2024/10/07 更新

写真a

タムラ ツトム
田村 務
TAMURA Tsutomu
所属
教育研究院 医歯学系 特任教授
医歯学総合研究科 特任教授
職名
特任教授
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外部リンク

学位

  • 医学博士 ( 2011年3月   新潟大学 )

  • 獣医学修士 ( 1985年3月   麻布大学 )

研究キーワード

  • Viral gastroenteritis

  • Norovirus

  • ウイルス性胃腸炎

  • ノロウイルス

  • 食中毒

研究分野

  • ライフサイエンス / 獣医学

  • ライフサイエンス / ウイルス学

  • ライフサイエンス / 医療管理学、医療系社会学

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含む

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない

経歴

  • 新潟大学   教育研究院 医歯学系   特任教授

    2024年4月 - 現在

  • 新潟大学   医歯学総合研究科   特任教授

    2024年4月 - 現在

学歴

  • 新潟大学   医歯学総合研究科   国際感染医学講座公衆衛生学分野

    2007年4月 - 2011年3月

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  • 麻布大学   獣医学研究科   病理学

    - 1980年

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    国名: 日本国

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所属学協会

 

論文

  • Incidence of Omicron Variant Reinfection and Reduction of Reinfection Risk After Coronavirus Disease 2019 Vaccination in Children. 国際誌

    Tatsuki Ikuse, Yuta Aizawa, Satoshi Hasegawa, Masashi Takahashi, Takanori Hayashi, Miyako Kon, Tsutomu Tamura, Haruki Matsumoto, Akihiko Saitoh

    Journal of the Pediatric Infectious Diseases Society   2023年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Data are limited on the incidence of coronavirus disease 2019 (COVID-19) reinfection in children. This population-based cohort study in Niigata, Japan from January to November 2022 demonstrated the incidence of reinfection was 1337/48 099 (2.8%), and the hazard ratio for reinfection in vaccinated children was 0.29 (95% confidence interval, 0.20-0.40).

    DOI: 10.1093/jpids/piad093

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  • Comparison of Clinical Characteristics of Children Infected with Coronavirus Disease 2019 between Omicron Variant BA.5 and BA.1/BA.2 in Japan. 国際誌

    Tatsuki Ikuse, Yuta Aizawa, Takayuki Yamanaka, Satoshi Hasegawa, Takanori Hayashi, Miyako Kon, Tsutomu Tamura, Akihiko Saitoh

    The Pediatric infectious disease journal   2023年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has dramatically altered the clinical profile of pediatric coronavirus disease 2019 (COVID-19). In Japan, we experienced a pandemic of omicron subvariant BA.1/BA.2 from January through June 2022. However, after the emergence of BA.5 in early July 2022, the number of children hospitalized with COVID-19 increased dramatically in Japan. METHODS: We collected data on monthly numbers of cases and clinical characteristics of hospitalized children with COVID-19 in 13 hospitals, the total number of pediatric COVID-19 cases, and COVID-19 vaccination rates in Niigata, Japan, for the period from January 2020 through August 2022. We compared clinical presentation during the periods of BA.1/BA.2 predominance (January-June 2022) and BA.5 predominance (July-August 2022) and estimated vaccine effectiveness (VE) against hospitalization during the BA.5-predominant period. RESULTS: Between January 1, 2020, and August 31, 2022, 49,387 children (19,085 children/100,000 population) were newly diagnosed as having COVID-19, and 393 were hospitalized for COVID-19. Hospitalization for febrile seizure, especially complex seizure, was significantly higher during BA.5 predominance than during BA.1/BA.2 predominance (27.9% vs. 7.0%, P < 0.01). VE against hospitalization during BA.5 predominance was estimated to be 75% (95% confidence interval, 48%-88%, P < 0.01). CONCLUSIONS: The emergence of BA.5 significantly affected children in Japan; the number with complex febrile seizure who required hospitalization was higher than during BA.1/BA.2 predominance. The COVID-19 vaccination rate in children must be increased to prevent hospitalization for COVID-19 and to prepare for current and future variant outbreaks.

