2024/04/24 更新

写真a

サワノ　ケンタロウ
澤野　堅太郎
SAWANO Kentaro
所属
医歯学総合病院 小児科 助教
職名
助教
外部リンク

学位

  • 学士（医学） （ 2011年3月   新潟大学 ）

研究キーワード

  • 小児内分泌

  • 糖尿病

研究分野

  • ライフサイエンス / 胎児医学、小児成育学

  • ライフサイエンス / 代謝、内分泌学

経歴

  • 新潟大学   医歯学総合病院 小児科   助教

    2022年6月 - 現在

学歴

  • 新潟大学   医学部   医学科

    2005年4月 - 2011年3月

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論文

  • A Study of Maternal Patients Diagnosed with Inborn Errors of Metabolism Due to Positive Newborn Mass Screening in Their Newborns. 国際誌

    Takanori Onuki, Shota Hiroshima, Kentaro Sawano, Nao Shibata, Yohei Ogawa, Keisuke Nagasaki, Hiromi Nyuzuki

    Children (Basel, Switzerland)   10 ( 8 )   2023年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: There are reports of mothers being diagnosed with inborn errors of metabolism (IEM) via positive newborn screening (NBS) of their newborns. Mothers with IEM are often considered to have mild cases of little pathological significance. Based in Niigata Prefecture, this study aimed to investigate mothers newly diagnosed with IEM via positive NBS in their newborns using tandem mass spectrometry, and to clarify the disease frequency and severity. METHODS: This was a single-institution, population-based, retrospective study. The subjects were mothers whose newborns had false-positive NBS, among 80,410 newborns who underwent NBS between April 2016 and May 2021. RESULT: there were 3 new mothers were diagnosed with IEM (2 with primary systemic carnitine deficiency (PCD) and 1 with 3-methylcrotonyl-CoA carboxylase deficiency) out of 5 who underwent examination among 18 false positives. The opportunity for diagnosis was low C0 and high C5-OH acylcarnitine levels in their newborn. Two novel SLC22A5 variants (c.1063T > C/c.1266A > G) were identified in patients with PCD. None of the patients had any complications at the time of diagnosis, but two patients showed improvement in fatigue and headache after taking oral carnitine. CONCLUSION: New mothers with IEM cannot be considered as mild cases and need to be treated when necessary. The two novel SLC22A5 variants further expand the variant spectrum of PCD.

    DOI： 10.3390/children10081341

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  • Klinefelter syndrome with penoscrotal transposition and diphallia: A case study. 国際誌

    Yugo Kawakami, Kentaro Sawano, Nao Shibata, Takayuki Kaneko, Keisuke Nagasaki

    Congenital anomalies   63 ( 4 )   125 - 126   2023年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1111/cga.12517

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  • Expanding the phenotypic spectrum of ARCN1-related syndrome

    Alyssa L. Ritter, Jessica Gold, Hiroshi Hayashi, Amanda M. Ackermann, Stephanie Hanke, Cara Skraban, Sanmati Cuddapah, Elizabeth Bhoj, Dong Li, Yukiko Kuroda, Jessica Wen, Ryojun Takeda, Audrey Bibb, Salima El Chehadeh, Amélie Piton, Jeanine Ohl, Mary K. Kukolich, Keisuke Nagasaki, Kohji Kato, Tomoo Ogi, Tricia Bhatti, Pierre Russo, Bryan Krock, Jill R. Murrell, Jennifer A. Sullivan, Vandana Shashi, Nicholas Stong, Hakon Hakonarson, Kentaro Sawano, Erin Torti, Rebecca Willaert, Yue Si, William Ross Wilcox, Katrine Verena Wirgenes, Kristian Thomassen, Katherine Carlotti, Angelika Erwin, Joanna Lazier, Thorsten Marquardt, Miao He, Andrew C. Edmondson, Kosuke Izumi

    Genetics in Medicine   24 ( 6 )   1227 - 1237   2022年6月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

    DOI： 10.1016/j.gim.2022.02.005

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  • A 7-year-old boy with central diabetes insipidus presenting with thickened pituitary stalk and anti-rabphilin-3A antibody positivity. 国際誌

