Updated on 2025/07/04

写真a

 
NISHIJIMA Haruna
 
Organization
Academic Assembly Institute of Medicine and Dentistry Health Sciences Assistant Professor
Faculty of Medicine School of Health Sciences Medical Technology Assistant Professor
Title
Assistant Professor
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Degree

  • 博士（医学） ( 2022.3   千葉大学 )

Research Areas

  • Life Science / Hygiene and public health (laboratory)

  • Life Science / Virology

Research History (researchmap)

  • Niigata University   Faculty of Medicine School of Health Sciences   Assistant Professor

    2025.6

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  • Niigata University

    2025.6

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  • 国立健康危機管理研究機構 国立感染症研究所   インフルエンザ研究センター   協力研究員

    2025.6

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  • 国立健康危機管理研究機構, 国立感染症研究所   インフルエンザ研究センター第五室   研究員

    2025.4 - 2025.5

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  • National Institute of Infectious Diseases   Researcher

    2021.10 - 2025.3

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  • 千葉県衛生研究所   ウイルス・昆虫医科学研究室   研究員

    2015.4 - 2021.9

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  • 千葉県東総食肉衛生検査所   BSE検査課   技師

    2013.4 - 2015.3

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Research History

  • Niigata University   Health Sciences, Institute of Medicine and Dentistry, Academic Assembly   Assistant Professor

    2025.6

  • Niigata University   Medical Technology, School of Health Sciences, Faculty of Medicine   Assistant Professor

    2025.6

Education

  • 千葉大学大学院   医学薬学府   先端医学薬学専攻 博士課程

    2018.4 - 2022.3

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  • Niigata University   保健学研究科   検査技術科学分野 修士課程

    2011.4 - 2013.3

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  • Niigata University   医学部保健学科   検査技術科学専攻

    2007.4 - 2011.3

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Professional Memberships

 

Papers

  • Variability in single radial immunodiffusion (SRID) potency affected by influenza vaccine reference antigen/antiserum combinations: relationship between dissociation constant and robustness of SRID potency

    Haruna Nishijima, Noriko Shimasaki, Tomoko Kuwahara, Yusuke Nakai, Kazuya Nakamura, Kayoko Sato, Keiko Murano, Shigeyuki Itamura, Akihide Ryo, Yuichi Harada

    Japanese journal of infectious diseases   2025.6

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    Authorship：Lead author,　Corresponding author  

    DOI： 10.7883/yoken.JJID.2024.196

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  • Establishment of reference reagents for single-radial-immunodiffusion assay on the 2022/23 seasonal influenza vaccine in Japan and their quality validation. Reviewed

    Noriko Shimasaki, Tomoko Kuwahara, Haruna Nishijima, Kazuya Nakamura, Kayoko Sato, Keiko Murano, Shigeyuki Itamura, Yukiko Akahori, Emi Takashita, Noriko Kishida, Tomoko Arita, Mina Nakauchi, Makoto Takeda, Hideki Hasegawa, Akihide Ryo, Yuichi Harada

    Japanese journal of infectious diseases   2023.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    Potency test of influenza vaccine is currently performed using a single-radial-immunodiffusion (SRID) assay, which requires a reference antigen and anti-hemagglutinin (HA) serum as reference reagents. The reagents must be newly prepared each time the strain used for vaccine production is changed. Establishing reference reagents with consistent quality is, therefore, crucial to accurately and precisely conduct vaccine potency tests. Here, we established the reference reagents for the SRID assay to conduct lot release tests of quadrivalent influenza vaccines in Japan for the 2022/23 influenza season. The potency stability during storage of some reference antigens was confirmed. Furthermore, we evaluated the cross-reactivity of each antiserum raised against the HA protein of two lineages of influenza B virus toward the different lineage of influenza B virus antigen to select a suitable procedure of SRID assay for accurate measurement. Finally, the intra-laboratory reproducibility of the SRID assay using the established reference reagents was validated, and then the SRID reagents had sufficiently consistent quality comparable to that of the reagents used for testing vaccines in past influenza seasons. Our study could contribute to the quality control of influenza vaccines.

