Updated on 2026/07/04

写真a

 
CHINUSHI Masaomi
 
Organization
Academic Assembly Institute of Medicine and Dentistry Health Sciences Professor
Faculty of Medicine School of Health Sciences Medical Technology Professor
Title
Professor
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Degree

  • 医学博士 ( 1993.3   新潟大学 )

Research Interests

  • 心臓植込みデバイス

  • 抗不整脈薬

  • 心臓電気生理

  • カテーテルアブレーション

  • 不整脈

Research Areas

  • Life Science / Cardiology

Research History

  • Niigata University   Faculty of Medicine School of Health Sciences Medical Technology   Professor

    2014.4

  • Niigata University   Faculty of Medicine School of Health Sciences   Associate Professor

    2004.4 - 2014.3

  • Niigata University   Graduate School of Health Sciences Health Sciences   Associate Professor

    2004.4 - 2014.3

  • Niigata University   Graduate School of Health Sciences Health Sciences   Associate Professor

    2004.4 - 2014.3

  • Niigata University   Faculty of Medicine   Lecturer

    1999.11 - 2000.5

  • Niigata University   University Medical Hospital   Research Assistant

    1998.6 - 1999.1

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Professional Memberships

  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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  • JAPANESE HEART RHYTHM SOCIETY

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  • The Japanese Circulation Society

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  • JAPANESE ASSOCIATION OF CARDIOVASCULAR INTERVENTION AND THERAPEUTICS

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  • 日本高血圧学会

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Papers

  • Impedance decrement indexes for avoiding steam‐pop during bipolar radiofrequency ablation: An experimental study using a dual‐bath preparation International journal

    Osamu Saitoh, Ayaka Oikawa, Ayari Sugai, Masaomi Chinushi

    Journal of Cardiovascular Electrophysiology   31 ( 12 )   3302 - 3310   2020.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    INTRODUCTION: This experimental study was conducted to explore impedance monitoring for safely performing bipolar (BIP) radiofrequency (RF) ablation targeted to arrhythmia focus. METHODS AND RESULTS: Using a newly designed dual-bath experimental model, contact-force-controlled (20-g) BIP ablation (50 W, 60 s) was attempted for porcine left ventricle (17.0 ± 2.7 mm thickness). BIP ablation was successfully accomplished for 60 s in 75 of the 89 RF applications (84.3%), whereas audible steam-pop occurred in the other 14 RF applications (15.7%). Receiver operating characteristic analysis demonstrated the optimal predictive values regarding the occurrence of steam-pop as follows; thinner myocardial wall (≤14.8 mm), low minimum impedance (≤89 ohm), greater total impedance decrement (TID) (≤ -25 ohm) and %TID (≤ -22.5%). Greater impedance decrement was not observed immediately preceding the occurrence of steam-pop but appeared around 15 s before. Four steam-pops happened before reaching the optimal predictive values of minimum impedance, whereas all 14 steam-pops developed 11.5 ± 9.2 and 8.1 ± 8.1 s after reaching the optimal predictive values of TID and %TID, respectively. Total lesion depth (endocardial plus epicardial) was 10.7 ± 1.2 mm on average, and was well correlated with TID and %TID. Transmural lesion through the myocardial wall was created in 22 RF applications. CONCLUSION: Relatively thinner areas of the myocardium are likely to be at greater risk for steam-pop during BIP RF ablation. Lowering the RF application energy to reduce the impedance decrement may help to lessen this risk.

    DOI： 10.1111/jce.14764

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  • Patient-by-patient basis anti-tachycardia pacing for fast ventricular tachycardia with structural heart diseases. Reviewed International journal

    Masaomi Chinushi, Hiroshi Furushima, Osamu Saitoh, Takashi Noda, Takashi Nitta, Yoshifusa Aizawa, Tohru Ohe, Takashi Kurita

    Pacing and clinical electrophysiology : PACE   43 ( 9 )   983 - 991   2020.6

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    BACKGROUND: Anti-tachycardia pacing (ATP) delivered from an implantable device is an important tool to terminate ventricular tachycardia (VT). But its real-world efficacy for fast VT has not been fully studied. METHODS: Using the database of Nippon-storm study, effect of patient-by-patient basis ATP programming for fast VT (≥ 188 bpm) was assessed for the patients with structural heart diseases. Fast VTs were divided into three groups depending on HR; Group-A was 188-209 bpm, and Group-B and Group-C were 210-239 bpm and ≥ 240 bpm, respectively. RESULTS: During a median follow-up of 28 months, 202 fast VT episodes (209±19 bpm) were demonstrated in the 85 patients. ATP terminated 151 of the 202 episodes (74.8%) in total. The success rate of the ATP was not different among the three groups; 73.3% in Group-A, 80.6% in Group-B and 66.7% in Group-C. ATP success rate of more than 50% and more than 70% was 77.6% and 64.7% of the patients, respectively. LVEF was significantly higher in the patients with rather than without successful ATP therapy, and ROC analysis revealed that LVEF of 23% was the optimal cut-off value. ATP was less effective in patients taking amiodarone, but etiology of the structural heart diseases, indication of the device implantation and all ECG parameters were not useful predictors for successful ATP therapy. CONCLUSIONS: ATP highly terminated fast VT with wide HR-ranges in patients with structural heart diseases, and should be considered as the first line therapy for fast VT except for patients with very low LVEF. This article is protected by copyright. All rights reserved.

    DOI： 10.1111/pace.13980

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  • Bepridil Inhibits Premature Ventricular Complexes Induced by Cardio-Sympathetic Nerve Stimulation in a Canine Experimental Model. Reviewed

    Osamu Saitoh, Junya Watanabe, Ayari Sugai, Ayaka Oikawa, Mika Sugai, Masaomi Chinushi

    International heart journal   61 ( 2 )   338 - 346   2020.3

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    Sympathetic nerve activity has arrhythmogenic potential for ventricular arrhythmias associated with structural heart diseases. However, a sufficient amount of beta-blockers occasionally cannot be prescribed in some patients.An experimental study was performed to clarify the therapeutic effects of bepridil, a multiple ionic current inhibitor that does not affect beta-adrenergic receptors, for premature beats occurring during enhanced sympathetic nerve activity. Cardio-sympathetic nerve activity was augmented via stellate-ganglion (SG) stimulation in a canine model (n = 8), and the arrhythmogenic potential and anti-arrhythmic effects of bepridil (2 and 4 mg/kg intravenously) were assessed. For safe use, vagal-stimulation-induced slow HR and programmed electrical stimulation were applied to evaluate possible pro-arrhythmic effects of the drug. Heart rate variability (HRV) indexes were used to estimate cardio-autonomic nerve activity.Either side of the SG-stimulation increased BP and HR. Premature beats were induced in 10/16 SG-stimulations and it was more frequent in left (8/8) rather than right stimulation (2/8). Following 2 mg/kg drug administration, premature beats were still inducible in 8/16 stimulations (7/8 in left and 1/8 in right), but burden of the premature beats decreased from 87.1 ± 46.8 to 62.1 ± 42.6 beats. After 4 mg/kg administration, premature beats were inducible in one SG-stimulation. Proarrhythmic effects were not observed in all experiments. Steady-state HRV indexes and percent increases in SG-stimulation-induced BP-elevation and HR-acceleration were similar among the 3 periods (before, 2 and 4 mg/kg of the drug).Bepridil may be an option for ventricular arrhythmias developed during enhanced cardio-sympathetic nerve activity with minimal effect on autonomic nerve responses.

    DOI： 10.1536/ihj.19-494

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  • Therapy-Resistant Ventricular Arrhythmias Developed More Often in Advanced Than in Therapeutic Mild Hypothermic Condition. Reviewed

    Saitoh O, Watanabe J, Oikawa A, Sugai A, Furushima H, Chinushi M

    International heart journal   60 ( 5 )   1161 - 1167   2019.9

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    Therapy-resistant ventricular arrhythmias can occur during accidental advanced hypothermic conditions. On the other hand, hypothermic therapy using mild cooling has been successfully accomplished with infrequent ventricular arrhythmia events.To further clarify the therapeutic-resistant arrhythmogenic substrate which develops in hypothermic conditions, an experimental study was performed using a perfusion wedge preparation model of porcine ventricle, and electrophysiological characteristics, inducibility of ventricular arrhythmias, and effects of therapeutic interventions were assessed at 3 target temperatures (37, 32 and 28°C).As the myocardial temperature decreased, myocardial contractions and the number of spontaneous beats deceased. Depolarization (QRS width, stimulus-QRS interval) and repolarization (QT interval, ERP) parameters progressively increased, and dispersion of the ventricular repolarization increased. At 28°C, VF tended to be inducible more frequently (1/11 at 37°C, 1/11 at 32°C, and 5/11 hearts at 28°C), and some VFs at 28°C required greater defibrillation energy to resume basic rhythm.An advanced but not a mild hypothermic condition had an enhanced arrhythmogenic potential in our model. In the advanced hypothermic condition, VF with relatively prolonged F-F intervals and a greater defibrillation energy were occasionally inducible based on the arrhythmogenic substrate characterized as slowed conduction and prolonged repolarization of the ventricle.

    DOI： 10.1536/ihj.18-711

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  • Enhanced arrhythmogenic potential induced by renal autonomic nerve stimulation: Role of renal artery catheter ablation Reviewed International journal

    Masaomi Chinushi, Osamu Saitoh, Ayari Sugai, Ayaka Oikawa, Junya Watanabe, Hiroshi Furushima

    Heart Rhythm   17 ( 1 )   133 - 141   2019.7

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier {BV}  

    BACKGROUND: Renal artery catheter ablation has been reported as a possible therapeutic option for drug-refractory ventricular arrhythmias (VAs) associated with structural heart diseases. OBJECTIVE: To further clarify its therapeutic background, we examined the relationship between electrical nerve stimulation (ENS)-induced blood pressure (BP) elevation and occurrence of VAs by using an acute canine model of renal artery ablation. METHODS: Using a decapolar electrode catheter, ENS was successively applied from the distal, mid, and proximal segments of the renal artery in 8 beagles. The same ENS was repeated after accomplishment of radiofrequency ablation at the ostial site of the renal artery by using an irrigation catheter. RESULTS: Before ablation, ENS increased BP from 140 ± 11/77 ± 11 to 167 ± 20/98 ± 16 mm Hg and heart rate from 100 ± 21 to 131±33 beats/min as well as induced VAs in 20 of the 45 ENS applications. Occurrence of VAs was associated with a greater magnitude of sympathetic nerve augmentation, and VAs were more frequently observed by ENS at the distal (67%) rather than mid/proximal segments of the renal artery (33%). Renal artery ablation was accomplished without any angiographic stenosis, and ENS-induced BP elevation, heart rate acceleration, and VAs occurrence were attenuated not only at the close segment (proximal) but also at the remote segments (mid/distal) of the renal artery. CONCLUSION: The renal autonomic nerves are considered as one of the therapeutic targets for suppression of frequent VAs because its activation has arrhythmogenic potential and induces premature ventricular beats.

    DOI： 10.1016/j.hrthm.2019.07.029

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  • Electrode Contact Force-Controlled Bipolar Radiofrequency Ablation: Different Effects on Lesion Size between Dual- and Single-Bath Preparations Reviewed

    Masaomi Chinushi, Osamu Saitoh, Junya Watanabe, Ayari Sugai, Katsuya Suzuki, Yukio Hosaka, Hiroshi Furushima

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   40 ( 3 )   223 - 231   2017.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/pace.12993

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  • Electrical stimulation-based evaluation for functional modification of renal autonomic nerve activities induced by catheter ablation Reviewed

    Masaomi Chinushi, Katsuya Suzuki, Osamu Saitoh, Hiroshi Furushima, Kenichi Iijima, Daisuke Izumi, Akinori Sato, Mika Sugai, Mitsuya Iwafuchi

    HEART RHYTHM   13 ( 8 )   1707 - 1715   2016.8

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    DOI： 10.1016/j.hrthm.2016.04.021

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  • Blood pressure and autonomic responses to electrical stimulation of the renal arterial nerves before and after ablation of the renal artery Reviewed

    Masaomi Chinushi, Daisuke Izumi, Kenichi Iijima, Katsuya Suzuki, Hiroshi Furushima, Osamu Saitoh, Yui Furuta, Yoshifusa Aizawa, Mitsuya Iwafuchi

    Hypertension   61 ( 2 )   450 - 456   2013.2

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    DOI： 10.1161/HYPERTENSIONAHA.111.00095

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  • The peak-to-end of the T wave in the limb ECG leads reflects total spatial rather than transmural dispersion of ventricular repolarization in an anthopleurin-A model of prolonged QT interval Reviewed

    Daisuke Izumi, Masaomi Chinushi, Kenichi Iijima, Hiroshi Furushima, Yukio Hosaka, Kanae Hasegawa, Yoshifusa Aizawa

    HEART RHYTHM   9 ( 5 )   796 - 803   2012.5

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    DOI： 10.1016/j.hrthm.2011.11.046

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  • Is the coexistence of sustained ST-segment elevation and abnormal Q waves a risk factor for electrical storm in implanted cardioverter defibrillator patients with structural heart diseases? Reviewed

    Hiroshi Furushima, Masaomi Chinushi, Kenichi Iijima, Kanae Hasegawa, Akinori Sato, Daisuke Izumi, Hiroshi Watanabe, Yoshifusa Aizawa

    EUROPACE   14 ( 5 )   675 - 681   2012.5

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    DOI： 10.1093/europace/eur386

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  • Triggers of ventricular tachyarrhythmias and therapeutic effects of nicorandil in canine models of LQT2 and LQT3 syndromes Reviewed

    M Chinushi, H Kasai, M Tagawa, T Washizuka, Y Hosaka, Y Chinushi, Y Aizawa

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   40 ( 3 )   555 - 562   2002.8

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    DOI： 10.1016/S0735-1097(02)01975-7

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  • Lesion characteristics created by bipolar radiofrequency ablation; right-vs. left-side of septum and epicardium vs. endocardium in the free wall. International journal

    Osamu Saitoh, Takumi Kasai, Ryosuke Inomata, Hiroshi Furushima, Masaomi Chinushi

    Indian pacing and electrophysiology journal   2026.3

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    BACKGROUND: Circumstances around ablation catheters placed in the ventricular cavity and pericardial space are not identical, and therefore bipolar (BIP) ablation targeting the interventricular septum (IVS) or left ventricular free wall (LVFW) may induce lesions with different characteristics on either side of the wall. METHODS: Porcine hearts prepared for IVS or LVFW were placed between two inner containers which were set in an outer experimental container. For IVS ablation, each inner container was filled with Tyrode's solution circulated by a pump to mimic the right- and left-ventricular cavities. For LVFW ablation, a plastic board was inserted into one of the inner containers to mimic the pericardial space, thereby minimizing the circulating solution. Thereafter, BIP ablation (30W, 120-s) was attempted 30 applications each in IVS and LVFW. RESULTS: All 60 applications were successfully accomplished without steam-pop. Total impedance decline (TID) and %-TID were larger in LVFW than IVS ablation (-19.4 ± 5.3 vs. -15.8 ± 4.6 Ω, and -16.2 ± 4.0 vs. -13.2 ± 3.6%), and total lesion depth was deeper in LVFW than in IVS (14.4 ± 2.6 vs. 12.7 ± 3.3 mm) due to deeper lesions in the epicardial wall. Surface lesions were also larger in epicardial than in endocardial wall in LVFW ablation, whereas there were no differences between right- and left-side septal wall. Transmural lesion was created in 13/30 in LVFW and 9/30 in IVS ablation. CONCLUSIONS: As compared to IVS, BIP ablation targeting LVFW demonstrated larger TID and induced deeper lesions in the epicardial wall in this study, probably due to less current leakage into the small space.

    DOI： 10.1016/j.ipej.2026.03.014

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  • Differential Responses of J waves to Heart Rate Changes in Idiopathic Ventricular Fibrillation and General Population in Japan. International journal

    Yoshifusa Aizawa, Masafumi Nakayama, Takanori Aizawa, Kanae Hasegawa, Satoshi Nagase, Naohiko Takahashi, Minoru Horie, Masaomi Chinushi, Yoshiyasu Aizawa, Michel Haïssaguerre

    Heart rhythm   2026.3

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    Previous case studies have reported bradycardia-dependent augmentation of J waves in patients with idiopathic ventricular fibrillation (VF). However, the response patterns of J waves to changing heart rates have rarely been evaluated in the general population. In this review, the response patterns of J waves to changing RR intervals were studied in the general population during premature beats or pacing and compared with those of J waves in idiopathic VFs and the mechanism and clinical importance of J waves are discussed. J waves associated with idiopathic VFs showed bradycardia-dependent augmentation and tachycardia-dependent attenuation, whereas J waves unrelated to idiopathic VFs exhibited tachycardia-dependent augmentation and less obvious bradycardia-dependent attenuation. These different response patterns suggest the presence of different mechanisms-repolarization-dependent and depolarization-dependent mechanisms-and can be used for risk stratification and selection of therapeutic options.

    DOI： 10.1016/j.hrthm.2026.03.1892

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  • Relation between resting amygdala activity and cardiovascular events in patients with cardiac sarcoidosis

    Sou Otsuki, Masahiro Hatakeyama, Atsushi Michael Kimura, Kosei Nakamura, Mikhail Ratanov, Rie Akagawa, Hironori Furuse, Naomasa Suzuki, Yasuhiro Ikami, Yuki Hasegawa, Masaomi Chinushi, Hitoshi Shimada, Takayuki Inomata

    European Journal of Nuclear Medicine and Molecular Imaging   2025.4

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Purpose

    Previous studies indicate amygdala activity (AmygA) measured by FDG-positron emission tomography (PET) predicts the risk of subsequent cardiovascular events. However, AmygA measurement use for predicting the prognosis of patients with cardiac sarcoidosis (CS) is unknown. We aimed to investigate the association between AmygA and cardiovascular events in patients with CS.

    Methods

    Consecutive 40 patients with CS who underwent FDG-PET were identified retrospectively. Cardiovascular events included ventricular tachyarrhythmias and heart failure hospitalizations. We examined the association between AmygA and cardiovascular events and investigated the timing of FDG-PET influence on AmygA measurements.

    Results

    During a follow-up of 4.5 (2.5–7.7) years, 14 (35%) patients experienced cardiovascular events. Left-AmygA was a stronger cardiovascular event predictor than the Right-AmygA, and incidences were significantly higher in the high left-AmygA group than low group (log-rank P = 0.018). Multivariable analysis revealed left-AmygA augmentation (hazard ratio [HR]: 1.76 per 0.1 increase, 95% confidence interval [CI]: 1.12–2.87, P = 0.016) was the only independent predictor of cardiovascular event. Among the 40 patients, 32 underwent multiple PET-scans. No significant difference was found between the AmygA value on the first PET-scan and the mean on multiple PET scans, and the correlation coefficient was 0.93 (P < 0.001). Multivariate analyses revealed the mean left-AmygA value was the only independent predictor of cardiovascular event (P = 0.011).

    Conclusions

    High left-AmygA was associated with the higher rates of cardiovascular events in patients with CS. AmygA would be a prognostic biomarker regardless of the PET-scan timing.

    DOI： 10.1007/s00259-025-07266-3

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    Other Link： https://link.springer.com/article/10.1007/s00259-025-07266-3/fulltext.html

  • CORRIGENDUM: JCS/JHRS 2022 Guideline on Diagnosis and Risk Assessment of Arrhythmia.

    Bonpei Takase, Takanori Ikeda, Wataru Shimizu, Haruhiko Abe, Takeshi Aiba, Masaomi Chinushi, Shinji Koba, Kengo Kusano, Shinichi Niwano, Naohiko Takahashi, Seiji Takatsuki, Kaoru Tanno, Eiichi Watanabe, Koichiro Yoshioka, Mari Amino, Tadashi Fujino, Yu-Ki Iwasaki, Ritsuko Kohno, Toshio Kinoshita, Yasuo Kurita, Nobuyuki Masaki, Hiroshige Murata, Tetsuji Shinohara, Hirotaka Yada, Kenji Yodogawa, Takeshi Kimura, Takashi Kurita, Akihiko Nogami, Naokata Sumitomo

    Circulation journal : official journal of the Japanese Circulation Society   90 ( 1 )   147 - 147   2025

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    DOI： 10.1253/circj.CJ-66-0246

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  • Submyocardial Pacing Threshold Distribution During Cold Saline Application; Exploring Reversible Arrhythmia Inhibition. International journal

    Osamu Saitoh, Takumi Kasai, Ayaka Oikawa, Yuki Hasegawa, Sou Otsuki, Minoru Tagawa, Hiroshi Furushima, Takayuki Inomata, Masaomi Chinushi

    Pacing and clinical electrophysiology : PACE   2024.11

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    INTRODUCTION: Cold saline application through an irrigation catheter may induce reversible inhibition of submyocardial excitation, which may be used to identify in advance an ideal site for radiofrequency (RF) energy delivery around delicate areas. METHODS: An open irrigation catheter was positioned vertically or parallel with 10-g contact on coronary perfusing porcine hearts and the contacted myocardium was cooled by cold saline at 4°C (20 mL/min). A temperature electrode was inserted 2 mm below the myocardial surface (intra-myocardial temperature at approximately 2 mm below the surface [Temp-BS]). Pacing threshold inside the ventricular wall was measured using an eight-pole electrode plunge needle inserted 5-8 mm close to the ablation catheter, and percent increase of the pacing threshold by the cold saline application (%increase-PT) was calculated. RESULTS: During cooling, pacing at 10 V from the myocardial surface interrupted constant capture in 7/10 experiments in vertical and in 9/10 experiments in parallel ablation catheter contact. Minimum Temp-BS was not different in both catheter contact positions (25.9 ± 4.0°C in vertical vs. 25.4 ± 2.6°C in parallel). Large % increase-PT on the surface myocardium decreased as the myocardial depth became deeper, and > 150% increase was at a depth approximately 2-3 mm from the surface and > 120% increase around 6-7 mm from the surface. After cessation of cold saline application, the increased %increase-PT recovered to the pre-cooling values. CONCLUSIONS: Cold saline application through an irrigation catheter reversibly inhibited submyocardial excitation. This simple method may have the potential to pre-determine the ideal ablation site in sensitive areas of the heart, although further studies and technological adjustments are required before clinical use.

    DOI： 10.1111/pace.15104

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  • Lesion characteristics of long application time ablation using unipolar half-normal saline irrigation and bipolar normal saline irrigation. International journal

    Takumi Kasai, Osamu Saitoh, Ayaka Oikawa, Naomasa Suzuki, Yasuhiro Ikami, Yuki Hasegawa, Sou Otsuki, Takayuki Inomata, Hiroshi Furushima, Masaomi Chinushi

    Indian pacing and electrophysiology journal   2024.11

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    INTRODUCTION: Unipolar radiofrequency (RF) ablation using half-normal saline irrigation (UNIP-HNS) and bipolar RF ablation using normal saline irrigation (BIP-NS) are effective to treat arrhythmias from inside thick myocardium. However, differences between these two ablations when using a long application time had not fully been studied. METHODS: UNIP-HNS, BIP-NS and unipolar RF ablation using normal saline irrigation (UNIP-NS) were applied for 120 seconds (30 W and 20-g contact) to porcine endocardial wall (≧15.0 mm thickness). RESULTS: All ablations (30 applications each in UNIP-HNS and BIP-NS, and 20 applications in UNIP-NS) were successfully accomplished without steam-pop. Total impedance decline was largest in BIP-NS followed by UNIP-HNS and UNIP-NS. UNIP-HNS created larger surface lesions and greater maximum lesion width under the surface than those by UNIP-NS and BIP-NS. Endocardial lesion depth in UNIP-HNS and BIP-NS were deeper than that in UNIP-NS, but with no difference between UNIP-HNS and BIP-NS, when selecting non-transmural lesions. Similar results were obtained when all lesions (non-transmural and transmural) were included and endocardial lesion depth of the transmural lesions (13/30 applications of BIP-NS) was estimated as 50% of the myocardial thickness. Lesion length in the transverse myocardial wall (endocardial plus epicardial lesions) was greatest in BIP-NS. CONCLUSIONS: Longer application time ablation (30 W) targeting the thick myocardium was performable in UNIP-HNS and BIP-NS. Since a transmural lesion and/or a deeper lesion into the myocardial wall are created, BIP-NS is preferable if two ablation catheters can be positioned on either side of the target.

