Language：English   Publishing type：Research paper (scientific journal)   Publisher：PUBLIC LIBRARY SCIENCE  

Objectives
To evaluate the vascular architecture of the radial peripapillary capillaries (RPCs) and its relation with visual function in patients with open-angle glaucoma (OAG) and normal-tension glaucoma using spectral-domain optical coherence tomography (SD-OCT) angiography.
Subjects and methods
Clear OCT angiography images of blood vessels in the optic disc and peripapillary retina were obtained from 52 patients (52 eyes) aged 55.42 +/- 10.64 (range 28-72) years with primary OAG. The mean spherical equivalent was -3.19 +/- 2.31 diopters, and the mean deviation (MD) of the central 24/30-2 threshold test using the Humphrey Field Analyzer (HFA) was -10.47 +/- 7.99 dB. The correlations between the disappearance angle of the RPCs on OTC images, flow density (FD) and the circumpapillary retinal nerve fiber layer (cpRNFL) thickness, the angle of retinal nerve fiber layer (RNFL) defect, the MD and pattern standard deviation (PSD) values of the HFA central 24/30-2 threshold test using the Swedish interactive thresholding algorithm, the sensitivity threshold, age, corneal thickness, and refractive value were analyzed. In addition, the correlation between FD and the cpRNFL thickness was analyzed at FD measurement points.
Results
FD was significantly correlated with cpRNFL thickness, PSD value, MD value, and sensitivity threshold, whereas the disappearance angle of the RPCs was significantly correlated with the angle of the RNFL defect (P < 0.001), MD value (P < 0.01), and sensitivity threshold (P < 0.01). There was a negative correlation between FD and age (P < 0.05). The Pearson correlation coefficient of FD and cpRNFL thickness in the area surrounding the optic disc revealed the most significant correlation in the inferior visual field (r = 0.851, P < 0.001), followed by the superior visual field (r = 0.803, P < 0.001) and then the temporal visual field (r = 0.653, P < 0.001).
Conclusion
SD-OCT angiography enabled thorough observation of the RPCs. FD and the disappearance angle of the RPCs were significantly and independently correlated with glaucomarelated functional and morphological changes in the optic nerve, suggesting that these two factors are novel functional and morphological indicators of visual defects due to glaucoma.

DOI： 10.1371/journal.pone.0184301

Web of Science

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Authorship：Lead author   Language：Japanese  

CiNii Article

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/2015227955

Language：Japanese  

J-GLOBAL

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Language：English   Publisher：(公財)日本眼科学会  

J-GLOBAL

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Language：Japanese   Publisher：日本緑内障学会  

J-GLOBAL

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Language：Japanese   Publisher：日本緑内障学会  

J-GLOBAL

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Language：Japanese   Publisher：(公財)日本眼科学会  

J-GLOBAL

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Language：Japanese   Publisher：(公財)日本眼科学会  

J-GLOBAL

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Language：Japanese   Publisher：(株)メディカル葵出版  

目的:Humphrey 10-2視野(HFA10-2)における視野感度低下領域とシラスHD-OCT(カールツァイスメディテック)のganglion cell analysis(GCA)判定の相関を検討した。対象および方法:広義原発開放隅角緑内障53名53眼を対象とした後ろ向き研究。HFA10-2における測定点をGCA解析に準じて6セクターに分割し、トータル偏差で感度低下(1%以下)がみられるものを異常点とした。GCA各セクターにおける菲薄化をディビエーションマップからスコア化した(>5%、0;≦5%かつ>1%、1;≦1%、2)。半視野当たりのHFA異常点数とGCAスコア合計との相関について調べ、セクターごとの整合性についても検討した。結果:半視野当たりのHFA異常点数と対応するGCAスコアはいずれも有意な相関がみられた(上半0.74、下半0.53)。上鼻側セクターにおいて感度と特異度は高く(90%、100%)、下方および耳側セクターでは低くなる傾向があった。結論:GCA解析による判定は中心10°内視野障害を反映していると考えられる。(著者抄録)

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J01784&link_issn=&doc_id=20171107230025&doc_link_id=%2Fah9atgke%2F2017%2F003410%2F026%2F1465-1469%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fah9atgke%2F2017%2F003410%2F026%2F1465-1469%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：眼科臨床紀要会  

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Language：Japanese   Publisher：眼科臨床紀要会  

J-GLOBAL

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Language：Japanese   Publisher：眼科臨床紀要会  

J-GLOBAL

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Language：Japanese   Publisher：(公財)日本眼科学会  

J-GLOBAL

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Language：Japanese   Publisher：眼科臨床紀要会  

J-GLOBAL

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Language：English   Publishing type：Research paper, summary (international conference)   Publisher：ASSOC RESEARCH VISION OPHTHALMOLOGY INC  

Web of Science

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Event date： 2018.4 - 2018.5

Language：English   Presentation type：Poster presentation  

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Event date： 2018.4

Language：Japanese   Presentation type：Oral presentation (general)  

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Event date： 2017.9

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2017.6 - 2017.7

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Event date： 2015.10

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Event date： 2014.11

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Presentation type：Oral presentation (general)  

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Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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