2024/10/12 更新

写真a

ナリタ マサミ
成田 正見
NARITA Masami
所属
大学院教育支援機構 大学院改革推進部門 特任教授
職名
特任教授
連絡先
メールアドレス
外部リンク

経歴

  • 新潟大学   大学院教育支援機構 大学院改革推進部門   特任教授

    2024年9月 - 現在

 

論文

  • Associations of parental education with children's infectious diseases and their mediating factors: the Japan Environment and Children's Study (JECS).

    Masami Narita, Midori Yamamoto, Kenichi Sakurai, Chisato Mori

    Journal of epidemiology   2024年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BackgroundParents' educational background is presumed to influence the incidence of vaccine-preventable diseases in children through their decisions about vaccinations and other family lifestyle choices. Regarding voluntary vaccination, a household's economic situation may also be associated with non-vaccination. Therefore, this study investigated the association between parental education and vaccine-preventable diseases (varicella, mumps, influenza [flu], pertussis, measles, and rubella) in children, which currently remains elusive.MethodsWe used datasets from the Japan Environment and Children's Study, which included 104,062 fetal records; our study population comprised 80,930 children up to the age of three years. The associations between parental educational background and children's infectious diseases were examined using binomial logistic regression analysis. The mediating effects of household income, vaccination, and smoking were examined using a path analysis.ResultsFor varicella, mumps, and influenza covered by voluntary vaccination, a higher education level of the father was associated with a lower incidence of infection. The association between mothers' education and children's infection was limited. There were both income-mediated and non-income-mediated pathways between parental education and voluntary vaccination. For pertussis, measles, and rubella, which are covered by routine vaccines, there was no association between parental education and the child's infection.ConclusionAn association between parental education and childhood infections was observed. Additionally, providing financial support for vaccination and communicating the benefits of vaccination in a way that parents at all levels of education can understand will help reduce the incidence of infectious diseases among children.

    DOI: 10.2188/jea.JE20240192

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  • A single injection of a sustained-release prostacyclin analog (ONO-1301MS) suppresses airway inflammation and remodeling in a chronic house dust mite-induced asthma model. 国際誌

    Yosuke Kimura, Toshiyuki Koya, Hiroshi Kagamu, Kenjiro Shima, Hirotaka Sakamoto, Hidenori Kawakami, Yoshifumi Hoshino, Toshiki Furukawa, Takuro Sakagami, Takashi Hasegawa, Masami Narita, Eiichi Suzuki, Ichiei Narita

    European journal of pharmacology   721 ( 1-3 )   80 - 5   2013年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    ONO-1301, a novel prostacyclin agonist with thromboxane A2 synthase inhibitory activity, is a useful agent for ameliorating airway allergic inflammation; however, its short-action feature implies a requirement for the frequent administration of this drug. Therefore, we investigated the effects of ONO-1301-loaded poly (d,l-lactic-co-glycolic acid) microspheres (ONO-1301MS; to release ONO-1301 for 3 weeks) on the airway inflammation and remodeling in chronic house dust mite (HDM)-induced model. Balb/c mice were exposed to an HDM extract intranasally for 5 days/week for 5 consecutive weeks. The mice received a single subcutaneous injection of ONO-1301MS or vehicle after 3 weeks of HDM exposure, followed by 2 additional weeks of HDM exposure. Forty-eight hours after the last HDM exposure, airway hyperresponsiveness to methacholine was assessed and bronchoalveolar lavage was performed. Lung specimens were excised and stained to check for goblet cell metaplasia, airway smooth muscle hypertrophy, and submucosal fibrosis. Mice receiving ONO-1301MS showed significantly lower airway hyperresponsiveness, airway eosinophilia, and induced T helper 2 cytokine production compared with mice receiving the vehicle. Histological findings such as goblet cell metaplasia, airway smooth muscle hypertrophy, and submucosal fibrosis were decreased in ONO-1301MS-treated mice compared with vehicle-treated mice. A single administration of ONO-1301MS achieved sustained elevation of its circulating level for 3 weeks. These data suggest that a single administration of ONO-1301MS may suppress airway hyperresponsiveness, airway allergic inflammation, and development of airway remodeling in chronic HDM-induced asthma model. This agent may be effective as an anti-inflammatory and remodeling drug in the practical treatment of asthma.

