研究者詳細 - 小原　健司

論文 - 小原　健司

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Perianal Abscess Caused by Urethral Foreign Body: A Case Report. 国際誌

Sayaka Hoshino, Kenji Obara, Kazutoshi Yamana, Fumio Ishizaki, Masaki Murata, Tatsuhiko Hoshii, Yoshihiko Tomita

IJU case reports 8 ( 3 ) 249 - 252 2025年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

INTRODUCTION: We report a case of perianal abscess that developed after the presence of a urethral foreign body for 15 months. CASE PRESENTATION: A 14-year-old boy with intellectual disability due to agenesis of the corpus callosum presented to our hospital with complaints of perianal erythema, swelling, and pain. The patient admitted to self-inserting an allene fiber broom ear 15 months ago. A few days after the insertion, he was treated with antibiotics for hematuria and micturition pain. The symptoms resolved spontaneously 2 months later, although the foreign body was not removed. Computed tomography and magnetic resonance imaging demonstrated a perineal linear structure running anterior to posterior. The urethral foreign body was removed by cystourethroscopy and grasper. CONCLUSION: Medical professionals should be aware of the possibility of underlying cognitive and behavioral problems and should be vigilant in screening and treating individuals with refractory lower urinary tract inflammation or hematuria.

DOI： 10.1002/iju5.70017

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Long-term outcomes and prognostic factors of metastatic or recurrent pheochromocytoma and paraganglioma: a 20-year review in a single institution. 国際誌

Fumio Ishizaki, Takahiro Taguchi, Masaki Murata, Sayaka Hoshino, Tomotaka Toba, Keisuke Takeda, Masayuki Tasaki, Kazutoshi Yamana, Takashi Kasahara, Tatsuhiko Hoshii, Kenji Obara, Kazuhide Saito, Yoshihiko Tomita

Scientific reports 14 ( 1 ) 26456 - 26456 2024年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

Pheochromocytoma and paraganglioma (PPGL) represent a group of rare neuroendocrine tumors known for their potential to metastasize. This study provides a comprehensive retrospective evaluation of 15 patients diagnosed with metastatic or recurrent PPGL at our institution over a two-decade span (2000-2020). Our primary objectives were to delineate the long-term clinical outcomes and pinpoint key prognostic determinants. Median duration from initial PPGL diagnosis to the onset of metastasis or recurrence stood at 5.8 years. Predominant sites for metastasis included the bone, lung, lymph nodes, and peritoneum. A salient finding was that surgical interventions targeting metastatic lesions significantly improved prognosis. Further analysis revealed that a Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) exceeding 7 closely associated with unfavorable outcomes. These insights not only underscore the clinical variability of PPGL's progression but also highlight the pivotal role of surgical management for metastatic or recurrent cases. The value of the PASS score as an informative prognostic tool was evident, suggesting its utility in shaping future therapeutic approaches. Given the intricacies of PPGL, collaborative studies involving larger patient cohorts will be crucial to optimize management strategies and prognostication.

DOI： 10.1038/s41598-024-75354-9

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転移または再発褐色細胞腫および傍神経節腫の長期転帰と予後因子単施設での20年間の考察(Long-term Outcomes and Prognostic Factors of Metastatic or Recurrent Pheochromocytoma and Paraganglioma: 20-year review in a single institution)

石崎文雄, 田口貴博, 村田雅樹, 晝間一寿, 田崎正行, 山名一寿, 笠原隆, 星井達彦, 小原健司, 齋藤和英, 冨田善彦

日本内分泌学会雑誌 100 ( 1 ) 425 - 425 2024年5月

Asymptomatic bilateral delayed ureteral obstruction following dextranomer/hyaluronic acid copolymer (Deflux) injection for vesicoureteral reflux.: A case report. 国際誌

Sayaka Hoshino, Kenji Obara, Tatsuhiko Hoshii, Yoshihiko Tomita

Urology case reports 35 101539 - 101539 2021年3月

記述言語：英語

We here present a case of a 4-year-old girl who exhibited an asymptomatic bilateral de novo hydroureteronephrosis seven months after undergoing endoscopic treatment for bilateral vesicoureteral reflux. The child underwent an open bilateral reimplantation. Intraoperatively, a 14 mm nodule on the right and a 16 mm on the left located periureteral orifice were observed. When a small incision was made on nodules, a yellowish-white mucinous fluid flowed out.