    Kazutaka Morota, Hiroaki Tadokoro, Kentaro Sawano, Kenichi Watanabe, Naoko Iwata, Haruki Fujisawa, Atsushi Suzuki, Yoshihisa Sugimura, Keisuke Nagasaki

    Journal of pediatric endocrinology & metabolism : JPEM   35 ( 5 )   687 - 690   2022年5月

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    記述言語：英語  

    OBJECTIVES: A highly invasive pathological diagnosis is necessary to differentiate central diabetes insipidus (CDI) with a thickened pituitary stalk. Lymphocytic infundibulo-hypophysitis (LIH) due to autoimmune involvement of the pituitary stalk is a differentiating disease, and anti-rabphilin-3A antibody (Rab3A-Ab) positivity was recently reported. CASE PRESENTATION: A 7-year-old boy was diagnosed with CDI after having polyuria for two months. He showed growth hormone deficiency with reduced growth rate. Brain magnetic resonance imaging (MRI) revealed a thickened pituitary stalk. The placental alkaline phosphatase level of the cerebrospinal fluid, tumor marker for germ cell tumors, was below the level of sensitivity. No skin or bone findings suggestive of Langerhans cell histiocytosis were detected. Eight months after CDI onset, Rab3A-Ab was positive, and MRI showed shrinking of the thickened pituitary stalk, leading to the diagnosis with LIH. CONCLUSIONS: Rab3A-Ab is a useful adjunctive diagnostic tool for childhood-onset LIH.

    DOI： 10.1515/jpem-2021-0674

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  • Infantile-Onset Isolated Neurohypophyseal Langerhans Cell Histiocytosis with Central Diabetes Insipidus: A Case Report. 国際誌

    Mizuki Tani, Shota Hiroshima, Hidetoshi Sato, Kentaro Sawano, Yohei Ogawa, Masaru Imamura, Makoto Oishi, Keisuke Nagasaki

    Children (Basel, Switzerland)   9 ( 5 )   2022年5月

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    記述言語：英語  

    Central diabetes insipidus (CDI) is a rare disease in children and has a variety of etiologies. The major causes of CDI with pituitary stalk thickening (PST) are germinoma, Langerhans cell histiocytosis (LCH), and Lymphocytic infundibulo-neurohypophysitis, which are difficult to differentiate by imaging and require pathological diagnosis. We report a case of infantile-onset isolated neurohypophyseal LCH diagnosed by pathological findings. A 2-year-old girl presented with polydipsia and polyuria. CDI was diagnosed and treatment with oral desmopressin was initiated. Magnetic resonance imaging (MRI) of the head showed PST and absence of high-signal intensity of posterior pituitary on T1-weighted images. Follow-up MRI scans showed that the tumor mass was gradually increasing and extending posteriorly toward the area near the mamillary body. Simultaneously, anterior pituitary dysfunction was observed. She underwent a biopsy of the PST and LCH was diagnosed by immunohistochemical analysis. DNA analysis showed no BRAF V600E mutation. Monotherapy with 2-Chlorodeoxyadenosine reduced the tumor size but did not improve pituitary function. Isolated neurohypophyseal LCH should be considered in infantile-onset cases of CDI with PST. 2-CdA treatment resulted in rapid PST shrinkage. Further cases are needed to determine whether early diagnosis and treatment can prevent anterior pituitary dysfunction.

    DOI： 10.3390/children9050716

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  • Asymmetrical Graves' disease in children: potential usefulness of potassium iodide monotherapy. 国際誌

    Kyoko Fukahori, Kentaro Sawano, Hiroshi Yoshida, Keisuke Nagasaki

    BMJ case reports   15 ( 4 )   2022年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    A male junior high school student presented with failure to gain weight and acceleration of growth for 2 years. Free triiodothyronine and free thyroxine levels were elevated, and the thyroid-stimulating hormone (TSH) level was suppressed. TSH receptor antibody (TRAb) and thyroid-stimulating antibody were negative. On I-123 thyroid scintigraphy, iodine uptake was most pronounced in the upper pole of the right lobe. The patient was initially diagnosed with asymmetrical TRAb-negative Graves' disease (GD). His thyroid hormone level normalised with potassium iodide (KI) alone, and he became TRAb-positive 4 months after the initiation of KI therapy. This case demonstrates a rare presentation of GD that was initially TRAb-negative, which had asymmetrical iodine uptake on a thyroid scan and was confirmed to be TRAb positivity during the follow-up. KI monotherapy could be one of the effective treatment options for GD that is initially TRAb-negative.

