and their values exhibited a synergistic risk of dialysis. eGFR < 60 presented a nearly twofold risk for starting dialysis compared to UP(+) regardless of DM. Risk of starting dialysis was increased with UP(+) and eGFR ≥ 60 accompanied by DM although this association was not observed without DM. Those who had UP(-) and eGFR < 60 had a high risk of starting dialysis regardless of DM. Compared with DM(-)UP(-)eGFR ≥ 60, HRs for starting dialysis for DM(+)UP(+)eGFR ≥ 60, DM(+)UP(-)eGFR < 60 and DM(+)UP(+)eGFR < 60 significantly increased 17.7 (10.6-29.7), 25.5 (13.8-47.1) and 358.1 (239.1-536.5) times, respectively. CONCLUSIONS: eGFR < 60 and UP(+) together presented an extremely high risk of dialysis especially with DM. UP( +) increased the risk of starting dialysis regardless of the eGFR with DM. Both patient education and a treatment strategy by physicians might be helpful to avoid the progression of renal failure.

    DOI: 10.1007/s13340-022-00603-z

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  • Impact of metabolic syndrome and metabolic dysfunction-associated fatty liver disease on cardiovascular risk by the presence or absence of type 2 diabetes and according to sex. International journal

    Yasuhiro Matsubayashi, Kazuya Fujihara, Mayuko Yamada-Harada, Yurie Mitsuma, Takaaki Sato, Yuta Yaguchi, Taeko Osawa, Masahiko Yamamoto, Masaru Kitazawa, Takaho Yamada, Satoru Kodama, Hirohito Sone

    Cardiovascular diabetology   21 ( 1 )   90 - 90   2022.6

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    BACKGROUND: To determine the impact of metabolic syndrome (MetS) and/or metabolic dysfunction-associated fatty liver disease (MAFLD), which are pathophysiologically similar and include insulin resistance, on the development of new-onset cardiovascular disease with and without type 2 diabetes and according to sex. METHODS: This study included 570,426 individuals without a history of cardiovascular disease who were enrolled in a nationwide claims database from 2008 to 2016 and were classified by the presence or absence of MetS and/or MAFLD stratified by the presence or absence of type 2 diabetes and sex. The fatty liver index was used to determine the presence or absence of fatty liver that required a diagnosis of MAFLD. Risks of developing coronary artery disease (CAD) and cerebrovascular disease (CVD) in each category were analyzed using a multivariate Cox proportional hazard model. RESULTS: During a median follow-up of 5.2 years, 2252 CAD and 3128 CVD events occurred. Without type 2 diabetes the hazard ratio (HR) (95% CI) for CAD/CVD compared with neither MAFLD nor MetS was 1.32 (1.17-1.50)/1.41(1.28-1.57) for MAFLD only (without MetS), 1.78 (1.22-2.58)/1.66 (1.34-2.06) for MetS only (without MAFLD), and 2.10 (1.84-2.39)/1.73 (1.54-1.95) for MAFLD + MetS. For those with type 2 diabetes, the HR for CAD for MAFLD only (compared with neither MAFLD nor MetS) was 1.29 (1.06-1.58), for MetS only 1.34 (0.84-2.13), and for MAFLD + MetS 1.22 (1.02-1.47). For CVD, there was a significant increase in HR only in MAFLD + MetS [1.44 (1.18-1.76)]. The results of the analysis stratified by sex showed that MAFLD had a greater impact in men, and MetS had a greater impact in women regarding the development of CAD. CONCLUSIONS: Distinguishing between MetS and/or MAFLD in the presence or absence of type 2 diabetes and according to sex may aid in accurately identifying patients at high risk of cardiovascular disease.

    DOI: 10.1186/s12933-022-01518-4

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  • Impact of prior cerebrovascular disease and glucose status on incident cerebrovascular disease in Japanese.

    2021.9

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  • Associations of Systolic Blood Pressure and Diastolic Blood Pressure With the Incidence of Coronary Artery Disease or Cerebrovascular Disease According to Glucose Status.

    2021.9

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  • Rates and risk factors for amputation in people with diabetes in Japan: a historical cohort study using a nationwide claims database.

    2021.4

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  • Severity of hypertension as a predictor of initiation of dialysis among study participants with and without diabetes mellitus.

    2021.3

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  • Skipping breakfast, late-night eating and current smoking are associated with medication adherence in Japanese patients with diabetes.

    2020.12

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  • Association of increased hepatic insulin clearance and change in serum triglycerides or β-hydroxybutyrate concentration via the sodium/glucose-cotransporter 2 inhibitor tofogliflozin.

