Updated on 2024/05/06

写真a

 
SUWABE Tatsuya
 
Organization
University Medical and Dental Hospital . Assistant Professor
Title
Assistant Professor
External link

Degree

  • 博士（医学） ( 2020.3   新潟大学 )

  • 学士（医学） ( 2013.3   新潟大学 )

Research Interests

  • 造血器腫瘍

  • 腫瘍免疫

  • 造血幹細胞移植

  • 細胞治療

Research Areas

  • Life Science / Hematology and medical oncology

  • Life Science / Immunology

Research History (researchmap)

  • 新潟大学医歯学総合病院   血液内分泌代謝科   医員

    2017.8 - 2022.10

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Research History

  • Niigata University   University Medical and Dental Hospital   Assistant Professor

    2022.11

Education

  • Niigata University   医歯学総合研究科

    2017.4 - 2021.3

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  • Niigata University   Faculty of Medicine

    2007.4 - 2013.3

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Professional Memberships

 

Papers

  • Reduced chondroitin sulfate content prevents diabetic neuropathy through transforming growth factor-β signaling suppression. International journal

    Hajime Ishiguro, Takashi Ushiki, Atsuko Honda, Yasuhiro Yoshimatsu, Riuko Ohashi, Shujiro Okuda, Asami Kawasaki, Kaori Cho, Suguru Tamura, Tatsuya Suwabe, Takayuki Katagiri, Yiwei Ling, Atsuhiko Iijima, Tadahisa Mikami, Hiroshi Kitagawa, Akiyoshi Uemura, Kazunori Sango, Masayoshi Masuko, Michihiro Igarashi, Hirohito Sone

    iScience   27 ( 4 )   109528 - 109528   2024.4

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    Diabetic neuropathy (DN) is a major complication of diabetes mellitus. Chondroitin sulfate (CS) is one of the most important extracellular matrix components and is known to interact with various diffusible factors; however, its role in DN pathology has not been examined. Therefore, we generated CSGalNAc-T1 knockout (T1KO) mice, in which CS levels were reduced. We demonstrated that diabetic T1KO mice were much more resistant to DN than diabetic wild-type (WT) mice. We also found that interactions between pericytes and vascular endothelial cells were more stable in T1KO mice. Among the RNA-seq results, we focused on the transforming growth factor β signaling pathway and found that the phosphorylation of Smad2/3 was less upregulated in T1KO mice than in WT mice under hyperglycemic conditions. Taken together, a reduction in CS level attenuates DN progression, indicating that CS is an important factor in DN pathogenesis.

    DOI： 10.1016/j.isci.2024.109528

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  • Characterization of Leukocyte- and Platelet-Rich Plasma Derived from Female Collage Athletes: A Cross-Sectional Cohort Study Focusing on Growth Factor, Inflammatory Cytokines, and Anti-Inflammatory Cytokine Levels. International journal

    Tomoharu Mochizuki, Takashi Ushiki, Katsuya Suzuki, Misato Sato, Hajime Ishiguro, Tatsuya Suwabe, Mutsuaki Edama, Go Omori, Noriaki Yamamoto, Tomoyuki Kawase

    International journal of molecular sciences   24 ( 17 )   2023.9

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    Platelet-rich plasma (PRP) has been increasingly used in sports medicine owing to its various advantages. The purpose of our project was to standardize the parameters before performing large-scale clinical trials in the near future to precisely evaluate individual PRP quality. To examine the effects of regular exercise on PRP quality, this study focused on young female athletes, who have been relatively less studied. Blood samples were obtained from female college athletes (n = 35) and ordinary healthy adults (n = 30), which were considered as controls, and leukocyte-rich PRP (L-PRP) was prepared manually. Body composition indices were determined using a bathroom weight scale equipped with an impedance meter. Growth factors and cytokines were quantified using ELISA kits. Platelet-derived growth factor-BB (PDGF-BB) and Transforming-growth factors β1 (TGFβ1) levels (per platelet) in L-PRP were significantly lower in female athletes than in controls. In contrast, Interleukin-1β and Interleukin 1 receptor antagonist (IL-1RA) levels (per platelet and L-PRP) in L-PRP were significantly higher in athletes, and this difference was more prominent in IL-1RA. These findings suggest that L-PRP from athletes may facilitate the inflammatory phase of the healing process by regulating the pro-inflammatory and anti-inflammatory balance. These chemical compositions can be adopted as "must-check" parameters to characterize individual PRP preparations prior to clinical trials.

    DOI： 10.3390/ijms241713592

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  • Genetic manipulation resulting in decreased donor chondroitin sulfate synthesis mitigates hepatic GVHD via suppression of T cell activity. International journal

    Suguru Tamura, Hajime Ishiguro, Tatsuya Suwabe, Takayuki Katagiri, Kaori Cho, Kyoko Fuse, Yasuhiko Shibasaki, Tadahisa Mikami, Takero Shindo, Hiroshi Kitagawa, Michihiro Igarashi, Hirohito Sone, Masayoshi Masuko, Takashi Ushiki

    Scientific reports   13 ( 1 )   13098 - 13098   2023.8

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    Donor T cell activation, proliferation, differentiation, and migration are the major steps involved in graft-versus-host disease (GVHD) development following bone marrow transplantation. Chondroitin sulfate (CS) proteoglycan is a major component of the extracellular matrix and causes immune modulation by interacting with cell growth factors and inducing cell adhesion. However, its precise effects on immune function are unclear than those of other proteoglycan families. Thus, we investigated the significance of CS within donor cells in acute GVHD development utilizing CSGalNAc T1-knockout (T1KO) mice. To determine the effects of T1KO, the mice underwent allogenic bone marrow transplantation from major histocompatibility complex-mismatched donors. While transplantation resulted in hepatic GVHD with inflammatory cell infiltration of both CD4+ and CD8+ effector memory T cells, transplantation in T1KO-donors showed milder cell infiltration and improved survival with fewer splenic effector T cells. In vitro T-cell analyses showed that the ratio of effector memory T cells was significantly lower via phorbol myristate acetate/ionomycin stimulation. Moreover, quantitative PCR analyses showed significantly less production of inflammatory cytokines, such as IFN-γ and CCL-2, in splenocytes of T1KO mice. These results suggest that reduction of CS in donor blood cells may suppress the severity of acute GVHD after hematopoietic stem cell transplantation.

    DOI： 10.1038/s41598-023-40367-3

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  • Strategic analysis of body composition indices and resting platelet ATP levels in professional soccer players for better platelet-rich plasma therapy. International journal

    Takashi Ushiki, Tomoharu Mochizuki, Katsuya Suzuki, Masami Kamimura, Hajime Ishiguro, Tatsuya Suwabe, Satoshi Watanabe, Go Omori, Noriaki Yamamoto, Tomoyuki Kawase

    Frontiers in bioengineering and biotechnology   11   1255860 - 1255860   2023

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    Background: Autologous platelet-rich plasma (PRP) therapy is ambiguously thought to be more effective in elite athletes than in sedentary patients, although the possible importance of recipient responsiveness remains poorly understood. To address this issue, along with the well-known PRP quality, in this initial study, we evaluated two candidate biomarkers: body composition indices (BCIs), which reflect systemic physical conditions, and resting platelet ATP levels, which reflect platelet energy expenditure and the mass of energy generation units. Methods: In this cross-sectional cohort study, blood samples were collected from male professional soccer players (PSPs) on a local professional team during the off-season and platelet ATP levels were quantified using an ATP luminescence assay kit. BCIs were measured using the body mass impedance method. Age-matched male sedentary participants were used as the controls. Results: Among the BCIs, the body mass index, basal metabolic rate (BMR), and skeletal muscle weight levels were higher in the PSPs than in the controls. The platelet ATP levels in the PSPs group were significantly lower than those in the control group. The correlation between BMR and platelet ATP levels was moderately negative in the control group, but weakly positive in the PSPs group. Conclusion: Owing to regular physical exercise, PSPs had higher BMR levels and lower platelet ATP levels without a significant mutual correlation compared to sedentary controls. This study did not indicate the influence of these biomarkers on the success of PRP therapy but provided evidence for a better understanding of PRP therapy, particularly for elite athletes.

