Updated on 2024/04/30

写真a

 
SAITO Yuki
 
Organization
University Medical and Dental Hospital Dermatology Assistant Professor
Title
Assistant Professor
External link

Degree

  • 学士（医学） ( 2013.3 )

Research Interests

  • 重症薬疹

Research Areas

  • Life Science / Dermatology  / 重症薬疹

Research History

  • Niigata University   Dermatology, University Medical and Dental Hospital   Assistant Professor

    2023.4

 

Papers

  • New insights into the diagnosis and management of Stevens-Johnson syndrome and toxic epidermal necrolysis. International journal

    Yuki Saito, Riichiro Abe

    Current opinion in allergy and clinical immunology   23 ( 4 )   271 - 278   2023.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE OF REVIEW: Recent studies have been clarifying the pathogenesis and early diagnostic markers of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Additionally, the efficacy of tumor necrosis factor alpha inhibitors is attracting attention. This review provides) recent evidence for the diagnosis and management of SJS/TEN. RECENT FINDINGS: Risk factors for the development of SJS/TEN have been identified, particularly the association between HLA and the onset of SJS/TEN with specific drugs, which has been intensively studied. Research on the pathogenesis of keratinocyte cell death in SJS/TEN has also progressed, revealing the involvement of necroptosis, an inflammatory cell death, in addition to apoptosis. Diagnostic biomarkers associated with these studies have also been identified. SUMMARY: The pathogenesis of SJS/TEN remains unclear and effective therapeutic agents have not yet been established. As the involvement of innate immunity, such as monocytes and neutrophils, in addition to T cells, has become clear, a more complex pathogenesis is predicted. Further elucidation of the pathogenesis of SJS/TEN is expected to lead to the development of new diagnostic and therapeutic agents.

    DOI： 10.1097/ACI.0000000000000914

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  • Massive perianal skin ulcer due to long-standing amoebic infection in an HIV-negative, heterosexual man. International journal

    Jin Sasaki, Hiroki Fujikawa, Tatsuya Katsumi, Yuki Saito, Akihiko Yuki, Hitoshi Kameyama, Masato Nakano, Yoshifumi Shimada, Toshifumi Wakai, Riichiro Abe

    The Journal of dermatology   48 ( 4 )   e198-e200   2021.4

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  • Risk factors for lymph node metastasis in cutaneous squamous cell carcinoma: a long-term retrospective study of Japanese patients.

    Yuki Saito, Hiroki Fujikawa, Sumiko Takatsuka, Riichiro Abe, Tatsuya Takenouchi

    International journal of clinical oncology   26 ( 3 )   606 - 612   2021.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Cutaneous squamous cell carcinoma (CSCC) is one of the most common skin cancers. Prognosis is favorable following surgical resection of early-stage disease, but the management of the metastatic disease is challenging. Several prognostic risk factors have been described in the American Joint Committee on Cancer/the Union for International Cancer Control (UICC) 8th edition staging and the Brigham and Women's Hospital T classification system. However, their clinical validity in Asian populations is unclear because of racial differences in the clinical characteristics of CSCC. This study aimed to identify factors that could predict lymph node metastasis in Asian patients. METHODS: This retrospective single-center study evaluated 540 patients with primary CSCC between 1989 and 2013. Five factors were evaluated for their ability to predict lymph node metastasis: maximum tumor diameter, tumor thickness, depth of invasion, degree of differentiation, and infiltrative growth pattern (INF). RESULTS: Tumor diameter > 2 cm (p < 0.0001), tumor thickness > 6 mm (p < 0.0001), invasion beyond the subcutaneous fat (p < 0.0001), poor differentiation (p = 0.042), and INFc infiltration (p < 0.0001) were associated with lymph node metastasis in the univariate analyses. In the multivariate analysis, lymph node metastasis was independently associated with tumor size > 2 cm [hazard ratio (HR) 2.9, 95% confidence interval (CI) 1.4-6.2; p = 0.006], tumor thickness > 6.0 mm (HR 2.9, 95% CI 1.3-6.4; p = 0.007), and invasion beyond the subcutaneous fat (HR 2.3, 95% CI 1.0-5.1; p = 0.045). CONCLUSION: Larger tumor diameter, greater tumor thickness, and deeper invasion included in the UICC T classification system are associated with increased risks of lymph node metastasis from CSCC in Japanese patients.

    DOI： 10.1007/s10147-020-01830-7

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  • [PATHOGENESIS OF SEVERE CUTANEOUS ADVERSE REACTIONS: NECROPTOSIS IN STEVENS-JOHNSON SYNDROME/TOXIC EPIDERMAL NECROLYSIS].

    Yuki Saito, Akito Hasegawa, Riichiro Abe

    Arerugi = [Allergy]   70 ( 4 )   282 - 288   2021

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.15036/arerugi.70.282

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  • Cutaneous angiosarcoma: Efficacy and treatment regimen of paclitaxel maintenance therapy. International journal

    Yuki Saito, Rei Yokoyama, Yukie Umemori

    Dermatologic therapy   33 ( 4 )   e13563   2020.7

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    Language：English  

    DOI： 10.1111/dth.13563

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  • Tufted angioma associated with hyperplasia of eccrine sweat glands. International journal

    Y Saito, Y Shimomura, R Abe

    Clinical and experimental dermatology   42 ( 5 )   548 - 550   2017.7

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    Language：English  

    DOI： 10.1111/ced.13122

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  • Segmental lichen aureus in infancy. International journal

    Y Saito, Y Shimomura, M Orime, N Kariya, R Abe

    Clinical and experimental dermatology   42 ( 2 )   215 - 217   2017.3

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    Language：English  

    DOI： 10.1111/ced.13019

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