    2020.6

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  • Risk of coronary artery disease according to glucose abnormality status and prior coronary artery disease in Japanese men.

    2019.12

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  • Relationship Between Number of Multiple Risk Factors and Coronary Artery Disease Risk With and Without Diabetes Mellitus.

    2019.11

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  • 大血管障害 耐糖能状態及び心血管疾患既往の有無で層別化した、心血管疾患発症リスクの検討 Reviewed

    北澤 勝, 藤原 和哉, 山田 万祐子, 大澤 妙子, 山本 正彦, 矢口 雄大, 金子 正儀, 松林 泰弘, 山田 貴穂, 清田 浩康, 曽根 博仁

    糖尿病合併症   33 ( Suppl.1 )   242 - 242   2019.9

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  • Effect of family-oriented diabetes programs on glycemic control: A meta-analysis.

    2019.7

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  • Overt Proteinuria, Moderately Reduced eGFR and Their Combination Are Predictive of Severe Diabetic Retinopathy or Diabetic Macular Edema in Diabetes.

    2019.6

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  • 糖尿病の有無別にみた血糖・血圧・脂質・喫煙の各管理目標達成状況が冠動脈疾患発症に及ぼす影響 Reviewed

    原田 万祐子, 藤原 和哉, 大澤 妙子, 石澤 正博, 山本 正彦, 金子 正儀, 松林 泰弘, 清田 浩康, 山田 貴穂, 小川 渉, 曽根 博仁

    糖尿病   62 ( Suppl.1 )   S - 285   2019.4

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  • 耐糖能状態と心血管疾患既往の有無別に見たその後の心血管疾患発症リスク Reviewed

    北澤 勝, 藤原 和哉, 原田 万祐子, 大澤 妙子, 山本 正彦, 矢口 雄大, 金子 正儀, 松林 泰弘, 山田 貴穂, 清田 浩康, 曽根 博仁

    糖尿病   62 ( Suppl.1 )   S - 190   2019.4

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  • Higher pulse pressure predicts initiation of dialysis in Japanese patients with diabetes.

    2019.3

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  • Relationships among cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors in Japanese adolescents: Niigata screening for and preventing the development of non-communicable disease study-Agano (NICE EVIDENCE Study-Agano) 2.

    2018.6

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  • 指先穿刺による血糖およびHbA1c迅速測定をもちいた糖尿病啓発の取り組み Reviewed

    山田 貴穂, 石井 大, 武田 安永, 橋本 浩平, 三ツ間 友里恵, 張 かおり, 原田 万祐子, 白石 友信, 吉岡 大志, 山本 正彦, 大澤 妙子, 石黒 創, 金子 正儀, 鈴木 浩史, 松林 泰弘, 松永 佐澄志, 藤原 和哉, 岩永 みどり, 鈴木 亜希子, 羽入 修, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 377   2018.4

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MISC

  • 耐糖能およびHDL-C値によるLDL-C値が冠動脈疾患発症に及ぼす影響の検討

    山田 万祐子, 藤原 和哉, 大澤 妙子, 北澤 勝, 松林 泰弘, 矢口 雄大, 山本 正彦, 佐藤 隆明, 三ツ間 友里恵, 岩永 みどり, 山田 貴穂, 児玉 暁, 曽根 博仁

    糖尿病合併症   36 ( Suppl.1 )   173 - 173   2022.9

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  • 新たな総合体力指標を用いたメタボリックシンドロームの発症予測能の検討

    佐藤 隆明, 藤原 和哉, 山田 万祐子, 張 かおり, 矢口 雄大, 山本 正彦, 北澤 勝, 石黒 創, 大澤 妙子, 山田 貴穂, 加藤 公則, 曽根 博仁

    糖尿病   65 ( Suppl.1 )   S - 155   2022.4

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  • 小児における睡眠時間およびソーシャルジェットラグと過体重・肥満の関連

    塩崎 悠香, 藤原 和哉, 山田 万祐子, 大澤 妙子, 北澤 勝, 松林 泰弘, 矢口 雄大, 山本 正彦, 佐藤 隆明, 山田 貴穂, 曽根 博仁

    日本内分泌学会雑誌   98 ( 1 )   296 - 296   2022.4

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  • 耐糖能およびHDLコレステロール値別にみたLDLコレステロールが冠動脈疾患に及ぼす影響の検討

