Updated on 2024/12/22

写真a

 
REZA Kuruniawan Aruta
 
Organization
Academic Assembly Institute of Medicine and Dentistry IGAKU KEIRETU Assistant Professor
Faculty of Medicine School of Medicine Assistant Professor
Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Sensory and Integrative Medicine Assistant Professor
Title
Assistant Professor
External link

Degree

  • Doctoral Degree (Ph.D.) ( 2023.9 )

Research Interests

  • high-content screening

  • Genotyping

  • Sanger Sequencing

  • primary neuron culture

  • Fragment analysis

  • Autism spectrum disorder

Research History (researchmap)

  • Hasanuddin University   Bachelor of Medicine Program Unit

    2019.1 - 2020.6

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    Country：Indonesia

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  • Hasanuddin University   Department of Anatomy   Lecturer

    2017.1 - 2020.6

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    Country：Indonesia

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Research History

  • Niigata University   Institute of Medicine and Dentistry, Academic Assembly   Assistant Professor

    2024.4

  • Niigata University   Sensory and Integrative Medicine, Biological Functions and Medical Control, Graduate School of Medical and Dental Sciences   Assistant Professor

    2024.4

  • Niigata University   School of Medicine, Faculty of Medicine   Assistant Professor

    2024.4

  • Niigata University   Institute of Medicine and Dentistry, Academic Assembly   Specially Appointed Assistant Professor

    2023.10 - 2024.3

  • Niigata University   Graduate School of Medical and Dental Sciences   Specially Appointed Assistant Professor

    2023.10 - 2024.3

Education

  • Niigata University   Graduate School of Medical and Dental Sciences   Department of Psychiatry

    2019.10 - 2023.9

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    Country： Japan

    Notes： Doctoral Degree

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  • Hasanuddin University   Faculty of Medicine

    2014.10 - 2017.6

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    Country： Indonesia

    Notes： Medical Doctor

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  • Hasanuddin University   Faculty of Medicine

    2011.7 - 2014.9

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    Country： Indonesia

    Notes： Bachelor of Medicine

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Papers

  • Effects of MAP4K inhibition on neurite outgrowth

    Di Ja Lasham, Reza K. Arta, Abdul Fuad Hadi, Jun Egawa, Vance P. Lemmon, Toshiyuki Takasugi, Michihiro Igarashi, Toshiyuki Someya

    Molecular Brain   16 ( 1 )   2023.11

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Protein kinases are responsible for protein phosphorylation and are involved in important intracellular signal transduction pathways in various cells, including neurons; however, a considerable number of poorly characterized kinases may be involved in neuronal development. Here, we considered mitogen-activated protein kinase kinase kinase kinases (MAP4Ks), related to as candidate regulators of neurite outgrowth and synaptogenesis, by examining the effects of a selective MAP4K inhibitor PF06260933. PF06260933 treatments of the cultured neurons reduced neurite lengths, not the number of synapses, and phosphorylation of GAP43 and JNK, relative to the control. These results suggest that MAP4Ks are physiologically involved in normal neuronal development and that the resultant impaired neurite outgrowth by diminished MAP4Ks’ activity, is related to psychiatric disorders.

    DOI： 10.1186/s13041-023-01066-2

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    Other Link： https://link.springer.com/article/10.1186/s13041-023-01066-2/fulltext.html

  • The cyclin G-associated kinase (GAK) inhibitor SGC-GAK-1 inhibits neurite outgrowth and synapse formation

    Jun Egawa, Reza K. Arta, Vance P. Lemmon, Melissa Muños-Barrero, Yan Shi, Michihiro Igarashi, Toshiyuki Someya

    Molecular Brain   15 ( 1 )   2022.7

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Protein kinases are responsible for protein phosphorylation and are involved in important signal transduction pathways; however, a considerable number of poorly characterized kinases may be involved in neuronal development. Here, we considered cyclin G-associated kinase (GAK) as a candidate regulator of neurite outgrowth and synaptogenesis by examining the effects of the selective GAK inhibitor SGC-GAK-1. SGC-GAK-1 treatment of cultured neurons reduced neurite length and decreased synapse number and phosphorylation of neurofilament 200-kDa subunits relative to the control. In addition, the related kinase inhibitor erlotinib, which has distinct specificity and potency from SGC-GAK-1, had no effect on neurite growth, unlike SGC-GAK-1. These results suggest that GAK may be physiologically involved in normal neuronal development, and that decreased GAK function and the resultant impaired neurite outgrowth and synaptogenesis may be related to neurodevelopmental disorders.

    DOI： 10.1186/s13041-022-00951-6

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    Other Link： https://link.springer.com/article/10.1186/s13041-022-00951-6/fulltext.html

  • Novel missense SETD1A variants in Japanese patients with schizophrenia: Resequencing and association analysis

    Ryo Morikawa, Yuichiro Watanabe, Hirofumi Igeta, Reza K. Arta, Masashi Ikeda, Satoshi Okazaki, Satoshi Hoya, Takeo Saito, Ikuo Otsuka, Jun Egawa, Takaki Tanifuji, Nakao Iwata, Toshiyuki Someya

    Psychiatry Research   310   114481 - 114481   2022.4

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.psychres.2022.114481

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  • Resequencing and association analysis of GAP43 with autism spectrum disorder and schizophrenia in a Japanese population

    Reza K. Arta, Yuichiro Watanabe, Emiko Inoue, Yoshihiro Nawa, Ryo Morikawa, Jun Egawa, Itaru Kushima, Hirofumi Igeta, Satoshi Hoya, Atsunori Sugimoto, Andi J. Tanra, Norio Ozaki, Toshiyuki Someya

    Research in Autism Spectrum Disorders   82   101729 - 101729   2021.4

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.rasd.2021.101729

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Awards

  • Young Investigator Award

    2022.10  

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