Updated on 2025/09/16
理学 ( 2002.3 大阪大学 )
Doctor(Science) ( 2002.3 Osaka University )
神経生理学 ( 1997.3 大阪大学 )
生物工学 ( 1995.3 大阪大学 )
視覚認識
心の理論
包括脳ネットワーク
記憶
学習
shitsukan recognition
Life Science / Physiology
Niigata University Associate Professor
2015.4
新潟大学 医歯学系 助教
2010
Niigata University Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Sensory and Integrative Medicine Associate Professor
2015.4
Niigata University Faculty of Medicine School of Medicine Assistant Professor
2009.4 - 2015.3
Niigata University Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Sensory and Integrative Medicine Assistant Professor
2009.4 - 2015.3
Optogenetically‐induced sustained hypothalamic hyperexcitability impairs memory via thalamic spread
Masaki Sonoda, Hisao Aimi, Keisuke Kawasaki, Haruo Toda, Shinobu Hirai, Masao Horie, Reiko Meguro, Eishi Asano, Haruo Okado, Shigeki Kameyama, Tetsuya Yamamoto, Isao Hasegawa
Epilepsia 2025.3
Mapping information flow between the inferotemporal and prefrontal cortices via neural oscillations in memory retrieval and maintenance. International journal
Tao Zhou, Keisuke Kawasaki, Takafumi Suzuki, Isao Hasegawa, Anna Wang Roe, Hisashi Tanigawa
Cell reports 42 ( 10 ) 113169 - 113169 2023.10
Chemogenetic attenuation of cortical seizures in nonhuman primates. International journal
Naohisa Miyakawa, Yuji Nagai, Yukiko Hori, Koki Mimura, Asumi Orihara, Kei Oyama, Takeshi Matsuo, Ken-Ichi Inoue, Takafumi Suzuki, Toshiyuki Hirabayashi, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Keisuke Kawasaki, Takafumi Minamimoto
Nature communications 14 ( 1 ) 971 - 971 2023.2
動物種間の皮質脳波応答比較に基づく顔処理の流暢性効果の検討
宍倉 基文, 大貫 良幸, 石下 洋平, 川合 謙介, 叶賀 卓, 三木 治憲, 川嵜 圭祐, 宮川 尚久, 林 隆介
Vision 35 ( 1 ) 23 - 24 2023.1
Decoding distributed oscillatory signals driven by memory and perception in the prefrontal cortex
Hisashi Tanigawa, Kei Majima, Ren Takei, Keisuke Kawasaki, Hirohito Sawahata, Kiyoshi Nakahara, Atsuhiko Iijima, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa
Cell Reports 39 ( 2 ) 110676 - 110676 2022.4
Theory of mind tested by implicit false belief: a simple and full‐fledged mental state attribution
Isao Hasegawa, Jun Egawa, Keisuke Kawasaki, Taketsugu Hayashi, Ryota Akikawa, Toshiyuki Someya, Isao Hasegawa
The FEBS Journal 2022.1
Prediction-Related Frontal-Temporal Network for Omission Mismatch Activity in the Macaque Monkey. International journal
Yuki Suda, Mariko Tada, Takeshi Matsuo, Keisuke Kawasaki, Takeshi Saigusa, Maho Ishida, Tetsuo Mitsui, Hironori Kumano, Kenji Kirihara, Takafumi Suzuki, Kenji Matsumoto, Isao Hasegawa, Kiyoto Kasai, Takanori Uka
Frontiers in psychiatry 13 557954 - 557954 2022
皮質脳波（ECoG）法とfMRIによるサル・ヒトの前頭葉・側頭葉の神経生理学的検証
飯島 淳彦, 劉 南希, 加世堂 竜太郎, 渡辺 卓爾, 中野 広輝, 松尾 健, 川嵜 圭祐, 足立 雄哉, 田中 慎吾, 中原 潔, 長谷川 功
生体医工学 Annual60 ( Abstract ) 111_1 - 111_1 2022
Macaques Exhibit Implicit Gaze Bias Anticipating Others' False-Belief-Driven Actions via Medial Prefrontal Cortex. Reviewed International journal
Taketsugu Hayashi, Ryota Akikawa, Keisuke Kawasaki, Jun Egawa, Takafumi Minamimoto, Kazuto Kobayashi, Shigeki Kato, Yukiko Hori, Yuji Nagai, Atsuhiko Iijima, Toshiyuki Someya, Isao Hasegawa
Cell reports 30 ( 13 ) 4433 - 4444 2020.3
Deep Learning for Channel-Agnostic Brain Decoding across Multiple Subjects
Hiroto Date, Keisuke Kawasaki, Isao Hasegawa, Takayuki Okatani
8th International Winter Conference on Brain-Computer Interface, BCI 2020 2020.2
