Updated on 2024/06/18

写真a

 
WATANABE Masaki
 
Organization
Brain Research Institute Center for Integrated Human Brain Science Assistant Professor
Title
Assistant Professor
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Degree

  • 工学 ( 2011.3   新潟大学 )

Research Interests

  • MRI

  • 脳機能解析

Research Areas

  • Life Science / Biomedical engineering

Research History (researchmap)

  • Niigata University   Brain Research Institute   Assistant Professor

    2002.6

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Research History

  • Niigata University   Brain Research Institute   Assistant Professor

    2002.6

Professional Memberships

 

Papers

  • Corticobasal syndrome mimicking Foix-Chavany-Marie syndrome with suggested 4-repeat tauopathy by tau PET. International journal

    Kosei Nakamura, Yasuko Kuroha, Masahiro Hatakeyama, Atsushi Michael Kimura, Yukimi Nakamura, Yoshihiro Murakami, Masaki Watanabe, Hironaka Igarashi, Tetsuya Takahashi, Hitoshi Shimada

    BMC geriatrics   23 ( 1 )   838 - 838   2023.12

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    BACKGROUND: Corticobasal syndrome (CBS) is a neurodegenerative disease diagnosed based on clinical manifestations such as asymmetrical parkinsonism, limb apraxia, and speech and language impairment. The background pathology of CBS is commonly a variety of proteinopathies, but association with cerebrovascular disease has also been reported. Foix-Chavany-Marie syndrome (FCMS) is a rare neurological disorder characterized by facio-pharyngo-glossal diplegia with automatic-voluntary movement dissociation presenting with bilateral paresis of the facial, lingual, pharyngeal and masticatory muscles. FCMS is commonly attributable to stroke. Transactive response DNA binding protein of 43 kD (TDP-43) proteinopathy is also known as the pathological background of FCMS, while the pathological background of the majority of CBS cases consists of diverse tauopathies instead of TDP-43 proteinopathy. In this report, we describe a case mimicking FCMS that was finally diagnosed as CBS with suggested 4-repeat tauopathy. CASE PRESENTATION: A 68-year-old female started experiencing difficulty speaking followed by difficulty writing, and especially texting, several years before her visit. Her impairment had been gradually worsening, and she came to our hospital. On neurological examination, she demonstrated the facial apraxia, frontal lobe dysfunction, and upper motor neuron signs. She presented some characteristics suggestive of FCMS. Her symptoms exhibited rapid progression and myoclonus, parkinsonism, and left-side dominant cortical sensory deficit occurred, resulting in the fulfillment of diagnostic criteria for CBS after 9 months. Tau PET imaging displayed notable ligand uptake in the brainstem, subthalamic nuclei, basal ganglia, and bilateral subcortical frontal lobe, suggesting that her pathological background was 4-repeat tauopathy. As a result of her progressive dysphagia, she became unable to eat and passed away after 12 months. CONCLUSION: We hereby present an atypical case of CBS showing clinical features mimicking FCMS at first presentation. TDP-43 proteinopathy was suspected based on the clinical symptoms in the early stages of the disease; however, the clinical course and imaging findings including tau PET suggested that her pathological background was 4-repeat tauopathy.

    DOI: 10.1186/s12877-023-04564-z

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  • Changes in functional connectivity among vestibulo-visuo-somatosensory and spatial cognitive cortical areas in persistent postural-perceptual dizziness: resting-state fMRI studies before and after visual stimulation

    Chihiro Yagi, Yuka Morita, Tatsuya Yamagishi, Shinsuke Ohshima, Shuji Izumi, Kuniyuki Takahashi, Masaki Watanabe, Kosuke Itoh, Yuji Suzuki, Hironaka Igarashi, Arata Horii

    Frontiers in Neurology   14   2023.7

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    Publishing type:Research paper (scientific journal)   Publisher:Frontiers Media SA  

    Introduction

    Persistent postural-perceptual dizziness (PPPD) is a functional chronic vestibular syndrome with symptom exacerbation by upright posture, motion, and complex visual stimuli. Among these exacerbating factors, visual exacerbation is the most specific characteristic of PPPD requiring further investigation. We hypothesized that stimulus-induced changes occur in the functional connectivity (FC) rather than simple neural activation that is involved in visual stimulation. The present study aimed to identify the neural basis of PPPD by investigating FC before and after visual stimulation.

    Methods

    Eleven patients with PPPD and 11 age- and sex-matched healthy controls (HCs) underwent resting-state fMRI (rs-fMRI) before and after task-based fMRI with visual stimuli.

    Results

    At pre-stimulus, FC between the vestibular cortex and visual areas was low, while that between the somatosensory and visual areas was high in PPPD compared with that in HCs. FC between the visuospatial (parahippocampal gyrus) and spatial cognitive areas (inferior parietal lobule) was elevated in PPPD even in the pre-stimulus condition, which no longer increased at post-stimulus as observed in HCs. In the post-stimulus condition, FC between the visual and spatial cognitive areas and that between the visual and prefrontal areas increased compared with that in the pre-stimulus condition in PPPD. Task-based fMRI demonstrated that no brain regions showed different activities between the HC and PPPD groups during visual stimulation.

    Discussion

    In PPPD, vestibular inputs may not be fully utilized in the vestibulo-visuo-somatosensory network. Given that the FC between visuospatial and spatial cognitive areas increased even in HCs after visual stimuli, elevated status of this FC in combination with the high FC between the somatosensory and visual areas would be involved in the visual exacerbation in PPPD. An increase in FC from the visual areas to spatial cognitive and prefrontal areas after visual stimuli may account for the prolonged symptoms after visual exacerbation and anxious status in PPPD.

