Updated on 2025/09/08

写真a

 
KAWASAKI Keisuke
 
Organization
Academic Assembly Institute of Medicine and Dentistry IGAKU KEIRETU Associate Professor
Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Sensory and Integrative Medicine Associate Professor
Title
Associate Professor
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Degree

  • 理学 ( 2002.3   大阪大学 )

  • Doctor(Science) ( 2002.3   Osaka University )

  • 神経生理学 ( 1997.3   大阪大学 )

  • 生物工学 ( 1995.3   大阪大学 )

Research Interests

  • 視覚認識

  • 心の理論

  • 包括脳ネットワーク

  • 記憶

  • 学習

  • shitsukan recognition

Research Areas

  • Life Science / Physiology

Research History (researchmap)

  • Niigata University   Associate Professor

    2015.4

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  • 新潟大学 医歯学系   助教

    2010

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Research History

  • Niigata University   Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Sensory and Integrative Medicine   Associate Professor

    2015.4

  • Niigata University   Faculty of Medicine School of Medicine   Assistant Professor

    2009.4 - 2015.3

  • Niigata University   Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Sensory and Integrative Medicine   Assistant Professor

    2009.4 - 2015.3

 

Papers

  • Optogenetically‐induced sustained hypothalamic hyperexcitability impairs memory via thalamic spread

    Masaki Sonoda, Hisao Aimi, Keisuke Kawasaki, Haruo Toda, Shinobu Hirai, Masao Horie, Reiko Meguro, Eishi Asano, Haruo Okado, Shigeki Kameyama, Tetsuya Yamamoto, Isao Hasegawa

    Epilepsia   2025.3

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    Objective

    Clinical investigators have hypothesized that interictal epileptiform discharges (IEDs) generated by hypothalamic hamartoma (HH) lead to cognitive dysfunction in patients with drug‐resistant gelastic seizures. Herein we provide causal evidence supporting this hypothesis by demonstrating that excitatory neural bursts, when propagating from the HH to the mediodorsal thalamus during the encoding period, impair working memory.

    Methods

    By employing channelrhodopsin‐2 photostimulation, we induced excessive neural excitation in Long‐Evans rats, resembling IEDs, at the axon terminals of the lateral hypothalamus projecting toward the mediodorsal thalamus and prelimbic cortex. We recorded local field potentials (LFPs) at these sites and assessed the performance of working memory tasks with and without photostimulation. Utilizing support vector machine analysis on LFP trials under sham photostimulation, we identified the neural correlates of successful task performance. Through mixed model analyses, we evaluated the impacts of photostimulation timing and the alteration in LFP amplitude induced by photostimulation on task performance.

    Results

    Ten rats completed operant conditioning using a spout lever system after receiving an average of 70.7 days of training, at a rate of 135.2 trials per day. During sham photostimulation, successful trials were associated with a shorter duration of the working memory maintenance period, as well as an augmentation in the 10‐ to 14‐Hz LFP amplitude at the mediodorsal thalamus and prelimbic cortex during the memory encoding phase. Photostimulation at the mediodorsal thalamus during encoding reduced the odds of a trial being successful by 0.19. Conversely, excessive mediodorsal thalamus LFP augmentation induced by photostimulation during encoding increased the odds of a trial being unsuccessful by 1.04.

    Significance

    Excessive neural excitation, specifically propagating from the lateral hypothalamus to the mediodorsal thalamus during encoding, alters physiological neural activity and transiently impairs working memory. This study clarifies the pathophysiological mechanism underlying cognitive disabilities associated with working memory impairment in HH‐related epileptic encephalopathy.

    DOI: 10.1111/epi.18321

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  • Mapping information flow between the inferotemporal and prefrontal cortices via neural oscillations in memory retrieval and maintenance. International journal

    Tao Zhou, Keisuke Kawasaki, Takafumi Suzuki, Isao Hasegawa, Anna Wang Roe, Hisashi Tanigawa

    Cell reports   42 ( 10 )   113169 - 113169   2023.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    Interaction between the inferotemporal (ITC) and prefrontal (PFC) cortices is critical for retrieving information from memory and maintaining it in working memory. Neural oscillations provide a mechanism for communication between brain regions. However, it remains unknown how information flow via neural oscillations is functionally organized in these cortices during these processes. In this study, we apply Granger causality analysis to electrocorticographic signals from both cortices of monkeys performing visual association tasks to map information flow. Our results reveal regions within the ITC where information flow to and from the PFC increases via specific frequency oscillations to form clusters during memory retrieval and maintenance. Theta-band information flow in both directions increases in similar regions in both cortices, suggesting reciprocal information exchange in those regions. These findings suggest that specific subregions function as nodes in the memory information-processing network between the ITC and the PFC.

    DOI: 10.1016/j.celrep.2023.113169

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  • Chemogenetic attenuation of cortical seizures in nonhuman primates. International journal

    Naohisa Miyakawa, Yuji Nagai, Yukiko Hori, Koki Mimura, Asumi Orihara, Kei Oyama, Takeshi Matsuo, Ken-Ichi Inoue, Takafumi Suzuki, Toshiyuki Hirabayashi, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Keisuke Kawasaki, Takafumi Minamimoto

    Nature communications   14 ( 1 )   971 - 971   2023.2

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    Epilepsy is a disorder in which abnormal neuronal hyperexcitation causes several types of seizures. Because pharmacological and surgical treatments occasionally interfere with normal brain function, a more focused and on-demand approach is desirable. Here we examined the efficacy of a chemogenetic tool-designer receptors exclusively activated by designer drugs (DREADDs)-for treating focal seizure in a nonhuman primate model. Acute infusion of the GABAA receptor antagonist bicuculline into the forelimb region of unilateral primary motor cortex caused paroxysmal discharges with twitching and stiffening of the contralateral arm, followed by recurrent cortical discharges with hemi- and whole-body clonic seizures in two male macaque monkeys. Expression of an inhibitory DREADD (hM4Di) throughout the seizure focus, and subsequent on-demand administration of a DREADD-selective agonist, rapidly suppressed the wide-spread seizures. These results demonstrate the efficacy of DREADDs for attenuating cortical seizure in a nonhuman primate model.