DOI： 10.1016/j.eucr.2020.101539

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母のアンドロゲン産生副腎腫瘍により女児外性器の男性化を生じた1例

星野さや香, 小原健司, 星井達彦, 黒木大生, 渡邉和博, 冨田善彦

日本小児泌尿器科学会雑誌 29 ( 2 ) 234 - 234 2020年12月

Virilization of a female infant genitalia caused by a maternal androgen-producing adrenocortical tumor: A case report 査読国際誌

Sayaka Hoshino, Kenji Obara, Tatsuhiko Hoshii, Hiroo Kuroki, Kazuhiro Watanabe, Yoshihiko Tomita

Urology Case Reports 32 101253 - 101253 2020年9月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier BV

A 4-month-old girl presented us with genital ambiguity. The patient had a persistent urogenital sinus, posterior labial fusion with clitoromegaly. MRI reveals ovary-like mass in left inguinal region and right abdominal cavity. Uterus and vagina was also identified. Her mother was diagnosed with a right androgen-producing adrenocortical tumor 14 months after the birth of a virilized infant.

DOI： 10.1016/j.eucr.2020.101253

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Free Tube Graft Urethroplasty for Repair of Hypospadias 査読国際誌

Kenji Obara, Tatsuhiko Hoshii, Sayaka Hoshino, Kazutoshi Yamana, Tsutomu Anraku, Ryo Maruyama, Hiroo Kuroki, Fumio Ishizaki, Hiroyuki Yamazaki, Yoshihiko Tomita

Urologia Internationalis 104 ( 5-6 ) 386 - 390 2020年6月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：S. Karger AG

INTRODUCTION: We aimed to assess the outcome of free tube graft urethroplasty for single-stage repair of hypospadias with chordee in children. MATERIALS AND METHODS: We retrospectively evaluated a series of 56 patients (16 months to 9 years old, median 24 months) who underwent free graft urethroplasty for repair of hypospadias with chordee between May 2005 and November 2017. The median follow-up was 7 years (range 1-11). RESULTS: After releasing the chordee, the hypospadiac orifice was retracted to become penile in 32 patients (57%), penoscrotal in 18 patients (32%), and scrotal in 6 patients (11%). Single-stage repair was achieved without complications in 42 patients (75%). Of the remaining 14 patients with postoperative complications requiring surgical intervention, 2 had meatal stenosis, 9 had urethrocutaneous fistula, 1 had urethral diverticulum without meatal stenosis, and 1 had meatal regression. One patient who complained the urine stream went upwards in an arc underwent cutback meatoplasty to correct the stream. In all patients, a neomeatus with a vertically oriented slit-like appearance was eventually achieved at the tip of the glans. CONCLUSION: A free graft is an appropriate choice for repairing hypospadias with chordee. Our procedure achieved favorable functional and cosmetic outcomes with a low postoperative morbidity rate.