    DOI: 10.1016/j.ejphar.2013.09.051

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  • 3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 3: Synthesis, metabolic stability, and biological evaluation of optically active analogs. 国際誌

    Masaki Asada, Tetsuo Obitsu, Atsushi Kinoshita, Toshihiko Nagase, Tadahiro Yoshida, Yoshiyuki Yamaura, Hiroya Takizawa, Ken Yoshikawa, Kazutoyo Sato, Masami Narita, Hisao Nakai, Masaaki Toda, Yoshito Tobe

    Bioorganic & medicinal chemistry   18 ( 9 )   3212 - 23   2010年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A series of 3-(2-aminocarbonylphenyl)propanoic acid analogs possessing the (1R)-1-(3,5-dimethylphenyl)-3-methylbutylamine moiety on the carboxyamide side chain were synthesized and evaluated for their binding affinity for the EP1-4 receptors and their antagonist activity for the EP3 receptor. Rational drug design based on the structure of the metabolites in human liver microsomes led us to the discovery of another series of analogs. Several compounds were further evaluated for their in vivo efficacy in rats after oral administration and also for their pharmacokinetic profiles including in vitro stability in the liver microsomes.

    DOI: 10.1016/j.bmc.2010.03.028

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  • Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists. 国際誌

    Masaki Asada, Tetsuo Obitsu, Atsushi Kinoshita, Yoshihiko Nakai, Toshihiko Nagase, Isamu Sugimoto, Motoyuki Tanaka, Hiroya Takizawa, Ken Yoshikawa, Kazutoyo Sato, Masami Narita, Shuichi Ohuchida, Hisao Nakai, Masaaki Toda

    Bioorganic & medicinal chemistry letters   20 ( 8 )   2639 - 43   2010年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A series of novel N-acylsulfonamide analogs were synthesized and evaluated for their binding affinity and antagonist activity for the EP3 receptor subtype. Representative compounds were also evaluated for their inhibitory effect on PGE(2)-induced uterine contraction in pregnant rats. Among those tested, a series of N-acylbenzenesulfonamide analogs were found to be more potent than the corresponding carboxylic acid analogs in both the in vitro and in vivo evaluations. The structure activity relationships (SAR) are also discussed.

    DOI: 10.1016/j.bmcl.2010.02.034

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  • 3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. part 2: optimization of the side chains to improve in vitro and in vivo potencies. 国際誌

    Masaki Asada, Maki Iwahashi, Tetsuo Obitsu, Atsushi Kinoshita, Yoshihiko Nakai, Takahiro Onoda, Toshihiko Nagase, Motoyuki Tanaka, Yoshiyuki Yamaura, Hiroya Takizawa, Ken Yoshikawa, Kazutoyo Sato, Masami Narita, Shuichi Ohuchida, Hisao Nakai, Masaaki Toda

    Bioorganic & medicinal chemistry   18 ( 4 )   1641 - 58   2010年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A series of 3-[2-{[(3-methyl-1-phenylbutyl)amino]carbonyl}-4-(phenoxymethyl)phenyl]propanoic acid analogs were synthesized and evaluated for their in vitro potency. In most cases, introduction of one or two substituents into the two phenyl moieties resulted in the tendency of an increase or retention of in vitro activities. Several compounds, which showed excellent subtype selectivity, were evaluated for their inhibitory effect against PGE(2)-induced uterine contraction in pregnant rats, which is thought to be mediated by the EP3 receptor subtype. The structure-activity relationships (SARs) are also discussed.