    DOI: 10.1038/s41467-023-36642-6

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  • 動物種間の皮質脳波応答比較に基づく顔処理の流暢性効果の検討

    宍倉 基文, 大貫 良幸, 石下 洋平, 川合 謙介, 叶賀 卓, 三木 治憲, 川嵜 圭祐, 宮川 尚久, 林 隆介

    Vision   35 ( 1 )   23 - 24   2023.1

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    Language:Japanese   Publisher:日本視覚学会  

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  • Decoding distributed oscillatory signals driven by memory and perception in the prefrontal cortex

    Hisashi Tanigawa, Kei Majima, Ren Takei, Keisuke Kawasaki, Hirohito Sawahata, Kiyoshi Nakahara, Atsuhiko Iijima, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa

    Cell Reports   39 ( 2 )   110676 - 110676   2022.4

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.celrep.2022.110676

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  • Theory of mind tested by implicit false belief: a simple and full‐fledged mental state attribution

    Isao Hasegawa, Jun Egawa, Keisuke Kawasaki, Taketsugu Hayashi, Ryota Akikawa, Toshiyuki Someya, Isao Hasegawa

    The FEBS Journal   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1111/febs.16322

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  • Prediction-Related Frontal-Temporal Network for Omission Mismatch Activity in the Macaque Monkey. International journal

    Yuki Suda, Mariko Tada, Takeshi Matsuo, Keisuke Kawasaki, Takeshi Saigusa, Maho Ishida, Tetsuo Mitsui, Hironori Kumano, Kenji Kirihara, Takafumi Suzuki, Kenji Matsumoto, Isao Hasegawa, Kiyoto Kasai, Takanori Uka

    Frontiers in psychiatry   13   557954 - 557954   2022

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    Sensory prediction is considered an important element of mismatch negativity (MMN) whose reduction is well known in patients with schizophrenia. Omission MMN is a variant of the MMN which is elicited by the absence of a tone previously sequentially presented. Omission MMN can eliminate the effects of sound differences in typical oddball paradigms and affords the opportunity to identify prediction-related signals in the brain. Auditory predictions are thought to reflect bottom-up and top-down processing within hierarchically organized auditory areas. However, the communications between the various subregions of the auditory cortex and the prefrontal cortex that generate and communicate sensory prediction-related signals remain poorly understood. To explore how the frontal and temporal cortices communicate for the generation and propagation of such signals, we investigated the response in the omission paradigm using electrocorticogram (ECoG) electrodes implanted in the temporal, lateral prefrontal, and orbitofrontal cortices of macaque monkeys. We recorded ECoG data from three monkeys during the omission paradigm and examined the functional connectivity between the temporal and frontal cortices by calculating phase-locking values (PLVs). This revealed that theta- (4-8 Hz), alpha- (8-12 Hz), and low-beta- (12-25 Hz) band synchronization increased at tone onset between the higher auditory cortex and the frontal pole where an early omission response was observed in the event-related potential (ERP). These synchronizations were absent when the tone was omitted. Conversely, low-beta-band (12-25 Hz) oscillation then became stronger for tone omission than for tone presentation approximately 200 ms after tone onset. The results suggest that auditory input is propagated to the frontal pole via the higher auditory cortex and that a reciprocal network may be involved in the generation of auditory prediction and prediction error. As impairments of prediction may underlie MMN reduction in patients with schizophrenia, an aberrant hierarchical temporal-frontal network might be related to this pathological condition.

    DOI: 10.3389/fpsyt.2022.557954

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  • 皮質脳波(ECoG)法とfMRIによるサル・ヒトの前頭葉・側頭葉の神経生理学的検証

    飯島 淳彦, 劉 南希, 加世堂 竜太郎, 渡辺 卓爾, 中野 広輝, 松尾 健, 川嵜 圭祐, 足立 雄哉, 田中 慎吾, 中原 潔, 長谷川 功

    生体医工学   Annual60 ( Abstract )   111_1 - 111_1   2022

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    Language:Japanese   Publisher:公益社団法人 日本生体医工学会  

    本研究では,ヒトおよびマカクザル(ニホンザル)の前頭葉と側頭葉に留置した皮質脳波(ECoG)電極から記録した神経活動と,ヒトを対象としたfMRIの脳機能画像を用いて,高次機能に関連した神経回路の検証を行なっている.特に,言語機能に関わる脳領域の推定と各領域の連関,視覚的な認知に寄与する神経ネットワークについての研究成果を報告する.

    DOI: 10.11239/jsmbe.annual60.111_1

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  • Macaques Exhibit Implicit Gaze Bias Anticipating Others' False-Belief-Driven Actions via Medial Prefrontal Cortex. Reviewed International journal

    Taketsugu Hayashi, Ryota Akikawa, Keisuke Kawasaki, Jun Egawa, Takafumi Minamimoto, Kazuto Kobayashi, Shigeki Kato, Yukiko Hori, Yuji Nagai, Atsuhiko Iijima, Toshiyuki Someya, Isao Hasegawa

    Cell reports   30 ( 13 )   4433 - 4444   2020.3

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    The ability to infer others' mental states is essential to social interactions. This ability, critically evaluated by testing whether one attributes false beliefs (FBs) to others, has been considered to be uniquely hominid and to accompany the activation of a distributed brain network. We challenge the taxon specificity of this ability and identify the causal brain locus by introducing an anticipatory-looking FB paradigm combined with chemogenetic neuronal manipulation in macaque monkeys. We find spontaneous gaze bias of macaques implicitly anticipating others' FB-driven actions. Silencing of the medial prefrontal neuronal activity with inhibitory designer receptor exclusively activated by designer drugs (DREADDs) specifically eliminates the implicit gaze bias while leaving the animals' visually guided and memory-guided tracking abilities intact. Thus, neuronal activity in the medial prefrontal cortex could have a causal role in FB-attribution-like behaviors in the primate lineage, emphasizing the importance of probing the neuronal mechanisms underlying theory of mind with relevant macaque animal models.

