Graduate School of Medical and Dental Sciences Oral Life Science Assistant Professor
Faculty of Dentistry Department of Dentistry Assistant Professor
Updated on 2025/02/19
【Papers】 Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors. 2006.5
【Papers】 Immunoregulatory gene polymorphisms in Japanese women with preterm births and periodontitis. 2012.3
【Papers】 Association of the Fc gamma RIIB-nt645+25A/G polymorphism with the expression level of the Fc gamma RIIb receptor, the antibody response to Porphyromonas gingivalis and the severity of periodontitis 2012.2
博士(歯学) ( 1997.3 新潟大学 )
歯周治療系歯学
Life Science / Conservative dentistry
Niigata University Graduate School of Medical and Dental Sciences Oral Life Science Assistant Professor
2004.4
Niigata University Faculty of Dentistry School of Dentistry Assistant Professor
2004.4
Niigata University University Dental Hospital
1997.10 - 1999.3
Niigata University University Dental Hospital
1989.4 - 1997.9
Niigata University Faculty of Dentistry
- 1987
Niigata University Faculty of Dentistry
- 1987
Country: Japan
日本免疫学会
国際歯科研究学会(IADR)
日本歯周病学会
UCP2 polymorphisms, daily step count, and number of teeth associated with all-cause mortality risk in Sado City: A hospital-based cohort study
Han Lyu, Noriko Sugita, Shigeki Komatsu, Minako Wakasugi, Akio Yokoseki, Akihiro Yoshihara, Tetsuo Kobayashi, Kenji Sato, Hiroyuki Kawashima, Osamu Onodera, Ichiei Narita, Koichi Tabeta
Heliyon 10 ( 12 ) e32512 - e32512 2024.6
佐渡総合病院外来患者における死亡率とUCP2遺伝子多型,歯数および歩数の関連性(UCP2 polymorphisms, teeth number and daily step count associated with mortality in Sado City)
呂 かん, 杉田 典子, 葭原 明弘, 小林 哲夫, 多部田 康一
日本歯周病学会会誌 65 ( 春季特別 ) 135 - 135 2023.4
Association among periodontitis severity, anti-agalactosyl immunoglobulin G titer, and the disease activity of rheumatoid arthritis
Chihiro Kaneko, Tetsuo Kobayashi, Satoshi Ito, Noriko Sugita, Akira Murasawa, Hajime Ishikawa, Koichi Tabeta
Journal of Periodontal Research 2021
抗Porphyromonas gingivalis IgG血清抗体価と肝機能マーカー値および肥満との関連性 佐渡コホートにおける横断研究
高見澤 圭, 杉田 典子, 葭原 明弘, 小林 哲夫, 吉江 弘正, 多部田 康一
新潟歯学会雑誌 50 ( 2 ) 108 - 109 2020.12
Association between serum IgG antibody titers against Porphyromonas gingivalis and liver enzyme levels: A cross-sectional study in Sado Island. International journal
Kei Takamisawa, Noriko Sugita, Shigeki Komatsu, Minako Wakasugi, Akio Yokoseki, Akihiro Yoshihara, Tetsuo Kobayashi, Kazutoshi Nakamura, Osamu Onodera, Takeshi Momotsu, Naoto Endo, Kenji Sato, Ichiei Narita, Hiromasa Yoshie, Koichi Tabeta
Heliyon 6 ( 11 ) e05531 2020.11
Impact of Local Drug Delivery of Minocycline on the Subgingival Microbiota during Supportive Periodontal Therapy: A Randomized Controlled Pilot Study. International journal
Haruna Miyazawa, Takako Nakajima, Makoto Horimizu, Kazuhiro Okuda, Noriko Sugita, Kyoko Yamazaki, Lu Li, Yoshiko Hayashi-Okada, Takuya Arita, Misa Nishimoto, Mieko Nishida, Robert J Genco, Kazuhisa Yamazaki
Dentistry journal 8 ( 4 ) 2020.10
血中肝機能マーカーと抗Porphyromonas gingivalis抗体価の関連性
杉田 典子, 高見澤 圭, 葭原 明弘, 小林 哲夫, 吉江 弘正, 多部田 康一
特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集 152回 148 - 148 2020.6
血清抗Porphyromonas gingivalis IgG抗体価と肝機能マーカー値の関連性 新潟県佐渡市における横断研究
高見澤 圭, 杉田 典子, 葭原 明弘, 小林 哲夫, 吉江 弘正, 多部田 康一
日本歯周病学会会誌 61 ( 秋季特別 ) 130 - 130 2019.10
A polymorphism rs6815464 in the macrophage erythroblast attacher gene is associated with low bone mineral density in postmenopausal Japanese women. Reviewed International journal
Yulan Che, Noriko Sugita, Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura, Hiromasa Yoshie
Gene 700 1 - 6 2019.6
MAEA rs6815464 polymorphism and periodontitis in postmenopausal Japanese females: A cross-sectional study. Reviewed International journal
Yulan Che, Noriko Sugita, Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura, Hiromasa Yoshie
Archives of oral biology 102 128 - 134 2019.6
The number of remaining teeth as a risk indicator of cognitive impairment: A cross-sectional clinical study in Sado Island. Reviewed International journal
Ayumi Kuroki, Noriko Sugita, Shigeki Komatsu, Minako Wakasugi, Akio Yokoseki, Akihiro Yoshihara, Tetsuo Kobayashi, Kazutoshi Nakamura, Takeshi Momotsu, Naoto Endo, Kenji Sato, Ichiei Narita, Hiromasa Yoshie
Clinical and experimental dental research 4 ( 6 ) 291 - 296 2018.12
Increased serum PCSK9, a potential biomarker to screen for periodontitis, and decreased total bilirubin associated with probing depth in a Japanese community survey Reviewed
K. Tabeta, M. Hosojima, M. Nakajima, S. Miyauchi, H. Miyazawa, N. Takahashi, Y. Matsuda, N. Sugita, Y. Komatsu, K. Sato, T. Ishikawa, K. Akiishi, K. Yamazaki, K. Kato, A. Saito, H. Yoshie
Journal of Periodontal Research 53 ( 3 ) 446 - 456 2018.6
Association of liver enzyme levels and alveolar bone loss: A cross-sectional clinical study in Sado Island. Reviewed International journal
Ayumi Kuroki, Noriko Sugita, Shigeki Komatsu, Akio Yokoseki, Akihiro Yoshihara, Tetsuo Kobayashi, Kazutoshi Nakamura, Takeshi Momotsu, Naoto Endo, Kenji Sato, Ichiei Narita, Hiromasa Yoshie
Journal of clinical and experimental dentistry 10 ( 2 ) e100-e106 2018.2
Circulating levels of carbamylated protein and neutrophil extracellular traps are associated with periodontitis severity in patients with rheumatoid arthritis: A pilot case-control study. Reviewed International journal
Chihiro Kaneko, Tetsuo Kobayashi, Satoshi Ito, Noriko Sugita, Akira Murasawa, Kiyoshi Nakazono, Hiromasa Yoshie
PloS one 13 ( 2 ) e0192365 2018
塩酸ミノサイクリン局所投与がサポーティブペリオドンタルセラピー(SPT)期歯周炎患者の歯肉縁下細菌叢に及ぼす影響(第II報)
宮沢 春菜, 中島 貴子, 堀水 慎, 杉田 典子, 奥田 一博, 山崎 和久, Li Lu, Genco Robert
日本歯周病学会会誌 59 ( 秋季特別 ) 190 - 190 2017.11
塩酸ミノサイクリン局所投与がサポーティブペリオドンタルセラピー(SPT)期歯周炎患者の歯肉縁下細菌叢に及ぼす影響(第I報)
中島 貴子, 宮沢 春菜, 堀水 慎, 杉田 典子, 奥田 一博, 山崎 和久, Li Lu, Genco Robert
特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集 147回 195 - 195 2017.10
Relationship between renal function and periodontal disease in community-dwelling elderly women with different genotypes. Reviewed International journal
Akihiro Yoshihara, Noriko Sugita, Masanori Iwasaki, Yanming Wang, Hideo Miyazaki, Hiromasa Yoshie, Kazutoshi Nakamura
Journal of clinical periodontology 44 ( 5 ) 484 - 489 2017.5
PPARγ gene polymorphism, C-reactive protein level, BMI and periodontitis in post-menopausal Japanese women. Reviewed International journal