    DOI： 10.3389/fbioe.2023.1255860

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  • WT1ペプチドワクチン投与後10年間以上にわたり持続するWT1特異的な細胞傷害性T細胞

    諏訪部 達也, 柴崎 康彦, 田村 秀, 片桐 隆幸, 井田 桃里, 布施 香子, 牛木 隆志, 曽根 博仁, 成田 美和子, 増子 正義

    日本血液学会学術集会   84回   117 - 117   2022.10

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  • 同種移植後day30の末梢血CD8TN、CD4TEM割合は急性GVHD発症のバイオマーカーとなる

    片桐 隆幸, 古山 悠里, 米沢 穂高, 諏訪部 達也, 布施 香子, 柴崎 康彦, 瀧澤 淳, 曽根 博仁, 増子 正義

    日本血液学会学術集会   84回   880 - 880   2022.10

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  • 単一施設における節外性NK/T細胞リンパ腫、鼻腔(ENKL)における26例の後方視的解析 EBV-DNA定量の有用性

    山田 隆, 古山 悠里, 水戸部 正樹, 米沢 穂高, 鈴木 隆晴, 諏訪部 達也, 片桐 隆幸, 河本 啓介, 布施 香子, 柴崎 康彦, 増子 正義, 大島 孝一, 曽根 博仁, 瀧澤 淳

    日本血液学会学術集会   84回   294 - 294   2022.10

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  • 当科におけるIVLBCL22例の後方視的解析

    鈴木 隆晴, 水戸部 正樹, 武田 ルイ, 諏訪部 達也, 片桐 隆幸, 河本 啓介, 宮腰 淑子, 北嶋 俊樹, 小堺 貴司, 柴崎 康彦, 黒田 裕行, 棗田 学, 大島 孝一, 曽根 博仁, 瀧澤 淳

    日本血液学会学術集会   84回   557 - 557   2022.10

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  • Intensive oral care can reduce bloodstream infection with coagulase-negative staphylococci after neutrophil engraftment in allogeneic hematopoietic stem-cell transplantation International journal

    Tatsuya Suwabe, Kyoko Fuse, Kouji Katsura, Marie Soga, Takayuki Katagiri, Yasuhiko Shibasaki, Miwako Narita, Hirohito Sone, Masayoshi Masuko

    Supportive Care in Cancer   30 ( 1 )   475 - 485   2022.1

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    PURPOSE: Bloodstream infection (BSI) is a major complication of allogeneic hematopoietic stem-cell transplantation (allo-SCT). There are several causes of BSI; in particular, severe oral mucositis (OM) can induce BSI due to coagulase-negative staphylococci (CoNS). The OM severity may be reduced with intensive oral care. Thus, we evaluated whether the type of oral care affects the BSI incidence eventually. METHOD: We performed retrospective analysis on 206 recipients who underwent allo-SCT from 2006 to 2017 at our institute. Intensive oral care by a dental specialist was performed for 111 recipients (intensive-care group) and self-oral care was performed by 95 recipients (self-care group). Incidence of BSI was assessed by type of the oral care, before neutrophil engraftment (pre-E-BSI) and after neutrophil engraftment (post-E-BSI) period until 180 days after allo-SCT. RESULT: A total of 112 BSI occurred in 90 of the 206 recipients and 120 bacteria were identified, with CoNS being the most prevalent. There was no significant difference in the incidence of pre-E-BSI between the self-care and intensive-care groups (30.8% and 30.6%, respectively; P = 0.508). Meanwhile, the incidence of post-E-BSI was significantly lower in the intensive-care group than in the self-care group (14.3% and 28.6%; P = 0.008). In addition, the intensive-care group had significantly lower incidence of post-E-BSI with CoNS than the self-care group (8.5% and 21.5%, respectively; P = 0.009). CONCLUSION: Intensive oral care through the period of allo-HCT can significantly reduce the post-E-BSI occurrence, especially due to CoNS.

    DOI： 10.1007/s00520-021-06447-8

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  • Altered microbiota by a high-fat diet accelerates lethal myeloid hematopoiesis associated with systemic SOCS3 deficiency International journal

    Kaori Cho, Takashi Ushiki, Hajime Ishiguro, Suguru Tamura, Masaya Araki, Tatsuya Suwabe, Takayuki Katagiri, Mari Watanabe, Yoko Fujimoto, Riuko Ohashi, Yoichi Ajioka, Ippei Shimizu, Shujiro Okuda, Masayoshi Masuko, Yoshimi Nakagawa, Hideyo Hirai, Warren S. Alexander, Hitoshi Shimano, Hirohito Sone

    iScience   24 ( 10 )   103117 - 103117   2021.10

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    The suppressors of cytokine signaling (SOCS) proteins are negative regulators of cytokine signaling required to prevent excessive cellular responses. In particular, SOCS3 is involved in the regulation of metabolic syndromes, such as obesity and diabetes, by suppressing leptin and insulin signals. SOCS3 also suppresses the inflammatory response associated with metabolic stress, but this specific role remains undefined. Wild-type mice on a high-fat diet (HFD) exhibited only fatty liver, whereas systemic deletion of SOCS3 resulted in excessive myeloid hematopoiesis and hepatic inflammation. In addition, depletion of the gut microbiota resulted in considerable improvement in excess granulopoiesis and splenomegaly, halting the progression of systemic inflammation in SOCS3KO mice on the HFD. This result suggests that intestinal dysbiosis is involved in inflammation associated with SOCS3KO. Although contributing to diet-induced obesity and fatty liver, SOCS3 is nevertheless critical to suppress excess myeloid hematopoiesis and severe systemic inflammation associated with intestinal dysbiosis on HFD.

    DOI： 10.1016/j.isci.2021.103117

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  • イノツズマブによる再寛解導入に引き続いてブリナツモマブを投与し再移植できたB-ALLの1例

    米澤 穂高, 布施 香子, 水戸部 正樹, 武田 るい, 諏訪部 達也, 片桐 隆幸, 柴崎 康彦, 瀧澤 淳, 成田 美和子, 曽根 博仁, 増子 正義

    臨床血液   62 ( 10 )   1526 - 1526   2021.10

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    Language：Japanese   Publisher：(一社)日本血液学会-東京事務局  

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  • 同種造血幹細胞移植後の慢性GVHDとしての類上皮肉芽腫および多発筋炎

    諏訪部 達也, 布施 香子, 水戸部 正樹, 武田 ルイ, 米沢 穂高, 片桐 隆幸, 河本 啓介, 牛木 隆志, 柴崎 康彦, 瀧澤 淳, 成田 美和子, 曽根 博仁, 大島 孝一, 増子 正義

    臨床血液   62 ( 6 )   675 - 675   2021.6

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  • 陰茎・陰嚢病変を合併した精巣原発DLBCL

    水戸部 正樹, 武田 ルイ, 米沢 穂高, 田村 秀, 諏訪部 達也, 片桐 隆幸, 河本 啓介, 布施 香子, 柴崎 康彦, 増子 正義, 井上 佳菜子, 三好 寛明, 大島 孝一, 曽根 博仁, 瀧澤 淳

    臨床血液   62 ( 6 )   668 - 668   2021.6

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  • GB療法施行中にHigh-grade B-cell lymphoma with MYC and BCL2 rearrangementsで再燃したFollicular lymphoma(Grade 3A)の2症例