    DOI: 10.1016/j.celrep.2020.03.013

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  • Deep Learning for Channel-Agnostic Brain Decoding across Multiple Subjects

    Hiroto Date, Keisuke Kawasaki, Isao Hasegawa, Takayuki Okatani

    8th International Winter Conference on Brain-Computer Interface, BCI 2020   2020.2

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    Language:English   Publishing type:Research paper (international conference proceedings)   Publisher:Institute of Electrical and Electronics Engineers Inc.  

    DOI: 10.1109/BCI48061.2020.9061615

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  • マカクザルにおける他者の誤信念理解に内側前頭前野が因果的役割を果たす

    秋川 諒太, 林 剛丞, 川嵜 圭祐, 江川 純, 南本 敬史, 小林 和人, 加藤 成樹, 堀 由紀子, 永井 裕司, 飯島 淳彦, 染矢 俊幸, 長谷川 功

    日本生理学雑誌   82 ( 1 )   10 - 10   2020.2

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    Language:Japanese   Publisher:(一社)日本生理学会  

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  • 硬膜上高密度多点電極を用いたサル一次視覚野における網膜視野の再構成

    土屋 貴大, 飯島 淳彦, 川嵜 圭祐, 鈴木 隆文, 長谷川 功, 中原 潔

    日本生理学雑誌   82 ( 1 )   11 - 12   2020.2

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  • 物体素材に対するサル下側頭葉皮質における皮質脳波応答

    三木 治憲, 安斎 健太, 澤山 正貴, 松尾 健, 鈴木 隆文, 岡谷 貴之, 飯島 淳彦, 長谷川 功, 川嵜 圭祐

    日本生理学雑誌   82 ( 1 )   11 - 11   2020.2

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  • マカクザルにおける心の理論の検討および内側前頭前野の不活性化によるその関連性について

    林 剛丞, 江川 純, 川崎 圭祐, 秋川 諒太, 長谷川 功, 飯島 淳彦, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S603 - S603   2019.6

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  • Deep Learning for Natural Image Reconstruction from Electrocorticography Signals.

    Hiroto Date, Keisuke Kawasaki, Isao Hasegawa, Takayuki Okatani

    2331 - 2336   2019

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    Publishing type:Research paper (international conference proceedings)  

    DOI: 10.1109/BIBM47256.2019.8983029

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    Other Link: https://dblp.uni-trier.de/db/conf/bibm/bibm2019.html#DateKHO19

  • Locally induced neuronal synchrony precisely propagates to specific cortical areas without rhythm distortion Reviewed

    Haruo Toda, Keisuke Kawasaki, Sho Sato, Masao Horie, Kiyoshi Nakahara, Asim K. Bepari, Hirohito Sawahata, Takafumi Suzuki, Haruo Okado, Hirohide Takebayashi, Isao Hasegawa

    Scientific Reports   8 ( 1 )   7678   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Nature Publishing Group  

    DOI: 10.1038/s41598-018-26054-8

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  • Heterogeneous Redistribution of Facial Subcategory Information Within and Outside the Face-Selective Domain in Primate Inferior Temporal Cortex. Reviewed International journal

    Naohisa Miyakawa, Kei Majima, Hirohito Sawahata, Keisuke Kawasaki, Takeshi Matsuo, Naoki Kotake, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa

    Cerebral cortex (New York, N.Y. : 1991)   28 ( 4 )   1416 - 1431   2018.4

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    The inferior temporal cortex (ITC) contains neurons selective to multiple levels of visual categories. However, the mechanisms by which these neurons collectively construct hierarchical category percepts remain unclear. By comparing decoding accuracy with simultaneously acquired electrocorticogram (ECoG), local field potentials (LFPs), and multi-unit activity in the macaque ITC, we show that low-frequency LFPs/ECoG in the early evoked visual response phase contain sufficient coarse category (e.g., face) information, which is homogeneous and enhanced by spatial summation of up to several millimeters. Late-induced high-frequency LFPs additionally carry spike-coupled finer category (e.g., species, view, and identity of the face) information, which is heterogeneous and reduced by spatial summation. Face-encoding neural activity forms a cluster in similar cortical locations regardless of whether it is defined by early evoked low-frequency signals or late-induced high-gamma signals. By contrast, facial subcategory-encoding activity is distributed, not confined to the face cluster, and dynamically increases its heterogeneity from the early evoked to late-induced phases. These findings support a view that, in contrast to the homogeneous and static coarse category-encoding neural cluster, finer category-encoding clusters are heterogeneously distributed even outside their parent category cluster and dynamically increase heterogeneity along with the local cortical processing in the ITC.