    DOI： 10.1016/j.ipej.2024.11.003

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  • Association between early repolarization and vagally mediated atrial fibrillation

    Yuki Hasegawa, Hirotaka Sugiura, Akiko Sanada, Asako Tomii, Shinsuke Okada, Kotaro Higuchi, Masaomi Chinushi, Takayuki Inomata

    Heart Rhythm   21 ( 11 )   2353 - 2354   2024.11

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.hrthm.2024.05.033

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  • JCS/JHRS 2022 Guideline on Diagnosis and Risk Assessment of Arrhythmia.

    Bonpei Takase, Takanori Ikeda, Wataru Shimizu, Haruhiko Abe, Takeshi Aiba, Masaomi Chinushi, Shinji Koba, Kengo Kusano, Shinichi Niwano, Naohiko Takahashi, Seiji Takatsuki, Kaoru Tanno, Eiichi Watanabe, Koichiro Yoshioka, Mari Amino, Tadashi Fujino, Yu-Ki Iwasaki, Ritsuko Kohno, Toshio Kinoshita, Yasuo Kurita, Nobuyuki Masaki, Hiroshige Murata, Tetsuji Shinohara, Hirotaka Yada, Kenji Yodogawa, Takeshi Kimura, Takashi Kurita, Akihiko Nogami, Naokata Sumitomo

    Journal of arrhythmia   40 ( 4 )   655 - 752   2024.8

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    DOI： 10.1002/joa3.13052

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  • Differences in coagulation responses to vascular injury between uninterrupted dabigatran and apixaban: A clinical prospective randomized study. International journal

    Yasuhiro Ikami, Daisuke Izumi, Shinya Fujiki, Hirotaka Sugiura, Sou Otsuki, Naomasa Suzuki, Yuta Sakaguchi, Takahiro Hakamata, Yuki Hasegawa, Nobue Yagihara, Kenichi Iijima, Takahiro Tanaka, Masahiro Ishizawa, Masaomi Chinushi, Tohru Minamino, Takayuki Inomata

    Heart rhythm   2024.7

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    BACKGROUND: The coagulation response during vascular injury with uninterrupted administration of direct oral anticoagulants has not been elucidated. OBJECTIVE: Our aim was to evaluate differences in coagulation responses after vascular injury between uninterrupted direct thrombin inhibitor and direct factor Xa inhibitor recipients. METHODS: Patients scheduled for catheter ablation for atrial fibrillation were randomly assigned to receive dabigatran or apixaban in this prospective, randomized, comparative, parallel-group study. Venous blood was collected 3 times: 180 minutes after taking the anticoagulant on the day before the procedure, before vascular punctures of the ablation procedure, and 10-15 minutes after the start of vascular punctures. RESULTS: Forty-two patients were enrolled. The prothrombin fragment 1+2 level, the primary end point, was much larger after vascular puncture in the uninterrupted dabigatran recipients (median, 83 pmol/L; interquartile range, 56-133 pmol/L) than in the uninterrupted apixaban recipients (median, 1 pmol/L; interquartile range, -3 to 19 pmol/L; P < .001). Antithrombin levels decreased after vascular puncture in dabigatran recipients, and both protein C and antithrombin levels decreased after vascular puncture in apixaban recipients. CONCLUSION: Unlike uninterrupted apixaban, uninterrupted dabigatran does not inhibit thrombin generation in response to vascular injury.

    DOI： 10.1016/j.hrthm.2024.07.017

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  • Correlation between Time Course of Ventricular Tachyarrhythmias and Improvement of LVEF after Induction of Steroid Therapy in Cardiac Sarcoidosis(タイトル和訳中)

    鈴木 尚真, 大槻 総, 和田 理澄, 赤川 理恵, 井神 康宏, 長谷川 祐紀, 池主 雅臣, 猪又 孝元

    日本循環器学会学術集会抄録集   88回   PJ085 - 4   2024.3

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  • Clinical Impact of Intraoperative Target Branch Changes in Left-Ventricular Lead Placement for Cardiac Resynchronization Therapy(タイトル和訳中)

    井神 康宏, 赤川 理恵, 鈴木 尚真, 長谷川 祐紀, 大槻 総, 池主 雅臣, 猪又 孝元

    日本循環器学会学術集会抄録集   88回   PJ052 - 3   2024.3

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  • Myocardium with Unstable Excitability under Durable Lesion: Difference in Conductive Heating Effect between Short and Moderate RF Application Time(タイトル和訳中)

    齋藤 修, 笠井 琢充, 及川 綾花, 古嶋 博司, 井神 康宏, 鈴木 尚真, 長谷川 祐紀, 大槻 総, 池主 雅臣

    日本循環器学会学術集会抄録集   88回   PJ045 - 3   2024.3

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  • Symmetrical recovery time course between impedance and intramyocardial temperature after bipolar radiofrequency ablation; Role of impedance monitoring to estimate temperature rise. International journal

    Takumi Kasai, Osamu Saitoh, Kyogo Fuse, Ayaka Oikawa, Hiroshi Furushima, Masaomi Chinushi

    Indian pacing and electrophysiology journal   2023.12

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    INTRODUCTION: During radiofrequency (RF) ablation, impedance monitoring has been used to avoid steam-pop caused by excessive intramyocardial temperature (IMT) rise. However, it is uncertain why the impedance decline is related to steam-pop and whether the impedance decline is correlated to IMT. METHODS: Twenty-one bipolar ablations (40 W, 30-g contact, 120 s) were attempted for seven perfused porcine myocardium. Immediately after ablation, a temperature electrode was inserted into the mid-myocardial portion, and the recovery process of impedance and its correlation to IMT were assessed. RESULTS: Transmural lesion was created in all 21 applications but steam-pop occurred in 5/21 applications with large impedance decline. In the 16 applications without steam-pop, impedance and IMT soon after ablation were 97.2 ± 4.0 Ω and 66.1 ± 4.8 °C, respectively. Reasonably high linear correlation was demonstrated between the maximum IMT after ablation and impedance differences before and after ablation. Recovery processes of the decreased impedance and the elevated IMT fit well to each equation of the single exponential decay function and showed symmetric shapes with no statistical difference of time constant (100.1 ± 34.5 s in impedance vs. 108.7 ± 27.3 s in IMT) and half-time of recovery (144.5 ± 49.8 s in impedance vs. 156.9 ± 39.4 s in IMT). Recovered impedance after ablation (104.8 ± 3.9 Ω) was 5.1 ± 2.0 Ω smaller than that before ablation (109.9 ± 2.7 Ω), suggesting several factors other than IMT rise participate in impedance decline in RF ablation. CONCLUSIONS: Recovery of impedance and IMT after ablation well correlated, which supports the usefulness of impedance monitoring for safe RF ablation.

    DOI： 10.1016/j.ipej.2023.12.001

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  • Distribution of excitation recoverable myocardium after radiofrequency ablation and its relation to energy application time and irrigation. International journal

    Osamu Saitoh, Takumi Kasai, Kyogo Fuse, Masaomi Chinushi

    Journal of cardiovascular electrophysiology   34 ( 4 )   928 - 941   2023.4

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    INTRODUCTION: Radiofrequency (RF) catheter ablation induces excitation recoverable myocardium around durable core lesions, and its distribution may be different depending on energy delivery methods. METHODS AND RESULTS: In coronary perfusing porcine hearts, pacing threshold through the ventricle was measured using eight-pole (1-mm distance) needle electrodes vertically inserted into myocardium before, within 3 min after and 40 min after 40 W ablation with 10-g catheter contact (Group 1: irrigation catheter for 15 s, Group 2: irrigation catheter for 40 s, Group 3: nonirrigation catheter for 15 s, Group 4: nonirrigation catheter for 40 s). Ablation was accomplished in all 12 ablations in Groups 1-3 whereas in 8/12 ablations in Group 4 because of high-temperature rise. Within 3 min after ablation, 10.0 V pacing uncaptured electrodes were distributed from the surface to inside the myocardium, and its depth was deeper in 40 s than in 15 s ablation. 40 min after ablation, excitation recovery at one or more electrodes below the durable lesion was observed in all Groups. Excitation recovery electrodes were also observed on the surface in Group 1 but not the other Groups. Accordingly, the number of excitation-recovered electrodes were larger in Group 1 than the other Groups. CONCLUSIONS: Regardless of the ablation methods, excitation recoverable myocardium was present around 1.0 mm below the durable lesions. Lesions created by short application time using an irrigation catheter may have included large excitation recoverable myocardium soon after ablation because of the presence of reversible myocardium on well-irrigated myocardial surfaces.

    DOI： 10.1111/jce.15873

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  • 心房細動のTriggerおよびDriverと考えられる上大静脈(SVC)の細動様電気活動の焼灼部位決定にCARTOでのCFAE mappingが有用であった1例

    坂口 裕太, 和泉 大輔, 鈴木 尚真, 袴田 崇裕, 井神 康宏, 大槻 総, 飯嶋 賢一, 八木原 伸江, 池主 雅臣, 猪又 孝元

    心臓   54 ( Suppl.1 )   20 - 20   2022.11

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  • Clinical impact of ECG changes on oversensing of subcutaneous implantable cardioverter-defibrillators. International journal

    Takahiro Hakamata, Sou Otsuki, Daisuke Izumi, Yuta Sakaguchi, Naomasa Suzuki, Yasuhiro Ikami, Yuki Hasegawa, Nobue Yagihara, Kenichi Iijima, Masaomi Chinushi, Koichi Fuse, Takayuki Inomata

    Heart rhythm   19 ( 10 )   1704 - 1711   2022.10

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    BACKGROUND: Inappropriate shocks delivered by subcutaneous implantable cardioverter-defibrillators (S-ICDs) are most frequently caused by cardiac oversensing. However, the predictors for oversensing of S-ICD remain unclear. OBJECTIVE: We aimed to investigate the predictors for oversensing of S-ICD, especially clinical impact of an electrocardiographic (ECG) change. METHODS: We retrospectively enrolled 99 consecutive patients who underwent S-ICD implantation between 2013 and 2021. Oversensing events were defined as inappropriate charge of the capacitors induced by cardiac or noncardiac signals other than tachycardia. RESULTS: During a median follow-up period of 34 months (interquartile range 20-50 months), 11 of 99 patients (11%) experienced 34 oversensing events and 4 patients (4%) received inappropriate shocks during their events. Six patients exhibited ECG changes (bundle branch block, 3; ventricular pacing, 1; inverted T wave, 1; poor R-wave progression, 1) during the follow-up period. Oversensing events were observed in 4 of 6 patients with ECG change (67%), and 3 patients underwent S-ICD removal because of inevitable shock. Contrastingly, of the remaining patients without ECG change, all 7 patients who experienced oversensing events could continue using S-ICD with the reprogramming sensing vector and/or restriction of excessive exercise. Logistic regression analysis showed that lower voltage of Sokolow-Lyon ECG (V1S + V5R) was the predictor of oversensing in patients without ECG change. When the cutoff value was 2.1 mV, the sensitivity, specificity, positive predictive value, and negative predictive value were 85.7%, 62.7%, 15.7%, and 98.1%, respectively. CONCLUSION: Unavoidable oversensing resulting in S-ICD removal is caused by ECG change. Oversensing in patients without ECG change can be managed.

    DOI： 10.1016/j.hrthm.2022.05.037

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  • Impedance‐decline‐guide power control long application time bipolar radiofrequency catheter ablation Reviewed

    Osamu Saitoh, Takumi Kasai, Kyogo Fuse, Ayaka Oikawa, Hiroshi Furushima, Masaomi Chinushi

    Journal of Cardiovascular Electrophysiology   2022.9

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    DOI： 10.1111/jce.15684

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  • Clinical impact of nocturnal ventricular tachyarrythmias in electrical storm. International journal

    Naomasa Suzuki, Sou Otsuki, Daisuke Izumi, Rie Akagawa, Yuta Sakaguchi, Takahiro Hakamata, Yasuhiro Ikami, Yuki Hasegawa, Nobue Yagihara, Kenichi Iijima, Masaomi Chinushi, Takayuki Inomata

    Pacing and clinical electrophysiology : PACE   45 ( 11 )   1330 - 1337   2022.9

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    BACKGROUND: The incidence of electrical storm (ES) is significantly higher during the daytime. However, the association between nocturnal ventricular tachyarrythmias during ES and prognosis remains unclear. Therefore, this study aimed to investigate the clinical characteristics and outcomes of ES with midnight ventricular tachyarrythmias. METHODS: We included 48 consecutive patients who had an implantable cardioverter-defibrillator or cardiac resynchronization therapy defibrillator implanted between 2010 and 2020 and those who had experienced the onset of an out-of-hospital ES episode. According to the midnight (0:00 a.m.-6:00 a.m.) occurrence of ventricular arrythmia events consisting of ventricular tachycardia (VT) and ventricular fibrillation (VF), we divided them into two groups (with-midnight group: n = 27, without-midnight group: n = 21). The clinical characteristics and outcomes of the two groups were compared. RESULTS: The patients in the with-midnight group were mostly males, had longer QRS duration, and longer corrected QT-interval than those in the without-midnight group (p < .05). The incidence of all-cause death, especially heart failure death, was higher in the with-midnight group than in the without-midnight group (p < .01). Multivariate analysis showed that the presence of midnight VT/VF during ES was the only independent risk factors for heart failure death (HR = 18.9, 95%CI = 1.98-181, p = .011). CONCLUSIONS: The presence of midnight VT/VF during ES might be associated with the poor prognosis. The loss of a sympathetic circadian pattern of VT/VF distribution during ES might suggest advanced stages of the cardiac disease.

    DOI： 10.1111/pace.14592

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  • Excitation Recovery on the Surface Myocardium After Shorter but Not Nominal Time Radiofrequency Application Using an Open Irrigation Catheter

    Masaomi Chinushi, Osamu Saitoh

    Circulation. Arrhythmia and electrophysiology   15 ( 1 )   e010392   2022.1

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    DOI： 10.1161/CIRCEP.121.010392

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  • The Risk of Ventricular Tachyarrhythmias in Patients with Antimitochondrial Antibodies-Related Noncardiac Diseases.

    Yasuhiro Ikami, Daisuke Izumi, Yuki Hasegawa, Naomasa Suzuki, Yuta Sakaguchi, Takahiro Hakamata, Sou Otsuki, Nobue Yagihara, Kenichi Iijima, Takeshi Kashimura, Masaomi Chinushi, Tohru Minamino, Takayuki Inomata

    International heart journal   63 ( 3 )   476 - 485   2022

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    Antimitochondrial antibodies (AMA) are serum autoantibodies specific to primary biliary cholangitis and are linked to myopathy and myocardial damage; however, the presence of AMA as a risk factor for ventricular tachyarrhythmias (VTs) has remained unknown. This study aimed to elucidate whether the presence of AMA-related noncardiac diseases indicates VTs risk.This cohort study enrolled 1,613 patients (883 females) who underwent AMA testing to assess noncardiac diseases. The incidence of VTs and supraventricular tachyarrhythmias (SVTs) from a year before the AMA testing to the last visit of the follow-up were retrospectively investigated as primary and secondary objectives. Using propensity score matching, we extracted AMA-negative patients whose covariates were matched to those of 152 AMA-positive patients. In this propensity score-matched cohort, the incidence of VTs and SVTs in the AMA-positive patients were compared with that in AMA-negative patients.The AMA-positive patients had higher estimated cumulative incidence (log-rank, P = 0.013) and prevalence (5.9% versus 0.7%, P = 0.020) of VTs than the AMA-negative patients. The presence of AMA was an independent risk factor for VTs (hazard ratio, 4.02; 95% CI, 1.44-20.01; P = 0.005). Meanwhile, AMA were associated with atrial flutter and atrial tachycardia development. In AMA-positive patients, VTs were associated with male sex, underlying myopathy, high creatine kinase levels, presence of chronic heart failure or ischemic heart disease, left ventricular dysfunction, presence of SVTs, and the electrocardiographic parameters indicating atrial disorders.The presence of AMA-related noncardiac diseases is an independent risk factor for VTs.

    DOI： 10.1536/ihj.22-075

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  • 脂肪沈着領域にリエントリー回路が同定された陳旧性心筋梗塞の1例

    大槻 総, 和泉 大輔, 井神 康宏, 長谷川 祐紀, 八木原 伸江, 飯嶋 賢一, 池主 雅臣, 南野 徹

    心臓   53 ( Suppl.1 )   25 - 25   2021.11

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  • Efficacy of antitachycardia pacing alert by remote monitoring of implantable cardioverter-defibrillators for out-of-hospital electrical storm. International journal

    Sou Otsuki, Daisuke Izumi, Yuta Sakaguchi, Naomasa Suzuki, Takahiro Hakamata, Yasuhiro Ikami, Yuki Hasegawa, Nobue Yagihara, Kenichi Iijima, Masaomi Chinushi, Tohru Minamino, Inomata Takayuki

    Pacing and clinical electrophysiology : PACE   44 ( 10 )   1675 - 1682   2021.10

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    BACKGROUND: Remote monitoring (RM) has been shown to reduce all-cause mortality in patients with implantable cardioverter-defibrillators or cardiac resynchronization therapy defibrillators (ICD/CRT-D). Not all devices transmit an alert for antitachycardia pacing (ATP) therapy, and it is unknown whether differences of RM alert affect the outcomes of electrical storm (ES). METHODS: We enrolled 42 patients with ICD/CRT-D whose out-of-hospital ES were detected by RM between 2013 and 2020. We divided their 54 episodes into two groups (ATP-alert-on; 22, ATP-alert-off; 32), and clinical outcomes were compared between the two groups. RESULTS: In 35 of 54 episodes of ES, ventricular tachycardia (VT) could be terminated within 24 h of ES onset just by ATP (ATP-alert-on: 14, ATP-alert-off: 21); however, many patients subsequently received shock delivery for VT. Among the 35 episodes, only in ATP-alert-on group, seven patients were prompted to visit our hospital without ICD shock through confirmation of ES by ATP-alert. Episodes that led to shock delivery 24 h or longer after the ES onset were significantly less common in the ATP-alert-on group (ATP-alert-on: 1/14, ATP-alert-off: 9/21, p = .03). Although there were no significant differences in the number of shock deliveries between episodes in the two groups, the number of ATP deliveries were significantly fewer in the ATP-alert-on group (12[7-26] vs. 29[16-53] in ATP-alert-off group, p = .03). Multivariate logistic regression analyses showed that the only ATP-alert significantly reduced ATP deliveries (HR = 0.14, 95%CI = 0.04-0.57, p = .003). CONCLUSION: Remote monitoring with an ATP-alert function during electrical storm may reduce appropriate ICD therapy through prompting early review.

    DOI： 10.1111/pace.14334

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  • Anti‐tachycardia pacing for non‐fast and fast ventricular tachycardias in individual Japanese patients: From Nippon‐storm study

    Masaomi Chinushi, Osamu Saitoh, Hiroshi Furushima, Yoshifusa Aizawa, Takashi Noda, Takashi Nitta, Tohru Ohe, Takashi Kurita

    Journal of Arrhythmia   37 ( 4 )   1038 - 1045   2021.8

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    BACKGROUND: Anti-tachycardia pacing (ATP) delivered from an implantable device is a useful tool to terminate ventricular tachycardia (VT). But its real-world efficacy for those patients having multiple VTs with varying VT rates has not been fully studied. METHODS: Using the Nippon-storm study database, efficacy of patient-by-patient basis ATP programing for Japanese patients having both non-fast (120-187 bpm) and fast VT (≥188 bpm) was assessed. According to the useful criteria of ≥50% success termination by ATP, patients were divided into three subgroups; success ≥50% for both non-fast and fast VT (both useful), ≥50% only for non-fast VT (non-fast VT useful), or ≥50% for neither non-fast nor fast VT (neither useful). RESULTS: During a median follow-up of 28 months, ATP terminated 184 of the 203 non-fast VT episodes (91%) and 86 of the 113 fast VT episodes (76%) in all 41 patients. In the patient-by-patient analysis, efficacy of ATP was not different between non-fast and fast VT in most of the patients (36/41 = 88%); 32 patients were in the both useful and four other patients in the neither useful. Neither ischemic nor non-ischemic structural heart disease was associated with the ATP efficacy, whereas LVEF more than 37.0% and non-prescribed amiodarone were characteristics of the patients classified into the both useful. CONCLUSIONS: ATP well terminated both non-fast and fast VT occurring in individual Japanese patients with various structural heart diseases in the real-world device treatment and this finding further supports ATP programing for all device tachycardia detection zones in most patients with multiple VTs.

    DOI： 10.1002/joa3.12572

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  • JCS/JHRS 2019 guideline on non-pharmacotherapy of cardiac arrhythmias.

    Akihiko Nogami, Takashi Kurita, Haruhiko Abe, Kenji Ando, Toshiyuki Ishikawa, Katsuhiko Imai, Akihiko Usui, Kaoru Okishige, Kengo Kusano, Koichiro Kumagai, Masahiko Goya, Yoshinori Kobayashi, Akihiko Shimizu, Wataru Shimizu, Morio Shoda, Naokata Sumitomo, Yoshihiro Seo, Atsushi Takahashi, Hiroshi Tada, Shigeto Naito, Yuji Nakazato, Takashi Nishimura, Takashi Nitta, Shinichi Niwano, Nobuhisa Hagiwara, Yuji Murakawa, Teiichi Yamane, Takeshi Aiba, Koichi Inoue, Yuki Iwasaki, Yasuya Inden, Kikuya Uno, Michio Ogano, Masaomi Kimura, Shun-Ichiro Sakamoto, Shingo Sasaki, Kazuhiro Satomi, Tsuyoshi Shiga, Tsugutoshi Suzuki, Yukio Sekiguchi, Kyoko Soejima, Masahiko Takagi, Masaomi Chinushi, Nobuhiro Nishi, Takashi Noda, Hitoshi Hachiya, Masataka Mitsuno, Takeshi Mitsuhashi, Yasushi Miyauchi, Aya Miyazaki, Tomoshige Morimoto, Hiro Yamasaki, Yoshifusa Aizawa, Tohru Ohe, Takeshi Kimura, Kazuo Tanemoto, Hiroyuki Tsutsui, Hideo Mitamura

    Journal of arrhythmia   37 ( 4 )   709 - 870   2021.8

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    DOI： 10.1002/joa3.12491

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  • Progressive increase in activation delay during premature stimulation is related to ventricular fibrillation in Brugada syndrome International journal

    Yuki Hasegawa, Daisuke Izumi, Yasuhiro Ikami, Sou Otsuki, Nobue Yagihara, Kenichi Iijima, Masaomi Chinushi, Tohru Minamino

    Journal of Cardiovascular Electrophysiology   32 ( 7 )   1939 - 1946   2021.7

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    INTRODUCTION: The local conduction delay has been deemed to play an important role in the perpetuation of ventricular fibrillation (VF) in Brugada syndrome (BrS). We evaluated the relationship between the activation delay during programmed stimulation and cardiac events in BrS patients. METHODS: This study included 47 consecutive BrS patients who underwent an electrophysiological study and received implantable cardiac defibrillator therapy. We divided the patients into two groups based on whether they had developed VF (11 patients) or not (36 patients) during the follow-up period of 89 ± 53 months. The activation delay was assessed using the interval between the stimulus and the QRS onset during programmed stimulation. The mean increase in delay (MID) was used to characterize the conduction curves. RESULTS: The MID at the right ventricular outflow tract (RVOT) was significantly greater in patients with VF (4.5 ± 1.2 ms) than in those without VF (2.2 ± 0.9 ms) (p < .001). A receiver operating characteristics curve analysis indicated that the optimal cut-off point for discriminating VF occurrence was 3.3 with 88.9% sensitivity and 91.3% specificity. Furthermore, patients with an MID at the RVOT ≥ 3.3 ms showed significantly higher rates of VF recurrence than those with an MID at the RVOT < 3.3 ms (p < .001). The clinical characteristics, including the signal-averaged electrocardiogram measurement and VF inducibility were similar between the two groups. CONCLUSION: A prolonged MID at the RVOT was associated with VF and maybe an additional electrophysiological risk factor for VF in BrS patients.