    DOI: 10.1097/INF.0000000000003894

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  • Epidemic of influenza A(H1N1)pdm09 analyzed by full genome sequences and the first case of oseltamivir-resistant strain in Myanmar 2017. 国際誌

    Su Mon Kyaw Win, Reiko Saito, Nay Chi Win, Di Ja Lasham, Yadanar Kyaw, Nay Lin, Khin Nyo Thein, Irina Chon, Takashi Odagiri, Win Thein, Latt Latt Kyaw, Ommar Swe Tin, Akihiko Saitoh, Tsutomu Tamura, Chika Hirokawa, Yuko Uchida, Takehiko Saito, Shinji Watanabe, Takato Odagiri, Kazuhiro Kamata, Hidekazu Osada, Clyde Dapat, Hisami Watanabe, Htay Htay Tin

    PloS one   15 ( 3 )   e0229601   2020年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A community outbreak of human influenza A(H1N1)pdm09 virus strains was observed in Myanmar in 2017. We investigated the circulation patterns, antigenicity, and drug resistance of 2017 influenza A(H1N1)pdm09 viruses from Myanmar and characterized the full genome of influenza virus strains in Myanmar from in-patients and out-patients to assess the pathogenicity of the viruses. Nasopharyngeal swabs were collected from out-patients and in-patients with acute respiratory tract infections in Yangon and Pyinmana City in Myanmar during January-December 2017. A total of 215 out-patients and 18 in-patients infected with A(H1N1)pdm09 were detected by virus isolation and real-time RT-PCR. Among the positive patients, 90.6% were less than 14 years old. Hemagglutination inhibition (HI) antibody titers against A(H1N1)pdm09 viruses in Myanmar were similar to the recommended Japanese influenza vaccine strain for 2017-2018 seasons (A/Singapore/GP1908/2015) and WHO recommended 2017 southern hemisphere vaccine component (A/Michigan/45/2015). Phylogenetic analysis of the hemagglutinin sequence showed that the Myanmar strains belonged to the genetic subclade 6B.1, possessing mutations of S162N and S164T at potential antigenic sites. However, the amino acid mutation at position 222, which may enhance the severity of disease and mortality, was not found. One case with no prior history of oseltamivir treatment possessed H275Y mutated virus in neuraminidase (NA), which confers resistance to oseltamivir and peramivir with elevated IC50 values. The full genome sequence of Myanmar strains showed no difference between samples from in-patients and out-patients, suggesting no additional viral mutations associated with patient severity. Several amino acid changes were observed in PB2, PB1, and M2 of Myanmar strains when compared to the vaccine strain and other Asian strains. However, no mutations associated with pathogenicity were found in the Myanmar strains, suggesting that viral factors cannot explain the underlying reasons of the massive outbreak in Myanmar. This study reported the first detection of an oseltamivir-resistant influenza virus in Myanmar, highlighting the importance of continuous antiviral monitoring and genetic characterization of the influenza virus in Myanmar.

    DOI: 10.1371/journal.pone.0229601

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  • Phylogeographic analysis of human influenza A and B viruses in Myanmar, 2010-2015 査読

    Khin Thu Zar Htwe, Clyde Dapat, Yugo Shobugawa, Takashi Odagiri, Akinobu Hibino, Hiroki Kondo, Ren Yagami, Takehiko Saito, Nobuhiro Takemae, Tsutomu Tamura, Hisami Watanabe, Yadanar Kyaw, Nay Lin, Yi Yi Myint, Htay Htay Tin, Win Thein, Latt Latt Kyaw, Pan Ei Soe, Makoto Naito, Hassan Zaraket, Hiroshi Suzuki, Takashi Abe, Reiko Saito