    DOI: 10.3389/fneur.2023.1215004

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  • Model-free cluster analysis for multi-b-value diffusion-weighted imaging of the inferior alveolar nerve Reviewed

    Makoto Terumitsu, Akiko Otsuka, Hitoshi Matsuzawa, Masaki Watanabe, Kenji Seo

    Journal of Oral and Maxillofacial Radiology   11 ( 1 )   16 - 16   2023

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    Publishing type:Research paper (scientific journal)   Publisher:Medknow  

    DOI: 10.4103/jomr.jomr_2_23

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  • SWI by 7T MR Imaging for the Microscopic Imaging Diagnosis of Astrocytic and Oligodendroglial Tumors Reviewed

    M. Natsumeda, H. Matsuzawa, M. Watanabe, K. Motohashi, R. Gabdulkhaev, Y. Tsukamoto, Y. Kanemaru, J. Watanabe, R. Ogura, M. Okada, S. Kurabe, K. Okamoto, A. Kakita, H. Igarashi, Y. Fujii

    American Journal of Neuroradiology   2022.10

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    DOI: 10.3174/ajnr.A7666

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  • Altered Functional Network Architecture of the Brain in Prader-Willi Syndrome. Reviewed International journal

    Kenichi Yamada, Kiyotaka Suzuki, Masaki Watanabe

    Brain connectivity   12 ( 2 )   174 - 179   2022.3

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    Background: Prader-Willi syndrome (PWS) is a genetic syndrome with clinical behavioral phenotypes, including autistic characteristics. However, brain functional connectivity (Fc) remains underreported. This study aimed at investigating alterations in functional network architecture in the cortical and subcortical structures of brains in individuals with PWS. Methods: Twelve individuals with PWS (age range: 15-42 years; female 4, male 8), and 14 age- and sex-matched controls with typical development (TD), participated in a 3 Tesla resting-state functional magnetic resonance imaging study. Fc was analyzed: (1) voxel-based group independent component analysis and correlations with Autism-Spectrum Quotient (AQ) scores, (2) seed-based neuroanatomical region of interest (ROI) analysis. Results: In individuals with PWS, AQ showed a significant positive correlation with Fc in the right frontal area, and the ROI analysis exhibited enhanced dorsolateral prefrontal Fcs compared with those in TD controls; the frontopolar-parietotemporal Fcs were attenuated. Discussion: The observed Fc indicated altered Fc in specific brain regions, which is consistent with the behavioral features in individuals with PWS. The enhanced versus attenuated connectivity in distinct frontal regions may contribute to not only autistic features but also other behavioral characteristics, and it provides a clue for better understanding of the brain-behavior relationship in PWS.

    DOI: 10.1089/brain.2020.0914

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  • Differential volume reductions in the subcortical, limbic, and brainstem structures associated with behavior in Prader-Willi syndrome. Reviewed International journal

    Kenichi Yamada, Masaki Watanabe, Kiyotaka Suzuki

    Scientific reports   12 ( 1 )   4978 - 4978   2022.3

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    Individuals with Prader-Willi syndrome (PWS) exhibit complex behavioral characteristics, including hyperphagia, autistic features, and subsequent age-related maladaptive behaviors. While this suggests functional involvements of subcortical, limbic, and brainstem areas, developmental abnormalities in such structures remain to be investigated systematically. Twenty-one Japanese individuals with PWS and 32 healthy controls with typical development were included. T1-weighted three-dimensional structural magnetic resonance images were analyzed for subcortical, limbic, and brainstem structural volumes, with age as a covariate, using a model-based automatic segmentation tool. Correlations were determined between each volume measurement and behavioral characteristics as indexed by questionnaires and block test scores for hyperphagia (HQ), autistic and obsessional traits, non-verbal intelligence (IQ), and maladaptive behavior (VABS_mal). Compared with the control group, the PWS group showed significantly reduced relative volume ratios per total intracranial volume (TIV) in thalamus, amygdala, and brainstem structures, along with TIV and native volumes in all substructures. While the brainstem volume ratio was significantly lower in all age ranges, amygdala volume ratios were significantly lower during early adulthood and negatively correlated to HQ and VABS_mal but positively correlated to Kohs IQ. Thus, limbic and brainstem volume alterations and differential volume trajectories may contribute to the developmental and behavioral pathophysiology of PWS.

    DOI: 10.1038/s41598-022-08898-3

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  • Reduced pituitary volume with relative T1 shortening correlates with behavior in Prader-Willi syndrome Reviewed

    Kenichi Yamada, Masaki Watanabe, Kiyotaka Suzuki

    Biomarkers in Neuropsychiatry   5   100039 - 100039   2021.12

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    DOI: 10.1016/j.bionps.2021.100039

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  • GlyCEST: Magnetic Resonance Imaging of Glycine-Distribution in the Normal Murine Brain and Alterations in 5xFAD Mice. Reviewed International journal

    Ken Ohno, Masaki Ohkubo, Bingwen Zheng, Masaki Watanabe, Tsuyoshi Matsuda, Ingrid L Kwee, Hironaka Igarashi

    Contrast media & molecular imaging   2021   8988762 - 8988762   2021

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    The glycine level in the brain is known to be altered in neuropsychiatric disorders, such as schizophrenia and Alzheimer's disease (AD). Several studies have reported the in vivo measurement of glycine concentrations in the brain using proton magnetic resonance spectroscopy (1H-MRS), but 1H-MRS is not capable of imaging the distribution of glycine concentration with high spatial resolution. Chemical exchange saturation transfer magnetic resonance imaging (CEST-MRI) is a new technology that can detect specific molecules, including amino acids, in tissues. To validate the measurements of glycine concentrations in living tissues using CEST from glycine to water (GlyCEST), we extracted the brain tissues from mice and performed biochemical tests. In wild-type C57BL/6 mice, GlyCEST effects were found to be higher in the thalamus than in the cerebral cortex (P < 0.0001, paired t-test), and this result was in good agreement with the biochemical results. In 5xFAD mice, an animal model of AD, GlyCEST measurements demonstrated that glycine concentrations in the cerebral cortex (P < 0.05, unpaired t-test) and thalamus (P < 0.0001, unpaired t-test), but not in the hippocampus, were decreased compared to those in wild-type mice. These findings suggest that we have successfully applied the CEST-MRI technique to map the distribution of glycine concentrations in the murine brain. The present method also captured the changes in cerebral glycine concentrations in mice with AD. Imaging the distribution of glycine concentrations in the brain can be useful in investigating and elucidating the pathological mechanisms of neuropsychiatric disorders.