    DOI： 10.1111/jce.15065

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  • Novel electrocardiographic criteria for short QT syndrome in children and adolescents. International journal

    Hiroshi Suzuki, Minoru Horie, Junichi Ozawa, Naokata Sumitomo, Seiko Ohno, Kenji Hoshino, Eiji Ehara, Kazuhiro Takahashi, Yoshichika Maeda, Masao Yoshinaga, Shigeru Tateno, Junichi Takagi, Shozaburo Doi, Satoshi Hoshina, Isamu Sato, Taisuke Ishikawa, Naomasa Makita, Masaomi Chinushi, Kohei Akazawa, Masami Nagashima

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology   23 ( 12 )   2029 - 2038   2021.6

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    AIMS: Although shortening of the corrected QT interval (QTc) is a key finding in the diagnosis of short QT syndrome (SQTS), there may be overlap of the QTc between SQTS patients and normal subjects in childhood and adolescence. We aimed to investigate electrocardiographic findings for differentiation of SQTS patients. METHODS AND RESULTS: The SQTS group comprised 34 SQTS patients <20 years old, including 9 from our institutions and 25 from previous reports. The control group comprised 61 apparently healthy subjects with an QTc of <360 ms who were selected from 13 314 participants in a school-based screening programme. We compared electrocardiographic findings, including QT and Jpoint-Tpeak intervals (QT and J-Tpeak, respectively), those corrected by using the Bazett's and Fridericia's formulae (cB and cF, respectively) and early repolarization (ER) between the groups. QT, QTc by using Bazett's formula (QTcB), QTc by using Fridericia's formula (QTcF), J-Tpeak, J-Tpeak cB, and J-Tpeak cF were significantly shorter in the SQTS group than in the control group. On receiver operating characteristic curve analysis, the area under the curve (AUC) was largest for QTcB (0.888) among QT, QTcB, and QTcF, with a cut-off value of 316 ms (sensitivity: 79.4% and specificity: 96.7%). The AUC was largest for J-Tpeak cB (0.848) among J-Tpeak, J-Tpeak cB, and J-Tpeak cF, with a cut-off value of 181 ms (sensitivity: 80.8% and specificity: 91.8%). Early repolarization was found more frequently in the SQTS group than in the control group (67% vs. 23%, P = 0.001). CONCLUSION: A QTcB <316 ms, J-Tpeak cB < 181 ms, and the presence of ER may indicate SQTS patients in childhood and adolescence.

    DOI： 10.1093/europace/euab097

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  • JCS/JHRS 2019 Guideline on Non-Pharmacotherapy of Cardiac Arrhythmias.

    Akihiko Nogami, Takashi Kurita, Haruhiko Abe, Kenji Ando, Toshiyuki Ishikawa, Katsuhiko Imai, Akihiko Usui, Kaoru Okishige, Kengo Kusano, Koichiro Kumagai, Masahiko Goya, Yoshinori Kobayashi, Akihiko Shimizu, Wataru Shimizu, Morio Shoda, Naokata Sumitomo, Yoshihiro Seo, Atsushi Takahashi, Hiroshi Tada, Shigeto Naito, Yuji Nakazato, Takashi Nishimura, Takashi Nitta, Shinichi Niwano, Nobuhisa Hagiwara, Yuji Murakawa, Teiichi Yamane, Takeshi Aiba, Koichi Inoue, Yuki Iwasaki, Yasuya Inden, Kikuya Uno, Michio Ogano, Masaomi Kimura, Shun-Ichiro Sakamoto, Shingo Sasaki, Kazuhiro Satomi, Tsuyoshi Shiga, Tsugutoshi Suzuki, Yukio Sekiguchi, Kyoko Soejima, Masahiko Takagi, Masaomi Chinushi, Nobuhiro Nishi, Takashi Noda, Hitoshi Hachiya, Masataka Mitsuno, Takeshi Mitsuhashi, Yasushi Miyauchi, Aya Miyazaki, Tomoshige Morimoto, Hiro Yamasaki, Yoshifusa Aizawa, Tohru Ohe, Takeshi Kimura, Kazuo Tanemoto, Hiroyuki Tsutsui, Hideo Mitamura

    Circulation journal : official journal of the Japanese Circulation Society   85 ( 7 )   1104 - 1244   2021.6

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    DOI： 10.1253/circj.CJ-20-0637

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  • 抗ミトコンドリア抗体陽性ミオパチーおよび原発性胆汁性胆管炎患者における心室頻拍の臨床的特徴(The Clinical Features of Ventricular Tachyarrhythmias in Patient with Anti-Mitochondrial Antibody-Associated Myopathy and/or Primary Biliary Cholangitis)

    井神 康宏, 和泉 大輔, 鈴木 尚真, 坂口 裕太, 袴田 崇裕, 長谷川 祐紀, 大槻 総, 飯嶋 賢一, 八木原 伸江, 池主 雅臣, 南野 徹

    日本循環器学会学術集会抄録集   85回   OJ91 - 5   2021.3

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  • CORRIGENDUM: JCS/JHRS 2019 Guideline on Non-Pharmacotherapy of Cardiac Arrhythmias.

    Akihiko Nogami, Takashi Kurita, Haruhiko Abe, Kenji Ando, Toshiyuki Ishikawa, Katsuhiko Imai, Akihiko Usui, Kaoru Okishige, Kengo Kusano, Koichiro Kumagai, Masahiko Goya, Yoshinori Kobayashi, Akihiko Shimizu, Wataru Shimizu, Morio Shoda, Naokata Sumitomo, Yoshihiro Seo, Atsushi Takahashi, Hiroshi Tada, Shigeto Naito, Yuji Nakazato, Takashi Nishimura, Takashi Nitta, Shinichi Niwano, Nobuhisa Hagiwara, Yuji Murakawa, Teiichi Yamane, Takeshi Aiba, Koichi Inoue, Yuki Iwasaki, Yasuya Inden, Kikuya Uno, Michio Ogano, Masaomi Kimura, Shun-Ichiro Sakamoto, Shingo Sasaki, Kazuhiro Satomi, Tsuyoshi Shiga, Tsugutoshi Suzuki, Yukio Sekiguchi, Kyoko Soejima, Masahiko Takagi, Masaomi Chinushi, Nobuhiro Nishi, Takashi Noda, Hitoshi Hachiya, Masataka Mitsuno, Takeshi Mitsuhashi, Yasushi Miyauchi, Aya Miyazaki, Tomoshige Morimoto, Hiro Yamasaki, Yoshifusa Aizawa, Tohru Ohe, Takeshi Kimura, Kazuo Tanemoto, Hiroyuki Tsutsui, Hideo Mitamura

    Circulation journal : official journal of the Japanese Circulation Society   85 ( 9 )   1692 - 1700   2021

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    DOI： 10.1253/circj.CJ-66-0196

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  • Usefulness of the intravenous flecainide challenge test before oral flecainide treatment in a patient with Andersen-Tawil syndrome. Reviewed International journal

    Sato A, Takano T, Chinushi M, Minamino T

    BMJ case reports   12 ( 7 )   2019.7

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    Andersen-Tawil syndrome (ATS) is an inherited disorder characterised by the triad of ventricular arrhythmias (VAs), periodic paralysis and dysmorphic features. A 31-year-old woman diagnosed with ATS caused by a KCNJ2 mutation (p.R228ins) was urgently admitted to our hospital following an episode of syncope during exercise. Electrocardiography revealed frequent premature ventricular complexes and non-sustained ventricular tachycardias (VTs) with pleomorphic QRS patterns. During the intravenous flecainide test (30 mg), the frequent VAs were inhibited completely. After oral flecainide (100 mg) was started, VAs, except for a brief bigeminy, were suppressed during the exercise test. On 24-hour Holter recordings, the VAs decreased from 50 133 to 13 363 beats/day (-73%). Sustained VT and syncope were not observed during a 3-year follow-up period. Intravenous flecainide challenge test may be useful in predicting the efficacy of oral flecainide treatment for patients with ATS.

    DOI： 10.1136/bcr-2019-229628

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  • Asymptomatic Coronary Artery Disease in Japanese Patients With the Acute Ischemic Stroke

    Minoru Tagawa, Shigekazu Takeuchi, Yuichi Nakamura, Makihiko Saeki, Yoshinori Taniguchi, Tsukasa Ohno, Hiroyuki Watanabe, Yukie Ochiai, Kiminori Kato, Masaomi Chinushi, Yoshifusa Aizawa

    Journal of Stroke and Cerebrovascular Diseases   28 ( 3 )   612 - 618   2019.3

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    DOI： 10.1016/j.jstrokecerebrovasdis.2018.10.035

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  • Effects of Direct Oral Anticoagulants at the Peak Phase, Trough Phase, and After Vascular Injury. Reviewed International journal

    Sou Otuki, Daisuke Izumi, Masayoshi Suda, Akinori Sato, Yuki Hasegawa, Nobue Yagihara, Kenichi Iijima, Masaomi Chinushi, Ichiro Fuse, Tohru Minamino

    Journal of the American College of Cardiology   71 ( 1 )   102 - 104   2018.1

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  • Incorrect Holter-ECG analysis caused by the pacemaker delivering small high-frequency currents for thoracic impedance measurement Reviewed

    Masaomi Chinushi, Hitoshi Tachikawa, Yuko Chinushi, Toshio Yamaguchi, Osamu Saitoh, Takashi Tsuda

    Journal of Cardiology Cases   16 ( 6 )   219 - 222   2017.12

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    DOI： 10.1016/j.jccase.2017.08.007

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  • The effects of pure potassium channel blocker nifekalant and sodium channel blocker mexiletine on malignant ventricular tachyarrhythmias Reviewed

    Sou Otuki, Kanae Hasegawa, Hiroshi Watanabe, Goro Katsuumi, Nobue Yagihara, Kenichi Iijima, Akinori Sato, Daisuke Izumi, Hiroshi Furushima, Masaomi Chinushi, Yoshifusa Aizawa, Tohru Minamino

    JOURNAL OF ELECTROCARDIOLOGY   50 ( 3 )   277 - 281   2017.5

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    DOI： 10.1016/j.jelectrocard.2016.09.005

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  • Malignant Form of Idiopathic Ventricular Arrhythmia Originating from the Right Ventricular Outflow Tract Reviewed

    Keiko Sonoda, Hiroshi Watanabe, Masaomi Chinushi, Kanae Hasegawa, Nobue Yagihara, Kenichi Iijima, Akinori Sato, Daisuke Izumi, Hiroshi Furushima, Yoshifusa Aizawa

    journal of arrhythmia   27 ( 4 )   316   2017

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    DOI： 10.4020/jhrs.27.PJ2_085

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  • Sustained ventricular tachycardia developed following successful ablation of target idiopathic left ventricular premature complexes Reviewed

    Minoru Tagawa, Yukie Ochiai, Yuichi Nakamura, Hiroshi Furushima, Masaomi Chinushi

    INTERNATIONAL JOURNAL OF CARDIOLOGY   222   686 - 688   2016.11

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  • Secondly ECG recordings in the emergency room revealed Garenoxacin-induced abnormal QT interval prolongation in a patient with multiple syncopal attacks Reviewed

    Minoru Tagawa, Sachie Ochiai, Yuichi Nakamura, Akinori Sato, Masaomi Chinushi

    HEART AND VESSELS   31 ( 7 )   1200 - 1205   2016.7

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    DOI： 10.1007/s00380-015-0693-x

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  • Regional Differences in Frequency of Warfarin Therapy and Thromboembolism in Japanese Patients With Non-Valvular Atrial Fibrillation - Analysis of the J-RHYTHM Registry Reviewed

    Hiroshi Inoue, Hirotsugu Atarashi, Eitaro Kodani, Ken Okumura, Takeshi Yamashita, Hideki Origasa, Masayuki Sakurai, Yuichiro Kawamura, Isao Kubota, Kazuo Matsumoto, Yoshiaki Kaneko, Satoshi Ogawa, Yoshifusa Aizawa, Masaomi Chinushi, Itsuo Kodama, Eiichi Watanabe, Yukihiro Koretsune, Yuji Okuyama, Akihiko Shimizu, Osamu Igawa, Shigenobu Bando, Masahiko Fukatani, Tetsunori Saikawa, Akiko Chishaki

    CIRCULATION JOURNAL   80 ( 7 )   1548 - 1555   2016.7

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    DOI： 10.1253/circj.CJ-16-0300

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  • Role of left and right side renal sympathetic nerve activity for systemic blood pressure modulation (electrical nerve stimulation and radiofrequency catheter ablation in an experimental model)

    Chinushi Masaomi, Suzuki Katsuya, Saitoh Osamu, Ooya Kana, Iijima Kenichi, Sato Akinori, Izumi Daisuke, Sugai Mika, Furushima Hiroshi

    Shinzo   48 ( 6 )   608 - 616   2016.6

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    腎動脈アブレーションでは両側腎動脈に高周波通電が行われているが, その根拠は明らかにされていない. 高周波通電が両側腎動脈に行われる理由を検証するため動物実験を行った. ビーグル犬を用いて血圧調整における左右腎交感神経興奮の効果を, 腎動脈高周波アブレーション前後の神経電気刺激の昇圧反応から検討した. 腎動脈にイリゲーションカテーテルを挿入して高周波通電を片側腎動脈に行い, 先端電極からの神経電気刺激をアブレーション前後で施行した. アブレーション前の神経電気刺激で昇圧速脈反応が左右腎動脈で同程度に誘発され, 心拍変動解析の交感神経指標と血中カテコラミン値も上昇した. アブレーションを施行した腎動脈では神経電気刺激による昇圧速脈反応は観察されなくなったが, アブレーションをしなかった腎動脈の神経電気刺激では, アブレーション前と同等の昇圧速脈反応が再度誘発された. 腎交感神経刺激による全身交感神経緊張は左右腎動脈で同等に生じ, 一側腎動脈アブレーションは, 対側腎動脈刺激の昇圧速脈誘発に影響を与えなかった. 腎動脈アブレーションで成果を得るには, 両側腎動脈通電が望まれることを支持する所見と思われる.&lt;/p&gt;

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  • Autonomic Nerve Activity and Ventricular Tachyarrhythmias Associated with Structural Heart Diseases

    Chinushi Masaomi, Saitoh Osamu, Okuda Akiko, Furushima Hiroshi

    Japanese Journal of Electrocardiology   36 ( 1 )   31 - 37   2016

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    DOI： 10.5105/jse.36.31

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    Other Link： http://search.jamas.or.jp/link/ui/2016172097

  • Non-valvular atrial fibrillation patients with low CHADS2 scores benefit from warfarin therapy according to propensity score matching subanalysis using the J-RHYTHM Registry Reviewed

    Akiko Chishaki, Naoko Kumagai, Naohiko Takahashi, Tetsunori Saikawa, Hiroshi Inoue, Ken Okumura, Hirotsugu Atarashi, Takeshi Yamashita, Hideki Origasa, Masayuki Sakurai, Yuichiro Kawamura, Isao Kubota, Kazuo Matsumoto, Yoshiaki Kaneko, Satoshi Ogawa, Yoshifusa Aizawa, Masaomi Chinushi, Itsuo Kodama, Eiichi Watanabe, Yukihiro Koretsune, Yuji Okuyama, Akihiko Shimizu, Osamu Igawa, Shigenobu Bando, Masahiko Fukatani

    THROMBOSIS RESEARCH   136 ( 2 )   267 - 273   2015.8

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    DOI： 10.1016/j.thromres.2015.06.009

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  • Effects of combination therapy with nifekalant and mexiletine on electrical storm Reviewed

    S. Otuki, K. Hasegawa, H. Watanabe, N. Yagihara, K. Iijima, A. Sato, D. Izumi, H. Furushima, M. Chinushi, T. Minamino

    EUROPEAN HEART JOURNAL   36   1068 - 1068   2015.8

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  • 非ブルガダ型特発性心室細動患者における心室細動の概日パターンとそのJ波との関連性(Circadian Pattern of Ventricular Fibrillation in Patients with Non-Brugada-type Idiopathic Ventricular Fibrillation and Its Association with J Waves)

    Aizawa Yoshiyasu, Sato Masahito, Ohno Seiko, Horie Minoru, Takatsuki Seiji, Fukuda Keiichi, Chinushi Masaomi, Usui Tatsuya, Aonuma Kazutaka, Hosaka Yukio, Michel Haissaguerre, Aizawa Yoshifusa

    Circulation Journal   79 ( Suppl.I )   691 - 691   2015.3

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  • Frequency Characteristics and Associations with the Defibrillation Threshold of Ventricular Fibrillation in Patients with Implantable Cardioverter Defibrillators Reviewed

    Kenichi Iijima, Masaomi Chinushi, Osamu Saitoh, Kanae Hasegawa, Keiko Sonoda, Nobue Yagihara, Akinori Sato, Daisuke Izumi, Hiroshi Watanabe, Hiroshi Furushima, Yoshifusa Aizawa, Tohru Minamino

    INTERNAL MEDICINE   54 ( 10 )   1175 - 1182   2015

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    DOI： 10.2169/internalmedicine.54.3113

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  • Circadian pattern of fibrillatory events in non-Brugada-type idiopathic ventricular fibrillation with a focus on J waves Reviewed

    Yoshiyasu Aizawa, Masahito Sato, Seiko Ohno, Minoru Hone, Seiji Takatsuki, Keiichi Fukuda, Masaomi Chinushi, Tatsuya Usui, Kazutaka Aonuma, Yukio Hosaka, Michel Haissaguerre, Yoshifusa Aizawa

    HEART RHYTHM   11 ( 12 )   2261 - 2266   2014.12

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    DOI： 10.1016/j.hrthm.2014.08.022

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  • 心拍変動に伴うQT間隔のダイナミクス トレッドミル運動負荷試験を用いた検討

    鈴木 克弥, 齋藤 修, 阪井 絵理伽, 渡邊 美友貴, 道村 玲香, 阿部 望, 奈良 佳輝, 田中 勇気, 末永 有香, 飯沼 裕美, 神林 真弓, 大井 恵子, 大矢 佳奈, 加藤 公則, 津田 隆志, 池主 雅臣

    新潟県臨床検査技師会誌   54 ( 4 )   212 - 216   2014.10

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    トレッドミル運動負荷試験中のQT間隔の変動がBazett補正式で適正に補正されるか検討した。対象は健常者226名とし、運動によるQT/QTc間隔のダイナミクスを回帰曲線式で分析した。結果、安静臥位から立位への体位変化または運動中の心拍数増加に伴ってBazett補正によるQTc間隔が適正範囲を逸脱した者が23%存在した。

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  • 時系列コンピュータ解析によるJ波高の定量的評価 日内変動における自律神経興奮の関わり

    新潟県臨床検査技師会誌   54 ( 3 )   150 - 154   2014.7

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  • Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome Reviewed

    Goro Katsuumi, Wataru Shimizu, Hiroshi Watanabe, Takashi Noda, Akihiko Nogami, Kimie Ohkubo, Takeru Makiyama, Naofumi Takehara, Yuichiro Kawamura, Yukio Hosaka, Masahito Sato, Satoki Fukae, Masaomi Chinushi, Hirotaka Oda, Masaaki Okabe, Akinori Kimura, Koji Maemura, Ichiro Watanabe, Shiro Kamakura, Minoru Horie, Yoshifusa Aizawa, Naomasa Makita, Tohru Minamino

    INTERNATIONAL JOURNAL OF CARDIOLOGY   172 ( 2 )   519 - 522   2014.3

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  • Augmentation of the J wave by rapid pacing in a patient with vasospastic angina Reviewed

    Akinori Sato, Hiroshi Watanabe, Keiko Sonoda, Masaomi Chinushi, Takashi Tsuda, Daisuke Izumi, Hiroshi Furushima, Tohru Minamino

    INTERNATIONAL JOURNAL OF CARDIOLOGY   172 ( 1 )   E111 - E113   2014.3

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  • Impact of Gender on the Prognosis of Patients With Nonvalvular Atrial Fibrillation Reviewed

    Hiroshi Inoue, Hirotsugu Atarashi, Ken Okumura, Takeshi Yamashita, Hideki Origasa, Naoko Kumagai, Masayuki Sakurai, Yuichiro Kawamura, Isao Kubota, Kazuo Matsumoto, Yoshiaki Kaneko, Satoshi Ogawa, Yoshifusa Aizawa, Masaomi Chinushi, Itsuo Kodama, Eiichi Watanabe, Yukihiro Koretsune, Yuji Okuyama, Akihiko Shimizu, Osamu Igawa, Shigenobu Bando, Masahiko Fukatani, Tetsunori Saikawa, Akiko Chishaki

    AMERICAN JOURNAL OF CARDIOLOGY   113 ( 6 )   957 - 962   2014.3

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    DOI： 10.1016/j.amjcard.2013.11.057

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  • Efficacy of Bepridil to Prevent Ventricular Fibrillation in Early Repolarization Syndrome Reviewed

    Katsuumi Goro, Shimizu Wataru, Watanabe Hiroshi, Noda Takashi, Nogami Akihiko, Ohkubo Kimie, Takehara Naofumi, Kawamura Yuichiro, Hosaka Yukio, Makiyama Takeru, Sato Masahito, Fukae Satoki, Chinushi Masaomi, Oda Hirotaka, Okabe Masaaki, Kimura Akinori, Maemura Koji, Watanabe Ichiro, Kamakura Shiro, Horie Minoru, Aizawa Yoshifusa, Makita Naomasa, Minamino Tohru

    CIRCULATION   128 ( 22 )   2013.11

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  • Target International Normalized Ratio Values for Preventing Thromboembolic and Hemorrhagic Events in Japanese Patients With Non-Valvular Atrial Fibrillation - Results of the J-RHYTHM Registry (vol 77, pg 2264, 2013) Reviewed

    Hiroshi Inoue, Ken Okumura, Hirotsugu Atarashi, Takeshi Yamashita, Hideki Origasa, Naoko Kumagai, Masayuki Sakurai, Yuichiro Kawamura, Isao Kubota, Kazuo Matsumoto, Yoshiaki Kaneko, Satoshi Ogawa, Yoshifusa Aizawa, Masaomi Chinushi, Itsuo Kodama, Eiichi Watanabe, Yukihiro Koretsune, Yuji Okayama, Akihiko Shimizu, Osamu Igawa, Shigenobu Bando, Masahiko Fukatani, Tetsunori Saikawa, Akiko Chishaki

    CIRCULATION JOURNAL   77 ( 11 )   2848 - 2848   2013.11

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  • Electrical storm in idiopathic ventricular fibrillation is associated with early repolarization Reviewed

    Yoshifusa Aizawa, Masaomi Chinushi, Kanae Hasegawa, Nobu Naiki, Minoru Horie, Yoshiaki Kaneko, Masahiko Kurabayashi, Shogo Ito, Tsutomu Imaizumi, Yoshiyasu Aizawa, Seiji Takatsuki, Kunitake Joo, Masahito Sato, Katsuya Ebe, Yukio Hosaka, Michel Haissaguerre, Keiichi Fukuda

    Journal of the American College of Cardiology   62 ( 11 )   1015 - 1019   2013.9

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    DOI： 10.1016/j.jacc.2013.05.030

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  • Ventricular fibrillation associated with complete right bundle branch block Reviewed

    Yoshiyasu Aizawa, Seiji Takatsuki, Takehiro Kimura, Nobuhiro Nishiyama, Kotaro Fukumoto, Yoko Tanimoto, Kojiro Tanimoto, Shunichiro Miyoshi, Makoto Suzuki, Yasuhiro Yokoyama, Masaomi Chinushi, Ichiro Watanabe, Satoshi Ogawa, Yoshifusa Aizawa, Charles Antzelevitch, Keiichi Fukuda

    HEART RHYTHM   10 ( 7 )   1028 - 1035   2013.7

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    DOI： 10.1016/j.hrthm.2013.03.013

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  • Short-coupling premature ventricular complexes from the left ventricle triggered isoproterenol-resistant electrical storm in a patient with Brugada syndrome Reviewed

    Masaomi Chinushi, Kenichi Iijima, Akinori Sato, Hiroshi Furushima

    HEART RHYTHM   10 ( 6 )   916 - 920   2013.6

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    DOI： 10.1016/j.hrthm.2013.01.020

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  • Suppression of Storms of Ventricular Tachycardia by Epicardial Ablation of Isolated Delayed Potential in Noncompaction Cardiomyopathy Reviewed