    DOI: 10.1093/cercor/bhx342

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  • Decoding value related signals represented in multiple areas of the prefrontal cortex using ECoG electrodes Reviewed

    Sakagami Masamichi, Tanaka Shingo, Kawasaki Keisuke, Hasegawa Isao, Suzuki Takafumi

    INTERNATIONAL JOURNAL OF PSYCHOLOGY   51   874   2016.7

  • Associative-memory representations emerge as shared spatial patterns of theta activity spanning the primate temporal cortex Reviewed

    Kiyoshi Nakahara, Ken Adachi, Keisuke Kawasaki, Takeshi Matsuo, Hirohito Sawahata, Kei Majima, Masaki Takeda, Sayaka Sugiyama, Ryota Nakata, Atsuhiko Iijima, Hisashi Tanigawa, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa

    NATURE COMMUNICATIONS   7   11827   2016.6

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    DOI: 10.1038/ncomms11827

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  • Hierarchal information dynamics in spatiotemporal activity pattern of inferior temporal cortex revealed by electrocorticography

    Keisuke Kawasaki

    Transactions of Japanese Society for Medical and Biological Engineering   54 ( 28 )   S291 - S291   2016

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    Language:Japanese   Publisher:Japanese Society for Medical and Biological Engineering  

    <p>Converging evidence suggests that cortical processing is performed in a hierarchical manner. In the primate object vision, visual information is thought to be processed along the sequence of areas. We identified the direct physiological evidence for the cortical hierarchical processing as propagating activity patterns by employing electrocorticography (ECoG) in monkey, which enable us to record neural activity from wide cortical areas at high spatiotemporal resolution. Quantification of the propagating wave by symbolic local transfer entropy (SLTE) revealed both feed-forward and feedback components. We also found that SLTE topography changed during the visual stimulation. We also examined hierarchal nature of the process by comparing the ECoG activity pattern with the output from each layer of a deep neural network model. The output explained the specific spatiotemporal aspect of the ECoG activity. These results add the physiological insights of the hierarchical processing in the ventral visual stream.</p>

    DOI: 10.11239/jsmbe.54Annual.S291

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  • Alternating Zones Selective to Faces and Written Words in the Human Ventral Occipitotemporal Cortex Reviewed

    Takeshi Matsuo, Keisuke Kawasaki, Kensuke Kawai, Kei Majima, Hiroshi Masuda, Hiroatsu Murakami, Naoto Kunii, Yukiyasu Kamitani, Shigeki Kameyama, Nobuhito Saito, Isao Hasegawa

    CEREBRAL CORTEX   25 ( 5 )   1265 - 1277   2015.5

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    DOI: 10.1093/cercor/bht319

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  • Decoding visual object categories from temporal correlations of ECoG signals Reviewed

    Kei Majima, Takeshi Matsuo, Keisuke Kawasaki, Kensuke Kawai, Nokihito Saito, Isao Hasegawa, Yukiyasu Kamitani

    NEUROIMAGE   90   74 - 83   2014.4

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    DOI: 10.1016/j.neuroimage.2013.12.020

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  • Super multi-channel recording systems with UWB wireless transmitter for BMI Reviewed

    Takafumi Suzuki, Hiroshi Ando, Takeshi Yoshida, Hirohito Sawahata, Keisuke Kawasaki, Isao Hasegawa, Kojiro Matsushita, Masayuki Hirata, Toshiki Yoshimine, Kenichi Takizawa

    2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)   2014   5208 - 5211   2014

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    DOI: 10.1109/EMBC.2014.6944799

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  • Simultaneous Recording of Single-Neuron Activities and Broad-Area Intracranial Electroencephalography: Electrode Design and Implantation Procedure Reviewed

    Takeshi Matsuo, Kensuke Kawai, Takeshi Uno, Naoto Kunii, Naohisa Miyakawa, Kenichi Usami, Keisuke Kawasaki, Isao Hasegawa, Nobuhito Saito

    NEUROSURGERY   73 ( 2 Suppl Operative )   146 - 154   2013.12

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    DOI: 10.1227/01.neu.0000430327.48387.e1

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  • Super Multi-Channel Recording System for BMI

    Suzuki Takafumi, Ando Hiroshi, Yoshida Takeshi, Sawahata Hirohito, Kawasaki Keisuke, Hasegawa Isao, Matsushita Kojiro, Hirata Masayuki, Yoshimine Toshiki, Takizawa Kenichi

    BME   51   M - 2-M-2   2013

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    DOI: 10.11239/jsmbe.51.M-2

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  • LOCAL AND RETROGRADE GENE TRANSFER INTO PRIMATE NEURONAL PATHWAYS VIA ADENO-ASSOCIATED VIRUS SEROTYPE 8 AND 9 Reviewed

    Y. Masamizu, T. Okada, K. Kawasaki, H. Ishibashi, S. Yuasa, S. Takeda, I. Hasegawa, K. Nakahara

    NEUROSCIENCE   193   249 - 258   2011.10

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    DOI: 10.1016/j.neuroscience.2011.06.080

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  • Intrasulcal electrocorticography in macaque monkeys with minimally invasive neurosurgical protocols Reviewed

    Takeshi Matsuo, Keisuke Kawasaki, Takahiro Osada, Hirohito Sawahata, Takafumi Suzuki, Masahiro Shibata, Naohisa Miyakawa, Kiyoshi Nakahara, Atsuhiko Iijima, Noboru Sato, Kensuke Kawai, Nobuhito Saito, Isao Hasegawa

    Frontiers in Systems Neuroscience   5 ( 2011 )   34   2011.5

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    DOI: 10.3389/fnsys.2011.00034

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  • Intrasulcal ECoG approach to cortico-cortical connectivity using electrical stimulation-induced evoked potentials in macaques Reviewed

    Osada Takahiro, Molcard Antoine J, Matsuo Takeshi, Kawasaki Keisuke, Adachi Yusuke, Miyamoto Kentaro, Watanabe Tomomi, Hasegawa Isao, Miyashita Yasushi

    NEUROSCIENCE RESEARCH   71   E97   2011

  • Intrasulcal electrocorticography in macaque monkeys Reviewed

    Kawasaki Keisuke, Matsuo Takeshi, Osada Takahiro, Sawahata Hirohito, Suzuki Takafumi, Shibata Masahiro, Miyakawa Naohisa, Nakahara Kiyoshi, Sato Noboru, Kawai Kensuke, Saito Nobuhito, Hasegawa Isao

    NEUROSCIENCE RESEARCH   71   E413 - E414   2011

  • Effects of Familiarity on Neural Activity in Monkey Inferior Temporal Lobe Reviewed