マカクザルにおける他者の誤信念理解に内側前頭前野が因果的役割を果たす
秋川 諒太, 林 剛丞, 川嵜 圭祐, 江川 純, 南本 敬史, 小林 和人, 加藤 成樹, 堀 由紀子, 永井 裕司, 飯島 淳彦, 染矢 俊幸, 長谷川 功
日本生理学雑誌 82 ( 1 ) 10 - 10 2020.2
硬膜上高密度多点電極を用いたサル一次視覚野における網膜視野の再構成
土屋 貴大, 飯島 淳彦, 川嵜 圭祐, 鈴木 隆文, 長谷川 功, 中原 潔
日本生理学雑誌 82 ( 1 ) 11 - 12 2020.2
三木 治憲, 安斎 健太, 澤山 正貴, 松尾 健, 鈴木 隆文, 岡谷 貴之, 飯島 淳彦, 長谷川 功, 川嵜 圭祐
日本生理学雑誌 82 ( 1 ) 11 - 11 2020.2
マカクザルにおける心の理論の検討および内側前頭前野の不活性化によるその関連性について
林 剛丞, 江川 純, 川崎 圭祐, 秋川 諒太, 長谷川 功, 飯島 淳彦, 染矢 俊幸
精神神経学雑誌 ( 2019特別号 ) S603 - S603 2019.6
Deep Learning for Natural Image Reconstruction from Electrocorticography Signals.
Hiroto Date, Keisuke Kawasaki, Isao Hasegawa, Takayuki Okatani
2331 - 2336 2019
Locally induced neuronal synchrony precisely propagates to specific cortical areas without rhythm distortion Reviewed
Haruo Toda, Keisuke Kawasaki, Sho Sato, Masao Horie, Kiyoshi Nakahara, Asim K. Bepari, Hirohito Sawahata, Takafumi Suzuki, Haruo Okado, Hirohide Takebayashi, Isao Hasegawa
Scientific Reports 8 ( 1 ) 7678 2018.12
Heterogeneous Redistribution of Facial Subcategory Information Within and Outside the Face-Selective Domain in Primate Inferior Temporal Cortex. Reviewed International journal
Naohisa Miyakawa, Kei Majima, Hirohito Sawahata, Keisuke Kawasaki, Takeshi Matsuo, Naoki Kotake, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa
Cerebral cortex (New York, N.Y. : 1991) 28 ( 4 ) 1416 - 1431 2018.4
Decoding value related signals represented in multiple areas of the prefrontal cortex using ECoG electrodes Reviewed
Sakagami Masamichi, Tanaka Shingo, Kawasaki Keisuke, Hasegawa Isao, Suzuki Takafumi
INTERNATIONAL JOURNAL OF PSYCHOLOGY 51 874 2016.7
Associative-memory representations emerge as shared spatial patterns of theta activity spanning the primate temporal cortex Reviewed
Kiyoshi Nakahara, Ken Adachi, Keisuke Kawasaki, Takeshi Matsuo, Hirohito Sawahata, Kei Majima, Masaki Takeda, Sayaka Sugiyama, Ryota Nakata, Atsuhiko Iijima, Hisashi Tanigawa, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa
NATURE COMMUNICATIONS 7 11827 2016.6
Hierarchal information dynamics in spatiotemporal activity pattern of inferior temporal cortex revealed by electrocorticography
Keisuke Kawasaki
Transactions of Japanese Society for Medical and Biological Engineering 54 ( 28 ) S291 - S291 2016
Alternating Zones Selective to Faces and Written Words in the Human Ventral Occipitotemporal Cortex Reviewed
Takeshi Matsuo, Keisuke Kawasaki, Kensuke Kawai, Kei Majima, Hiroshi Masuda, Hiroatsu Murakami, Naoto Kunii, Yukiyasu Kamitani, Shigeki Kameyama, Nobuhito Saito, Isao Hasegawa
CEREBRAL CORTEX 25 ( 5 ) 1265 - 1277 2015.5
Decoding visual object categories from temporal correlations of ECoG signals Reviewed
Kei Majima, Takeshi Matsuo, Keisuke Kawasaki, Kensuke Kawai, Nokihito Saito, Isao Hasegawa, Yukiyasu Kamitani
NEUROIMAGE 90 74 - 83 2014.4
Super multi-channel recording systems with UWB wireless transmitter for BMI Reviewed
Takafumi Suzuki, Hiroshi Ando, Takeshi Yoshida, Hirohito Sawahata, Keisuke Kawasaki, Isao Hasegawa, Kojiro Matsushita, Masayuki Hirata, Toshiki Yoshimine, Kenichi Takizawa
2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) 2014 5208 - 5211 2014
Simultaneous Recording of Single-Neuron Activities and Broad-Area Intracranial Electroencephalography: Electrode Design and Implantation Procedure Reviewed
Takeshi Matsuo, Kensuke Kawai, Takeshi Uno, Naoto Kunii, Naohisa Miyakawa, Kenichi Usami, Keisuke Kawasaki, Isao Hasegawa, Nobuhito Saito