    Masaomi Chinushi, Kenichi Iijima, Hiroshi Furushima, Daisuke Izumi, Akinori Sato, Nobue Yagihara, Kanae Hasegawa, Hiroshi Watanabe, Kyoko Soejima, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   36 ( 4 )   e115 - e119   2013.4

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  • [Arrhythmia and genetic background]. Reviewed

    Chinushi M, Sato A

    Rinsho byori. The Japanese journal of clinical pathology   61 ( 2 )   150 - 158   2013.2

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  • Guidelines for Clinical Cardiac Electrophysiologic Studies (JCS 2011) - Digest Version - JCS Joint Working Group Reviewed

    Satoshi Ogawa, Yoshifusa Aizawa, Kazutaka Aonuma, Makoto Hirai, Yoshito Iesaka, Hiroshi Inoue, Toshiyuki Ishikawa, Shiro Kamakura, Takao Kato, Youichi Kobayashi, Yoshio Kosakai, Koichiro Kumagai, Takashi Kurita, Yuji Nakazato, Ken Okumura, Morio Shoda, Kaoru Sugi, Naokata Sumitomo, Seiji Takatsuki, Kan Takayanagi, Ichiro Watanabe, Masaomi Chinushi, Akira Fujiki, Atsushi Iwasa, Yoshinori Kobayashi, Keisuke Kuga, Satoshi Nagase, Satoshi Ohnishi, Kazuhiro Satomi, Kaoru Tanno, Masayuki Yasuda, Hiroyuki Daida, Kazumasa Hiejima, Hiroshi Kasanuki, Takuro Misaki, Tohru Ohe

    CIRCULATION JOURNAL   77 ( 2 )   497 - 518   2013.2

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  • Ventricular repolarization gradient and electrocardiogram characteristics of Tako-Tsubo cardiomyopathy Reviewed

    Masaomi Chinushi

    HEART RHYTHM   10 ( 1 )   78 - 79   2013.1

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  • Amiodarone-related sinoatrial node dysfunction and its implications in the treatment of atrial fibrillation Reviewed

    Masaomi Chinushi

    Circulation Journal   77 ( 9 )   2240 - 2241   2013

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    DOI： 10.1253/circj.CJ-13-0878

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  • Target international normalized ratio values for preventing thromboembolic and hemorrhagic events in Japanese patients with non-valvular atrial fibrillation: results of the J-RHYTHM Registry. Reviewed

    Hiroshi Inoue, Ken Okumura, Hirotsugu Atarashi, Takeshi Yamashita, Hideki Origasa, Naoko Kumagai, Masayuki Sakurai, Yuichiro Kawamura, Isao Kubota, Kazuo Matsumoto, Yoshiaki Kaneko, Satoshi Ogawa, Yoshifusa Aizawa, Masaomi Chinushi, Itsuo Kodama, Eiichi Watanabe, Yukihiro Koretsune, Yuji Okuyama, Akihiko Shimizu, Osamu Igawa, Shigenobu Bando, Masahiko Fukatani, Tetsunori Saikawa, Akiko Chishaki

    Circulation journal : official journal of the Japanese Circulation Society   77 ( 9 )   2264 - 70   2013

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    DOI： 10.1253/circj.CJ-13-0290

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  • Malfunction of cardiac resynchronization therapy due to subsequent fracture of the ring and tip conductors of a co-radial left ventricular bipolar lead Reviewed

    Akinori Sato, Masaomi Chinushi, Daisuke Izumi, Hiroshi Furushima, Tohru Minamino

    Internal Medicine   52 ( 11 )   1189 - 1193   2013

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    DOI： 10.2169/internalmedicine.52.8988

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  • Incessant ventricular tachyarrhythmia in the emergency room Reviewed

    Masaomi Chinushi, Akinori Sato

    Journal of Cardiology Cases   6 ( 6 )   e185 - e186   2012.12

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    DOI： 10.1016/j.jccase.2012.09.001

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  • Novel KCNQ1 Missense Mutation Associated with Juvenile-Onset Atrial Fibrillation Reviewed

    Kanae Hasegawa, Seiko Ohno, Hideki Itoh, Tetuhisa Hattori, Takeru Makiyama, Futoshi Toyoda, Wei-Guang Ding, Masaomi Chinushi, Hiroshi Matsuura, Minoru Horie

    CIRCULATION   126 ( 21 )   2012.11

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  • Radiofrequency Catheter Ablation to Ventricular Tachycardia with Tetoralogy of Fallot Usefulness of Ablation to Narrow Channel of Macroreentrant Circuit Around Ventricular Septal Patch Reviewed

    Hiroshi Furushima, Masaomi Chinushi, Hiroshi Watanabe, Daisuke Izumi, Akinori Sato, Kenichi Iijima

    CIRCULATION   126 ( 21 )   2012.11

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  • Correlation between Defibrillation Threshold and Dominant Frequency of Ventricular Fibrillation Reviewed

    Kenichi Iijima, Akinori Sato, Daisuke Izumi, Hiroshi Watanabe, Hiroshi Furushima, Masaomi Chinushi

    CIRCULATION   126 ( 21 )   2012.11

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  • Hemodynamic Responses and Histological Effects of Radiofrequency Catheter Ablation to Renal Artery Sympathetic Nerve Reviewed

    Masaomi Chinushi, Daisuke Izumi, Kenichi Iijima, Katuya Suzuki, Hiroshi Furushima, Yoshifusa Aizawa, Mitsuya Iwafuchi

    CIRCULATION   126 ( 21 )   2012.11

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  • Clinical characteristics and risk of arrhythmia recurrences in patients with idiopathic ventricular fibrillation associated with early repolarization Reviewed

    Hiroshi Watanabe, Akihiko Nogami, Kimie Ohkubo, Hiro Kawata, Yuka Hayashi, Taisuke Ishikawa, Takeru Makiyama, Satomi Nagao, Nobue Yagihara, Naofumi Takehara, Yuichiro Kawamura, Akinori Sato, Kazuki Okamura, Yukio Hosaka, Masahito Sato, Satoki Fukae, Masaomi Chinushi, Hirotaka Oda, Masaaki Okabe, Akinori Kimura, Koji Maemura, Ichiro Watanabe, Shiro Kamakura, Minoru Horie, Yoshifusa Aizawa, Wataru Shimizu, Naomasa Makita

    INTERNATIONAL JOURNAL OF CARDIOLOGY   159 ( 3 )   238 - 240   2012.9

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  • Nifekalant Enlarged the Transmural Activation-Recovery Interval Difference as Well as the Peak-to-End Interval on Surface ECG in a Patient with Short-QT Syndrome Reviewed

    Masaomi Chinushi, Akinori Sato, Daisuke Izumi, Hiroshi Furushima

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   23 ( 8 )   877 - 880   2012.8

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    DOI： 10.1111/j.1540-8167.2012.02292.x

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  • Early Repolarization and Its Modification by Preexcitation in Two Patients with Intermittent Wolff-Parkinson-White Syndrome Reviewed

    Kanae Hasegawa, Akinori Sato, Hiroshi Watanabe, Hiroshi Furushima, Masaomi Chinushi, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   35 ( 8 )   e231 - e233   2012.8

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    DOI： 10.1111/j.1540-8159.2012.03360.x

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  • Exercise-Related QT Interval Shortening with a Peaked T Wave in a Healthy Boy with a Family History of Sudden Cardiac Death Reviewed

    Masaomi Chinushi, Akinori Sato, Kenichi Iijima, Katuya Suzuki, Furushima Hiroshi, Daisuke Izumi, Hiroshi Watanabe, Hasegawa Kanae, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   35 ( 8 )   e239 - e242   2012.8

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  • Characteristics of J Wave-Associated Idiopathic Ventricular Fibrillation: Role of Drugs Reviewed

    Masaomi Chinushi, Kanae Hasegawa, Kenichi Iijima, Hiroshi Furushima, Daisuke Izumi, Akinori Sato, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   35 ( 8 )   e226 - e230   2012.8

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  • Recurrence of ventricular fibrillation in a patient with non-type 1 Brugada electrocardiographic morphology. Reviewed

    Tagawa M, Chinushi M, Nakamura Y, Ochiai Y, Sato A, Iijima K, Uchiyama H, Furushima H, Aizawa Y

    Journal of cardiology cases   6 ( 1 )   e17 - e19   2012.7

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  • Epicardial and endocardial mapping determine most successful site of ablation for ventricular tachyarrhythmias originating from left ventricular summit Reviewed

    Kenichi Iijima, Masaomi Chinushi, Hiroshi Furushima, Yoshifusa Aizawa

    EUROPACE   14 ( 6 )   911 - 912   2012.6

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  • KCNQ1複合ヘテロ接合体のJervell and Lange-Nielsen症候群(JLNS)の女児例

    羽二生 尚訓, 渡辺 健一, 沼野 藤人, 鈴木 博, 佐藤 光希, 池主 雅臣, 渡辺 マヤ, 白石 修一, 高橋 昌

    日本小児循環器学会雑誌   28 ( Suppl. )   s304 - s304   2012.6

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  • Dynamicity of the J-Wave in Idiopathic Ventricular Fibrillation With a Special Reference to Pause-Dependent Augmentation of the J-Wave Reviewed

    Yoshifusa Aizawa, Akinori Sato, Hiroshi Watanabe, Masaomi Chinushi, Hiroshi Furushima, Minoru Horie, Yoshiaki Kaneko, Tsutomu Imaizumi, Kimie Okubo, Ichiro Watanabe, Tsuyoshi Shinozaki, Yoshiyasu Aizawa, Keiichi Fukuda, Kunitake Joo, Michel Haissaguerre

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   59 ( 22 )   1948 - 1953   2012.5

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  • Analysis of J waves during myocardial ischaemia Reviewed

    Akinori Sato, Yasuhiko Tanabe, Masaomi Chinushi, Yuka Hayashi, Tsuyoshi Yoshida, Eiichi Ito, Daisuke Izumi, Kenichi Iijima, Nobue Yagihara, Hiroshi Watanabe, Hiroshi Furushima, Yoshifusa Aizawa

    EUROPACE   14 ( 5 )   715 - 723   2012.5

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  • Characteristics of electrocardiographic repolarization in acute myocardial infarction complicated by ventricular fibrillation Reviewed

    Yoshifusa Aizawa, Marek Jastrzebski, Takuya Ozawa, Kalina Kawecka-Jaszcz, Piotr Kukla, Wataru Mitsuma, Masaomi Chinushi, Toru Ida, Yoshiyasu Aizawa, Kenji Ojima, Minoru Tagawa, Satoru Fujita, Masaaki Okabe, Keiichi Tsuchida, Yasushi Miyakita, Hiroshi Shimizu, Shogo Ito, Tsutomu Imaizumi, Ken Toba

    JOURNAL OF ELECTROCARDIOLOGY   45 ( 3 )   252 - 259   2012.5

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  • Epicardial Scar in a Patient with no Apparent Heart Disease Reviewed

    Masaomi Chinushi, Daisuke Izumi, Hiroshi Furushima, Akinori Sato, Kenichi Iijima, Kanae Hasegawa, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   35 ( 5 )   e136 - e139   2012.5

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    DOI： 10.1111/j.1540-8159.2011.03142.x

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  • Significance and usefulness of heart rate variability in patients with multiple system atrophy Reviewed

    Hiroshi Furushima, Takayoshi Shimohata, Hideaki Nakayama, Tetsutaro Ozawa, Masaomi Chinushi, Yoshifusa Aizawa, Masatoyo Nishizawa

    MOVEMENT DISORDERS   27 ( 4 )   570 - 574   2012.4

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  • Electrocardiographic Characteristics and SCN5A Mutations in Idiopathic Ventricular Fibrillation Associated With Early Repolarization Response Reviewed

    Hiroshi Watanabe, Akihiko Nogami, Kimie Ohkubo, Hiro Kawata, Yuka Hayashi, Taisuke Ishikawa, Takeru Makiyama, Satomi Nagao, Nobue Yagihara, Naofumi Takehara, Yuichiro Kawamura, Akinori Sato, Kazuki Okamura, Yukio Hosaka, Masahito Sato, Satoki Fukae, Masaomi Chinushi, Hirotaka Oda, Masaaki Okabe, Akinori Kimura, Koji Maemura, Ichiro Watanabe, Shiro Kamakura, Minoru Horie, Yoshifusa Aizawa, Wataru Shimizu, Naomasa Makita

    CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY   5 ( 2 )   E60 - E61   2012.4

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  • Relationship between electroanatomical voltage mapping characteristics and breakout site of ventricular activation in idiopathic ventricular tachyarrhythmia originating from the right ventricular outflow tract septum Reviewed

    Hiroshi Furushima, Masaomi Chinushi, Kenichi Iijima, Daisuke Izumi, Yukio Hosaka, Yoshifusa Aizawa

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   33 ( 2 )   135 - 141   2012.3

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    DOI： 10.1007/s10840-011-9623-8

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  • Guidelines for Risks and Prevention of Sudden Cardiac Death (JCS 2010) - Digest Version Reviewed

    Yoshifusa Aizawa, Minoru Horie, Hirosh Inoue, Shiro Kamakura, Takao Katoh, Masunori Matsuzaki, Takuro Misaki, Hideo Mitamura, Yuji Murakawa, Takashi Nitta, Satoshi Ogawa, Ken Okumura, Naokata Sumitomo, Masao Yoshinaga, Masaomi Chinushi, Akira Fujiki, Hiroshi Furushima, Takanori Ikeda, Makoto Ito, Keisuke Kuga, Kengo Kusano, Shinich Niwano, Ryuji Nohara, Shingo Sasaki, Akihiko Shimizu, Wataru Shimizu, Morio Shoda, Masatsugu Hori, Makoto Nakazawa, Tsuneaki Sugimoto, Tetsu Yamaguchi

    CIRCULATION JOURNAL   76 ( 2 )   489 - 507   2012.2

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  • Intramural inflammation as a cause of transient ST-segment elevation in a patient of cardiac sarcoidosis Reviewed

    Kenichi Iijima, Masaomi Chinushi, Hiroshi Furushima, Yoshifusa Aizawa

    EUROPACE   14 ( 2 )   300 - 302   2012.2

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  • The prevalence of early repolarization in Wolff-Parkinson-White syndrome with a special reference to J waves and the effects of catheter ablation Reviewed

    Nobue Yagihara, Akinori Sato, Kenichi Iijima, Daisuke Izumi, Hiroshi Furushima, Hiroshi Watanabe, Tadanobu Irie, Yoshiaki Kaneko, Masahiko Kurabayashi, Masaomi Chinushi, Masahito Satou, Yoshifusa Aizawa

    JOURNAL OF ELECTROCARDIOLOGY   45 ( 1 )   36 - 42   2012.1

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  • Benign Premature Ventricular Complexes from the Right Ventricular Outflow Tract Triggered Polymorphic Ventricular Tachycardia in a Latent Type 2 LQTS Patient Reviewed

    Akinori Sato, Masaomi Chinushi, Keiko Sonoda, Akira Abe, Daisuke Izumi, Hiroshi Furushima

    INTERNAL MEDICINE   51 ( 23 )   3261 - 3265   2012

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  • Post-exercise Cardiac Asystole in a Young Competitive Athlete Reviewed

    Masahiro Ito, Kanae Hasegawa, Masaaki Arakawa, Masaomi Chinushi

    INTERNAL MEDICINE   51 ( 8 )   979 - 979   2012

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  • Insulation Defects in Riata Implantable Cardioverter-defibrillator Leads Reviewed

    Akinori Sato, Masaomi Chinushi, Kenichi Iijima, Daisuke Izumi, Hiroshi Furushima

    INTERNAL MEDICINE   51 ( 19 )   2689 - 2694   2012

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  • Long QT Syndrome with Nocturnal Cardiac Events Caused by a KCNH2 Missense Mutation (G604S) Reviewed

    Akinori Sato, Masaomi Chinushi, Hiroshi Suzuki, Fujito Numano, Takanori Hanyu, Kenichi Iijima, Hiroshi Watanabe, Hiroshi Furushima

    INTERNAL MEDICINE   51 ( 14 )   1857 - 1860   2012

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  • A case report；Drug-refractory vasospastic angina associated with pulseless electrical activity

    Takayama Tsugumi, Chinushi Masaomi, Arita Tadataka, Sonoda Keiko, Iijima Kenichi, Sato Akinori, Kashimura Ken, Izumi Daisuke, Watanabe Hiroshi, Furushima Hiroshi, Kodama Makoto, Aizawa Yoshihusa

    Shinzo   44 ( 2 )   S2_87 - S2_91   2012

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    DOI： 10.11281/shinzo.44.S2_87

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  • Electrocardiographic Characteristics and SCN5A Mutations in Idiopathic Ventricular Fibrillation Associated With Early Repolarization Reviewed

    Hiroshi Watanabe, Akihiko Nogami, Kimie Ohkubo, Hiro Kawata, Yuka Hayashi, Taisuke Ishikawa, Takeru Makiyama, Satomi Nagao, Nobue Yagihara, Naofumi Takehara, Yuichiro Kawamura, Akinori Sato, Kazuki Okamura, Yukio Hosaka, Masahito Sato, Satoki Fukae, Masaomi Chinushi, Hirotaka Oda, Masaaki Okabe, Akinori Kimura, Koji Maemura, Ichiro Watanabe, Shiro Kamakura, Minoru Horie, Yoshifusa Aizawa, Wataru Shimizu, Naomasa Makita

    CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY   4 ( 6 )   874 - 881   2011.12

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    DOI： 10.1161/CIRCEP.111.963983

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  • A Novel Mutation in a Lamin A/C Gene Associated with Dilated Cardiomyopathy, Degeneration of Cardiac Conduction System, and Altered Gene Expression Reviewed

    Nobue Yagihara, Keiko Sonoda, Hiroshi Watanabe, Hiroaki Obata, Akinori Sato, Masaomi Chinushi, Haruo Hanawa, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Makoto Kodama

    CIRCULATION   124 ( 21 )   2011.11

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  • Brugada-Type ST-Segment Elevation Influenced by Postesophageal Reconstruction Reviewed

    Masaomi Chinushi, Yukako Ohno, Akiko Sanada, Yoshifusa Aizawa

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   22 ( 11 )   1292 - 1293   2011.11

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  • Ventricular Tachycardia Due to Intramyocardial Fibroma Reviewed

    Kenichi Iijima, Masaomi Chinushi, Daisuke Izumi, Yoshifusa Aizawa

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   22 ( 7 )   825 - 826   2011.7

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  • Role of mineralocorticoid receptor on atrial structural remodeling and inducibility of atrial fibrillation in hypertensive rats Reviewed

    Shinpei Kimura, Masahiro Ito, Makoto Tomita, Makoto Hoyano, Hiroaki Obata, Limin Ding, Masaomi Chinushi, Haruo Hanawa, Makoto Kodama, Yoshifusa Aizawa

    HYPERTENSION RESEARCH   34 ( 5 )   584 - 591   2011.5

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  • Preexcitation unmasks J waves: 2 cases Reviewed

    Satomi Nagao, Yuka Hayashi, Nobue Yagihara, Akinori Sato, Hiroshi Watanabe, Hiroshi Furushima, Masaomi Chinushi, Yoshifusa Aizawa

    JOURNAL OF ELECTROCARDIOLOGY   44 ( 3 )   359 - 362   2011.5

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  • Catheter Ablation of Ventricular Tachycardias Due to Forward and Reverse Propagation Across a Reentrant Circuit Inside a Nonischemic Biventricular Aneurysm Reviewed

    Masaomi Chinushi, Daisuke Izumi, Hiroshi Furushima, Yoshifusa Aizawa

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   22 ( 4 )   467 - 471   2011.4

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    DOI： 10.1111/j.1540-8167.2010.01888.x

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  • Rate Control Is a Better Initial Treatment for Patients With Atrial Fibrillation and Heart Failure - Rhythm Control vs. Rate Control: Which Is Better in the Management of Atrial Fibrillation? (Rate-Side) Reviewed

    Masaomi Chinushi, Kenichi Iijima

    CIRCULATION JOURNAL   75 ( 4 )   970 - 978   2011.4

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    DOI： 10.1253/circj.CJ-11-0080

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  • Ventricular Fibrillation and Ventricular Tachycardia Triggered by Late-Coupled Ventricular Extrasystoles in a Brugada Syndrome Patient Reviewed

    Masaomi Chinushi, Hiroshi Furushima, Yukio Hosaka, Daisuke Izumi, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   34 ( 1 )   e1 - e5   2011.1

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    DOI： 10.1111/j.1540-8159.2010.02735.x

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  • An Appropriate Defibrillation Threshold Obtained by the Combined Connection Between Two Shock Leads and ICD Generator Reviewed

    Akinori Sato, Masaomi Chinushi, Kenichi Iijima, Hiroshi Watanabe, Daisuke Izumi, Hiroshi Furushima, Keiko Sonoda, Kanae Hasegawa, Nobue Yagihara, Yoshifusa Aizawa

    INTERNAL MEDICINE   50 ( 22 )   2815 - 2818   2011

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    DOI： 10.2169/internalmedicine.50.5792

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  • Endocardial Arrhythmogenic Mechanisms of Torsades de Pointes in Patients with the Congenital Long QT Syndrome Reviewed

    Masaomi Chinushi, Hiroshi Furushima, Yukio Hosaka, Satoru Komura, Akinori Sato, Kenichi Iijima, Yoshifusa Aizawa

    INTERNAL MEDICINE   50 ( 16 )   1695 - 1702   2011

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    DOI： 10.2169/internalmedicine.50.5114

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  • Inappropriate Pacing Inhibition Triggered by QT Prolongation due to T Wave Oversensing in an ICD Recipient Presenting with Long QT Syndrome Reviewed

    Kenichi Iijima, Masaomi Chinushi, Kanae Hasegawa, Daisuke Izumi, Yukio Hosaka, Hiroshi Furushima, Yoshifusa Aizawa

    INTERNAL MEDICINE   50 ( 9 )   1021 - 1024   2011

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    DOI： 10.2169/internalmedicine.50.4837

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  • Characteristics of Ventricular Tachycardia in Drug-Refractory Electrical Storm in ICD Patients with Structural Heart Disease Reviewed

    Hiroshi Furushima, Masaomi Chinushi, Keiko Sonoda, Kanae Hasegawa, Nobue Yagihara, Kenichi Iijima, Akinori Sato, Daisuke Izumi, Hiroshi Watanabe, Yoshifusa Aizawa

    journal of arrhythmia   27   194   2011

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    DOI： 10.4020/jhrs.27.OP06_3

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  • Incidence and Management for Trouble-Shooting Associated with the Sprint-Fidelis ICD Lead Reviewed

    Kenichi Iijima, Masaomi Chinushi, Akinori Sato, Yukio Hosaka, Daisuke Izumi, Hiroshi Furushima, Hiroshi Watanabe, Masahito Sato, Katsuya Ebe, Hiroshi Shimizu, Kazuyoshi Takahashi, Yoshifusa Aizawa

    Journal of Arrhythmia   27   2011

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    DOI： 10.4020/jhrs.27.OP53_2

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  • Association of J-Wave with Atrial Fibrillation in Wolff-Parkinson-White Syndrome Reviewed

    Nobue Yagihara, Masaomi Chinushi, Hiroshi Furushima, Hiroshi Watanabe, Daisuke Izumi, Akinori Sato, Kenichi Iijima, Tadanori Irie, Yoshiaki Kaneko, Masahiko Kurabayashi, Masahito Sato, Yoshifusa Aizawal

    Journal of Arrhythmia   27   2011

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    DOI： 10.4020/jhrs.27.OP52_3

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  • Impact of Mid-Niigata Prefecture Earthquake on Cardiovascular Diseases Reviewed

    Masaomi Chinushi, Hiroshi Watanabe, Masahito Sato, Yuichi Nakamura, Tsuneo Nagai, Masaaki Okabe, Naohito Tanabe, Makoto Kodama, Hiroshi Furushima, Yoshifusa Aizawa

    journal of arrhythmia   27 ( 4 )   399   2011

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    DOI： 10.4020/jhrs.27.AHJS_5

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  • The Effectiveness of Nifekalant Hydrocholoride for Treatment of Refractory Ventricular Arrhythmia Reviewed

    Minoru Tagawa, Masaomi Chinushi, Yukie Ochiai, Yuichi Nakamura, Yoshifusa Aizawa

    journal of arrhythmia   27   189   2011

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    DOI： 10.4020/jhrs.27.OP02_2

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  • Magnesium Treatment for Drug-Induced QT Prolongation Reviewed

    Daisuke Izumi, Masaomi Chinushi, Kenichi Lijima, Kanae Hasegawa, Akinori Sato, Hiroshi Furushima, Yoshifusa Aizawa

    journal of arrhythmia   27 ( 4 )   297   2011

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    DOI： 10.4020/jhrs.27.PJ2_043

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  • ST-T Abnormalities on ECG in Relation to Cardiovascular Risk Factors Reviewed

    Yuko Chinushi, Hiroshi Watanabe, Masaomi Chinushi, Yoshifusa Aizawa, Aizawa

    Journal of Arrhythmia   27 ( 3 )   202 - 207   2011

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  • An Appropriate Defibrillation Threshold Obtained by the Combined Connection between Two Shock Leads and ICD Generator

    Sato Akinori, Chinushi Masaomi, Iijima Kenichi, Watanabe Hiroshi, Izumi Daisuke, Furushima Hiroshi, Hasegawa Kanae, Yagihara Nobue, Aizawa Yoshifusa

    J Arrhythmia   27   PJ2_070   2011

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    A 60-year-old man with arrhythmogenic right ventricular cardiomyopathy was readmitted to exchange the battery of his implantable cardioverter-defibrillator (ICD). When a dual-chamber ICD was implanted 6 years ago, induced ventricular fibrillation (VF) was terminated successfully by a 20-joule shock. Since (1) he had been treated with a dual-coil shock lead (Sprint Fidelis) and (2) preoperative venography showed mild collateral flow to the left subclavian vein, a single-coil lead (Sprint Quattro) was also implanted. However, the single-coil defibrillation system was unable to terminate the induced VF with a 25-joule shock, and a maximum shock of 35 joules was required to resume sinus rhythm. Therefore, dual defibrillation shock pathways were created using the additional connection of the superior vena cava coil of the Fidelis lead to the ICD. As a result, induced VF was terminated successfully by 15∼25 joules, and the shock impedance was decreased from 63 to 39 ohms. Using a combined connection between two implanted leads and an ICD generator is uncommon, but it can help some patients, as in our case.