Yangming Wang, Noriko Sugita, Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura, Hiromasa Yoshie
Gerodontology 33 ( 1 ) 44 - 51 2016.3
The Interaction Between β-3 Adrenergic Receptor and Peroxisome Proliferator-Activated Receptor Gamma Gene Polymorphism to Periodontal Disease in Community-Dwelling Elderly Japanese. Reviewed International journal
Akihiro Yoshihara, Noriko Sugita, Masanori Iwasaki, Yanming Wang, Hideo Miyazaki, Hiromasa Yoshie, Kazutoshi Nakamura
Journal of periodontology 86 ( 8 ) 955 - 63 2015.8
Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women Reviewed
Y. Hanai, N. Sugita, Y. Wang, A. Yoshihara, M. Iwasaki, H. Miyazaki, K. Nakamura, H. Yoshie
Archives of Oral Biology 60 ( 4 ) 533 - 539 2015
杉田典子, 中曽根直弘, 花井悠貴, 高橋昌之, 伊藤晴江, 両角俊哉, 久保田健彦, 奥田一博, 吉江弘正
日本歯科保存学雑誌 57 ( 3 ) 219 - 228 2014.6
The interaction between beta-3 adrenergic receptor polymorphism and obesity to periodontal disease in community-dwelling elderly Japanese. Reviewed International journal
Akihiro Yoshihara, Noriko Sugita, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura
Journal of clinical periodontology 41 ( 5 ) 460 - 6 2014.5
Profiling biomarkers in gingival crevicular fluid using multiplex bead immunoassay. Reviewed International journal
Yasuko Shimada, Koichi Tabeta, Noriko Sugita, Hiromasa Yoshie
Archives of oral biology 58 ( 6 ) 724 - 30 2013.6
Peroxisome proliferator-activated receptor (PPAR) γ polymorphism, vitamin d, bone mineral density and periodontitis in postmenopausal women Reviewed
Y. Wang, N. Sugita, A. Yoshihara, M. Iwasaki, H. Miyazaki, K. Nakamura, H. Yoshie
Oral Diseases 19 ( 5 ) 501 - 506 2013
Effects of the Tooth Gel "Jellcoat F" on Residual Periodontal Pockets after Periodontal Therapy
OKADA Takayuki, SUGITA Noriko, OTSUKA Akemi, AOKI Yuka, TAKAHASHI Masayuki, YOSHIE Hiromasa
The Japanese Journal of Conservative Dentistry 56 ( 4 ) 344 - 352 2013
FcγRIIB-nt645+25A/G gene polymorphism and periodontitis in Japanese women with preeclampsia Reviewed
Y. Wang, N. Sugita, A. Kikuchi, R. Iwanaga, E. Hirano, Y. Shimada, J. Sasahara, K. Tanaka, H. Yoshie
International Journal of Immunogenetics 39 ( 6 ) 492 - 500 2012.12
Immunoregulatory gene polymorphisms in Japanese women with preterm births and periodontitis. Reviewed International journal
Noriko Sugita, Tetsuo Kobayashi, Akira Kikuchi, Yasuko Shimada, Emi Hirano, Jun Sasahara, Kenichi Tanaka, Hiromasa Yoshie
Journal of reproductive immunology 93 ( 2 ) 94 - 101 2012.3
The association of Aggregatibacter actinomycetemcomitans with preeclampsia in a subset of Japanese pregnant women. Reviewed International journal
Emi Hirano, Noriko Sugita, Akira Kikuchi, Yasuko Shimada, Jun Sasahara, Ruriko Iwanaga, Kenichi Tanaka, Hiromasa Yoshie
Journal of clinical periodontology 39 ( 3 ) 229 - 38 2012.3
Association of the Fc gamma RIIB-nt645+25A/G polymorphism with the expression level of the Fc gamma RIIb receptor, the antibody response to Porphyromonas gingivalis and the severity of periodontitis Reviewed
N. Sugita, R. Iwanaga, T. Kobayashi, H. Yoshie
JOURNAL OF PERIODONTAL RESEARCH 47 ( 1 ) 105 - 113 2012.2
FcγRIIB polymorphisms, periodontitis and preterm birth in Japanese pregnant women Reviewed
R. Iwanaga, N. Sugita, E. Hirano, J. Sasahara, A. Kikuchi, K. Tanaka, H. Yoshie
Journal of Periodontal Research 46 ( 3 ) 292 - 302 2011.6
The effect of periodontal treatment on serum leptin, interleukin-6, and C-reactive protein. Reviewed International journal
Yasuko Shimada, Yasutaka Komatsu, Ikuyo Ikezawa-Suzuki, Hideaki Tai, Noriko Sugita, Hiromasa Yoshie
Journal of periodontology 81 ( 8 ) 1118 - 23 2010.8
Peroxisome proliferator-activated receptor gamma polymorphism and periodontitis in pregnant Japanese women. Reviewed International journal
Emi Hirano, Noriko Sugita, Akira Kikuchi, Yasuko Shimada, Jun Sasahara, Ruriko Iwanaga, Kenichi Tanaka, Hiromasa Yoshie
Journal of periodontology 81 ( 6 ) 897 - 906 2010.6
Antibody responses to Porphyromonas gingivalis outer membrane protein in the first trimester. Reviewed International journal
Jun Sasahara, Akira Kikuchi, Koichi Takakuwa, Noriko Sugita, Yoshimitsu Abiko, Hiromasa Yoshie, Kenichi Tanaka
The Australian & New Zealand journal of obstetrics & gynaecology 49 ( 2 ) 137 - 41 2009.4
Iwanaga Ruriko, Hirano Emi, Sugita Noriko, Yoshie Hiromasa
Program and Abstracts of Annual Meeting of the Japanese Society of Periodontology 2009 28 - 28 2009
Lower antibody response to Porphyromonas gingivalis associated with immunoglobulin G Fc gamma receptor IIB polymorphism Reviewed
Y. Honma, N. Sugita, T. Kobayashi, Y. Abiko, H. Yoshie
JOURNAL OF PERIODONTAL RESEARCH 43 ( 6 ) 706 - 711 2008.12
The interleukin-1 and Fcgamma receptor gene polymorphisms in Japanese patients with rheumatoid arthritis and periodontitis. Reviewed International journal
Tetsuo Kobayashi, Satoshi Ito, Takeshi Kuroda, Kouji Yamamoto, Noriko Sugita, Ichiei Narita, Takayuki Sumida, Fumitake Gejyo, Hiromasa Yoshie
Journal of periodontology 78 ( 12 ) 2311 - 8 2007.12
The Fc gamma RIIa polymorphism influences production of interleukin-1 by mononuclear cells Reviewed
K. Yamamoto, T. Kobayashi, N. Sugita, H. Tai, H. Yoshie
INTERNATIONAL JOURNAL OF IMMUNOGENETICS 34 ( 5 ) 369 - 372 2007.10
The combined genotypes of stimulatory and inhibitory Fc gamma receptors associated with systemic lupus erythematosus and periodontitis in Japanese adults. Reviewed International journal
Tetsuo Kobayashi, Satoshi Ito, Keiko Yasuda, Takeshi Kuroda, Kouji Yamamoto, Noriko Sugita, Hideaki Tai, Ichiei Narita, Fumitake Gejyo, Hiromasa Yoshie
Journal of periodontology 78 ( 3 ) 467 - 74 2007.3
Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors. Reviewed International journal
Jiquan Zhang, Anna Raper, Noriko Sugita, Ravi Hingorani, Mariolina Salio, Michael J Palmowski, Vincenzo Cerundolo, Paul R Crocker
Blood 107 ( 9 ) 3600 - 8 2006.5
FcgammaRIIIb genotypes and smoking in periodontal disease progression among community-dwelling older adults in Japan. Reviewed International journal
Akihiro Yoshihara, Noriko Sugita, Kouji Yamamoto, Tetsuo Kobayashi, Toshinobu Hirotomi, Hiroshi Ogawa, Hideo Miyazaki, Hiromasa Yoshie
Journal of periodontology 76 ( 2 ) 250 - 5 2005.2
Alterations of gene expression in human neutrophils induced by smoking cessation. Reviewed International journal
Toshiya Morozumi, Takehiko Kubota, Noriko Sugita, Manami Itagaki, Hiromasa Yoshie