    水戸部 正樹, 本宮 奈津子, 武田 ルイ, 米沢 穂高, 鈴木 隆晴, 諏訪部 達也, 片桐 隆幸, 河本 啓介, 布施 香子, 柴崎 康彦, 増子 正義, 井上 佳菜子, 三好 寛明, 大島 孝一, 曽根 博仁, 瀧澤 淳

    日本リンパ網内系学会会誌   61   114 - 114   2021.5

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  • WT1-specific CD8 + cytotoxic T cells with the capacity for antigen-specific expansion accumulate in the bone marrow in MDS

    Tatsuya Suwabe, Yasuhiko Shibasaki, Hiroyuki Sato, Suguru Tamura, Takayuki Katagiri, Hiroki Nemoto, Takuya Kasami, Takashi Kozakai, Ayako Nanba, Toshiki Kitajima, Kyoko Fuse, Takashi Ushiki, Hirohito Sone, Miwako Narita, Masayoshi Masuko

    International Journal of Hematology   113 ( 5 )   723 - 734   2021.5

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：(一社)日本血液学会  

    Wilms' tumor 1 (WT1) is a tumor-associated antigen and immunotherapy target in myelodysplastic syndrome (MDS). Further information is needed on the characteristics of WT1-specific CD8 + T cells to develop immunotherapeutic strategies for MDS. To clarify the frequency, distribution, and phenotype of WT1-specific CD8 + T cells, which occur innately in MDS patients, we analyzed paired peripheral blood (PB) and bone marrow (BM) samples from 39 patients with MDS or acute myeloid leukemia with myelodysplasia-related changes. The median frequency of WT1 tetramer-binding CD8 + T cells in the CD8 + T cell population was 0.11% in PB and 0.18% in BM. A further tetramer assay combined with mixed lymphocyte peptide culture (MLPC assay) was used to detect functional WT1-specific CD8 + T cells that could respond to the WT1 peptide. Functional WT1-specific CD8 + T cells were detected in BM in 61% of patients, which was significantly higher than in PB (23%, p = 0.001). The frequency of these cells estimated by the MLPC assay was tenfold higher in BM than in PB. The majority of WT1 tetramer-binding CD8 + T cells in BM had a unique phenotype with co-expression of CD39 and CXCR4. These findings will facilitate the development of novel immunotherapeutic strategies for MDS.

    DOI： 10.1007/s12185-021-03083-0

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    Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J04671&link_issn=&doc_id=20210602220016&doc_link_id=10.1007%2Fs12185-021-03083-0&url=https%3A%2F%2Fdoi.org%2F10.1007%2Fs12185-021-03083-0&type=Crossref&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00002_2.gif

  • 腎障害を有する高悪性度B細胞リンパ腫症例にDA-EPOCH-Rを施行した1例

    水戸部 正樹, 河本 啓介, 鈴木 隆晴, 米沢 穂高, 田村 秀, 諏訪部 達也, 根本 洋樹, 布施 香子, 柴崎 康彦, 増子 正義, 三好 寛明, 大島 孝一, 曽根 博仁, 瀧澤 淳

    臨床血液   62 ( 5 )   532 - 532   2021.5

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  • GB療法施行中にHigh-grade B-cell lymphoma with MYC and BCL2 rearrangementsで再燃したFollicular lymphoma(Grade 3A)の2症例

    水戸部 正樹, 本宮 奈津子, 武田 ルイ, 米沢 穂高, 鈴木 隆晴, 諏訪部 達也, 片桐 隆幸, 河本 啓介, 布施 香子, 柴崎 康彦, 増子 正義, 井上 佳菜子, 三好 寛明, 大島 孝一, 曽根 博仁, 瀧澤 淳

    日本リンパ網内系学会会誌   61   114 - 114   2021.5

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  • 腎障害を有する高悪性度B細胞リンパ腫症例にDA-EPOCH-Rを施行した1例

    水戸部 正樹, 河本 啓介, 鈴木 隆晴, 米沢 穂高, 田村 秀, 諏訪部 達也, 根本 洋樹, 布施 香子, 柴崎 康彦, 増子 正義, 三好 寛明, 大島 孝一, 曽根 博仁, 瀧澤 淳

    臨床血液   62 ( 5 )   532 - 532   2021.5

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  • DA-EPOCH-R therapy for high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements in a patient with renal dysfunction.

    Masaki Mitobe, Keisuke Kawamoto, Takaharu Suzuki, Tatsuya Suwabe, Yasuhiko Shibasaki, Masayoshi Masuko, Kanako Inoue, Hiroaki Miyoshi, Koichi Ohshima, Hirohito Sone, Jun Takizawa

    Journal of clinical and experimental hematopathology : JCEH   61 ( 1 )   42 - 47   2021.3

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    High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, also known as double-hit lymphoma, has been reported as refractory to R-CHOP therapy and requires more intensive regimens. However, intensive and safe regimens for patients with renal dysfunction are unknown. Herein, we report the successful use of DA-EPOCH-R therapy for double-hit lymphoma in a 64-year-old man with renal dysfunction. The patient had lymphoma-induced bilateral ureteral obstruction. Although renal dysfunction remained after removing the obstruction using R-CHOP therapy, we completed six cycles of DA-EPOCH-R therapy without any major adverse events. DA-EPOCH-R therapy may be a safe regimen for renal dysfunction patients.

    DOI： 10.3960/jslrt.20043

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  • The Glasgow prognostic score divides high-risk hematopoietic cell transplantation-specific comorbidity index patients into stratified subgroups in allogeneic hematopoietic cell transplantation International journal

    Yasuhiko Shibasaki, Tatsuya Suwabe, Takayuki Katagiri, Kyoko Fuse, Miwako Narita, Hirohito Sone, Masayoshi Masuko

    Annals of Hematology   99 ( 3 )   671 - 673   2020.3

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  • Patient-based prediction algorithm of relapse after allo-HSCT for acute Leukemia and its usefulness in the decision-making process using a machine learning approach International journal

    Kyoko Fuse, Shun Uemura, Suguru Tamura, Tatsuya Suwabe, Takayuki Katagiri, Tomoyuki Tanaka, Takashi Ushiki, Yasuhiko Shibasaki, Naoko Sato, Toshio Yano, Takashi Kuroha, Shigeo Hashimoto, Tatsuo Furukawa, Miwako Narita, Hirohito Sone, Masayoshi Masuko

    Cancer Medicine   8 ( 11 )   5058 - 5067   2019.9

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    Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for high-risk acute leukemia (AL), some patients still relapse. Since patients simultaneously have many prognostic factors, difficulties are associated with the construction of a patient-based prediction algorithm of relapse. The alternating decision tree (ADTree) is a successful classification method that combines decision trees with the predictive accuracy of boosting. It is a component of machine learning (ML) and has the capacity to simultaneously analyze multiple factors. Using ADTree, we attempted to construct a prediction model of leukemia relapse within 1 year of transplantation. With the model of training data (n = 148), prediction accuracy, the AUC of ROC, and the κ-statistic value were 78.4%, 0.746, and 0.508, respectively. The false positive rate (FPR) of the relapse prediction was as low as 0.134. In an evaluation of the model with validation data (n = 69), prediction accuracy, AUC, and FPR of the relapse prediction were similar at 71.0%, 0.667, and 0.216, respectively. These results suggest that the model is generalized and highly accurate. Furthermore, the output of ADTree may visualize the branch point of treatment. For example, the selection of donor types resulted in different relapse predictions. Therefore, clinicians may change treatment options by referring to the model, thereby improving outcomes. The present results indicate that ML, such as ADTree, will contribute to the decision-making process in the diversified allo-HSCT field and be useful for preventing the relapse of leukemia.