    山田 万祐子, 藤原 和哉, 大澤 妙子, 北澤 勝, 松林 泰弘, 矢口 雄大, 山本 正彦, 佐藤 隆明, 三ツ間 友里恵, 岩永 みどり, 山田 貴徳, 児玉 暁, 曽根 博仁

    糖尿病   65 ( Suppl.1 )   S - 186   2022.4

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  • HDLコレステロール値別にみたLDLコレステロールと冠動脈疾患との関連

    山田 万祐子, 藤原 和哉, 大澤 妙子, 北澤 勝, 松林 泰弘, 矢口 雄大, 山本 正彦, 佐藤 隆明, 三ツ間 友里恵, 岩永 みどり, 山田 貴穂, 児玉 暁, 曽根 博仁

    日本内分泌学会雑誌   98 ( 1 )   322 - 322   2022.4

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  • 日本人男性における耐糖能別にみた脳卒中既往がその後の脳卒中発症に与える影響

    山田 万祐子, 藤原 和哉, 大江 桃子, 大澤 妙子, 北澤 勝, 松林 泰弘, 佐藤 隆明, 矢口 雄大, 岩永 みどり, 山田 貴穂, 曽根 博仁

    糖尿病合併症   35 ( Suppl. )   174 - 174   2021.9

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  • 血清尿酸値と重症糖尿病網膜症との関係

    山本 正彦, 藤原 和哉, 矢口 雄大, 大澤 妙子, 山田 万祐子, 松林 泰弘, 長谷部 日, 山田 貴穂, 児玉 暁, 曽根 博仁

    糖尿病合併症   35 ( Suppl. )   268 - 268   2021.9

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  • 日本人男性における耐糖能と脳卒中既往がその後の脳卒中発症に与える影響 リアルワールドデータによる検討

    山田 万祐子, 藤原 和哉, 大江 桃子, 大澤 妙子, 北澤 勝, 松林 泰弘, 佐藤 隆明, 矢口 雄大, 岩永 みどり, 清田 浩康, 山田 貴穂, 曽根 博仁

    糖尿病   64 ( Suppl.1 )   III - 2   2021.5

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  • 心血管疾患既往の有無と耐糖能状態別に見たその後の心血管疾患発症リスク

    北澤 勝, 藤原 和哉, 山田 万祐子, 大澤 妙子, 矢口 雄大, 山本 正彦, 金子 正儀, 松林 泰弘, 山田 貴穂, 清田 浩康, 曽根 博仁

    日本内分泌学会雑誌   97 ( 1 )   274 - 274   2021.4

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  • 心血管疾患既往の有無と耐糖能状態別に見たその後の心血管疾患発症リスク

    北澤 勝, 藤原 和哉, 山田 万祐子, 大澤 妙子, 矢口 雄大, 山本 正彦, 金子 正儀, 松林 泰弘, 山田 貴穂, 清田 浩康, 曽根 博仁

    日本内分泌学会雑誌   97 ( 1 )   274 - 274   2021.4

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  • 心血管・動脈硬化 耐糖能別にみた収縮期血圧と冠動脈疾患、脳血管疾患発症との関連

    山田 万祐子, 藤原 和哉, 大澤 妙子, 矢口 雄大, 北澤 勝, 松林 泰弘, 岩永 みどり, 清田 浩康, 山中 菜詩, 山田 貴穂, 曽根 博仁

    糖尿病合併症   34 ( Suppl.1 )   219 - 219   2020.11

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  • 心血管・動脈硬化 耐糖能別にみた収縮期血圧と冠動脈疾患、脳血管疾患発症との関連

    山田 万祐子, 藤原 和哉, 大澤 妙子, 矢口 雄大, 北澤 勝, 松林 泰弘, 岩永 みどり, 清田 浩康, 山中 菜詩, 山田 貴穂, 曽根 博仁

    糖尿病合併症   34 ( Suppl.1 )   219 - 219   2020.11

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  • 耐糖能別にみた収縮期血圧が冠動脈/脳血管疾患に及ぼす影響の検討

    山田 万祐子, 藤原 和哉, 大澤 妙子, 北澤 勝, 松林 泰弘, 矢口 雄大, 岩永 みどり, 山中 菜詩, 清田 浩康, 山田 貴穂, 小川 渉, 曽根 博仁

    糖尿病   63 ( Suppl.1 )   S - 206   2020.8

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  • 糖尿病の有無別にみた収縮期血圧が透析開始に及ぼす影響