Journal of clinical periodontology 31 ( 12 ) 1110 - 6 2004.12
Risk of periodontitis in systemic lupus erythematosus is associated with Fcgamma receptor polymorphisms. Reviewed International journal
Tetsuo Kobayashi, Satoshi Ito, Kouji Yamamoto, Hisashi Hasegawa, Noriko Sugita, Takeshi Kuroda, Susumu Kaneko, Ichiei Narita, Keiko Yasuda, Masaaki Nakano, Fumitake Gejyo, Hiromasa Yoshie
Journal of periodontology 74 ( 3 ) 378 - 84 2003.3
Differential gene expression in neutrophils from patients with generalized aggressive periodontitis Reviewed
T Kubota, T Morozumi, K Shimizu, N Sugita, T Kobayashi, H Yoshie
JOURNAL OF PERIODONTAL RESEARCH 36 ( 6 ) 390 - 397 2001.12
The Fcγ Receptor Genotype as a Severity Factor for Chronic Periodontitis in Japanese Patients. Reviewed International journal
Tetsuo Kobayashi, Kouji Yamamoto, Noriko Sugita, W-Ludo van der Pol, Keiko Yasuda, Susumu Kaneko, Jan G J van de Winkel, Hiromasa Yoshie
Journal of periodontology 72 ( 10 ) 1324 - 1331 2001.10
Analysis of vitamin D and Fcγ receptor polymorphisms in Japanese patients with generalized early-onset periodontitis Reviewed
A. Yoshihara, N. Sugita, K. Yamamoto, T. Kobayashi, H. Miyazaki, H. Yoshie
Journal of Dental Research 80 ( 12 ) 2051 - 2054 2001
The Fcγ receptor genotype as a severity factor for chronic periodontitis in Japanese patients Reviewed
T. Kobayashi, K. Yamamoto, N. Sugita, W. L. Van Der Pol, K. Yasuda, S. Kaneko, J. G.J. Van De Winkel, H. Yoshie
Journal of Periodontology 72 ( 10 ) 1324 - 1331 2001
The Fcγ receptor genotype as a risk factor for generalized early-onset periodontitis in Japanese patients Reviewed
Tetsuo Kobayashi, Noriko Sugita, W.-Ludo Van Der Pol, Yasuko Nunokawa, Nomdo A.C. Westerdaal, Kouji Yamamoto, Jan G.J. Van De Winkel, Hiromasa Yoshie
Journal of Periodontology 71 ( 9 ) 1425 - 1432 2000
Relevance of FcγRIIIa-158V/F polymorphism to recurrence of adult periodontitis in Japanese patients Reviewed
Noriko Sugita, Kouii Yamamoto, Tetsuo Kobayashi, Hiromasa Yoshie, Kohji Hara, W.-Ludo Van Der Poi, Jan G.J. Van DE WINKEL, Tsuneyoshi Horigome
Japanese Journal of Clinical Immunology 21 225 - 234 1998
PRESENCE OF ACTIVATED EOSINOPHILS, HIGH IGE AND SCD23 TITERS IN GINGIVAL CREVICULAR FLUID OF PATIENTS WITH ADULT PERIODONTITIS Reviewed
T SUZUKI, N SUGITA, H YOSHIE, K HARA
JOURNAL OF PERIODONTAL RESEARCH 30 ( 3 ) 159 - 166 1995.5
OHTAKE Tohru, TAKANO Tokiko, KURIHARA Chikako, MINAMIZAKI Nobuki, MIYASHITA Hajime, HASEGAWA Kohji, SUGITA Noriko, SATOH Etsuko, TAI Hideaki, KOBAYASHI Tetsuo, YOSHIE Hiromasa, HARA Kohji, ISODA Ryuutaro, KAWAI Toshihisa, SAHO Teruyuki, OGO Shuuji, MIKI Yasuo, OKADA Hiroshi
Journal of the Japanese Association of Periodontology 33 ( 1 ) 154 - 163 1991.3
SUGITA Noriko, SATOH Etsuko, TAI Hideaki, KOBAYASHI Tetsuo, YOSHIE Hiromasa, HARA Kohji, OHTAKE Tohru, TAKANO Tokiko, KURIHARA Chikako, MINAMIZAKI Nobuki, MIYASHITA Hajime, HASEGAWA Kohji, ISODA Ryuutaro, KAWAI Toshihisa, SAHO Teruyuki, OGO Shuuji, MIKI Yasuo, OKADA Hiroshi
Journal of the Japanese Association of Periodontology 33 ( 1 ) 164 - 171 1991.3
Duration patterns of percussion sound in healthy and periodontally affected teeth Reviewed
S. TAGUCHI, N. SUGITA, Y. ASAZUMA, K. HARA
Journal of Oral Rehabilitation 17 ( 6 ) 579 - 585 1990
OHTAKE Tohru, SAKURAI Chisato, KURIHARA Chikako, MINAMIZAKI Nobuki, KOBAYASHI Makoto, MIYASHITA Hajime, HASEGAWA Kohji, KOBAYASHI Tetsuo, SATOH Etuko, SUGITA Noriko, OKUDA Kazuhiro, YANAGIMURA Mitsuhiro, YOSHIE Hiromasa, HARA Kohji
JOURNAL OF THE JAPANESE ORGANISATION FOR RESEARCH OF PERIODONTOLOGY 32 ( 1 ) 241 - 248 1990
KOBAYASHI Tetsuo, SATOH Etsuko, SUGITA Noriko, OKUDA Kazuhiro, YANAGIMURA Mitsuhiro, YOSHIE Hiromasa, HARA Kohji, SAKURAI Chisato, KURIHARA Chikako, MINAMIZAKI Nobuki, OHTAKE Tohru, KOBAYASHI Makoto, MIYASHITA Hajime, HASEGAWA Kohji
JOURNAL OF THE JAPANESE ORGANISATION FOR RESEARCH OF PERIODONTOLOGY 32 ( 1 ) 249 - 260 1990
抗Porphyromonas gingivalis IgG血清抗体価と肝機能マーカー値および肥満との関連性-佐渡コホートにおける横断研究-
高見澤圭, 杉田典子, 葭原明弘, 小林哲夫, 小林哲夫, 吉江弘正, 多部田康一
新潟歯学会雑誌 50 ( 2 ) 2020
β2-Microglobulin and Neutrophil Gelatinase-Associated Lipocalin, Potential Novel Urine Biomarkers in Periodontitis: A Cross-Sectional Study in Japanese. Reviewed International journal
Mayuka Nakajima, Michihiro Hosojima, Koichi Tabeta, Sayuri Miyauchi, Miki Yamada-Hara, Naoki Takahashi, Haruna Miyazawa, Yumi Matsuda-Matsukawa, Keisuke Sato, Noriko Sugita, Yasutaka Komatsu, Tomomi Ishikawa, Kazuhiro Akiishi, Kazuhisa Yamazaki, Kiminori Kato, Akihiko Saito, Hiromasa Yoshie
International journal of dentistry 2019 1394678 - 1394678 2019
血清抗Porphyromonas gingivalis IgG抗体価と肝機能マーカー値の関連性-新潟県佐渡市における横断研究-
高見澤圭, 杉田典子, 葭原明弘, 小林哲夫, 小林哲夫, 吉江弘正, 多部田康一
日本歯周病学会会誌(Web) 61 2019
日本人成人において血中肝機能マーカー高値と歯槽骨吸収度との間に関連性は見られるか? 横断研究
黒木 歩, 杉田 典子, 葭原 明弘, 小林 哲夫, 吉江 弘正, 若杉 三奈子, 横関 明男, 中村 和利, 成田 一衛, 遠藤 直人, 小松 繁樹, 百都 健, 佐藤 賢治
新潟歯学会雑誌 47 ( 2 ) 116 - 116 2017.12
歯周炎と血液・尿中バイオロジカルマーカーとの関連解析
中島麻由佳, 中島麻由佳, 多部田康一, 宮内小百合, 杉田典子, 小松康高, 本田朋之, 高橋直紀, 宮澤春菜, 有松圭, 皆川高嘉, 松田由実, 松田由実, 佐藤圭祐, 佐藤圭祐, 山崎和久, 吉江弘正
日本歯科保存学会学術大会プログラムおよび講演抄録集(Web) 143rd P126 (WEB ONLY) - 197 2015.11
久保田健彦, 冨田尊志, 濃野要, 阿部大輔, 清水太郎, 杉田典子, 金子昇, 根津新, 川島昭浩, 坪井洋, 佐々木一, 吉江弘正
日本歯科保存学雑誌 58 ( 2 ) 109 - 116 2015.4
ホエイペプチド配合流動食による歯周炎患者GCF中の炎症性サイトカインへ与える影響
久保田健彦, 冨田尊志, 阿部大輔, 清水太郎, 濃野要, 金子昇, 杉田典子, 川島昭浩, 坪井洋, 佐々木一, 吉江弘正
日本歯科保存学会学術大会プログラムおよび講演抄録集(Web) 140th P85 (WEB ONLY) 2014.6
歯周炎患者における塩酸クロルヘキシジンおよびCPC配合洗口液の抗菌作用
杉田典子, 中曽根直弘, 花井悠貴, 高橋昌之, 伊藤晴江, 両角俊哉, 久保田健彦, 奥田一博, 吉江弘正
日本歯周病学会学術大会プログラムおよび講演抄録集 56th 121 2013.9
6 関節リウマチと歯周炎の感受性に関連する遺伝子多型(I.一般演題,第8回新潟ゲノム医学研究会)
小林 哲夫, 伊藤 聡, 黒田 毅, 山本 幸司, 杉田 典子, 成田 一衛, 住田 孝之, 下条 文武, 吉江 弘正
新潟医学会雑誌 122 ( 12 ) 692 - 692 2008.12
Association between FcγRIIB genotype and antibody response against Porphyromonas gingivalis
HONMA Yuko, SUGITA Noriko, KOBAYASHI Tetsuo, ABIKO Yoshimitu, YOSHIE Hiromasa
48 181 - 181 2006.3
8 抑制性Fcγレセプター(FcγRIIB)遺伝子多型と歯周炎・SLE感受性との関連(I.一般演題,第5回新潟ゲノム医学研究会)
小林 哲夫, 安田 桂子, 伊藤 聡, 杉田 典子, 黒田 毅, 山本 幸司, 成田 一衛, 下条 文武, 吉江 弘正
新潟医学会雑誌 119 ( 11 ) 697 - 697 2005.11
4 FcγRIIB遺伝子多型と歯周炎感受性との関連性(第4回新潟ゲノム医学研究会)
安田 桂子, 杉田 典子, 小林 哲夫, 山本 幸司, 吉江 弘正
新潟医学会雑誌 118 ( 12 ) 713 - 713 2004.12
Fc gamma RIIB gene polymorphisms in Japanese periodontitis patients
K Yasuda, N Sugita, T Kobayashi, K Yamamoto, H Yoshie
GENES AND IMMUNITY 4 ( 8 ) 541 - 546 2003.12
IgA receptor gene polymorphism in Japanese periodontitis patients.