    DOI： 10.1002/cam4.2401

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  • 1,25(OH)2D3媒介性高カルシウム血症を伴う未分化大細胞リンパ腫の症例報告(Anaplastic large cell lymphoma, with 1,25(OH)2D3-mediated hypercalcemia: A case report)

    Mitobe Masaki, Kawamoto Keisuke, Suzuki Takaharu, Kiryu Maiko, Nanba Ayako, Suwabe Tatsuya, Tanaka Tomoyuki, Fuse Kyoko, Shibasaki Yasuhiko, Masuko Masayoshi, Miyoshi Hiroaki, Ohshima Koichi, Sone Hirohito, Takizawa Jun

    Journal of Clinical and Experimental Hematopathology   59 ( 1 )   22 - 28   2019.3

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    Hypercalcemia due to malignant tumors including malignant lymphomas is relatively common. Among cancer patients with hypercalcemia, humoral hypercalcemia of malignancy is the most common and accounts for about 80% of all cases with hypercalcemia. 1,25-dihydroxyvitamin D3(1,25(OH)2D3)-mediated hypercalcemia is relatively rare. Although malignant lymphoma has been also reported to cause 1,25(OH)2D3-mediated hypercalcemia, it is not known whether there is any association between 1,25(OH)2D3-mediated hypercalcemia and any specific histological type of malignant lymphoma. We herein report a case of an anaplastic large cell lymphoma (ALCL), anaplastic lymphoma kinase (ALK) -negative with 1,25(OH)2D3-mediated hypercalcemia, which has never been previously reported. An 80-year-old Japanese man was admitted to our department due to acute exacerbation of hypercalcemia. He was diagnosed with ALCL, ALK-negative. Serum 1,25(OH)2D3 level was high and seemed to be associated with the lymphoma because the serum calcium and 1,25(OH)2D3 levels improved in response to chemotherapy. Histological findings showed that many CD68 positive macrophages were observed in the microenvironment of tumor cells. Lymphoma cells or tumor microenvironmental cells may produce 1,25(OH)2D3 because several previous reports showed the source of 1,25(OH)2D3 can be either lymphoma or tumor microenvironmental cells. Moreover, because 1,25(OH)2D3-mediated hypercalcemia has been reported regardless of the specific histological type of lymphoma, tumor microenvironmental cells may be involved in this condition. However, we could not identify the source of 1,25(OH)2D3 in this case. The association between 1,25(OH)2D3 production and prognosis in malignant lymphomas is yet unknown; further studies are needed to elucidate the clinical characteristics of malignant lymphoma with 1,25(OH)2D3-mediated hypercalcemia.

    DOI： 10.3960/jslrt.18033

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    Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J04753&link_issn=&doc_id=20190404390003&doc_link_id=1390001288139541248&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390001288139541248&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif

  • Gemcitabine, dexamethasone, and cisplatin regimen as an effective salvage therapy for high-grade b-cell lymphoma with myc and bcl2 and/or bcl6 rearrangements

    Masaki Mitobe, Keisuke Kawamoto, Takaharu Suzuki, Maiko Kiryu, Suguru Tamura, Ayako Nanba, Tatsuya Suwabe, Tomoyuki Tanaka, Kyoko Fuse, Yasuhiko Shibasaki, Masayoshi Masuko, Hiroaki Miyoshi, Koichi Ohshima, Hirohito Sone, Jun Takizawa

    Internal Medicine   58 ( 4 )   575 - 580   2019.2

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    A 61-year-old woman exhibited right inguinal lymphadenopathy and right lower limb edema approximately 1 month prior to hospitalization. She was diagnosed with high grade B-cell lymphoma, and a lymph node biopsy and fluorescence in situ hybridization indicated MYC, BCL2, and BCL6 rearrangements (triple-hit lymphoma). She had progressive disease that was CD20-negative after two courses of rituximab, cyclophosphamide, doxorubicin, vincristine, methotrexate/ifosfamide, etoposide, high-dose cytarabine (R-CODOX-M/IVAC) therapy. Subsequent etoposide, prednisolone, vincristine, cyclophosphamide, doxorubicin (EPOCH) therapy was not effective. However, after two cycles of gemcitabine, dexamethasone, and cisplatin (GDP) therapy, she achieved a complete response and was able to undergo autologous peripheral blood stem cell transplantation. GDP therapy may be effective as salvage therapy for chemotherapy-resistant triple-hit lymphoma.

    DOI： 10.2169/internalmedicine.1686-18

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  • ATRA・ATO併用療法により寛解を維持している再発性治療関連急性前骨髄白血病の1例

    前田 愁一郎, 布施 香子, 諏訪部 達也, 笠見 卓哉, 河本 啓介, 田中 智之, 難波 亜矢子, 小林 弘典, 柴崎 康彦, 瀧澤 淳, 成田 美和子, 曽根 博仁, 増子 正義

    臨床血液   59 ( 11 )   2496 - 2496   2018.11

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  • 同種造血幹細胞移植における強化口腔ケアは生着後の血流感染を減少させる(Intensive oral care can reduce blood stream infection post neutrophil engraftment in allogeneic HCT)

    諏訪部 達也, 布施 香子, 勝良 剛詞, 田中 恵子, 片桐 隆幸, 田中 智之, 牛木 隆志, 柴崎 康彦, 成田 美和子, 曽根 博仁, 増子 正義

    臨床血液   59 ( 9 )   1536 - 1536   2018.9

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  • 濾胞性リンパ腫初回診断時におけるアグレッシブリンパ腫への形質転換予測(MYC copy number predicts histologic transformation of follicular lymphoma to aggressive lymphoma)

    桐生 真依子, 河本 啓介, 鈴木 隆晴, 田村 秀, 上村 駿, 海發 茜, 諏訪部 達也, 今西 明, 笠見 卓哉, 根本 洋樹, 片桐 隆幸, 田中 智之, 難波 亜矢子, 布施 香子, 柴崎 康彦, 増子 正義, 曽根 博仁, 三好 寛明, 瀬戸 加大, 大島 孝一, 瀧澤 淳

    臨床血液   59 ( 9 )   1593 - 1593   2018.9

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  • 単一施設におけるATGとPTCYを用いた半合致移植の後方視解析(Clinical analysis of haploidentical transplantation using ATG and PTCY in single institute)

    田中 智之, 上村 駿, 海發 茜, 田村 秀, 諏訪部 達也, 片桐 隆幸, 河本 啓介, 布施 香子, 牛木 隆志, 柴崎 康彦, 瀧澤 淳, 成田 美和子, 曽根 博仁, 増子 正義

    臨床血液   59 ( 9 )   1678 - 1678   2018.9

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  • 寛解期急性白血病に対する同種移植のドナーソース別入院費の比較(Hospitalization costs of allo-HCT among donor sources for acute leukemia in complete remission)

    難波 亜矢子, 柴崎 康彦, 上村 駿, 諏訪部 達也, 片桐 隆幸, 田中 智之, 布施 香子, 成田 美和子, 曽根 博仁, 増子 正義

    臨床血液   59 ( 9 )   1680 - 1680   2018.9

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  • GDP療法がtriple-hit lymphomaの救援療法として有効であった1例

    水戸部 正樹, 河本 啓介, 鈴木 隆晴, 田村 秀, 小堺 貴司, 難波 亜矢子, 諏訪部 達也, 笠見 卓哉, 田中 智之, 布施 香子, 柴崎 康彦, 増子 正義, 曽根 博仁, 大島 孝一, 瀧澤 淳

    臨床血液   59 ( 5 )   620 - 621   2018.5

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  • The Glasgow Prognostic Score as a pre-transplant risk assessment for allogeneic hematopoietic cell transplantation International journal

