Language：Japanese   Publisher：日本緑内障学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

This study investigated the influence of asymmetric corneal hysteresis (CH) on asymmetric visual field impairment between right and left eyes in patients with primary open-angle glaucoma (POAG) without a history of intraocular surgery. CH, corneal resistance factor (CRF), and corneal compensated intraocular pressure (IOPcc) were measured using the Ocular Response Analyzer. Differences between the eyes (right eye–left eye: DIFRL) and CH-based and in target parameters (higher CH eye–lower CH eye: DIFCH) were calculated in the same patient. In 242 phakic eyes of 121 patients, older age (p < 0.001), lower CH (p = 0.001), and lower CRF (p = 0.007) were significantly associated with worse standard automated perimetry (SAP) 24-2 mean deviation (MD). The DIFsRL in axial length (p = 0.003), IOPcc (p = 0.028), and CH (p = 0.001) were significantly associated with the DIFRL in SAP24-2 MD, but not in central corneal thickness (CCT), Goldmann applanation tonometry (GAT) measurement, and CRF. When dividing the patients into two groups based on the median of the CH DIFsCH (0.46), the DIFsCH in CRF (p < 0.001), IOPcc (p < 0.001), CCT (p = 0.004), SAP24-2 MD (p < 0.001), and SAP10-2 MD (p = 0.010) were significantly different between the groups. Large inter-eye asymmetry in CH is an important explanatory factor for disease worsening in patients with POAG.

DOI： 10.3390/jcm12134514

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Authorship：Lead author   Language：Japanese  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Hindawi Limited  

<italic>Purpose</italic>. To clarify the clinical features of patients with exfoliation glaucoma (XFG) requiring surgical intervention. <italic>Study Design</italic>. Retrospective study. <italic>Methods</italic>. The study included 46 eyes from 36 XFG patients, 85 eyes from 53 primary open-angle glaucoma (POAG) patients, and 54 eyes from 35 normal-tension glaucoma (NTG) patients. Age, duration of previous glaucoma treatment, intraocular pressure, medication scores, visual function, and surgical procedure were compared among the three patient groups. <italic>Results</italic>. The XFG group had the highest mean age (XFG: 75.7 ± 8.3 years, POAG: 65.8 ± 12.8 years, and NTG: 53.3 ± 12.8 years; <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>p</mml:mi><mml:mo>&lt;</mml:mo><mml:mn>0.001</mml:mn></mml:math>) and the shortest mean duration of previous treatment with glaucoma medication (XFG: 5.1 ± 3.5 years, POAG: 8.9 ± 6.9 years, and NTG: 8.9 ± 5.9 years; <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>p</mml:mi><mml:mo>&lt;</mml:mo><mml:mn>0.001</mml:mn></mml:math>). Intraocular pressure and medication scores were slightly higher in the XFG group than in the POAG group, although the differences were not significant. Among XFG patients, trabeculectomy was performed in 20 eyes from 16 patients (55.6%) and trabeculotomy was performed in 16 eyes from 14 patients (44.4%). Both trabeculectomy (3 eyes) and trabeculotomy (14 eyes) were performed in combination with cataract surgery. <italic>Conclusions</italic>. The XFG patients referred to our department for initial examination were older than the POAG and NTG patients, and their duration of treatment before referral was shorter. Moreover, intraocular pressure and the eye drop medication score were higher in the XFG patients. A significantly higher percentage of XFG patients required surgical intervention compared to patients with other disease types.

DOI： 10.1155/2020/9423756

PubMed

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Other Link： http://downloads.hindawi.com/journals/joph/2020/9423756.xml

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Ovid Technologies (Wolters Kluwer Health)  