    DOI： 10.4020/jhrs.27.PJ2_070

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  • 致死的不整脈の予知

    池主 雅臣, 相澤 義房

    心臓   43 ( 10 )   1297 - 1302   2011

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    DOI： 10.11281/shinzo.43.1297

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  • Fetal Atrioventricular Block and Postpartum Augmentative QT Prolongation in a Patient With Long-QT Syndrome With KCNQ1 Mutation Reviewed

    Hiroshi Furushima, Masaomi Chinushi, Akinori Sato, Yoshifusa Aizawa, Akira Kikuchi, Koichi Takakuwa, Kenichi Tanaka

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   21 ( 10 )   1170 - 1173   2010.10

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    DOI： 10.1111/j.1540-8167.2010.01758.x

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  • Role of mineralocorticoid receptor-Rac1 axis on atrial structural remodeling and inducibility of atrial fibrillation in hypertensive rats Reviewed

    M. Ito, S. Kimura, M. Tomita, M. Chinushi, M. Kodama, Y. Aizawa

    EUROPEAN HEART JOURNAL   31   1018 - 1018   2010.9

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  • Ventricular Tachyarrhythmia Associated with Hypertrophic Cardiomyopathy: Incidence, Prognosis, and Relation to Type of Hypertrophy Reviewed

    Hiroshi Furushima, Masaomi Chinushi, Kenichi Iijima, Akiko Sanada, Daisuke Izumi, Yukio Hosaka, Yoshifusa Aizawa

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   21 ( 9 )   991 - 999   2010.9

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    DOI： 10.1111/j.1540-8167.2010.01769.x

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  • Inducibility of atrial fibrillation depends not on inflammation but on atrial structural remodeling in rat experimental autoimmune myocarditis Reviewed

    Makoto Hoyano, Masahiro Ito, Shinpei Kimura, Komei Tanaka, Kazuki Okamura, Satoru Komura, Wataru Mitsuma, Satoru Hirono, Masaomi Chinushi, Makoto Kodama, Yoshifusa Aizawa

    Cardiovascular Pathology   19 ( 5 )   e149 - e157   2010.9

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  • Effects of Bepridil Versus E-4031 on Transmural Ventricular Repolarization and Inducibility of Ventricular Tachyarrhythmias in the Dog Reviewed

    Daisuke Izumi, Masaomi Chinushi, Kenichi Iijima, Shizue Ahara, Satoru Komura, Hiroshi Furushima, Yukio Hosaka, Akiko Sanada, Nobue Yagihara, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   33 ( 8 )   950 - 959   2010.8

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  • Efficacy of Procainamide and Lidocaine in Terminating Sustained Monomorphic Ventricular Tachycardia - Retrospective Case Series Reviewed

    Satoru Komura, Masaomi Chinushi, Hiroshi Furushima, Yukio Hosaka, Daisuke Izumi, Kenichi Iijima, Hiroshi Watanabe, Nobue Yagihara, Yoshifusa Aizawa

    CIRCULATION JOURNAL   74 ( 5 )   864 - 869   2010.5

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  • Effect of Bepridil in Atrial Fibrillation Inducibility Facilitated by Vagal Nerve Stimulation - Prevention of Vagal Nerve Activation-Induced Shortening of the Atrial Action Potential Duration Reviewed

    Kenichi Iijima, Masaomi Chinushi, Daisuke Izumi, Shizue Ahara, Hiroshi Furushima, Satoru Komura, Yukio Hosaka, Akiko Sanada, Akinori Sato, Yoshifusa Aizawa

    CIRCULATION JOURNAL   74 ( 5 )   895 - 902   2010.5

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  • Efficacy of Procainamide and Lidocaine in Terminating Sustained Monomorphic Ventricular Tachycardia - Retrospective Case Series Reviewed

    Satoru Komura, Masaomi Chinushi, Hiroshi Furushima, Yukio Hosaka, Daisuke Izumi, Kenichi Iijima, Hiroshi Watanabe, Nobue Yagihara, Yoshifusa Aizawa

    CIRCULATION JOURNAL   74 ( 5 )   864 - 869   2010.5

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  • HIGH FREQUENCY OF ELECTROCARDIOGRAPHIC ABNORMALITIES AT EARLY REPOLARIZATION PHASE IN IDIOPATHIC VENTRICULAR FIBRILLATION Reviewed

    Yuka Hayashi, Hiroshi Watanabe, Kazuki Okamura, Masahito Sato, Yukio Hosaka, Hiroshi Furushima, Masaomi Chinushi, Hirotaka Oda, Masaaki Okabe, Yoshifusa Aizawa

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   55 ( 10 )   2010.3

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  • Delayed Pericardial Effusion Due to Perforation of the Right Ventricular Outflow Tract by an ICD Lead Reviewed

    Masaomi Chinushi, Yukio Hosaka, Shinsuke Okada, Kenichi Iijima, Hiroshi Furushima, Yoshifusa Aizawa

    INTERNAL MEDICINE   49 ( 5 )   389 - 392   2010

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    DOI： 10.2169/internalmedicine.49.2936

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  • Ischemia-Induced Prominent J Waves in a Patient with Brugada Syndrome Reviewed

    Nobue Yagihara, Akinori Sato, Hiroshi Furushima, Masaomi Chinushi, Takashi Hirono, Yoshifusa Aizawa

    INTERNAL MEDICINE   49 ( 18 )   1979 - 1982   2010

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  • Coronary vasospasm triggered ventricular fibrillation delayed after radiofrequency ablation of the right accessory pathway Reviewed

    Yukio Hosaka, Masaomi Chinushi, Kazuyoshi Takahashi, Kazuyuki Ozaki, Takao Yanagawa, Tsutomu Miida, Hirotaka Oda, Yoshifusa Aizawa

    EUROPACE   11 ( 11 )   1554 - 1556   2009.11

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  • Significance of Early Onset and Progressive Increase of Activation Delay During Premature Stimulation in Brugada Syndrome Reviewed

    Hiroshi Furushima, Masaomi Chinushi, Kenichi Iijima, Daisuke Izumi, Yukio Hosaka, Yoshifusa Aizawa

    CIRCULATION JOURNAL   73 ( 8 )   1408 - 1415   2009.8

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    DOI： 10.1253/circj.CJ-08-1111

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  • Effects of verapamil on anterior ST segment and ventricular fibrillation cycle length in patients with Brugada syndrome Reviewed

    Masaomi Chinushi, Kenichi Iijima, Minoru Tagawa, Satoru Komura, Hiroshi Furushima, Yoshifusa Aizawa

    JOURNAL OF ELECTROCARDIOLOGY   42 ( 4 )   367 - 373   2009.7

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  • Pilsicainide-Induced ST Segment Elevation and ST Segment Depression in Two Patients with Variant Forms of Brugada-Type Electrocardiographic Abnormalities Reviewed

    Masaomi Chinushi, Minoru Tagawa, Daisuke Izumi, Hiroshi Furushima, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   32 ( 6 )   811 - 815   2009.6

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  • Focal atrial tachycardia refractory to radiofrequency catheter ablation originating from right atrial appendage Reviewed

    Hiroshi Furushima, Masaomi Chinushi, Yukio Hosaka, Yoshifusa Aizawa

    EUROPACE   11 ( 4 )   521 - 522   2009.4

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  • Metabolic Syndrome and Catheter Ablation in Atrial Fibrillation Reviewed

    Masaomi Chinushi, Masahiro Ito

    CIRCULATION JOURNAL   73 ( 3 )   428 - 429   2009.3

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  • Ventricular Fibrillation Triggered during and after Radiofrequency Energy Delivery to the Site of Origin of Idiopathic Right Ventricular Outflow Tract Arrhythmia Reviewed

    Kenichi Iijima, Masaomi Chinushi, Hiroshi Furushima, Yukio Hosaka, Daisuke Izumi, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   32 ( 3 )   406 - 409   2009.3

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  • Evaluation of channel function after alteration of amino acid residues at the pore center of KCNQ1 channel Reviewed

    Taruna Ikrar, Haruo Hanawa, Hiroshi Watanabe, Yoshiyasu Aizawa, Mahmoud M. Ramadan, Masaomi Chinushi, Minoru Horie, Yoshifusa Aizawa

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   378 ( 3 )   589 - 594   2009.1

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  • Correlation between Surface and Intracardiac Electrocardiogram in a Patient with Inappropriate Defibrillation Shocks Due to Hyperkalemia Reviewed

    Yukio Hosaka, Masaomi Chinushi, Kenichi Iijima, Akiko Sanada, Hiroshi Furushima, Yoshifusa Aizawa

    INTERNAL MEDICINE   48 ( 13 )   1153 - 1156   2009

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  • Segmental Conduction Block in a Low-Voltage Area Suppressed Macro-Reentrant Ventricular Tachycardia after Surgical Repair of Tetralogy of Fallot Reviewed

    Masaomi Chinushi, Satoru Komura, Hiroshi Furushima, Yoshifusa Aizawa

    INTERNAL MEDICINE   48 ( 12 )   1021 - 1023   2009

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    DOI： 10.2169/internalmedicine.48.2048

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  • Comparative Effects of Olmesartan and Azelnidipine on Atrial Structural Remodeling in Spontaneously Hypertensive Rats Reviewed

    Kazuki Okamura, Masahiro Ito, Komei Tanaka, Masaomi Chinushi, Takeshi Adachi, Wataru Mitsuma, Satoru Hirono, Mikio Nakazawa, Makoto Kodama, Yoshifusa Aizawa

    PHARMACOLOGY   83 ( 6 )   360 - 366   2009

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  • Preservation of Renal Function in Response to Cardiac Resynchronization Therapy Reviewed

    Shinpei Kimura, Masahiro Ito, Masaomi Chinushi, Komei Tanaka, Yasutaka Tanabe, Yukio Hosaka, Satoru Komura, Shinsuke Okada, Kenichi Iijima, Hiroshi Furushima, Koichi Fuse, Masahito Sato, Yoshifusa Aizawa

    CIRCULATION JOURNAL   72 ( 11 )   1794 - 1799   2008.11

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    DOI： 10.1253/circj.CJ-08-0424

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  • Ventricular repolarization gradients in a patient with takotsubo cardiomyopathy Reviewed

    Hiroshi Furushima, Masaomi Chinushi, Akiko Sanada, Yoshifusa Aizawa

    EUROPACE   10 ( 9 )   1112 - 1115   2008.9

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    DOI： 10.1093/europace/eun166

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  • Automatic R-wave and impedance testing with the modern patient alert system to reduce inappropriate implantable cardioverter defibrillator shocks due to lead fracture Reviewed

    Masaomi Chinushi, Yukio Hosaka, Noboru Ikarashi, Kenichi Iijima, Hiroshi Furushima, Yoshifusa Aizawa

    EUROPACE   10 ( 6 )   738 - 740   2008.6

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    DOI： 10.1093/europace/eun095

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  • A double-point mutation in the selectivity filter site of the KCNQ1 potassium channel results in a severe phenotype, LQT1, of long QT syndrome Reviewed

    Taruna Ikrar, Haruo Hanawa, Hiroshi Watanabe, Shinsuke Okada, Yoshiyasu Aizawa, Mahmoud M. Ramadan, Satoru Komura, Fumio Yamashita, Masaomi Chinushi, Yoshifusa Aizawa

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   19 ( 5 )   541 - 549   2008.5

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    DOI： 10.1111/j.1540-8167.2007.01076.x

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  • A post-QRS potential in Brugada syndrome its relation to electrocardiographic pattern and possible genesis Reviewed

    Yoshifusa Aizawa, Masaomi Chinushi, Minoru Tagawa, Hiroshi Furushima, Shinsuke Okada, Kenichi Iijima, Daisuke Izumi, Hiroshi Watanabe, Satoru Komura

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   51 ( 17 )   1720 - 1721   2008.4

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  • KCNQ1の複合ヘテロ接合体変異はQT延長症候群と関連する(A Compound Heterozygous Mutation in KCNQ1 Associated with Long QT Syndrome)

    Sato Akinori, Arimura Takuro, Aizawa Yoshiyasu, Ushinohama Hiroya, Ishikawa Shiro, Chinushi Masaomi, Aizawa Yoshifusa, Kimura Akinori

    Circulation Journal   72 ( Suppl.I )   561 - 561   2008.3

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  • Antiarrhythmic vs. pro-arrhythmic effects depending on the intensity of adrenergic stimulation in a canine anthopleurin-A model of type-3 long QT syndrome Reviewed

    Masaomi Chinushi, Daisuke Izumi, Kenichi Iijima, Shizue Ahara, Satoru Komura, Hiroshi Furushima, Yukio Hosaka, Yoshifusa Aizawa

    EUROPACE   10 ( 2 )   249 - 255   2008.2

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    DOI： 10.1093/europace/eun002

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  • Clinical characteristics, treatment; and outcome of tachycardia induced cardiomyopathy Reviewed

    Hiroshi Watanabe, Kazuki Okamura, Masaorni Chinushi, Hiroshi Furushima, Yasutaka Tanabe, Makoto Kodama, Yoshifusa Aizawa

    INTERNATIONAL HEART JOURNAL   49 ( 1 )   39 - 47   2008.1

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  • Comparison of conduction delay in the right ventricular outflow tract between Brugada syndrome and right ventricular cardiomyopathy: investigation of signal average ECG in the precordial leads Reviewed

    Hiroshi Furushima, Masaomi Chinushi, Kazuki Okamura, Kenichi Iijima, Satoru Komura, Yasutaka Tanabe, Shinsuke Okada, Daisuke Izumi, Yoshifusa Aizawa

    EUROPACE   9 ( 10 )   951 - 956   2007.10

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  • Effect of dl-sotalol on mortality and recurrence of ventricular Tachyarrhythmias: Ischemic compared to nonischemic cardiomyopathy Reviewed

    Hiroshi Furushima, Masaomi Chinushi, Kazuki Okamura, Satoru Komura, Yasutaka Tanabe, Akinori Sato, Daisuke Izumi, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   30 ( 9 )   1136 - 1141   2007.9

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  • Evaluating patients with acute ischemic stroke with special reference to newly developed atrial fibrillation in cerebral embolism Reviewed

    Minoru Tagawa, Shigekazu Takeuchi, Masaomi Chinushi, Makihiko Saeki, Yoshinori Taniguchi, Yuichi Nakamura, Hideko Ohno, Keiko Kitazawa, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   30 ( 9 )   1121 - 1128   2007.9

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  • Incidence and initial characteristics of pilsicainide-induced ventricular arrhythmias in patients with Brugada syndrome Reviewed

    Masaomi Chinushi, Satoru Komura, Daisuke Izumi, Hiroshi Furushima, Yasutaka Tanabe, Takashi Washizuka, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   30 ( 5 )   662 - 671   2007.5

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    DOI： 10.1111/j.1540-8159.2007.00728.x

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  • Human cardiac ryanodine receptor mutations in ion channel disorders in Japan Reviewed

    Yoshiyasu Aizawa, Wataru Mitsuma, Taruna Ikrar, Satoru Komura, Haruo Hanawa, Seiichi Miyajima, Fumito Miyoshi, Youichi Kobayashi, Masaomi Chinushi, Akinori Kimura, Masayasu Hiraoka, Yoshifusa Aizawa

    INTERNATIONAL JOURNAL OF CARDIOLOGY   116 ( 2 )   263 - 265   2007.3

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  • Therapeutic effects of bepridil on ventricular tachyarrhythmias

    CHINUSHI Masaomi, IZUMI Daisuke, FURUSHIMA Hiroshi, AIZAWA Yoshifusa

    Japanese Journal of Electrocardiology   27 ( 1 )   53 - 60   2007.1

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  • Non-pharmacological management of ventricular tachycardia Reviewed

    Masaomi Chinushi, Yoshifusa Aizawa

    Circulation Journal   71   A-97 - A-105   2007

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  • Bepridil for drug-refractory ventricular tachyarrhythmias Reviewed

    Daisuke Izumi, Masaomi Chinushi, Hiroshi Watanabe, Takashi Washizuka, Kazuki Okamura, Satoru Komura, Yasutaka Tanabe, Hiroshi Furushima, Yoshifusa Aizawa

    INTERNAL MEDICINE   46 ( 3 )   119 - 124   2007

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  • Multiple premature beats triggered ventricular arrhythmias during pilsicainide infusion in a patient with inferior ST-segment elevation Reviewed

    Masaomi Chinushi, Daisuke Izumi, Hiroshi Furushima, Hiroshi Watanabe, Yoshifusa Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   29 ( 12 )   1445 - 1448   2006.12

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    DOI： 10.1111/j.1540-8159.2006.00562.x

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  • Angiotensin 2 type 1 receptor blocker attenuates atrial structural remodeling in spontaneously hypertensive rats: Role of the suppression of atrial oxidative stress Reviewed

    Kazuki Okamura, Masahiro Ito, Masaomi Chinushi, Makoto Kodama, Yoshifusa Aizawa

    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   41 ( 6 )   1053 - 1054   2006.12

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  • Transient left ventricular apical ballooning developing after the Central Niigata Prefecture Earthquake: two case reports. Reviewed

    Tagawa M, Nakamura Y, Ishiguro M, Satoh K, Chinushi M, Kodama M, Aizawa Y

    Journal of cardiology   48 ( 3 )   153 - 158   2006.9

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  • Role of autonomic nervous activity in the antiarrhythmic effects of magnesium sulfate in a canine model of polymorphic ventricular Tachyarrhythmia associated with prolonged QT interval Reviewed

    Masaomi Chinushi, Daisuke Izumi, Satoru Komura, Shizue Ahara, Akinori Satoh, Hiroshi Furushima, Takashi Washizuka, Yoshifusa Aizawa

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   48 ( 3 )   121 - 127   2006.9

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  • Amiodarone therapy in patients implanted with cardioverter-defibrillator for life-threatening ventricular arrhythmias Reviewed

    Kazuhiro Satomi, Takashi Kurita, Seiji Takatsuki, Yasuhiro Yokoyama, Masaomi Chinushi, Naoya Tsuboi, Takashi Nitta, Morio Shoda, Hideo Mitamura

    CIRCULATION JOURNAL   70 ( 8 )   977 - 984   2006.8

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  • Shortening of the ventricular fibrillatory intervals after administration of verapamil in a patient with Brugada syndrome and vasospastic angina Reviewed

    M Chinushi, M Tagawa, Y Nakamura, Y Aizawa

    JOURNAL OF ELECTROCARDIOLOGY   39 ( 3 )   331 - 335   2006.7

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  • Over-expression of Kv1.5 in rat cardiomyocytes extremely shortens the duration of the action potential and causes rapid excitation Reviewed

    Yasutaka Tanabe, Katsuharu Hatada, Naoki Naito, Yoshiyasu Aizawa, Masaomi Chinushi, Hiroyuki Nawa, Yoshifusa Aizawa

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   345 ( 3 )   1116 - 1121   2006.7

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  • Decrease in amplitude of intracardiac ventricular electrogram and inappropriate therapy in patients with an implantable cardioverter defibrillator Reviewed

    Hiroshi Watanabe, Masaomi Chinushi, Daisuke Izumi, Akinori Sato, Shinsuke Okada, Kazuki Okamura, Satoru Komura, Yukio Hosaka, Hiroshi Furushima, Takashi Washizuka, Yoshifusa Aizawa

    INTERNATIONAL HEART JOURNAL   47 ( 3 )   363 - 370   2006.5

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  • Distinct U wave changes in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) Reviewed

    Yoshiyasu Aizawa, Satoru Komura, Shinsuke Okada, Masaomi Chinushi, Yoshifusa Aizawa, Hiroshi Morita, Tohru Ohe

    INTERNATIONAL HEART JOURNAL   47 ( 3 )   381 - 389   2006.5

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  • Comparison of efficacy of sotalol and nifekalant for ventricular tachyarrhythmias Reviewed

    H Watanabe, M Chinushi, T Washizuka, H Sugiura, T Hirono, Y Aizawa, S Komura, Y Hosaka, Y Tanabe, H Furushima, Y Aizawa

    CIRCULATION JOURNAL   70 ( 5 )   583 - 587   2006.5

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  • Tumor necrosis factor-alpha inhibits the cardiac delayed rectifier K current via the asphingomyelin pathway Reviewed

    K Hatada, T Washizuka, M Horie, H Watanabe, F Yamashita, M Chinushi, Y Aizawa

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   344 ( 1 )   189 - 193   2006.5

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    DOI： 10.1016/j.bbrc.2006.03.115

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  • Ventricular tachycardia late after repair of congenital heart disease: efficacy of combination therapy with radiofrequency catheter ablation and class III antiarrhythmic agents and long-term outcome Reviewed

    H Furushima, M Chinushi, H Sugiura, S Komura, Y Tanabe, H Watanabe, T Washizuka, Y Aizawa

    JOURNAL OF ELECTROCARDIOLOGY   39 ( 2 )   219 - 224   2006.4

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  • Japanese randomized trial for investigation of a combined therapy of amiodarone and implantable cardioverter defibrillator in patients with ventricular tachycardia and fibrillation - The Nippon ICD plus Pharmacologic Option Necessity (NIPPON) study design Reviewed

    T Kurita, H Mitamura, Y Aizawa, T Nitta, K Aonuma, N Tsuboi, M Chinushi, Y Kobayashis, K Soejima, K Satomi, H Furushima, T Ohe, S Ogawa, Kodama, I, H Ohtsu, T Yamazaki

    CIRCULATION JOURNAL   70 ( 3 )   316 - 320   2006.3

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  • Japanese randomized trial for investigation of a combined therapy of amiodarone and implantable cardioverter defibrillator in patients with ventricular tachycardia and fibrillation - The Nippon ICD plus Pharmacologic Option Necessity (NIPPON) study design Reviewed

    T Kurita, H Mitamura, Y Aizawa, T Nitta, K Aonuma, N Tsuboi, M Chinushi, Y Kobayashis, K Soejima, K Satomi, H Furushima, T Ohe, S Ogawa, Kodama, I, H Ohtsu, T Yamazaki