    Yasuhiko Shibasaki, Tatsuya Suwabe, Takayuki Katagiri, Tomoyuki Tanaka, Hironori Kobayashi, Kyoko Fuse, Takashi Ushiki, Naoko Sato, Toshio Yano, Takashi Kuroha, Shigeo Hashimoto, Miwako Narita, Tatsuo Furukawa, Hirohito Sone, Masayoshi Masuko

    Clinical Transplantation   31 ( 11 )   2017.11

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    Evaluation methods, such as scoring systems for predicting complications in advance, are necessary for determining the adaptation of allogeneic hematopoietic cell transplantation (HCT) and selecting appropriate conditioning regimens. The Hematopoietic Cell Transplantation-specific Comorbidity Index (HCT-CI), which is based on functions of main organs, is a useful tool for pre-transplant risk assessments and has been widely applied in determining treatment strategies for patients with hematological diseases. However, as allogeneic HCT is performed on patients with diverse backgrounds, another factor, which reinforces the HCT-CI, is required to evaluate pre-transplant risk assessments. The Glasgow Prognostic Score (GPS), which assesses the combined C-reactive protein and albumin, was reported to predict survival of patients with solid-organ malignancies independently of receiving chemo/radiotherapy and stages of cancer. In this study, we applied the GPS for pre-transplant risk assessments for allogeneic HCT. The GPS successfully stratified the patients into three risk groups of overall survival (OS) and non-relapse mortality (NRM). Moreover, the GPS could predict outcomes independently of the HCT-CI for OS and NRM in multivariate analysis. The GPS is considered to be a useful tool and reinforces the HCT-CI for determining adaptation of allogeneic HCT for patients with hematopoietic neoplasms.

    DOI： 10.1111/ctr.13103

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  • Successful umbilical cord blood hematopoietic stem cell transplantation in a patient with adult T-cell leukemia/lymphoma initially achieving complete remission with anti-CC chemokine receptor 4 antibody combined chemotherapy.

    Tatsuya Suwabe, Yasuhiko Shibasaki, Akane Kaihatsu, Takayuki Katagiri, Shukuko Miyakoshi, Kyoko Fuse, Hironori Kobayashi, Takashi Ushiki, Masato Moriyama, Jun Takizawa, Miwako Narita, Hirohito Sone, Masayoshi Masuko

    [Rinsho ketsueki] The Japanese journal of clinical hematology   58 ( 1 )   32 - 36   2017

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    A 62-year-old man with CHOP refractory adult T-cell leukemia/lymphoma (ATLL) received anti-CC chemokine receptor 4 antibody (mogamulizumab) combined with CHOP and achieved complete remission. At 71 days after the final administration of mogamulizumab, he received umbilical cord blood transplantation (CBT) using reduced intensity conditioning. Umbilical cord blood engraftment was confirmed on day16. Grade II acute graft-versus-host disease (GVHD) was diagnosed on day60 and was controlled by administration of methylprednisolone. There was no evidence of relapse at 9 months after CBT. Ratios of regulatory T cells in CD4 positive T cells were remarkably low during all of these periods. Since mogamulizumab reduces regulatory T cells, the frequency and severity of acute GVHD were reported to be increased in patients administered mogamulizumab before allogenic stem cell transplantation. Further experiences are needed for selecting optimal donor sources, the portability period and GVHD prophylaxis for patients using mogamulizumab before allogeneic stem cell transplantation.

    DOI： 10.11406/rinketsu.58.32

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    Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J01540&link_issn=&doc_id=20170208250007&doc_link_id=10.11406%2Frinketsu.58.32&url=https%3A%2F%2Fdoi.org%2F10.11406%2Frinketsu.58.32&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

  • A case of central diabetes insipidus associated with cardiac dysfunction. International journal

    Nobumasa Ohara, Masanori Kaneko, Tatsuya Suwabe, Tasuku Yoshie, Hiroyuki Kuwano, Katsuya Ebe, Toshio Fujita, Koichi Fuse, Kenzo Kaneko, Kyuzi Kamoi

    Clinical case reports   4 ( 12 )   1101 - 1106   2016.12

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    Central diabetes insipidus (CDI) results from a deficiency of arginine vasopressin (AVP) secretion. It is treated by replacement therapy with the synthetic AVP analogue desmopressin. To prevent heart failure in patients with CDI accompanied by cardiac dysfunction, controlling sodium and water intake is essential, using the minimum effective dose of desmopressin.

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  • HLA半合致移植を施行した最重症再生不良性貧血の1例

    宮腰 淑子, 柴崎 康彦, 諏訪部 達也, 片桐 隆幸, 小林 弘典, 布施 香子, 森山 雅人, 瀧澤 淳, 成田 美和子, 曽根 博仁, 増子 正義

    臨床血液   57 ( 11 )   2416 - 2416   2016.11

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  • 当科におけるIVLBCL 14例の臨床病理学的検討

    諏訪部 達也, 河本 啓介, 片桐 隆幸, 宮腰 淑子, 小林 弘典, 牛木 隆志, 布施 香子, 柴崎 康彦, 森山 雅人, 増子 正義, 成田 美和子, 曽根 博仁, 瀧澤 淳, 中村 直哉, 大島 孝一

    日本リンパ網内系学会会誌   56   92 - 92   2016.8

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  • 抗CCR4抗体併用化学療法により寛解が得られた後に、臍帯血移植を行ったATLLの1例

    諏訪部 達也, 柴崎 康彦, 片桐 隆幸, 宮腰 淑子, 布施 香子, 小林 弘典, 牛木 隆志, 森山 雅人, 瀧澤 淳, 成田 美和子, 曽根 博仁, 増子 正義

    臨床血液   57 ( 6 )   776 - 776   2016.6

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  • A case of progressive encephalomyelitis with rigidity and myoclonus associated with anti-GAD, anti-glycine receptor and anti-GM1 antibodies

    Yuka Koike, Tatsuya Suwabe, Takuya Konno, Yoshitaka Umeda, Mutsuo Oyake, Nobuya Fujita

    Clinical Neurology   55 ( 2 )   111 - 114   2015

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    A 62-year-old woman with one-year history of type 1 diabetes mellitus was admitted to our hospital with progressive weakness in the lower extremities and urinary dysfunction following high fever. On admission, she had rigidity and myoclonus in the upper extremities with sensory ataxia. Cerebrospinal fluid examination revealed mild pleocytosis and oligoclonal band. Glutamic acid decarboxylase (GAD) antibodies were detected at high titer in serum, but antibodies to glycine receptor (GlyR), thyroid peroxidase, mitochondrial M2, and GM1 were also detected. She was diagnosed with progressive encephalomyelitis with rigidity and myoclonus (PERM), which probably developed on the basis of polyglandular autoimmune syndromes. The clinical symptoms began to improve after initiation of intravenous high-dose methylprednisolone. Muscle weakness might be related to GM1 antibodies. This is the first report of PERM, in which GM1 antibodies were detected with GAD and GlyR antibodies.