    DOI： 10.7883/yoken.JJID.2023.218

    PubMed

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  • A Brief Questionnaire on Healthcare Workers’ Awareness Toward the COVID-19 Vaccine and Antibody Tests Reviewed

    Haruna Nishijima

    Journal of Disaster Research   2022.10

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    Publishing type：Research paper (scientific journal)  

    File： Fujipress_JDR-18-1-3.pdf

    DOI： 10.20965/jdr.2023.p0021

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  • Diagnostic Significance of Lactate Dehydrogenase in Measles Virus Reinfection Cases. Reviewed International journal

    Haruna Nishijima, Tomoko Ogawa, Hiroshi Shirasawa

    Microbiology and immunology   2022.7

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Lactate dehydrogenase (LDH) levels in measles virus (MeV) reinfection cases for the diagnosis of measles have not been extensively studied. Thus, we evaluated the significance of serum LDH in the immune response of patients with MeV reinfection in comparison with those of patients with primary infection. Among 70 patients who tested positive for MeV-RNA, 42 with high MeV-specific IgG avidity (HA) were suspected as cases of reinfection and 28 with low MeV-specific IgG (LA) were suspected as cases of primary infection. The viral loads in the HA group were also lower than those in the LA group (p < 0.001). The titers of MeV-specific IgM and IgG in the HA group were significantly lower and higher, respectively, than those in the LA group (p < 0.001). The total LDH and LDH isozyme levels were elevated in the LA group compared with those in the HA group (p < 0.001). Through receiver operating characteristic curve analyses, we determined that the area under the curve of total LDH level was 0.87 (95% confidence interval 0.74-1.00) and that the discriminatory accuracy was high for total LDH and all isozymes. By stepwise binary logistic regression analysis considering MeV-specific IgG avidity, we developed a model using IgG, IgM, and total LDH as explanatory variables, which was optimal for distinguishing the LA and HA groups (adjusted R2 : 0.773, p < 0.001). Thus, the serum LDH level in addition to IgM and IgG may be useful parameters for differentiating MeV reinfection from primary infection. This article is protected by copyright. All rights reserved.

    DOI： 10.1111/1348-0421.13021

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  • 関東地方で初めて感染が確認された重症熱性血小板減少症候群の1例

    平良雅克, 追立のり子, 西嶋陽奈, 太田茉里, 佐藤重紀, 高松由基, 吉河智城, 黒須剛, 下島昌幸, 西條政幸, 立本完吾, 石嶋慧多, 前田健

    IASR (Web)   42 ( 7 )   150 - 152   2021.7

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    Language：Japanese   Publisher：国立感染症研究所  

    J-GLOBAL

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  • 患者病日とリアルタイムPCR Ct値の相関について

    蜂巣 友嗣, 門倉 圭佑, 吉田 智也, 太田 茉里, 藤沼 裕希, 西嶋 陽奈, 追立 のり子, 小川 貴史, 平良 雅克, 竹村 明浩, 佐藤 重紀

    病原微生物検出情報月報   41 ( 7 )   117 - 118   2020.7

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    Language：Japanese   Publisher：国立感染症研究所  

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  • Nationwide Molecular Epidemiology of Measles Virus in Japan Between 2008 and 2017. Reviewed International journal

    Fumio Seki, Masahiro Miyoshi, Tatsuya Ikeda, Haruna Nishijima, Miwako Saikusa, Masae Itamochi, Hiroko Minagawa, Takako Kurata, Rei Ootomo, Jumboku Kajiwara, Takashi Kato, Katsuhiro Komase, Keiko Tanaka-Taya, Tomimasa Sunagawa, Kazunori Oishi, Nobuhiko Okabe, Hirokazu Kimura, Shigeru Suga, Kunihisa Kozawa, Noriyuki Otsuki, Yoshio Mori, Komei Shirabe, Makoto Takeda

    Frontiers in microbiology   10   1470 - 1470   2019

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    Language：English   Publishing type：Research paper (scientific journal)  