    DOI: 10.1155/2021/8988762

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  • Application of 7 tesla magnetic resonance imaging for pediatric neurological disorders: Early clinical experience. Reviewed International journal

    Kenichi Yamada, Junichi Yoshimura, Masaki Watanabe, Kiyotaka Suzuki

    Journal of clinical imaging science   11   65 - 65   2021

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    Ultra-high field magnetic resonance imaging (MRI) has been introduced for use in pediatric developmental neurology. While higher magnetic fields have certain advantages, optimized techniques with specific considerations are required to ensure rational and safe use in children and those with pediatric neurological disorders (PNDs). Here, we summarize our initial experience with clinical translational studies that utilized 7 tesla (T)-MRI in the fields of developmental neurology. T2-reversed images and three-dimensional anisotropy contrast imaging enabled the depiction of targeted pathological brain structures with better spatial resolution. Diffusion imaging and susceptibility-weighted imaging enabled visualization of intracortical, subcortical, and intratumoral microstructures in vivo within highly limited scan times appropriate for patients with PNDs. 7T-MRI appears to have significant potential to enhance the depiction of the structural and functional properties of the brain, particularly those associated with atypical brain development.

    DOI: 10.25259/JCIS_185_2021

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  • Participant-driven Simulation Protocol With a Mock Scanner for Pediatric Magnetic Resonance Neuroimaging Preparation Without Sedation Reviewed

    Kenichi Yamada, Yuji Suzuki, Satoshi Ueki, Kosuke Itoh, Masaki Watanabe, Kiyotaka Suzuki, Hironaka Igarashi

    Clinical Simulation in Nursing   47   40 - 47   2020.10

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    DOI: 10.1016/j.ecns.2020.07.002

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  • プラダー・ウィリ症候群にみられる行動発達特性に関連した脳形態・機能的結合の特徴

    山田 謙一, 渡辺 将樹, 鈴木 清隆, 松澤 等, 鈴木 雄治

    脳と発達   52 ( Suppl. )   S340 - S340   2020.8

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    Language:Japanese   Publisher:(一社)日本小児神経学会  

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  • Cerebellar Volumes Associate with Behavioral Phenotypes in Prader-Willi Syndrome. Reviewed International journal

    Kenichi Yamada, Masaki Watanabe, Kiyotaka Suzuki, Yuji Suzuki

    Cerebellum (London, England)   2020.7

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    The objective of this study was to investigate lobule-specific cerebellar structural alterations relevant to clinical behavioral characteristics of Prader-Willi syndrome (PWS). We performed a case-control study of 21 Japanese individuals with PWS (age; median 21.0, range 13-50 years, 14 males, 7 females) and 40 age- and sex-matched healthy controls with typical development. Participants underwent 3-Tesla magnetic resonance imaging. Three-dimensional T1-weighted images were assessed for cerebellar lobular volume and adjusted for total intracerebellar volume (TIV) using a spatially unbiased atlas template to give a relative volume ratio. A region of interest analysis included the deep cerebellar nuclei. A correlation analysis was performed between the volumetric data and the clinical behavioral scores derived from the standard questionnaires (hyperphagia, autism, obsession, and maladaptive index) for global intelligence assessment in paired subgroups. In individuals with PWS, TIV was significantly reduced compared with that of controls (p < 0.05, family-wise error corrected; mean [standard deviation], 1014.1 [93.0] mm3). Decreased relative lobular volume ratios were observed in posterior inferior lobules with age, sex, and TIV as covariates (Crus I, Crus II, lobules VIIb, VIIIa, VIIIb, and IX). However, increased ratios were found in the dentate nuclei bilaterally in individuals with PWS (p < 0.01); the mean (standard deviation) × 10-3 was as follows: left, 1.58 (0.26); right, 1.67 (0.30). The altered lobular volume ratios showed negative correlations with hyperphagic and autistic characteristics and positive correlations with obsessive and intellectual characteristics. This study provides the first objective evidence of topographic patterns of volume differences in cerebellar structures consistent with clinical behavioral characteristics in individuals with PWS and strongly suggests a cerebellar contribution to altered functional brain connectivity in PWS.

    DOI: 10.1007/s12311-020-01163-1

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  • Developmental abnormalities of the brain exposed to childhood maltreatment detected by diffusion tensor imaging Reviewed

    Kenichi Yamada, Yuji Suzuki, Makiko Okuyama, Masaki Watanabe, Tsutomu Nakada

    Neurological Research   41 ( 1 )   19 - 25   2019.1

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    Publishing type:Research paper (scientific journal)   Publisher:Informa UK Limited  

    DOI: 10.1080/01616412.2018.1522413

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  • Advances and Challenges in Assessing 2-Hydroxyglutarate in Gliomas by Magnetic Resonance Spectroscopy: A Short Review Reviewed

    Manabu Natsumeda, Hironaka Igarashi, Kunio Motohashi, Yuji Suzuki, Masaki Ohkubo, Kouichirou Okamoto, Masaki Watanabe, Tsutomu Nakada, Yukihiko Fujii

    Neuropsychiatry (London)   8 ( 6 )   1831 - 1838   2018.7

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  • Novel Modified 3D Shepp-Logan Phantom Model for Simulation of MRI Radiofrequency Coil Design Reviewed

    Masaki Watanabe, Hitoshi Matsuzawa, Kenichi Yamada, Hironaka Igarashi, Tsutomu Nakada

    Advanced Biomedical Engineering   7 ( 0 )   156 - 159   2018

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Society for Medical and Biological Engineering  

    DOI: 10.14326/abe.7.156

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  • MRI characteristics of the glia limitans externa: A 7T study Reviewed

