Updated on 2025/10/09

写真a

 
HASEGAWA Isao
 
Organization
Academic Assembly Institute of Medicine and Dentistry IGAKU KEIRETU Professor
Faculty of Medicine School of Medicine Professor
Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Regenerative and Transplant Medicine Professor
Title
Professor
Homepage
http://kaken.nii.ac.jp/ja/r/60282620
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External link

Degree

  • 博士(医学) ( 1999.10   東京大学 )

Research Interests

  • 前頭葉

  • マカクザル

  • 眼球運動

  • 電気生理

  • 大脳

  • 磁気共鳴画像

  • 単一神経活動

  • 体性感覚野

  • スプリットブレイン

  • 側頭葉

  • 視覚

  • 記憶検索

  • 包括脳ネットワーク

Research Areas

  • Life Science / Neuroscience-general

  • Life Science / Physiology

  • Life Science / Clinical pharmacy

Research History (researchmap)

  • 新潟大学 医学部生理学教室   教授

    2007.10

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  • Teikyo University   Chiba Medical Center

    2006.4 - 2007.9

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  • 墨田中央病院脳神経外科   医長

    2003.9 - 2006.3

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  • 東京大学 大学院・医学系研究科   講師

    2000.6 - 2003.9

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  • 東京大学 大学院・医学系研究科   助手

    1999

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  • 東京大学 医学系研究科   助手

    1996.7 - 2000.6

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Research History

  • Niigata University   Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Regenerative and Transplant Medicine   Professor

    2007.10

  • Niigata University   Faculty of Medicine School of Medicine   Professor

    2007.10

 

Papers

  • Optogenetically‐induced sustained hypothalamic hyperexcitability impairs memory via thalamic spread

    Masaki Sonoda, Hisao Aimi, Keisuke Kawasaki, Haruo Toda, Shinobu Hirai, Masao Horie, Reiko Meguro, Eishi Asano, Haruo Okado, Shigeki Kameyama, Tetsuya Yamamoto, Isao Hasegawa

    Epilepsia   2025.3

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    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    Objective

    Clinical investigators have hypothesized that interictal epileptiform discharges (IEDs) generated by hypothalamic hamartoma (HH) lead to cognitive dysfunction in patients with drug‐resistant gelastic seizures. Herein we provide causal evidence supporting this hypothesis by demonstrating that excitatory neural bursts, when propagating from the HH to the mediodorsal thalamus during the encoding period, impair working memory.

    Methods

    By employing channelrhodopsin‐2 photostimulation, we induced excessive neural excitation in Long‐Evans rats, resembling IEDs, at the axon terminals of the lateral hypothalamus projecting toward the mediodorsal thalamus and prelimbic cortex. We recorded local field potentials (LFPs) at these sites and assessed the performance of working memory tasks with and without photostimulation. Utilizing support vector machine analysis on LFP trials under sham photostimulation, we identified the neural correlates of successful task performance. Through mixed model analyses, we evaluated the impacts of photostimulation timing and the alteration in LFP amplitude induced by photostimulation on task performance.

    Results

    Ten rats completed operant conditioning using a spout lever system after receiving an average of 70.7 days of training, at a rate of 135.2 trials per day. During sham photostimulation, successful trials were associated with a shorter duration of the working memory maintenance period, as well as an augmentation in the 10‐ to 14‐Hz LFP amplitude at the mediodorsal thalamus and prelimbic cortex during the memory encoding phase. Photostimulation at the mediodorsal thalamus during encoding reduced the odds of a trial being successful by 0.19. Conversely, excessive mediodorsal thalamus LFP augmentation induced by photostimulation during encoding increased the odds of a trial being unsuccessful by 1.04.

    Significance

    Excessive neural excitation, specifically propagating from the lateral hypothalamus to the mediodorsal thalamus during encoding, alters physiological neural activity and transiently impairs working memory. This study clarifies the pathophysiological mechanism underlying cognitive disabilities associated with working memory impairment in HH‐related epileptic encephalopathy.

    DOI： 10.1111/epi.18321

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  • The Role of Dual-step Linguistic Structuring in Self-paced Reading Rhythms

    Ryutaro KASEDO, Atsuhiko IIJIMA, Kiyoshi NAKAHARA, Yusuke ADACHI, Fumitaka HOMAE, Ryu-ichiro HASHIMOTO, Isao HASEGAWA

    Advanced Biomedical Engineering   13   343 - 353   2024

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    Publishing type：Research paper (scientific journal)   Publisher：Japanese Society for Medical and Biological Engineering  

    DOI： 10.14326/abe.13.343

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  • Mapping information flow between the inferotemporal and prefrontal cortices via neural oscillations in memory retrieval and maintenance. Reviewed International journal

    Tao Zhou, Keisuke Kawasaki, Takafumi Suzuki, Isao Hasegawa, Anna Wang Roe, Hisashi Tanigawa

    Cell reports   42 ( 10 )   113169 - 113169   2023.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    Interaction between the inferotemporal (ITC) and prefrontal (PFC) cortices is critical for retrieving information from memory and maintaining it in working memory. Neural oscillations provide a mechanism for communication between brain regions. However, it remains unknown how information flow via neural oscillations is functionally organized in these cortices during these processes. In this study, we apply Granger causality analysis to electrocorticographic signals from both cortices of monkeys performing visual association tasks to map information flow. Our results reveal regions within the ITC where information flow to and from the PFC increases via specific frequency oscillations to form clusters during memory retrieval and maintenance. Theta-band information flow in both directions increases in similar regions in both cortices, suggesting reciprocal information exchange in those regions. These findings suggest that specific subregions function as nodes in the memory information-processing network between the ITC and the PFC.

    DOI： 10.1016/j.celrep.2023.113169

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  • Decoding distributed oscillatory signals driven by memory and perception in the prefrontal cortex Reviewed

    Hisashi Tanigawa, Kei Majima, Ren Takei, Keisuke Kawasaki, Hirohito Sawahata, Kiyoshi Nakahara, Atsuhiko Iijima, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa

    Cell Reports   39 ( 2 )   110676 - 110676   2022.4

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.celrep.2022.110676

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  • Mental construction of object symbols from meaningless elements by Japanese macaques (Macaca fuscata). Reviewed International journal

    Nanxi Liu, Atsuhiko Iijima, Yutaka Iwata, Kento Ohashi, Nobuyoshi Fujisawa, Toshikuni Sasaoka, Isao Hasegawa

    Scientific reports   12 ( 1 )   3566 - 3566   2022.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    When writing an object's name, humans mentally construct its spelling. This capacity critically depends on use of the dual-structured linguistic system, in which meaningful words are represented by combinations of meaningless letters. Here we search for the evolutionary origin of this capacity in primates by designing dual-structured bigram symbol systems where different combinations of meaningless elements represent different objects. Initially, we trained Japanese macaques (Macaca fuscata) in an object-bigram symbolization task and in a visually-guided bigram construction task. Subsequently, we conducted a probe test using a symbolic bigram construction task. From the initial trial of the probe test, the Japanese macaques could sequentially choose the two elements of a bigram that was not actually seen but signified by a visually presented object. Moreover, the animals' spontaneous choice order bias, developed through the visually-guided bigram construction learning, was immediately generalized to the symbolic bigram construction test. Learning of dual-structured symbols by the macaques possibly indicates pre-linguistic adaptations for the ability of mentally constructing symbols in the common ancestors of humans and Old World monkeys.

    DOI： 10.1038/s41598-022-07563-z

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  • Theory of mind tested by implicit false belief: a simple and full‐fledged mental state attribution Reviewed

    Jun Egawa, Keisuke Kawasaki, Taketsugu Hayashi, Ryota Akikawa, Toshiyuki Someya, Isao Hasegawa

    The FEBS Journal   2022.1

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1111/febs.16322

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  • Prediction-Related Frontal-Temporal Network for Omission Mismatch Activity in the Macaque Monkey. Reviewed International journal

    Yuki Suda, Mariko Tada, Takeshi Matsuo, Keisuke Kawasaki, Takeshi Saigusa, Maho Ishida, Tetsuo Mitsui, Hironori Kumano, Kenji Kirihara, Takafumi Suzuki, Kenji Matsumoto, Isao Hasegawa, Kiyoto Kasai, Takanori Uka

    Frontiers in psychiatry   13   557954 - 557954   2022

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    Language：English   Publishing type：Research paper (scientific journal)  

    Sensory prediction is considered an important element of mismatch negativity (MMN) whose reduction is well known in patients with schizophrenia. Omission MMN is a variant of the MMN which is elicited by the absence of a tone previously sequentially presented. Omission MMN can eliminate the effects of sound differences in typical oddball paradigms and affords the opportunity to identify prediction-related signals in the brain. Auditory predictions are thought to reflect bottom-up and top-down processing within hierarchically organized auditory areas. However, the communications between the various subregions of the auditory cortex and the prefrontal cortex that generate and communicate sensory prediction-related signals remain poorly understood. To explore how the frontal and temporal cortices communicate for the generation and propagation of such signals, we investigated the response in the omission paradigm using electrocorticogram (ECoG) electrodes implanted in the temporal, lateral prefrontal, and orbitofrontal cortices of macaque monkeys. We recorded ECoG data from three monkeys during the omission paradigm and examined the functional connectivity between the temporal and frontal cortices by calculating phase-locking values (PLVs). This revealed that theta- (4-8 Hz), alpha- (8-12 Hz), and low-beta- (12-25 Hz) band synchronization increased at tone onset between the higher auditory cortex and the frontal pole where an early omission response was observed in the event-related potential (ERP). These synchronizations were absent when the tone was omitted. Conversely, low-beta-band (12-25 Hz) oscillation then became stronger for tone omission than for tone presentation approximately 200 ms after tone onset. The results suggest that auditory input is propagated to the frontal pole via the higher auditory cortex and that a reciprocal network may be involved in the generation of auditory prediction and prediction error. As impairments of prediction may underlie MMN reduction in patients with schizophrenia, an aberrant hierarchical temporal-frontal network might be related to this pathological condition.