    Genotyping evidence that supports the interruption of endemic measles virus (MV) transmission is one of the essential criteria to be verified in achieving measles elimination. In Japan since 2014, MV genotype analyses have been performed for most of the measles cases in prefectural public health institutes nationwide. With this strong molecular epidemiological data, Japan was verified to have eliminated measles in March, 2015. However, even in the postelimination era, sporadic cases and small outbreaks of measles have been detected repeatedly in Japan. This study investigated the nationwide molecular epidemiology of MV between 2008 and 2017. The 891 strains in the total period between 2008 and 2017 belonged to seven genotypes (D5, D4, D9, H1, G3, B3, and D8) and 124 different MV sequence variants, based on the 450-nucleotide sequence region of the N gene (N450). The 311 MV strains in the postelimination era between 2015 and 2017 were classified into 1, 7, 8, and 32 different N450 sequence variants in D9, H1, B3, and D8 genotypes, respectively. Analysis of the detection period of the individual N450 sequence variants showed that the majority of MV strains were detected only for a short period. However, MV strains, MVs/Osaka.JPN/29.15/ [D8] and MVi/Hulu Langat.MYS/26.11/ [D8], which are named strains designated by World Health Organization (WHO), have been detected in many cases over 2 or 3 years between 2015 and 2017. The WHO-named strains have circulated worldwide, causing outbreaks in many countries. Epidemiological investigation revealed repeated importation of these WHO-named strains into Japan. To demonstrate the elimination status (interruption of endemic transmission) in situations with repeated importation of the same strains is challenging. Nevertheless, the detailed sequence analysis of individual MV strains and chronological analysis of these strains provided sufficient evidence to show that Japan has still maintained its measles elimination status in 2017.

    DOI： 10.3389/fmicb.2019.01470

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  • Measles vaccination involved in measles outbreak reported in the Matsudo Health Center district, Chiba Prefecture.

    Haruna Nishijima

    Clinical Virology   2018.3

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    Publishing type：Research paper (scientific journal)  

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  • Prevalence and characteristics of human parechovirus and enterovirus infection in febrile infants. Reviewed International journal

    Kentaro Sano, Hiromichi Hamada, Shoko Hirose, Kenta Sugiura, Satoko Harada, Mai Koizumi, Mayumi Hara, Haruna Nishijima, Masakatsu Taira, Atsushi Ogura, Tomoko Ogawa, Jun-Ichi Takanashi

    Pediatrics international : official journal of the Japan Pediatric Society   60 ( 2 )   142 - 147   2018.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Human parechovirus (HPeV) and human non-polio enterovirus (EV) are important causes of fever without source (FWS) in young infants. Their prevalence and clinical characteristics are largely unknown in Asian countries. This study was conducted to elucidate the epidemiology and clinical characteristics of HPeV and EV infection in febrile young infants in Japan. METHODS: During February 2010-August 2015, we obtained 53 stool, 44 throat swab, and 20 cerebrospinal fluid samples from 56 infants (<3 months) with FWS at a single hospital. To each sample, we applied reverse transcription-polymerase chain reaction for HPeV and EV. We compared the clinical characteristics of HPeV and EV patients. RESULTS: HPeV was detected in 11 and EV in 17 patients. HPeV was detected during July-September. HPeV patients, compared with EV patients, had lower age (32 vs 47 days; P = n.s.), higher prevalence of exclusive breast-feeding (81.8 vs 29.4%; P = 0.024), and lower prevalence of sick contacts (36.4 vs 88.2%; P = 0.010). More HPeV than EV patients met the systemic inflammatory response syndrome criteria (90.9 vs 52.9%; P = 0.049). In the HPeV group, leukopenia, thrombopenia, and elevated deviation enzyme were observed, although the prevalence of abnormal cerebrospinal fluid was significantly lower than in the EV group. HPeV patients had longer hospital stay (7 vs 5 days; P = 0.025). CONCLUSION: HPeV and EV are important causal viruses of FWS. Characteristic clinical pictures exist in these virus infections, but further research is needed to accumulate more cases to produce a comprehensive picture of these virus infections.