    Britt Anderson, Ryan E. B. Mruczek, Keisuke Kawasaki, David Sheinberg

    CEREBRAL CORTEX   18 ( 11 )   2540 - 2552   2008.11

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    DOI: 10.1093/cercor/bhn015

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  • Learning to recognize visual objects with microstimulation in inferior temporal cortex Reviewed

    Keisuke Kawasaki, David L. Sheinberg

    JOURNAL OF NEUROPHYSIOLOGY   100 ( 1 )   197 - 211   2008.7

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    DOI: 10.1152/jn.90247.2008

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  • Effects of long-term object familiarity on event-related potentials in the monkey Reviewed

    Jessie J. Peissig, Jedediah Singer, Keisuke Kawasaki, David L. Sheinberg

    CEREBRAL CORTEX   17 ( 6 )   1323 - 1334   2007.6

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    DOI: 10.1093/cercor/bhl043

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  • Initial saccades predict manual recognition choices in the monkey Reviewed

    David L. Sheinberg, Jessie J. Peissig, Keisuke Kawasaki, Ryan E. B. Mruczek

    VISION RESEARCH   46 ( 22 )   3812 - 3822   2006.10

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    DOI: 10.1016/j.visres.2006.06.009

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  • Presumed inhibitory neurons in the macaque inferior temporal cortex: Visual response properties and functional interactions with adjacent neurons Reviewed

    H Tamura, H Kaneko, K Kawasaki, Fujita, I

    JOURNAL OF NEUROPHYSIOLOGY   91 ( 6 )   2782 - 2796   2004.6

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    DOI: 10.1152/jn.01267.2003

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  • Inhibitory mechanisms underlying stimulus-selective responses of inferior temporal neurons Reviewed

    H Tamura, H Kaneko, K Kawasaki, Fujita, I

    NEURAL BASIS OF EARLY VISION   11   245 - 249   2003

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MISC

  • マカクザルを用いた心の理論の脳基盤研究

    林 剛丞, 江川 純, 川嵜 圭祐, 秋川 諒太, 長谷川 功, 飯島 敦彦, 染矢 俊幸

    新潟医学会雑誌   135 ( 7 )   139 - 139   2021.7

  • Chemogenetic activation of the amygdala specifically disrupts the representation of socio-emotional information in the macaque ventral visual cortex

    Miyakawa N, Nagai Y, Hori Y, Matsuo T, Suzuki T, Inoue K, Takada M, Suhara T, Kawasaki K, Minamimoto T

    2019.7

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  • マカクザルにおける心の理論の検討および内側前頭前野の不活性化によるその関連性について

    林 剛丞, 江川 純, 川崎 圭祐, 秋川 諒太, 長谷川 功, 飯島 淳彦, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S603 - S603   2019.6

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    Language:Japanese   Publisher:(公社)日本精神神経学会  

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  • Decoding recalled color imagery using ECoG signals in macaque inferior temporal and prefrontal cortices

    TANIGAWA Hisashi, TAKEI Ren, MAJIMA Kei, KAWASAKI Keisuke, SAWAHATA Hiroto, NAKAHARA Kiyoshi, SUZUKI Takafumi, KAMIYA Yukiyasu, HASEGAWA Isao

    日本神経回路学会全国大会講演論文集   25th   103   2015.9

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  • Development of ECoG based multi-channel recording BMI system using UWB wireless communications

    ANDO Hiroshi, TAKIZAWA Kenichi, YOSHIDA Takeshi, SAWAHATA Hirohito, KAWASAKI Keisuke, HASEGAWA Isao, MATSUSHITA Kojiro, HIRATA Masayuki, YOSHIMINE Toshiki, SUZUKI Takafumi

    日本生体医工学会大会プログラム・論文集(CD-ROM)   53rd   ROMBUNNO.SY3-03-6 - 78-SY-79   2014

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    Language:English   Publisher:Japanese Society for Medical and Biological Engineering  

    To realize a low-invasive and high accuracy BMI (Brain-machine interface) system, we have already developed a fully-implantable wireless BMI system which consists of ECoG neural electrode arrays, neural recording LSIs, a Wi-Fi based wireless data transmitter and a wireless power receiver with a rechargeable battery. For accurate estimation of movement intentions, it is important for a BMI system to have a large number of recording channels. In this paper, we report a new multi-channel BMI system which is able to record up to 4096ch ECoG data by multiple connections of 64-ch LSIs and time division multiplexing of recorded data. This system has an ultra-wide-band (UWB) wireless unit for transmitting the recorded neural signals to outside the body. By preliminary experiments with a human body equivalent liquid phantom, we confirmed 4096ch UWB wireless data transmission at 128Mbps mode below 25mm distance.

    DOI: 10.11239/jsmbe.52.SY-78

    CiNii Article

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  • 次世代のてんかん発作モニタリング,脳機能評価を目指して

    松尾健, 川合謙介, 宇野健志, 國井尚人, 川嵜圭祐, 宮川尚久, 長谷川功, 斉藤延人

    日本てんかん外科学会プログラム・抄録集   36th   50   2012.12

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    Language:Japanese  

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  • サル下側頭葉皮質の動きの処理について

    中島 啓, 川嵜 圭祐, 澤畑 博人, 鈴木 隆文, 長谷川 功

    Vision   24 ( 3 )   119 - 119   2012.7

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    Language:Japanese   Publisher:日本視覚学会  

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  • 皮質脳波の時間的パターンを用いた視覚物体カテゴリーのデコーディング(Neural decoding of visual object categories using temporal patterns of ECoG signals)

    間島 慶, 松尾 健, 川嵜 圭祐, 川合 謙介, 増田 浩, 國井 尚人, 村上 博淳, 鎌田 恭輔, 亀山 茂樹, 斉藤 延人, 長谷川 功, 神谷 之康

    神経化学   49 ( 2-3 )   724 - 724   2010.8

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    Language:English   Publisher:日本神経化学会  

