Faculty Profiles - ROSENKRANZ ANDREA LYNN

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ROSENKRANZ ANDREA LYNN

Organization

Academic Assembly Institute of Medicine and Dentistry SHIGAKU KEIRETU Assistant Professor
Graduate School of Medical and Dental Sciences Assistant Professor
Faculty of Dentistry Department of Dentistry Assistant Professor
Graduate School of Medical and Dental Sciences Research Center for Advanced Oral Science Assistant Professor

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Degree

Molecular and Cell Biology and Genetics/ PhD ( 2022.12 )
Molecular and Cell Biology and Genetics/ MS ( 2018.5 )

Research History

Niigata University Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences Assistant Professor

2023.4
Niigata University Institute of Medicine and Dentistry, Academic Assembly Assistant Professor

2023.4

Education

Drexel University College of Medicine Molecular Biology and Biochemistry Molecular & Cell Biology and Genetics

2018.7 - 2023.12

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Country： United States

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Drexel University College of Medicine Molecular Biology and Biochemistry Molecular & Cell Biology and Genetics

2016.7 - 2018.5

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Country： United States

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University of Delaware Biological Sciences Biological Sciences

2008.8 - 2011.1

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Country： United States

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Papers

A novel macrolide-Del-1 axis to regenerate bone in old age. International journal

Kridtapat Sirisereephap, Hikaru Tamura, Jong-Hyung Lim, Meircurius Dwi Condro Surboyo, Toshihito Isono, Takumi Hiyoshi, Andrea L Rosenkranz, Yurie Sato-Yamada, Hisanori Domon, Akari Ikeda, Tomoyasu Hirose, Toshiaki Sunazuka, Nagako Yoshiba, Hiroyuki Okada, Yutaka Terao, Takeyasu Maeda, Koichi Tabeta, Triantafyllos Chavakis, George Hajishengallis, Tomoki Maekawa

iScience 27 ( 2 ) 108798 - 108798 2024.2

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Language：English Publishing type：Research paper (scientific journal)

Aging is associated with increased susceptibility to chronic inflammatory bone loss disorders, such as periodontitis, in large part due to the impaired regenerative potential of aging tissues. DEL-1 exerts osteogenic activity and promotes bone regeneration. However, DEL-1 expression declines with age. Here we show that systemically administered macrolide antibiotics and a non-antibiotic erythromycin derivative, EM-523, restore DEL-1 expression in 18-month-old ("aged") mice while promoting regeneration of bone lost due to naturally occurring age-related periodontitis. These compounds failed to induce bone regeneration in age-matched DEL-1-deficient mice. Consequently, these drugs promoted DEL-1-dependent functions, including alkaline phosphatase activity and osteogenic gene expression in the periodontal tissue while inhibiting osteoclastogenesis, leading to net bone growth. Macrolide-treated aged mice exhibited increased skeletal bone mass, suggesting that this treatment may be pertinent to systemic bone loss disorders. In conclusion, we identified a macrolide-DEL-1 axis that can regenerate bone lost due to aging-related disease.

DOI： 10.1016/j.isci.2024.108798

PubMed

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Hypoxia-inducible factor affects hepatitis B virus transcripts and genome levels as well as the expression and subcellular location of the hepatitis B virus core protein

Nicholas J. Duchemin, Ronak Loonawat, Kyle Yeakle, Andrea Rosenkranz, Michael J. Bouchard

Virology 586 76 - 90 2023.9

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Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier {BV}

DOI： 10.1016/j.virol.2023.06.013

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Books

Hepatitis B and Hepatitis D Viruses

Andrea L. Rosenkranz, Kyle C. Yeakle, Michael J. Bouchard（ Role： Joint author）

Academic Press, Elsevier 2024 （ ISBN:9780443158124 ）

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