    DOI： 10.1111/ped.13467

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  • Coxsackievirus B5 Aseptic Meningitis in Infants in Chiba Prefecture, Japan, in 2016. Reviewed

    Kanae Tsuno, Chiharu Miyatake, Haruna Nishijima, Chiemi Hotta, Tomoko Ogawa, Takeshi Asano

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   85 ( 3 )   187 - 190   2018

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Infantile aseptic meningitis is a rare infection of the central nervous system. Coxsackievirus B5 (CVB5) is an enterovirus that is sometimes associated with aseptic meningitis and encephalitis. CASE PRESENTATION: We report on three isolated infants with aseptic meningitis caused by CVB5 in the spring and summer of 2016 with nearly identical 404-bp CVB5 Viral Capsid Protein 1 (VP1) sequences. In addition, viral analysis of sewage samples from Chiba Prefecture in 2016 showed similar 404-bp CVB5 VP1 sequences from May to September 2016. CONCLUSION: These results indicate that viral screening of sewage water may help detect occult outbreaks of viral infection, particularly for enterovirus strains.

    DOI： 10.1272/jnms.JNMS.2018_85-28

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  • The First Case of Zika Virus Isolated from a Japanese Patient Who Returned to Japan from Fiji in 2016. Reviewed

    Masakatsu Taira, Tomoko Ogawa, Haruna Nishijima, Kojiro Yamamoto, Chiemi Hotta, Mamiko Akita, Shigeru Tajima, Masayuki Saijo

    Japanese journal of infectious diseases   70 ( 5 )   586 - 589   2017.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    Outbreaks of Zika virus (ZIKV) infection in tropical and subtropical regions are a cause of worldwide concern and represent a public health emergency. ZIKV was isolated from a 17-year-old patient with fever and maculopapular rash. The patient returned to Japan from the Republic of Fiji in late April 2016. The complete genome sequence of the ZIKV isolate (ZIKV/Hu/S36/Chiba/2016), which might be the first strain to be isolated in Japan, was identified and reported.

    DOI： 10.7883/yoken.JJID.2017.042

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  • 無菌性髄膜炎患者からのコクサッキーウイルスB群の検出状況―千葉県

    西嶋陽奈 堀田千恵美 平良雅克 秋田真美子 篠崎邦子 小川知子

    IASR (Web)   38 ( 2 )   39 - 40   2017.2

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    Authorship：Lead author  

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  • Detection of Coxsackie Virus Group B in Patients with Aseptic Meningitis - Chiba Prefecture

    Haruna Nishijima

    2017.2

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    Publisher：Infectious Agents Surveillance Report  

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Books

  • 癌診療指針のための病理診断プラクティス 大腸癌

    岩渕三哉, 本間陽奈（ Role： Contributor ,  3章. 病理診断の実際；虫垂の”いわゆるgoblet cell carcinoid”.）

    中山書店  2012.9  （ ISBN:9784521733364 ）

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Presentations

  • THE STRENGTH OF ANTIGEN-ANTIBODY BINDING INFLUENCES THE ROBUSTNESS OF SRID POTENCY

    Haruna Nishijima, Noriko Shimasaki, Tomoko Kuwahara, Yusuke Nakai, Kazuya Nakamura, Kayoko Sato, Keiko Murano, Shigeyuki Itamura, Akihide Ryo, Yuichi Harada

    OPTIONS XII for the Control of INFLUENZA 2024 

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    Event date： 2024.9 - 2024.10

    Language：English   Presentation type：Poster presentation  

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  • An efficient NanoLuciferase-based screening system to identify host proteins interacting with SARS-CoV-2 ORF8

    Haruna Nishijima, Kei Miyakawa, Yuichi Harada, Akihide Ryo

    2023.9 

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    Event date： 2023.9

    Presentation type：Poster presentation  

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  • 抗体結合力（Relative Avidity Index）を指標とした麻疹症例の病態に関する検討

    西嶋陽奈

    第61回日本臨床ウイルス学会  2020 

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    Event date： 2020

    Presentation type：Oral presentation (general)  

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  • ワクチン接種後並びに既感染後の麻疹発症例におけるウイルス量、抗体陽性率、血清LDHの特徴−初感染例との比較検討−