S. Kaneko, T. Kobayashi, K. Yamamoto, N. Sugita, H. Yoshie
JOURNAL OF DENTAL RESEARCH 82 B362 - B362 2003.6
KOBAYASHI Tetsuo, YAMAMOTO Kouji, SUGITA Noriko, YASUDA Keiko, KANEKO Susumu, YOSHIE Hiromasa
45 58 - 58 2002.10
Association of Fc_γRIIB Genotype with Risk of Aggressive Periodontitis
Yasuda Keiko, Sugita Noriko, Yamamoto Kouji, Kobayashi Tetsuo, Yoshie Hiromasa
Journal of the Japanese Association of Periodontology 44 144 - 144 2002.9
FcγRIIB Polymorphisms in Patients with Chronic Periodontitis
Yasuda Keiko, Sugita Noriko, Yamamoto Kouji, Kobayashi Tetsuo, Yoshie Hiromasa
Journal of the Japanese Association of Periodontology 44 83 - 83 2002.3
Fcγ Receptor Polymorphism sin Systemic Lupus Erythematosus and Aggressive Periodontitis
Kobayashi Tetsuo, Yamamoto Kouji, Sugita Noriko, Yasuda Keiko, Kaneko Susumu, Yoshie Hiromasa
Journal of the Japanese Association of Periodontology 44 85 - 85 2002.3
Mutational analysis of the Fcα Receptor gene in Japanese patients with periodontitis
Kaneko Susumu, Yamamoto Kouji, Kobayashi Tetsuo, Sugita Noriko, Yoshie Hiromasa
Journal of the Japanese Association of Periodontology 44 84 - 84 2002.3
Fcg receptor polymorphisms in systemic lupus erythematosus and chronic periodontitis.
K Yamamoto, T Kobayashi, S Ito, N Sugita, H Hasegawa, T Kuroda, S Kaneko, Narita, I, K Yasuda, M Nakano, F Gejyo, H Yoshie
JOURNAL OF DENTAL RESEARCH 81 A368 - A368 2002.3
Seven single nucleotide substitutions in human Fcg receptor IIB gene.
N Sugita, K Yasuda, K Yamamoto, T Kobayashi, H Yoshie
JOURNAL OF DENTAL RESEARCH 81 A313 - A313 2002.3
Seven single nucleotide substitutions in human Fc gamma receptor IIB gene
K Yasuda, N Sugita, K Yamamoto, T Kobayashi, H Yoshie
TISSUE ANTIGENS 58 ( 5 ) 339 - 342 2001.11
5)SLE・歯周炎感受性とFcγR遺伝子多型(一般演題, 新潟ゲノム医学研究会)
杉田 典子, 小林 哲夫, 山本 幸司, 金子 進, 安田 桂子, 吉江 弘正, 伊藤 聡, 長谷川 尚, 黒田 毅, 成田 一衛, 中野 正明, 下条 文武
新潟医学会雑誌 115 ( 10 ) 544 - 544 2001.10
Fcγ Receptor Polymorphism in Systemic Lupus Erythematosus and Chronic Periodontitis
Yamamoto Kouji, Kobayashi Tetsuo, Sugita Noriko, Kaneko Susumu, Yasuda Keiko, Yoshie Hiromasa
Journal of the Japanese Association of Periodontology 43 101 - 101 2001.9
Effective in vitro clearance of Porphyromonas gingivalis by Fc alpha receptor I (CD89) on gingival crevicular neutrophils
T Kobayashi, K Yamamoto, N Sugita, AB van Spriel, S Kaneko, JGJ van de Winkel, H Yoshie
INFECTION AND IMMUNITY 69 ( 5 ) 2935 - 2942 2001.5
Evidence for a novel polymorphism affecting both N-linked glycosylation and ligand binding of the IgG receptor IIIB (CD16)
K Yamamoto, N Sugita, T Kobayashi, K Okuda, JGJ van de Winkel, H Yoshie
TISSUE ANTIGENS 57 ( 4 ) 363 - 366 2001.4
Differential mRNA expression in neutrophils from patients with generalized early-onset periodontitis
Morozumi Toshiya, Kubota Takehiko, Shimizu Kunihiko, Sugita Noriko, Kobayashi Tetsuo, Yoshie Hiromasa
Journal of the Japanese Association of Periodontology 43 ( 0 ) 145 - 145 2001.3
Relevance of Fcγ Receptor Polymorphisms to-Severity of Adult Periodontitis in Japanese Patients
Kobayashi Tetsuo, Yamamoto Kouji, Sugita Noriko, Yasuda Keiko, Kaneko Susumu, Yoshie Hiromasa
Journal of the Japanese Association of Periodontology 43 79 - 79 2001.3
Increased frequency of Fc gamma RIIIb-NA1 allele in periodontitis-resistant subjects in an elderly Japanese population
N Sugita, T Kobayashi, Y Ando, A Yoshihara, K Yamamoto, JGJ van de Winkel, H Miyazaki, H Yoshie
JOURNAL OF DENTAL RESEARCH 80 ( 3 ) 914 - 918 2001.3
Differential gene expression in neutrophils from patients with generalized aggressive periodontitis
Takehiko Kubota, Toshiya Morozumi, Kunihiko Shimizu, Noriko Sugita, Tetsuo Kobayashi, Hiromasa Yoshie
Journal of Periodontal Research 36 ( 6 ) 390 - 397 2001
Toshiya Morozumi, Takehiko Kubota, Noriko Sugita, Yutaka Ohsawa, Kazuhisa Yamazaki, Hiromasa Yoshie
Journal of Periodontal Research 36 ( 3 ) 160 - 168 2001
Immunotherapy of periodontitis with bispecific antibodies : 1. Identification of target Fc receptor
Kobayashi Tetsuo, Yamamoto Kouji, Sugita Noriko, Kaneko Susumu, Yoshie Hiromasa
Journal of the Japanese Association of Periodontology 42 165 - 165 2000.9
The Fcγ Receptor Genotype as a Risk Factor for Generalized Early-Onset Periodontitis in Japanese Patients. Reviewed International journal
Tetsuo Kobayashi, Noriko Sugita, W-Ludo van der Pol, Yasuko Nunokawa, Nomdo A C Westerdaal, Kouji Yamamoto, Jan G J Van De Winkel, Hiromasa Yoshie
Journal of periodontology 71 ( 9 ) 1425 - 1432 2000.9
A novel PCR-based method for direct Fc gamma receptor IIIa (CD163) allotyping
FGJ Leppers-van de Straat, WL van der Pol, MD Jansen, N Sugita, H Yoshie, T Kobayashi, JGJ van de Winkel
JOURNAL OF IMMUNOLOGICAL METHODS 242 ( 1-2 ) 127 - 132 2000.8
SUGITA Noriko, KOBAYASHI Tetsuo, YAMAMOTO Kouji, MIYAZAWA Hideo, YOSHIE Hiromasa
Journal of the Japanese Association of Periodontology 42 68 - 68 2000.4
Yamamoto Kouji, Sugita Noriko, Kobayashi Tetsuo, Okuda Kazuhiro, Yoshie Hiromasa
Journal of the Japanese Association of Periodontology 42 67 - 67 2000.4
Relevance of IgG receptor IIIb (CD16) polymorphism to handling of Porphyromonas gingivalis: implications for the pathogenesis of adult periodontitis
T Kobayashi, WL van der Pol, JGJ van de Winkel, K Hara, N Sugita, NAC Westerdaal, H Yoshie, T Horigome
JOURNAL OF PERIODONTAL RESEARCH 35 ( 2 ) 65 - 73 2000.4
Differential mRNA Expression of Human Neutrophils induced by LPS from P.gingivalis
Morozumi Toshiya, Kubota Takehiko, Sugita Noriko, Ohsawa Yutaka, Yamazaki Kazuhisa, Yoshie Hiromasa
Journal of the Japanese Association of Periodontology 41 ( 0 ) 129 - 129 1999.9