DOI： 10.1159/000504146

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Retrospective Analysis to Determine the Optimal Timing to Discontinue Continuous Antibiotic Prophylaxis in Patients with Primary Vesicoureteral Reflux 査読国際誌

Tsutomu Anraku, Kenji Obara, Masayuki Tasaki, Yoshihiko Tomita

Urologia Internationalis 102 ( 4 ) 462 - 467 2019年6月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：S. Karger AG

BACKGROUND: The management of febrile urinary tract infection (fUTI) in patients with vesicoureteral reflux (VUR) is crucial to prevent renal scarring. Continuous antibiotic prophylaxis (CAP) is the most widely used initial treatment for VUR. However, the optimal duration of CAP is still unclear. We aimed to clarify an appropriate patient population and the optimal timing to discontinue CAP. METHODS: We reviewed the records of 247 patients with primary VUR between January 2000 and December 2015. Seventy-two patients who discontinued CAP despite persistent VUR were enrolled. Kaplan-Meier method and Cox proportional hazard model was used in statistical analysis. RESULTS: Following the discontinuation of CAP, fUTI developed in 25 patients after a median of 9 months (range 0-81). VUR resolved spontaneously in 9 out of 47 patients without recurrence during follow-up. Multivariate analysis showed bilateral VUR and duration of CAP of less than 1 year after the last fUTI were significant risk factors for recurrence. CONCLUSION: Among the risk factors examined, patients administered CAP for less than 1 year after the last fUTI and those with bilateral VUR had significantly more frequent recurrence. Our study suggests that the administration of CAP for more than 1 year after the last fUTI is beneficial in avoiding recurrent fUTI.

DOI： 10.1159/000497312

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後部尿道弁の3症例

星野さや香, 小原健司, 星井達彦, 山名一寿, 冨田善彦

日本小児泌尿器科学会雑誌 28 ( 2 ) 200 - 200 2019年6月

Ulcerative interstitial cystitis in an adolescent successfully treated with complete transurethral ulcer resection: A case report 査読国際誌

Eri Yuki, Kenji Obara, Hiroo Kuroki, Hiroyuki Yamazaki, Kazutoshi Yamana, Akira Tadokoro, Kaede Hiruma, Yoshihiko Tomita

IJU Case Reports 2 ( 1 ) 51 - 53 2019年1月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Wiley

Introduction: Interstitial cystitis is difficult to treat and may affect adolescents. Case presentation: A 15-year-old girl presented with severe pain upon terminal micturition that persisted for approximately 2 hours. The pain had been present for more than 1 month. Cystoscopy revealed severe erosion throughout the trigone. Transurethral fulguration did not improve her symptoms. However, complete electric resection of the ulcer markedly reduced the symptom. After complete resection, pain on urination disappeared and she has had no pain without medication for 15 months. Conclusion: Complete resection not fulguration of the ulcer is effective for interstitial cystitis in adolescent female patients.

DOI： 10.1002/iju5.12038

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/iju5.12038

重複腎盂尿管に伴う異所性尿管瘤に対して経尿道的尿管瘤切開術を施行した症例

小原健司, 星井達彦, 山名一寿, 石崎文雄, 黒木大生, 晝間楓, 結城恵里, 星野さや香, 冨田善彦, 水澤隆樹

日本泌尿器科学会総会 106回 OP - 456 2018年4月

Congenital Scaphoid Megalourethra: A Case Report 査読

Kenji Obara, Hiroyuki Yamazaki, Kazutoshi Yamana, Hiroo Kuroki, Yoshihiko Tomita

Urology Case Reports 14 3 - 4 2017年9月

Angiomyomatous Leiomyoma of a Female Urethral Meatus Recurrence After Seven Years of the Resection: A Case Report 査読国際誌

Tatsuhiko Hoshii, Go Hasegawa, Yohei Ikeda, Shigeko Takaki, Kenji Obara, Tsutomu Nishiyama

Urology Case Reports 9 24 - 26 2016年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier BV

A 20 years old woman had an external urethral orifice mass and received an excision operation. Seven years later, she complained a tumor with pain that was similar to the previous tumor. She underwent the tumor removal. Pathological diagnosis was a urethral angiomyomatous leiomyoma in the new concept of estrogen receptor-positive smooth muscle tumors.

