Faculty Profiles - ODA Masafumi

Papers - ODA Masafumi

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Influence of intramedullary nail length for femoral subtrochanteric fracture model Reviewed

SANO Takumi, SAKURAI Kouta, SASAGAWA Keisuke, ODA Masafumi, SHIOTA Naohumi

The Proceedings of Mechanical Engineering Congress, Japan 2018 ( 0 ) J0270201 2018

Language：Japanese Publisher：The Japan Society of Mechanical Engineers

<p>Intramedullary nail fixation is one of the useful treatments for subtrochanteric fracture. The intramedullary nail used is selected from two types, long type and short type. In many cases, long intramedullary nail is applied to treatment of subtrochanteric fractures. However, there is discussion on application of long intramedullary nail from the viewpoint of minimally invasive. A middle intramedullary nail, which has an intermediate length between long type and short type, was developed. It is essential to conduct biomechanical investigations of the intramedullary nail systems subjected to various loads. The aim of this study was to investigate the influence of length of intramedullary nail for subtrochanteric fracture models with Seinsheimer classification IIB. Three types of intramedullary nail were considered: long type, middle type, and short type. Subtrochanteric fracture finite element (FE) models, which included the femoral fracture of Seinsheimer classification IIB and the intramedullary nail system, were developed. A 1-mm-thick callus layer was set in the gap between bone fragments of the femur. As a result of FE analysis, the effectiveness of middle intramedullary nail was indicated from the viewpoint of bone union and invasiveness.</p>

DOI： 10.1299/jsmemecj.2018.J0270201

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Influence of length of intramedullary nail implant on bone fragment fixation for femoral trochanteric fracture Reviewed

Keisuke SASAGAWA, Masafumi ODA, Naofumi SHIOTA

39 167 - 173 2018

Influence of torsional loading on intramedullary nail fixation for femoral subtrochanteric fracuture. Reviewed

38 47 - 54 2017.10

Consideration of shape design of artificial hip joint using numerical analysis method Reviewed

Japanese Journal of Clinical Biomechanics 38 259 - 265 2017.10

Biomechanical analysis using an elastioc modulus gradient model of an artificial hip stemp Reviewed

Japanese Journal of Clinical Biomechanics 38 267 - 274 2017.10

Biomechanical Effects of Stretching Exercise on Site of Femoral Subtrochanteric Fracture Reviewed

Aiko Noguchi, Keisuke Sasagawa, Masafumi Oda, Naofumi Shiota, Toru Sato, Toshiaki Hara

The Society of Life Support Engineering 29 ( 3 ) 100 - 105 2017.8

Selection of intramedullary nail system for femoral subtrochanteric fractures Reviewed

SASAGAWA Keisuke, ODA Masafumi, HARA Toshiaki, SHIOTA Naofumi

The Proceedings of Mechanical Engineering Congress, Japan 2017 ( 0 ) J0250102 2017

Numerical analysis investigation on optimal shape design for femoral stem Reviewed

SAKURAI Kota, SASAGAWA Keisuke, ODA Masafumi, HARA Toshiaki, NAKATA Katsuya, NOGUCHI Aiko

The Proceedings of Conference of Hokuriku-Shinetsu Branch 2017 ( 0 ) D031 2017

Biomechanical Investigation for Artificial hip stem with Gradient Function of Elastic Modulus Reviewed

Tanaka Keita, Sasagawa Keisuke, Hara Toshiaki, Oda Masafumi, Sakurai Kota, Noguchi Aiko

The Proceedings of Conference of Hokuriku-Shinetsu Branch 2017 ( 0 ) D032 2017

Liver-targeted hydrodynamic gene therapy: Recent advances in the technique Reviewed

Takeshi Yokoo, Kenya Kamimura, Hiroyuki Abe, Yuji Kobayashi, Tsutomu Kanefuji, Kohei Ogawa, Ryo Goto, Masafumi Oda, Takeshi Suda, Shuji Terai, Masafumi Oda

