Updated on 2025/02/10

写真a

 
ROSENKRANZ ANDREA LYNN
 
Organization
Academic Assembly Institute of Medicine and Dentistry SHIGAKU KEIRETU Assistant Professor
Graduate School of Medical and Dental Sciences Assistant Professor
Faculty of Dentistry Department of Dentistry Assistant Professor
Graduate School of Medical and Dental Sciences Research Center for Advanced Oral Science Assistant Professor
Title
Assistant Professor
External link

Degree

  • Molecular and Cell Biology and Genetics/ PhD ( 2022.12 )

  • Molecular and Cell Biology and Genetics/ MS ( 2018.5 )

Research History

  • Niigata University   Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences   Assistant Professor

    2023.4

  • Niigata University   Institute of Medicine and Dentistry, Academic Assembly   Assistant Professor

    2023.4

Education

  • Drexel University College of Medicine   Molecular Biology and Biochemistry   Molecular & Cell Biology and Genetics

    2018.7 - 2023.12

    　 More details

    Country： United States

    researchmap

  • Drexel University College of Medicine   Molecular Biology and Biochemistry   Molecular & Cell Biology and Genetics

    2016.7 - 2018.5

    　 More details

    Country： United States

    researchmap

  • University of Delaware   Biological Sciences   Biological Sciences

    2008.8 - 2011.1

    　 More details

    Country： United States

    researchmap

 

Papers

  • A novel macrolide-Del-1 axis to regenerate bone in old age. International journal

    Kridtapat Sirisereephap, Hikaru Tamura, Jong-Hyung Lim, Meircurius Dwi Condro Surboyo, Toshihito Isono, Takumi Hiyoshi, Andrea L Rosenkranz, Yurie Sato-Yamada, Hisanori Domon, Akari Ikeda, Tomoyasu Hirose, Toshiaki Sunazuka, Nagako Yoshiba, Hiroyuki Okada, Yutaka Terao, Takeyasu Maeda, Koichi Tabeta, Triantafyllos Chavakis, George Hajishengallis, Tomoki Maekawa

    iScience   27 ( 2 )   108798 - 108798   2024.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Aging is associated with increased susceptibility to chronic inflammatory bone loss disorders, such as periodontitis, in large part due to the impaired regenerative potential of aging tissues. DEL-1 exerts osteogenic activity and promotes bone regeneration. However, DEL-1 expression declines with age. Here we show that systemically administered macrolide antibiotics and a non-antibiotic erythromycin derivative, EM-523, restore DEL-1 expression in 18-month-old ("aged") mice while promoting regeneration of bone lost due to naturally occurring age-related periodontitis. These compounds failed to induce bone regeneration in age-matched DEL-1-deficient mice. Consequently, these drugs promoted DEL-1-dependent functions, including alkaline phosphatase activity and osteogenic gene expression in the periodontal tissue while inhibiting osteoclastogenesis, leading to net bone growth. Macrolide-treated aged mice exhibited increased skeletal bone mass, suggesting that this treatment may be pertinent to systemic bone loss disorders. In conclusion, we identified a macrolide-DEL-1 axis that can regenerate bone lost due to aging-related disease.

    DOI： 10.1016/j.isci.2024.108798

    PubMed

    researchmap

  • Hypoxia-inducible factor affects hepatitis B virus transcripts and genome levels as well as the expression and subcellular location of the hepatitis B virus core protein

    Nicholas J. Duchemin, Ronak Loonawat, Kyle Yeakle, Andrea Rosenkranz, Michael J. Bouchard

    Virology   586   76 - 90   2023.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier {BV}  

    DOI： 10.1016/j.virol.2023.06.013

    researchmap

Books

  • Hepatitis B and Hepatitis D Viruses

    Andrea L. Rosenkranz, Kyle C. Yeakle, Michael J. Bouchard（ Role： Joint author）

    Academic Press, Elsevier  2024  （ ISBN:9780443158124 ）

    　More details

Research Projects

  • Identification of Era Common Bacteria and Factors by Reconstruction of Oral Bacterial Flora

    Grant number：24K22180

    2024.6 - 2026.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Challenging Research (Exploratory)

    Awarding organization：Japan Society for the Promotion of Science

    　 More details

    Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）

    researchmap

 

Teaching Experience

  • コミュニケーション論II

    2024
    Institution name：新潟大学

  • 基礎分子生物学・細胞生物学・遺伝学IIB

    2024
    Institution name：新潟大学

  • 基礎分子生物学・細胞生物学・遺伝学IIA

    2024
    Institution name：新潟大学

  • 基礎分子生物学・細胞生物学・遺伝学IB

    2024
    Institution name：新潟大学

  • 基礎分子生物学・細胞生物学・遺伝学IA

    2024
    Institution name：新潟大学

  • 学問の扉 知と方法の最前線

    2024
    Institution name：新潟大学

▶ display all