2024/05/02 更新

写真a

ナガイ　タカヒロ
永井　貴大
NAGAI Takahiro
所属
医歯学総合病院 ゲノム医療部 ゲノム情報管理センター 特任助教
職名
特任助教
ホームページ
https://riss.ipa.go.jp/r?r=000816
外部リンク

学位

  • 博士（医学） （ 2023年3月   新潟大学 ）

  • 学士（医学） （ 2015年3月   新潟大学 ）

経歴

  • 新潟大学   医歯学総合病院 ゲノム医療部 ゲノム情報管理センター   特任助教

    2023年4月 - 現在

取得資格

  • 医師

 

論文

  • Clinical significance of metastatic tumor deposit foci in rectal cancer in the lateral pelvic lymph node area.

    Daisuke Yamai, Yoshifumi Shimada, Masato Nakano, Hikaru Ozeki, Akio Matsumoto, Kaoru Abe, Yosuke Tajima, Mae Nakano, Hiroshi Ichikawa, Jun Sakata, Takahiro Nagai, Yiwei Ling, Shujiro Okuda, Gen Watanabe, Hitoshi Nogami, Satoshi Maruyama, Yasumasa Takii, Toshifumi Wakai

    International journal of clinical oncology   28 ( 10 )   1388 - 1397   2023年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Although previous studies have demonstrated that tumor deposits (TDs) are associated with worse prognosis in colon cancer, their clinical significance in rectal cancer has not been fully elucidated, especially in the lateral pelvic lymph node (LPLN) area. This study aimed to clarify the clinical significance of TDs, focusing on the number of metastatic foci, including lymph node metastases (LNMs) and TDs, in the LPLN area. METHODS: This retrospective study involved 226 consecutive patients with cStage II/III low rectal cancer who underwent LPLN dissection. Metastatic foci, including LNM and TD, in the LPLN area were defined as lateral pelvic metastases (LP-M) and were evaluated according to LP-M status: presence (absence vs. presence), histopathological classification (LNM vs. TD), and number (one to three vs. four or more). We evaluated the relapse-free survival of each model and compared them using the Akaike information criterion (AIC) and Harrell's concordance index (c-index). RESULTS: Forty-nine of 226 patients (22%) had LP-M, and 15 patients (7%) had TDs. The median number of LP-M per patient was one (range, 1-9). The best risk stratification power was observed for number (AIC, 758; c-index, 0.668) compared with presence (AIC, 759; c-index, 0.665) and histopathological classification (AIC, 761; c-index, 0.664). The number of LP-M was an independent prognostic factor for both relapse-free and overall survival, and was significantly associated with cumulative local recurrence. CONCLUSION: The number of metastatic foci, including LNMs and TDs, in the LPLN area is useful for risk stratification of patients with low rectal cancer.

    DOI： 10.1007/s10147-023-02391-1

    PubMed

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  • Deep learning classification of urinary sediment crystals with optimal parameter tuning. 国際誌

    Takahiro Nagai, Osamu Onodera, Shujiro Okuda

    Scientific reports   12 ( 1 )   21178 - 21178   2022年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The examination of urinary sediment crystals, the sedimentary components of urine, is useful in screening tests, and is always performed in medical examinations. The examination of urinary sediment crystals is typically done by classifying them under a microscope. Although automated analyzers are commercially available, manual classification is required, which is time-consuming and varies depending on the technologist performing the test and the laboratory. A set of test images was created, consisting of training, validation, and test images. The training images were transformed and augmented using various methods. The test images were classified to determine the patterns that could be correctly classified. Convolutional neural networks were used for training. Furthermore, we also considered the case where the crystal subcategories were not treated as separate. Learning with all parameters except the random cropping parameter showed the highest accuracy value. Treating the subcategories together or separately did not seem to affect the accuracy value. The accuracy of the best pattern was 0.918. When matched to a real-world case, the percentage of correct answers was 88%. Although the number of images was limited, good results were obtained in the classification of crystal images with optimal parameter tuning. The parameter optimization performed in this study can be used as a reference for future studies, with the goal of image classification by deep learning in clinical practice.

    DOI： 10.1038/s41598-022-25385-x

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  • Mucin phenotype and genetic alterations in non-V600E BRAF-mutated colorectal cancer

    Hikaru Ozeki, Yoshifumi Shimada, Mae Nakano, Shuhei Kondo, Riuko Ohashi, Yamato Miwa, Daisuke Yamai, Akio Matsumoto, Kaoru Abe, Yosuke Tajima, Hiroshi Ichikawa, Jun Sakata, Yasumasa Takii, Mika Sugai, Takahiro Nagai, Yiwei Ling, Shujiro Okuda, Toshifumi Wakai

    Human Pathology   2024年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

    DOI： 10.1016/j.humpath.2024.02.009

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  • 人工知能 深層学習による画像処理技術の医療への応用

    永井 貴大, 奥田 修二郎

    新潟医学会雑誌   137 ( 2 )   39 - 45   2023年2月

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    記述言語：日本語   出版者・発行元：新潟医学会  