    DOI： 10.5692/clinicalneurol.55.111

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  • 薬剤性過敏症症候群(DIHS)様症状で発症した血管免疫芽球性T細胞リンパ腫(AITL)の1例

    内田 梢太, 長谷川 瑛人, 寺尾 香菜, 武居 慎吾, 佐藤 亜美, 阿部 理一郎, 吉澤 優太, 諏訪部 達也, 瀧澤 淳, 笠井 昭男

    日本皮膚科学会雑誌   132 ( 6 )   1490 - 1490   2022.5

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  • WT1ペプチドワクチン投与後のCML患者におけるWT1特異的CTLの持続性と多様性(Persistence and diversity of WT1-specific CTLs in a CML patient vaccinated WT1 peptide)

    諏訪部 達也, 柴崎 康彦, 田村 秀, 片桐 隆幸, 布施 香子, 牛木 隆志, 曽根 博仁, 成田 美和子, 増子 正義

    日本血液学会学術集会   83回   PS - 1   2021.9

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  • ドナーリンパ球のコンドロイチン硫酸合成低下はGVHDを軽減する(Genetic manipulation resulting in decreased donor chondroitin sulfate mitigates GVHD in mice)

    田村 秀, 牛木 隆志, 諏訪部 達也, 片桐 隆幸, 石黒 創, 布施 香子, 柴崎 康彦, 進藤 岳郎, 五十嵐 道弘, 曽根 博仁, 増子 正義

    日本血液学会学術集会   83回   OS3 - 1   2021.9

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  • AMLにおける造血幹細胞移植後1年未満の再発は高い死亡率と相関する(Post-transplant relapse of AML within one year is associated with a high mortality rate)

    片桐 隆幸, 本宮 奈津子, 武田 ルイ, 水戸部 正樹, 米沢 穂高, 諏訪部 達也, 布施 香子, 柴崎 康彦, 瀧澤 淳, 曽根 博仁, 増子 正義

    日本血液学会学術集会   83回   PS - 10   2021.9

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  • 当初薬剤性過敏症症候群と診断された血管免疫芽球性T細胞リンパ腫の1例

    内田 梢太, 長谷川 瑛人, 平山 香菜, 武居 慎吾, 佐藤 亜美, 吉澤 優太, 諏訪部 達也, 瀧澤 淳, 笠井 昭男, 阿部 理一郎

    日本皮膚科学会雑誌   131 ( 5 )   1364 - 1364   2021.5

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  • 腫瘍抗原特異的CTLがNK細胞に及ぼす影響

    相原瞳, 佐藤廣幸, 諏訪部達也, 柴崎康彦, 増子正義, 内山孝由, 佐藤英世, 富山智香子, 曽根博仁, 成田美和子

    日本免疫治療学会学術集会プログラム・抄録集   18th   2021

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  • Comparison of allo-HSCT for Primary induction failure and relapse acute myeloid leukemia

    布施香子, 武田ルイ, 水戸部正樹, 米沢穂高, 諏訪部達也, 片桐隆幸, 柴崎康彦, 曽根博仁, 増子正義

    日本造血細胞移植学会総会プログラム・抄録集   43rd   2021

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  • AML with Major & minor-bcr/abl co-expressing clone after second hematopoietic cell transplants

    本宮奈津子, 本宮奈津子, 片桐隆幸, 武田ルイ, 水戸部正樹, 米沢穂高, 諏訪部達也, 布施香子, 柴崎康彦, 瀧澤淳, 曽根博仁, 増子正義

    日本造血細胞移植学会総会プログラム・抄録集   43rd   2021

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  • Genetic Manipulation Resulting in Decreased Donor ChondroitinsulfateSynthesis Mitigates Gvhd Following Allogeneic Hematopoietic Cell Transplantation in a Murine Model

    Suguru Tamura, Takashi Ushiki, Tatsuya Suwabe, Takayuki Katagiri, Tomoyuki Tanaka, Kyoko Fuse, Yasuhiko Shibasaki, Miwako Narita, Michihiro Igarashi, Hirohito Sone, Masayoshi Masuko

    BLOOD   136   2020.11

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  • 機能的なWT1特異的CD8陽性T細胞クローンは骨髄異形成症候群の骨髄内に集積する

    諏訪部達也, 柴崎康彦, 佐藤廣幸, 田村秀, 片桐隆幸, 根本洋樹, 笠見卓哉, 小堺貴司, 難波亜矢子, 北嶋俊樹, 布施香子, 牛木隆志, 曽根博仁, 成田美和子, 増子正義

    日本血液学会学術集会抄録(Web)   82nd   2020

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  • SOCS3 Deficiency on a High-Fat Diet Accelerates Systemic Inflammation and Results in Lethal Myeloid Hematopoiesis without Obesity and Adiposity

    Kaori Cho, Takashi Ushiki, Hajime Ishiguro, Takayuki Katagiri, Tatsuya Suwabe, Hideyo Hirai, Yoshimi Nakagawa, Masayoshi Masuko, Warren Alexander, Hitoshi Shimano, Hirohito Sone

    DIABETES   68   2019.6

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    DOI： 10.2337/db19-1910-P

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  • 3度目の同種造血細胞移植後ポナチニブ維持療法を行い,寛解を維持している再発・難治Ph陽性ALL

    海發茜, 柴崎康彦, 諏訪部達也, 笠見卓哉, 田村秀, 片桐隆幸, 河本啓介, 難波亜矢子, 布施香子, 牛木隆志, 森山雅人, 瀧澤淳, 成田美和子, 曽根博仁, 増子正義

    日本造血細胞移植学会総会プログラム・抄録集   41st   2019

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  • 同種造血幹細胞移植後に再発した急性白血病の全生存とTRMの予後因子の検討

    布施香子, 諏訪部達也, 片桐隆幸, 柴崎康彦, 成田美和子, 曽根博仁, 増子正義

    日本造血細胞移植学会総会プログラム・抄録集   41st   2019

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  • Marker Chromosomes Are a New Cytogenetic Adverse Risk Factor in AML after Allo-HCT

    Kyoko Fuse, Tomoyuki Tanaka, Shun Uemura, Tatsuya Suwabe, Takayuki Katagiri, Takashi Ushiki, Yasuhiko Shibasaki, Naoko Sato, Toshio Yano, Takashi Kuroha, Shigeo Hashimoto, Tastuo Furukawa, Miwako Narita, Hirohito Sone, Masayoshi Masuko

    BLOOD   132   2018.11

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  • Clinical Features and Risk Factors of Post-Engraftment Bloodstream Infection in Allogeneic HCT

    Tatsuya Suwabe, Kyoko Fuse, Takayuki Katagiri, Tomoyuki Tanaka, Takashi Ushiki, Yasuhiko Shibasaki, Miwako Narita, Hirohito Sone, Masayoshi Masuko

    BLOOD   132   2018.11

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  • Distinct Effects of Chondroitin Sulfate on Hematopoietic Cells and the Stromal Microenvironment in Bone Marrow Hematopoiesis

    Takayuki Katagiri, Takashi Ushiki, Asami Kawasaki, Shun Uemura, Tatsuya Suwabe, Tomoyuki Tanaka, Kyoko Fuse, Yasuhiko Shibasaki, Hirohito Sone, Michihiro Igarashi, Masayoshi Masuko

    BLOOD   132   2018.11

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  • Refinement of the Glasgow Prognostic Score as a pre-transplant risk assessment for allogeneic hematopoietic cell transplantation

    Yasuhiko Shibasaki, Tatsuya Suwabe, Takayuki Katagiri, Tomoyuki Tanaka, Takashi Ushiki, Kyoko Fuse, Naoko Sato, Toshio Yano, Takashi Kuroha, Shigeo Hashimoto, Miwako Narita, Tatsuo Furukawa, Hirohito Sone, Masayoshi Masuko

    International Journal of Hematology   108 ( 3 )   282 - 289   2018.9

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    同種造血細胞移植(HCT)の移植前リスク評価に用いられるGlasgow予後予測スコア(GPS)に改良を加え、その有用性について検討した。同種HCTを施行された血液疾患患者205例(中央値46歳)を対象とした。HCT特異的GPS(HCT-GPS)の評価に際して、CRP上昇(1mg/dL超)、低アルブミン血症(3.5g/dL未満)の両者を満たす場合は2点、いずれかを呈する場合は1点、いずれも認めない場合は0点とし、さらに血清中フェリチン1000ng/mL超を呈する場合には+1点とした。検討の結果、移植前の血清フェリチン中央値は954ng/mL、アルブミン中央値は4.1g/dL、CRP中央値は0.14mg/dLであり、HCT-GPSスコアは0点が95例、1点が75例、2点が19例、3点が16例であった。一方、オリジナルのGPSスコアでは0点が158例、1点が28例、2点が19例であった。C統計量分析では非再燃死亡率(NRM)と全生存率(OS)はHCT-GPSスコアの方がGPSスコアより高値であったが有意差は認められなかった。一方、net reclassification indexesとintegrated discrimination improvementを用いた解析では有意差がみられた。また、多変量解析ではHCT-GPSスコアの1点増分はOSとNRMの不良を示す独立予測因子であることが示された。今回作成したHCT-GPSスコアは同種HCT後の早期合併症の予測に有用なツールに成りうると思われた。