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  • 皮質脳波を用いた側頭葉視覚領野の機能マッピング(Electrocorticographic mapping of human ventral visual areas)

    松尾 健, 川嵜 圭祐, 川合 謙介, 増田 浩, 國井 尚人, 村上 博淳, 間島 慶, 鎌田 恭輔, 神谷 之康, 亀山 茂樹, 齋藤 延人, 長谷川 功

    神経化学   49 ( 2-3 )   508 - 508   2010.8

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    Language:English   Publisher:日本神経化学会  

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  • Accuracy of Pupil Detection with and without Head Restraints

    KIRYU Yuichiro, IIJIMA Atsuhiko, KAWASAKI Keisuke, MIYAKAWA Naohisa, MAEDA Yoshinobu, HASEGAWA Isao

    IEICE technical report   109 ( 194 )   19 - 22   2009.9

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    Language:Japanese   Publisher:The Institute of Electronics, Information and Communication Engineers  

    Head movement during video oculography is considered as a major source of artifacts. However, little quantitative information is available as to how pupil detection is affected by head motions. Here we show that the accuracy of pupil detection was significantly higher with head fixation devices than without ones in humans. Moreover, a preliminary study in a macaque monkey indicated that some visual targets on a screen or reward apparatus could improve pupil detection under non head-fixated conditions. These results confirmed the importance of had fixation in video oculography.

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  • Visual response properties of presumed inhibitory neurons in the macaque inferior temporal cortex

    TAMURA Hiroshi, KANEKO Hidekazu, KAWASAKI Keisuke, FUJITA Ichiro

    51   96 - 96   2002.8

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Research Projects

  • Neural basis of adaptive decision making and simulation of others in the brain depending on the social contexts

    Grant number:24K09682

    2024.4 - 2027.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

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  • Neural Correlates of Theory of Mind Development

    Grant number:23KK0145

    2023.9 - 2027.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Fund for the Promotion of Joint International Research (International Collaborative Research)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\21060000 ( Direct Cost: \16200000 、 Indirect Cost:\4860000 )

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  • Brain network dynamics for theory of mind

    Grant number:22K07318

    2022.4 - 2025.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

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  • Neural mechanisms of preferential looking for shitsukan

    Grant number:21H05813

    2021.9 - 2023.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Transformative Research Areas (A)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\7540000 ( Direct Cost: \5800000 、 Indirect Cost:\1740000 )

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  • Investigation and manipulation of neural networks for adaptive decision making in competitive and cooperative interactions

    Grant number:21K07258

    2021.4 - 2024.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

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  • The neural basis of "outwitting others": behavioral selection based on simulating others in the brain

    Grant number:18K07349

    2018.4 - 2021.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Tanaka Shingo

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    Although multiple brain areas are involved in “the theory of mind”, the ability to infer the mind of others, the neural process of inferring others which changes with interaction with the self, and the neural basis of action selection according to the inferred others in the brain and the surrounding situation is still unknown. In this study, we developed an interactive experimental task and aimed to elucidate the neurophysiological basis of strategic behavioral selection using simulated others in the brain. First, we performed fMRI experiments to record the brain activity of human subjects. We used a computational behavioral model to explain the behavior of human subjects and explored the brain activity that correlated with the parameters of the model, and found activation in the TPJ and prefrontal cortex. In addition, we developed ECoG electrodes to record neural activity from macaque macaques and trained them to perform the interactive task.

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  • Reactivation of memory representation by pattern stimulation of the brain

    Grant number:17H06268

    2017.6 - 2020.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Challenging Research (Pioneering)

    Awarding organization:Japan Society for the Promotion of Science

    Nakahara Kiyoshi

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    Grant amount:\26000000 ( Direct Cost: \20000000 、 Indirect Cost:\6000000 )

    We attempted to reconstruct visual images from visual responses of electrocorticogram (ECoG) in the monkey primary visual cortex (V1). We also examined ECoG responses to the illusory surface perceived by color filling-in using one kind of the illusory images, "the neon color spreading". We are currently conducting the reconstruction of the visual image using a deep neural network. As a result of analyzing the ECoG responses to the illusory surface, we found visual responses to the perception of the illusory surface between 150 ms and 200 ms after the stimulus onset. The spatial extent of the visual response to the illusory surface in V1 was approximately the same as the visual angle of the perceived illusion in the horizontal direction, while it was more expanded in the vertical direction.

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  • Neural mechanism of hierarchical categorization

    Grant number:16K01959

    2016.4 - 2019.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Kawasaki Keisuke, Suzuki Takafumi, Matsumoto Narihisa

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    Abstraction is a key computing underling our intelligent capacity such as thinking, inference and linguistic activity. However neuronal basis of the cognitive process is largely unknown mainly because a lack of an appropriate animal model which enable us to measure and manipulate the direct neural activity. In this project, thus we developed a hierarchal categorization task for monkeys. We show that two out of the two monkeys learned the hierarchal categorization in which the monkey has to explicitly classify the natural categories with three abstraction levels. We also investigated the neural representation of face and its subcategories. Neural activities were recorded by electrocorticogram, local field potential and multi-unit activity in inferior temporal cortex (ITC). The results suggest that the finer category clusters are heterogeneously distributed even outside their parent category cluster and dynamically increase heterogeneity along with the cortical processing in the ITC.

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  • Deep Representation Learning of Shitsukan Using Vision and Language

    Grant number:15H05919

    2015.6 - 2020.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

    Awarding organization:Japan Society for the Promotion of Science

    Okatani Takayuki

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    Grant amount:\59410000 ( Direct Cost: \45700000 、 Indirect Cost:\13710000 )

    We have obtained step-by-step achievements towards realizing an AI that can recognize the Shitsukan of an object from its single image. We have developed the following methods: i) a CNN-based method for Shitsukan recognition based on learning to rank image pairs; ii) a method for mining visually recognizable Shitsukan concepts from pairs of images and their descriptions on the Web; iii) a method for generating appropriate titles for images of products while capturing the context-aware Shitsukan concepts. The developments of the above lead to the conclusion that Shitsukan recognition is "comprehensive image recognition," and we successfully developed a network with an attention mechanism, which is an offshoot of today's multimodal deep neural networks for image understanding.