    DOI： 10.3389/fpsyt.2022.557954

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  • Development of a Self-paced Sequential Letterstring Reading Task to Capture the Temporal Dynamics of Reading a Natural Language

    Kasedo Ryutaro, Iijima Atsuhiko, Nakahara Kiyoshi, Adachi Yusuke, Hasegawa Isao

    Advanced Biomedical Engineering   10 ( 0 )   26 - 31   2021

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    Language：English   Publisher：Japanese Society for Medical and Biological Engineering  

    <p>The rhythm of vocalizing a written language depends on a merge process that combines meaningless linguistic units into a meaningful lexical unit, word, or Bunsetsu in Japanese. However, in most previous studies, written language was presented to the participants in lexical units (word-by-word) with explicit inter-word (or inter-Bunsetsu) marks or spacing. Therefore, it has been difficult to conduct psychophysical assessment of the participants' own speed in segmenting meaningful units from unstructured written language when reading. Here, we hypothesized that the spontaneous reading speed of Japanese readers reflects their own punctuation process, even when sentences are written without punctuation marks or spaces. To test this hypothesis, we developed a new "self-paced sequential letterstring reading task," which visually presents sentences letter-by-letter. The task required participants to push a button to proceed to the next letter at their own pace, hence allowing evaluation of the reaction time (RT) to individual letters. We found that the average RT decreased parametrically as the position of the letter approached the end of a Bunsetsu. Moreover, the RT increased drastically at the last letter completing the Bunsetsu. Participants were not shown any punctuation marks and not instructed to explicitly recognize the punctuations during reading. Therefore, these effects strongly suggest that the implicit and spontaneous punctuation is the origin of the rhythm in reading. These results show that spontaneous punctuation of letterstring affects the reading speed. The task we have developed is a promising tool for revealing the temporal dynamics of natural reading, which opens a way to shape the fluency of script-to-speech human interfaces.</p>

    DOI： 10.14326/abe.10.26

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  • Macaques Exhibit Implicit Gaze Bias Anticipating Others' False-Belief-Driven Actions via Medial Prefrontal Cortex. Reviewed International journal

    Taketsugu Hayashi, Ryota Akikawa, Keisuke Kawasaki, Jun Egawa, Takafumi Minamimoto, Kazuto Kobayashi, Shigeki Kato, Yukiko Hori, Yuji Nagai, Atsuhiko Iijima, Toshiyuki Someya, Isao Hasegawa

    Cell reports   30 ( 13 )   4433 - 4444   2020.3

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    The ability to infer others' mental states is essential to social interactions. This ability, critically evaluated by testing whether one attributes false beliefs (FBs) to others, has been considered to be uniquely hominid and to accompany the activation of a distributed brain network. We challenge the taxon specificity of this ability and identify the causal brain locus by introducing an anticipatory-looking FB paradigm combined with chemogenetic neuronal manipulation in macaque monkeys. We find spontaneous gaze bias of macaques implicitly anticipating others' FB-driven actions. Silencing of the medial prefrontal neuronal activity with inhibitory designer receptor exclusively activated by designer drugs (DREADDs) specifically eliminates the implicit gaze bias while leaving the animals' visually guided and memory-guided tracking abilities intact. Thus, neuronal activity in the medial prefrontal cortex could have a causal role in FB-attribution-like behaviors in the primate lineage, emphasizing the importance of probing the neuronal mechanisms underlying theory of mind with relevant macaque animal models.

    DOI： 10.1016/j.celrep.2020.03.013

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  • Deep Learning for Channel-Agnostic Brain Decoding across Multiple Subjects

    Hiroto Date, Keisuke Kawasaki, Isao Hasegawa, Takayuki Okatani

    8th International Winter Conference on Brain-Computer Interface, BCI 2020   2020.2

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    Language：English   Publishing type：Research paper (international conference proceedings)   Publisher：Institute of Electrical and Electronics Engineers Inc.  

    DOI： 10.1109/BCI48061.2020.9061615

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  • マカクザル及びヒトの質的・量的な因果構造理解に基づく自己に関わる出来事の原因帰属行動

    阿部 湧, 足立 雄哉, 田村 滉樹, 齊藤 孝臣, 飯島 淳彦, 長谷川 功

    日本生理学雑誌   82 ( 1 )   11 - 11   2020.2

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    Language：Japanese   Publisher：(一社)日本生理学会  

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  • マカクザルにおける他者の誤信念理解に内側前頭前野が因果的役割を果たす

    秋川 諒太, 林 剛丞, 川嵜 圭祐, 江川 純, 南本 敬史, 小林 和人, 加藤 成樹, 堀 由紀子, 永井 裕司, 飯島 淳彦, 染矢 俊幸, 長谷川 功

    日本生理学雑誌   82 ( 1 )   10 - 10   2020.2

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    Language：Japanese   Publisher：(一社)日本生理学会  

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  • 1文字連続呈示課題を用いた文理解中の2重構造化処理に寄与する神経基盤の解明

    加世堂 竜太郎, 飯島 淳彦, 中原 潔, 足立 雄哉, 長谷川 功

    日本生理学雑誌   82 ( 1 )   12 - 12   2020.2

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    Language：Japanese   Publisher：(一社)日本生理学会  

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  • 硬膜上高密度多点電極を用いたサル一次視覚野における網膜視野の再構成

    土屋 貴大, 飯島 淳彦, 川嵜 圭祐, 鈴木 隆文, 長谷川 功, 中原 潔

    日本生理学雑誌   82 ( 1 )   11 - 12   2020.2

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    Language：Japanese   Publisher：(一社)日本生理学会  

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  • 物体素材に対するサル下側頭葉皮質における皮質脳波応答

    三木 治憲, 安斎 健太, 澤山 正貴, 松尾 健, 鈴木 隆文, 岡谷 貴之, 飯島 淳彦, 長谷川 功, 川嵜 圭祐

    日本生理学雑誌   82 ( 1 )   11 - 11   2020.2

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    Language：Japanese   Publisher：(一社)日本生理学会  

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  • Dissociation between the onset times of convergence eye movements and pupillo-constrictions in the near response of humans Reviewed

    Toda H, Iijima A, Hasegawa I

    J. Clin. Ophthalmol.   3 ( 3 )   174 - 179   2019.12

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  • 自閉スペクトラム症の病態解明に向けた脳磁図による視線認知課題遂行時の脳活動計測

    村松 優希, 杉本 篤言, 吉永 清宏, 山田 千沙, 林 剛丞, 江川 純, 白水 洋史, 飯島 淳彦, 長谷川 功, 染谷 俊幸

    日本小児精神神経学会プログラム・抄録集   122回   56 - 56   2019.11

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    Language：Japanese   Publisher：(一社)日本小児精神神経学会  

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  • マカクザルにおける心の理論の検討および内側前頭前野の不活性化によるその関連性について

    林 剛丞, 江川 純, 川崎 圭祐, 秋川 諒太, 長谷川 功, 飯島 淳彦, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S603 - S603   2019.6

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    Language：Japanese   Publisher：(公社)日本精神神経学会  

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  • Deep Learning for Natural Image Reconstruction from Electrocorticography Signals.

    Hiroto Date, Keisuke Kawasaki, Isao Hasegawa, Takayuki Okatani

    2331 - 2336   2019

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    Publishing type：Research paper (international conference proceedings)  

    DOI： 10.1109/BIBM47256.2019.8983029

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    Other Link： https://dblp.uni-trier.de/db/conf/bibm/bibm2019.html#DateKHO19

  • Locally induced neuronal synchrony precisely propagates to specific cortical areas without rhythm distortion Reviewed

    Haruo Toda, Keisuke Kawasaki, Sho Sato, Masao Horie, Kiyoshi Nakahara, Asim K. Bepari, Hirohito Sawahata, Takafumi Suzuki, Haruo Okado, Hirohide Takebayashi, Isao Hasegawa

    Scientific Reports   8 ( 1 )   7678   2018.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Nature Publishing Group  

    DOI： 10.1038/s41598-018-26054-8

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  • Heterogeneous Redistribution of Facial Subcategory Information Within and Outside the Face-Selective Domain in Primate Inferior Temporal Cortex. Reviewed International journal

    Naohisa Miyakawa, Kei Majima, Hirohito Sawahata, Keisuke Kawasaki, Takeshi Matsuo, Naoki Kotake, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa

    Cerebral cortex (New York, N.Y. : 1991)   28 ( 4 )   1416 - 1431   2018.4

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    The inferior temporal cortex (ITC) contains neurons selective to multiple levels of visual categories. However, the mechanisms by which these neurons collectively construct hierarchical category percepts remain unclear. By comparing decoding accuracy with simultaneously acquired electrocorticogram (ECoG), local field potentials (LFPs), and multi-unit activity in the macaque ITC, we show that low-frequency LFPs/ECoG in the early evoked visual response phase contain sufficient coarse category (e.g., face) information, which is homogeneous and enhanced by spatial summation of up to several millimeters. Late-induced high-frequency LFPs additionally carry spike-coupled finer category (e.g., species, view, and identity of the face) information, which is heterogeneous and reduced by spatial summation. Face-encoding neural activity forms a cluster in similar cortical locations regardless of whether it is defined by early evoked low-frequency signals or late-induced high-gamma signals. By contrast, facial subcategory-encoding activity is distributed, not confined to the face cluster, and dynamically increases its heterogeneity from the early evoked to late-induced phases. These findings support a view that, in contrast to the homogeneous and static coarse category-encoding neural cluster, finer category-encoding clusters are heterogeneously distributed even outside their parent category cluster and dynamically increase heterogeneity along with the local cortical processing in the ITC.