    DOI: 10.1016/j.bmc.2009.12.068

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  • 3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 1: discovery and exploration of the carboxyamide side chain. 国際誌

    Masaki Asada, Tetsuo Obitsu, Toshihiko Nagase, Motoyuki Tanaka, Yoshiyuki Yamaura, Hiroya Takizawa, Ken Yoshikawa, Kazutoyo Sato, Masami Narita, Shuichi Ohuchida, Hisao Nakai, Masaaki Toda

    Bioorganic & medicinal chemistry   18 ( 1 )   80 - 90   2010年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A series of 3-(2-aminocarbonyl-4-phenoxymethylphenyl)propanoic acid analogs were synthesized and evaluated for their EP3 antagonist activity in the presence of additive serum albumin. Several compounds were biologically evaluated for their in vivo efficacy with respect to the PGE(2)-induced uterine contraction in pregnant rats as well as their pharmacokinetics. The discovery process of these potent and selective EP3 antagonists and their structure activity relationship are also presented.

    DOI: 10.1016/j.bmc.2009.11.023

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  • Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists. 国際誌

    Masaki Asada, Tetsuo Obitsu, Toshihiko Nagase, Isamu Sugimoto, Yoshiyuki Yamaura, Kazutoyo Sato, Masami Narita, Shuichi Ohuchida, Hisao Nakai, Masaaki Toda

    Bioorganic & medicinal chemistry   17 ( 18 )   6567 - 82   2009年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A series of acrylic acids and their structurally related compounds were evaluated for their binding affinity to four EP receptor subtypes (EP1-4). Starting from the initial hit 3, which was discovered in our in-house library, compounds 4 and 5 were identified as new chemical leads as candidates for further optimization towards a selective EP3 receptor antagonist. The identification process of these compounds and their pharmacokinetic profiles are presented.

    DOI: 10.1016/j.bmc.2009.08.007

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  • Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo. 国際誌

    Tatsuya Hoshino, Tadashi Nakaya, Takashi Homan, Ken-ichiro Tanaka, Yukihiko Sugimoto, Wataru Araki, Masami Narita, Shuh Narumiya, Toshiharu Suzuki, Tohru Mizushima

    The Journal of biological chemistry   282 ( 45 )   32676 - 88   2007年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Amyloid-beta peptides (Abeta), generated by proteolysis of the beta-amyloid precursor protein (APP) by beta- and gamma-secretases, play an important role in the pathogenesis of Alzheimer disease (AD). Inflammation is also believed to be integral to the pathogenesis of AD. Here we show that prostaglandin E(2) (PGE(2)), a strong inducer of inflammation, stimulates the production of Abeta in cultured human embryonic kidney (HEK) 293 or human neuroblastoma (SH-SY5Y) cells, both of which express a mutant type of APP. We have demonstrated using subtype-specific agonists that, of the four main subtypes of PGE(2) receptors (EP(1-4)), EP(4) receptors alone or EP(2) and EP(4) receptors together are responsible for this PGE(2)-stimulated production of Abeta in HEK293 or SH-SY5Y cells, respectively. An EP(4) receptor antagonist suppressed the PGE(2)-stimulated production of Abeta in HEK293 cells. This stimulation was accompanied by an increase in cellular cAMP levels, and an analogue of cAMP stimulated the production of Abeta, demonstrating that increases in the cellular level of cAMP are responsible for the PGE(2)-stimulated production of Abeta. Immunoblotting experiments and direct measurement of gamma-secretase activity suggested that PGE(2)-stimulated production of Abeta is mediated by activation ofgamma-secretase but not of beta-secretase. Transgenic mice expressing the mutant type of APP showed lower levels of Abeta in the brain, when they were crossed with mice lacking either EP(2) or EP(4) receptors, suggesting that PGE(2)-mediated activation of EP(2) and EP(4) receptors is involved in the production of Abeta in vivo and in the pathogenesis of AD.