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  • Elucidating the autism pathogenesis through brain networks of "theory of mind" and modeling autism in non-human primates

    Grant number:26293261

    2014.4 - 2019.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    Someya Toshiyuki

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    Grant amount:\17680000 ( Direct Cost: \13600000 、 Indirect Cost:\4080000 )

    Human neuroimaging studies using various false-belief (FB) attribution tasks have revealed relationships between theory of mind (ToM) and brain networks, including the medial prefrontal cortex (mPFC). In the present study, we examined whether there was causation between neuronal activity in the macaque mPFC and the spontaneous gaze bias to FB targets. We injected hM4Di, an inhibitory DREADD , into the mPFC. We chemogenetically inactivated the mPFC using clozapine N-oxide, a specific ligand to hM4Di. We found that chemogenetic deactivation of the mPFC with CNO injection in monkeys expressing hM4Di specifically altered the gaze bias to the FB target. Thus, our results indicate that neural activity in the macaque mPFC plays a causal role in ToM. These findings suggest the novel possibility that macaques implicitly attribute mental states to others via the operation of neural circuits that are shared with humans, in which the mPFC plays a pivotal role.

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  • Neural mechanisms of visual communications revealed with electrocorticography.

    Grant number:26242088

    2014.4 - 2017.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (A)

    Awarding organization:Japan Society for the Promotion of Science

    Hasegawa Isao, SUZUKI Takafumi, TODA Haruo, KAWASAKI Keisuke, IIJIMA Atsuhiko, NISHIYAMA Yuta

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    Grant amount:\44850000 ( Direct Cost: \34500000 、 Indirect Cost:\10350000 )

    We developed a method to quantify the information flow of the cerebral cortex as the local transfer entropy from the spatial pattern of the electrocorticographic signals with various dimensions. With this approach, we identified repetitions of forward and backward waves in the macaque inferior temporal cortex following visual stimulation with dynamic topological changes. Next we found that spatial patterns of theta-band powers spanning a wide area in the medial temporal lobe can represent associative memory, which is reorganized through associative learning. In the prefrontal cortex, we identified flows of theta-band powers associated with symbolic conversion and construction. Finally, microstructure of surround suppression was revealed with spatiotemporal two-dimensional fast Fourier transformation of visually evoked signals in the rat visual cortex.

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  • Research on memory retrieval mechanisms in the primate medial temporal lobe using high-density electrocorticography

    Grant number:25282249

    2013.4 - 2017.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    Kiyoshi Nakahara, SAWAHATA Hirohito, ADACHI Ken

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    Grant amount:\19760000 ( Direct Cost: \15200000 、 Indirect Cost:\4560000 )

    Using high-density electrocorticography (ECoG), we investigated local-field potentials spanning the monkey temporal lobes, and found that the visual pair-association memory is encoded in spatial patterns of theta activity in the primate medial temporal lobe.

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  • Spatiotemporal patterns in inferior temporal cortex during visual object recognition probing by wide area brain stimulation

    Grant number:25350997

    2013.4 - 2016.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Kawasaki Keisuke

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    Grant amount:\5070000 ( Direct Cost: \3900000 、 Indirect Cost:\1170000 )

    The inferior temporal cortex (IT) of the monkey plays an essential role in visual object recognition. Neurons in IT encodes visual features for object identification such as shape, color and surface properties. It is still unclear how wide areal activity patterns of the IT contribute the recognition process. In this study we aimed 1) to identify the wide areal activity patterns underlying visual recognition 2) to identify the effect of the perturbation on spatiotemporal activity patterns of IT. We revealed that recognition memory representation emerged as shared spatial patterns of theta activity spanning the IT. We also reveal that the spatiotemporal activity patterns of the IT engaged information flow. The fast oscillation of feedforward and feedback flow was observed. The flow dynamics may reflects hierarchal neuronal information processing. We developed a multichannel simultaneous recording and stimulation system for wide area brain stimulation.

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  • 皮質脳波法による生き物らしい質感の脳内表現の研究

    Grant number:25135716

    2013.4 - 2015.3

    System name:科学研究費助成事業

    Research category:新学術領域研究(研究領域提案型)

    Awarding organization:日本学術振興会

    川嵜 圭祐

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    Grant amount:\10400000 ( Direct Cost: \8000000 、 Indirect Cost:\2400000 )

    視覚に基づいた抽象的なカテゴリはどのような神経メカニズムによって実現されているのでしょうか?ヒトはさまざまな物体に”生き物らしさ”を感じて(アニマシー知覚)、物体を動物と非動物のカテゴリーに大別できます。これまでの研究から特定の動きのパターンや表面のテクスチャパターンなど、この知覚に重要な視覚的物理パラメータや、関連する脳領域が示唆されています。しかし、複数の物理パラメータが知覚に関与する仕組みや複数の関連脳領域がどのように協調してアニマシー知覚を生み出す機序は不明です。視線解析等の行動学的な研究からサルにおいても同様のアニマシー知覚が存在することが示唆されています。そこで本研究では、概念的な質感の動物モデルとしてサルのアニマシー知覚を行動学的、神経科学的に検証することを目的としました。2頭のニホンザルを用いて、動物・非動物の動画の種類に応じて適切な記号を80%以上の成績で正しく選択できるように訓練を行いました。学習達成後、他の新規の動画例でも、記号と動画のカテゴリの割当が汎化するか検討しました。新規の例を導入した場合には初学習に比べて早く基準成績に達し、学習の節約が見られました。また1頭のサルでは初めてみた動画に対しても正しいカテゴリ分けができるようになることがわかりました。これらの結果は条件性反応だけでは説明できず学習の汎化が見られました。また上側頭溝内を含む下側頭葉皮質(ITC)と、内側部を含む前頭葉皮質(PFC)から皮質脳波記録を行い、動物の動き、非生物物体の動きが描出された2秒間の映像を呈示したときの応答を記録しました。 応答振幅はITC,PFCのそれぞれで特徴的な時間経過を示した。個々の刺激動画に対する選択性はどちらの領野でも、幾つかのピークを形成しながら上昇することがわかりました。カテゴリ応答選択性もやはり幾つかのピークを形成していました。

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  • How do autistic people recognize wholeness? From cognitive experiment to a nursing model.