NEUROSURGERY 73 ( 2 Suppl Operative ) 146 - 154 2013.12
Super Multi-Channel Recording System for BMI
Suzuki Takafumi, Ando Hiroshi, Yoshida Takeshi, Sawahata Hirohito, Kawasaki Keisuke, Hasegawa Isao, Matsushita Kojiro, Hirata Masayuki, Yoshimine Toshiki, Takizawa Kenichi
BME 51 M - 2-M-2 2013
LOCAL AND RETROGRADE GENE TRANSFER INTO PRIMATE NEURONAL PATHWAYS VIA ADENO-ASSOCIATED VIRUS SEROTYPE 8 AND 9 Reviewed
Y. Masamizu, T. Okada, K. Kawasaki, H. Ishibashi, S. Yuasa, S. Takeda, I. Hasegawa, K. Nakahara
NEUROSCIENCE 193 249 - 258 2011.10
Intrasulcal electrocorticography in macaque monkeys with minimally invasive neurosurgical protocols Reviewed
Takeshi Matsuo, Keisuke Kawasaki, Takahiro Osada, Hirohito Sawahata, Takafumi Suzuki, Masahiro Shibata, Naohisa Miyakawa, Kiyoshi Nakahara, Atsuhiko Iijima, Noboru Sato, Kensuke Kawai, Nobuhito Saito, Isao Hasegawa
Frontiers in Systems Neuroscience 5 ( 2011 ) 34 2011.5
Intrasulcal ECoG approach to cortico-cortical connectivity using electrical stimulation-induced evoked potentials in macaques Reviewed
Osada Takahiro, Molcard Antoine J, Matsuo Takeshi, Kawasaki Keisuke, Adachi Yusuke, Miyamoto Kentaro, Watanabe Tomomi, Hasegawa Isao, Miyashita Yasushi
NEUROSCIENCE RESEARCH 71 E97 2011
Intrasulcal electrocorticography in macaque monkeys Reviewed
Kawasaki Keisuke, Matsuo Takeshi, Osada Takahiro, Sawahata Hirohito, Suzuki Takafumi, Shibata Masahiro, Miyakawa Naohisa, Nakahara Kiyoshi, Sato Noboru, Kawai Kensuke, Saito Nobuhito, Hasegawa Isao
NEUROSCIENCE RESEARCH 71 E413 - E414 2011
Effects of Familiarity on Neural Activity in Monkey Inferior Temporal Lobe Reviewed
Britt Anderson, Ryan E. B. Mruczek, Keisuke Kawasaki, David Sheinberg
CEREBRAL CORTEX 18 ( 11 ) 2540 - 2552 2008.11
Learning to recognize visual objects with microstimulation in inferior temporal cortex Reviewed
Keisuke Kawasaki, David L. Sheinberg
JOURNAL OF NEUROPHYSIOLOGY 100 ( 1 ) 197 - 211 2008.7
Effects of long-term object familiarity on event-related potentials in the monkey Reviewed
Jessie J. Peissig, Jedediah Singer, Keisuke Kawasaki, David L. Sheinberg
CEREBRAL CORTEX 17 ( 6 ) 1323 - 1334 2007.6
Initial saccades predict manual recognition choices in the monkey Reviewed
David L. Sheinberg, Jessie J. Peissig, Keisuke Kawasaki, Ryan E. B. Mruczek
VISION RESEARCH 46 ( 22 ) 3812 - 3822 2006.10
Presumed inhibitory neurons in the macaque inferior temporal cortex: Visual response properties and functional interactions with adjacent neurons Reviewed
H Tamura, H Kaneko, K Kawasaki, Fujita, I
JOURNAL OF NEUROPHYSIOLOGY 91 ( 6 ) 2782 - 2796 2004.6
Inhibitory mechanisms underlying stimulus-selective responses of inferior temporal neurons Reviewed
H Tamura, H Kaneko, K Kawasaki, Fujita, I
NEURAL BASIS OF EARLY VISION 11 245 - 249 2003
林 剛丞, 江川 純, 川嵜 圭祐, 秋川 諒太, 長谷川 功, 飯島 敦彦, 染矢 俊幸
新潟医学会雑誌 135 ( 7 ) 139 - 139 2021.7
Chemogenetic activation of the amygdala specifically disrupts the representation of socio-emotional information in the macaque ventral visual cortex
Miyakawa N, Nagai Y, Hori Y, Matsuo T, Suzuki T, Inoue K, Takada M, Suhara T, Kawasaki K, Minamimoto T
2019.7
マカクザルにおける心の理論の検討および内側前頭前野の不活性化によるその関連性について
林 剛丞, 江川 純, 川崎 圭祐, 秋川 諒太, 長谷川 功, 飯島 淳彦, 染矢 俊幸
精神神経学雑誌 ( 2019特別号 ) S603 - S603 2019.6
TANIGAWA Hisashi, TAKEI Ren, MAJIMA Kei, KAWASAKI Keisuke, SAWAHATA Hiroto, NAKAHARA Kiyoshi, SUZUKI Takafumi, KAMIYA Yukiyasu, HASEGAWA Isao