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  • Stimulation of prostanoid IP and EP(2) receptors dilates retinal arterioles and increases retinal and choroidal blood flow in rats. 国際誌

    Asami Mori, Maki Saito, Kenji Sakamoto, Masami Narita, Tsutomu Nakahara, Kunio Ishii

    European journal of pharmacology   570 ( 1-3 )   135 - 41   2007年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We examined the effects of vasodilatory prostaglandins (prostacyclin and prostaglandin E(2)) and selective agonists for prostanoid EP(2) and EP(4) receptor on the diameters of retinal blood vessels and fundus (retinal/choroidal) blood flow in rats. Male Wistar rats (8- to 10-week-old) were treated with tetrodotoxin (50 microg/kg, i.v.) to eliminate any nerve activity and prevent movement of the eye and infused with a mixture solution of norepinephrine and epinephrine (1:9) to maintain adequate systemic circulation under artificial ventilation. Fundus images were captured with a digital camera that was equipped with the special objective lens for small animals, and the diameters of retinal arterioles and venules were measured on a personal computer. Fundus blood flow was estimated using a laser Doppler flowmetry. Intravenous infusions of prostacyclin and prostaglandin E(2) dilated retinal blood vessels, increased fundus blood flow and decreased systemic blood pressure in a dose-dependent manner. The effects of vasodilatory prostaglandins on retinal arterioles were greater than those on retinal venules. Similarly, a prostanoid EP(2) receptor agonist (ONO-AE1-259-01) dilated retinal blood vessels, and increased fundus blood flow and decreased systemic blood pressure. However, a prostanoid EP(4) receptor agonist (ONO-AE1-329) failed to increase fundus blood flow, despite its comparable depressor response with those to vasodilatory prostaglandins and the prostanoid EP(2) receptor agonist. The responses to forskolin, an activator of adenylyl cyclase, were very similar to those to prostacyclin and the prostanoid EP(2) receptor agonist. These results suggest that prostacyclin and prostaglandin E(2) act as vasodilators in retinal and choroidal circulation, and prostanoid IP and EP(2) receptors play an important role in the regulation of ocular hemodynamics in rats.

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  • Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. 国際誌

    Hideki Amano, Izumi Hayashi, Hirahito Endo, Hidero Kitasato, Shohei Yamashina, Takayuki Maruyama, Michiyoshi Kobayashi, Kazutoyo Satoh, Masami Narita, Yukihiko Sugimoto, Takahiko Murata, Hirokuni Yoshimura, Shuh Narumiya, Masataka Majima

    The Journal of experimental medicine   197 ( 2 )   221 - 32   2003年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Nonsteroidal antiinflammatories are known to suppress incidence and progression of malignancies including colorectal cancers. However, the precise mechanism of this action remains unknown. Using prostaglandin (PG) receptor knockout mice, we have evaluated a role of PGs in tumor-associated angiogenesis and tumor growth, and identified PG receptors involved. Sarcoma-180 cells implanted in wild-type (WT) mice formed a tumor with extensive angiogenesis, which was greatly suppressed by specific inhibitors for cyclooxygenase (COX)-2 but not for COX-1. Angiogenesis in sponge implantation model, which can mimic tumor-stromal angiogenesis, was markedly suppressed in mice lacking EP3 (EP3(-/-)) with reduced expression of vascular endothelial growth factor (VEGF) around the sponge implants. Further, implanted tumor growth (sarcoma-180, Lewis lung carcinoma) was markedly suppressed in EP3(-/-), in which tumor-associated angiogenesis was also reduced. Immunohistochemical analysis revealed that major VEGF-expressing cells in the stroma were CD3/Mac-1 double-negative fibroblasts, and that VEGF-expression in the stroma was markedly reduced in EP3(-/-), compared with WT. Application of an EP3 receptor antagonist inhibited tumor growth and angiogenesis in WT, but not in EP3(-/-). These results demonstrate significance of host stromal PGE(2)-EP3 receptor signaling in tumor development and angiogenesis. An EP3 receptor antagonist may be a candidate of chemopreventive agents effective for malignant tumors.

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