PRECIS: The foveal avascular zone (FAZ) in optical coherence tomography angiography is significantly correlated with retinal inner layer thickness, Humphrey field analyzer (HFA) 10-2 sensitivity threshold, and mean deviation (MD) value in open-angle glaucoma patients. PURPOSE: The purpose of this study was to measure the FAZ area using optical coherence tomography angiography and investigate its relationship with retinal inner layer thickness and visual field defects in eyes with open-angle glaucoma. PARTICIPANTS AND METHODS: A total of 52 eyes with open-angle glaucoma from 52 patients. FAZ area was measured using optical coherence tomography angiography in angio-macula mode. Thicknesses of retinal nerve fiber layer (RNFL), ganglion cell layer plus inner plexiform layer (GCL+IPL), and ganglion cell complex (GCC) were determined using a 7 mm×7 mm macular (V) map via 3D-OCT. Correlations of FAZ area with sensitivity threshold measurements, foveal threshold (FT), and MD value in the HFA10-2 visual field were analyzed for each inner retinal layer. RESULTS: FAZ area was 0.26±0.07 mm; overall mean thicknesses were 19.14±6.55 μm (RNFL), 57.34±5.93 µm (GCL+IPL), and 75.87±10.96 μm (GCC); mean FT was 35.23±3.15 dB, and sensitivity threshold was 20.81±7.22 dB in the HFA10-2 visual field. FAZ area was significantly correlated with the thickness of individual retinal layers in the entire field (RNFL, P<0.001; GCL+IPL, P<0.001; GCC, P<0.001), sensitivity threshold (P=0.01), FT (P<0.001), and MD value (P=0.011). CONCLUSION: FAZ area was significantly negatively correlated with retinal inner layer thickness, sensitivity threshold, FT, and MD value in the HFA10-2 visual field.

DOI： 10.1097/ijg.0000000000001492

PubMed

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Public Library of Science (PLoS)  

DOI： 10.1371/journal.pone.0229867

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Authorship：Lead author   Language：Japanese  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(公財)日本眼科学会  

目的:正常眼圧緑内障の加療中に視交叉部腫瘍の合併が明らかになった4例を提示し,腫瘍合併を疑うべき所見について検討する.症例:合併した視交叉部腫瘍は,3例は下垂体腺腫,1例は鞍結節部髄膜腫であった.いずれの症例も急速な視野障害進行と片眼もしくは両眼の視力低下を伴っていた.2例では乳頭蒼白を伴っていたが,2例ではなかった.症例1の両耳側半盲所見は,10°内視野測定で初めて検出された.結論:緑内障症例に視交叉部腫瘍合併を疑う眼科的所見として,垂直経線を境界とする視野障害,急激な視力低下・視野悪化,乳頭蒼白などが挙げられるが,進行した緑内障症例では耳側半盲所見が判別しづらいことがあり,10°内視野測定が有用な場合がある.疑われる場合には積極的に頭蓋内画像検索を行うことが勧められる.(著者抄録)

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：PUBLIC LIBRARY SCIENCE  

Objectives
To evaluate the vascular architecture of the radial peripapillary capillaries (RPCs) and its relation with visual function in patients with open-angle glaucoma (OAG) and normal-tension glaucoma using spectral-domain optical coherence tomography (SD-OCT) angiography.
Subjects and methods
Clear OCT angiography images of blood vessels in the optic disc and peripapillary retina were obtained from 52 patients (52 eyes) aged 55.42 +/- 10.64 (range 28-72) years with primary OAG. The mean spherical equivalent was -3.19 +/- 2.31 diopters, and the mean deviation (MD) of the central 24/30-2 threshold test using the Humphrey Field Analyzer (HFA) was -10.47 +/- 7.99 dB. The correlations between the disappearance angle of the RPCs on OTC images, flow density (FD) and the circumpapillary retinal nerve fiber layer (cpRNFL) thickness, the angle of retinal nerve fiber layer (RNFL) defect, the MD and pattern standard deviation (PSD) values of the HFA central 24/30-2 threshold test using the Swedish interactive thresholding algorithm, the sensitivity threshold, age, corneal thickness, and refractive value were analyzed. In addition, the correlation between FD and the cpRNFL thickness was analyzed at FD measurement points.
Results
FD was significantly correlated with cpRNFL thickness, PSD value, MD value, and sensitivity threshold, whereas the disappearance angle of the RPCs was significantly correlated with the angle of the RNFL defect (P &lt; 0.001), MD value (P &lt; 0.01), and sensitivity threshold (P &lt; 0.01). There was a negative correlation between FD and age (P &lt; 0.05). The Pearson correlation coefficient of FD and cpRNFL thickness in the area surrounding the optic disc revealed the most significant correlation in the inferior visual field (r = 0.851, P &lt; 0.001), followed by the superior visual field (r = 0.803, P &lt; 0.001) and then the temporal visual field (r = 0.653, P &lt; 0.001).
Conclusion
SD-OCT angiography enabled thorough observation of the RPCs. FD and the disappearance angle of the RPCs were significantly and independently correlated with glaucomarelated functional and morphological changes in the optic nerve, suggesting that these two factors are novel functional and morphological indicators of visual defects due to glaucoma.