WORLD JOURNAL OF GASTROENTEROLOGY 22 ( 40 ) 8862 - 8868 2016.10

Language：English Publishing type：Research paper (scientific journal) Publisher：BAISHIDENG PUBLISHING GROUP INC

One of the major research focuses in the field of gene therapy is the development of clinically applicable, safe, and effective gene-delivery methods. Since the first case of human gene therapy was performed in 1990, a number of gene-delivery methods have been developed, evaluated for efficacy and safety, and modified for human application. To date, viral-vector-mediated deliveries have shown effective therapeutic results. However, the risk of lethal immune response and carcinogenesis have been reported, and it is still controversial to be applied as a standard therapeutic option. On the other hand, delivery methods for non-viral vector systems have been developed, extensively studied, and utilized in in vivo gene-transfer studies. Compared to viral-vector mediated gene transfer, nonviral systems have less risk of biological reactions. However, the lower gene-transfer efficiency was a critical hurdle for applying them to human gene therapy. Among a number of nonviral vector systems, our studies focus on hydrodynamic gene delivery to utilize physical force to deliver naked DNA into the cells in the living animals. This method achieves a high gene-transfer level by DNA solution injections into the tail vein of rodents, especially in the liver. With the development of genome editing methods, in vivo gene-transfer therapy using this method is currently the focus in this research field. This review explains the method principle, efficiency, safety, and procedural modifications to achieve a high level of reproducibility in large-animal models.

DOI： 10.3748/wjg.v22.i40.8862

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大腿骨転子下骨折の髄内釘固定術モデルにおける力学的検討 Reviewed

野口愛子, 笹川圭右, 尾田雅文, 塩田直史, 佐藤徹, 原利昭

臨床バイオメカニクス 37 173 - 179 2016.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本臨床バイオメカニクス学会

大腿骨転子下骨折に対する髄内釘法の適用では骨癒合のための整復位を保持することが難しく、固定力を高める目的でプレートが併用される。再手術に至った臨床例に基づいて構築した解析モデルに有限要素法によるシミュレーション解析を適用した。解析対象は60歳男性で、左大腿骨転子下骨折に髄内釘固定法を適用したが、偽関節およびインプラント破損に至り、新たな髄内釘とプレート固定併用により骨癒合が得られた。再術後CT画像を基に表面形状モデルを作成した。さらに3DCADソフトウェアを用いて大腿骨、髄内釘、プレート、スクリューのCADモデルを作成した。大腿骨転子下骨折治療における髄内釘インプラントの力学的状態と、プレート併用の影響を生体力学的に評価したところ、髄内釘固定治療におけるプレート追加の有用性が示された。骨折治療期間における繰り返し歩行荷重により、髄内釘インプラントの疲労破壊が生じる危険性も示唆された。

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高齢患者の多発骨盤骨折内固定における骨盤傾斜の影響 Reviewed

野口愛子, 勝山恵子, 笹川圭右, 尾田雅文, 塩田直史, 寺島正二郎, 原利昭

臨床バイオメカニクス 36 157 - 164 2015.10

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本臨床バイオメカニクス学会

高齢患者の多発骨盤骨折内固定における骨盤傾斜の影響について検討した。骨盤の両側骨折を受傷し、内固定術により骨折部をプレートとスクリューで固定した75歳女性の臨床データを解析対象とした。骨盤患部の術後X線CT画像を基に、骨盤、プレートおよびスクリューそれぞれの三次元形状モデルを作成した。その結果、骨盤姿勢の後傾により、骨盤への負荷は増加傾向を示した。骨盤後傾姿勢では、インプラントへの負荷は増加傾向にあり、破損の危険性が高まることが示唆された。

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大腿骨ステム境界面におけるすべり量とステム長の関係 Reviewed