    Kiyotaka Suzuki, Kenichi Yamada, Kazunori Nakada, Yuji Suzuki, Masaki Watanabe, Ingrid L. Kwee, Tsutomu Nakada

    MAGNETIC RESONANCE IMAGING   44   140 - 145   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Purpose: To perform a systematic analysis of the intrinsic contrast parameters of the FLAIR hyperintense rim (FHR), a thin layer of high intensity covering the entire surface of the cerebral cortex detected on fluid-attenuated inversion recovery (FLAIR) sequence T-2 weighted imaging performed on a 7T system, in an attempt to identify its anatomical correlate.
    Methods: Fast spin echo inversion recovery (FSE-IR) and cardiac-gated fast spin echo (FSE) images were obtained with defined parameters in eight normal volunteers on a 7 T MRI system to determine T-2 and proton density, T-1 characteristics. K-means clustering analysis of parameter sets was performed using MATLAB version R2015b for the purpose of identifying the cluster reflecting FHR. The results were subsequently confirmed by independent component analysis (ICA) based on Ti behavior on FSE-IR using a MATLAB script of FastICA algorithm.
    Results: The structure giving rise to FHR was found to have a unique combination of intrinsic contrast parameters of low proton density, long T-2, and disproportionally short T-5. The findings are in strong agreement with the functional and structural specifics of the glia limitans externa (GLE), a structure composed of snuggled endfeet of astrocytes containing abundant aquaporin-4 (AQP-4), the main water channel of the brain.
    Conclusion: Intrinsic contrast parameters of FHR reflect structural and functional specifics of the GLE, and their values are highly dependent on the physiologic functionality of AQP-4. Microscopic imaging on a 7T system and analysis of GLE contrast parameters can be developed into a method for evaluating AQP-4 functionality.

    DOI: 10.1016/j.mri.2017.08.012

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  • Maturational decrease of glutamate in the human cerebral cortex from childhood to young adulthood: a H-1-MR spectroscopy study Reviewed

    Mami Shimizu, Yuji Suzuki, Kenichi Yamada, Satoshi Ueki, Masaki Watanabe, Hironaka Igarashi, Tsutomu Nakada

    PEDIATRIC RESEARCH   82 ( 5 )   749 - 752   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:NATURE PUBLISHING GROUP  

    BACKGROUND: The aim of the present study was to investigate maturational changes in glutamate (Glu) in the human cerebral cortex from childhood to young adulthood using 3.0-Tesla proton magnetic resonance spectroscopy (H-1-MRS), which is capable of quantifying Glu in vivo.
    METHODS: Normal volunteers comprising 11 children (aged 4-13 years) and 11 young adults (aged 18-33 years) participated in the study. Single-voxel point-resolved spectroscopy (PRESS, repetition time/echo time = 2,000/80 ms) was performed on the frontal and occipital cortices, and the Glu-to-creatine ratio (Glu/Cr) and N-acetylaspartate-to-creatine ratio (NAA/Cr) were determined.
    RESULTS: In both the frontal and occipital cortices, Glu/Cr was significantly lower during young adulthood relative to that during childhood. NAA/Cr did not differ significantly between the two age groups.
    CONCLUSION: This study has provided objective evidence that cerebral cortical Glu/Cr decreases between childhood and young adulthood. The observed decrease in Glu/Cr may reflect the simultaneous occurrence of maturational changes, such as changes in cortical microstructure and the intercellular compartmentation of Glu metabolism.

    DOI: 10.1038/pr.2017.101

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  • Slow accumulations of neural activities in multiple cortical regions precede self-initiation of movement: An event-related fMRI study Reviewed

    Honami Sakata, Kosuke Itoh, Yuji Suzuki, Katsuki Nakamura, Masaki Watanabe, Hironaka Igarashi, Tsutomu Nakada

    eNeuro   4 ( 5 )   ENEURO.0183 - 17.2017   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Society for Neuroscience  

    The neural processes underlying self-initiated behavior (behavior that is initiated without an external stimulus trigger) are not well understood. This event-related fMRI study investigated the neural origins of self-initiated behaviors in humans, by identifying brain regions that increased in neural activities several seconds prior to self-initiated movements. Subjects performed a hand grasping task under two conditions: a free-timing and cued timing condition. The supplementary motor area (SMA) began to activate several seconds prior to self-initiated movement (accounting for hemodynamic delay), representing a potential blood oxygenation level-dependent (BOLD) signal correlate of the readiness potential (RP) on electroencephalogram (EEG), referred to here as “readiness BOLD signals.” Significant readiness BOLD signals were also observed in the right frontoparietal areas, precuneus, and insula, all of which are known to contribute to internally-generated behaviors, but with no prior evidence for such early and slow accumulation of neural activities. Moreover, visual and auditory cortices also exhibited clear readiness BOLD signals with similar early onsets, even absent external stimulation. Slow accumulation of neural activities throughout distributed cortical areas, including sensory, association, and motor cortices, underlies the generation of self-initiated behaviors. These findings warrant reconsideration of the prevailing view that the SMA or some other specific locus in frontoparietal cortex serves as the ultimate neural origin of self-initiated movement.

