Faculty Profiles - WAKAI Toshifumi

MISC - WAKAI Toshifumi

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FTY720, a Sphingosine-1-phosphate receptor modulator, as a novel targeted therapy against colitis-associated cancer

Masayuki Nagahashi, Jie Liang, Akimitsu Yamada, Wei-Ching Huang, Yu Koyama, Toshifumi Wakai, Sheldon Milstien, Sarah Spiegel, Kazuaki Takabe

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 219 ( 4 ) E73 - E73 2014.10

5 潰瘍性大腸炎に合併する大腸腫瘍におけるサーベイランス内視鏡検査の臨床的意義（Ⅱ.主題「IBDに合併した癌」, 第69回新潟大腸肛門病研究会）

伏木麻恵, 島田能史, 木戸知紀, 中野雅人, 亀山仁史, 野上仁, 若井俊文

新潟医学会雑誌 128 ( 9 ) 467 - 467 2014.9

Sphingosine-1-Phosphate Signaling Targeted Therapy Suppresses Obesity-Related Breast Cancer Progression and Improves Survival

Masayuki Nagahashi, Akimitsu Yamada, Tomoyoshi Aoyagi, Krista P. Terracina, Yu Koyama, Toshifumi Wakai, Kazuaki Takabe

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 219 ( 3 ) S126 - S126 2014.9

【いわゆる「早期胆嚢癌」に関する問題点を整理する】早期胆嚢癌の病理

永橋昌幸, 廣瀬雄己, 三浦宏平, 大橋拓, 丸山智宏, 滝沢一泰, 坂田純, 小林隆, 皆川昌広, 若井俊文, 味岡洋一

胆と膵 35 ( 9 ) 801 - 806 2014.9

Language：Japanese Publisher：医学図書出版(株)

早期胆嚢癌317例を用いて、その肉眼的・組織学的特徴を検討した。肉眼型別頻度は、隆起型が37.2%(118例)で、表面型が62.8%(199例)であった。術前あるいは術中に胆嚢癌と診断し得た割合は、隆起型では78.8%(93/118)、表面型では24.6%(49/199)であり、表面型は術前・術中診断率が有意に低かった(P<0.001)。早期胆嚢癌317例中315例が腺癌で、そのうち91.5%(286/315)が乳頭腺癌あるいは高分化型管状腺癌であった。癌の局所進展度別頻度は、Tis(M)癌もしくはT1a(M)癌が85.8%(272例)、T1b(MP)癌が14.2%(45例)であった。リンパ管浸潤をT1b(MP)癌の1例で認めたが、静脈浸潤、神経浸潤、リンパ節転移は早期胆嚢癌317例全例で陰性であった。本稿では、胆嚢の前癌病変、初期癌病変を含む早期胆嚢癌に関する学術的用語について言及し、従来の研究成果を概括することにより、早期胆嚢癌の病理組織学的特徴を解説する。(著者抄録)

J-GLOBAL

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5 若年者に対する腹腔鏡下脾温存尾側膵切除の1例（Ⅰ.一般演題, 第22回新潟内視鏡外科研究会）

128 ( 8 ) 404 - 404 2014.8

4 網嚢側から膵下縁レベルでの剥離を先行した脾弯曲部の授動（Ⅰ.一般演題, 第22回新潟内視鏡外科研究会）

中野雅人, 野上仁, 木戸知紀, 伏木麻恵, 島田能史, 亀山仁史, 丸山聡, 瀧井康公, 若井俊文

新潟医学会雑誌 128 ( 8 ) 404 - 404 2014.8

24 膵・胆管合流異常症に合併した胆嚢癌8例の検討（一般演題, 第275回新潟外科集談会）

128 ( 7 ) 341 - 341 2014.7

15 同一病巣内にカルチノイドと腺癌の両者の成分を認めた直腸腫瘍の1例（一般演題, 第275回新潟外科集談会）

木戸知紀, 伏木麻恵, 中野雅人, 島田能史, 亀山仁史, 野上仁, 若井俊文, 岩渕三哉

新潟医学会雑誌 128 ( 7 ) 338 - 338 2014.7

ホルマリン固定パラフィン包埋標本でのプロテオミクス解析の可能性

長谷川美樹, 小山諭, 坂田英子, 辰田久美子, 利川千絵, 萬羽尚子, 五十嵐麻由子, 若井俊文

日本乳癌学会総会プログラム抄録集 22回 325 - 325 2014.7

Feasibility of the Early Post-Operative Endoscopic Retrograde Cholangiography for Biliary Strictures After Adult Living Donor Liver Transplantation

