Updated on 2025/08/08

写真a

 
SAITO Yuki
 
Organization
Academic Assembly Institute of Medicine and Dentistry IGAKU KEIRETU Assistant Professor
Graduate School of Medical and Dental Sciences Molecular and Cellular Medicine Cellular Function Assistant Professor
Title
Assistant Professor
External link

Degree

  • 学士（医学） ( 2013.3 )

Research Interests

  • 重症薬疹

Research Areas

  • Life Science / Dermatology  / 重症薬疹, 皮膚悪性腫瘍

Research History (researchmap)

  • Niigata University   Medical and Dental Hospital, Dermatology   Assistant Professor

    2023.4

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Research History

  • Niigata University   Cellular Function, Molecular and Cellular Medicine, Graduate School of Medical and Dental Sciences   Assistant Professor

    2025.4

  • Niigata University   Institute of Medicine and Dentistry, Academic Assembly   Assistant Professor

    2025.4

  • Niigata University   Dermatology, University Medical and Dental Hospital   Assistant Professor

    2023.4 - 2025.3

Professional Memberships

 

Papers

  • Advancements in Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis Treatment: Utilizing Fas–FasL Inhibition to Target Cell Death Signaling Pathways for Practical Human Application

    Yuki Saito, Roberta Lotti, Haruna Kimura, Akito Hasegawa, Brydon Bennett, Antonino Amato, Carlo Pincelli, Riichiro Abe

    Journal of Investigative Dermatology   145 ( 4 )   962 - 965.e4   2025.4

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.jid.2024.08.028

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  • P2X7R-primed keratinocytes are susceptible to apoptosis via GPCR-Gβγ-pERK signal pathways

    Tomoki Nishiguchi, Haruna Kimura, Yuki Saito, Takeaki Ozawa, Riichiro Abe, Akito Hasegawa

    Journal of Dermatological Science   116 ( 3 )   90 - 99   2024.12

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.jdermsci.2024.10.001

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  • Spatial proteomics identifies JAKi as treatment for a lethal skin disease

    Thierry M. Nordmann, Holly Anderton, Akito Hasegawa, Lisa Schweizer, Peng Zhang, Pia-Charlotte Stadler, Ankit Sinha, Andreas Metousis, Florian A. Rosenberger, Maximilian Zwiebel, Takashi K. Satoh, Florian Anzengruber, Maximilian T. Strauss, Maria C. Tanzer, Yuki Saito, Ting Gong, Marvin Thielert, Haruna Kimura, Natasha Silke, Edwin H. Rodriguez, Gaetana Restivo, Hong Ha Nguyen, Annette Gross, Laurence Feldmeyer, Lukas Joerg, Mitchell P. Levesque, Peter J. Murray, Saskia Ingen-Housz-Oro, Andreas Mund, Riichiro Abe, John Silke, Chao Ji, Lars E. French, Matthias Mann

    Nature   635 ( 8040 )   1001 - 1009   2024.10

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Toxic epidermal necrolysis (TEN) is a fatal drug-induced skin reaction triggered by common medications and is an emerging public health issue<sup>1–3</sup>. Patients with TEN undergo severe and sudden epidermal detachment caused by keratinocyte cell death. Although molecular mechanisms that drive keratinocyte cell death have been proposed, the main drivers remain unknown, and there is no effective therapy for TEN<sup>4–6</sup>. Here, to systematically map molecular changes that are associated with TEN and identify potential druggable targets, we utilized deep visual proteomics, which provides single-cell-based, cell-type-resolution proteomics<sup>7,8</sup>. We analysed formalin-fixed, paraffin-embedded archived skin tissue biopsies of three types of cutaneous drug reactions with varying severity and quantified more than 5,000 proteins in keratinocytes and skin-infiltrating immune cells. This revealed a marked enrichment of type I and type II interferon signatures in the immune cell and keratinocyte compartment of patients with TEN, as well as phosphorylated STAT1 activation. Targeted inhibition with the pan-JAK inhibitor tofacitinib in vitro reduced keratinocyte-directed cytotoxicity. In vivo oral administration of tofacitinib, baricitinib or the JAK1-specific inhibitors abrocitinib or upadacitinib ameliorated clinical and histological disease severity in two distinct mouse models of TEN. Crucially, treatment with JAK inhibitors (JAKi) was safe and associated with rapid cutaneous re-epithelialization and recovery in seven patients with TEN. This study uncovers the JAK/STAT and interferon signalling pathways as key pathogenic drivers of TEN and demonstrates the potential of targeted JAKi as a curative therapy.

    DOI： 10.1038/s41586-024-08061-0

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    Other Link： https://www.nature.com/articles/s41586-024-08061-0

  • New insights into the diagnosis and management of Stevens-Johnson syndrome and toxic epidermal necrolysis. International journal

    Yuki Saito, Riichiro Abe

    Current opinion in allergy and clinical immunology   23 ( 4 )   271 - 278   2023.8

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE OF REVIEW: Recent studies have been clarifying the pathogenesis and early diagnostic markers of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Additionally, the efficacy of tumor necrosis factor alpha inhibitors is attracting attention. This review provides) recent evidence for the diagnosis and management of SJS/TEN. RECENT FINDINGS: Risk factors for the development of SJS/TEN have been identified, particularly the association between HLA and the onset of SJS/TEN with specific drugs, which has been intensively studied. Research on the pathogenesis of keratinocyte cell death in SJS/TEN has also progressed, revealing the involvement of necroptosis, an inflammatory cell death, in addition to apoptosis. Diagnostic biomarkers associated with these studies have also been identified. SUMMARY: The pathogenesis of SJS/TEN remains unclear and effective therapeutic agents have not yet been established. As the involvement of innate immunity, such as monocytes and neutrophils, in addition to T cells, has become clear, a more complex pathogenesis is predicted. Further elucidation of the pathogenesis of SJS/TEN is expected to lead to the development of new diagnostic and therapeutic agents.