    DOI： 10.1093/cercor/bhx342

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  • Decoding value related signals represented in multiple areas of the prefrontal cortex using ECoG electrodes Reviewed

    Masamichi Sakagami, Shingo Tanaka, Keisuke Kawasaki, Isao Hasegawa, Takafumi Suzuki

    INTERNATIONAL JOURNAL OF PSYCHOLOGY   51   874 - 874   2016.7

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  • Associative-memory representations emerge as shared spatial patterns of theta activity spanning the primate temporal cortex Reviewed

    Kiyoshi Nakahara, Ken Adachi, Keisuke Kawasaki, Takeshi Matsuo, Hirohito Sawahata, Kei Majima, Masaki Takeda, Sayaka Sugiyama, Ryota Nakata, Atsuhiko Iijima, Hisashi Tanigawa, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa

    NATURE COMMUNICATIONS   7   11827   2016.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/ncomms11827

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  • Alternating Zones Selective to Faces and Written Words in the Human Ventral Occipitotemporal Cortex Reviewed

    Takeshi Matsuo, Keisuke Kawasaki, Kensuke Kawai, Kei Majima, Hiroshi Masuda, Hiroatsu Murakami, Naoto Kunii, Yukiyasu Kamitani, Shigeki Kameyama, Nobuhito Saito, Isao Hasegawa

    CEREBRAL CORTEX   25 ( 5 )   1265 - 1277   2015.5

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    DOI： 10.1093/cercor/bht319

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  • Simultaneous electroencephalographic and electrocorticographic measurements of brain activity in a monkey

    Koide, M, Saito, C, Tosaka, T, Hasegawa, I, Hori, J, Iijima, A

    4th Asian Conf. Eng. Edu.   2014.10

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  • Decoding visual object categories from temporal correlations of ECoG signals Reviewed

    Kei Majima, Takeshi Matsuo, Keisuke Kawasaki, Kensuke Kawai, Nokihito Saito, Isao Hasegawa, Yukiyasu Kamitani

    NEUROIMAGE   90   74 - 83   2014.4

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    DOI： 10.1016/j.neuroimage.2013.12.020

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  • Intensive and extensive recording of visual cortical activity by electrocorticography Reviewed

    Isao Hasegawa

    I-PERCEPTION   5 ( 4 )   430 - 430   2014

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  • Super multi-channel recording systems with UWB wireless transmitter for BMI Reviewed

    Takafumi Suzuki, Hiroshi Ando, Takeshi Yoshida, Hirohito Sawahata, Keisuke Kawasaki, Isao Hasegawa, Kojiro Matsushita, Masayuki Hirata, Toshiki Yoshimine, Kenichi Takizawa

    2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)   2014   5208 - 5211   2014

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    Language：English   Publishing type：Research paper (international conference proceedings)  

    DOI： 10.1109/EMBC.2014.6944799

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  • Simultaneous Recording of Single-Neuron Activities and Broad-Area Intracranial Electroencephalography: Electrode Design and Implantation Procedure Reviewed

    Takeshi Matsuo, Kensuke Kawai, Takeshi Uno, Naoto Kunii, Naohisa Miyakawa, Kenichi Usami, Keisuke Kawasaki, Isao Hasegawa, Nobuhito Saito

    NEUROSURGERY   73 ( 2 Suppl Operative )   146 - 154   2013.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1227/01.neu.0000430327.48387.e1

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  • Representation and readout of object information in macaque higher visual cortex Reviewed

    Naohisa Miyakawa, Isao Hasegawa

    Brain and Nerve   65 ( 6 )   643 - 650   2013.6

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

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  • Super Multi-Channel Recording System for BMI

    Suzuki Takafumi, Ando Hiroshi, Yoshida Takeshi, Sawahata Hirohito, Kawasaki Keisuke, Hasegawa Isao, Matsushita Kojiro, Hirata Masayuki, Yoshimine Toshiki, Takizawa Kenichi

    BME   51   M - 2-M-2   2013

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    Language：English   Publisher：Japanese Society for Medical and Biological Engineering  

    DOI： 10.11239/jsmbe.51.M-2

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  • Vergence eye movements signifying 3D depth perception from 2D movies Reviewed

    Atsuhiko Iijima, Seiji Komagata, Tohru Kiryu, Takehiko Bando, Isao Hasegawa

    DISPLAYS   33 ( 2 )   91 - 97   2012.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.displa.2011.11.001

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  • Feature Space Quantization for Data-Driven Search. Reviewed

    Nergis Tomen, Makoto Takemiya, Takeshi Matsuo, Isao Hasegawa, Yukiyasu Kamitani

    Second International Workshop on Pattern Recognition in NeuroImaging, PRNI 2012, London, United Kingdom, July 2-4, 2012   41 - 44   2012

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    Publishing type：Research paper (international conference proceedings)   Publisher：IEEE Computer Society  

    DOI： 10.1109/PRNI.2012.17

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  • Time-frequency domain analyses of the multi-channel electrocorticogram in the primary visual cortex of the hooded rat Reviewed

    Sawahata H, Toda H, Suzuki T, Hasegawa I

    Acta Medica et Biologica   58 ( 2 )   2011.11

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  • LOCAL AND RETROGRADE GENE TRANSFER INTO PRIMATE NEURONAL PATHWAYS VIA ADENO-ASSOCIATED VIRUS SEROTYPE 8 AND 9 Reviewed

    Y. Masamizu, T. Okada, K. Kawasaki, H. Ishibashi, S. Yuasa, S. Takeda, I. Hasegawa, K. Nakahara

    NEUROSCIENCE   193   249 - 258   2011.10

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    DOI： 10.1016/j.neuroscience.2011.06.080

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  • Intrasulcal electrocorticography in macaque monkeys with minimally invasive neurosurgical protocols Reviewed

    Takeshi Matsuo, Keisuke Kawasaki, Takahiro Osada, Hirohito Sawahata, Takafumi Suzuki, Masahiro Shibata, Naohisa Miyakawa, Kiyoshi Nakahara, Atsuhiko Iijima, Noboru Sato, Kensuke Kawai, Nobuhito Saito, Isao Hasegawa

    Frontiers in Systems Neuroscience   5 ( 2011 )   34   2011.5

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    DOI： 10.3389/fnsys.2011.00034

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  • Simultaneous recording of ECoG and intracortical neuronal activity using a flexible multichannel electrode-mesh in visual cortex Reviewed

    Haruo Toda, Takafumi Suzuki, Hirohito Sawahata, Kei Majima, Yukiyasu Kamitani, Isao Hasegawa

    NEUROIMAGE   54 ( 1 )   203 - 212   2011.1

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    DOI： 10.1016/j.neuroimage.2010.08.003

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  • Composition of double-articulated symbols for categorizing objects in macaque monkeys Reviewed

    Atsuhiko Iijima, Yuuya Hatano, Nobuyoshi Fujisawa, Isao Hasegawa

    NEUROSCIENCE RESEARCH   71   E390 - E390   2011

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  • 3D映像視聴と自律神経 Reviewed

    飯島淳彦, 小杉剛, 木竜徹, 長谷川功, 板東武彦

    自律神経   49 ( 3 )   208 - 210   2011

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  • Evaluation of Stressed Condition using Pupillary Responses Reviewed

    IIJIMA Atsuhiko, KOSUGI Takeshi, KIRYU Tohru, MATSUKI Kosuke, HASEGAWA Isao, BANDO Takehiko

    BME   49 ( 6 )   946 - 951   2011

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    We investigated an effective method for evaluating chronic stress in humans by using pupillary responses to visual motion stimuli. Nine subjects watched movies including 18 short video movies (duration:10s in each). The pupil diameter responding to the movies were measured with a video oculography and calculated the difference between the maximum and minimum pupil diameters responded to the stimuli was highly correlated with the salivary α-amylase (R=-0.76, <i>p</i>=0.018) activities. The sympathetic nervous system is activated by a stress and secretes the salivary amylase. We found that there were some autonomic different responses in the stress subject from pupillary and salivary observations. These phenomena were clearly observed under the visual movie stimulation which was able to reveal the steady pupillary responses.