    PLOS ONE   14 ( 1 )   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    We investigated the circulation patterns of human influenza A and B viruses in Myanmar between 2010 and 2015 by analyzing full HA genes. Upper respiratory tract specimens were collected from patients with symptoms of influenza-like illness. A total of 2,860 respiratory samples were screened by influenza rapid diagnostic test, of which 1,577 (55.1%) and 810 (28.3%) were positive for influenza A and B, respectively. Of the 1,010 specimens that were positive for virus isolation, 370 (36.6%) were A(H1N1) pdm09, 327 (32.4%) were A(H3N2), 130 (12.9%) B(Victoria), and 183 (18.1%) were B(Yamagata) viruses. Our data showed that influenza epidemics mainly occurred during the rainy season in Myanmar. Our three study sites, Yangon, Pyinmana, and Pyin Oo Lwin had similar seasonality and circulating type and subtype of influenza in a given year. Moreover, viruses circulating in Myanmar during the study period were closely related genetically to those detected in Thailand, India, and China. Phylogeographic analysis showed that A(H1N1) pdm09 viruses in Myanmar originated from Europe and migrated to other countries via Japan. Similarly, A (H3N2) viruses in Myanmar originated from Europe, and disseminated to the various countries via Australia. In addition, Myanmar plays a key role in reseeding of influenza B viruses to Southeast Asia and East Asia as well as Europe and Africa. Thus, we concluded that influenza virus in Myanmar has a strong link to neighboring Asian countries, Europe and Oceania.

    DOI: 10.1371/journal.pone.0210550

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  • Isolation of Saffold Virus Type 2 from Children with Acute Respiratory Infections by Using the RD-18S-Niigata Cell Line 査読

    Yoko Aoki, Yohei Matoba, Shizuka Tanaka, Kazue Yahagi, Chika Hirokawa, Tsutomu Tamura, Tsutomu Itagaki, Yoko Matsuzaki, Katsumi Mizuta

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   68 ( 5 )   438 - 441   2015年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATL INST INFECTIOUS DISEASES  

    DOI: 10.7883/yoken.HID.2015.093

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  • Detection of Human Coronavirus NL63 and 0C43 in Children with Acute Respiratory Infections in Niigata, Japan, between 2010 and 2011 査読

    Miyako Kon, Kaori Watanabe, Takashi Tazawa, Kanako Watanabe, Tsutomu Tamura, Hiroyuki Tsukagoshi, Masahiro Noda, Hirokazu Kimura, Katsumi Mizuta

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   65 ( 3 )   270 - 272   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATL INST INFECTIOUS DISEASES  

    DOI: 10.7883/yoken.65.270

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  • Imported Cases of Measles in Niigata, Japan in 2011

    Kanako Watanabe, Kaori Watanabe, Takashi Tazawa, Miyako Kon, Tsutomu Tamura, Katsuhiro Komase

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   65 ( 3 )   268 - 270   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATL INST INFECTIOUS DISEASES  

    DOI: 10.7883/yoken.65.268

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  • Phylogenetic Analysis of an Off-Seasonal Influenza Virus A (H3N2) in Niigata, Japan, 2010 査読

    Clyde Dapat, Yasushi Suzuki, Miyako Kon, Tsutomu Tamura, Reiko Saito, Isolde C. Dapat, Osamu Yamazaki, Takato Odagiri, Seiichiro Fujisaki, Hiroshi Suzuki

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   64 ( 3 )   237 - 241   2011年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATL INST INFECTIOUS DISEASES  

    The objective of this study was to characterize the off-seasonal influenza virus A subtype H3N2, which caused an outbreak in an elderly hospital in Niigata, Japan. Virus isolates were subtyped by the hemagglutination-inhibition test and screened for antiviral drug sensitivity by real-time PCR using cycling probe technology and the 50% inhibitory concentration (IC50) method. Whole genome sequencing was performed in order to determine the phylogeny of the outbreak virus. Seven virus isolates were analyzed in this study, and the results showed that all belonged to the influenza virus A (H3N2). These viruses exhibited the S31N mutation in M2, which confers resistance to amantadine. The results of the IC50 analysis showed that these viruses were sensitive to both oseltamivir and zanamivir. Whole genome analysis revealed that the virus was similar to the A/Perth/16/2009 strain and that it is a triple reassortant virus with a 3 + 3 + 2 pattern of segment recombination.