DOI： 10.1016/j.eucr.2016.08.006

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小児原発性膀胱尿管逆流症(VUR)に対する内視鏡的hyaluronic acid/dextranomer注入療法の成績

小原健司, 秋山さや香, 鳥羽智貴, 星井達彦, 瀧澤逸大, 安樂力, 山名一寿, 乾幸平, 冨田善彦

泌尿器外科 29 ( 臨増 ) 890 - 890 2016年5月

Case of Large Cecoureterocele with Contralateral Renal Rupture in Neonate 査読

Kenji Obara, Tsutomu Anraku, Masahiro Ikeda, Shuichi Komatsu, Takaki Mizusawa, Ryo Maruyama, Yoshihiko Tomita

UROLOGIA INTERNATIONALIS 97 ( 2 ) 238 - 240 2016年

尿管瘤に対して内視鏡的瘤切開を施行した症例

小原健司, 池田正博, 白野侑子, 晝間楓, 星井達彦, 瀧澤逸大, 冨田善彦, 水澤隆樹

日本小児泌尿器科学会雑誌 24 ( 2 ) 214 - 214 2015年6月

尿管異所開口による持続性尿失禁を来たした低形成腎に対する後腹膜鏡下腎摘除術の検討

風間明, 西山勉, 小原健司, 星井達彦, 丸山亮, 田所央

Japanese Journal of Endourology 27 ( 3 ) 228 - 228 2014年11月

二分脊椎症による神経因性下部尿路機能障害患者における清潔間欠導尿の尿失禁に対する効果

小原健司, 秋山さや香, 星井達彦, 丸山亮, 田所央

日本排尿機能学会誌 25 ( 1 ) 182 - 182 2014年9月

尿道下裂手術そのゴールは？自然な外観を目指して査読

小原健司

泌尿器外科 27 ( 臨増 ) 673 - 676 2014年

記述言語：日本語出版者・発行元：医学図書出版(株)

Free graft法を用いて尿道下裂修復術を行った症例の外観をHOPEスコアを用いて検討した。Free graft法を用いて尿道下裂修復術を行った19例を対象とした。外尿道口の位置、外尿道口の形態、亀頭の形態、包皮の形態、陰茎捻転の程度、陰茎前屈の程度を術者以外の3例の日本泌尿器科学会専門医が複数の写真セットより判定した。判定結果より外尿道口の形態は縦のスリットであるがスリットか長すぎる傾向があった。また、亀頭形態では外尿道口のスリットの近位に正常な亀頭のブリッジがなくスリットが冠状溝にかかっている症例かみられた。包皮形態では包皮の非対称やたるみが指摘された症例があった。

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当科における異所開口尿管症例の検討

小原健司, 星井達彦, 小松集一, 新井啓, 安藤崇, 結城恵理, 西山勉, 高橋公太

日本泌尿器科学会雑誌 104 ( 2 ) 293 - 293 2013年3月

Free tube graft法による尿道下裂修復術の成績

小原健司, 筒井寿基, 水澤隆樹, 星井達彦, 小松集一, 丸山亮, 新井啓, 原昇, 笠原隆, 石崎文雄, 高橋公太

日本泌尿器科学会雑誌 103 ( 2 ) 520 - 520 2012年3月

A case of true ureteral diverticulum on functional solitary kidney 査読

Tsutomu Anraku, Takaki Mizusawa, Kenji Obara, Hiromi Sato, Yoichi Ajioka, Kota Takahashi

Japanese Journal of Urology 103 ( 3 ) 569 - 572 2012年

The case of retroperitoneoscopic nephrectomy for hypoplastic kidney with ectopic ureter

Yuko Shirono, Takashi Kasahara, Kei Arai, Kenji Obara, Tsutomu Nishiyama, Kota Takahashi

Japanese Journal of Clinical Urology 65 ( 5 ) 323 - 326 2011年4月

Clinical feature of men who benefit from dose escalation of naftopidil for lower urinary tract symptoms: A prospective study 査読