    DOI： 10.11239/jsmbe.49.946

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  • Category decoding from macaque anterior inferotemporal cortex with simultaneous electrocorticogram and multi-channel unit recording Reviewed

    Naohisa Miyakawa, Kei Majima, Hirohito Sawahata, Keisuke Kawasaki, Takeshi Matsuo, Naoki Kotake, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa

    NEUROSCIENCE RESEARCH   71   E256 - E256   2011

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  • P2-u04 Electrocorticographically distinguished multiple visual/auditory areas in rat temporal cortex with MEMS-based flexible electrode-meshes Reviewed

    Haruo Toda, Hirohito Sawahata, Takafumi Suzuki, Naoki Kotake, Masao Horie, Isao Hasegawa

    NEUROSCIENCE RESEARCH   71   E204 - E204   2011

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  • Estimation of the intracortical LFPs from microECoGs based on spontaneous neuronal activities Reviewed

    Tomoya Sakatani, Hidenori Watanabe, Yukio Nishimura, Atsushi Nambu, Isao Hasegawa, Takafumi Suzuki, Masa-aki Sato, Mitsuo Kawato, Tadashi Isa

    NEUROSCIENCE RESEARCH   71   E203 - E203   2011

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  • Intrasulcal ECoG approach to cortico-cortical connectivity using electrical stimulation-induced evoked potentials in macaques Reviewed

    Takahiro Osada, Antoine J. Molcard, Takeshi Matsuo, Keisuke Kawasaki, Yusuke Adachi, Kentaro Miyamoto, Tomomi Watanabe, Isao Hasegawa, Yasushi Miyashita

    NEUROSCIENCE RESEARCH   71   E97 - E97   2011

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  • Intrasulcal electrocorticography in macaque monkeys Reviewed

    Keisuke Kawasaki, Takeshi Matsuo, Takahiro Osada, Hirohito Sawahata, Takafumi Suzuki, Masahiro Shibata, Naohisa Miyakawa, Kiyoshi Nakahara, Noboru Sato, Kensuke Kawai, Nobuhito Saito, Isao Hasegawa

    NEUROSCIENCE RESEARCH   71   E413 - E414   2011

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  • マカクザルによる物体カテゴリーの象徴化(Symbolization of object categories by macaque monkeys)

    飯島 淳彦, 畠野 雄也, 藤澤 信義, 長谷川 功

    神経化学   49 ( 2-3 )   572 - 572   2010.8

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  • MEMS技術によるメッシュ型フレキシブル電極の開発と記録性能(Recording quality of a MEMS-based flexible electrode-mesh in vivo)

    澤畑 博人, 鈴木 隆文, 小竹 直樹, 間島 慶, 神谷 之康, 戸田 春男, 長谷川 功

    神経化学   49 ( 2-3 )   683 - 683   2010.8

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  • サル一次運動野における皮質内局所電位とECoG信号による前腕到達把持運動軌道の推定(Regression of forearm reach and grasp movement trajectories using intracortical local field potentials and electrocorticogram signals in monkey primary motor cortex)

    渡辺 秀典, 山下 宙人, 澤畑 博人, 坂谷 智也, 戸川 森雄, 吉田 正俊, 戸田 春男, 佐藤 雅昭, 長谷川 功, 鈴木 隆文, 川人 光男, 伊佐 正

    神経化学   49 ( 2-3 )   497 - 497   2010.8

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  • Regional cerebral blood flow in patients with orally localized somatoform pain disorder: a single photon emission computed tomography study Reviewed

    Hiroyuki Karibe, Ryosuke Arakawa, Amane Tateno, Sunao Mizumura, Tomoo Okada, Takashi Ishii, Katsuo Oshima, Mitsuhiro Ohtsu, Isao Hasegawa, Yoshiro Okubo

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   64 ( 5 )   476 - 482   2010

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    DOI： 10.1111/j.1440-1819.2010.02119.x

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  • Recording quality of a MEMS-based flexible electrode-mesh in vivo Reviewed

    Hirohito Sawahata, Takafumi Suzuki, Naoki Kotake, Kei Majima, Yukiyasu Kamitani, Haruo Toda, Isao Hasegawa

    NEUROSCIENCE RESEARCH   68   E326 - E326   2010

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  • Gene transfer into the primate central nervous system via antero- and retrograde infections by adeno-associated viruses Reviewed

    Yoshito Masamizu, Takashi Okada, Keisuke Kawasaki, Hidetoshi Ishibashi, Shin'ichi Takeda, Shigeki Yuasa, Isao Hasegawa, Kiyoshi Nakahara

    NEUROSCIENCE RESEARCH   68   E219 - E219   2010

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  • Symbolization of object categories by macaque monkeys Reviewed

    Atsuhiko Iijima, Yuya Hatano, Nobuyoshi Fujisawa, Isao Hasegawa

    NEUROSCIENCE RESEARCH   68   E180 - E180   2010

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  • Neural decoding of visual object categories using temporal patterns of ECoG signals Reviewed

    Kei Majima, Takeshi Matsuo, Keisuke Kawasaki, Kensuke Kawai, Hiroshi Masuda, Naoto Kunii, Hiroatsu Murakami, Kyousuke Kamada, Shigeki Kameyama, Nobuhito Saito, Isao Hasegawa, Yukiyasu Kamitani

    NEUROSCIENCE RESEARCH   68   E381 - E382   2010

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  • Estimation of the intracortical neuronal dynamics from the multi-channel ECoG signals Reviewed

    Tomoya Sakatani, Hidenori Watanabe, Morio Togawa, Masatoshi Yoshida, Isao Hasegawa, Takafumi Suzuki, Masa-aki Sato, Mitsuo Kawato, Tadashi Isa

    NEUROSCIENCE RESEARCH   68   E326 - E326   2010

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  • Regression of forearm reach and grasp movement trajectories using intracortical local field potentials and electrocorticogram signals in monkey primary motor cortex Reviewed

    Hidenori Watanabe, Okito Yamashita, Hirohito Sawahata, Tomoya Sakatani, Morio Togawa, Masatoshi Yashida, Haruo Toda, Masa-aki Sato, Isao Hasegawa, Takafumi Suzuki, Mitsuo Kawato, Tadashi Isa

    NEUROSCIENCE RESEARCH   68   E83 - E83   2010

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  • Electrocorticographic mapping of human ventral visual areas Reviewed

    Takeshi Matsuo, Keisuke Kawasaki, Kensuke Kawai, Hiroshi Masuda, Naoto Kunii, Hiroatu Murakami, Kei Majima, Kyousuke Kamada, Yukiyasu Kamitani, Shigeki Kameyama, Nobuhito Saito, Isao Hasegawa

    NEUROSCIENCE RESEARCH   68   E99 - E99   2010

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  • Simultaneous recording of high-density electrocorticogram and intracortical activity using MEMS-fabricated electrode array Reviewed

    Haruo Toda, Hirohito Sawahata, Takafumi Suzuki, Kei Majima, Yukiyasu Kamitani, Isao Hasegawa

    JOURNAL OF PHYSIOLOGICAL SCIENCES   60   S204 - S204   2010

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  • PUPILLARY LIGHT REFLEXES TO COLOR STIMULI IN RATS USING A NEWLY DEVELOPED VIDEO PUPILOMETER WITH A DIFFUSE ILLUMINATION SYSTEM Reviewed

    Atsuhiko Iijima, Munetaka Haida, Shigehisa Iida, Shigeaki Sonoda, Isao Hasegawa

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59   200 - 200   2009

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  • Multi-channel recording of the electrocorticogram in anesthetized rats with parylene electrode arrays Reviewed

    Hidenori Watanabe, Tomoya Sakatani, Morio Togawa, Masatoshi Yoshida, Tadashi Isa, Isao Hasegawa, Takafumi Suzuki

    NEUROSCIENCE RESEARCH   65   S181 - S181   2009

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  • Mesh electrode arrays applied to record visual cortical activities in hooded rats Reviewed

    Hirohito Sawahata, Haruo Toda, Takafumi Suzuki, Isao Hasegawa

    NEUROSCIENCE RESEARCH   65   S60 - S61   2009

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  • Cerebral blood flow and autonomic responses during visually induced motion sickness Reviewed

    Atsuhiko Iijima, Kazuhiko Ukai, Tohru Kiryu, Haruo Toda, Isao Hasegawa, Takehiko Bando

    NEUROSCIENCE RESEARCH   61   S176 - S176   2008

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  • Long-term remission of cyclic Cushing's disease that was diagnosed and treated surgically in non-active phase Reviewed

    Shuichiro Asano, Hikaru Ooka, Ryo Okazakf, Toshio Fshlkawa, HiRomi Ochiai, Michi Nakashima, Fuyuaki Ide, Isao Hasegawa, Satoru Miyawaki, Hiroshi Nakaguchf, Mineko Murakamf, Yoshio Ogino, Koji Takano, Akira Matsu-No

    ENDOCRINE JOURNAL   54 ( 3 )   407 - 412   2007.6

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    DOI： 10.1507/endocrj.K06-218

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  • Prefrontal neuronal activity encodes spatial target representations sequentially updated after nonspatial target-shift cues Reviewed

    T Fukushima, Hasegawa, I, Y Miyashita

    JOURNAL OF NEUROPHYSIOLOGY   91 ( 3 )   1367 - 1380   2004.3

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    DOI： 10.1152/jn.00306.2003

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  • Functional magnetic resonance imaging of macaque monkeys performing visually guided saccade tasks: Comparison of cortical eye fields with humans Reviewed

    M Koyama, Hasegawa, I, T Osada, Y Adachi, K Nakahara, Y Miyashita

    NEURON   41 ( 5 )   795 - 807   2004.3

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    DOI： 10.1016/S0896-6273(04)00047-9

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  • Categorizing the world: expert neurons look into key features Reviewed

    Hasegawa, I, Y Miyashita

    NATURE NEUROSCIENCE   5 ( 2 )   90 - 91   2002.2

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  • Neural mechanisms of memory retrieval: Role of the prefrontal cortex Reviewed

    Hasegawa, I

    REVIEWS IN THE NEUROSCIENCES   11 ( 2-3 )   113 - 125   2000

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  • Memory retrieval under the control of the prefrontal cortex Reviewed

    Hasegawa, I, T Hayashi, Y Miyashita

    ANNALS OF MEDICINE   31 ( 6 )   380 - 387   1999.12

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  • Top-down signal from prefrontal cortex in executive control of memory retrieval Reviewed

    H Tomita, M Ohbayashi, K Nakahara, Hasegawa, I, Y Miyashita

    NATURE   401 ( 6754 )   699 - 703   1999.10

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    DOI： 10.1038/44372

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  • Mapping of somatosensory cortices with functional magnetic resonance imaging in anaesthetized macaque monkeys Reviewed