櫻井航太, 笹川圭右, 勝山恵子, 原利昭, 寺島正二郎, 尾田雅文, 中田活也

臨床バイオメカニクス 36 171 - 180 2015.10

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本臨床バイオメカニクス学会

大腿骨ステム境界面におけるすべり量とステム長の関係について検討した。標準型セメントレスステムの人工股関節置換術(THA)を施行した10例(全例女性、平均67.0±6.3歳)を解析対象とした。THAの術前および術後にCT撮影を行った。術前および術後のCTスライス画像から、三次元画像再構築ソフトを用いて、大腿骨およびステムそれぞれの表面形状モデルを構築した。大腿骨の有限要素(FE)モデルには、術前CT画像から構築した大腿骨モデルとステムCADモデルをFEモデル構築に使用した。ステム長が50〜100%までの短縮化ならば初期固定性への影響は少なかった。ステム長の短縮化が30〜40%にかけては初期固定性が著しく低下した。

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Quantitative single-cell motility analysis of platelet-rich plasma-treated endothelial cells in vitro Reviewed

Tomoyuki Kawase, Takaaki Tanaka, Kazuhiro Okuda, Makoto Tsuchimochi, Masafumi Oda, Toshiaki Hara

CYTOSKELETON 72 ( 5 ) 246 - 255 2015.5

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

Platelet-rich plasma (PRP) has been widely applied in regenerative therapy due to its high concentration of growth factors. Previous in vitro and in vivo studies have provided evidence supporting the angiogenic activity of PRP. To more directly demonstrate how PRP acts on endothelial cells, we examined the PRP-induced changes in the motility of human umbilical vein endothelial cells by examining the involvement of VEGF. Time-lapse quantitative imaging demonstrated that in the initial phase (approximate to 2 h) of treatment, PRP substantially stimulated cell migration in a wound-healing assay. However, this effect of PRP was not sustained at significant levels beyond the initial phase. The average net distance of cell migration at 10 h was 0.45 +/- 0.16 mm and 0.82 +/- 0.23 mm in control and PRP-stimulated cells, respectively. This effect was also demonstrated with recombinant human VEGF and was significantly attenuated by a neutralizing anti-VEGF antibody. Immunofluorescent examination of paxillin and actin fibers demonstrated that PRP concomitantly up-regulated focal adhesion and cytoskeletal formation. Western blotting analysis of phosphorylated VEGFR2 demonstrated that PRP mainly stimulated the phosphorylation of immature VEGFR2 in a dose- and time-dependent manner, an action that was completely blocked by the neutralizing antibody. Taken together, these data suggest that PRP acts directly on endothelial cells via the activation of VEGFR2 to transiently up-regulate their motility. Thus, the possibility that PRP desensitizes target endothelial cells for a relatively long period of time after short-term activation should be considered when the controlled release system of PRP components is designed. (c) 2015 Wiley Periodicals, Inc.

DOI： 10.1002/cm.21221

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An atmospheric-pressure plasma-treated titanium surface potentially supports initial cell adhesion, growth, and differentiation of cultured human prenatal-derived osteoblastic cells Reviewed

Tomoyuki Kawase, Takaaki Tanaka, Hiromi Minbu, Mana Kamiya, Masafumi Oda, Toshiaki Hara

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 102 ( 6 ) 1289 - 1296 2014.8

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

An atmospheric-pressure plasma (APP) treatment was recently reported to render titanium (Ti) surfaces more suitable for osteoblastic cell proliferation and osteogenesis. However, the mechanism of action remains to be clearly demonstrated. In this study, we focused on cell adhesion and examined the effects of the APP treatment on the initial responses of human prenatal-derived osteoblastic cells incubated on chemically polished commercially pure Ti (CP-cpTi) plates. In the medium containing 1% fetal bovine serum, the initial cell adhesion and the actin polymerization were evaluated by scanning electron microscopy and fluorescence microscopy. The expression of cell adhesion-related molecules and osteoblast markers at the messenger RNA level was assessed by real-time quantitative polymerase chain reaction. Although the cells on the APP-treated CP-cpTi surface developed fewer cytoskeletal actin fibers, they attached with higher affinity and consequently proliferated more actively (1.46-fold over control at 72 h). However, most of the cell adhesion molecule genes were significantly downregulated (from 40 to 85% of control) in the cells incubated on the APP-treated CP-cpTi surface at 24 h. Similarly, the osteoblast marker genes were significantly downregulated (from 49 to 63% of control) at 72 h. However, the osteoblast marker genes were drastically upregulated (from 197 to 296% of control) in these cells by dexamethasone and beta-glycerophosphate treatment. These findings suggest that the APP treatment improves the ability of the CP-cpTi surface to support osteoblastic proliferation by enhancing the initial cell adhesion and supports osteoblastic differentiation when immature osteoblasts begin the differentiation process. (C) 2014 Wiley Periodicals, Inc.