Fcγ Receptor Polymorphisms in Patients with Early-Onset Periodontitis
Kobayashi Tetsuo, Sugita Noriko, Pol W-Ludo van der, Nunokawa Yasuko, Westerdaal Nomdo A.C., Yamamoto Kouji, Winkel Jan G.J. van de, Yoshie Hiromasa
Journal of the Japanese Association of Periodontology 41 67 - 67 1999.9
Relevance of Fc gamma RIIIa-158V-F polymorphism to recurrence of adult periodontitis in Japanese patients
N Sugita, K Yamamoto, T Kobayashi, WL Van der Pol, T Horigome, H Yoshie, JGJ Van de Winkel, K Hara
CLINICAL AND EXPERIMENTAL IMMUNOLOGY 117 ( 2 ) 350 - 354 1999.8
Relevance of Fcγ Receptor IIIb Polymorphism to Neutrophil Handling of Porphromonas gingivalis
Kobayashi Tetsuo, van der Pol W-Ludo, Sugita Noriko, Westerdaal Nomdo A.C., Yoshie Hiromasa, Horigome Tsuneyoshi, van de Winkel Jan G.J., Hara Kohji
Journal of the Japanese Association of Periodontology 41 84 - 84 1999.3
Relevance of FcγRIIIa-158V/F polymorphism to recurrence of adult periodontitis in Japanese patients
SUGITA Noriko, YAMAMOTO Kouji, KOBAYASHI Tetsuo, VAN DER POL W.-Ludo, HORIGOME Tsuneyoshi, YOSHIE Hiromasa, VAN DE WINKEL Jan G.J., HARA Kohji
Journal of the Japanese Association of Periodontology 40 61 - 61 1998.9
Activation of transcription factors and IL-8 expression in neutrophils stimulated with lipopolysaccharide from Porphyromonas gingivalis
N Sugita, A Kimura, Y Matsuki, T Yamamoto, H Yoshie, K Hara
INFLAMMATION 22 ( 3 ) 253 - 267 1998.6
Sugita Noriko, Kimura Asako, Matsuki Yutaka, Yamamoto Tadashi, Yoshie Hiromasa, Hara Kohji
Journal of the Japanese Association of Periodontology 39 147 - 147 1997.3
Yoshie Hiromasa, Miyazaki Akira, Tai Hideaki, Sugita Noriko, Hara Kohji
Journal of the Japanese Association of Periodontology 39 141 - 141 1997.3
Characterization of complement receptor type 1 and type 3 mRNA expression on polymorphonuclear leucocytes (neutrophils) in gingival crevicular fluid from periodontitis-affected patients
N Sugita, Y Matsuki, H Yoshie, K Hara
ARCHIVES OF ORAL BIOLOGY 42 ( 2 ) 113 - 120 1997.2
Decreased expression of CR1 and CR3 mRNA on PMNs in GCF
N Sugita, Y Matsuki, T Suzuki, H Yoshie, K Hara
JOURNAL OF DENTAL RESEARCH 75 685 - 685 1996
Role of Immunocompetent and Host-defensive Cells on Periodontal Disease
Hara Kohji, Sugita Noriko, Aoyagi Toshihiko, Suda Satoru
Journal of the Japanese Association of Periodontology 38 ( 3 ) 243 - 260 1996
Role of Immunocompetent and Host-defensive Cells on Periodontal Disease.
Kohji Hara, Noriko Sugita, Toshihiko Aoyagi, Satoru Suda
Journal of the Japanese Society of Periodontology 38 ( 3 ) 243 - 260 1996
Decreasd Expression of CR1 and CR3 mRNA on PMN in GCF
SUGITA Noriko, MATSUKI Yutaka, YOSHIE Hiromasa, HARA Kohji
Journal of the Japanese Association of Periodontology 37 122 - 122 1995.9
KOBAYASHI Tetsuo, TAI Hideaki, SUGITA Noriko, HARA Kohji
Journal of the Japanese Association of Periodontology 36 90 - 90 1994.3
DIFFERENTIAL EXPRESSION OF CR3, FC-EPSILON-RII AND FC-GAMMA-RIII ON POLYMORPHONUCLEAR LEUKOCYTES IN GINGIVAL CREVICULAR FLUID
N SUGITA, T SUZUKI, H YOSHIE, N YOSHIDA, M ADACHI, K HARA
JOURNAL OF PERIODONTAL RESEARCH 28 ( 5 ) 363 - 372 1993.9
Sugita Noriko, Ofuji Yasuto, Suzuki Takashi, Yoshie Hiromasa, Hara Kohji, Yoshida Naoko, Kanatani Kazushi, Adachi Masakazu
Journal of the Japanese Association of Periodontology 33 98 - 98 1991.8
Sugita Noriko, Ofuji Yasuto, Suzuki Takashi, Yoshie Hiromasa, Hara Kohji, Hirata Ichiro, Kanatani Kazushi, Yoshida Naoko, Adachi Masakazu
Journal of the Japanese Association of Periodontology 33 119 - 119 1991.4
A Rapid Diagnosis (SK-013) for Periodontitis Based on Enzymatic Activity of Periodontopathic Bacteria : Diagnostic Value of SK-013
ISODA Ryuutaro, KAWAI Toshihisa, SAHO Teruyuki, OGO Shuuji, MIKI Yasuo, OKADA Hirosi, KURIHARA Chikako, TAKANO Tokiko, MINAMIZAKi Nobuki, OHTAKE Tohru, MIYASHITA Hajime, HASEGAWA Kohji, SUGITA Noriko, SATOH Etsuko, TAI Hideaki, KOBAYASHI Tetsuo, YOSHIE Hiromasa, HARA Kohji
Journal of the Japanese Association of Periodontology 32 125 - 125 1990.10
A Rapid Diagnisis (SK-013) for Periodontitis Based on Enzymatic Activity of Periodontopathic Bacteria : The Judgement on the Effect of Periodontal Pocket Curettage by SK-013
SUGITA Noriko, SATOH Etsuko, TAI Hideaki, KOBAYASHI Tetsuo, YOSHIE Hiromasa, HARA Kohji, KURIHARA Chikako, TAKANO Tokiko, MINAMIZAKi Nobuki, OHTAKE Tohru, MIYASHITA Hajime, HASEGAWA Kohji, ISODA Ryuutaro, KAWAI Toshihisa, SAHO Teruyuki, OGO Shuuji, MIKI Yasuo, OKADA Hiroshi
Journal of the Japanese Association of Periodontology 32 126 - 126 1990.10
A Rapid Diagnosis (SK-013) for Periodontitis Based on Enzymatic Activity of Periodontopathic Bacteria : Clinical Specificity of SK-013
KURIHARA Chikako, TAKANO Tokiko, MINAMIZAKI Nobuki, OHTAKE Tohru, MIYASHITA Hajime, HASEGAWA Kohji, ISODA Ryuutaro, KAWAI Toshihisa, SAHO Teruyuki, OGO Shuuji, MIKI Yasuo, OKADA Hiroshi, SUGITA Noriko, SATOH Etsuko, TAI Hideaki, KOBAYASHI Tetsuo, YOSHIE Hiromasa, HARA Kohji
Journal of the Japanese Association of Periodontology 32 124 - 124 1990.10
The Effect of Occlusal Interferences caused by Full Cast Crown on Occlusal Sound
ASAZUMA Yatsuo, SODEYAMA Takao, SUGITA Noriko, TAGUCHI Satoshi, HARA Kohji, WATANABE Kiyoshi
Journal of the Japanese Association of Periodontology 31 118 - 118 1989.9
A Rapid Diagnosis for Periodontitis Based on the Enzymatic Activity Derived from Periodontopathic Bacteria : 4. Examination of Diagnostic Parameters
OHTAKE T., SAKURAI C., HANAOKA C., MINAMIZAKI N., KOBAYASHI M., MIYASHITA H., HASEGAWA K., KOBAYASI T., SATOU E., SUGITA N., OKUDA K., YANAGIMURA M., YOSHIE H., HARA K.