    HAYASHI T, KONISHI S, HASEGAWA I

    EUROPEAN JOURNAL OF NEUROSCIENCE   11 ( 12 )   4451 - 4456   1999

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1046/j.1460-9568.1999.00892.x

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  • Callosal window between prefrontal cortices: Cognitive interaction to retrieve long-term memory Reviewed

    Hasegawa, I, T Fukushima, T Ihara, Y Miyashita

    SCIENCE   281 ( 5378 )   814 - 818   1998.8

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    DOI： 10.1126/science.281.5378.814

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  • Consolidation of visual associative long-term memory in the temporal cortex of primates Reviewed

    Y Miyashita, M Kameyama, Hasegawa, I, L Fukushima

    NEUROBIOLOGY OF LEARNING AND MEMORY   70 ( 1-2 )   197 - 211   1998.7

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    DOI： 10.1006/nlme.1998.3848

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  • Neural organization of memory Reviewed

    Hasegawa, I, Y Miyashita

    JAPANESE JOURNAL OF NEUROPSYCHOPHARMACOLOGY   19 ( 12 )   1103 - 1109   1997.12

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  • 皮質脳波（ECoG）法とfMRIによるサル・ヒトの前頭葉・側頭葉の神経生理学的検証

    飯島 淳彦, 劉 南希, 加世堂 竜太郎, 渡辺 卓爾, 中野 広輝, 松尾 健, 川嵜 圭祐, 足立 雄哉, 田中 慎吾, 中原 潔, 長谷川 功

    生体医工学   Annual60 ( Abstract )   111_1 - 111_1   2022

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    Language：Japanese   Publisher：公益社団法人 日本生体医工学会  

    本研究では，ヒトおよびマカクザル（ニホンザル）の前頭葉と側頭葉に留置した皮質脳波（ECoG）電極から記録した神経活動と，ヒトを対象としたfMRIの脳機能画像を用いて，高次機能に関連した神経回路の検証を行なっている．特に，言語機能に関わる脳領域の推定と各領域の連関，視覚的な認知に寄与する神経ネットワークについての研究成果を報告する．

    DOI： 10.11239/jsmbe.annual60.111_1

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  • マカクザルを用いた心の理論の脳基盤研究

    林 剛丞, 江川 純, 川嵜 圭祐, 秋川 諒太, 長谷川 功, 飯島 敦彦, 染矢 俊幸

    新潟医学会雑誌   135 ( 7 )   139 - 139   2021.7

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  • マカクザルにおける心の理論の検討および内側前頭前野の不活性化によるその関連性について

    林 剛丞, 江川 純, 川崎 圭祐, 秋川 諒太, 長谷川 功, 飯島 淳彦, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S603 - S603   2019.6

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  • 皮質脳波法による視覚・記憶の脳情報解読

    長谷川 功

    日本生理学雑誌   80 ( 1 )   6 - 6   2018.2

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  • Neural mechanisms of visual imagery-beyond the classical functional localization theory

    長谷川功

    神経心理学   34 ( 3 )   184‐189(J‐STAGE)   2018

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  • 【ブレインマシンインターフェース】 視覚系のブレインデコーディング 皮質脳波(ECoG)信号を用いた脳内イメージ情報のデコーディング

    谷川 久, 武井 廉, 長谷川 功

    Clinical Neuroscience   34 ( 2 )   193 - 196   2016.2

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  • Decoding recalled color imagery using ECoG signals in macaque inferior temporal and prefrontal cortices

    TANIGAWA Hisashi, TAKEI Ren, MAJIMA Kei, KAWASAKI Keisuke, SAWAHATA Hiroto, NAKAHARA Kiyoshi, SUZUKI Takafumi, KAMIYA Yukiyasu, HASEGAWA Isao

    日本神経回路学会全国大会講演論文集   25th   103   2015.9

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  • Development of ECoG based multi-channel recording BMI system using UWB wireless communications

    ANDO Hiroshi, TAKIZAWA Kenichi, YOSHIDA Takeshi, SAWAHATA Hirohito, KAWASAKI Keisuke, HASEGAWA Isao, MATSUSHITA Kojiro, HIRATA Masayuki, YOSHIMINE Toshiki, SUZUKI Takafumi

    日本生体医工学会大会プログラム・論文集(CD-ROM)   53rd   ROMBUNNO.SY3-03-6   2014

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  • 皮質脳波法による脳情報の計測

    長谷川 功

    電子情報通信学会技術研究報告(MEとバイオサイバネティックス)   113 ( 222 )   73 - 75   2013.9

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  • Representation and Readout of Object Information in Macaque Higher Visual Cortex

    宮川尚久, 長谷川功

    Brain Nerve   65 ( 6 )   643 - 650   2013.6

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  • 皮質脳波による大脳視覚イメージの復号化

    長谷川 功

    新潟医学会雑誌   127 ( 3 )   127 - 132   2013.3

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  • 次世代のてんかん発作モニタリング,脳機能評価を目指して

    松尾健, 川合謙介, 宇野健志, 國井尚人, 川嵜圭祐, 宮川尚久, 長谷川功, 斉藤延人

    日本てんかん外科学会プログラム・抄録集   36th   50   2012.12

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  • 皮質脳波法による視覚情報の解読

    長谷川功

    Jpn J Rehabil Med   49 ( 10 )   720 - 725   2012.10

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  • Brain-Machine Interface(BMI)でImpairmentに切り込む 皮質脳波法による視覚情報の解読

    長谷川 功

    The Japanese Journal of Rehabilitation Medicine   49 ( 10 )   720 - 725   2012.10

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  • サル下側頭葉皮質の動きの処理について

    中島 啓, 川嵜 圭祐, 澤畑 博人, 鈴木 隆文, 長谷川 功

    Vision   24 ( 3 )   119 - 119   2012.7

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  • Articulation of bigram symbols and generalization of object categories in Macaque monkeys

    IIJIMA Atsuhiko, IWATA Yutaka, HATANO Yuuya, FUJISAWA Nobuyoshi, HASEGAWA Isao

    Primate Research Supplement   28 ( 0 )   81 - 81   2012

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    目的&lt;br&gt;ニホンザルにおいて2要素の組み合わせからなる複合図形と物体との関係を学習させ，それに基づいて複合図形の分解ができるかを調査した．また，物体のカテゴリー化を要素図形による複合図形の組み立てタスクによって回答できるかについても調査した．&lt;br&gt;&lt;br&gt;方法&lt;br&gt;2頭のニホンザル（&lt;i&gt;Macaca fuscata&lt;/i&gt;）に6組の複合図形と物体との関係を学習させた（Paired Association Training：PA）．複合図形は物体とは無関係の6つの要素図形の中の2つで構成した．PAを十分に学習したのち，物体をcueとして呈示し，choiceで複合図形そのものではなく要素図形を4つ呈示し，正しい2つを選択させるテストを行った（Articulation Test：AT）．更に，6組の複合図形－物体に対して，物体と同一カテゴリーの図形を順次加え，一組に7種類の図形を用いてカテゴリーを形成し，そのカテゴリーが汎化するかを，probe test としてtrial unique刺激を用いてATで検証した．&lt;br&gt;結果&lt;br&gt;PAを十分に学習した後のATのfirst trialは，2頭の平均正答率が62.3%で，16.7%のchance levelに比べて有意に正答を示した．また，trial unique刺激を用いてカテゴリーの汎化力を調べた結果，Probe trial（p =3.2*10^-15, binominal test），Prototype trial（p =1.6*10^-14）でともにchance levelの16.7%を有意に上回る成績だった．&lt;br&gt;考察・結論ニホンザルにおいて，基本セットの学習を行えば，それをもとに要素図形から複合図形を構成できることが分かった．これはcueとして与えられた物体画像を見ることが，対応する複合図形を見なくてもそれを想起させ，そのイメージを基に複合図形を構成したと考えられる．カテゴリーの汎化と合わせて，個々には意味を持たない図形要素の組み合わせから，意味のある図形を作り出す能力がニホンザルに存在すると考えられる．

    DOI： 10.14907/primate.28.0_81

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  • BMIでImpairmentに切り込む 皮質脳波法による視覚認知情報の解読とBrain-machine interfaceへの応用

    長谷川 功

    The Japanese Journal of Rehabilitation Medicine   48 ( Suppl. )   S156 - S156   2011.10

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  • ここまで進んだ日本のブレイン・マシン・インタフェース(BMI)研究 大脳視覚連合野の皮質脳波から物体視の脳情報を読み解くBMI

    長谷川 功

    臨床神経生理学   39 ( 5 )   337 - 337   2011.10

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    Language：Japanese   Publisher：(一社)日本臨床神経生理学会  

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  • てんかん術前モニタリングにおける単一ニューロン記録電極の開発と皮質脳波同時記録の試み

    川合 謙介, 松尾 健, 宇佐美 憲一, 國井 尚人, 宮川 尚久, 長谷川 功, 齊藤 延人

    てんかん研究   29 ( 2 )   335 - 335   2011.9

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  • The Effect of Viewing 3D Images on Autonomic Nervous System

    IIJIMA Atsukiko, KOSUGI Takeshi, KIRYU Tohru, HASEGAWA Isao, BANDO Takehiko

    The Autonomic nervous system   48 ( 3 )   208 - 210   2011.6

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  • 皮質脳波を用いた側頭葉視覚領野の機能マッピング(Electrocorticographic mapping of human ventral visual areas)