日本神経回路学会全国大会講演論文集 25th 103 2015.9
Development of ECoG based multi-channel recording BMI system using UWB wireless communications
ANDO Hiroshi, TAKIZAWA Kenichi, YOSHIDA Takeshi, SAWAHATA Hirohito, KAWASAKI Keisuke, HASEGAWA Isao, MATSUSHITA Kojiro, HIRATA Masayuki, YOSHIMINE Toshiki, SUZUKI Takafumi
日本生体医工学会大会プログラム・論文集(CD-ROM) 53rd ROMBUNNO.SY3-03-6 - 78-SY-79 2014
松尾健, 川合謙介, 宇野健志, 國井尚人, 川嵜圭祐, 宮川尚久, 長谷川功, 斉藤延人
日本てんかん外科学会プログラム・抄録集 36th 50 2012.12
サル下側頭葉皮質の動きの処理について
中島 啓, 川嵜 圭祐, 澤畑 博人, 鈴木 隆文, 長谷川 功
Vision 24 ( 3 ) 119 - 119 2012.7
皮質脳波の時間的パターンを用いた視覚物体カテゴリーのデコーディング(Neural decoding of visual object categories using temporal patterns of ECoG signals)
間島 慶, 松尾 健, 川嵜 圭祐, 川合 謙介, 増田 浩, 國井 尚人, 村上 博淳, 鎌田 恭輔, 亀山 茂樹, 斉藤 延人, 長谷川 功, 神谷 之康
神経化学 49 ( 2-3 ) 724 - 724 2010.8
皮質脳波を用いた側頭葉視覚領野の機能マッピング(Electrocorticographic mapping of human ventral visual areas)
松尾 健, 川嵜 圭祐, 川合 謙介, 増田 浩, 國井 尚人, 村上 博淳, 間島 慶, 鎌田 恭輔, 神谷 之康, 亀山 茂樹, 齋藤 延人, 長谷川 功
神経化学 49 ( 2-3 ) 508 - 508 2010.8
Accuracy of Pupil Detection with and without Head Restraints
KIRYU Yuichiro, IIJIMA Atsuhiko, KAWASAKI Keisuke, MIYAKAWA Naohisa, MAEDA Yoshinobu, HASEGAWA Isao
IEICE technical report 109 ( 194 ) 19 - 22 2009.9
Visual response properties of presumed inhibitory neurons in the macaque inferior temporal cortex
TAMURA Hiroshi, KANEKO Hidekazu, KAWASAKI Keisuke, FUJITA Ichiro
51 96 - 96 2002.8
Neural basis of adaptive decision making and simulation of others in the brain depending on the social contexts
Grant number：24K09682
2024.4 - 2027.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Scientific Research (C)
Awarding organization：Japan Society for the Promotion of Science
Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）
Neural Correlates of Theory of Mind Development
Grant number：23KK0145
2023.9 - 2027.3
System name：Grants-in-Aid for Scientific Research
Research category：Fund for the Promotion of Joint International Research (International Collaborative Research)
Awarding organization：Japan Society for the Promotion of Science
Grant amount：\21060000 （ Direct Cost: \16200000 、 Indirect Cost：\4860000 ）
Brain network dynamics for theory of mind
Grant number：22K07318
2022.4 - 2025.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Scientific Research (C)
Awarding organization：Japan Society for the Promotion of Science
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
Neural mechanisms of preferential looking for shitsukan
Grant number：21H05813
2021.9 - 2023.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Transformative Research Areas (A)
Awarding organization：Japan Society for the Promotion of Science
Grant amount：\7540000 （ Direct Cost: \5800000 、 Indirect Cost：\1740000 ）
Investigation and manipulation of neural networks for adaptive decision making in competitive and cooperative interactions
Grant number：21K07258
2021.4 - 2024.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Scientific Research (C)
Awarding organization：Japan Society for the Promotion of Science
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
The neural basis of "outwitting others": behavioral selection based on simulating others in the brain
Grant number：18K07349
2018.4 - 2021.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Scientific Research (C)
Awarding organization：Japan Society for the Promotion of Science
Tanaka Shingo
Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）