    DOI: 10.1523/ENEURO.0183-17.2017

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  • High-contrast high-resolution imaging of posttraumatic mandibular nerve by 3DAC-PROPELLER magnetic resonance imaging: correlation with the severity of sensory disturbance Reviewed

    Makoto Terumitsu, Hitoshi Matsuzawa, Kenji Seo, Masaki Watanabe, Shigenobu Kurata, Akiko Suda, Tsutomu Nakada

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY   124 ( 1 )   85 - 94   2017.7

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    Objective. Magnetic resonance neurography reveals abnormal morphologies of regenerated nerves and overgrown connective tissue in injured trigeminal nerves, suggesting neuroma formation. We hypothesized that such deformities and scar formation contribute to pain symptoms.
    Study Design. High-contrast high-resolution magnetic resonance imaging was utilized to evaluate the inferior alveolar nerve and lingual nerve following traumatic injury in 19 patients. The relationship between the morphologic classification and severity of the sensory disorder was assessed.
    Results. In all cases, 3-dimensional anisotropy contrast periodically rotated overlapping parallel lines with enhanced reconstruction (3DAC-PROPELLER) successfully revealed the inner structures within the lesion. The isolated type represented the normal course of the nerve isolated from scar-like tissue (8 cases), whereas the deformity type included the deformed nerve either within scar-like tissue or by itself, unassociated with surrounding scar-like tissue (9 cases). In the remaining 2 cases, the nerve tissue and scar-like tissue were incorporated. Patients with the deformity type exhibited significantly more severe pain symptoms compared with patients with the isolated type.
    Conclusions. Overgrown connective tissue does not necessarily block regenerating nerves and itself may not cause pain. The morphologic findings on the 3DAC-PROPELLER were relevant to the severity of pain symptoms.

    DOI: 10.1016/j.oooo.2017.02.017

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  • Sleep Apnea in Multiple System Atrophy of Cerebellar Type: A 3.0 T MRS/Volumetry Pilot Study Reviewed

    Y. Takado, K. Terajima, T. Shimohata, H. Nakayama, M. Watanabe, K. Okamoto, T. Ozawa, M. Nishizawa, I. L. Kwee, H. Igarashi, T. Nakada

    eNeurologicalSci   6   6 - 8   2017.3

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    DOI: 10.1016/j.ensci.2016.10.002

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  • Visualization of the Intimal Flap in Intracranial Arterial Dissection Using High-Resolution 3T MRI Reviewed

    Masahiro Uemura, Kenshi Terajima, Yuji Suzuki, Masaki Watanabe, Yasuhisa Akaiwa, Shinichi Katada, Kouichirou Okamoto, Masatoyo Nishizawa, Hironaka Igarashi, Tsutomu Nakada

    JOURNAL OF NEUROIMAGING   27 ( 1 )   29 - 32   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY-BLACKWELL  

    BACKGROUND AND PURPOSE: Presence of an intimal flap is a critical imaging finding in diagnosing intracranial artery dissection (ICAD). Recent reports showed that high-resolution magnetic resonance imaging (MRI) was better at identifying intimal flaps as compared with routine MRI techniques used in clinical settings. However, no current standardized sequence for high-resolution MRI without gadolinium enhancement produces images of satisfactory quality with clinically tolerable scanning times. This study evaluated a nonenhanced high-resolution fast spin echo (HR-FSE) MRI sequence for visualizing intimal flaps in patients with ICAD.
    SUBJECTS AND METHODS: Three patients with ICAD underwent plain MRI examination using a 2-dimensional T2-weighted FSE imaging sequence optimized for our 3T system (in-plane pixel size, .23 mm x .23 mm; slice thickness 3 mm with no interslice gap), as well as scanning with conventional modalities, including CT angiography, magnetic resonance angiography, and digital subtraction angiography. We assessed whether these imaging methods could visualize an intimal flap and/or double lumen sign in the participants and compared the results between HR-FSE and the other modalities.
    RESULTS: HR-FSE images clearly showed intimal flaps and double lumen signs in all 3 patients, whereas the conventional modalities identified a double lumen sign in only 2 of the 3 patients.
    CONCLUSIONS: The present method of optimized HR-FSE imaging with a 3T system improved visualization of intimal flaps and should thus be considered for assessing patients with suspected ICAD that cannot be definitively diagnosed by conventional imaging modalities.

    DOI: 10.1111/jon.12380

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  • Cerebral venous sinus thrombosis due to oral contraceptive use: Postmortem 3 T-MRI and autopsy findings Reviewed

    Masahiro Uemura, Yoshihiro Tsukamoto, Yasuhisa Akaiwa, Masaki Watanabe, Ayako Tazawa, Sou Kasahara, Minoru Endou, Ryosuke Ogura, Kouichirou Okamoto, Yukihiko Fujii, Tsutomu Nakada, Akiyoshi Kakita, Masatoyo Nishizawa

    Human Pathology: Case Reports   6 ( 6 )   32 - 36   2016.12

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    Cerebral venous sinus thrombosis (CVST) is an uncommon form of stroke, and mortality of the acute phase is high. We report the clinical, postmortem 3 T-MRI, and autopsy features of a patient, 20-year-old Japanese woman, with CVST who died shortly after starting to use low-dose estrogen combined hormonal contraceptives (CHCs). A postmortem 3 T-MRI study with our originally developed system revealed abnormal intensities suggestive of thrombi extending throughout the straight sinus and left sigmoid sinus. At autopsy, in accordance with the images, we performed careful preparations of the sinuses. Histological examination revealed an organizing white thrombus occupying the lumen of the left sigmoid sinus, and an acute, red thrombus in the lumen of the left transverse, straight, and tentorial sinuses, and vein of Galen, indicating that the thrombus had developed first in the left sigmoid sinus, then extended retrogradely to the more proximal portion of the sinus system, reaching the vein of Galen. The features of the present CVST patient appear to be informative, when encountering CHC users with neurological symptoms, even in those who begun to use low-dose estrogen CHCs only recently.