    DOI： 10.1136/bcr-2022-249571

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  • A Japanese family with a heterozygous novel mutation in the Indian hedgehog gene exhibiting a broad spectrum of clinical features and radiological findings. 国際誌

    Takanori Onuki, Nao Shibata, Shota Hiroshima, Kentaro Sawano, Keisuke Nagasaki

    Congenital anomalies   62 ( 1 )   47 - 48   2022年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1111/cga.12445

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  • Carotenoderma with hypothyroidism

    Kentaro Sawano, Keisuke Nagasaki

    Archives of Disease in Childhood   107 ( 6 )   615 - 615   2021年11月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：BMJ  

    DOI： 10.1136/archdischild-2021-323051

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  • A case of adolescent trichorhinophalangeal syndrome undergoing pelvic osteotomy for bilateral acetabular dysplasia.

    Kentaro Sawano, Hiromi Nyuzuki, Keisuke Nagasaki, Hayato Suzuki, Ken Suda, Dai Miyasaka, Norio Imai, Akihiko Saitoh

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association   2021年9月

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  • Two cases of cytochrome P450 oxidoreductase deficiency with severe scoliosis and surgery requirement. 国際誌

    Takanori Onuki, Yoshiaki Ohtsu, Shota Hiroshima, Kentaro Sawano, Keisuke Nagasaki

    Congenital anomalies   61 ( 5 )   202 - 203   2021年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1111/cga.12434

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  • Re-Evaluation of the Prevalence of Permanent Congenital Hypothyroidism in Niigata, Japan: A Retrospective Study. 国際誌

    Keisuke Nagasaki, Hidetoshi Sato, Sunao Sasaki, Hiromi Nyuzuki, Nao Shibata, Kentaro Sawano, Shota Hiroshima, Tadashi Asami

    International journal of neonatal screening   7 ( 2 )   2021年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Although newborn screening (NBS) for congenital hypothyroidism (CH) in Japan started more than 40 years ago, the prevalence of CH remains unclear. Prevalence estimations among NBS-positive CH individuals include those with transient hypothyroidism and transient hyperthyrotropinemia, and re-evaluation with increasing age is necessary to clarify the actual incidence. Thus, we re-evaluated the incidence of permanent CH. Of the 106,114 patients who underwent NBS in the Niigata Prefecture, Japan, between April 2002 and March 2006, 116 were examined further due to high thyroid-stimulating hormone levels (>8 mIU/L) and were included in the study. We retrospectively evaluated their levothyroxine sodium (LT4) replacement therapy status from the first visit to 15 years of age. Of the 116 NBS-positive patients, 105 (91%) were initially examined in our department. Of these, 72 (69%) started LT4 replacement therapy on the first visit. Subsequently, 27 patients continued LT4 replacement until 15 years of age after multiple re-evaluations. The prevalence of permanent CH in the Niigata Prefecture during this period was 1 in 2500-3500 children. Ultimately, 62.5% of patients on LT4 replacement discontinued treatment by 15 years of age. This is the first study to clarify the true prevalence of permanent CH in Japan.

    DOI： 10.3390/ijns7020027

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  • 小児期発症バセドウ病におけるSIGLEC1 mRNA定量の検討

    廣嶋 省太, 澤野 堅太郎, 柴田 奈央, 入月 浩美, 佐々木 直, 小川 洋平, 橋本 貢士, 長崎 啓祐

    日本内分泌学会雑誌   96 ( 1 )   261 - 261   2020年8月

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    記述言語：日本語   出版者・発行元：(一社)日本内分泌学会  

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  • Letter to the Editor: Testosterone priming increased growth hormone peak levels in the stimulation test and suppressed gonadotropin secretion in three Japanese adolescent boys.

    Kentaro Sawano, Keisuke Nagasaki

    Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology   29 ( 4 )   201 - 201   2020年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1297/cpe.29.201

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  • Timing of hyponatremia development in patients with salt-wasting-type 21-hydroxylase deficiency.

