2026/02/06 更新

写真a

ツルマ　ハヤト
霍間　勇人
TSURUMA Hayato
所属
教育研究院 医歯学系 特任助教
医歯学総合研究科 特任助教
職名
特任助教
外部リンク

学位

  • 学士(医学) （ 2015年3月   自治医科大学 ）

経歴

  • 新潟大学   教育研究院 医歯学系   特任助教

    2024年4月 - 現在

  • 新潟大学   医歯学総合研究科   特任助教

    2024年4月 - 現在

 

論文

  • Species-specific outcomes and role of infectious disease consultation in peritoneal dialysis infections caused by nontuberculous mycobacteria: A 10-year retrospective analysis. 国際誌

    Ikumi Yamagishi, Yuuki Bamba, Naoto Kanno, Masahiro Ui, Hayato Tsuruma, Mariko Hakamata, Hideyuki Ogata, Satoshi Shibata, Koji Matsuo, Nobumasa Aoki, Kazuko Kawamura, Yasuyoshi Ohshima, Satoshi Watanabe, Hiroshi Moro, Toshiyuki Koya, Shin Goto, Suguru Yamamoto, Toshiaki Kikuchi

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis   8968608251389780 - 8968608251389780   2025年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BackgroundInfections can make it difficult to continue peritoneal dialysis (PD). Nontuberculous mycobacteria-associated PD (NTM-PD) infections, while rare, frequently pose a treatment challenge due to their intractable nature and the lack of established therapeutic guidelines. As a result, we aimed to investigate the clinical characteristics of NTM infections in patients undergoing PD.MethodsWe retrospectively examined consecutive patients with NTM-PD infections from 2012 to 2022. The cases were identified through microbiological records. The primary outcomes were all-cause mortality and transition to hemodialysis. Secondary outcomes included treatment duration and antimicrobial regimens. Outcomes were compared across different NTM species and between cases with and without infectious disease (ID) consultation.ResultsAmong 177 patients undergoing PD, we identified 22 NTM infections in 20 patients. The predominant species were M. chelonae (36%), M. fortuitum (36%), and M. abscessus (23%). Twelve patients were transitioned to hemodialysis, with no mortality. All M. abscessus infections (n = 5) required transition to hemodialysis, compared to 46% in other species. ID consultation (n = 15) was linked to more frequent antimicrobial susceptibility testing (60% vs. 0%, p < .05), longer treatment duration (5.7 vs. 1.2 months, p < .05), and increased use of combination therapies (100% vs. 43%, p < .05). However, ID consultation did not affect the frequency of transition to hemodialysis.ConclusionEarly identification of NTM species and timely ID consultation can help optimize management strategies for these challenging infections.

    DOI： 10.1177/08968608251389780

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  • Bloodstream Infection Caused by Mycobacterium neoaurum in a Primary Central Nervous System Lymphoma Patient with Toxic Epidermal Necrolysis: A Case Report.

    Mariko Hakamata, Hideyuki Ogata, Naoto Kanno, Asumi Suzuki, Ikumi Yamagishi, Kazusige Sato, Masahiro Ui, Hayato Tsuruma, Yuuki Bamba, Satoshi Shibata, Hiromi Cho, Mizuho Sato, Nobumasa Aoki, Hiroshi Moro, Toshiaki Kikuchi

    Internal medicine (Tokyo, Japan)   2025年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Mycobacterium neoaurum is a rare cause of bacteremia, predominantly affecting immunocompromised hosts with indwelling catheters. A 75-year-old man receiving high-dose methotrexate therapy for primary central nervous system lymphoma without a central venous catheter (CVC) presented with fever. The acid-fast bacilli isolated from his blood cultures were identified as M. neoaurum through 16S rRNA sequencing. Despite broad-spectrum antimicrobial therapy, the patient developed persistent pancytopenia and toxic epidermal necrolysis, which ultimately led to multiple organ failure. M. neoaurum should be considered a potential pathogen in immunocompromised hosts, even in the absence of a CVC. Rapid identification and appropriate antimicrobial selection are essential when mycobacteria are isolated from blood culture.