    西嶋陽奈

    第24回日本ワクチン学会学術集会  2020 

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    Event date： 2020

    Presentation type：Oral presentation (general)  

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  • 千葉県麻疹集団発生におけるワクチン接種者の抗体の動き

    西嶋陽奈, 追立のり子, 平良雅克, 堀田千恵美, 小川知子

    第33回関東甲信静支部ウイルス研究部会  2018 

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    Event date： 2018

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  • 関東甲信静ブロックの検査結果報告及び千葉県の検査状況 −麻しん・風しん− Invited

    西嶋陽奈

    平成30年度「地域保健総合推進事業」に係る関東・甲・信・静ブロックレファレンスセンター連絡会議  2018 

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    Event date： 2018

    Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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  • 呼吸器症状を呈した小児科外来患者のボカウイルス重複検出について

    西嶋陽奈, 小倉惇, 堀田千恵美, 平良雅克, 追立のり子, 秋田真美子, 小川知子

    第49回日本小児感染症学会総会・学術集会  2017 

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    Event date： 2017

    Presentation type：Oral presentation (general)  

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  • 夏季を中心とした千葉県内の無菌性髄膜炎の発生について

    西嶋陽奈, 平良雅克, 秋田真美子, 堀田千恵美, 篠﨑邦子, 小川知子

    第37回千葉県小児感染症懇話会  2016 

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    Event date： 2016

    Presentation type：Oral presentation (general)  

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  • 千葉県内で発生した麻疹について

    西嶋陽奈, 平良雅克, 秋田真美子, 堀田千恵美, 篠崎邦子, 小川知子

    第55回千葉県公衆衛生学会  2016 

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    Event date： 2016

    Presentation type：Oral presentation (general)  

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  • インフルエンザ様疾患（ILI）起因ウイルスの動向把握（2014年4月～2015年6月）

    本間陽奈, 小倉惇, 堀田千恵美, 平良雅克, 追立のり子, 秋田真美子, 小川知子, 黒木春郎, 黒崎知道

    第36回千葉県小児感染症懇話会  2015 

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    Event date： 2015

    Presentation type：Oral presentation (general)  

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Awards

  • スタートアップ研究資金

    2025.6   新潟大学若手教員スイングバイ・プログラム

    西嶋陽奈

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  • 特に優れた業績による返還免除制度（全額免除）

    2013   日本学生支援機構   大学院第一種奨学金

    本間陽奈

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  • 年間学業成績優秀者

    2010.5   新潟大学   新潟大学学業成績優秀者奨学金制度

    本間陽奈

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  • 年間学業成績優秀者

    2008.5   新潟大学   新潟大学学業成績優秀者奨学金制度

    本間陽奈

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Research Projects

  • 次世代型プロテオミクスを活用したパンデミックインフルエンザワクチンに対する迅速品質評価法の開発と検証

    2024.4 - 2025.3

    System name：医薬品等規制調和・評価研究事業 医薬品等の品質、有効性、安全性等の評価、分析法等の開発に資する研究

    Awarding organization：国立研究開発法人日本医療研究開発機構

    梁明秀(代表), 原田勇一, 嶋崎典子, 中居佑介, 西嶋陽奈

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  • 発育鶏卵漿尿膜上に確認した鶏TMPRSS2のインフルエンザウイルス活性化能の解析

    Grant number：23K14104

    2023.4 - 2026.3

    System name：科学研究費助成事業 若手研究

    Research category：若手研究

    Awarding organization：日本学術振興会

    西嶋 陽奈

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    Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

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  • 千葉県内で確認した麻疹再感染例におけるウイルス中和抗体の評価

    2020.4 - 2021.4

    System name：大同生命厚生事業団 地域保健福祉研究助成

    西嶋陽奈

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    Authorship：Principal investigator 

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Teaching Experience (researchmap)

 

Social Activities

  • 麻疹(はしか)の今と昔～正しい理解・正しい予防～

    Role(s)： Lecturer

    千葉県衛生研究所 第19回公開講座  2019.1

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Media Coverage

  • 千葉県衛生研究所紹介 TV or radio program

    千葉テレビ  ウィークリー千葉県  2019.2

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