    大澤 妙子, 藤原 和哉, 山田 万祐子, 山本 正彦, 北澤 勝, 松林 泰弘, 岩永 みどり, 清田 浩康, 山田 貴穂, 曽根 博仁

    糖尿病   63 ( Suppl.1 )   S - 172   2020.8

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  • Factors Significantly Associated with Adherence to Diabetes Medications: Findings from a Large Japanese Claims Database

    Yuta Yaguchi, Kazuya Fujihara, Taeko Osawa, Masahiko Yamamoto, Masanori Kaneko, Masaru Kitazawa, Mayuko Harada, Yasuhiro Matsubayashi, Takaho Yamada, Nauta Yamanaka, Hiroyasu Seida, Hirohito Sone

    DIABETES   68   2019.6

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:AMER DIABETES ASSOC  

    DOI: 10.2337/db19-698-P

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  • 耐糖能状態と心血管疾患既往の有無別に見たその後の心血管疾患発症リスク

    北澤 勝, 藤原 和哉, 原田 万祐子, 大澤 妙子, 山本 正彦, 矢口 雄大, 金子 正儀, 松林 泰弘, 山田 貴穂, 清田 浩康, 曽根 博仁

    糖尿病   62 ( Suppl.1 )   S - 190   2019.4

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    Language:Japanese   Publisher:(一社)日本糖尿病学会  

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  • 糖尿病の有無別にみた血糖・血圧・脂質・喫煙の各管理目標達成状況が冠動脈疾患発症に及ぼす影響

    原田 万祐子, 藤原 和哉, 大澤 妙子, 石澤 正博, 山本 正彦, 金子 正儀, 松林 泰弘, 清田 浩康, 山田 貴穂, 小川 渉, 曽根 博仁

    糖尿病   62 ( Suppl.1 )   S - 285   2019.4

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    Language:Japanese   Publisher:(一社)日本糖尿病学会  

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  • Incidence and Risk Factors for Amputation in Patients with Diabetes in Japan-Historical Cohort Study Using a Nationwide Claims Database

    Masanori Kaneko, Kazuya Fujihara, Masahiko Yamamoto, Masaru Kitazawa, Masahiro Ishizawa, Taeko Osawa, Mayuko Harada, Yasuhiro Matsubayashi, Takaho Yamada, Hirohito Sone

    DIABETES   67   2018.7

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:AMER DIABETES ASSOC  

    DOI: 10.2337/db18-637-P

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  • Effect of Number of Achieved Targets for Risk Factors on Coronary Artery Disease (CAD) in Those With and Without Diabetes Mellitus (DM)

    Kazuya Fujihara, Yasuhiro Matsubayashi, Masaru Kitazawa, Masahiko Yamamoto, Taeko Osawa, Masanori Kaneko, Nauta Yamanaka, Hiroyasu Seida, Kiminori Kato, Satoru Kodama, Hirohito Sone

    DIABETES   67   2018.7

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:AMER DIABETES ASSOC  

    DOI: 10.2337/db18-442-P

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  • 指先穿刺による血糖およびHbA1c迅速測定をもちいた糖尿病啓発の取り組み

    山田 貴穂, 石井 大, 武田 安永, 橋本 浩平, 三ツ間 友里恵, 張 かおり, 原田 万祐子, 白石 友信, 吉岡 大志, 山本 正彦, 大澤 妙子, 石黒 創, 金子 正儀, 鈴木 浩史, 松林 泰弘, 松永 佐澄志, 藤原 和哉, 岩永 みどり, 鈴木 亜希子, 羽入 修, 曽根 博仁

    糖尿病   61 ( Suppl.1 )   S - 377   2018.4

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    Language:Japanese   Publisher:(一社)日本糖尿病学会  

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  • 当院通院中の糖尿病患者における皮膚AF(Autofluorescene)値測定の意義に関する検討

    川田 亮, 羽入 修, 古川 和郎, 石澤 正博, 山本 正彦, 大澤 妙子, 山田 貴穂, 皆川 真一, 鈴木 裕美, 山田 絢子, 鈴木 亜希子, 曽根 博仁

    新潟医学会雑誌   129 ( 8 )   482 - 482   2015.8

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    Language:Japanese   Publisher:新潟医学会  

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  • 巣症状を来したインスリノーマによる低血糖性脳症2例

    鈴木 達郎, 阿部 孝洋, 鈴木 亜希子, 北澤 勝, 皆川 真一, 山田 貴穂, 羽入 修, 曽根 博仁, 石澤 正博, 大澤 妙子

    日本内分泌学会雑誌   90 ( 1 )   319 - 319   2014.4

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    Language:Japanese   Publisher:(一社)日本内分泌学会  

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