2025/07/06 更新

写真a

タカハシ マナミ
髙橋 真奈美
TAKAHASHI Manami
所属
教育研究院 医歯学系 特任助手
医歯学総合研究科 特任助手
職名
特任助手
外部リンク

学位

  • 博士(医学) ( 2012年3月   新潟大学 )

研究分野

  • ライフサイエンス / 腫瘍生物学

  • ライフサイエンス / ウイルス学

  • ライフサイエンス / 免疫学

経歴(researchmap)

  • 新潟大学   大学院医歯学総合研究科 地域疾病制御医学専攻 国際感染医学   特任助手

    2023年4月 - 現在

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  • 新潟大学   産学地域連携推進機構 産学地域人材育成センター   研究員

    2013年4月 - 2014年12月

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  • 東京医科歯科大学   医歯学研究支援センター   研究機関研究員

    2012年4月 - 2013年3月

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経歴

  • 新潟大学   医歯学総合研究科   特任助手

    2023年4月 - 現在

  • 新潟大学   教育研究院 医歯学系   特任助手

    2023年4月 - 現在

所属学協会

  • 日本ウイルス学会

    2025年5月 - 現在

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  • 日本癌学会

    2007年 - 現在

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論文

  • Acute type adult T-cell leukemia cells proliferate in the lymph nodes rather than in peripheral blood. 査読 国際誌

    Mariko Mizuguchi, Mitsuyoshi Takatori, Shugo Sakihama, Manami Yoshita-Takahashi, Naoki Imaizumi, Yoshiaki Takahashi, Hiroo Hasegawa, Kennosuke Karube, Takuya Fukushima, Masataka Nakamura, Yuetsu Tanaka

    Cancer gene therapy   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A massive increase in the number of mature CD4+ T-cells in peripheral blood (PB) is a defining characteristic of acute type of adult T-cell leukemia (ATL). To date, the site of proliferation of ATL cells in the body has been unclear. In an attempt to address this question, we examined the expression of the proliferation marker, Ki-67, in freshly isolated ATL cells from PB and lymph nodes (LNs) of patients with various types of ATL. Our findings reveal that LN-ATL cells display higher expression of the Ki-67 antigen than PB-ATL cells in acute type patients. The gene expression of T-cell quiescence regulators such as Krüppel-like factor 2/6 and forkhead box protein 1 was substantially high in acute type PB-ATL cells. The expression of human telomerase reverse transcriptase, which is involved in T-cell expansion, was significantly low in PB-ATL cells from acute type patients, similar to that in normal resting T-cells. These findings suggest that ATL cells proliferate in the LNs rather than in PB.

    DOI: 10.1038/s41417-022-00475-0

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  • Promoter CpG methylation inhibits Krüppel-like factor 2 (KLF2)-Mediated repression of hTERT gene expression in human T-cells 査読

    Mariko Mizuguchi, Toshifumi Hara, Manami Yoshita-Takahashi, Takashi Kohda, Yuetsu Tanaka, Masataka Nakamura

    Biochemistry and Biophysics Reports   26   100984 - 100984   2021年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.bbrep.2021.100984

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  • RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells. 査読 国際誌

    Suguru Saito, Toshihiko Kawamura, Masaya Higuchi, Takahiro Kobayashi, Manami Yoshita-Takahashi, Maya Yamazaki, Manabu Abe, Kenji Sakimura, Yasuhiro Kanda, Hiroki Kawamura, Shuying Jiang, Makoto Naito, Takumi Yoshizaki, Masahiko Takahashi, Masahiro Fujii