Noboru Hara, Takaki Mizusawa, Kenji Obara, Etsuko Isahaya, Yuki Nakagawa, Kota Takahashi

Advances in Urology 2011年

Efficacy of clean intermittent catheterization（CIC）for urinary incontinence in children with neurogenic bladder dysfunction secondary to myelodysplasia 査読

小原健司

LUTS 2 ( 2 ) 100 - 105 2010年9月

小児の過活動膀胱患者に対するコハク酸ソリフェナシンの使用経験査読

小原健司

小児科臨床 63 ( 9 ) 20272032 2010年

Primitive neuroectodermal tumor of the adrenal gland 査読

Shuichi Komatsu, Ryusuke Watanabe, Masaaki Naito, Takaki Mizusawa, Kenji Obara, Tsutomu Nishiyama, Kota Takahashi

International Journal of Urology 13 ( 5 ) 606 - 607 2006年5月

Role of connective tissue growth factor in fibronectin synthesis in cultured human prostate stromal cells. 国際誌

Kazuya Suzuki, Kenji Obara, Kazuhiro Kobayashi, Kazutoshi Yamana, Vladimir Bilim, Toshiyuki Itoi, Kota Takahashi

Urology 67 ( 3 ) 647 - 53 2006年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: To clarify the correlation of connective tissue growth factor (CTGF) expression and fibronectin (FN) synthesis after transforming growth factor-beta-1 (TGF-beta1) stimulation in human prostate stromal cells. METHODS: Primary cultures of human prostate stromal cells were established from nine normal prostates by the explant method. The gene and protein expressions of CTGF and FN after TGF-beta1 treatment were examined. We also investigated the effect of CTGF blockade on TGF-beta1-induced FN synthesis by CTGF antisense oligodeoxynucleotide treatment. RESULTS: CTGF expression was detected in all nine prostate stromal cells by reverse transcriptase-polymerase chain reaction and immunoblotting. In prostatic tissues, CTGF expression was observed more strongly in epithelial cells than in the stromal area by immunohistochemistry. The upregulation of both CTGF and FN protein by TGF-beta1 treatment was demonstrated in a dose-dependent manner. CTGF antisense oligodeoxynucleotide inhibited TGF-beta1-stimulated FN synthesis. CONCLUSIONS: CTGF plays a crucial role in extracellular matrix production as a TGF-beta1 downstream mediator in human prostate stromal cells, suggesting that CTGF blockade is likely to be a therapeutic target against benign prostatic hyperplasia.

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Obstruction of the ileal ureter by mesenteric vessels occurring 5 years after total ureteral substitution for bilateral ureteral stenosis due to systemic lupus erythematosus 査読

Kazuhiro Kobayashi, Kenji Obara, Ryusuke Watanabe, Noboru Hara, Akiyoshi Katagiri, Kota Takahashi

International Journal of Urology 13 ( 1 ) 80 - 83 2006年1月

Transforming growth factor-β1 regulates cell growth and causes downregulation of SMemb/non-muscle myosin heavy chain B mRNA in human prostate stromal cells 査読

Kenji Obara, Vladimir Bilim, Kazuya Suzuki, Kazuhiro Kobayashi, Noboru Hara, Takashi Kasahara, Tsutomu Nishiyama, Kota Takahashi

Scandinavian Journal of Urology and Nephrology 39 ( 5 ) 366 - 371 2005年

腹腔鏡下骨盤内手術時の術中陰茎海綿体神経モニタリング

小林和博, 西山勉, 車田茂徳, 渡辺竜助, 郷秀人, 黒川公平, 星井達彦, 小原健司, 若月俊二, 谷川俊貴, 高橋公太

日本泌尿器科学会雑誌 95 ( 2 ) 402 - 402 2004年3月

Inducible Nitric Oxide Synthase in Renal Cell Carcinoma: Expression in Tumor Thrombi and Induction under Hypoxic Conditions 査読