    DOI： 10.1007/s12185-018-2463-x

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    Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J04671&link_issn=&doc_id=20181129310007&doc_link_id=10.1007%2Fs12185-018-2463-x&url=https%3A%2F%2Fdoi.org%2F10.1007%2Fs12185-018-2463-x&type=Crossref&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00002_2.gif

  • 寛解期急性白血病に対する同種移植のドナーソース別入院費の比較(Hospitalization costs of allo-HCT among donor sources for acute leukemia in complete remission)

    難波 亜矢子, 柴崎 康彦, 上村 駿, 諏訪部 達也, 片桐 隆幸, 田中 智之, 布施 香子, 成田 美和子, 曽根 博仁, 増子 正義

    臨床血液   59 ( 9 )   1680 - 1680   2018.9

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  • 濾胞性リンパ腫初回診断時におけるアグレッシブリンパ腫への形質転換予測(MYC copy number predicts histologic transformation of follicular lymphoma to aggressive lymphoma)

    桐生 真依子, 河本 啓介, 鈴木 隆晴, 田村 秀, 上村 駿, 海發 茜, 諏訪部 達也, 今西 明, 笠見 卓哉, 根本 洋樹, 片桐 隆幸, 田中 智之, 難波 亜矢子, 布施 香子, 柴崎 康彦, 増子 正義, 曽根 博仁, 三好 寛明, 瀬戸 加大, 大島 孝一, 瀧澤 淳

    臨床血液   59 ( 9 )   1593 - 1593   2018.9

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  • 単一施設におけるATGとPTCYを用いた半合致移植の後方視解析(Clinical analysis of haploidentical transplantation using ATG and PTCY in single institute)

    田中 智之, 上村 駿, 海發 茜, 田村 秀, 諏訪部 達也, 片桐 隆幸, 河本 啓介, 布施 香子, 牛木 隆志, 柴崎 康彦, 瀧澤 淳, 成田 美和子, 曽根 博仁, 増子 正義

    臨床血液   59 ( 9 )   1678 - 1678   2018.9

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  • GDP療法がtriple-hit lymphomaの救援療法として有効であった1例

    水戸部 正樹, 河本 啓介, 鈴木 隆晴, 田村 秀, 小堺 貴司, 難波 亜矢子, 諏訪部 達也, 笠見 卓哉, 田中 智之, 布施 香子, 柴崎 康彦, 増子 正義, 曽根 博仁, 大島 孝一, 瀧澤 淳

    臨床血液   59 ( 5 )   620 - 621   2018.5

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  • WT1ペプチドワクチン施行例における長期残存WT1-tetramer陽性細胞の機能解析及び増幅

    後藤若奈, 小川彩空, 増子正義, 諏訪部達也, 田中智之, 内山孝由, 橋本誠雄, 柴崎康彦, 高橋益廣, 成田美和子

    日本免疫治療学研究会学術集会プログラム・抄録集   15th   2018

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  • Further Prognostic Factors for Stratification of Patients in the High-Risk HCT-CI Group Undergoing Allogeneic HCT

    Yasuhiko Shibasaki, Tatsuya Suwabe, Shun Uemura, Takayuki Katagiri, Tomoyuki Tanaka, Takashi Ushiki, Kyoko Fuse, Miwako Narita, Hirohito Sone, Masayoshi Masuko

    BLOOD   130   2017.12

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  • Patient-Based Prediction Algorithm of Relapse after Allo-HSCT for Acute Leukemia Using Machine Learning Approach

    Kyoko Fuse, Shun Uemura, Tatsuya Suwabe, Takayuki Katagiri, Tomoyuki Tanaka, Takashi Ushiki, Yasuhiko Shibasaki, Naoko Sato, Toshio Yano, Takashi Kuroha, Shigeo Hashimoto, Tastuo Furukawa, Miwako Narita, Hirohito Sone, Masayoshi Masuko

    BLOOD   130   2017.12

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  • 移植前予後予測モデルとしての同種造血細胞移植特異的Glasgow Prognostic Score(HCT specific Glasgow Prognostic Score as a new predictive tool for pre-transplant risk assessments)

    Shibasaki Yasuhiko, Suwabe Tatsuya, Katagiri Takayuki, Tanaka Tomoyuki, Kobayashi Hironori, Fuse Kyoko, Ushiki Takashi, Narita Miwako, Sone Hirohito, Masuko Masayoshi

    臨床血液   58 ( 9 )   1547 - 1547   2017.9

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  • 機械学習を用いた急性白血病における造血幹細胞移植後の患者ベースの再発予測モデルと個別化治療への応用

    布施香子, 上村駿, 諏訪部達也, 片桐隆幸, 笠見卓哉, 田中智之, 難波亜矢子, 牛木隆志, 柴崎康彦, 柴崎康彦, 佐藤直子, 矢野敏雄, 黒羽高志, 橋本誠雄, 古川達雄, 成田美和子, 曽根博仁, 増子正義

    日本造血細胞移植学会総会プログラム・抄録集   40th   2017

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  • マーカー染色体が急性骨髄性白血病に対する同種造血細胞移植成績に与える影響

    田中智之, 布施香子, 諏訪部達也, 笠見卓哉, 河本啓介, 河本啓介, 牛木隆志, 森山雅人, 柴崎康彦, 柴崎康彦, 瀧澤淳, 成田美和子, 曽根博仁, 増子正義, 増子正義

    日本造血細胞移植学会総会プログラム・抄録集   40th   2017

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  • 多職種連携チーム医療が著効した食道慢性GVHDの一例

    難波亜矢子, 上村駿, 諏訪部達也, 笠見卓哉, 河本啓介, 河本啓介, 田中智之, 小林弘典, 布施香子, 小師優子, 真柄仁, 高昌良, 冨永顕太郎, 橋本哲, 横山純二, 柴崎康彦, 柴崎康彦, 瀧澤淳, 曽根博仁, 増子正義

    日本造血細胞移植学会総会プログラム・抄録集   40th   2017

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  • HLA半合致移植を施行した最重症再生不良性貧血の1例

    宮腰 淑子, 柴崎 康彦, 諏訪部 達也, 片桐 隆幸, 小林 弘典, 布施 香子, 森山 雅人, 瀧澤 淳, 成田 美和子, 曽根 博仁, 増子 正義

    臨床血液   57 ( 11 )   2416 - 2416   2016.11

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  • 寛解導入療法中に劇症型Bacillus cereus敗血症により急激な経過を辿ったT細胞性急性リンパ性白血病の1例

    諏訪部 達也, 小松 優, 笠見 卓也, 野本 信彦

    新潟県立新発田病院医誌   22 ( 1 )   16 - 19   2016.11

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    症例は36歳男性。T細胞性急性リンパ性白血病に対して、プレドニゾロンによる先行治療後に寛解導入療法を開始した。寛解導入療法4日目より胃部不快感が出現したが、発熱やCRPの上昇を認めず経過観察が行われた。11日目の未明に突然の心窩部痛を発症し、同日に死亡された。急変時の血液検査では高度の肝機能障害と溶血を伴う貧血の進行をみとめ、さらに末梢血塗抹標本で棍棒状の細菌を多数認めた。同細菌は後日Bacillus cereusと判明し、経過から劇症型Bacillus cereus敗血症と診断した。急性白血病の寛解導入療法中に急激な腹痛をきたした場合、劇症型Bacillus cereus敗血症も鑑別に入れ、抗MRSA薬を含む抗生剤投与を早急に検討すべきであると考える。(著者抄録)