    European journal of immunology   45 ( 5 )   1512 - 23   2015年5月

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    記述言語:英語  

    Ras GTPase-activating proteins negatively regulate the Ras/Erk signaling pathway, thereby playing crucial roles in the proliferation, function, and development of various types of cells. In this study, we identified a novel Ras GTPase-activating proteins protein, RASAL3, which is predominantly expressed in cells of hematopoietic lineages, including NKT, B, and T cells. We established systemic RASAL3-deficient mice, and the mice exhibited a severe decrease in NKT cells in the liver at 8 weeks of age. The treatment of RASAL3-deficient mice with α-GalCer, a specific agonist for NKT cells, induced liver damage, but the level was less severe than that in RASAL3-competent mice, and the attenuated liver damage was accompanied by a reduced production of interleukin-4 and interferon-γ from NKT cells. RASAL3-deficient NKT cells treated with α-GalCer in vitro presented augmented Erk phosphorylation, suggesting that there is dysregulated Ras signaling in the NKT cells of RASAL3-deficient mice. Taken together, these results suggest that RASAL3 plays an important role in the expansion and functions of NKT cells in the liver by negatively regulating Ras/Erk signaling, and might be a therapeutic target for NKT-associated diseases.

    DOI: 10.1002/eji.201444977

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  • Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells 査読

    Takayuki Takachi, Masahiko Takahashi, Manami Takahashi-Yoshita, Masaya Higuchi, Miki Obata, Yukio Mishima, Shujiro Okuda, Yuetsu Tanaka, Masao Matsuoka, Akihiko Saitoh, Patrick L. Green, Masahiro Fujii

    Cancer Science   106 ( 4 )   461 - 465   2015年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Blackwell Publishing Ltd  

    DOI: 10.1111/cas.12618

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  • HTLV-1 Tax oncoprotein stimulates ROS production and apoptosis in T cells by interacting with USP10 査読

    Masahiko Takahashi, Masaya Higuchi, Grace Naswa Makokha, Hideaki Matsuki, Manami Yoshita, Yuetsu Tanaka, Masahiro Fujii

    Blood   122 ( 5 )   715 - 725   2013年8月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Society of Hematology  

    <title>Key Points</title>
    Interaction of HTLV-1 Tax with USP10 reduces arsenic-induced stress granule formation and enhances ROS production. USP10 controls sensitivities of leukemia cell lines to arsenic-induced apoptosis.

    DOI: 10.1182/blood-2013-03-493718

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  • Stress Granules Inhibit Apoptosis by Reducing Reactive Oxygen Species Production 査読

    Masahiko Takahashi, Masaya Higuchi, Hideaki Matsuki, Manami Yoshita, Toshiaki Ohsawa, Masayasu Oie, Masahiro Fujii

    Molecular and Cellular Biology   33 ( 4 )   815 - 829   2013年2月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Informa UK Limited  

    DOI: 10.1128/mcb.00763-12

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    その他リンク: https://www.tandfonline.com/doi/pdf/10.1128/MCB.00763-12

  • Human T cell leukemia virus type 2 (HTLV-2) Tax2 has a dominant activity over HTLV-1 Tax1 to immortalize human CD4(+) T cells 査読

    Michitaka Imai, Masaya Higuchi, Hiroki Kawamura, Manami Yoshita, Masahiko Takahashi, Masayasu Oie, Hideaki Matsuki, Yuetsu Tanaka, Yutaka Aoyagi, Masahiro Fujii

    VIRUS GENES   46 ( 1 )   39 - 46   2013年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s11262-012-0831-9

    Web of Science

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  • Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth 査読

    Manami Yoshita, Masaya Higuchi, Masahiko Takahashi, Masayasu Oie, Yuetsu Tanaka, Masahiro Fujii

    CANCER SCIENCE   103 ( 2 )   369 - 374   2012年2月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/j.1349-7006.2011.02123.x

    Web of Science

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  • Knockdown of synapse-associated protein Dlg1 reduces syncytium formation induced by human T-cell leukemia virus type 1 査読

    Sakiko Yoshida, Masaya Higuchi, Toshiyuki Shoji, Manami Yoshita, Kojiro Ishioka, Masahiko Takahashi, Masayasu Oie, Yuetsu Tanaka, Makoto Uchiyama, Masahiro Fujii

    Virus Genes   37 ( 1 )   9 - 15   2008年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s11262-008-0234-0

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