    DOI： 10.2169/internalmedicine.5633-25

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  • 血清型6型Erysipelothrix rhusiopathiaeによる敗血症の一例

    谷川 俊也, 袴田 真理子, 尾方 英至, 菅野 直人, 鈴木 明日美, 山岸 郁美, 宇井 雅博, 霍間 勇人, 番場 祐基, 柴田 怜, 張 仁美, 佐藤 瑞穂, 青木 信将, 茂呂 寛, 菊地 利明

    感染症学雑誌   99 ( 1 )   67 - 67   2025年1月

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    記述言語：日本語   出版者・発行元：(一社)日本感染症学会  

    J-GLOBAL

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  • Bloodstream infection caused by Erysipelothrix rhusiopathiae serotype 6: Case report and literature review. 国際誌

    Asumi Suzuki, Mariko Hakamata, Syunya Tanikawa, Naoto Kanno, Ikumi Yamagishi, Masahiro Ui, Hayato Tsuruma, Yuuki Bamba, Hideyuki Ogata, Satoshi Shibata, Hiromi Cho, Mizuho Sato, Nobumasa Aoki, Hiroshi Moro, Toshiaki Kikuchi

    IDCases   41   e02329   2025年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Erysipelothrix rhusiopathiae is a zoonotic, facultatively anaerobic, non-spore-forming, gram-positive bacillus. Although the serotypes and phylogenetic clades of E. rhusiopathiae strains isolated from animals have been shown to be closely related, the serotype identification of clinical isolates from human patients remains limited. We report a case of a 66-year-old woman with bacteremia caused by E. rhusiopathiae serotype 6. The patient had been admitted with aspiration pneumonia and heat stroke. She had no animal-related occupational history and had been receiving long-term oral prednisolone therapy for mixed connective tissue disease. Upon confirmation of E. rhusiopathiae positivity on blood cultures, she was treated with intravenous ampicillin for 10 days and achieved complete recovery. Agar gel precipitation and polymerase chain reaction tests identified the isolate as serotype 6. Surface protective antigen (Spa) typing by sequence analysis suggested a marine animal origin of infection. To the best of our knowledge, this is the first reported case of bacteremia caused by E. rhusiopathiae serotype 6 in humans. Spa typing through sequence analysis may provide variable information for identifying the infection source. E. rhusiopathiae carrying the SpaB gene should be considered in immunosuppressed patients, regardless of animal exposure history. Further studies are needed to elucidate the epidemiological distribution of serotypes among human clinical isolates.

    DOI： 10.1016/j.idcr.2025.e02329

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  • Microbiological Etiology and Detection of Drug-Resistant Bacteria in Pneumonia in Patients with Organophosphate Poisoning in the Intensive Care Unit. 国際誌

    Naoto Kanno, Yuuki Bamba, Shimon Aoki, Ikumi Yamagishi, Masahiro Ui, Hayato Tsuruma, Mariko Hakamata, Hideyuki Ogata, Satoshi Shibata, Kou Matsui, Hiromi Cho, Mizuho Sato, Nobumasa Aoki, Hiroshi Moro, Toshiyuki Koya, Kei Nishiyama, Toshiaki Kikuchi