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  • 重鎖沈着症を合併した良性M蛋白血症(MGUS)の一例

    笠見 卓哉, 諏訪部 達也, 野本 信彦, 中村 元

    新潟県立新発田病院医誌   22 ( 1 )   13 - 15   2016.11

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    我々はheavy chain deposition disease(HCDD)を合併したmonoclonal gam mopathy of undetermined significance(MGUS)の一例を経験したので報告する。症例は69歳、女性。尿蛋白陽性で腎生検にてHCDDの診断となり、またM蛋白を認めMGUSを合併していると診断し、新規薬剤による治療を開始した。(著者抄録)

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  • 輸血依存患者における肝臓内鉄含有量を評価するための二重エネルギーCTの重要性(Significance of dual-energy CT to evaluate liver iron content in transfusion-dependent patients)

    Kobayashi Hironori, Yoshimura Norihiko, Suwabe Tatsuya, Katagiri Takayuki, Miyakoshi Shukuko, Ushiki Takashi, Fuse Kyoko, Shibasaki Yasuhiko, Moriyama Masato, Takizawa Jun, Narita Miwako, Sone Hirohito, Masuko Masayoshi

    臨床血液   57 ( 9 )   1524 - 1524   2016.9

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  • PCNSL寛解後12年を経て発症した副鼻腔DLBCLで、繰り返す皮膚再発に対して少量経口エトポシド療法が有効であった1症例

    田村 秀, 大橋 瑠子, 梅津 哉, 諏訪部 達也, 片桐 隆幸, 河本 啓介, 宮腰 淑子, 北嶋 俊樹, 柴崎 康彦, 曽根 博仁, 青木 洋, 大島 孝一, 瀧澤 淳

    日本リンパ網内系学会会誌   56   98 - 98   2016.8

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  • THE PRE-TRANSPLANT BIOMARKER RISK INDEX BASED ON SERUM FERRITIN, ALBUMIN AND CRP CAN PREDICT OUTCOMES INDEPENDENTLY OF THE HCT-CI AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION

    T. Suwabe, Y. Shibasaki, T. Katagiri, S. Miyakoshi, H. Kobayashi, K. Fuse, T. Ushiki, N. Sato, T. Yano, T. Kuroha, S. Hashimoto, M. Narita, H. Sone, T. Furukawa, M. Masuko

    HAEMATOLOGICA   101   289 - 290   2016.6

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  • アルブミン,フェリチン,CRPを用いたBiomarker indexは,造血幹細胞移植前患者に対するHCT-CIとは独立した予後予測因子である

    諏訪部達也, 柴崎康彦, 宮腰淑子, 布施香子, 小林弘典, 牛木隆志, 森山雅人, 瀧澤淳, 成田美和子, 曽根博仁, 増子正義

    日本造血細胞移植学会総会プログラム・抄録集   38th   2016

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  • HSCT後のγ/δT細胞低値およびTreg細胞高値はいずれも再発の独立リスク因子である(Both low γ/δ T cells and high Treg cells after HSCT is an independent risk factor for relapse)

    Shibasaki Yasuhiko, Miyakoshi Syukuko, Suwabe Tatsuya, Katagiri Takayuki, Fuse Kyoko, Kobayashi Hironori, Ushiki Takashi, Moriyama Masato, Takizawa Jun, Narita Miwako, Sone Hirohito, Furukawa Tatsuo, Masuko Masayoshi

    臨床血液   56 ( 9 )   1666 - 1666   2015.9

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  • レシピエントに対する移植前評価としてのHCT-CI/年齢スコアの臨床的意義(The clinical relevance of HCT-CI/age score as pre-transplant assessment for recipients)

    Katagiri Takayuki, Shibasaki Yasuhiko, Suwabe Tatsuya, Miyakoshi Shukuko, Fuse Kyoko, Kobayashi Hironori, Ushiki Takashi, Moriyama Masato, Takizawa Jun, Narita Miwako, Sone Hirohito, Masuko Masayoshi

    臨床血液   56 ( 9 )   1665 - 1665   2015.9

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  • 抗GAD抗体、抗glycine受容体抗体、抗GM1抗体が陽性のprogressive encephalomyelitis with rigidity and myoclonusの1例

    小池 佑佳, 諏訪部 達也, 今野 卓哉, 梅田 能生, 小宅 睦郎, 藤田 信也

    臨床神経学   55 ( 2 )   111 - 114   2015.2

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    症例は1型糖尿病と診断されている62歳の女性である。発熱後、亜急性に両下肢筋力低下、尿閉をきたして入院した。頸部・上肢の筋強剛と上肢ミオクローヌス、感覚性運動失調をみとめた。血清抗GAD抗体、抗TPO抗体、抗ミトコンドリアM2抗体、抗glycine受容体抗体が陽性であり、多腺性自己免疫症候群を背景に発症した、progressive encephalomyelitis with rigidity and myoclonus(PERM)と診断した。経過中、末梢神経障害が出現し、抗GM1抗体が陽性であった。本例は多様な抗体が病態に関与し、従来のPERMの臨床像を超えた多彩な神経症状をきたした症例である。(著者抄録)

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  • 卵巣奇形腫の摘出術後に発熱・皮疹・意識障害をきたした63歳女性例

    諏訪部 達也, 今野 卓哉, 笠原 壮, 梅田 能生, 梅田 麻衣子, 小宅 睦郎, 柳沼 優子, 藤田 信也

    臨床神経学   55 ( 1 )   68 - 68   2015.1

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  • A case of conus medullaris infarction expanding to the vertebral bodies, major psoas and erector spinae muscles

    今野卓哉, 諏訪部達也, 笠原壮, 梅田能生, 小宅睦郎, 藤田信也

    臨床神経学(Web)   55 ( 9 )   661 - 4   2015

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    A 77-year-old woman presented with conus medullaris and cauda equina syndrome following a sudden pain in the bilateral lower abdomen and right buttock. Lumbar magnetic resonance imaging (MRI) showed not only a conus medullaris lesion, but also several lesions in the vertebral bodies (L1, L2), right major psoas muscle, right multifidus muscle and bilateral erector spinae muscles. As these areas receive blood supply from each branch of the same segmental artery, we considered all of the lesions as infarctions that were a result of a single parent vessel occlusion. It is known that a vertebral body lesion can be accompanied by a spinal cord infarction, but in combination with infarction of a muscle has not been reported. This is the first report of a concomitant spinal cord and muscle infarction revealed by MRI. It is noteworthy that a spinal cord infarction could expand not only to neighboring vertebral bodies, but also to muscles.

    DOI： 10.5692/clinicalneurol.cn-000729

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  • ステロイド治療が奏効した抗glycine receptor抗体陽性stiff-person syndromeの1例

    笠原 壮, 小池 佑佳, 諏訪部 達也, 今野 卓哉, 梅田 能生, 梅田 麻衣子, 小宅 睦郎, 藤田 信也

    神経治療学   31 ( 5 )   630 - 630   2014.9

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  • 多様な抗体が検出された抗グリシン受容体抗体陽性PERMの一例

    諏訪部 達也, 小池 祐佳, 今野 卓哉, 笠原 壮, 梅田 麻衣子, 梅田 能生, 小宅 睦郎, 藤田 信也

    日赤医学   66 ( 1 )   343 - 343   2014.9

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