Although multiple brain areas are involved in “the theory of mind”, the ability to infer the mind of others, the neural process of inferring others which changes with interaction with the self, and the neural basis of action selection according to the inferred others in the brain and the surrounding situation is still unknown. In this study, we developed an interactive experimental task and aimed to elucidate the neurophysiological basis of strategic behavioral selection using simulated others in the brain. First, we performed fMRI experiments to record the brain activity of human subjects. We used a computational behavioral model to explain the behavior of human subjects and explored the brain activity that correlated with the parameters of the model, and found activation in the TPJ and prefrontal cortex. In addition, we developed ECoG electrodes to record neural activity from macaque macaques and trained them to perform the interactive task.
Reactivation of memory representation by pattern stimulation of the brain
Grant number：17H06268
2017.6 - 2020.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Challenging Research (Pioneering)
Awarding organization：Japan Society for the Promotion of Science
Nakahara Kiyoshi
Grant amount：\26000000 （ Direct Cost: \20000000 、 Indirect Cost：\6000000 ）
We attempted to reconstruct visual images from visual responses of electrocorticogram (ECoG) in the monkey primary visual cortex (V1). We also examined ECoG responses to the illusory surface perceived by color filling-in using one kind of the illusory images, "the neon color spreading". We are currently conducting the reconstruction of the visual image using a deep neural network. As a result of analyzing the ECoG responses to the illusory surface, we found visual responses to the perception of the illusory surface between 150 ms and 200 ms after the stimulus onset. The spatial extent of the visual response to the illusory surface in V1 was approximately the same as the visual angle of the perceived illusion in the horizontal direction, while it was more expanded in the vertical direction.
Neural mechanism of hierarchical categorization
Grant number：16K01959
2016.4 - 2019.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Scientific Research (C)
Awarding organization：Japan Society for the Promotion of Science
Kawasaki Keisuke, Suzuki Takafumi, Matsumoto Narihisa
Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）
Abstraction is a key computing underling our intelligent capacity such as thinking, inference and linguistic activity. However neuronal basis of the cognitive process is largely unknown mainly because a lack of an appropriate animal model which enable us to measure and manipulate the direct neural activity. In this project, thus we developed a hierarchal categorization task for monkeys. We show that two out of the two monkeys learned the hierarchal categorization in which the monkey has to explicitly classify the natural categories with three abstraction levels. We also investigated the neural representation of face and its subcategories. Neural activities were recorded by electrocorticogram, local field potential and multi-unit activity in inferior temporal cortex (ITC). The results suggest that the finer category clusters are heterogeneously distributed even outside their parent category cluster and dynamically increase heterogeneity along with the cortical processing in the ITC.