    DOI: 10.1016/j.ehpc.2016.01.002

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  • The Posterior Limb of the Internal Capsule as the Subcortical Transitional Zone of the Anterior and Posterior Circulations: Insights from Human 7T MRI Reviewed

    Satoshi Kurabe, Kouichirou Okamoto, Kiyotaka Suzuki, Hisothi Matsuzawa, Masaki Watanabe, Yuji Suzuki, Tsutomu Nakada, Yukihiko Fujii

    CEREBROVASCULAR DISEASES   41 ( 5-6 )   256 - 264   2016

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:KARGER  

    Background: In patients with cerebral infarction, identifying the distribution of infarction and the relevant artery is essential for ascertaining the underlying vascular pathophysiological mechanisms and preventing subsequent stroke. However, visualization of the basal perforating arteries (BPAs) has had limited success, and simultaneous viewing of background anatomical structures has only rarely been attempted in living human brains. Our study aimed at identifying the BPAs with 7T MRI and evaluating their distribution in the subcortical structures, thereby showing the clinical significance of the technique. Methods: Twenty healthy subjects and 1 patient with cerebral infarction involving the posterior limb of the internal capsule (ICpost) and thalamus underwent 3-dimensional fast spoiled gradient-echo sequence as time-of-flight magnetic resonance angiography (MRA) at 7T with a submillimeter resolution. The MRA was modified to detect inflow signals from BPAs, while preserving the background anatomical signals. BPA stems and branches in the subcortical structures and their origins were identified on images, using partial maximum intensity projection in 3 dimensions. Results: A branch of the left posterior cerebral artery (PCA) in the patient ran through both the infarcted thalamus and ICpost and was clearly the relevant artery. In 40 intact hemispheres in healthy subjects, 571 stems and 1,421 branches of BPAs were detected in the subcortical structures. No significant differences in the numbers of stems and branches were observed between the intact hemispheres. The numbers deviated even less across subjects. The distribution analysis showed that the subcortical structures of the telencephalon, such as the caudate nucleus, anterior limb of the internal capsule, and lenticular nucleus, were predominantly supplied by BPAs from the anterior circulation. In contrast, the thalamus, belonging to the diencephalon, was mostly fed by BPAs from the posterior circulation. However, compared with other subcortical structures, the ICpost, which marks the anatomical boundary between the telencephalon and the diencephalon, was supplied by BPAs with significantly more diverse origins. These BPAs originated from the internal carotid artery (23.1%), middle cerebral artery (38.5%), PCA (17.3%), and the posterior communicating artery (21.1%). Conclusions: The modified MRI method allowed the detection of the relevant BPA within the infarcted in the stroke survivor as well as the BPAs in the subcortical structures of living human brains. Based on in vivo BPA distribution analyses, the ICpost is the transitional zone of the anterior and posterior cerebral circulations. (C) 2016 S. Karger AG, Basel

    DOI: 10.1159/000443538

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  • Separation of Perfusion Signals from Diffusion-Weighted Image Series Enabled by Independent Component Analysis Reviewed

    Kiyotaka Suzuki, Hironaka Igarashi, Masaki Watanabe, Yukihiro Nakamura, Tsutomu Nakada

    JOURNAL OF NEUROIMAGING   21 ( 4 )   384 - 394   2011.10

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    BACKGROUND AND PURPOSE
    An important task in diagnostic imaging of acute ischemic stroke is to identify the so-called diffusion-perfusion mismatch area. We aimed to investigate the possibility of facilitating the identification process by combining independent component analysis (ICA) and diffusion-weighted MRI (DWI), with the expectation that this would eliminate the need for additional perfusion imaging to delineate perfusion lesion.
    METHODS
    Simulations were performed to confirm the utility of an intuitively determined sequence of 14 b-factors ranging from 0 to 1,000 seconds/mm(2) for ICA separation of perfusion lesion. Corresponding DWI data from 2 stroke patients, 1 in the acute and 1 in the subacute phase, were decomposed into independent component (IC) maps, and their b-dependent amplitude decay profiles were subjected to multiexponential fitting.
    RESULTS
    Low-perfusion areas were successfully delineated on IC maps in both patients. Comparison with the areas of diffusion lesion identifiable on relatively high b-factor images in the DWI data, for example, those at b = 1,000 seconds/mm(2), allowed the mismatch to be identified.
    CONCLUSION
    This study demonstrates that combining ICA and DWI enables noninvasive mapping of sluggish perfusion provided an appropriate b-sequence is applied, and that it thereby facilitates the identification of diffusion-perfusion mismatch.

    DOI: 10.1111/j.1552-6569.2010.00514.x

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  • Automatic Measurement of Axial Length of Human Eye using Three-Dimensional Magnetic Resonance Imaging

    渡辺将樹, 渡辺将樹, 木竜徹

    生体医工学   49 ( 1 )   2011

  • Adult cerebellopontine angle medulloblastoma originating in the pons mimicking focal brainstem tumor. Reviewed International journal

    Junichi Yoshimura, Kenichi Nishiyama, Masafumi Fukuda, Masaki Watanabe, Hironaka Igarashi, Yukihiko Fujii

    Journal of neuroimaging : official journal of the American Society of Neuroimaging   19 ( 4 )   385 - 7   2009.10

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    We herein report a rare case of cerebellopontine angle (CPA) medulloblastoma originating in the brainstem that demonstrated a very unusual clinical presentation and radiological appearances. A 25-year-old female was admitted to our hospital with a right hearing disturbance and a right facial palsy. A small non-enhanced lesion having minimal mass effect in the right CPA was identified by using a 1.5-tesla-MR system, whose size remained almost unchanged a year. The 3-tesla MR images revealed that the precise region was in the right side of the tegmentum of the lower pons to the inferior cerebellar peduncle and the flocculus. MR spectroscopic images using a 3-tesla system revealed a high ratio of choline-to-N-acetylaspartate in the region of interest in comparison to the contra-lateral side. Craniotomy and biopsy were performed. The histopathological diagnosis was medulloblastoma. The patient received craniospinal irradiation and chemotherapy, and achieved complete remission by the time of the follow-up MR images. She is now doing well with a full recovery of the right facial palsy. MR spectroscopic imaging is considered to be quite useful for the management of this rare type of brainstem tumor.