Journal of the Japanese Association of Periodontology 31 127 - 127 1989.9
A Rapid Diagnosis for Periodontitis Based on the Enzymatic Activity Derived from Periodontopathic Bacteria. (SK-013) : 5. The Judgment on the Effect of Initial Preparation
KOBAYASHI Tetsuo, SATOH Etsuko, SUGITA Noriko, OKUDA Kazuhiro, YANAGIMURA Mitsuhiro, YOSHIE Hiromasa, HARA Kohji, SAKURAI Chisato, HANAOKA Chikako, MINAMIZAKI Nobuki, OHTAKE Tohru, KOBAYASHI Makoto, MIYASHITA Hajime, HASEGAWA Kohji
Journal of the Japanese Association of Periodontology 31 128 - 128 1989.9
Sound Duration from the Teeth with Periodontal Disease on Percussion by Occlusal Sound Analyzer
TAGUCHI Satoshi, SUGITA Noriko, ASAZUMA Yatsuo, HARA Kohji
Journal of the Japanese Association of Periodontology 31 137 - 137 1989.4
Sound Duration from the Teeth with Periodontal Disease on Percussion by Occlusal Sound Analyzer
TAGUCHI Satoshi, SUGITA Noriko, ASAZUMA Yatsuo, HARA Kohji
Proceeding of Japanese Society of Stomatognathic Function 8 51 - 54 1989
口腔および口蓋扁桃マイクロバイオームが慢性腎臓病に及ぼす包括的メカニズムの解明
Grant number:22K10337
2022.4 - 2025.3
System name:科学研究費助成事業
Research category:基盤研究(C)
Awarding organization:日本学術振興会
葭原 明弘, 成田 一衛, 杉田 典子, 宮本 茜, 諏訪間 加奈, 新美 奏恵
Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )
Analysis of the mechanisms underlying the link between periodontitis and rheumatoid arthritis onset and deterioration: the potential role of glycan modification of autoantibody
Grant number:21K09891
2021.4 - 2025.3
System name:Grants-in-Aid for Scientific Research
Research category:Grant-in-Aid for Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )
エネルギー代謝調節遺伝子UCPは握力と歯周炎および全身疾患の関連性に関与する
Grant number:21K09871
2021.4 - 2024.3
System name:科学研究費助成事業
Research category:基盤研究(C)
Awarding organization:日本学術振興会
杉田 典子
Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )
我々はこれまでに筋組織に多く存在し様々な疾患との関連が報告される脱共役タンパク(Uncoupling protein; UCP)について、歯周炎とUCP遺伝子多型の関連性を疫学研究で報告し、UCPによる歯周炎への関与を細胞実験にて明らかにしてきた。UCPの関与する筋力の指標である握力レベルと死因別死亡リスクとの関連性が久山スタディにて報告されている。そこで本研究では、UCP遺伝子多型と握力・全身疾患・歯周炎の関連性を疫学的に解析し、またその分子メカニズムを細胞実験、動物実験で検討することとした。
2008年開始の臓器連関研究コホートプロジェクトであるPROST(Project in Sado for Total health)に参加した新潟県佐渡市佐渡総合病院の外来患者について歯科データおよび全身疾患を含む医科データと血液から採取したDNAを利用することにつき、新潟大学遺伝子倫理委員会に申請し承認を得た。このうち1750名についてはJaponica Arrayによる遺伝型解析済みであるため、それに含まれるUCP2遺伝子多型rs659366の遺伝型タイピング結果を利用することとし、同様に新潟大学遺伝子倫理委員会の承認を得た。しかしPROST参加者において現状では握力データを有する者が少なく、COVIC-19の影響下で新たに握力測定を追加できるペースは極めて遅くなっていることから、解析可能な人数が集まるまで長期的に待つ必要がある。一方でUCPは運動により発現が増強し、また運動習慣および歯数はそれぞれ死亡リスク低下に関連するとの報告があることから、運動習慣を表すデータとして1日平均歩数を用いて解析することにした。現在これらのデータを有するPROST参加者915名について歩数および歯数と死亡リスクおよび全身疾患との関連性、それに対するUCP2遺伝子多型の影響を解析中である。
Uncoupling protein gene polymorphisms associated with severe periodontitis in Japanese adults
Grant number:18K09572
2018.4 - 2021.3
System name:Grants-in-Aid for Scientific Research
Research category:Grant-in-Aid for Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
Sugita Noriko
Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )
Uncoupling proteins (UCP) are mitochondrial membrane transporters which regulate energy expenditure and the metabolism of lipids and carbohydrates. UCP2 is expressed in a broad range of cells including immune cells. UCP3 is expressed in skeletal muscle cells and spleen. We have previously reported associations between the UCP gene polymorphisms and severe periodontitis in postmenopausal women. In vitro study revealed that UCP2 attenuated production of reactive oxygen species and proinflammatory cytokines. In this study, we validated the associations in another Japanese adult population.All outpatients of Sado General Hospital were invited to participate in a cohort study. The final subjects were composed of 115 men and 100 women (mean age 67 years). Edentulous person and participants with missing data were excluded. Adjusted for age, sex, diabetes, body mass index and smoking, the UCP2 rs659366 and the UCP3 rs2075577 were significantly associated with severe periodontitis.
歯周組織および口蓋扁桃の病態からみた慢性腎臓病に対する多角的発症メカニズムの解明
Grant number:18H03013
2018.4 - 2021.3
System name:科学研究費助成事業 基盤研究(B)
Research category:基盤研究(B)
Awarding organization:日本学術振興会
葭原 明弘, 成田 一衛, 宮崎 秀夫, 杉田 典子
Grant amount:\17160000 ( Direct Cost: \13200000 、 Indirect Cost:\3960000 )
地域疫学研究においては、新潟大学大学院医歯学総合研究科健康増進医学分野で実施されている「うおぬま地方の健康調査」メタボリックドミノ進展要因として食生活と身体活動の与える影響の解明を目的とした新潟県魚沼圏域住民/健診ベースのデータや生体試料を使用し、分析を行うこととした。2018年度、60歳代の男性で喫煙していない810人を対象にした。P.g.に対する血漿抗体価を測定し、歯周病の状態を表す指標とした。p.g.抗体価を3分位に分類した後分析を進めた。その結果、現在歯数とP.g.抗体価とはU字カーブ用の関連が認められた。同様に尿中クレアチニンや尿中尿素窒素ともU字カーブ用の関連が認められた。また、P.g.抗体価を従属変数、腎機能関連5項目を独立変数とし重回帰分析を実施したところ、クレアチニンクレアランスはP.g.抗体価と有意な関連が認められた(p=0.025)。一方、臨床疫学研究では、腎・膠原病内科、および歯周病科との打ち合わせが終了後、新潟大学の倫理審査委員会の承認を得た。その後、歯周組織および口蓋扁桃組織の細菌数の測定方法の確立を目指した。IgA腎症患者3例について口蓋扁桃組織における細菌数を測定したところ、全細菌数のうち、red complexの占める割合は0~3.47%であった。また、関連調査では、β3-adrenergic receptor genotypeと歯周病との関連をみると肥満者や喫煙経験が長い人の方がgenotypeの影響が強く出ていた。
地域疫学研究におけるP.g.抗体価とU字用カーブを示す理由についてはさらに分析を進める必要がある。また、口蓋扁桃組織におけるred complexの占める割合は0~3.47%であったことについては分析の際に周囲の口蓋扁桃の生体組織が多く含まれている可能性が考えられた。今後さらに分析方法を検討する必要がある。
Uncoupling protein genes associated with periodontitis, diabetes, obesity and osteoporosis in postmenopausal women
Grant number:15K11384
2015.4 - 2018.3
System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Research category:Grant-in-Aid for Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
Sugita Noriko, NAKAMURA KAZUTOSHI
Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )
Uncoupling proteins (UCPs) are mitochondrial membrane transporters which regulate the metabolism of carbohydrate, lipid, and bone. Genetic polymorphisms in UCPs are risk factors for diabetes, obesity and osteoporosis. Periodontitis has been reported to be associated with the systemic diseases. Therefore, we investigated the associations among UCP polymorphisms, periodontitis, diabetes, obesity and osteoporosis. As a result, UCP2 and UCP3 polymorphisms were associated with severe periodontitis independently of the systemic diseases, though the prevalence of periodontitis was not associated with the polymorphisms. Moreover, to elucidate the biological role of UCP2 in periodontitis, we performed experiments in human macrophages. The suppression of UCP2 expression significantly elevated the levels of reactive oxygen species and proinflammatory cytokines. The results suggested that UCPs may play roles in the pathogenesis of periodontitis.