    松尾 健, 川嵜 圭祐, 川合 謙介, 増田 浩, 國井 尚人, 村上 博淳, 間島 慶, 鎌田 恭輔, 神谷 之康, 亀山 茂樹, 齋藤 延人, 長谷川 功

    神経化学   49 ( 2-3 )   508 - 508   2010.8

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    Language：English   Publisher：日本神経化学会  

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  • 皮質脳波の時間的パターンを用いた視覚物体カテゴリーのデコーディング(Neural decoding of visual object categories using temporal patterns of ECoG signals)

    間島 慶, 松尾 健, 川嵜 圭祐, 川合 謙介, 増田 浩, 國井 尚人, 村上 博淳, 鎌田 恭輔, 亀山 茂樹, 斉藤 延人, 長谷川 功, 神谷 之康

    神経化学   49 ( 2-3 )   724 - 724   2010.8

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  • 頭部固定の有無がビデオ方式による視線位置計測に与える影響

    木竜 雄一郎, 飯島 淳彦, 川嵜 圭祐, 宮川 尚久, 前田 義信, 長谷川 功

    電子情報通信学会技術研究報告(MEとバイオサイバネティックス)   109 ( 194 )   19 - 22   2009.9

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    Language：Japanese   Publisher：社団法人電子情報通信学会  

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  • Neural correlates of visual choices in the rat visual association cortex

    Reports of Toyoda Physical and Chemical Research Institute.   ( 62 )   191 - 195   2009.5

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  • Cerebral organization for retention and activation of long-term memory

    Niigata medical journal   122 ( 12 )   663 - 668   2008.12

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  • 視覚性運動の認知に伴う瞳孔反応と輻輳眼球運動の関係

    飯島 淳彦, 鵜飼 一彦, 辻村 誠一, 鳥居 正人, 平本 翔太, 長谷川 功, 板東 武彦

    神経眼科   25 ( 増補1 )   100 - 100   2008.10

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    Language：Japanese   Publisher：日本神経眼科学会  

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  • 先端巨大症に対するoctreotide療法 GH産生下垂体腺腫におけるオクトレオチドによるGHの低下率に関与する因子に関する多変量解析

    松野彰, 中島美智, 高野幸路, 高野順子, 水谷晃子, 長村義之, 竹井麻生, 田原重志, 寺本明, 山田正俊, 山崎一人, 石田康生, 宮脇哲, 井出冬章, 田中純一, 浅野修一郎, 長谷川功, 中口博, 村上峰子

    ホルモンと臨床   56 ( 冬季増刊 )   46 - 50   2008.2

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    J-GLOBAL

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  • 術中運動誘発電位モニタによる安全な手術

    浅野修一郎, 鈴木一郎, 森田明夫, 川原信隆, 中込忠好, 藤巻高光, 古屋一英, 原徹男, 羽井佐利彦, 宮脇哲, 長谷川功, 中口博, 田中純一, 村上峰子, 松野彰

    日本脳神経外科学会総会抄録集(CD-ROM)   66th   2K-P18-2-10 - P18   2007.10

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    Language：Japanese   Publisher：(一社)日本脳神経外科学会  

    J-GLOBAL

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  • P1-22 痙攣発作にて救急入院が必要であった症例の傾向 : 当院2006年の経験(病因2,一般演題(ポスター),てんかん制圧:新たなステージに向けて,第41回日本てんかん学会)

    浅野修一郎, 宮脇哲, 長谷川功, 中口博, 村上峰子, 松野彰

    てんかん研究   25 ( 3 )   2007.9

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    Publisher：日本てんかん学会  

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  • GHRH‐GH同時産生下垂体腺腫に対する,オクトレオチドLARとカベルゴリンによる併用療法の効用

    松野彰, 片上秀喜, 中島美智, 井出冬章, 宮脇哲, 浅野修一郎, 長谷川功, 中口博, 村上峰子, 寺本明, 長村義之

    日本間脳下垂体腫よう学会プログラム・抄録集   17th   79   2007

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    J-GLOBAL

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  • GH産生下垂体腺腫におけるオクトレオチドによるGHの低下率は何に相関するか

    中島美智, 水谷晃子, 竹井麻生, 高野幸路, 長村義之, 寺本明, 宮脇哲, 浅野修一郎, 長谷川功, 中口博, 村上峰子, 松野彰

    日本間脳下垂体腫よう学会プログラム・抄録集   17th   91   2007

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    J-GLOBAL

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  • GH産生下垂体腺腫におけるoctreotideに対する反応性に関するKi‐67,gsp mutation,SSTRの多変量解析

    松野彰, 中島美智, 水谷晃子, 長村義之, 高野幸路, 高野順子, 竹井麻生, 田原重志, 寺本明, 井出冬章, 宮脇哲, 浅野修一郎, 長谷川功, 田中純一, 中口博, 村上峰子

    日本脳神経外科学会総会抄録集(CD-ROM)   66th   3K-P50-1-6   2007

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    J-GLOBAL

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  • 運動誘発電位モニタリングによる手術支援

    浅野修一郎, 鈴木一郎, 森田明夫, 川原信隆, 原徹男, 羽井佐利彦, 中込忠好, 村上秀喜, 宮脇哲, 中島美智, 長谷川功, 中口博, 松野彰

    日本脳神経外科学会総会抄録集(CD-ROM)   65th   1P-046   2006

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    J-GLOBAL

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  • サル前頭前野の反応抑制活動のマッピング 事象関連機能的磁気共鳴画像法を用いた計測

    森田 将史, 林 俊宏, 中原 潔, 小山 実, 長谷川 功, 宮下 保司

    神経化学   40 ( 2-3 )   327 - 327   2001.9

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    Language：Japanese   Publisher：日本神経化学会  

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  • Event-related functional magnetic resonance imaging in awake macaque monkey performing oculomotor tasks. Reviewed

    Hasegawa, I, Koyama, M, Nakahara, K, Morita, M, Hayashi, T, Fukushima, Y, Miyashita, Y

    Society for Neuroscience Abstract   27   345.12   2001

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  • An event-related fMRI study of go/no-go task in macaque monkeys. Reviewed

    Morita, M, Hayashi, T, Nakahara, K, Koyama, M, Hasegawa, I, Miyashita, Y

    Society for Neuroscience Abstract   27   345.11   2001

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  • Nogo dominant activity in monkey prefrontal cortex: an event-related fMRI study. Reviewed

    Morita, M, Hayashi, T, Nakahara, K, Koyama, M, Hasegawa, I, Miyashita, Y

    Neuroscience Research   25   S97   2001

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  • マカク猿における機能的磁気共鳴撮像による体性感覚皮質のマッピング

    Hayashi Toshihiro, Konishi Seiki, Hasegawa Isao, Miyashita Yasushi

    Neuroscience Research   ( Suppl.23 )   S296 - S296   1999.7

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    Language：English   Publisher：エルゼビア・ジャパン(株)  

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  • Interhemispheric transfer between prefrontal cortices: cognitive interaction for retrieval of long-term memory.

    Hasegawa, I, Fukushima, T, Ihara, T, Hayashi, T, Miyashita, Y

    Society for Neuroscience Abstract   24   1688   1998

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Presentations

  • fMRIを用いた文字から文への構造化プロセスに関わる脳領域の探索

    渡邊諒太, 飯島淳彦, 中原潔, 白水洋史, 福多真央, 足立雄哉, 長谷川功

    生体医工学シンポジウム2018  2018.9 

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  • 自己に関わる出来事の原因判断行動を検出するマカクザル実験パラダイム

    田村滉樹, 足立雄哉, 阿部湧, 飯島淳彦, 長谷川功

    生体医工学シンポジウム2018  2018.9 

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  • Time-frequency representation of the responses for animate and inanimate objects in inferior temporal and medial dorsal prefrontal cortex

    Naohiro Okita, Keisuke Kawasaki, Yoshimichi Takahashi, Takeshi Matsuo, Takafumi Suzuki, Isao Hasegawa

    2018.7 

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  • Anticipating of other's behavior on the basis of understanding other's false beliefs in rhesus monkeys (Macaca fuscata)

    Taketsugu Hayashi, Keisuke Kawasaki, Ryota Akikawa, Isao Hasegawa, Jun Egawa, Toshiyuki Someya, Atsuhiko Iijima

    2018.7 

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  • Neural activity during spelling the names of objects in the macaque prefrontal cortex

    Nanxi Liu, Kento Ohashi, Keisuke Kawasaki, Takafumi Suzuki, Takeshi Matsuo, Atsuhiko Iijima, Isao Hasegawa

    2018.7 

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  • 医工連携による高密度皮質脳波の可能性―基礎実験での検証

    松尾健, 川嵜圭佑, 鈴木隆文, 長谷川功

    日本てんかん外科学会プログラム・抄録集  2018 

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  • Elucidating the role of the macaque lateral prefrontal cortex for the value-based decision making using the decoded neurofeeback

    Tanaka S, Kawasaki K, Hasegawa I, Suzuki T, Kawato M, Sakagami M

    Real-time functional imaging and neurofeedback conference 2017  2017.11 

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  • Spatial and temporal distribution of the value and the visual stimulus related information in the macaque lateral prefrontal cortex

    Tanaka S, Kawasaki K, Hasegawa I, Suzuki T, Kawato M, Sakagami M

    Neuroscience2017  2017.11 

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  • イメージを生む脳回路のはたらき―機能局在論を超えて Invited

    長谷川功

    第41回日本神経心理学会  2017.10 

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  • 皮質脳波法による視覚・記憶の脳情報解読 Invited

    長谷川功

    第64回中部生理学会  2017.10 

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  • fMRIによる逐語的な文の階層構造構築過程における脳内機構の解明