    DOI: 10.1111/j.1552-6569.2008.00298.x

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  • Relationship between fusional limit and visual acuity in depth perception of binocular single vision Single ViSiOn

    Masaki Watanabe, Tohru Kiryu, Kiyotaka Suzuki, Kosuke Itoh, Tsutomu Nakada

    IEICE Technical Report   108 ( 179 )   159 - 162   2009.3

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  • Evaluation of post-procedure changes in aneurysmal lumen following detachable coil-placement using multi-planar reconstruction of high-field (3.0T) magnetic resonance angiography Reviewed

    Y. Yoneoka, M. Watanabe, K. Nishino, Y. Ito, I. L. Kwee, T. Nakada, Y. Fujii

    ACTA NEUROCHIRURGICA   150 ( 4 )   351 - 358   2008.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER WIEN  

    Background. Placement of detachable coil(s) for intracranial aneurysms has become one of the standard methods of management. Although detailed analysis of post-procedure changes in aneurysmal lumen is essential, technical difficulties often limit such evaluation. Development of higher magnetic field systems is steadily widening clinical usage of magnetic resonance imaging (MRI) primarily due to its significantly higher signal to noise ratio.
    Objective. In this study, we evaluated a multi-planar reconstruction (MPR) technique of magnetic resonance angiography (MRA) on a 3.0T system in an attempt to develop a routine method of post-procedure evaluation following detachable coil placement.
    Methods. Eleven patients with an intracranial aneurysm following placement of a Guglielmi detachable coil (GDC) participated in the study. Time of flight (TOF) magnetic resonance angiography (MRA) was obtained immediately after, and up to two years after coil embolisation utilising a GE 3.0T system. Data was analysed using standard maximum intensity projection (MIP) as well as the MPR technique and the results were compared to conventional catheter angiography.
    Results. The study demonstrated that, compared to MIP, MPR can provide further information of alteration in aneurysm lumen, especially in analysis of: 1) jet of blood flow, 2) thrombus formation, 3) neck remnant or re-filling of blood, 4) location and shape of coils including compaction, and 5) coil protrusion into the parent artery.
    Conclusions. Combined MPR/MIP analysis of high-field MRA appears to be a powerful non-invasive method for evaluating GDC-treatment that can potentially replace conventional catheter angiography in many clinical situations.

    DOI: 10.1007/s00701-008-1418-4

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  • All-phase MR Angiography Using Independent Component Analysis of Dynamic Contrast Enhanced MRI Time Series : φ-MRA Reviewed

    SUZUKI Kiyotaka, MATSUZAWA Hitoshi, IGARASHI Hironaka, WATANABE Masaki, NAKAYAMA Naoki, KWEE Ingrid L., NAKADA Tsutomu

    Magnetic Resonance in Medical Sciences   2 ( 1 )   23 - 27   2003.4

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    Dynamic contrast enhanced magnetic resonance imaging (dynamic MRI) represents a MRI version of <i>non-diffusible</i> tracer methods, the main clinical use of which is the physiological construction of what is conventionally referred to as perfusion images. The raw data utilized for constructing MRI perfusion images are time series of pixel signal alterations associated with the passage of a gadolinium containing contrast agent. Such time series are highly compatible with independent component analysis (ICA), a novel statistical signal processing technique capable of effectively separating a single mixture of multiple signals into their original independent source signals (blind separation). Accordingly, we applied ICA to dynamic MRI time series. The technique was found to be powerful, allowing for hitherto unobtainable assessment of regional cerebral hemodynamics <i>in vivo</i>.<br>

    DOI: 10.2463/mrms.2.23

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  • Gender difference in passive listening to stories: High-field fMRI study using multiple subject analysis based on individual activation maps Reviewed

    Koongliang Huang, Masaki Watanabe, Yukihiko Fujii, Ingrid L. Kwee, Tsutomu Nakada

    Magnetic Resonance in Medical Sciences   1 ( 3 )   165 - 168   2002

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    DOI: 10.2463/mrms.1.165

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MISC

  • ヘッドホン型コイルによる7T-MRIのヒト内耳分解能撮像

    渡辺 将樹, 松澤 等, 五十嵐 博中

    生体医工学シンポジウム2023   2023.9

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  • グリシンCEST-MRイメージング法の開発とアルツハイマー病モデルマウスへの応用

    大野 健, 計良 妙, 大久保 真樹, 渡辺 将樹, 松田 豪, 五十嵐 博中

    脳循環代謝   33 ( 1 )   119 - 119   2021.11

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    Language:Japanese   Publisher:(一社)日本脳循環代謝学会  

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  • 無鎮静小児MRI撮像のための統合的プレパレーション 被験者中心のプロトコール構築と実践

    山田 謙一, 鈴木 清隆, 鈴木 雄治, 渡辺 将樹

    脳と発達   53 ( 3 )   223 - 223   2021.5

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    Language:Japanese   Publisher:(一社)日本小児神経学会  

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  • 発達神経学領域における7テスラMRI臨床応用の初期経験

    山田 謙一, 吉村 淳一, 渡辺 将樹, 鈴木 清隆

    脳と発達   53 ( Suppl. )   S305 - S305   2021.5

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  • High resolution imaging of the human inner ear using 7T-MRI

    Masaki Watanabe, Hitoshi Matsuzawa, Hironaka Igarashi

    The 10 th NIPS-PRI-BRINU Joint Symposium   2021.3

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  • Endogenous brain activities preceding self-initiated movements Reviewed

    2019.7

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  • 内因性の意図に基づく自己開始運動に先行する脳活動

    酒多 穂波, 伊藤 浩介, 鈴木 雄治, 中村 克樹, 渡辺 将樹, 五十嵐 博中, 中田 力

    基礎心理学研究   37 ( 2 )   222 - 222   2019.3

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  • Endogenously initiated movements are preceded by neural activities in multiple cortical regions: an event-related fMRI study Reviewed

    Honami Sakata, Kosuke Itoh, Yuji Suzuki, Katsuki Nakamura, Masaki Watanabe, Hironaka Igarashi, Tsutomu Nakada

    47th Annual meeting of Society for Neuroscience   2017.11

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  • 内因性の意図に基づく運動に先行する神経活動

    酒多穂波, 伊藤浩介, 鈴木雄治, 中村克樹, 渡辺将樹, 五十嵐博中, 中田力

    第29回 臨床MR脳機能研究   2017.4

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  • 事象関連fMRIによる自由な意図の神経基盤の検討