    CIRCULATION JOURNAL   70 ( 3 )   316 - 320   2006.3

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  • Elimination of late potentials by quinidine in a patient with Brugada syndrome Reviewed

    H Watanabe, M Chinushi, A Osaki, K Okamura, D Izumi, S Komura, Y Hosaka, Y Tanabe, H Furushima, T Washizuka, Y Aizawa

    JOURNAL OF ELECTROCARDIOLOGY   39 ( 1 )   63 - 66   2006.1

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  • Relationship between dominant prolongation of the filtered QRS duration in the right precordial leads and clinical characteristics in Brugada syndrome Reviewed

    H Furushima, M Chinushi, T Hirono, H Sugiura, H Watanabe, S Komura, T Washizuka, Y Aizawa

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   16 ( 12 )   1311 - 1317   2005.12

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    DOI： 10.1111/j.1540-8167.2005.00262.x

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  • Nifekalant hydrochloride suppresses severe electrical storm in patients with malignant ventricular tachyarrhythmias Reviewed

    T Washizuka, M Chinushi, H Watanabe, Y Hosaka, S Komura, H Sugiura, T Hirono, H Furushima, Y Tanabe, Y Aizawa

    CIRCULATION JOURNAL   69 ( 12 )   1508 - 1513   2005.12

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  • Transient giant negative T waves associated with cardiac involvement of diffuse large B-cell lymphoma Reviewed

    M Ito, J Tsuchiyama, M Chinushi, M Kodama, Y Aizawa

    CIRCULATION   112 ( 20 )   E322 - E323   2005.11

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  • Heart rate variability is a useful parameter for evaluation of anticholinergic effect associated with inducibility of atrial fibrillation Reviewed

    H Sugiura, M Chinushi, S Komura, T Hirono, Y Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   28 ( 11 )   1208 - 1214   2005.11

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    DOI： 10.1111/j.1540-8159.2005.40071.x

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  • Similarities between Brugada syndrome and ischemia-induced ST-segment elevation. Clinical correlation and synergy Reviewed

    M Chinushi, H Furushima, Y Tanabe, T Washizuka, Y Aizawaz

    JOURNAL OF ELECTROCARDIOLOGY   38 ( 4 )   18 - 21   2005.10

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    DOI： 10.1016/j.jelectrocard.2005.06.004

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  • Human cardiac ryanodine receptor mutations in ion channel disorders in Japan Reviewed

    Y Aizawa, W Mitsuma, S Komura, K Ueda, M Chinushi, Y Aizawa, M Hiraoka, C Antzelevitch

    CIRCULATION   112 ( 17 )   U150 - U150   2005.10

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  • Inappropriate discharges of intravenous implantable cardioverter defibrillators owing to lead failure Reviewed

    T Washizuka, M Chinushi, R Kazama, T Hirono, H Watanabe, S Komura, H Sugiura, Y Tanabe, H Furushima, S Fujita, Y Okura, Y Aizawa

    INTERNATIONAL HEART JOURNAL   46 ( 5 )   909 - 913   2005.9

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  • Effects of intravenous magnesium in a prolonged QT interval model of polymorphic ventricular tachycardia focus on transmural ventricular repolarization Reviewed

    M Chinushi, H Sugiura, S Komura, T Hirono, D Izumi, M Tagawa, H Furushima, Y Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   28 ( 8 )   844 - 850   2005.8

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  • Impact of earthquakes on Takotsubo cardiomyopathy Reviewed

    H Watanabe, M Kodama, Y Okura, Y Aizawa, N Tanabe, M Chinushi, Y Nakamura, T Nagai, M Sato, M Okabe

    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION   294 ( 3 )   305 - 307   2005.7

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  • Variable electrocardiographic effects of short-term quinidine sulfate administration in Brugada syndrome Reviewed

    H Watanabe, M Chinushi, T Washizuka, H Sugiura, T Hirono, S Komura, Y Hosaka, M Yamaura, Y Tanabe, H Furushima, Y Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   28 ( 5 )   372 - 377   2005.5

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  • Electrophysiologic study-guided therapy with sotalol for life-threatening ventricular tachyarrhythmias Reviewed

    H Watanabe, M Chinushi, T Washizuka, H Sugiura, T Hirono, S Komura, Y Hosaka, Y Tanabe, H Furushima, S Fujita, K Kato, Y Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   28 ( 4 )   285 - 290   2005.4

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  • Unsuccessful internal defibrillation in Brugada syndrome: Focus on refractoriness and ventricular fibrillation cycle length Reviewed

    H Watanabe, M Chinushi, H Sugiura, T Washizuka, S Komura, Y Hosaka, H Furushima, H Watanabe, J Hayashi, Y Aizawa

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   16 ( 3 )   262 - 266   2005.3

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  • A novel mutation in FKBP12.6 binding region of the human cardiac ryanodine receptor gene (R2401H) in a Japanese patient with catecholaminergic polymorphic ventricular tachycardia Reviewed

    Y Aizawa, K Ueda, S Komura, T Washizuka, M Chinushi, N Inagaki, Y Matsumoto, T Hayashi, M Takahashi, N Nakano, M Yasunami, A Kimura, M Hiraoka, Y Aizawa

    INTERNATIONAL JOURNAL OF CARDIOLOGY   99 ( 2 )   343 - 345   2005.3

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  • Genomic and non-genomic regulation of L-type calcium channels in rat ventricle by thyroid hormone Reviewed

    H Watanabe, T Washizuka, S Komura, T Yoshida, Y Hosaka, K Hatada, Y Aizawa, M Chinushi, T Yamamoto

    ENDOCRINE RESEARCH   31 ( 1 )   59 - 70   2005

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  • Potential candidates for cardiac resynchronization therapy in Japanese patients with idiopathic dilated cardiomyopathy - A niigata multicenter study of DCM Reviewed

    S Komura, M Chinushi, M Kudo, T Saikawa, Y Tanabe, H Furushima, T Washizuka, M Kodama, H Oda, S Miyajima, F Masani, Y Igarashi, M Murata, Y Aizawa

    CIRCULATION JOURNAL   68 ( 12 )   1104 - 1109   2004.12

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  • Postprandial variations in ST-segment in a patient with Brugada syndrome and partial gastrectomy Reviewed

    H Watanabe, M Chinushi, K Hao, H Sugiura, T Hirono, S Komura, Y Hosaka, Y Tanabe, H Furushima, S Fujita, T Washizuka, Y Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   27 ( 11 )   1560 - 1562   2004.11

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  • Radiofrequency catheter ablation for incessant atrioventricular nodal reentrant tachycardia normalized H-V block associated with tachycardia-induced cardiomyopathy Reviewed

    H Furushima, M Chinushi, H Sugiura, Y Aizawa

    JOURNAL OF ELECTROCARDIOLOGY   37 ( 4 )   315 - 319   2004.10

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  • Indications for an implantable cardioverter defibrillator (ICD) Reviewed

    Y Aizawa, M Chinushi, T Washizuka

    INTERNAL MEDICINE   43 ( 5 )   360 - 367   2004.5

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  • Ventricular tachyarrhythmia associated with cardiac sarcoidosis: Its mechanisms and outcome Reviewed

    H Furushima, M Chinushi, H Sugiura, H Kasai, T Washizuka, Y Aizawa

    CLINICAL CARDIOLOGY   27 ( 4 )   217 - 222   2004.4

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  • Intramyocardial hemorrhage caused by myocardial contusion Reviewed

    Y Hosaka, M Kodama, M Chinushi, T Washizuka, H Sugiura, K Satou, Y Aizawa

    CIRCULATION   109 ( 2 )   277 - 277   2004.1

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  • Thyroid hormone regulates mRNA expression and currents of ion channels in rat atrium Reviewed

    H Watanabe, ML Ma, T Washizuka, S Komura, T Yoshida, Y Hosaka, K Hatada, M Chinushi, T Yamamoto, K Watanabe, Y Aizawa

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   308 ( 3 )   439 - 444   2003.8

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    DOI： 10.1016/S0006-291X(03)01420-7

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  • Mechanism of discordant T wave alternans in the in vivo heart Reviewed

    M Chinushi, D Kozhevnikov, EB Caref, M Restivo, N El-Sherif

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   14 ( 6 )   632 - 638   2003.6

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  • Function, subcellular localization and assembly of a novel mutation of KCNJ2 in Andersen's syndrome Reviewed

    Y Hosaka, H Hanawa, T Washizuka, M Chinushi, F Yamashita, T Yoshida, S Komura, H Watanabe, Y Aizawa

    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   35 ( 4 )   409 - 415   2003.4

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  • Micro dislodgment of ventricular pacing lead undetectable during rapid pacing one year after implantation Reviewed

    Y Chinushi, M Chinushi, H Furushima, Y Tanabe, T Washizuka, Y Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   26 ( 3 )   787 - 788   2003.3

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    DOI： 10.1046/j.1460-9592.2003.00138.x

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  • Ventricular tachyarrhythmias in a canine model of LQT3 - Arrhythmogenic effects of sympathetic activity and therapeutic effects of mexiletine Reviewed

    M Chinushi, M Tagawa, H Sugiura, S Komura, Y Hosaka, T Washizuka, Y Aizawa

    CIRCULATION JOURNAL   67 ( 3 )   263 - 268   2003.3

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  • Suppression of electrical storm by biventricular pacing in a patient with idiopathic dilated cardiomyopathy and ventricular tachycardia Reviewed

    Y Tanabe, M Chinushi, T Washizuka, S Minagawa, H Furushima, H Watanabe, Y Hosaka, S Komura, Y Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   26 ( 1 )   101 - 102   2003.1

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  • Characteristics of a novel mutation of KCNJ2 in Andersen's syndrome Reviewed

    Y Hosaka, H Hanawa, T Washizuka, M Chinushi, F Yamashita, T Yoshida, A Abe, S Komura, H Watanabe, Y Aizawa

    CIRCULATION   106 ( 19 )   47 - 47   2002.11

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  • Induction of ventricular fibrillation in Brugada syndrome by site-specific right ventricular premature depolarization Reviewed

    M Chinushi, T Washizuka, Y Chinushi, K Higuchi, T Toida, Y Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   25 ( 11 )   1649 - 1651   2002.11

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  • Activation-recovery interval as a parameter to assess the intracardiac ventricular repolarization in patients with congenital long QT syndrome Reviewed

    M Chinushi, T Washizuka, Y Hosaka, H Furushima, Y Tanabe, Y Chinushi, Y Aizawa

    AMERICAN JOURNAL OF CARDIOLOGY   90 ( 4 )   432 - +   2002.8

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    DOI： 10.1016/S0002-9149(02)02506-7

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  • Arrhythmogenesis of T wave alternans associated with surface QRS complex alternans and the role of ventricular prematurity: Observations from a canine model of LQT3 syndrome Reviewed

    M Chinushi, Y Hosaka, T Washizuka, H Furushima, Y Aizawa

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   13 ( 6 )   599 - 604   2002.6

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  • Correlation between the effective refractory period and activation-recovery interval calculated from the intracardiac unipolar electrogram of humans with and without dl-Sotalol treatment - Reply Reviewed

    M Chinushi

    CIRCULATION JOURNAL   66 ( 3 )   308 - 309   2002.3

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  • Class I antiarrhythmic drug and coronary vasospasm-induced T wave alternans and ventricular tachyarrhythmia in a patient with Brugada syndrome and vasospastic angina Reviewed

    Y Chinushi, M Chinushi, T Toida, Y Aizawa

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   13 ( 2 )   191 - 194   2002.2

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  • Effects of Nifekalant on reentrant circuit of sustained ventricular tachycardia

    WASHIZUKA Takashi, CHINUSHI Masaomi, SUGIURA Hirotaka, KOMURA Satoru, WATANABE Hiroshi, HOSAKA Yukio, TANABE Yasutaka, YAMAURA Masayuki, FURUSHIMA Hiroshi, ABE Akira, AIZAWA Yoshifusa

    Journal of controlled release : official journal of the Controlled Release Society   18 ( 1 )   25 - 32   2002.1

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  • [Possibility of gene-specific treatment for hereditary arrhythmic diseases]. Reviewed

    Chinushi M, Washizuka T

    Nihon rinsho. Japanese journal of clinical medicine   60 ( 1 )   143 - 148   2002.1

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  • Inappropriate discharges by fourth generation implantable cardioverter defibrillators in patients with ventricular arrhythmias Reviewed

    T Washizuka, M Chinushi, M Tagawa, H Kasai, H Watanabe, Y Hosaka, F Yamashita, H Furushima, A Abe, H Watanabe, J Hayashi, Y Aizawa

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   65 ( 11 )   927 - 930   2001.11

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  • Absence of morning peak in ventricular tachycardia and fibrillation events in nonischemic heartr disease: analysis of therapies by implantable cardioverter defibrillators. Reviewed

    Keiichi, Tanaka, Yoshihusa, Aizawa, Takashi, Washizuka, Masaomi, Chinushi, Ken, Okumura, Satoshi, Ogawa, Hiroshi, Kasanuki, Keisuke, Kuga, Takashi, Kurita, Shiro, Kamakura, et, al on behalf of, the, Japanese ICD, Study Group

    Pacing and Clinical Electrophysiology   24 ( 11 )   1602 - 1606   2001.11

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  • QT interval prolongation and torsades de pointes unmasked by intracoronary acetylcholine administration Reviewed

    M Chinushi, Nakagawa, I, T Hori, F Yamashita, T Washizuka, Y Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   24 ( 10 )   1561 - 1562   2001.10

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  • Arrythmogenicity of intramural T wave alternans under operation of autonomic activity and its correlation to the results of surface ECG Reviewed

    M Chinushi, H Furushima, T Washizuka, M Tagawa, Y Hosaka

    CIRCULATION   104 ( 17 )   111 - 111   2001.10

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  • Myocardium extending from the left atrium onto the pulmonary veins: A comparison between subjects with and without atrial fibrillation Reviewed

    M Tagawa, K Higuchi, M Chinushi, T Washizuka, T Ushiki, N Ishihara, Y Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   24 ( 10 )   1459 - 1463   2001.10

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    DOI： 10.1046/j.1460-9592.2001.01459.x

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  • Correlation between the effective refractory period and activation-recovery interval calculated from the intracardiac unipolar electrogram of humans with and without dl-sotalol treatment Reviewed

    M Chinushi, M Tagawa, H Kasai, T Washizuka, A Abe, H Furushima, Y Aizawa

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   65 ( 8 )   702 - 706   2001.8

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  • Discrepancy between inducibility of ventricular tachycardia and activity of cardiac sarcoidosis - Requirement of defibrillator implantation for the inactive stage of cardiac sarcoidosis Reviewed

    T Mezaki, M Chinushi, T Washizuka, H Furushima, Y Chinushi, K Ebe, H Okumura, Y Aizawa

    INTERNAL MEDICINE   40 ( 8 )   731 - 735   2001.8

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    DOI： 10.2169/internalmedicine.40.731

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  • Cycle length-associated modulation of the regional dispersion of ventricular repolarization in a canine model of long QT syndrome Reviewed

    M Chinushi, EB Caref, M Restivo, G Noll, Y Aizawa, N El-Sherif

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   24 ( 8 )   1247 - 1257   2001.8

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    DOI： 10.1046/j.1460-9592.2001.01247.x

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  • Inappropriate discharges from an intravenous implantable cardioverter defibrillator due to T-wave oversensing Reviewed

    T Washizuka, M Chinushi, H Kasai, H Watanabe, M Tagawa, Y Hosaka, A Abe, Y Aizawa

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   65 ( 7 )   685 - 687   2001.7

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    DOI： 10.1253/jcj.65.685

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  • Role of alpha 1-blockade in congenital long QT syndrome - Investigation by exercise stress test Reviewed

    H Furushima, M Chinushi, T Washizuka, Y Aizawa

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   65 ( 7 )   654 - 658   2001.7

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    DOI： 10.1253/jcj.65.654

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  • Implantable cardioveter defibrillator treatment in a patient with idiopathic ventricular fibrillation showing mild ST-T variation in V_1-V_3 leads

    HAYASHI Manabu, CHINUSHI Masaomi, FUKUNAGA Hiroshi, HOSAKA Yukio, OKUMURA Hiroshi, KASAI Hidehiro, TAGAWA Minoru, ABE Akira, WASHIZUKA Takashi, AIZAWA Yoshifusa

    Japanese Journal of Electrocardiology   21 ( 3 )   336 - 342   2001.5

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    DOI： 10.5105/jse.21.336

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  • Intravenous administration of class I antiarrhythmic drugs induced T wave alternans in a patient with Brugada syndrome Reviewed

    M Chinushi, T Washizuka, H Okumura, Y Aizawa

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   12 ( 4 )   493 - 495   2001.4

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    DOI： 10.1046/j.1540-8167.2001.00493.x

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  • Mechanism and arrhythmogenicity of discordant QT/T alternans Reviewed

    M Chinushi, DO Kozhevnikov, EB Caref, M Restivo, N El-Sherif

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   37 ( 2 )   91A - 92A   2001.2

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  • Abrupt loss of constant fusion during entrainment of ventricular tachycardia at a critical paced cycle length Reviewed

    M Yamaura, Y Aizawa, M Chinushi, T Washizuka, H Uchiyama, H Kitazawa

    JAPANESE HEART JOURNAL   42 ( 1 )   67 - 78   2001.1

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  • Vasospastic angina accompanied by Brugada-type electrocardiographic abnormalities Reviewed

    M Chinushi, Y Kuroe, E Ito, M Tagawa, Y Aizawa

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   12 ( 1 )   108 - 111   2001.1

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    DOI： 10.1046/j.1540-8167.2001.00108.x

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  • Demonstration of transient entrainment in monomorphic sustained ventricular tachycardia associated with cardiac sarcoidosis Reviewed

    M Chinushi, T Mezaki, Y Aoki, Nakagawa, I, T Washizuka, Y Aizawa

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   64 ( 8 )   635 - 637   2000.8

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  • Antitachycardia burst pacing for pleomorphic reentrant ventricular tachycardias associated with non-coronary artery diseases - A morphology specific programming for ventricular tachycardias Reviewed

    M Chinushi, M Tagawa, H Kasai, A Abe, K Taneda, T Washizuka, Y Aizawa

    JAPANESE HEART JOURNAL   41 ( 3 )   313 - 324   2000.5

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  • Structure of the reentrant circuit of idiopathic left ventricular tachycardia: New insights into the role of the Purkinje network Reviewed

    T Washizuka, M Chinushi, S Niwano, Y Aizawa

    JOURNAL OF ELECTROCARDIOLOGY   33 ( 2 )   195 - 198   2000.4

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    DOI： 10.1016/S0022-0736(00)80076-X

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  • Development of ventricular fibrillations with different characteristics in the local electrocardiogram - Large and small amplitude of activation, and its implication for implantable cardioverter defibrillator treatment Reviewed

    M Chinushi, T Washizuka, H Kasai, K Ohhira, M Satoh, Y Aizawa

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   63 ( 12 )   1007 - 1010   1999.12

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    DOI： 10.1253/jcj.63.1007

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  • Recovery of the right atrial effective refractory period after cardioversion of chronic atrial fibrillation Reviewed

    Y Tanabe, M Chinushi, K Taneda, S Fujita, H Kasai, M Yamaura, S Imai, Y Aizawa

    AMERICAN JOURNAL OF CARDIOLOGY   84 ( 10 )   1261 - +   1999.11

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    DOI： 10.1016/S0002-9149(99)00544-5

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  • Both low and high energy cardioversion induced accelerated ventricular tachycardia in a patient treated with an implantable cardioverter defibrillator Reviewed

    T Washizuka, M Chinushi, K Hatada, H Kasai, K Ohhira, H Furushima, Y Aizawa

    JAPANESE HEART JOURNAL   40 ( 5 )   665 - 669   1999.9

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    DOI： 10.1536/jhj.40.665

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  • Beneficial effect of amiodarone on pacing induced terminability of reentrant ventricular tachycardia Reviewed

    M Chinushi, H Uchiyama, Nakagawa, I, T Washizuka, Y Aizawa

    JAPANESE HEART JOURNAL   40 ( 4 )   471 - 475   1999.7

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    DOI： 10.1536/jhj.40.471

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  • Mechanism of arrhythmogenicity of the short-long cardiac sequence that precedes ventricular tachyarrhythmias in the long QT syndrome Reviewed

    N El-Sherif, EB Caref, M Chinushi, M Restivo

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   33 ( 5 )   1415 - 1423   1999.4

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    DOI： 10.1016/S0735-1097(98)00700-1

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  • Effect of atropine on QT prolongation and torsade de pointes induced by intracoronary acetylcholine in the long QT syndrome Reviewed

    H Furushima, S Niwano, M Chinushi, M Yamaura, K Taneda, T Washizuka, Y Aizawa

    AMERICAN JOURNAL OF CARDIOLOGY   83 ( 5 )   714 - 718   1999.3

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  • Ventricular fibrillation with small amplitude of activation and its implications for implantable cardioverter defibrillator treatment Reviewed

    M Chinushi, H Kasai, M Tagawa, T Washizuka, Y Aizawa

    JAPANESE HEART JOURNAL   40 ( 1 )   87 - 90   1999.1

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    DOI： 10.1536/jhj.40.87

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  • Autonomic nerve activity and long QT interval syndrome - A role of acetylcholine and alpha-adrenoceptor Reviewed

    Y Aizawa, H Furushima, M Chinushi, T Washizuka

    JOURNAL OF ELECTROCARDIOLOGY   32   173 - 176   1999

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    DOI： 10.1016/S0022-0736(99)90076-6

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  • Role of alpha 1-adrenoceptor long QT syndrome Reviewed

    H Furushima, S Niwano, M Chinushi, M Yamaura, T Washizuka, Y Aizawa

    CIRCULATION   98 ( 17 )   776 - 776   1998.10

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  • QT/T alternans and arrhythmias in the long QT syndrome Reviewed

    M Chinushi, EB Caref, M Restivo, N El-Sherif

    CIRCULATION   98 ( 17 )   10 - 10   1998.10

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  • Electrophysiological basis of arrhythmogenicity of QT/T alternans in the long-QT syndrome - Tridimensional analysis of the kinetics of cardiac repolarization Reviewed

    M Chinushi, M Restivo, EB Caref, N El-Sherif

    CIRCULATION RESEARCH   83 ( 6 )   614 - 628   1998.9

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    DOI： 10.1161/01.RES.83.6.614

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  • The use of the block cycle length as a safe and efficient means of interrupting sustained ventricular tachycardia and its pharmacological modification Reviewed

    K Ohira, S Niwano, H Furushima, K Taneda, M Chinushi, Y Aizawa

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   21 ( 9 )   1686 - 1692   1998.9

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  • Successful slow pathway ablation in a patient with atrioventricular nodal reentrant tachycardia having a proximal common pathway Reviewed

    M Chinushi, Y Aizawa, Y Ogawa, S Fujita, Y Kusano, S Miyajima, A Shibata

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   21 ( 6 )   1316 - 1318   1998.6

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    DOI： 10.1111/j.1540-8159.1998.tb00195.x

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  • Repetitive ventricular responses induced by radiofrequency ablation for idiopathic ventricular tachycardia originating from the outflow tract of the right ventricle Reviewed

    M Chinushi, Y Aizawa, K Ohhira, S Fujita, M Shiba, S Niwano, H Furushima

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   21 ( 4 )   669 - 678   1998.4

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    DOI： 10.1111/j.1540-8159.1998.tb00122.x

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  • Bifid T waves induced by isoprenaline in a patient with Brugada syndrome Reviewed

    T Washizuka, M Chinushi, S Niwano, Y Aizawa

    HEART   79 ( 3 )   305 - 307   1998.3

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  • Intracoronary acetylcholine-induced prolongation of monophasic action potential in long QT syndrome Reviewed

    H Furushima, S Niwano, M Chinushi, M Shiba, S Fujita, A Abe, K Ohhira, K Taneda, Y Aizawa

    JAPANESE HEART JOURNAL   39 ( 2 )   225 - 233   1998.3

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  • Relation between bradycardia dependent long QT syndrome and QT prolongation by disopyramide in humans Reviewed

    H Furushima, S Niwano, M Chinushi, K Ohhira, A Abe, Y Aizawa

    HEART   79 ( 1 )   56 - 58   1998.1

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  • Frequency dependent shortening of conduction time through the reentrant pathway during transient entrainment of ventricular tachycardia Reviewed