    脳の視覚野にヒントを得て考案された深層学習ネットワークによる画像処理技術への医療への応用が期待されている.深層学習は,コンピュータの発展による扱えるデータ量の増大によって発展し,複雑な課題を精度よくこなす技術が開発されている.しかし,深層学習の医療への応用には,データの収集の困難さをはじめとした,いくつかの問題点がある.本稿では,データの前処理で精度向上を試みた著者らの取り組みとともに,深層学習による画像処理技術の発展と今後の展望について紹介する.(著者抄録)

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  • Coexistence of Hereditary Spastic Paraplegia Type 4 and Narcolepsy: A Case Report. 国際誌

    Takahiro Nagai, Yoko Sunami, Risa Kato, Megumi Sugai, Makoto Takahara, Kentaro Ohta, Hidehiko Fujinaka, Kiyoe Goto, Osamu Okanura, Takashi Nakajima, Tetsuo Ozawa

    Case reports in neurology   13 ( 1 )   84 - 91   2021年

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    記述言語：英語  

    Spastic paraplegia type 4 (SPG4) is the most common type of hereditary spastic paraplegia (HSP) caused by the mutations in the SPAST gene, which encodes a microtubule-severing protein named spastin. Spastin regulates the number and mobility of microtubules and is essential for axonal outgrowth and neuronal morphogenesis. Herein, we report a patient with SPG4 harboring a novel donor splice site mutation in the SPAST gene (c.1616+1dupG). Although SPG4 usually manifests itself as a pure form of HSP, this patient exhibited a slow progressive cognitive decline and also developed narcolepsy type 2 (narcolepsy without cataplexy) prior to the onset of SPG4. Recently, cognitive decline has attracted attention as a main non-motor symptom of SPG4. However, this is the first reported case of a patient developing both SPG4 and narcolepsy, although it remains unclear whether the manifestation of the two diseases is a coincidence or an association. In this report, we describe the clinical symptoms and genetic background of the patient.

    DOI： 10.1159/000512404

    PubMed

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  • Role of RNF213 p.4810K variant in the development of intracranial arterial disease in patients treated with nilotinib. 国際誌

    Masahiro Uemura, Masato Kanazawa, Takuma Yamagishi, Takahiro Nagai, Mami Takahashi, Shingo Koide, Masayoshi Tada, Junsuke Shimbo, Aiko Isami, Kunihiko Makino, Masayoshi Masuko, Kouji Nikkuni, Kouichirou Okamoto, Shuichi Igarashi, Kenichi Morita, Osamu Onodera

    Journal of the neurological sciences   408   116577 - 116577   2020年1月

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  • 救急搬送される患者数とそれを診る日当直研修医との統計学的検討

    永井 貴大

    長岡赤十字病院医学雑誌   30 ( 1 )   45 - 48   2017年12月

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    記述言語：日本語   出版者・発行元：長岡赤十字病院  

    2015年12月から2016年11月迄に初期研修医10名が、休日当番日の日当直、平日当番日の当直を何回行ったか検討した。調査対象期間における当番日は124日であった。調査対象期間における休日当番日の日当直及び平日当番日の当直時間帯に来院した救急車数の合計は1710台であった。当直1回あたり救急車数は13.375～14.556台で、全研修医の当直は13.790台と推定した。

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  • Development and external validation of a nomogram for overall survival after curative resection in serosa-negative, locally advanced gastric cancer. 国際誌

    S Hirabayashi, S Kosugi, Y Isobe, A Nashimoto, I Oda, K Hayashi, I Miyashiro, S Tsujitani, Y Kodera, Y Seto, H Furukawa, H Ono, S Tanabe, M Kaminishi, S Nunobe, T Fukagawa, R Matsuo, T Nagai, H Katai, T Wakai, K Akazawa

    Annals of oncology : official journal of the European Society for Medical Oncology   25 ( 6 )   1179 - 84   2014年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Few nomograms can predict overall survival (OS) after curative resection of advanced gastric cancer (AGC), and these nomograms were developed using data from only a few large centers over a long time period. The aim of this study was to develop and externally validate an elaborative nomogram that predicts 5-year OS after curative resection for serosa-negative, locally AGC using a large amount of data from multiple centers in Japan over a short time period (2001-2003). PATIENTS AND METHODS: Of 39 859 patients who underwent surgery for gastric cancer between 2001 and 2003 at multiple centers in Japan, we retrospectively analyzed 5196 patients with serosa-negative AGC who underwent Resection A according to the 13th Japanese Classification of Gastric Carcinoma. The data of 3085 patients who underwent surgery from 2001 to 2002 were used as a training set for the construction of a nomogram and Web software. The data of 2111 patients who underwent surgery in 2003 were used as an external validation set. RESULTS: Age at operation, gender, tumor size and location, macroscopic type, histological type, depth of invasion, number of positive and examined lymph nodes, and lymphovascular invasion, but not the extent of lymphadenectomy, were associated with OS. Discrimination of the developed nomogram was superior to that of the TNM classification (concordance indices of 0.68 versus 0.61; P < 0.001). Moreover, calibration was accurate. CONCLUSIONS: We have developed and externally validated an elaborative nomogram that predicts the 5-year OS of postoperative serosa-negative AGC. This nomogram would be helpful in the assessment of individual risks and in the consideration of additional therapy in clinical practice, and we have created freely available Web software to more easily and quickly predict OS and to draw a survival curve for these purposes.

    DOI： 10.1093/annonc/mdu125

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