    Rohi Shima, Kentaro Sawano, Nao Shibata, Hiromi Nyuzuki, Sunao Sasaki, Hidetoshi Sato, Yohei Ogawa, Yuki Abe, Keisuke Nagasaki, Akihiko Saitoh

    Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology   29 ( 3 )   105 - 110   2020年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Newborn screening (NBS) can detect 21-hydroxylase deficiency (21-OHD), allowing for early treatment initiation. However, many patients present with adrenal crises or hyponatremia at their first visit. Age (in days) of hyponatremia development in infants with salt-wasting (SW)-type 21-OHD remains unclear. Therefore, we determined the earliest age of hyponatremia diagnosis in this retrospective observational study using medical records of 40 patients with classic 21-OHD in Niigata Prefecture, Japan, from April 1989 to March 2019. We determined the earliest diagnosis of hyponatremia (serum sodium levels < 130 mEq/L) and created a sodium decrease rate model to estimate hyponatremia development age. Of 23 patients with SW-type 21-OHD, 10 (43.5%) were identified during NBS; the earliest case to present with hyponatremia was at day 7. Serum sodium levels were significantly and negatively correlated with age in days, and hyponatremia was estimated to develop at 6.6 d after birth. Genotype or serum 17-hydroxyprogesterone levels were not associated with sodium decrease rate. Thus, hyponatremia development age is earlier (within 7 d) than the previously described time-point (10-14 d) in infants with SW-type 21-OHD. Efforts to reduce the time lag from obtaining results to consultation may be required in patients with high 17-hydroxyprogesterone levels on NBS.

    DOI： 10.1297/cpe.29.105

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  • 1A型糖尿病におけるインスリン治療開始前の低血糖 後方視的観察研究

    蜂屋 瑠見, 山口 健史, 渡邊 さやか, 澤野 堅太郎, 森川 俊太郎, 中村 明枝, 長谷川 行洋

    糖尿病   62 ( Suppl.1 )   S - 286   2019年4月

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    記述言語：日本語   出版者・発行元：(一社)日本糖尿病学会  

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  • 小児糖尿病性ケトアシドーシスにおける意識障害の検討

    向井 純平, 秋山 類, 堀川 慎二郎, 荻原 重俊, 小谷 匡史, 居石 崇志, 齊藤 修, 清水 直樹, 澤野 堅太郎, 蜂屋 瑠見, 長谷川 行洋

    日本小児科学会雑誌   123 ( 2 )   231 - 231   2019年2月

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    記述言語：日本語   出版者・発行元：(公社)日本小児科学会  

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  • Hypoglycemia in type 1A diabetes can develop before insulin therapy: A retrospective cohort study. 査読 国際誌

    Takeshi Yamaguchi, Rumi Hachiya, Sayaka Watanabe-Yamamoto, Kentaro Sawano, Shuntaro Morikawa, Akie Nakamura, Yukihiro Hasegawa

    Diabetes research and clinical practice   147   87 - 92   2019年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    AIMS: There are as yet no cohort studies of hypoglycemia in type 1 diabetes before starting insulin therapy. Our aim was to determine the frequency and clinical features of hypoglycemia in patients with type 1A diabetes prior to commencing insulin therapy. METHODS: Eighty-seven patients with type 1A diabetes were enrolled, and a retrospective chart review of the patients was conducted. RESULTS: Hypoglycemia before insulin therapy occurred in six of 87 patients (6.9%). The HbA1c levels at the diagnosis of type 1A diabetes in the hypoglycemia group were lower than in the non-hypoglycemia group (median: 7.3% (56 mmol/mol) vs. 11.9% (106 mmol/mol), p < 0.0001). Similarly, the 24-hour urinary C-peptide (UCPR) levels of the former group were higher than those of the latter group (16.5 μg/day/m2 vs. 7.0 μg/day/m2, p = 0.0075). Hypoglycemic episodes occurred mostly in the postprandial period and gradually disappeared with a decrease in insulin secretion. CONCLUSIONS: We demonstrated that some patients with type 1A diabetes experience hypoglycemic episodes before insulin therapy. Patients with early-stage type 1A diabetes with relatively low HbA1c or high UCPR have a risk of hypoglycemia. These findings may impact when and how insulin is introduced in the treatment of early-stage type 1A diabetes.

    DOI： 10.1016/j.diabres.2018.11.011

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