T. Kobayashi, K. Miura, H. Ishikawa, D. Soma, K. Takizawa, K. Takano, J. Sakata, M. Minagawa, T. Wakai

TRANSPLANTATION 98 793 - 793 2014.7

Long-Term Follow-Up Study of Biliary Reconstructions and Complications After Adult Living Donor Liver Transplantation

H. Ishikawa, T. Kobayashi, K. Miura, D. Soma, K. Takizawa, K. Takano, J. Sakata, M. Minagawa, Y. Koyama, T. Wakai

TRANSPLANTATION 98 795 - 795 2014.7

Long-Term Follow-Up Study of Biliary Reconstructions and Complications After Adult Living Donor Liver Transplantation.

H. Ishikawa, T. Kobayashi, K. Miura, D. Soma, K. Takizawa, K. Takano, J. Sakata, M. Minagawa, Y. Koyama, T. Wakai

AMERICAN JOURNAL OF TRANSPLANTATION 14 795 - 795 2014.6

Feasibility of the Early Post-Operative Endoscopic Retrograde Cholangiography for Biliary Strictures After Adult Living Donor Liver Transplantation.

T. Kobayashi, K. Miura, H. Ishikawa, D. Soma, K. Takizawa, K. Takano, J. Sakata, M. Minagawa, T. Wakai

AMERICAN JOURNAL OF TRANSPLANTATION 14 793 - 793 2014.6

Development and external validation of a nomogram for overall survival after curative resection in serosa-negative, locally advanced gastric cancer

S. Hirabayashi, S. Kosugi, Y. Isobe, A. Nashimoto, I. Oda, K. Hayashi, I. Miyashiro, S. Tsujitani, Y. Kodera, Y. Seto, H. Furukawa, H. Ono, S. Tanabe, M. Kaminishi, S. Nunobe, T. Fukagawa, R. Matsuo, T. Nagai, H. Katai, T. Wakai, K. Akazawa

ANNALS OF ONCOLOGY 25 ( 6 ) 1179 - 1184 2014.6

Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：OXFORD UNIV PRESS

Few nomograms can predict overall survival (OS) after curative resection of advanced gastric cancer (AGC), and these nomograms were developed using data from only a few large centers over a long time period. The aim of this study was to develop and externally validate an elaborative nomogram that predicts 5-year OS after curative resection for serosa-negative, locally AGC using a large amount of data from multiple centers in Japan over a short time period (2001-2003).
Of 39 859 patients who underwent surgery for gastric cancer between 2001 and 2003 at multiple centers in Japan, we retrospectively analyzed 5196 patients with serosa-negative AGC who underwent Resection A according to the 13th Japanese Classification of Gastric Carcinoma. The data of 3085 patients who underwent surgery from 2001 to 2002 were used as a training set for the construction of a nomogram and Web software. The data of 2111 patients who underwent surgery in 2003 were used as an external validation set.
Age at operation, gender, tumor size and location, macroscopic type, histological type, depth of invasion, number of positive and examined lymph nodes, and lymphovascular invasion, but not the extent of lymphadenectomy, were associated with OS. Discrimination of the developed nomogram was superior to that of the TNM classification (concordance indices of 0.68 versus 0.61; P < 0.001). Moreover, calibration was accurate.
We have developed and externally validated an elaborative nomogram that predicts the 5-year OS of postoperative serosa-negative AGC. This nomogram would be helpful in the assessment of individual risks and in the consideration of additional therapy in clinical practice, and we have created freely available Web software to more easily and quickly predict OS and to draw a survival curve for these purposes.

DOI： 10.1093/annonc/mdu125

Web of Science

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Association of Tumor Budding with Clinicopathological Characteristics and Prognosis in Pancreatic Ductal Adenocarcinoma

Takizawa Kazuyasu, Wakai Toshifumi

128 ( 5 ) 216 - 226 2014.5