Updated on 2025/07/14

写真a

 
KAYAMORI Hiromi
 
Organization
University Medical and Dental Hospital Patient Support Center Specially Appointed Assistant Professor
Title
Specially Appointed Assistant Professor
External link

Degree

  • 博士(医学) ( 2019.3   新潟大学 )

Research History

  • Niigata University   Patient Support Center, University Medical and Dental Hospital   Specially Appointed Assistant Professor

    2025.7

  • Niigata University   Graduate School of Medical and Dental Sciences   Specially Appointed Assistant Professor

    2024.4 - 2025.6

 

Papers

  • Bidirectional Shunt Trajectory in Ventricular Septal Defect With Eisenmenger's Syndrome.

    Hiromi Kayamori, Takeshi Kashimura, Yosuke Horii, Tsutomu Kanazawa, Toshio Fujita, Naoki Kubota, Yasuhiro Ikami, Toshiki Takano, Takeshi Okubo, Makoto Hoyano, Takao Yanagawa, Takuya Ozawa, Kazuyuki Ozaki, Tohru Minamino

    Circulation journal : official journal of the Japanese Circulation Society   82 ( 11 )   2925 - 2926   2018.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1253/circj.CJ-18-0332

    PubMed

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  • Amlodipine Inhibits Vascular Cell Senescence and Protects Against Atherogenesis Through the Mechanism Independent of Calcium Channel Blockade.

    Hiromi Kayamori, Ippei Shimizu, Yohko Yoshida, Yuka Hayashi, Masayoshi Suda, Ryutaro Ikegami, Goro Katsuumi, Takayuki Wakasugi, Tohru Minamino

    International heart journal   59 ( 3 )   607 - 613   2018.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    Vascular cells have a finite lifespan and eventually enter irreversible growth arrest called cellular senescence. We have previously suggested that vascular cell senescence contributes to the pathogenesis of human atherosclerosis. Amlodipine is a mixture of two enantiomers, one of which (S- enantiomer) has L-type channel blocking activity, while the other (R+ enantiomer) shows ~1000-fold weaker channel blocking activity than S- enantiomer and has other unknown effects. It has been reported that amlodipine inhibits the progression of atherosclerosis in humans, but the molecular mechanism of this beneficial effect remains unknown. Apolipoprotein E-deficient mice on a high-fat diet were treated with amlodipine, its R+ enantiomer or vehicle for eight weeks. Compared with vehicle treatment, both amlodipine and the R+ enantiomer significantly reduced the number of senescent vascular cells and inhibited plaque formation to a similar extent. Expression of the pro-inflammatory molecule interleukin-1β was markedly upregulated in vehicle-treated mice, but was inhibited to a similar extent by treatment with amlodipine or the R+ enantiomer. Likewise, activation of p53 (a critical inducer of senescence) was markedly suppressed by treatment with amlodipine or the R+ enantiomer. These results suggest that amlodipine inhibits vascular cell senescence and protects against atherogenesis at least partly by a mechanism that is independent of calcium channel blockade.

    DOI： 10.1536/ihj.17-265

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  • Peripheral Gamma-aminobutyric Acid(gaba) Signaling in Brown Adipose Tissue Induces Metabolic Dysfunction in Obesity Reviewed

    Ryutaro Ikegami, Ippei Shimizu, Takeshi Sato, Shuang Jiao, Yohko Yoshida, Masayoshi Suda, Yuka Hayashi, Goro Katsuumi, Hiromi Kayamori, Tohru Minamino

    CIRCULATION   132   2015.11

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    Language：English   Publisher：LIPPINCOTT WILLIAMS & WILKINS  

    Web of Science

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  • Atrioventricular dissociation mimicking pulsus paradoxus and palsus alternans.

    Hiromi Kayamori, Takeshi Kashimura, Masato Oda, Makoto Kodama

    Internal medicine (Tokyo, Japan)   51 ( 24 )   3439 - 40   2012

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    Language：English   Publishing type：Research paper (scientific journal)  

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MISC

  • Endothelial p53 Has a Crucial Role for Vascular Dysfunction Reviewed

    Hiromi Kayamori, Ippei Shimizu, Masataka Yokoyama, Yohko Yoshida, Masayoshi Suda, Yuka Hayashi, Jiao Shuang, Ryutaro Ikegami, Goro Katsuumi, Tohru Minamino

    JOURNAL OF CARDIAC FAILURE   20 ( 10 )   S151 - S151   2014.10

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS  

    DOI： 10.1016/j.cardfail.2014.07.121

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  • Vascular Rarefaction Mediates Whitening of Brown Fat in Dietary Obesity Reviewed

    Ippei Shimizu, Yohko Yoshida, Masayoshi Suda, Yuka Hayashi, Jiao Shuang, Ryutaro Ikegami, Goro Katsuumi, Hiromi Kayamori, Kenneth Walsh, Tohru Minamino

    JOURNAL OF CARDIAC FAILURE   20 ( 10 )   S148 - S148   2014.10

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS  

    DOI： 10.1016/j.cardfail.2014.07.102

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  • p53-induced Cardio - Bone Marrow Axis Remodeling Deteriorates Cardiac Function During Pressure Overload Reviewed

    Yohko Yoshida, Ippei Shimizu, Goro Katsuumi, Masayoshi Suda, Yuka Hayashi, Ryutaro Ikegami, Hiromi Kayamori, Shuang Jiao, Tohru Minamino

    JOURNAL OF CARDIAC FAILURE   20 ( 10 )   S150 - S151   2014.10

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS  

    DOI： 10.1016/j.cardfail.2014.07.118

    Web of Science

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