    Infection and drug resistance   18   5853 - 5861   2025年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    PURPOSE: Organophosphate (OP) poisoning, a frequent method of suicide in the Asia-Pacific region and rural areas, inhibits cholinesterase (ChE), causing an acute cholinergic crisis. Pneumonia occurs in 20-50% of these cases, contributing to disease severity and mortality. However, data on the causative pathogens and the risk of drug-resistant bacteria in this patient population are limited. Thus, our study aimed to address these gaps. PATIENTS AND METHODS: This retrospective cohort study (April 2011-March 2023) investigated patients admitted to the intensive care unit (ICU) or emergency medical center at Niigata University Medical & Dental Hospital with acute OP poisoning. Data on patient demographics, pneumonia diagnosis, sputum culture results, prior antibiotic use, and risk factors for drug-resistant bacteria were collected. We also analyzed the detection rates of methicillin-resistant Staphylococcus aureus and SPICE (Serratia, Pseudomonas, indole-positive Proteus, Citrobacter, and Enterobacter) organisms. RESULTS: Among the 21 patients with OP poisoning, 13 (62%) developed pneumonia and received antibiotic treatment. They had a longer ICU stay, higher Sequential Organ Failure Assessment scores on admission, and lower serum ChE activity (<100 IU/L). Gram-negative bacilli (GNB) were observed in five sputum cultures from 12 patients with pneumonia, with Pseudomonas aeruginosa isolated from three cases. None of the patients had known risk factors for drug-resistant bacteria. CONCLUSION: Pneumonia in patients with OP poisoning was predominantly caused by GNB, particularly P. aeruginosa. Thus, despite the absence of known risk factors for drug-resistant bacteria, clinicians should consider the possibility of resistant pathogens when selecting empirical antibiotic therapy for pneumonia in these patients.

    DOI： 10.2147/IDR.S556334

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  • 当院におけるHIV感染症合併梅毒の検討

    柴田 怜, 霍間 勇人, 番場 祐基, 青木 信将, 知久 熙眞, 新保 明日香, 川口 玲, 茂呂 寛

    日本エイズ学会誌   26 ( 4 )   495 - 495   2024年11月

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    記述言語：日本語   出版者・発行元：(一社)日本エイズ学会  

    J-GLOBAL

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  • セフトリアキソン投与後の偽胆石症発症に関連するリスク因子の検討

    番場 祐基, 鈴木 明日美, 菅野 直人, 山岸 郁美, 宇井 雅博, 霍間 勇人, 袴田 真理子, 尾方 英至, 柴田 怜, 張 仁美, 佐藤 瑞穂, 青木 信将, 茂呂 寛, 小屋 俊之, 菊地 利明

    日本感染症学会総会・学術講演会・日本化学療法学会学術集会合同学会プログラム・抄録集   98回・72回   np206 - np206   2024年5月

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    記述言語：日本語   出版者・発行元：日本感染症学会・日本化学療法学会  

    J-GLOBAL

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  • 大腸菌による感染性硬膜下血腫の1例

    鈴木 明日美, 袴田 真理子, 菅野 直人, 山岸 郁美, 佐藤 和茂, 宇井 雅博, 霍間 勇人, 番場 祐基, 尾方 英至, 柴田 怜, 張 仁美, 佐藤 瑞穂, 青木 信将, 茂呂 寛, 菊地 利明

    感染症学雑誌   98 ( 1 )   120 - 121   2024年1月

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    記述言語：日本語   出版者・発行元：(一社)日本感染症学会  

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  • Mycolicibacterium neoaurum血流感染症の1例

    袴田 真理子, 尾方 英至, 菅野 直人, 鈴木 明日美, 山岸 郁美, 佐藤 和茂, 宇井 雅博, 霍間 勇人, 番場 祐基, 張 仁美, 佐藤 瑞穂, 柴田 怜, 青木 信将, 茂呂 寛, 菊地 利明

    感染症学雑誌   98 ( 1 )   97 - 97   2024年1月

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    記述言語：日本語   出版者・発行元：(一社)日本感染症学会  

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  • An adult case of atypical familial Mediterranean fever (pyrin-associated autoinflammatory disease) similar to adult-onset Still's disease. 国際誌

    Hayato Tsuruma, Hiroe Sato, Eriko Hasegawa, Yukiko Nozawa, Takeshi Nakatsue, Yoko Wada, Takeshi Kuroda, Yoshiki Suzuki, Masaaki Nakano, Ichiei Narita

    Clinical case reports   7 ( 4 )   801 - 805   2019年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    We present a 55-year-old woman with periodic fever and symptoms similar to adult-onset Still's disease (AOSD). She had a heterogeneous mutation of the MEFV gene and colchicine was effective. Atypical familial Mediterranean fever (pyrin-associated autoinflammatory disease) should be considered in patients with periodic fever accompanied by symptoms similar to AOSD.

    DOI： 10.1002/ccr3.2102

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