    Grant number:25730167

    2013.4 - 2015.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Young Scientists (B)

    Awarding organization:Japan Society for the Promotion of Science

    NISHIYAMA Yuta, HASEGAWA Isao, KAWASAKI Keisuke, NAGASAWA Masaki, KATO Kimiko

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    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    Our research focused on a human ability to comprehend wholeness of some event. To examine how people develop a semantic formation and modulation, we conducted two experiments. Typical development people (6, 7, 9, 11 year-old children and adults) participated in this study. It was demonstrated that a cognitive mode changed with age. Younger people tend to grasp wholeness of events with collecting individual events. On the other hand, older people tend to grasp them with interpreting a few individual events inductively. They suggest that atypical development people might thoroughly adopt the former cognitive mode. To verify it in detail, future works would require some non-linguistic experiments.

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  • Neural mechanism of flexible cognition and use of symbols: a comparative macaque ECoG and human fMRI study

    Grant number:23300150

    2011.4 - 2014.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    HASEGAWA ISAO, NAKAHARA Kiyoshi, KITAGAWA Junichi, KAWASAKI Keisuke

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    Grant amount:\20150000 ( Direct Cost: \15500000 、 Indirect Cost:\4650000 )

    We developed a visual sign system where object categories were symbolically represented by distinct combinations of visual elements. Macaque monkeys (Macaca fuscata) learned to use these composite symbols by combining and decomposing elements. We conducted multichannel electrtocorticographic (ECoG) recording from the prefrontal cortex and inferior temporal cortex of the monkeys. Analyses of event-related spectral perturbation of the prefrontal ECoG signals revealed areal segregation for combination and decomposition of symbol elements in specific frequency band powers. Functional magnetic resonance imaging in healthy human subjects revealed insular activation during reading particularly when segmentation of letterstrings was required compared to segmentation was not required. Furthermore, we tested symmetry of symbolic use in three macaque monkeys. Symbolic association was symmetrically learned in two macaques but not in one animal, indicating the need for further testing.

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  • 皮質脳波記録法を用いた視覚学習に伴う脳機能マップの可塑性の検証

    Grant number:23135512

    2011.4 - 2013.3

    System name:科学研究費助成事業

    Research category:新学術領域研究(研究領域提案型)

    Awarding organization:日本学術振興会

    川嵜 圭祐

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    Grant amount:\8320000 ( Direct Cost: \6400000 、 Indirect Cost:\1920000 )

    霊長類の大脳皮質下側頭葉には特定の種類の物体の形や色を専門的に処理する部位が存在する。これらの機能モジュールが認知学習を習得する際にどのようなどのような機能的な変化を引き起こしているのか?本研究では大脳皮質の広い領域から長期間にわたり高時空間分解能で記録が可能な皮質脳波(Electrocorticogram(ECoG))法をサル下側頭葉皮質に適用して、質感の知覚、情報処理の経験依存的な側面を明らかにすることを目的に以下の実験を行った。
    ①ECoG法によって上側頭溝を含む下側頭葉皮質の視覚モジュールマップを高い時空間分解能で同定する、②サルが訓練によって、色、形、動きを組み合わせてつくりだされる新規物体カテゴリ学習を習得できるか行動学的に検証する、③学習に伴う機能マップの変化を同定する。
    ①について、下側頭葉皮質での長期ECoG法を確立して、広範囲における視覚応答の伝搬様式を高時空間分解能で可視化することに成功した。視覚応答は、いくつかの速度、方向の異なる神経活動伝搬が複数回繰り返す様子としてとらえられた。先行研究から視覚モジュールは階層的な視覚情報処理によって形成されていくと示唆されてきたが、今回の結果は視覚モジュール形成過程において、階層的処理に加え、動的な繰り返し現象が重要であることを示唆する。また応答の時間周波数解析によって30-100Hz程度の比較的高い周波数成分に形と動きのモジュールが見出されることがわかった。②についてニホンザルに1頭に記号を使った動物・非動物動画のカテゴリ分け課題を訓練することに成功した。初学習の動画セットを学習後、新規動画セットを訓練するとより早くカテゴリ分けを習得することがわかった。③について、見慣れた動画セットと新規動画セットに対する時間周波数応答に差が見いだされた。

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  • Neural activity related to construction of compound images in the macaque prefrontal cortex

    Grant number:20500355

    2008 - 2010

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    HASEGAWA Isao, TODA Haruo, IIJIMA Atsuhiko, KAWASAKI Keisuke

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    Japanese monkeys were trained in a symbolic construction matching-to-sample (SCMS) task in which 6 compound figures symbolically represent 6 objects. Behavioral experiments showed that the monkeys could learn the SCMS task, and generalize from item-object associations to category-object associations. We developed ultra-thin flexible electrode arrays for electrocorticogram (ECoG), and implanted them into the prefrontal cortex of the monkeys. During the SCMS task, ECoG responses to the second sample element was induced earlier and became larger than during sample presentation of a compound figure in a symbolic matching-to-sample task.

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Teaching Experience

  • 生理学実習

    2024
    Institution name:新潟大学

  • 人体の構造と機能I(生理学)

    2024
    Institution name:新潟大学