Associations between PPARgamma gene polymorphism and periodontitis, obesity and osteoporosis in postmenopausal women
Grant number:24593121
2012.4 - 2015.3
System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Research category:Grant-in-Aid for Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
SUGITA Noriko, NAKAMURA Kazutoshi
Grant amount:\5330000 ( Direct Cost: \4100000 、 Indirect Cost:\1230000 )
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear hormone receptor and regulates inflammation, lipid and bone metabolism. Previous studies reported associations between polymorphisms in PPARgamma gene and inflammation, obesity and osteoporosis. Postmenopausal women have higher risks for these diseases. Therefore, to elucidate whether PPARgamma Pro12Ala polymorphism was a common risk factor for the diseases, we assessed possible associations between the genotypes and parameters of obesity, osteoporosis and periodontitis in 359 postmenopausal Japanese women living in Niigata City. As a result, the Ala allele carriage was suggested to enhance associations between periodontitis and obesity or osteoporosis. The finding might contribute to risk diagnosis and suggest possible effects of PPARgamma regulation in therapies of these diseases.
Peroxisome proliferator-activated receptor gamma polymorphism andperiodontitis, preterm birth and obesity in pregnant Japanese women
Grant number:21659480
2009 - 2011
System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
Research category:Grant-in-Aid for Challenging Exploratory Research
Awarding organization:Japan Society for the Promotion of Science
YOSHIE Hiromasa, SUGITA Noriko, KIKUCHI Akira
Grant amount:\3180000 ( Direct Cost: \3000000 、 Indirect Cost:\180000 )
PPAR gamma is a nuclear hormone receptor which regulates lipid metabolism and production of inflammatory cytokines. A functional genetic polymorphism Pro12Ala has been reported. Recent studies have suggested an association between periodontitis and preterm birth or obesity. We investigated relationships between PPAR gamma polymorphism, periodontitis, preterm birth and obesity in pregnant Japanese women. There was no significant association between periodontitis and preterm birth, or between periodontitis and obesity. However, a significant association of the polymorphism and periodontitis was found in the Japanese pregnant women.
Polymorphisms for immunoregulatory genes in women with preterm birth and periodontitis
Grant number:19592385
2007 - 2008
System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Research category:Grant-in-Aid for Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
SUGITA Noriko
Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )
Immune regulation by the inhibitory IgG receptor related to the susceptibility of periodontitis
Grant number:17592159
2005 - 2006
System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Research category:Grant-in-Aid for Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
SUGITA Noriko, KOBAYASHI Tetsuo
Grant amount:\3300000 ( Direct Cost: \3300000 )
Human low affinity Fc receptor IIb (FcγRIIb) is one of IgG receptors and suppress the activation of B lymphocytes through cross-linking with B cell receptor (BCR) via immune-complexes. This function of FcγRIIb is essential for the negative regulation of antibody productions. Our previous study has demonstrated the gene polymorphism FcγRIIB-I232T to be significantly associated with periodontitis. In this study, we examined the possibility that IgG antibody responses to periodontopathic bacteria Porphyromonas gingivalis (P.gingivalis) are different between periodontitis patients with different genotypes. Forty-seven patients with periodontitis were genotyped for FcγRIIB-I232T with the direct sequencing of genome DNA. Serum levels of nonspecific total IgG and specific IgG subclasses for the sonicate of P.gingivalis, the recombinant 40-kDa outer membrane protein (OMP) and 200kDa antigenic protein (AP) were determined. FcγRIIB-232T carrier revealed significantly lower IgG2 response to P.gingivalis 40-kDa OMP compared to noncarrier (P<0.05). Lower responses of FcγRIIB-232T carrier were also observed in specific IgG and IgG1 levels which were not statistically significant. No significant difference of antibody response to P.gingivalis sonicate or 200-kDa AP was observed between FcγRIIB-232T carrier and noncarrier. In FcγRIIB-232T noncarrier, there was a subgroup of patients showing high levels of IgG2 response in concert with the high average of probing depth. In contrast, all FcγRIIB-232T carriers revealed lower levels of IgG2 response. These results suggest that the association of FcγRIIB-232T allele with periodontitis might be attributed to the lower level of antibody response to P.gingivalis.
We investigated the expression of FcγRIIb in peripheral blood leukocytes and gingiva from periodontitis patients. Expression levels of FcγRIIb on B lymphocytes were lower in patients with periodontitis compared to controls. This might be a cause of less effective inhibition of overactivation of B lymphocytes in the pathogenesis of periodontitis. Expression of FcγRIIb was also confirmed in human gingiva with periodontitis.
Determination of common risk genes associated with periodontitis and autoimmune disease
Grant number:15390644
2003 - 2005
System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Research category:Grant-in-Aid for Scientific Research (B)
Awarding organization:Japan Society for the Promotion of Science
KOBAYASHI Tetsuo, SUGITA Noriko, YAMAMOTO Kouji
Grant amount:\14500000 ( Direct Cost: \14500000 )
To identify common risk genes associated with periodontitis and autoimmune disease, we have evaluated the distributions of the genotypes of the immunoglobulin Fc receptors (FcR) and inflammatory cytokines such as interleukin-1 (IL-1) in patients with both diseases. Our results were as follows :
1.A significant association was found between FcγRIIA gene and periodontitis and autoimmune disease, as demonstrated by a case-control study with 213 chronic periodontitis patients, 87 patients with systemic lupus erythematosus (SLE), and 209 controls. These results were supported by a functional study showing a difference in IL-1 production between the FcγRIIA genotypes.
2.FcγRIIB nt 775T/C was shown to be a candidate common risk polymorphism associated with both diseases by a case-control study with 58 chronic periodontitis patients, 66 SLE patients, and 44 controls. This FcγRIIB genotype has been suggested to regulate antibody response specific for Porphyromonas gingivalis 40 kDa outer membrane protein.
3.IL-1B +3954 was shown as a gene related to onset of rheumatoid arthritis (RA) by an association study with 140 chronic periodontitis patients, 50 aggressive periodontitis patients, 46 RA patients, and 149 controls.
Bone homeostasis-related genes associated with susceptibility to periodicities
Grant number:13470461
2001 - 2003
System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Research category:Grant-in-Aid for Scientific Research (B)
Awarding organization:Japan Society for the Promotion of Science
YOSHIE Hiromasa, YAMAZAKI Kazuhisa
Grant amount:\16500000 ( Direct Cost: \16500000 )
Vitamin D receptor (VDR), Tumor necrosis factor alpha (TNF-α), TNF receptor, Interleukin-1 (IL-1), IL-1 receptor antagonist (IL-1RA), and CD14 had been reported to be related with bone homeostasis and were selected as candidate genes in this study. Association between polymorphisms in the candidate genes and susceptibility to aggressive or chronic periodontitis were assessed in case-control studies. Genotypes were determined using genomic DNA obtained from Japanese patients and healthy controls.
In Japanese subjects, the polymorphism in the 5'-flanking region of TNF-α gene was not associated with susceptibility to generalized aggressive periodontitis (G-AgP), whereas the combination of genotypes of VDR and IgG receptor, FcγRIIIb, and VNTR (variable number of tandem repeats) in IL-1RA gene showed significant associations with the susceptibility to G-AgP. Single nucleotide polymorphisms (SNPs) in TNFR1 and FcγRIIb genes were associated with G-AgP, respectively. A polymorphism in CD14 gene was not related to the development of periodontitis, but suggested to be related to early disease activity.