DOI： 10.1002/jbm.b.33114

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Novel electric power-driven hydrodynamic injection system for gene delivery: Safety and efficacy of human factor IX delivery in rats Reviewed

T. Yokoo, K. Kamimura, T. Suda, T. Kanefuji, M. Oda, G. Zhang, D. Liu, Y. Aoyagi

Gene Therapy 20 ( 8 ) 816 - 823 2013.8

Language：English Publishing type：Research paper (scientific journal)

The development of a safe and reproducible gene delivery system is an essential step toward the clinical application of the hydrodynamic gene delivery (HGD) method. For this purpose, we have developed a novel electric power-driven injection system called the HydroJector-EM, which can replicate various time-pressure curves preloaded into the computer program before injection. The assessment of the reproducibility and safety of gene delivery system in vitro and in vivo demonstrated the precise replication of intravascular time-pressure curves and the reproducibility of gene delivery efficiency. The highest level of luciferase expression (272 pg luciferase per mg of proteins) was achieved safely using the time-pressure curve, which reaches 30 mm Hg in 10 s among various curves tested. Using this curve, the sustained expression of a therapeutic level of human factor IX protein (&gt
500 ng ml-1) was maintained for 2 months after the HGD of the pBS-HCRHP-FIXIA plasmid. Other than a transient increase in liver enzymes that recovered in a few days, no adverse events were seen in rats. These results confirm the effectiveness of the HydroJector-EM for reproducible gene delivery and demonstrate that long-term therapeutic gene expression can be achieved by automatic computer-controlled hydrodynamic injection that can be performed by anyone. © 2013 Macmillan Publishers Limited.

DOI： 10.1038/gt.2013.2

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Mechanical Evaluation for Fitting of NPPV Nasal Mask Reviewed

Masafumi Oda, Keiichi Ninomiya, Toshiaki Hara

Journal of Life Support Engineering 25 ( 4 ) 124 - 129 2013

Development of a capacitance type 6 axis force sensor Reviewed

Masafumi ODA, Toshiaki HARA

Life Support 23 ( 3 ) 116 - 123 2011.10

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Society of Life Support Engineering

We have been developing a novel capacitance type force sensor that enables simultaneous measurement of a torque around the vertical axis as well as normal and two orthogonal shear forces on the skin surface. In our previous research, the prototype sensors were made and authenticated the potency. Prototype sensors are parallel plate type collocated a dielectric between two circuits. We have planned to use an approximated displacement-capacitance characteristic curve when we estimate an output force. Therefore, this paper reports about an ideal approximation of the curve and several applications, such as surgical robot and nursing-care system.

DOI： 10.5136/lifesupport.23.116

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Other Link： http://search.jamas.or.jp/link/ui/2012056612

Primary stability of tapered wedge-shaped cementless stems in patients with stvepipe canal and type c bone: Biomechanical estimation of primary micromotion Reviewed

Katsuya NAKATA

Journal of Japanese Society for Joint Diseases 29 ( 4 ) 485 - 494 2010.12

FE model construction for stress analysis on NPPV nasal mask Reviewed

Keiichi NINOMIYA, Yuusuke YOSHIDA, Masafumi ODA

24 ( 4 ) 23 - 26 2009.12

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Papers - ODA Masafumi