DOI： 10.1371/journal.pone.0184301

Web of Science

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Authorship：Lead author   Language：Japanese  

CiNii Article

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/2015227955

Language：Japanese   Publisher：日本緑内障学会  

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Language：Japanese  

J-GLOBAL

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Language：Japanese  

J-GLOBAL

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Language：Japanese  

J-GLOBAL

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Language：Japanese  

J-GLOBAL

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Language：English   Publisher：(公財)日本眼科学会  

J-GLOBAL

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Language：Japanese  

J-GLOBAL

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Language：English   Publisher：(公財)日本眼科学会  

J-GLOBAL

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Language：Japanese   Publisher：日本緑内障学会  

J-GLOBAL

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Language：Japanese   Publisher：日本緑内障学会  

J-GLOBAL

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Language：Japanese   Publisher：(公財)日本眼科学会  

J-GLOBAL

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Language：Japanese   Publisher：(公財)日本眼科学会  

J-GLOBAL

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Language：Japanese   Publisher：(株)メディカル葵出版  

目的:Humphrey 10-2視野(HFA10-2)における視野感度低下領域とシラスHD-OCT(カールツァイスメディテック)のganglion cell analysis(GCA)判定の相関を検討した。対象および方法:広義原発開放隅角緑内障53名53眼を対象とした後ろ向き研究。HFA10-2における測定点をGCA解析に準じて6セクターに分割し、トータル偏差で感度低下(1%以下)がみられるものを異常点とした。GCA各セクターにおける菲薄化をディビエーションマップからスコア化した(&gt;5%、0;≦5%かつ&gt;1%、1;≦1%、2)。半視野当たりのHFA異常点数とGCAスコア合計との相関について調べ、セクターごとの整合性についても検討した。結果:半視野当たりのHFA異常点数と対応するGCAスコアはいずれも有意な相関がみられた(上半0.74、下半0.53)。上鼻側セクターにおいて感度と特異度は高く(90%、100%)、下方および耳側セクターでは低くなる傾向があった。結論:GCA解析による判定は中心10°内視野障害を反映していると考えられる。(著者抄録)

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J01784&link_issn=&doc_id=20171107230025&doc_link_id=%2Fah9atgke%2F2017%2F003410%2F026%2F1465-1469%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fah9atgke%2F2017%2F003410%2F026%2F1465-1469%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：眼科臨床紀要会  

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Language：Japanese   Publisher：眼科臨床紀要会  

J-GLOBAL

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Language：Japanese   Publisher：眼科臨床紀要会  

J-GLOBAL

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Language：Japanese   Publisher：(公財)日本眼科学会  

J-GLOBAL

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Language：Japanese   Publisher：眼科臨床紀要会  

J-GLOBAL

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Language：English   Publishing type：Research paper, summary (international conference)   Publisher：ASSOC RESEARCH VISION OPHTHALMOLOGY INC  

Web of Science

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Event date： 2018.4 - 2018.5

Language：English   Presentation type：Poster presentation  

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Event date： 2018.4

Language：Japanese   Presentation type：Oral presentation (general)  

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Event date： 2017.9

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2017.6 - 2017.7

Language：English   Presentation type：Poster presentation  

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Event date： 2017.4

Language：Japanese   Presentation type：Oral presentation (general)  

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Event date： 2016.5

Language：English   Presentation type：Poster presentation  

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Event date： 2015.10

Language：Japanese   Presentation type：Oral presentation (general)  

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Event date： 2014.11

Language：Japanese   Presentation type：Oral presentation (general)  

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Presentation type：Oral presentation (general)  

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Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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