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  • Identification of Oseltamivir Resistance among Pandemic and Seasonal Influenza A (H1N1) Viruses by an His275Tyr Genotyping Assay Using the Cycling Probe Method 査読

    Yasushi Suzuki, Reiko Saito, Isamu Sato, Hassan Zaraket, Makoto Nishikawa, Tsutomu Tamura, Clyde Dapat, Isolde Caperig-Dapat, Tatiana Baranovich, Takako Suzuki, Hiroshi Suzuki

    JOURNAL OF CLINICAL MICROBIOLOGY   49 ( 1 )   125 - 130   2011年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER SOC MICROBIOLOGY  

    Neuraminidase inhibitors are agents used against influenza viruses; however, the emergence of drug-resistant strains is a major concern. Recently, the prevalence of oseltamivir-resistant seasonal influenza A (H1N1) virus increased globally and the emergence of oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses was reported. In this study, we developed a cycling probe real-time PCR method for the detection of oseltamivir-resistant seasonal influenza A (H1N1) and pandemic influenza A (H1N1) 2009 viruses. We designed two sets of primers and probes that were labeled with 6-carboxyfluorescein or 6-carboxy-X-rhodamine to identify single nucleotide polymorphisms (SNPs) that correspond to a histidine and a tyrosine at position 275 in the neuraminidase protein, respectively. These SNPs confer susceptibility and resistance to oseltamivir, respectively. In the 2007-2008 season, the prevalence of oseltamivir-resistant H1N1 viruses was 0% (0/72), but in the 2008-2009 season, it increased to 100% (282/282). In the 2009-2010 season, all of the pandemic influenza A (H1N1) 2009 viruses were susceptible to oseltamivir (0/73, 0%). This method is sensitive and specific for the screening of oseltamivir-resistant influenza A (H1N1) viruses. This method is applicable to routine laboratory-based monitoring of drug resistance and patient management during antiviral therapy.

    DOI: 10.1128/JCM.01401-10

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  • Molecular Epidemiological Study of Rotavirus and Norovirus Infections among Children with Acute Gastroenteritis in Nha Trang, Vietnam, December 2005-June 2006 査読

    Tsutomu Tamura, Makoto Nishikawa, Dang Duc Anh, Hiroshi Suzuki

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   63 ( 6 )   405 - 411   2010年11月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATL INST INFECTIOUS DISEASES  

    A molecular epidemiological study of rotavirus (RV) and norovirus (NoV) infections was carried out in Nha Trang city in Vietnam between December 2005 and June 2006 RV and NoV were detected in 87 (47 5%) and 12 (6 6%) of the 183 fecal specimens from children hospitalized with acute gastroenteritis, respectively The majority of patients with RV and NoV were children younger than 2 years of age The most frequent RV genotypes detected were G3 (n = 37, 42 5%) and G1 (n = 28, 32 2%) for G type, P[8] (n = 61, 70 1%) for P type, and G3P[8] (n = 33, 38 0%) and G1P[8] (n = 18, 20 7%) for the G and P genotype combination GII 12 was the most common genotype (6/12, 50%) for NoV, followed by GII 4(4/12, 33 3%), and we also identified a rare type (GII 19) The results of this study highlight the increased incidence of G3P[8] and the presence of many OP354-like P[8] RVs, as well as the GII 4 2003 Asia variant of NoVs Furthremore, the first case of GII 19 of NoV in Vietnam is reported

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  • Estimation of focus reduction neutralization test for measurement of neutralizing antibody titer against Japanese encephalitis virus 査読

    Kanako Watanabe, Chika Hirokawa, Miyako Kon, Tsutomu Tamura, Makoto Nishikawa

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   61 ( 5 )   424 - 425   2008年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATL INST INFECTIOUS DISEASES  

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