    岡本俊輔, 渡邊諒太, 飯島淳彦, 中原潔, 足立雄哉, 長谷川功

    生体医工学シンポジウム2017  2017.9 

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  • イメージを生む脳回路のはたらき―機能局在論を超えて

    長谷川功

    日本神経心理学会総会プログラム・予稿集  2017.9 

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  • Distribution of value related information in the multiple areas of the macaque prefrontal cortex

    Tanaka S, Kawasaki K, Hasegawa I, Suzuki T, Kawato M, Sakagami M

    2017.7 

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  • Category information in prefrontal and inferior temporal cortex for animate or inanimate categorization in macaques

    Takahashi Y, Kawasaki K, Hongo T, Kulasekara M, Suzuki T, Iijima A, Matsuo T, Teramoto T, Hasegawa I

    2017.7 

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  • 脳外科医の視点から紐解く脳のネットワーク

    長谷川功

    第57回春秋コングレス  2016.12 

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  • Relationships between the internal representations of convolutional neural network and the space, time and frequency domains of ECoG signals on macaque inferior temporal cortex

    Date H, Kawasaki K, Ozay M, Hongo T, Hasegawa I, Okatani T

    Neuroscience2016  2016.11 

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  • Modulation of value information coded in the lateral prefrontal cortex by decode neurofeedback with electrocorticographic (ECoG) signals

    Tanaka S, Kawasaki K, Hasegawa I, Suzuki T, Sakagami M

    Neuroscience2016,  2016.11 

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  • Decoding recalled color imagery using ECoG signals in macaque inferior temporal and prefrontal cortices

    Tanigawa H, Majima K, Takei R, Kawasaki K, Sawahata H, Nakahara K, Suzuki T, Kamitani Y, Hasegawa I

    Neuroscience2016,  2016.11 

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  • Dcording value related signals represented in multiple areas of the prefrontal cortex using ECoG electrodes

    Tanaka S, Kawasaki K, Hasegawa I, Suzuki T

    The 31st international congress of psychology 2016  2016.7 

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  • Learninng to signify objects by construction of visual double-articulated signs from elements in macaque monkeys(Macaca Fuscata).

    Ohashi K, Iijima A, Miyajima T, Iwata Y, Hasegawa I

    2016.7 

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  • Decoding the value related information from the ECoG signal recorded from the multiple areas of the prefrontal cortex

    Tanaka S, Kawasaki K, Hasegawa I, Suzuki T, Sakagami M

    2016.7 

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  • Directional influences through theta band activity between macaque inferior temporal and prefrontal cortices during memory retrieval

    Sasaki H, Tanigawa H, Kawasaki K, Iijima A, Suzuki T

    2016.7 

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  • Correspondence between the representations of convolutional neural networks and the activities in inferior temporal cortex measured by electrocorticography

    Date H, Kawasaki K, Ozay M, Hongo T, Hasegawa I, Okatani T

    2016.7 

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  • Direction-specific spectral shift of local field potentials in the rat visual cortics found by a combination of electrocorticogram and optogenetics

    Toda H, Kawasaki K, Horie M, Nakahara K, Bepari K Asim, Sawahata H, Suzuki T, Takebayasi H, Hasegawa I

    2016.7 

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  • Mismatch negativity in macaque auditory cortex is composed of several components of auditory stimuli

    Suda Y, Tada M, Matsuo T, Kawasaki K, Suzuki T, Hasegawa I, Matsumoto K, Kasai K, Uka T

    2016.7 

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  • 皮質脳波法による脳情報の計測

    長谷川 功

    電子情報通信学会技術研究報告(MEとバイオサイバネティックス)  2013.9 

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    Language：Japanese  

    わたしたちは脳の表面に「網をかける」ように張りめぐらせて局所フィールド電位を多点記録する柔軟なメッシュ型の皮質脳波電極を設計し、さらにラットやマカクザルの動物モデルで、微小電極法との比較において、高密度のメッシュ型電極によって得られる信号の記録特性を検証する系を開発しました。マカクザルでは、メッシュ型電極を脳表のみならず脳溝に広範囲留置することも可能となりました。これらの手法を用いてマカクザル下側頭葉の神経活動を計測し、視覚刺激のカテゴリーを解読する技術が、次世代の脳と機械のインターフェイス(ブレイン・マシン・インターフェイス)の構築につながることが期待されます。(著者抄録)

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Industrial property rights

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Research Projects

  • 電場電位の位相構築マップから読み解く霊長類大脳連合野の構造-機能連関

    Grant number：23H00413

    2023.4 - 2027.3

    System name：科学研究費助成事業

    Research category：基盤研究(A)

    Awarding organization：日本学術振興会

    長谷川 功, 松尾 健, 鈴木 隆文, 林 拓也, 中原 潔, 南本 敬史, 竹林 浩秀

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    Grant amount：\46670000 （ Direct Cost: \35900000 、 Indirect Cost：\10770000 ）

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  • 言語の構造化に関わる抑制性脳回路仮説の多元的検証

    Grant number：21454250

    2021.8 - 2024.3

    System name：脳とこころの研究推進プログラム（領域横断的かつ萌芽的脳研究プロジェクト）

    Research category：1A 境界領域から生まれる脳科学に資する研究開発（神経回路～行動)

    Awarding organization：日本医療研究開発機構

    飯島淳彦, 林拓也, 松尾健

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    Authorship：Principal investigator 

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  • 非侵襲的かつ脳深部へ適応可能な新規刺激法を用いたヒト記憶脳回路の解明

    Grant number：21K18267

    2021.7 - 2025.3

    System name：科学研究費助成事業

    Research category：挑戦的研究(開拓)

    Awarding organization：日本学術振興会

    竹田 真己, 中原 潔, 長谷川 功, 地村 弘二, 渡邊 言也

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    Grant amount：\26000000 （ Direct Cost: \20000000 、 Indirect Cost：\6000000 ）

    経頭蓋集束超音波刺激を用いて、深部脳活動をコントロールした際の記憶パフォーマンスを検証することで、ヒトにおける記憶脳回路の因果的役割を解明する。（１）脳深部の内因性脳活動の位相にあわせた刺激が可能か、（２）刺激の効果範囲を十分に限定できるか、といった技術的課題をクリアするために、サルを対象に、経頭蓋集束超音波刺激の効果を経頭蓋と頭蓋内の両方の脳活動を同時計測して比較することにより検証する。本年度はヒトを被験者として経頭蓋交流電流刺激を用いた予備的試験を開始した。睡眠時徐波活動に対する同位相刺激に比べて逆位相刺激の方が、睡眠後の記憶成績がより低下することを確認した。この結果は、本研究の仮説である、刺激効果の周波数位相依存性を示唆するものである。また、サルを用いた経頭蓋集束超音波刺激のシステムの整備を開始した。ラットを用いた予備的試験も開始した。

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  • 記憶形成を促進する睡眠中の脳回路メカニズムの因果的解明

    Grant number：20H00521

    2020.4 - 2024.3

    System name：科学研究費助成事業

    Research category：基盤研究(A)

    Awarding organization：日本学術振興会

    竹田 真己, 中原 潔, 長谷川 功, 地村 弘二, 渡邊 言也

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    Grant amount：\45370000 （ Direct Cost: \34900000 、 Indirect Cost：\10470000 ）

    記憶の固定とよばれる、睡眠中に起きている際に経験した事柄を長期記憶として貯蔵するための情報処理が行われていると考えられているが、いまだ全容解明されていない。我々は、記憶想起中に出現する周波数依存的な協調的脳活動が睡眠中にも再現（リプレイ）されることで記憶固定が促進されるとの仮説を立てた。本研究計画では、ヒトとサルにおいて、高い時空間スケールの脳活動計測と脳活動の位相に合わせたclosed-loop電流刺激法を組み合わせることで、この仮説を検証する。ヒト研究ではfMRIとEEGの同時計測による高い時空間分解能脳活動計測を実現し、サル研究では高密度ECoGによる脳活動計測を行う。記憶想起に関連する脳活動パターンの特徴を深層学習ニューラルネットワークにより同定する。睡眠中の脳活動から記憶想起脳活動パターンを検出し、closed-loop交流電流刺激を行うことで、睡眠後の記憶想起パフォーマンスが増大するか検証する。本研究により、睡眠時リプレイ活動の人為的ブーストを実現し、種横断的な睡眠時リプレイ活動の記憶固定に果たす役割を解明する。コロナウィルス感染症拡大に伴い、一時的に研究に大きな遅延が発生したが、その後研究はおおむね順調に推移し、以下の成果を得た。fMRIとEEGの同時計測系を立ち上げ、得られたmultimodal脳活動データを深層学習によりデコードすることに成功した。この成果は現在論文投稿中である。また、closed-loopシステムを開発し、電流刺激の予備的試験を開始した。その結果、刺激周波数の位相依存的に記憶パフォーマンスが変化することを明らかにした。さらに、サルを用いた共同研究がスタートし、まずはラットを用いた予備的試験を始めることとなった。

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  • Brain organization for theory-of-mind and letter recognition-like behaviors in macaques&#8212;comparing homology with humans

    Grant number：19H01038

    2019.4 - 2023.3

    System name：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

    Research category：Grant-in-Aid for Scientific Research (A)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\45370000 （ Direct Cost: \34900000 、 Indirect Cost：\10470000 ）

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  • Investigation of functional roles of ongoing brain activity in cognition and consciousness

    Grant number：17H00891

    2017.4 - 2021.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (A)

    Awarding organization：Japan Society for the Promotion of Science

    Nakahara Kiyoshi

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    Grant amount：\43420000 （ Direct Cost: \33400000 、 Indirect Cost：\10020000 ）

    In the first half of this research project, we conducted an fMRI study to determine the relationship between encoding performance of episodic memory and temporal changes in networks throughout the brain. Graph analysis revealed that network integration in specific brain regions is enhanced when encoding performance is high. The results were published in the journal eLife.
    In the second half of the project, we conducted an fMRI study on system-level consolidation of remote memory and are currently preparing to publish a paper.
    In addition, we conducted collaborative fMRI studies on frontal lobe function and a ECoG study on macaque monkeys, and published several papers.