    酒多穂波, 伊藤浩介, 鈴木雄治, 中村克樹, 渡辺将樹, 五十嵐博中, 中田力

    第6回 生理研-霊長研-脳研 合同シンポジウム   2017.3

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  • 【シーン別画像診断のいま-社会的要求への対応と課題[Scene Vol.9] オートプシー・イメージング(Ai)第五弾-社会インフラとしてのAiの普及と適切な活用に向けて-】 医学・教育・情報などの視点から考察するオートプシー・イメージング(Ai) 新潟大学脳研究所の取り組み 3T MRIを用いたAiと病理解剖

    塚本 佳広, 小倉 良介, 渡辺 将樹, 岡本 浩一郎, 五十嵐 博中, 柿田 明美

    INNERVISION   31 ( 1 )   45 - 47   2015.12

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    Language:Japanese   Publisher:(株)インナービジョン  

    新潟大学脳研究所は、脳神経外科と神経内科の臨床2科、神経病理部門、そして統合脳機能研究センターなどを有している。同センターの中田力名誉教授(当時・教授/センター長)の発案により実現した、3T MRIを用いた死後画像解析システムが稼働している。われわれのポリシーは、死亡時画像診断(以下、Ai)施行後直ちに病理解剖を行い、画像情報と組織所見を統合して病態理解につなげようとするものである。Aiを剖検の代替手段として行おうとするものではない。本稿では、神経疾患を対象として当研究所が取り組んでいる死後画像解析システムと病理解剖について紹介する。(著者抄録)

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  • 一側後大脳動脈から分岐する視床穿通動脈の走行に関する7T MRIを用いた検討

    倉部 聡, 松澤 等, 岡本 浩一郎, 鈴木 清隆, 渡辺 将樹, 中田 力, 伊藤 靖, 藤井 幸彦

    JNET: Journal of Neuroendovascular Therapy   9 ( 6 )   S295 - S295   2015.11

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    Language:Japanese   Publisher:(NPO)日本脳神経血管内治療学会  

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  • 三叉神経障害に対するPGA-C tubeによる生体内再生治療の高分解能神経MRIを用いた予後評価

    照光 真, 瀬尾 憲司, 松澤 等, 稲田 有史, 中村 達雄, 茂野 啓示, 渡辺 将樹, 鈴木 清隆, 中田 力

    末梢神経   26 ( 1 )   71 - 79   2015.6

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    三叉神経の神経障害性疼痛に対して、病変神経切除部位に人工神経PGA-C tubeを設置して神経再生を促す生体内再生治療はすでに臨床応用されている。患者で実際にどのように神経が再生されているのかを高分解能MRIにより検索した。再生神経の形態は、正常な解剖学的形態(2例)、正常形態であるが菲薄化(2例)、変形して再生、このうち変形には術前と同形態(3例)と異なる形態(2例)に分類された。正常もしくは菲薄化群は、症状と疼痛管理の改善度が、何らかの変形群に比し良好な傾向であった。再生神経の変形は正常な神経再生とは異なる再生過程による組織を反映したものと考えられる。(著者抄録)

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  • 死後3T MRI画像と神経病理解剖 新潟大学脳研究所の取組

    柿田 明美, 渡辺 将樹, 中田 力, 藤井 幸彦, 西澤 正豊

    法医病理   21 ( 1 )   3 - 3   2015.4

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Research Projects

  • 活動時機能画像のエントロピー解析を用いた発達性読み書き障害の脳活動の解明研究

    Grant number:20K20514

    2020.7 - 2025.3

    System name:科学研究費助成事業 挑戦的研究(開拓)

    Research category:挑戦的研究(開拓)

    Awarding organization:日本学術振興会

    鈴木 雄治, 酒多 穂波, 小枝 達也, 渡辺 将樹, 植木 智志

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    Grant amount:\25740000 ( Direct Cost: \19800000 、 Indirect Cost:\5940000 )

    発達性読み書き障害(Dyslexia)は、主に音韻処理に関する特異的な発達障害を呈し、約
    2%弱の学童が困難な状況にあると報告されている。適切な早期治療介入の機会が増し一定の効果が見込めるようになったが、読字における脳活動の異常メカニズムは解明されていない為、より高次な学習である漢字の読字や書字に対する効果的な介入は困難な状況のまま残されている。
    本研究では、超高磁場MRI装置のもつ特性を最大限に利用した脳機能画像のエントロピー解析に着目し、安静時及び読書時における脳活動の解析方法の開発研究を進める。fMRIデータにはミクロな機能連結の状態を反映する情報が含まれており、信号時系列のエントロピー解析によってランダムネス(複雑さの度合い)を評価できる。7.0T-fMRIの高空間分解能及び高信号雑音比を最大限に活かした撮像方法を用いることにより、個々の到達レベルに合わせた「読み」といった複雑な活動時の脳機能の詳細な評価を可能にするものと考えている。
    我々が提唱する情報理論的観点からのエントロピー解析は、脳活動をダイナミックに捉え
    てDyslexia特有の脳活動の異常メカニズムの評価を行う試みで、これは世界で類のない独創性・新規性があり、そこから得られる研究結果はDyslexia 児のみならず学校教育をはじめとした社会全体に大きな影響をもたらすことが期待できる挑戦的な研究である。新たなる非侵襲的な解析方法の開発は、様々な医療介入に伴う異常活動部位やパターンの変化の検出に繋がり、Dyslexiaの客観的な診断方法の開発や効果判定のツールとなることが期待できる。これは、問題を抱える児童に適切な環境・医療介入を与えることに貢献し、さらなる社会的状況の困難さの回避を可能とする。

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  • 7T MRIを用いたプラダー・ウィ リ症候群における行動発達特性 の脳基盤解明

    2017.4 - 2019.3

    Awarding organization:基盤研究(B) (一般)

    山田 謙一

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    Grant type:Competitive

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