Noboru Hara, Vladimir Bilim, Takashi Kasahara, Kenji Obara, Kazuhide Saito, Kota Takahashi, Yoshihiko Tomita

Anticancer Research 23 ( 6 C ) 4641 - 4649 2003年11月

von Hippel-Lindau病に合併した両側褐色細胞腫,異時性両側腎細胞癌の1例

鈴木一也, 小瀬川悦子, 星井達彦, 宮島憲生, 高橋英祐, 渡辺竜助, 小原健司, 冨田善彦, 高橋公太, 吉田実, 矢尾正祐

日本泌尿器科学会雑誌 93 ( 6 ) 710 - 714 2002年9月

記述言語：日本語出版者・発行元：(一社)日本泌尿器科学会

症例は38歳男で,2年9ヶ月前,両側副腎褐色細胞腫に対して副腎切除術を行った.2年4ヶ月前に左腎腫瘍を認め,左腎部分切除術を施行した.病理所見は腎細胞癌で,遺伝子解析ではcodon167番のmissense変異が同定された.8ヶ月前,右腎腫瘍を認めたが,拡張型心筋症に伴う心機能低下のため手術は困難と考え,現在経過観察中である

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2002&ichushi_jid=J01175&link_issn=&doc_id=20021002090008&doc_link_id=110003060635&url=http%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F110003060635&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

[Bilateral pheochromocytomas and asynchronous bilateral renal cell carcinomas associated with von Hippel-Lindau disease: a case report].

Kazuya Suzuki, Etsuko Kosegawa, Tatsuhiko Hoshii, Norio Miyajima, Eisuke Takahashi, Ryusuke Watanabe, Kenji Obara, Yoshihiko Tomita, Kohta Takahashi, Minoru Yoshida, Masahiro Yao

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 93 ( 6 ) 710 - 4 2002年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）

A 38-year-old man who had been followed with diagnosis of dilated cardiomyopathy and retinal angioma was referred to our hospital because of incidentally detected bilateral adrenal masses. Although he was normotensive, levels of catecholamine in urine were elevated and I131-MIBG scintigraphy showed accumulation in bilateral adrenal glands. Screening of central nervous system by MRI revealed cerebellar hemangioblastoma. Right adrenalectomy and left partial adrenalectomy were performed, both of which tumors pathologically diagnosed as pheochromocytoma, followed by resection of the cerebellar hemangioblastoma. Five months later, abdominal CT revealed a left renal tumor and underwent left partial nephrectomy, being diagnosed as renal cell carcinoma. A right renal tumor was detected on follow up CT at 1 year after the partial nephrectomy. Since cardiac function was deteriorated, we have followed with careful observation. This is the second documented case of bilateral renal cell carcinomas and bilateral pheochromocytomas with VHL in Japan.

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Reverse transcription-polymerase chain reaction detection of prostate-specific antigen, prostate-specific membrane antigen, and prostate stem cell antigen in one milliliter of peripheral blood: Value for the staging of prostate cancer 査読

Noboru Hara, Takashi Kasahara, Takashi Kawasaki, Vladimir Bilim, Kenji Obara, Kota Takahashi, Yoshihiko Tomita

Clinical Cancer Research 8 ( 6 ) 1794 - 1799 2002年

Sequential detection of alphafetoprotein-bearing cells in blood stem cell fraction of germ cell tumour patients

T. Kasahara, N. Hara, V. Bilim, Y. Tomita, K. Saito, K. Obara, K. Takahashi

British Journal of Cancer 85 ( 8 ) 1119 - 1123 2001年10月

Frequency of PSA-mRNA-bearing cells in the peripheral blood of patients after prostate biopsy

N. Hara, T. Kasahara, T. Kawasaki, V. Bilim, Y. Tomita, K. Obara, K. Takahashi

British Journal of Cancer 85 ( 4 ) 557 - 562 2001年8月

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