    DOI： 10.1097/ACI.0000000000000914

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  • Massive perianal skin ulcer due to long-standing amoebic infection in an HIV-negative, heterosexual man. International journal

    Jin Sasaki, Hiroki Fujikawa, Tatsuya Katsumi, Yuki Saito, Akihiko Yuki, Hitoshi Kameyama, Masato Nakano, Yoshifumi Shimada, Toshifumi Wakai, Riichiro Abe

    The Journal of dermatology   48 ( 4 )   e198-e200   2021.4

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  • Risk factors for lymph node metastasis in cutaneous squamous cell carcinoma: a long-term retrospective study of Japanese patients.

    Yuki Saito, Hiroki Fujikawa, Sumiko Takatsuka, Riichiro Abe, Tatsuya Takenouchi

    International journal of clinical oncology   26 ( 3 )   606 - 612   2021.3

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Cutaneous squamous cell carcinoma (CSCC) is one of the most common skin cancers. Prognosis is favorable following surgical resection of early-stage disease, but the management of the metastatic disease is challenging. Several prognostic risk factors have been described in the American Joint Committee on Cancer/the Union for International Cancer Control (UICC) 8th edition staging and the Brigham and Women's Hospital T classification system. However, their clinical validity in Asian populations is unclear because of racial differences in the clinical characteristics of CSCC. This study aimed to identify factors that could predict lymph node metastasis in Asian patients. METHODS: This retrospective single-center study evaluated 540 patients with primary CSCC between 1989 and 2013. Five factors were evaluated for their ability to predict lymph node metastasis: maximum tumor diameter, tumor thickness, depth of invasion, degree of differentiation, and infiltrative growth pattern (INF). RESULTS: Tumor diameter > 2 cm (p < 0.0001), tumor thickness > 6 mm (p < 0.0001), invasion beyond the subcutaneous fat (p < 0.0001), poor differentiation (p = 0.042), and INFc infiltration (p < 0.0001) were associated with lymph node metastasis in the univariate analyses. In the multivariate analysis, lymph node metastasis was independently associated with tumor size > 2 cm [hazard ratio (HR) 2.9, 95% confidence interval (CI) 1.4-6.2; p = 0.006], tumor thickness > 6.0 mm (HR 2.9, 95% CI 1.3-6.4; p = 0.007), and invasion beyond the subcutaneous fat (HR 2.3, 95% CI 1.0-5.1; p = 0.045). CONCLUSION: Larger tumor diameter, greater tumor thickness, and deeper invasion included in the UICC T classification system are associated with increased risks of lymph node metastasis from CSCC in Japanese patients.

    DOI： 10.1007/s10147-020-01830-7

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  • [PATHOGENESIS OF SEVERE CUTANEOUS ADVERSE REACTIONS: NECROPTOSIS IN STEVENS-JOHNSON SYNDROME/TOXIC EPIDERMAL NECROLYSIS].

    Yuki Saito, Akito Hasegawa, Riichiro Abe

    Arerugi = [Allergy]   70 ( 4 )   282 - 288   2021

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    Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.15036/arerugi.70.282

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  • Cutaneous angiosarcoma: Efficacy and treatment regimen of paclitaxel maintenance therapy. International journal

    Yuki Saito, Rei Yokoyama, Yukie Umemori

    Dermatologic therapy   33 ( 4 )   e13563   2020.7

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    Authorship：Lead author   Language：English  

    DOI： 10.1111/dth.13563

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  • Tufted angioma associated with hyperplasia of eccrine sweat glands. International journal

    Y Saito, Y Shimomura, R Abe

    Clinical and experimental dermatology   42 ( 5 )   548 - 550   2017.7

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    Authorship：Lead author   Language：English  

    DOI： 10.1111/ced.13122

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  • Segmental lichen aureus in infancy. International journal

    Y Saito, Y Shimomura, M Orime, N Kariya, R Abe

    Clinical and experimental dermatology   42 ( 2 )   215 - 217   2017.3

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    Authorship：Lead author   Language：English  

    DOI： 10.1111/ced.13019

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MISC

Awards

  • 新潟大学塚田医学奨学金

    2025.7   スティーヴンス・ジョンソン症候群/中毒性表皮壊死症におけるPANoptosisの病態解明と治療標的の探索

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  • Imrich Sarkany Non-European Memorial Scholarship

    2025.5   European Academy of Dermatology and Venereology  

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  • 日本皮膚科学会基礎医学研究費 （資生堂寄付）

    2025.5   日本皮膚科学会   スティーヴンス・ジョンソン症候群/中毒性表皮壊死症におけるPANoptosisの病態解明と治療標的の探索

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Research Projects

  • Elucidating the PANoptosis Pathway in the Pathogenesis of Severe Cutaneous Adverse Reactions

    Grant number：25K19523

    2025.4 - 2027.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Early-Career Scientists

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

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