    Y Aizawa, E Itoh, M Chinushi, M Shiba, H Uchiyama, A Shibata

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   21 ( 1 )   126 - 129   1998.1

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    DOI： 10.1111/j.1540-8159.1998.tb01071.x

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  • Effects of the ATP-sensitive K channel opener nicorandil on the QT interval and the effective refractory period in patients with congenital long QT syndrome Reviewed

    Yoshifusa Aizawa, Hirohide Uchiyama, Masayuki Yamaura, Toshio Nakayama, Makoto Arita, H. Inoue, S. Ogawa, H. Kasanuki, S. Kamakura, M. Chinushi

    Journal of Electrocardiology   31 ( 2 )   117 - 123   1998

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  • Electrophysiological mechanism of the characteristic electrocardiographic morphology of torsade de pointes tachyarrhythmias in the long-QT syndrome - Detailed analysis of ventricular tridimensional activation patterns Reviewed

    N ElSherif, M Chinushi, EB Caref, M Restivo

    CIRCULATION   96 ( 12 )   4392 - 4399   1997.12

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  • Electrophysiologic mechanism of the characteristic electrocardiographic morphology of Torsade de Pointes tachyarrhythmias in the long QT syndrome Reviewed

    N ElSherif, M Chinushi, EB Caref, M Restivo

    CIRCULATION   96 ( 8 )   3103 - 3103   1997.10

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  • Relation of surface QT/T-wave alternans to repolarization in the long QT syndrome (LOTS): Role of left ventricular M-cells Reviewed

    M Chinushi, M Restivo, EB Caref, G Nollo, Stoyanovsky, V, N ElSherif

    CIRCULATION   96 ( 8 )   1815 - 1815   1997.10

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  • Radiofrequency catheter ablation for idiopathic right ventricular tachycardia with special reference to morphological variation and long term outcome Reviewed

    M Chinushi, Y Aizawa, K Takahashi, H Kitazawa, A Shibata

    HEART   78 ( 3 )   255 - 261   1997.9

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  • Clockwise and counter-clockwise circulation of wavefronts around an anatomical obstacle as one mechanism of two morphologies of sustained ventricular tachycardia in patients after a corrective operation of tetralogy of Fallot Reviewed

    M Chinushi, Y Aizawa, H Kitazawa, K Takahashi, T Washizuka, A Shibata

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   20 ( 9 )   2279 - 2281   1997.9

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    DOI： 10.1111/j.1540-8159.1997.tb04250.x

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  • Fusion with postpaced return cycle identical to tachycardia cycle length during transient entrainment of ventricular tachycardia and its implications Reviewed

    H Kitazawa, T Washizuka, H Uchiyama, M Chinushi, S Niwano

    JAPANESE HEART JOURNAL   38 ( 3 )   369 - 378   1997.5

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  • Ventricular tachycardia initiated by high energy cardioversion in a patient with an implantable cardioverter defibrillator Reviewed

    M Chinushi, Y Aizawa, K Higuchi

    HEART   77 ( 4 )   373 - 374   1997.4

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  • Discrepant drug action of disopyramide on ECG abnormalities and induction of ventricular arrhythmias in a patient with Brugada syndrome Reviewed

    M Chinushi, Y Aizawa, Y Ogawa, M Shiba, K Takahashi

    JOURNAL OF ELECTROCARDIOLOGY   30 ( 2 )   133 - 136   1997.4

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    DOI： 10.1016/S0022-0736(97)80021-0

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  • Adaptation of repolarization across the ventricular wall in the long QT Syndrome Reviewed

    EB Caref, M Restivo, M Chinushi, Stoyanovsky, V, S John, M Chaudry, N ElSherif

    BIOPHYSICAL JOURNAL   72 ( 2 )   MP124 - MP124   1997.2

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  • Morphological variation of nonreentrant idiopathic ventricular tachycardia originating from the right ventricular outflow tract and effect of radiofrequency lesion Reviewed

    M Chinushi, Y Aizawa, K Takahashi, O Kouji, H Kitazawa, T Washizuka, A Abe, A Shibata

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   20 ( 2 )   325 - 336   1997.2

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    DOI： 10.1111/j.1540-8159.1997.tb06177.x

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  • Preferential action of mexiletine on central common pathway of reentrant ventricular tachycardia Reviewed

    Y Aizawa, A Abe, K Ohira, H Furushima, M Chinushi, S Fujita

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   28 ( 7 )   1759 - 1764   1996.12

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    DOI： 10.1016/S0735-1097(96)00375-0

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  • Action of antiarrhythmic agents on the area of slow conduction in ventricular tachycardia Reviewed

    Y Aizawa, M Chinushi, A Abe, K Ohhira, M Shiba, S Fujita

    JAPANESE HEART JOURNAL   37 ( 5 )   773 - 784   1996.9

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  • Acetylcholine-induced prolongation of the QT interval in idiopathic long QT syndrome Reviewed

    Y Aizawa, T Washizuka, Y Igarashi, H Kitazawa, M Chinushi, A Abe, A Shibata

    AMERICAN JOURNAL OF CARDIOLOGY   77 ( 10 )   879 - &   1996.4

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  • Suppression of fluid accumulation following pericardial inflammation in a patient with primary chylopericardium Reviewed

    M Chinushi, Y Watanabe, Y Aizawa, H Hanawa, M Yamazoe, Y Osman, A Shibata, M Shinonaga

    JAPANESE HEART JOURNAL   37 ( 2 )   271 - 274   1996.3

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  • Discrepant effects of mexiletine on cycle length of ventricular tachycardia and on the effective refractory period in the area of slow conduction Reviewed

    Y Aizawa, M Chinushi, H Kitazawa, T Washizuka, A Abe, A Shibata, Kodama, I

    HEART   75 ( 3 )   281 - 286   1996.3

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    DOI： 10.1136/hrt.75.3.281

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  • Long-term results of radiofrequency catheter ablation in non-ischemic sustained ventricular tachycardia with underlying heart disease - Nonuniform arrhythmogenic substrate and mode of ablation Reviewed

    M Chinushi, Y Aizawa, K Ohhira, A Abe, A Shibata

    JAPANESE HEART JOURNAL   37 ( 2 )   183 - 194   1996.3

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    DOI： 10.1536/ihj.37.183

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  • Drug-induced narrowing of the width of the zone of entrainment as a predictor of the subsequent non-inducibility of reentrant ventricular tachycardia after an additional dose of an antiarrhythmic drug Reviewed

    Y Aizawa, M Chinushi, N Naitoh, A Shibata

    HEART   75 ( 2 )   165 - 170   1996.2

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  • Limited success of pharmacological therapy and indications for catheter ablation in ventricular tachycardia Reviewed

    Y Aizawa, M Chinushi, T Washizuka, K Takahashi

    RECENT PROGRESS IN ELECTROPHARMACOLOGY OF THE HEART   203 - 211   1996

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  • RADIOFREQUENCY CURRENT CAUSED SLOWING OF NONREENTRANT IDIOPATHIC RIGHT-VENTRICULAR TACHYCARDIA ORIGINATING FROM A WIDE ARRHYTHMOGENIC AREA Reviewed

    M CHINUSHI, Y AIZAWA, A SHIBATA

    BRITISH HEART JOURNAL   74 ( 6 )   698 - 699   1995.12

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  • SUCCESSFUL RADIOFREQUENCY CATHETER ABLATION FOR MACROREENTRANT VENTRICULAR TACHYCARDIAS IN A PATIENT WITH TETRALOGY OF FALLOT AFTER CORRECTIVE SURGERY Reviewed

    M CHINUSHI, Y AIZAWA, H KITAZAWA, Y KUSANO, T WASHIZUKA, A SHIBATA

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   18 ( 9 )   1713 - 1716   1995.9

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  • CATHETER ABLATION OF VENTRICULAR-TACHYCARDIA WITH RADIOFREQUENCY CURRENTS, WITH SPECIAL REFERENCE TO THE TERMINATION AND MINOR MORPHOLOGIC CHANGE OF REINDUCED VENTRICULAR-TACHYCARDIA Reviewed

    Y AIZAWA, M CHINUSHI, N NAITOH, H KITAZAWA, T WASHIZUKA, H UCHIYAMA, A SHIBATA

    AMERICAN JOURNAL OF CARDIOLOGY   76 ( 8 )   574 - 579   1995.9

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    DOI： 10.1016/S0002-9149(99)80158-1

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  • SPATIAL ORIENTATION AT THE REENTRANT CIRCUIT AT IDIOPATHIC LEFT-VENTRICULAR TACHYCARDIA Reviewed

    Y AIZAWA, M CHINUSHI, H KITAZAWA, T WASHIZUKA, K TAKAHASHI, M SHIBA, K OHHIRA, A ABE, A SHIBATA

    AMERICAN JOURNAL OF CARDIOLOGY   76 ( 4 )   316 - 319   1995.8

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    DOI： 10.1016/S0002-9149(99)80092-7

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  • SPATIAL ORIENTATION AT THE REENTRANT CIRCUIT AT IDIOPATHIC LEFT-VENTRICULAR TACHYCARDIA Reviewed

    Y AIZAWA, M CHINUSHI, H KITAZAWA, T WASHIZUKA, K TAKAHASHI, M SHIBA, K OHHIRA, A ABE, A SHIBATA

    AMERICAN JOURNAL OF CARDIOLOGY   76 ( 4 )   316 - 319   1995.8

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  • NICORANDIL SUPPRESSES A HUMP ON THE MONOPHASIC ACTION-POTENTIAL AND TORSADE-DE-POINTES IN A PATIENT WITH IDIOPATHIC LONG QT SYNDROME Reviewed

    M CHINUSHI, Y AIZAWA, H FURUSHIMA, H INUZUKA, K OJIMA, A SHIBATA

    JAPANESE HEART JOURNAL   36 ( 4 )   477 - 481   1995.7

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  • ALTERNATION OF QRS MORPHOLOGY AND EFFECT OF RADIOFREQUENCY ABLATION IN IDIOPATHIC VENTRICULAR-TACHYCARDIA Reviewed

    T WASHIZUKA, Y AIZAWA, M CHINUSHI, N NAITOH, T MIYAJIMA, Y KUSANO, H KITAZAWA, H UCHIYAMA, K TAKAHASHI, A SHIBATA, S MIYAJIMA, M SATOU

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   18 ( 1 )   18 - 27   1995.1

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    DOI： 10.1111/j.1540-8159.1995.tb02471.x

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  • Radiofrequency current caused slowing of nonreentrant idiopathic right ventricular tachycardia originating from a wide arrhythmogenic area Reviewed

    Masaomi Chinushi, Yoshifusa Aizawa, Akira Shibata

    Heart   74 ( 6 )   698 - 699   1995

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    DOI： 10.1136/hrt.74.6.698

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  • Administration of combination therapy with class Ic and class II antiarrhythmic drugs for a patient with WPW syndrome

    M. Chinushi, H. Yamaguchi, K. Tanabe, H. Furushima, Y. Ogawa, H. Inuzuka, K. Ojima, Y. Kusano, Y. Aizawa, A. Shibata

    Respiration and Circulation   43 ( 3 )   283 - 287   1995

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  • RADIOFREQUENCY CURRENT CATHETER ABLATION FOR VENTRICULAR-TACHYCARDIA Reviewed

    M CHINUSHI, Y AIZAWA, Y KUSANO, T WASHIZUKA, T MIYAJIMA, N NAITHO, K TAKAHASHI, A SHIBATA

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   58 ( 5 )   315 - 325   1994.5

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  • CONDUCTIVE PROPERTY OF THE ZONE OF SLOW CONDUCTION OF REENTRANT VENTRICULAR-TACHYCARDIA AND ITS RELATION TO PACING-INDUCED TERMINABILITY Reviewed

    M AIZAWA, Y AIZAWA, M CHINUSHI, K TAKAHASHI, A SHIBATA

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   17 ( 1 )   46 - 55   1994.1

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  • EVIDENCE FOR SLOW CONDUCTION AREAS DURING PACING IN PATIENTS WITH SINUS RHYTHM, AND THEIR RELATION TO THE SITE OF VT ORIGIN Reviewed

    M CHINUSHI, Y AIZAWA, Y KUSANO, T WASHIZUKA, A SHIBATA

    JAPANESE HEART JOURNAL   35 ( 1 )   1 - 13   1994.1

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  • Critical cycle length of rapid pacing to interrupt ventricular tachycardia depends on sodium channel availability within the reentry circuit

    Y. Kusano, Y. Aizawa, M. Chinushi, T. Miyajima, A. Shibata, I. Kodama

    Japanese Heart Journal   35 ( 1 )   415 - 416   1994

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  • Radiofrequency catheter ablation for ventricular tachycardia

    M. Chinushi, Y. Aizawa, Y. Kusano, H. Kitazawa, A. Shibata

    Japanese Heart Journal   35 ( 1 )   291 - 292   1994

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  • IDIOPATHIC VENTRICULAR-FIBRILLATION AND BRADYCARDIA-DEPENDENT INTRAVENTRICULAR BLOCK Reviewed

    Y AIZAWA, M TAMURA, M CHINUSHI, N NAITOH, H UCHIYAMA, Y KUSANO, H HOSONO, A SHIBATA

    AMERICAN HEART JOURNAL   126 ( 6 )   1473 - 1474   1993.12

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  • CATHETER ABLATION WITH RADIOFREQUENCY CURRENT OF VENTRICULAR-TACHYCARDIA ORIGINATING FROM THE RIGHT VENTRICLE Reviewed

    Y AIZAWA, M CHINUSHI, N NAITOH, Y KUSANO, H KITAZAWA, K TAKAHASHI, H UCHIYAMA, A SHIBATA

    AMERICAN HEART JOURNAL   125 ( 5 )   1269 - 1275   1993.5

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  • PLEOMORPHIC VENTRICULAR-TACHYCARDIA ARISING FROM A NEW SITE DURING ANTIARRHYTHMIC DRUG-THERAPY Reviewed

    M CHINUSHI, Y AIZAWA, N NAITOH, H KITAZAWA, Y KUSANO, M TAMURA, A SHIBATA

    JAPANESE HEART JOURNAL   34 ( 3 )   255 - 268   1993.5

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  • ALTERNATION IN THE FUSION COMPLEX DURING CONSTANT PACING OF SUSTAINED VENTRICULAR-TACHYCARDIA Reviewed

    M CHINUSHI, Y AIZAWA, Y KUSANO, H KITAZAWA, T MIYAJIMA, A SHIBATA

    JAPANESE HEART JOURNAL   34 ( 2 )   227 - 234   1993.3

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    DOI： 10.1536/ihj.34.227

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  • CATHETER ABLATION FOR VENTRICULAR TACHYCARDIA - FROM DC TO RF ABLATION Reviewed

    Y AIZAWA, M CHINUSHI, N NAITOH, Y KUSANO, A SHIBATA

    CARDIAC PACING AND ELECTROPHYSIOLOGY TODAY   363 - 365   1993

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  • SUCCESSFUL RADIOFREQUENCY CURRENT CATHETER ABLATION OF SUSTAINED VENTRICULAR-TACHYCARDIA Reviewed

    M CHINUSHI, Y AIZAWA, H KUWANO, H HOSONO, H KITAZAWA, Y KUSANO, N NAITHO, M TAMURA, A SHIBATA

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   15 ( 10 )   1460 - 1466   1992.10

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  • POSSIBLE INTRAMURAL SITE OF REENTRANT CIRCUIT IN VENTRICULAR-TACHYCARDIA OF NONISCHEMIC CAUSE - PREOPERATIVE AND INTRAOPERATIVE MAPPING STUDIES Reviewed

    M CHINUSHI, Y AIZAWA, F MASANI, A OBATA, A SHIBATA

    JAPANESE HEART JOURNAL   33 ( 4 )   505 - 512   1992.7

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  • FREQUENCY AND OUTPUT-DEPENDENT CHANGE IN CONDUCTION OVER SLOW PATHWAYS IN A PATIENT WITH SUSTAINED VENTRICULAR-TACHYCARDIA UNRELATED TO CORONARY-ARTERY DISEASE Reviewed

    M CHINUSHI, Y AIZAWA, T FUNAZAKI, M TAMURA, A SHIBATA

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   15 ( 5 )   756 - 761   1992.5

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  • INCIDENCE AND MECHANISM OF INTERRUPTION OF REENTRANT VENTRICULAR-TACHYCARDIA WITH RAPID VENTRICULAR PACING Reviewed

    Y AIZAWA, S NIWANO, M CHINUSHI, M TAMURA, Y KUSANO, T MIYAJIMA, H KITAZAWA, A SHIBATA

    CIRCULATION   85 ( 2 )   589 - 595   1992.2

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  • AN ATTEMPT AT ELECTRICAL CATHETER ABLATION OF THE ARRHYTHMOGENIC AREA IN IDIOPATHIC VENTRICULAR-FIBRILLATION Reviewed

    Y AIZAWA, M TAMURA, M CHINUSHI, S NIWANO, Y KUSANO, N NAITOH, A SHIBATA, T TOHJOH, Y UEDA, K JOHO

    AMERICAN HEART JOURNAL   123 ( 1 )   257 - 260   1992.1

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  • ACTIONS OF ANTIARRHYTHMIC DRUG ON THE REENTRANT CIRCUIT OF SUSTAINED VENTRICULAR-TACHYCARDIA Reviewed

    Y AIZAWA, M CHINUSHI

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   56   1470 - 1473   1992

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    DOI： 10.1253/jcj.56.SupplementV_1470

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  • LOW-ENERGY CATHETER ELECTRICAL ABLATION FOR SUSTAINED VENTRICULAR-TACHYCARDIA Reviewed

    S NIWANO, Y AIZAWA, M SATOH, M CHINUSHI, A SHIBATA

    AMERICAN HEART JOURNAL   122 ( 1 )   81 - 88   1991.7

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  • AORTITIS SYNDROME, CORONARY-ARTERY ECTASIA, AND MID-VENTRICULAR OBSTRUCTION Reviewed

    M CHINUSHI, M YAMAZOE, Y TAMURA, T FUNAZAKI, Y IGARASHI, T MATSUBARA, Y TANABE, A SHIBATA

    JAPANESE HEART JOURNAL   32 ( 2 )   281 - 286   1991.3

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    DOI： 10.1536/ihj.32.281

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  • PROARRHYTHMIC EFFECTS OF ANTIARRHYTHMIC DRUGS ASSESSED BY ELECTROPHYSIOLOGIC STUDY IN RECURRENT SUSTAINED VENTRICULAR-TACHYCARDIA Reviewed

    M CHINUSHI, Y AIZAWA, S MIYAJIMA, T FUNAZAKI, M TAMURA, A SHIBATA

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   55 ( 2 )   133 - 141   1991.2

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    DOI： 10.1253/jcj.55.133

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  • Abnormal local ventricular electrogram and its relation to induction of ventricular tachycardia in patients with hypertrophic cardiomyopathy Reviewed

    S. Miyajima, Y. Aizawa, M. Satoh, K. Suzuki, T. Funazaki, K. Ebe, S. Niwano, M. Tamura, M. Chinushi, A. Shibata

    Journal of Cardiology   20 ( 3 )   649 - 656   1991

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  • CLINICAL CHARACTERISTICS AND POSSIBLE ROLE OF CORONARY-ARTERY SPASM IN SYNCOPE AND OR ABORTED SUDDEN-DEATH Reviewed

    Y IGARASHI, M YAMAZOE, Y TAMURA, T MATSUBARA, Y TANABE, M CHINUSHI, T YAMAGUCHI, M SAEKI, Y AIZAWA, A SHIBATA

    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION   54 ( 12 )   1477 - 1485   1990.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1253/jcj.54.12_1477

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  • THE OCCURRENCE OF LEUKEMIA IN A PATIENT WITH PULMONARY ASBESTOSIS Reviewed

    M CHINUSHI, S KOYAMA, M TAKAHASHI, A SHIBATA, EMURA, I

    JAPANESE JOURNAL OF MEDICINE   29 ( 6 )   607 - 610   1990.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2169/internalmedicine1962.29.607

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  • Association of sustained ventricular tachycardia and a mid-systolic click: A case report Reviewed

    K. Suzuki, Y. Aizawa, M. Tamura, T. Funazaki, S. Miyajima, S. Niwano, M. Chinushi, M. Sato, K. Ebe, A. Shibata

    Journal of Cardiology   19 ( 21 )   119 - 127   1989

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

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  • AV NODAL REENTRANT TACHYCARDIA WITH A BYSTANDER MAHAIM FIBER Reviewed

    Y AIZAWA, K SUZUKI, M CHINUSHI, A SHIBATA

    JAPANESE HEART JOURNAL   29 ( 6 )   891 - 896   1988.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1536/ihj.29.891

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Books

  • 日本臨床領域別症候群シリーズ 心室内伝導障害，心室内変行伝導

    池主雅臣, 齋藤修（ Role： Contributor）

    日本臨床社  2019.11 

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  • 日本臨床領域別症候群シリーズ 2 束ブロック，3 束ブロック

    池主雅臣, 齋藤修（ Role： Contributor）

    日本臨床社  2019.11 

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  • EPS概論改訂第２版 陳旧性心筋梗塞の持続性心室頻拍・心室細動

    池主雅臣, 保坂幸男（ Role： Contributor）

    南江堂  2019.3 

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  • 循環器内科専門医バイブル。不整脈（識る・診る・治す）

    池主雅臣, 齋藤修, 保坂幸男（ Role： Contributor）

    中山書店  2018.2 

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  • ICD・CRTの考えかた、使い方

    池主 雅臣（ Role： Contributor）

    中外医学社  2018.2 

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  • 不整脈を科学する

    池主 雅臣（ Role： Contributor）

    医歯薬出版  2017.1 

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  • 心室頻拍のすべて

    池主 雅臣（ Role： Contributor）

    南江堂  2016.11 

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  • 超・EPS・入門

    池主 雅臣（ Role： Contributor）

    南江堂  2016.6 

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  • 不整脈診療。クリニカルクエスチョン200

    池主 雅臣（ Role： Contributor）

    診断と治療社  2015.4 

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MISC

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Presentations

  • Symposium: Autonomic Tone and Cardiac Arrhythmias: Insight Into Therapeutic Approach. Arrhythmogenic potential of the renal autonomic nerves activity: Role of electrical nerve stimulation and renal artery ablation.

    Masaomi Chinushi

    日本不整脈心電学会  2021.7 

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  • Impedance monitoring for predicting steam-pop: an experimental study of bipolar radiofrequency ablation using a dual-bath preparation

    齋藤 修, 及川 綾花, 菅井 綾里, 池主 雅臣

    第 85 回日本循環器学会学術集会  2021.3 

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  • Steam-pop induced central or surface myocardial disruption during bipolar radiofrequency catheter ablation

    齋藤 修, 及川 綾花, 菅井 綾里, 池主 雅臣

    第 85 回日本循環器学会学術集会  2021.3 

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  • 高周波をエネルギー源とした深部心筋焼灼法・外来抗凝固薬処方

    池主雅臣

    日本不整脈心電学会関東甲信越地方会  2021.1 

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  • 臨床治療を模倣した高周波アブレーション

    及川綾花, 齋藤修, 菅井綾里, 池主雅臣

    第 84回日本循環器学会学術集会  2020.8 

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  • Lesion characteristics created by short- and nominal-time of RF application

    Osamu Saitoh, Ayaka Oikawa, Ayari Sugai, Shinsuke Okada, Akiko Sanada, Hirotaka Sugiura, Hiroshi Furushima, Masaomi Chinushi

    第 84 回日本循環器学会学術集会  2020.8 

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  • Therapeutic effects of bepridil and verapamil for premature ventricular complexes induced during the enhancement of cardio-sympathetic nerve activity

    齋藤修, 及川綾花, 菅井綾里, 渡辺順也, 古嶋博司, 池主雅臣

    第 84 回日本循環器学会学術集会  2020.7 

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  • Autonomic Nerve Activity and Ventricular Arrhythmia.

    Masaomi Chinushi, Osamu Saitoh, Ayari Sugai

    APHRS 2019 (アジア太平洋Heart Rhythm学会)  2019.10 

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  • Balanced and unbalanced augmentation of sympathetic nerve activity and its correlation to specific ECG features in cardiovascular diseases.