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  • 笑い発作に伴うてんかん性脳症の動物モデル―光遺伝学を用いた異常波伝搬経路の検証

    2016.4 - 2018.3

    System name：科学研究費（挑戦的萌芽研究）

    Awarding organization：文部科学省

    長谷川功

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    Authorship：Principal investigator  Grant type：Competitive

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  • Does high presence induced by high definition movies affect eye movements, the autonomic system, and sensation of depth?

    Grant number：15K01279

    2015.4 - 2019.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    IIJIMA Atsuhiko

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    Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

    Biological responses to high definition movies were investigated in focusing on vergence eye movements and the autonomic nervous system. The questions of this study were (1) could high definition movies induce visually induced motion sickness (VIMS) and, (2) could those images elicit depth perceptions in subjects from 2D image objects. Subjects viewed test movies with 3 types of controlled visual resolution and recorded vergence eye movements and ECG and EGG simultaneously. Contrary to our expectations, the results of the experiments showed the high definition movie might have low risk to induce VIMS. Sensation of depth might arise from high resolution images without binocular parallax. These results indicate that high definition images could evoke natural sensation and presence to viewers. Therefore, high definition moves could be effectively for generating exciting emotion without excessive image contents.

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  • Elucidating the autism pathogenesis through brain networks of "theory of mind" and modeling autism in non-human primates

    Grant number：26293261

    2014.4 - 2019.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

    Someya Toshiyuki

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    Grant amount：\17680000 （ Direct Cost: \13600000 、 Indirect Cost：\4080000 ）

    Human neuroimaging studies using various false-belief (FB) attribution tasks have revealed relationships between theory of mind (ToM) and brain networks, including the medial prefrontal cortex (mPFC). In the present study, we examined whether there was causation between neuronal activity in the macaque mPFC and the spontaneous gaze bias to FB targets. We injected hM4Di, an inhibitory DREADD , into the mPFC. We chemogenetically inactivated the mPFC using clozapine N-oxide, a specific ligand to hM4Di. We found that chemogenetic deactivation of the mPFC with CNO injection in monkeys expressing hM4Di specifically altered the gaze bias to the FB target. Thus, our results indicate that neural activity in the macaque mPFC plays a causal role in ToM. These findings suggest the novel possibility that macaques implicitly attribute mental states to others via the operation of neural circuits that are shared with humans, in which the mPFC plays a pivotal role.

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  • 視覚からコミュニケーションへ：皮質脳波法で読み解く大脳神経回路の情報流

    2014.4 - 2017.3

    System name：科学研究費（基盤研究(A)）

    Awarding organization：文部科学省

    長谷川功

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    Authorship：Principal investigator  Grant type：Competitive

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  • How do autistic people recognize wholeness? From cognitive experiment to a nursing model.

    Grant number：25730167

    2013.4 - 2015.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Young Scientists (B)

    Awarding organization：Japan Society for the Promotion of Science

    NISHIYAMA Yuta, HASEGAWA Isao, KAWASAKI Keisuke, NAGASAWA Masaki, KATO Kimiko

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    Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）

    Our research focused on a human ability to comprehend wholeness of some event. To examine how people develop a semantic formation and modulation, we conducted two experiments. Typical development people (6, 7, 9, 11 year-old children and adults) participated in this study. It was demonstrated that a cognitive mode changed with age. Younger people tend to grasp wholeness of events with collecting individual events. On the other hand, older people tend to grasp them with interpreting a few individual events inductively. They suggest that atypical development people might thoroughly adopt the former cognitive mode. To verify it in detail, future works would require some non-linguistic experiments.

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  • 敵か味方か？心の理論とシミュレーションの生物学的根拠を求めて

    2012 - 2013

    System name：科学研究費新学術領域

    Awarding organization：文部科学省

    長谷川功

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    Authorship：Principal investigator  Grant type：Competitive

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  • 柔軟な記号認知と操作のトップダウン大脳制御－サルECoGから拓く比較認知脳科 学

    2011.4 - 2014.3

    System name：科学研究費補助金（基盤研究(B)）

    Awarding organization：文部科学省

    長谷川功

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    Authorship：Principal investigator  Grant type：Competitive

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  • 大脳イメージ伝達支援インターフェイスのリアルタイム動作検証

    2009 - 2010

    System name：A-STEP シーズ顕在化タイプ

    Awarding organization：科学技術振興機構

    長谷川功

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    Authorship：Principal investigator  Grant type：Competitive

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  • 大脳視覚連合野の皮質脳波から文字/図形を直接指示する低侵襲BMI

    2008 - 2012

    System name：脳科学研究戦略推進プログラム課題B・課題A

    Awarding organization：文部科学省

    長谷川功

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    Authorship：Principal investigator  Grant type：Competitive

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  • Neural activity related to construction of compound images in the macaque prefrontal cortex

    Grant number：20500355

    2008 - 2010

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    HASEGAWA Isao, TODA Haruo, IIJIMA Atsuhiko, KAWASAKI Keisuke

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    Grant type：Competitive

    Japanese monkeys were trained in a symbolic construction matching-to-sample (SCMS) task in which 6 compound figures symbolically represent 6 objects. Behavioral experiments showed that the monkeys could learn the SCMS task, and generalize from item-object associations to category-object associations. We developed ultra-thin flexible electrode arrays for electrocorticogram (ECoG), and implanted them into the prefrontal cortex of the monkeys. During the SCMS task, ECoG responses to the second sample element was induced earlier and became larger than during sample presentation of a compound figure in a symbolic matching-to-sample task.

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  • 脳活動から文字を直接指示する言語支援システムの基盤開発

    2008 - 2010

    System name：特定研究助成[ I ]

    Awarding organization：武田科学財団

    長谷川功

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    Authorship：Principal investigator  Grant type：Competitive

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  • 大脳イメージ伝達インターフェイス研究開発の方向性：選択と集中

    2008

    System name：エコイノベーション推進事業

    Awarding organization：新エネルギー・産業技術総合開発機構

    長谷川功

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    Authorship：Principal investigator  Grant type：Competitive

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  • 図形イメージ組み立ての大脳メカニズム：マカクザル動物モデルを用いた生理学的研究

    2007

    System name：東レ科学技術研究助成

    Awarding organization：東レ科学振興会

    長谷川功

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    Authorship：Principal investigator  Grant type：Competitive

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  • 局所フィールド電位の全脳記録

    2007

    System name：研究助成

    Awarding organization：ブレインサイエンス振興財団

    長谷川功

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    Authorship：Principal investigator  Grant type：Competitive

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  • Neural mechanisms of top-down control in primate prefrontal cortex : from single neuron to functional brain imaging

    Grant number：11680803

    1999 - 2001

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    HASEGAWA Isao, TOMITA Hyoe

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    Grant type：Competitive

    It is important to understand the brain mechanisms underlying memory and cognition from cellular events to individual behaviors. Toward this objective, the present project aims to investigate the mechanisms of top-down memory control (Hasegawa et al Science 281, 814-818, 1998) combining (1)single cell recordings of neuronal activity and (2) functional magnetic resonance imaging (fMRl), using animal models with macaque monkeys.
    (1) We conducted single unit recording from inferior temporal cortex in partial split-brain monkeys. We have shown that activity of inferior temporal neurons during memory recall can be induced by top-down signals from prefrontal cortex in the absence of bottom-up signals (Nature 401, 699-703. 1999). We also have recorded activity of prefrontal neurons during oculomotor tasks, and found that prefrontal neurons can code spatial memory information to guide behavior, even when non-spatial cues instruct switch of the target location (Soc. Neurosci. Abstr. 26, 404. 2, 2000).
    (2) We have built fMRl systems for scanning macaque monkeys using 1.5T and 4.7T magnets. With 1.5T magnet, we have shown the feasibility of fMRl to reveal somatotopy in primary and second somatosensory cortex (Eur. J. Neurosci. 11, 4451-56, 1999). With 4.7T magnet we have been making high-contrast activation maps of cortical oculomor areas (Soc. Neurosci. Abstr. 27, 345. 12, 2001). In future, we plan to make functional activation maps with cognitive memory tasks, with the aid of which we will perform functional inactivation and single unit experiments

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Teaching Experience

  • 医学序説 II

    2022
    Institution name：新潟大学

  • 人体の構造と機能II(生理学)

    2021
    Institution name：新潟大学

  • 医学序説 I

    2021
    Institution name：新潟大学

  • 生理学Ⅱ

    2020
    Institution name：新潟大学

  • 医学序説 II

    2020
    Institution name：新潟大学

  • 人体の構造と機能I(生理学I)

    2013
    -
    2014
    Institution name：新潟大学

  • 医学概論II

    2011
    -
    2012
    Institution name：新潟大学

  • 人体の構造と機能I(生理学)

    2010
    Institution name：新潟大学

  • 生理学実習

    2010
    Institution name：新潟大学

  • 脳と心の医科学

    2009
    Institution name：新潟大学

  • 人体の構造と機能II(神経の機能)

    2008
    -
    2014
    Institution name：新潟大学

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