Deep Representation Learning of Shitsukan Using Vision and Language
Grant number：15H05919
2015.6 - 2020.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Awarding organization：Japan Society for the Promotion of Science
Okatani Takayuki
Grant amount：\59410000 （ Direct Cost: \45700000 、 Indirect Cost：\13710000 ）
We have obtained step-by-step achievements towards realizing an AI that can recognize the Shitsukan of an object from its single image. We have developed the following methods: i) a CNN-based method for Shitsukan recognition based on learning to rank image pairs; ii) a method for mining visually recognizable Shitsukan concepts from pairs of images and their descriptions on the Web; iii) a method for generating appropriate titles for images of products while capturing the context-aware Shitsukan concepts. The developments of the above lead to the conclusion that Shitsukan recognition is "comprehensive image recognition," and we successfully developed a network with an attention mechanism, which is an offshoot of today's multimodal deep neural networks for image understanding.
Elucidating the autism pathogenesis through brain networks of "theory of mind" and modeling autism in non-human primates
Grant number：26293261
2014.4 - 2019.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Scientific Research (B)
Awarding organization：Japan Society for the Promotion of Science
Someya Toshiyuki
Grant amount：\17680000 （ Direct Cost: \13600000 、 Indirect Cost：\4080000 ）
Human neuroimaging studies using various false-belief (FB) attribution tasks have revealed relationships between theory of mind (ToM) and brain networks, including the medial prefrontal cortex (mPFC). In the present study, we examined whether there was causation between neuronal activity in the macaque mPFC and the spontaneous gaze bias to FB targets. We injected hM4Di, an inhibitory DREADD , into the mPFC. We chemogenetically inactivated the mPFC using clozapine N-oxide, a specific ligand to hM4Di. We found that chemogenetic deactivation of the mPFC with CNO injection in monkeys expressing hM4Di specifically altered the gaze bias to the FB target. Thus, our results indicate that neural activity in the macaque mPFC plays a causal role in ToM. These findings suggest the novel possibility that macaques implicitly attribute mental states to others via the operation of neural circuits that are shared with humans, in which the mPFC plays a pivotal role.
Neural mechanisms of visual communications revealed with electrocorticography.
Grant number：26242088
2014.4 - 2017.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Scientific Research (A)
Awarding organization：Japan Society for the Promotion of Science
Hasegawa Isao, SUZUKI Takafumi, TODA Haruo, KAWASAKI Keisuke, IIJIMA Atsuhiko, NISHIYAMA Yuta
Grant amount：\44850000 （ Direct Cost: \34500000 、 Indirect Cost：\10350000 ）
We developed a method to quantify the information flow of the cerebral cortex as the local transfer entropy from the spatial pattern of the electrocorticographic signals with various dimensions. With this approach, we identified repetitions of forward and backward waves in the macaque inferior temporal cortex following visual stimulation with dynamic topological changes. Next we found that spatial patterns of theta-band powers spanning a wide area in the medial temporal lobe can represent associative memory, which is reorganized through associative learning. In the prefrontal cortex, we identified flows of theta-band powers associated with symbolic conversion and construction. Finally, microstructure of surround suppression was revealed with spatiotemporal two-dimensional fast Fourier transformation of visually evoked signals in the rat visual cortex.
Research on memory retrieval mechanisms in the primate medial temporal lobe using high-density electrocorticography
Grant number：25282249
2013.4 - 2017.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Scientific Research (B)
Awarding organization：Japan Society for the Promotion of Science
Kiyoshi Nakahara, SAWAHATA Hirohito, ADACHI Ken
Grant amount：\19760000 （ Direct Cost: \15200000 、 Indirect Cost：\4560000 ）
Using high-density electrocorticography (ECoG), we investigated local-field potentials spanning the monkey temporal lobes, and found that the visual pair-association memory is encoded in spatial patterns of theta activity in the primate medial temporal lobe.