These analyses demonstrated that a number of genes related to bone homeostasis were relevant with the development of periodontitis as combinatorial factors. The findings in this study may be useful for a diagnosis system with multiple genetic factors of periodontitis.
Genetic diagnosis and immunoglobulin A receptor targeting therapy for periodontitis
Grant number:13557189
2001 - 2003
System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Research category:Grant-in-Aid for Scientific Research (B)
Awarding organization:Japan Society for the Promotion of Science
KOBAYASHI Tetsuo, SUGITA Noriko
Grant amount:\11700000 ( Direct Cost: \11700000 )
-1.Genetic diagnosis of periodontisis risk :
Sequence analyses of immunoglobulin A and G Fc receptor (neutrophil-specific FcαRI, CD89 and B cell-specific FcγRIIB, CD32) indicated one and seven single-nucleotide substitutions, respectively. Of these polymorphisms, FcαRI nt 324A/G and FcγRIIB nt 775T/C have been shown to be associated with aggressive periodontitis risk. Neutrophils (PMN) from peripheral blood and gingival crevicular fluid (GCF) of periodontitis patients exhibited a decreased phagocytosis in the nt 324 A/A as compared to the nt 324 G/G patients. These results suggest FcαRI nt 324A/A patients to be high-susceptibility to aggressive periodontitis.
-2.Immunoglobulin A receptor targeting therapy :
The bispecific antibody (BsAb) was constructed from anti-Porphyromonas gingivalis and anti-FcαRI monoclonal antibody (MAb). Flow cytometric analyses showed opsonic activity for GCF PMN to be comparable between BsAb and control anti-P. gingivalis MAb. However, a BsAb significantly promoted phagocytosis and killing activity of GCF PMN, which exhibiting higher FcαRI expression levels than PB PMN. These data suggest BsAb targeting toward GCF PMN FcαRI to be effective for improvement of antibacterial immunity in periodontitis patients.
Fc receptor gene analysis and immunotherapy with bispecific antibody for periodontal disease
Grant number:12557191
2000 - 2002
System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Research category:Grant-in-Aid for Scientific Research (B)
Awarding organization:Japan Society for the Promotion of Science
YOSHIE Hiromasa, SUGITA Noriko, KOBAYASHI Tetsuo
Grant amount:\10300000 ( Direct Cost: \10300000 )
- Diagnosis of periodontisis risk with Fc receptor gene polymorphisms :
The association of FcR polymorphisms with severity of chronic periodontitis (CP) was examined by means of allele-specific polymerase chain reactions. A significant over-representation of FcRIIIa-158V allele in severe CP patients as compared to moderate AP patients (P = 0.03). In addition, we found a strong association between CP severity and FcR composite genotype comprising FcRIIIA-158V plus FcRIIIB-NA2 (odds ratio 4.7, P = 0.002). The association study consisted of 60 SLE patients, age-matched 42 healthy subjects with periodontitis, and 42 healthy subjects without periodontitis indicated FcγRIIa-R131 allele to be a common risk factor for SLE and periodontitis. Variation screening of neutrophil-specific FcRIIIB and B cell-specific FcRIIB genes showed new one and seven single nucleotide polymorphisms, respectively, and documented the association of FcRIIB nt 775T/C with aggressive periodontitis risk. These results suggest FcR genotype to be associated with susceptibility to periodontitis.
- Immunotherapy of periodontitis with human monoclonal antibody :
Human immunoglobulin (Ig)-producing mice were immunized by intraperitoneal injection of recombinant 40-kDa outer membrane protein (r40-kDa OMP) of Porphyromonas gingivalis. Total 99 clones of human monoclonal antibodies (hMAb) specific for r40-kDa OMP were obtained, all of which was IgG isotype (IgG1 : 84 clones ; IgG2 : 11 clones ; IgG4 : 4 clones). The binding activity of hMAb to r40-kDa OMP was shown to be almost same as that of human polyclonal antibody (60 times higher in concentration). The opsonophagocytic activity of hMAb clones were also indicated to be almost same as that of human polyclonal antibody (10000 times higher in concentration). This hMAb was shown to enhance neutrophil phagocytosis of P. gingivalis.
Inhibitory IgG receptor as an immunoregulator and a relevant factor for periodontitis susceptibility
Grant number:12672033
2000 - 2002
System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Research category:Grant-in-Aid for Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
KOBAYASHI Tetsuo, SUGITA Noriko
Grant amount:\3300000 ( Direct Cost: \3300000 )
FcγRIIB as an immunoregulator :
The inhibitory IgG receptor, FcγRIIB was genetically examined to clarify its role as an immunoregulator. FcγRIIB nucleotide sequence was screened on genomic DNA isolated from peripheral blood of 100 healthy donors with informed consent by means of direct sequencing. We identified 5 and 2 single nucleotide substitutions in exon 4 and intron 4, respectively. Of these, 3 substitutions indicated amino acid changes, which might correspond to the potential splicing sites. However, no change of splicing in the FcγRIIB transcripts was identified with the determination of cDNA sequence. These substitutions located in the extracellular IgG binding domain might induce the structural change of FcγRIIB.
FcγRIIB as a relevant factor for periodontitis susceptibility
We have determined FcγRIIB genotypes for the exon 4 and intron 4, as well as exon 5 bi-allelic polymorphisms in 33 aggressive periodontitis (AGP) patients, 73 chronic periodontitis (CP) patients, and 71 healthy controls, with informed consent, by means of direct sequencing or polymerase chain reaction. Our results indicated a significant over-representation of the nt 775 C allele in the AGP group compared with the control group (AGP vs. Control : 17% vs. 6% ; P=0.01, Odds ratio 3.4), suggesting FcγRIIB gene to be a candidate factor associated with susceptibility to periodontitis.
Development of Immunotherapy of Refractory Periodontitis with Anti-Fc Receptor Bispecific Antibodies
Grant number:12672032
2000 - 2001
System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Research category:Grant-in-Aid for Scientific Research (C)
Awarding organization:Japan Society for the Promotion of Science
KOBAYASHI Tetsuo, SUGITA Noriko
Grant amount:\3100000 ( Direct Cost: \3100000 )
After informed consent was obtained, gingival crevicular fluid (GCF)- and peripheral blood (PB)-neutrophils (PMN) from 21 adult periodohtitis patients were analyzed for their IgG and IgA PcR (FcγR and FcαR) expression and function by studying IgG- and IgA-mediated elimination of Porphyromonas gingivalis. GCF-PMN exhibited increased FcαR levels and decreased FcγR levels compared to PB-PMN. Functional studies revealed GCF-PMN to exhibit a decreased capacity to phagocytose and kill IgG1-opsonized P.gingivalis compared to PB-PMN. IgA1-mediated phagocytosis and killing capacity was, however, comparable between GCF- and PB-PMN. These results suggest FcαR to represent a candidate target for FcR-directed immunotherapy of periodontitis.
Recombinant 40-kDa outer membrane protein (rOMP-40) of P. gingivalis was obtained by purification with homogeneity from the cell sonicate. Human immunoglobulin producing mice, KM mouse^<TM>, were immunized by injection of rOMP-40. The spleen cells were collected, and then fused with the mouse myeloma cell line. Total 102 clones of human mononlonal antibodies (hMAbs) specific for rOMP-40 were obtained and screened by enzyme-linked immunosorbent assay. The number of IgG was 99, whereas three were IgM. IgA clone was not established. The opsonophagocytic activity of hMAb clones showing high reactivity with rOMP-40 was measured. Our results indicated hMAb clones to be significantly higher in opsonophagocytic activity than human polyclonal antibodies. These results provided the possibility that topical application of hMAbs would be aid in PMN-dependent elimination of P. gingivalis.
Immunoglobulin receptors as genetic risk factors of periodontitis
Grant type:Competitive
歯周炎感受性に関わるリスク遺伝子としてのイムノグロブリンレセプターの研究
Grant type:Competitive
生涯にわたる歯と咬合
一般口腔保健管理学II
歯周病学
臨床実習Ⅰ
総合模型実習
臨床実習Ⅲ
歯科衛生学実習Ⅱ
臨床実習Ⅱ
早期臨床実習ⅠB
早期臨床実習Ⅱ
早期臨床実習Ⅰ
選択実習Ⅱ
臨床予備実習
歯周病学実習