    Ayari Sugai, Osamu Saitoh, Ayaka Oikawa, Junya Watanabe, Hiroshi Furushima, Masaomi Chinushi

    APHRS 2019 (アジア太平洋Heart Rhythm学会)  2019.10 

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  • 臨床心電図を学ぶ

    池主雅臣

    日臨技認定心電検査技師育成研修会  2019.9 

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  • メディカルプロフェッショナルのための「ワクワクする不整脈ヒストリア

    池主雅臣

    第66回日本不整脈心電図学会  2019.7 

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  • Efficacy of anti-tachycardia pacing for very fast ventricular arrhythmias from sub-analysis of NIPPON-storm study

    池主雅臣, 古嶋博司, 齋藤修, 野田崇, 新田隆, 相澤義房, 大江透, 栗田隆志

    第83 回日本循環器学会学術集会  2019.3 

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  • Ventricular arrhythmias developed in association with enhanced cardio-sympathetic activity;

    Ayari Sugai, Osamu Saitoh, Junya Watanabe, Ayaka Oikawa, Masaomi Chinushi

    APHRS2018 (アジア太平洋heart Rhythm学会)  2018.10 

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  • Characteristics of the therapy-resistant ventricular arrhythmias developed in hypothermic condition

    齋藤修, 渡辺順也, 菅井綾里, 古嶋博司, 池主雅臣

    第82 回日本循環器学会学術集会  2018.3 

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  • Cooling temperature-dependent change in myocardial conduction and repolarization; Biphasic effects on ventricular arrhythmias

    渡辺順也, 齋藤修, 菅井綾里, 古嶋博司, 池主雅臣

    第82 回日本循環器学会学術集会  2018.3 

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  • Renal sympathetic nerve as a therapeutic target for ventricular arrhythmia

    Masaomi Chinushi, Osamu Saitoh, Junya Watanabe, Ayari Sugai, Hiroshi Furushima

    82 回日本循環器学会学術集会  2018.3 

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  • 低温負荷による不整脈基盤の誘導（低体温療法模倣モデルを用いた検討）

    渡辺順也, 齋藤修, 菅井綾里, 鈴木克弥, 藤原直士, 古嶋博司, 池主雅臣

    第81 回日本循環器学会学術集会  2017.3 

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Research Projects

  • 貫通性焼灼を安全に完遂する多角的モニタリング法と出力調整長時間通電法の構築

    Grant number：23K07502

    2023.4 - 2026.3

    System name：科学研究費助成事業

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    齋藤 修, 池主 雅臣

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    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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  • 深部心筋に安定焼灼傷を形成する高周波通電法構築（抵抗伝導加熱と灌流冷却の適正化）

    Grant number：22K08096

    2022.4 - 2025.3

    System name：科学研究費助成事業

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    池主 雅臣, 齋藤 修

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    冠動脈灌流によって拍動収縮する食用豚心筋切片モデルを用いて、心筋興奮指標（局所電位、興奮閾値、興奮伝搬）・工学電気指標（電流・電圧・インピーダンス）をモニターして高周波通電ができるオリジナル実験系で、深部心筋に安定した焼灼傷を形成する通電法の構築を進めている。2022年は通電中のインピーダンス変化に応じて高周波出力を調整するインピーダンスガイドパワーコントロール（IGPC）法を考案し、その有効性と安全性を検証した。IGPC法は通電中のインピーダンスの過剰低下を予防することができ、従来の固定出力法に比べて心筋貫壁性焼灼傷を安全に形成することができた。実験ではIGPC法が同一仕事量の固定出力法に比して、貫壁性焼灼傷の形成成功率が高く、スチームポップによる合併症も回避できる事が検証された。またその理由はIGPC法が伝導加熱を有効利用しているためと考えられた。これらの成果は専門誌と関連学会に報告した。
    高周波アブレーション治療後の不整脈再発は不十分な心筋加熱にある。心筋は一定時間50℃以上に加熱されると安定した焼灼傷に至るが、不十分加熱の場合は一時的に抑制された興奮伝導が術後に回復して不整脈の再発に至る。高周波アブレーションに用いられるイリゲーションカテーテルは、カテーテル接触心筋の過度な温度上昇を防ぐため、生理食塩水噴射でカテーテル先端を冷却しながら通電を行う。イリゲーションカテーテルでは通電開始初期の最大温度上昇点は心筋表面よりやや深部となる。このため不十分出力で短時間通電を行った場合、治療直後に抑制された心筋表面の興奮伝導が再伝導を生じる事を実験的に検証した。またこの再発現象は通電時間を適正化する事で予防できることを確認して関連学会で報告した。

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  • Radiofrequency ablation of ventricular arrhythmias arising from deep myocardium (coronary perfused beating hearts in the dual-bath experimental setting)

    Grant number：19K08512

    2019.4 - 2022.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    Chinushi Masaomi

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    Using an experimental model of porcine myocardium that beat and contract with coronary perfusion, we constructed an experimental system in which radiofrequency ablation can be performed while monitoring myocardial excitation (local potential, excitation threshold and electrocardiogram), delivering electrical parameters (current, voltage, and impedance), and ultrasound imaging information.
    The following approaches were considered effective in improving ablation efficiency; (1) use of the Bipolar ablation method, and (2) appropriately long application time for maximizing the conduction heating effect. Short-time application using irrigation catheter may restore the excitation of superficial myocardium. Important items to ensure safety were as follows; (1) avoid high power energy delivered by Bipolar ablation method for thin myocardial areas to prevent steam-pop, and (2) limit total impedance drop during ablation within 20-25 ohm

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  • Electrophysiological characteristics of ventricular arrhythmias developed in hypothermic conditions.

    Grant number：19K08574

    2019.4 - 2022.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    Saitoh Osamu

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    This study was performed to clarify hypothermia arrhythmias' electrophysiological and excitatory characteristics using the porcine heart model.
    The main findings of this study were as follows; suppressed automaticity, slowed conduction, prolonged repolarization, more heterogeneous distribution of repolarization, higher pacing stimulus threshold and reduced cardiac contraction were observed as myocardial temperature decreased (37, 32, 28℃). In addition, ventricular arrhythmias were most frequently induced at 28 ℃ by programmed electrical stimulation. Ventricular fibrillation in advanced hypothermia was accompanied by an increased defibrillation threshold and decreased dominant frequency and power.
    These results seemed to be characterized as therapy-resistant ventricular arrhythmias in the advanced hypothermic condition.

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  • Biological treatment using cytosolic migration type drug delivery (Validation in myocardial infarction model)

    Grant number：17K08947

    2017.4 - 2020.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    Okuda Akiko

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    Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

    Experimental techniques for introducing proteins into cells are still immature and should be to developed for future therapies and diagnostics. We have developed a cytosolic transition type membrane-penetrating peptide (Pas2r12) in which a hydrophobic sequence is added to cell membrane-penetrating peptide (r12). It was found that Pas2r12 introduces antibodies and green fluorescent protein into cytosol via caveolae mediated endocytosis.

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  • Establishment of safe and effective indices of bipolar radiofrequency ablation for the treatment of intractable arrhythmias

    Grant number：16K09424

    2016.4 - 2019.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    Saitoh Osamu

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

    This study was performed to identify safe and effective use of bipolar radiofrequency (RF) ablation in clinical treatment. The main findings are (1) results of our dual-bath experimental model suggested that RF lesions in human hearts seemed to be larger than that expected from the findings from conventional single-bath experimental models, (2) steam-pop phenomenon was accompanied with a greater impedance decrease as compared to that in absence of steam-pop, (3) lesion depth was well correlated with the integral value of time-dependent decreases in impedance, and (4) as compared to delivering high energy-for a short duration, a longer application time with moderate energy seems to be much safer to create a reasonable lesion depth without steam-pop phenomenon.

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  • The establishment of the predictor for lethal ischemia-related arrhythmia and the elucidation of pathological mechanism and new treatment by identification of responsible genes.

    Grant number：23591031

    2011.4 - 2015.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    SATO Akinori, CHINUSHI Masaomi

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    Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

    The ischemic heart disease such as the myocardial infarction would be lethal. In fact, the majority of those deaths would happen suddenly, resulting from the ischemia-induced cardiac arrhythmia. We studied the electrocardiographic findings, J wave, as a predictor for lethal arrhythmia. We showed the frequency of a J wave in general population. And we reviewed frequencies and morphologies of J wave in patients with and without ischemic ventricular fibrillation during induction of coronary spasm. As a result, we reported that the presense of J wave and the dynamic changes of J wave contributed to ischemic ventricular fibrillation, and that the J wave can be the predictive factor for occurrences of ischemic ventricular fibrillation. Also, we accumulated clinical features and genetic information of over 70 cases that had suffered from ischemic ventricular fibrillation, and presented analysis results including a treatment method for ischemia-induced arrhythmia at academic meetings.

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  • Evaluation of spacial heterogeneous distribution of ventricular repolarization and arrhythmic risk by the body surface standard electrocardiogram

    Grant number：23591032

    2011 - 2013

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    IZUMI Daisuke, CHINUSHI Masaomi, FURUSHIMA Hiroshi

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    Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）

    Fatal ventricular tachyarrhythmias often originate from enlargement of ventricular transmural dispersion of repolarization (TDR). Using canine model which showed spacial heterogeneous distribution of ventricular repolarization, we studied the relationship between the interval of the peak-to-end of the T wave (Tp-e) in ECG and the 3-dimensional repolarization heterogeneity. Tp-e in the limb leads expresses total distribution of repolarization in the left ventricle (LV). The proportion of variance of TDR in each LV region for Tp-e on V2-4 were higher in the anterior rather than in the lateral region, while those on V5-6 were higher in the lateral or midventricular/apical region rather than in the anterior or basal region. The precordial Tp-e seemed to express a certain degree of TDR at near and vertical ventricular wall. These results elucidated the electrophysiological background of the T wave and showed the alternative method of the discrimination of the fatal arrhythmic risk.

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  • Arrhythmogenic substrate and therapeutic interventions of Tdp induced by class III and IV antiarrhythmic drugs(Tridimentional mapping of the heart)

    Grant number：21590890

    2009 - 2011

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    CHINUSHI Masaomi, FURUSHIMA Hiroshi

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

    A high correlation was found between surface ECG Tp-e(from peak to end interval of T wave) and total left ventricular dispersion. In contrast, pseudo transmural Tp-e correlated with transmural recovery time(RT) dispersion. The shortest RT in the heart roughly corresponded to the peak, as did the longest RT with the end of the T wave on the surface ECG. Pacing treatment was most effective in anthopleurin-A model followed by E-4031, bepridil and amiodarone model. On the other hand, supplemental treatment of potassium showed the greatest therapeutic effect in E-4031 model. Magnesium homogenized the distribution of ventricular repolarization in anthopleurin-A model but not in the other models created by E-4031, bepridil and amiodarone.

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  • Investigation of conduction abnormality in right ventricular outflow tract in Brugada syndrome.

    Grant number：21590889

    2009 - 2011

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    FURUSHIMA Hiroshi, CHINUSHI Masaomi

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    Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）

    Patients with Brugada syndrome had greater circadian variation in signal averaged ECG in contrast to patients with arrhythmogenic right ventricular cardiomyopathy, whose late potential may caused by the conduction delay due to fibro fatty replacement in the right ventricle. Late potential in Brugada syndrome might be caused by different mechanism from scar-related late potential.
    Conduction delay during premature stimulation, especially in the outflow tract of the right ventricle, might suggest electrophysiological arrhythmogenic substrate in Brugada syndrome.

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  • Three-dimensional mapping of an arrhythmogenic substrate of ventricular fibrillation modulated by autonomic nerve activity

    Grant number：17590713

    2005 - 2006

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    CHINUSHI Masaomi, FURUSHIMA Hiroshi, TANABE Yasutaka

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    Grant amount：\3400000 （ Direct Cost: \3400000 ）

    In our experimental models of ventricular arrhythmia (VA), unipolar electrograms through the ventricular wall were recorded using multipolar plunge needle electrodes. Local ventricular repolarization was estimated by analyzing the activation-recovery interval (ARI) from the electrograms. Autonomic nerve activity was modulated by electrical stimulation of the stellate ganglions and cervical vagosympathetic trunks or intravenous administration of epinephrine. Spectrum analysis was performed using the data from body surface ECG.
    In the control state, intravenous administration of epinephrine or electrical stimulation of the stellate ganglions induced ventricular premature beats (PVCs) and/or non-sustained VA. In the model of E4031, these PVCs triggered VF. On the other hand, in the model of bepridil, the numbers of PVCs were decreased and VF was seldom induced by the augmentation of sympathetic nerve activity. In an anthopleurin-A (AP-A.) model of the prolonged QT interval, low output of sympathetic nerve stimulation or a low dose of epinephrine by intravenous administration abbreviated the QT interval and homogenized ventricular repolarization in the heart without induction of sustained VA. However, high output of sympathetic nerve stimulation or a larger dose of epinephrine injection provoked VF.
    The therapeutic effect of magnesium sulfate (Mg^<++>) for VA and the role played by the autonomic nervous system in the effects of Mg^<++> were studied in an AP-A model. Intravenous administration of Mg^<++> rapidly eliminated self-terminating polymorphic VA and all isolated PVCs. Mg^<++> caused a modest shortening of ARI at all recording sites although this effect was transient. Since the magnitude of ARI shortening was greater at mid-myocardial sites than at other ventricular sites, mean transmural ARI dispersion decreased after Mg^<++> injection. Similar effects of Mg^<++>- were observed after drug-induced autonomic block. Besides suppression of triggered premature activity, homogenization of transmural ventricular repolarization was associated with the antiarrhythmic effects of intravenous Mg^<++>. The antiarrhythmic effects of Mg^<++> in this model were attributable to its direct pharmacological properties, and not to changes in ambient autonomic nervous activity.
    Disopyramide and bepridil attenuated the effect of vagal stimulation in the atrial myocardium, and this was associated with the therapeutic effects for the vagal stimulation induced atrial fibrillation. Heart rate variability is a useful parameter for evaluation of the effect of anti-arrhythmic drugs on the autonomic nerve system.

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  • Trafficking abnormality in genetic arrhythmias and its modulation.

    Grant number：16590664

    2004 - 2005

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    AIZAWA Yoshifusa, HANAWA Haruo, CHINUSHI Masaomi, YAMASHITA Fumio

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    Grant amount：\3100000 （ Direct Cost: \3100000 ）

    1. Screening of Genes of myocardial channels and functional assay.
    In congenital long QT syndrome, we found abnormal genes coding potassium channel (mainly LQT1) and 5 were de novo. Of these, the amino-acid at the filter site of the pore was found abnormal and loss of function was confirmed. The structure of the membrane domain of LQT1 by a computer showed precisely the abnormal site. New abnormal genes were also found in catecholaminergic polymorphic ventricular tachycardia and reported as the first case from Japan. Totally negative results for gene abnormalities were found in Brugada syndrome, so far.
    2. Modulation of trafficking defect.
    The C terminal is essential for trafficking of LQT1 and found two cases showing trafficking defect. One is with a case with T578M mutation but the prediction of structural change of the C-terminal of LQT1 by computer analysis was failed. To modulate the trafficking defect, RNA was attempted but mRNA with a single mutation was not suppressed. This led to the re-study of RNAi in mRNA with co-expressed with wild type. Over-expression of K-channel by transfection was possible but, so far, it provided a model of arrhythmia.

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  • Role of Sympathetic Nerve Activity for Modulation of Transmural Ventricular Repolarization and Initiation of Ventricular Fibrillation

    Grant number：15590729

    2003 - 2004

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    CHINUSHI Masaomi, WASHIZUKA Takashi, FURUSHIMA Hiroshi, TANABE Yasutaka

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    Grant amount：\3500000 （ Direct Cost: \3500000 ）

    Unipolar electrograms through the ventricular wall (endocardial layer, mid-myocardial layer : Mid, and epicardial layer : Epi) were recorded using multipolar plunge needle electrodes. Local ventricular repolarization was estimated by analyzing the activation-recovery interval(ARI) from the electrograms. Autonomic nerve activity was altered using electrical stimulation of both sides of stellate ganglions and cervical vagosympathetic trunks of canine experimental models of ventricular tachyarrhythmia(VTA). To evaluate the autonomic nerve activity, spectrum analysis (Mem Calc method) was performed using the data from body surface ECG.
    Electrical stimulation of the left stellate ganglion induced non-sustained VTA in the control state. After administration of E4031,VTA occasionally degenerated into ventricular fibrillation(VF) whereas sotalol prevented induction of VTA. In an anthopleurin-A(AP-A) model of a prolonged QT interval, low output of sympathetic stimulation abbreviated QT interval and homogenized the ventricular repolarization in the heart, but high output stimulation provoked VF.
    Sympathetic nerve activity gradually increased after cassation of vagal stimulation, and T wave alternans(TWA), and sometimes, VF were induced in an AP-A model. TWA created a large spatial dispersion of the ventricular repolarization in the heart, and initiation of VF was associated with a delayed condition and/or functional conduction block at the Mid layer. Different electrophysiological characteristics between the Mid and Epi layers ; ARI restitution kinetics (larger ΔARI and τ at Mid) and diastolic intervals, contributed to initiate concordant TWA. Furthermore, discordant TWA which created a much larger spatial dispersion of ventricular repolarization developed between the Mid and Epi layers when QT interval shortening occurred in two successive beats at the Mid or Epi layers. Mexiletine shortened baseline QT interval in an AP-A model and prevented initiation of TWA and VF associated with sympathetic nerve activity. Intracardiac autonomic nerve activity was reasonably represented on the parameters of spectrum analysis of body surface ECG.

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  • QT延長症候群の心電図変動と致死性不整脈の発症機序に関する心室興奮の三次元的検討

    Grant number：11770350

    1999 - 2000

    System name：科学研究費助成事業 奨励研究(A)

    Research category：奨励研究(A)

    Awarding organization：日本学術振興会

    池主 雅臣

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    Grant amount：\1800000 （ Direct Cost: \1800000 ）

    本研究課題では、ビーグル犬のQT延長症候群モデル(LQTS)を用いて、心室内の興奮伝搬と不応期の分布を三次元的にマッピングして以下の結果を得た。
    (1)独自の針電極で心室を貫壁性にマッピングすると、LQT2モデル・LQT3モデルいずれにおいても心筋中層(Mcell領域)の不応期が心内膜側と心外膜側よりも長く、貫壁性に不応期の不均一分布が認められた。
    (2)Tdpが発症する心臓の不応期分布の不均一性には部位特異性があり、左室・心室中隔に比して右室では不均一性が小さく、このためTdpに関与する伝導ブロックの出現も稀であった。この部位特異性にはM細胞の分布とrestitution kineticsの相違が関与した。
    (3)心内のT波交代現象の不整脈源性は、貫壁性の不応期分布の不均一性亢進と伝導ブロックの形成によった。T波交代現象の程度が大きくなると、心室貫壁性の再分極勾配は1拍づつ逆転した。しかしこのような心内の再分極の変化は体表面心電図には必ずしも反映されず、体表面心電図は心内の不整脈源性を過小評価している可能性が示唆された。
    (4)顕著なQT/T交代現象で心内に伝導ブロックが生じると、期外収縮がなくともTdpが頻発した。この場合体表面心電図のQRS波形と体血圧にも変化が観察された。
    (5)QT/T交代現象はメキシレチンによって消失・抑制されたが、これは心内不応期が短縮する作用と関係した。一方、ニコランジル・ベラパミルのQT/T交代現象に対する効果は軽度であった。
    (6)今後は致死的不整脈が生じる心臓での不整脈源性の亢進を、標準体表面心電図でどのように、またどの程度記録できるのかを他の不整脈モデル(心筋梗塞モデル・心不全モデル等)と合わせて検討する必要がある。

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Teaching Experience (researchmap)

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Teaching Experience

  • 日本酒学概論III(医歯学・保健学)

    2026
    Institution name：新潟大学

  • 臨床検査実習II

    2025
    Institution name：新潟大学

  • 臨床検査実習I

    2025
    Institution name：新潟大学

  • 疾病の成因と治療

    2023
    Institution name：新潟大学

  • 日本酒学概論V(医歯学・保健学)

    2023
    Institution name：新潟大学

  • 医療英語ベーシック(検査)

    2022
    -
    2023
    Institution name：新潟大学

  • 病態生理機能学実習

    2021
    Institution name：新潟大学

  • 保健学特定研究(検査技術科学)

    2021
    Institution name：新潟大学

  • 保健学特別研究(検査技術科学)

    2021
    Institution name：新潟大学

  • 生体システム機能検査科学特講演習

    2020
    Institution name：新潟大学

  • 呼吸機能検査科学

    2020
    Institution name：新潟大学

  • 生体システム機能検査科学特講

    2020
    Institution name：新潟大学

  • 医療英語ベーシック(検査)

    2020
    -
    2023
    Institution name：新潟大学

  • リサーチ・メソッズ・ベーシック

    2020
    Institution name：新潟大学

  • 医療安全管理学

    2018
    Institution name：新潟大学

  • フィジカルアセスメント

    2015
    Institution name：新潟大学

  • 臨床薬理学

    2015
    Institution name：新潟大学

  • 病態生理学

    2015
    Institution name：新潟大学

  • 入門医療英語

    2015
    -
    2018
    Institution name：新潟大学

  • 情報科学概論演習

    2014
    Institution name：新潟大学

  • 医用工学概論

    2014
    Institution name：新潟大学

  • 医用工学実習

    2014
    Institution name：新潟大学

  • 生体機能学実習

    2014
    Institution name：新潟大学

  • 医学検査管理総論

    2014
    Institution name：新潟大学

  • 人体機能構造学Ⅱ

    2014
    Institution name：新潟大学

  • 臨床検査実習

    2014
    -
    2024
    Institution name：新潟大学

  • 保健学特別研究(検査技術科学)

    2014
    -
    2019
    Institution name：新潟大学

  • 保健学特定研究(検査技術科学)

    2014
    -
    2016
    Institution name：新潟大学

  • 人体の構造と機能Ⅰ

    2014
    Institution name：新潟大学

  • 疾患と臨床検査

    2011
    -
    2014
    Institution name：新潟大学

  • 病態論

    2010
    Institution name：新潟大学

  • 治療法概説

    2010
    Institution name：新潟大学

  • 疾病の成因と治療Ⅰ

    2010
    -
    2023
    Institution name：新潟大学

  • 臨床生体情報検査科学特別研究

    2010
    -
    2013
    Institution name：新潟大学

  • 人体の構造と機能Ⅱ

    2009
    Institution name：新潟大学

  • 疾病の予防と治療

    2009
    -
    2014
    Institution name：新潟大学

  • 医用写真技術実習

    2009
    Institution name：新潟大学

  • スタディスキルズ (検査)

    2008
    Institution name：新潟大学

  • 病気の成り立ちⅠ

    2008
    -
    2014
    Institution name：新潟大学

  • 生活習慣と健康

    2008
    -
    2014
    Institution name：新潟大学

  • 疾患と臨床検査Ⅰ

    2008
    -
    2010
    Institution name：新潟大学

  • 疾患と臨床検査Ⅱ

    2008
    -
    2010
    Institution name：新潟大学

  • 医療英語(検査)

    2007
    Institution name：新潟大学

  • 病態解析学概論

    2007
    Institution name：新潟大学

  • 病態生理機能学特論

    2007
    Institution name：新潟大学

  • 生理機能検査科学実習

    2007
    Institution name：新潟大学

  • 循環器機能検査科学

    2007
    Institution name：新潟大学

  • 卒業研究

    2007
    -
    2024
    Institution name：新潟大学

  • 病態生理機能学実習

    2007
    -
    2018
    Institution name：新潟大学

  • 生体システム機能検査学特講

    2007
    -
    2016
    Institution name：新潟大学

  • 生体システム機能検査学特講演習

    2007
    -
    2014
    Institution name：新潟大学

  • 画像検査科学

    2007
    -
    2014
    Institution name：新潟大学

  • 筋電図検査科学

    2007
    -
    2013
    Institution name：新潟大学

  • 疾患と臨床検査I

    2007
    Institution name：新潟大学

  • 疾患と臨床検査II

    2007
    Institution name：新潟大学

  • 病気の成り立ちI

    2007
    Institution name：新潟大学

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