Spatiotemporal patterns in inferior temporal cortex during visual object recognition probing by wide area brain stimulation
Grant number：25350997
2013.4 - 2016.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Scientific Research (C)
Awarding organization：Japan Society for the Promotion of Science
Kawasaki Keisuke
Grant amount：\5070000 （ Direct Cost: \3900000 、 Indirect Cost：\1170000 ）
The inferior temporal cortex (IT) of the monkey plays an essential role in visual object recognition. Neurons in IT encodes visual features for object identification such as shape, color and surface properties. It is still unclear how wide areal activity patterns of the IT contribute the recognition process. In this study we aimed 1) to identify the wide areal activity patterns underlying visual recognition 2) to identify the effect of the perturbation on spatiotemporal activity patterns of IT. We revealed that recognition memory representation emerged as shared spatial patterns of theta activity spanning the IT. We also reveal that the spatiotemporal activity patterns of the IT engaged information flow. The fast oscillation of feedforward and feedback flow was observed. The flow dynamics may reflects hierarchal neuronal information processing. We developed a multichannel simultaneous recording and stimulation system for wide area brain stimulation.
皮質脳波法による生き物らしい質感の脳内表現の研究
Grant number：25135716
2013.4 - 2015.3
System name：科学研究費助成事業
Research category：新学術領域研究(研究領域提案型)
Awarding organization：日本学術振興会
川嵜 圭祐
Grant amount：\10400000 （ Direct Cost: \8000000 、 Indirect Cost：\2400000 ）
視覚に基づいた抽象的なカテゴリはどのような神経メカニズムによって実現されているのでしょうか？ヒトはさまざまな物体に”生き物らしさ”を感じて（アニマシー知覚）、物体を動物と非動物のカテゴリーに大別できます。これまでの研究から特定の動きのパターンや表面のテクスチャパターンなど、この知覚に重要な視覚的物理パラメータや、関連する脳領域が示唆されています。しかし、複数の物理パラメータが知覚に関与する仕組みや複数の関連脳領域がどのように協調してアニマシー知覚を生み出す機序は不明です。視線解析等の行動学的な研究からサルにおいても同様のアニマシー知覚が存在することが示唆されています。そこで本研究では、概念的な質感の動物モデルとしてサルのアニマシー知覚を行動学的、神経科学的に検証することを目的としました。2頭のニホンザルを用いて、動物・非動物の動画の種類に応じて適切な記号を80％以上の成績で正しく選択できるように訓練を行いました。学習達成後、他の新規の動画例でも、記号と動画のカテゴリの割当が汎化するか検討しました。新規の例を導入した場合には初学習に比べて早く基準成績に達し、学習の節約が見られました。また１頭のサルでは初めてみた動画に対しても正しいカテゴリ分けができるようになることがわかりました。これらの結果は条件性反応だけでは説明できず学習の汎化が見られました。また上側頭溝内を含む下側頭葉皮質(ITC)と、内側部を含む前頭葉皮質（PFC）から皮質脳波記録を行い、動物の動き、非生物物体の動きが描出された２秒間の映像を呈示したときの応答を記録しました。 応答振幅はITC，PFCのそれぞれで特徴的な時間経過を示した。個々の刺激動画に対する選択性はどちらの領野でも、幾つかのピークを形成しながら上昇することがわかりました。カテゴリ応答選択性もやはり幾つかのピークを形成していました。
How do autistic people recognize wholeness? From cognitive experiment to a nursing model.
Grant number：25730167
2013.4 - 2015.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Young Scientists (B)
Awarding organization：Japan Society for the Promotion of Science
NISHIYAMA Yuta, HASEGAWA Isao, KAWASAKI Keisuke, NAGASAWA Masaki, KATO Kimiko
Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）
Our research focused on a human ability to comprehend wholeness of some event. To examine how people develop a semantic formation and modulation, we conducted two experiments. Typical development people (6, 7, 9, 11 year-old children and adults) participated in this study. It was demonstrated that a cognitive mode changed with age. Younger people tend to grasp wholeness of events with collecting individual events. On the other hand, older people tend to grasp them with interpreting a few individual events inductively. They suggest that atypical development people might thoroughly adopt the former cognitive mode. To verify it in detail, future works would require some non-linguistic experiments.
Neural mechanism of flexible cognition and use of symbols: a comparative macaque ECoG and human fMRI study
Grant number：23300150
2011.4 - 2014.3
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Scientific Research (B)
Awarding organization：Japan Society for the Promotion of Science
HASEGAWA ISAO, NAKAHARA Kiyoshi, KITAGAWA Junichi, KAWASAKI Keisuke
Grant amount：\20150000 （ Direct Cost: \15500000 、 Indirect Cost：\4650000 ）
We developed a visual sign system where object categories were symbolically represented by distinct combinations of visual elements. Macaque monkeys (Macaca fuscata) learned to use these composite symbols by combining and decomposing elements. We conducted multichannel electrtocorticographic (ECoG) recording from the prefrontal cortex and inferior temporal cortex of the monkeys. Analyses of event-related spectral perturbation of the prefrontal ECoG signals revealed areal segregation for combination and decomposition of symbol elements in specific frequency band powers. Functional magnetic resonance imaging in healthy human subjects revealed insular activation during reading particularly when segmentation of letterstrings was required compared to segmentation was not required. Furthermore, we tested symmetry of symbolic use in three macaque monkeys. Symbolic association was symmetrically learned in two macaques but not in one animal, indicating the need for further testing.
皮質脳波記録法を用いた視覚学習に伴う脳機能マップの可塑性の検証
Grant number：23135512
2011.4 - 2013.3
System name：科学研究費助成事業
Research category：新学術領域研究(研究領域提案型)
Awarding organization：日本学術振興会
川嵜 圭祐
Grant amount：\8320000 （ Direct Cost: \6400000 、 Indirect Cost：\1920000 ）
霊長類の大脳皮質下側頭葉には特定の種類の物体の形や色を専門的に処理する部位が存在する。これらの機能モジュールが認知学習を習得する際にどのようなどのような機能的な変化を引き起こしているのか？本研究では大脳皮質の広い領域から長期間にわたり高時空間分解能で記録が可能な皮質脳波（Electrocorticogram（ECoG））法をサル下側頭葉皮質に適用して、質感の知覚、情報処理の経験依存的な側面を明らかにすることを目的に以下の実験を行った。
①ECoG法によって上側頭溝を含む下側頭葉皮質の視覚モジュールマップを高い時空間分解能で同定する、②サルが訓練によって、色、形、動きを組み合わせてつくりだされる新規物体カテゴリ学習を習得できるか行動学的に検証する、③学習に伴う機能マップの変化を同定する。
①について、下側頭葉皮質での長期ECoG法を確立して、広範囲における視覚応答の伝搬様式を高時空間分解能で可視化することに成功した。視覚応答は、いくつかの速度、方向の異なる神経活動伝搬が複数回繰り返す様子としてとらえられた。先行研究から視覚モジュールは階層的な視覚情報処理によって形成されていくと示唆されてきたが、今回の結果は視覚モジュール形成過程において、階層的処理に加え、動的な繰り返し現象が重要であることを示唆する。また応答の時間周波数解析によって30-100Hz程度の比較的高い周波数成分に形と動きのモジュールが見出されることがわかった。②についてニホンザルに１頭に記号を使った動物・非動物動画のカテゴリ分け課題を訓練することに成功した。初学習の動画セットを学習後、新規動画セットを訓練するとより早くカテゴリ分けを習得することがわかった。③について、見慣れた動画セットと新規動画セットに対する時間周波数応答に差が見いだされた。
Neural activity related to construction of compound images in the macaque prefrontal cortex
Grant number：20500355
2008 - 2010
System name：Grants-in-Aid for Scientific Research
Research category：Grant-in-Aid for Scientific Research (C)
Awarding organization：Japan Society for the Promotion of Science
HASEGAWA Isao, TODA Haruo, IIJIMA Atsuhiko, KAWASAKI Keisuke
Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）
Japanese monkeys were trained in a symbolic construction matching-to-sample (SCMS) task in which 6 compound figures symbolically represent 6 objects. Behavioral experiments showed that the monkeys could learn the SCMS task, and generalize from item-object associations to category-object associations. We developed ultra-thin flexible electrode arrays for electrocorticogram (ECoG), and implanted them into the prefrontal cortex of the monkeys. During the SCMS task, ECoG responses to the second sample element was induced earlier and became larger than during sample presentation of a compound figure in a symbolic matching-to-sample task.
生理学実習
人体の構造と機能I(生理学)
