2022/12/10 更新

写真a

カワサキ ケイスケ
川嵜 圭祐
KAWASAKI Keisuke
所属
教育研究院 医歯学系 医学系列 准教授
医歯学総合研究科 生体機能調節医学専攻 感覚統合医学 准教授
職名
准教授
▶ researchmapのプロフィールを表示
外部リンク

学位

  • 理学 ( 2002年3月   大阪大学 )

  • Doctor(Science) ( 2002年3月   大阪大学 )

  • 神経生理学 ( 1997年3月   大阪大学 )

  • 生物工学 ( 1995年3月   大阪大学 )

研究キーワード

  • 視覚認識

  • 心の理論

  • 包括脳ネットワーク

  • 記憶

  • 学習

研究分野

  • ライフサイエンス / 生理学

経歴(researchmap)

  • 新潟大学   医歯学系   准教授

    2015年4月 - 現在

      詳細を見る

  • 新潟大学 医歯学系   助教

    2010年

      詳細を見る

経歴

  • 新潟大学   医歯学総合研究科 生体機能調節医学専攻 感覚統合医学   准教授

    2015年4月 - 現在

  • 新潟大学   医学部 医学科   助教

    2009年4月 - 2015年3月

  • 新潟大学   医歯学総合研究科 生体機能調節医学専攻 感覚統合医学   助教

    2009年4月 - 2015年3月

 

論文

  • Decoding distributed oscillatory signals driven by memory and perception in the prefrontal cortex

    Hisashi Tanigawa, Kei Majima, Ren Takei, Keisuke Kawasaki, Hirohito Sawahata, Kiyoshi Nakahara, Atsuhiko Iijima, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa

    Cell Reports   39 ( 2 )   110676 - 110676   2022年4月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.celrep.2022.110676

    researchmap

  • Macaques Exhibit Implicit Gaze Bias Anticipating Others' False-Belief-Driven Actions via Medial Prefrontal Cortex. 査読 国際誌

    Taketsugu Hayashi, Ryota Akikawa, Keisuke Kawasaki, Jun Egawa, Takafumi Minamimoto, Kazuto Kobayashi, Shigeki Kato, Yukiko Hori, Yuji Nagai, Atsuhiko Iijima, Toshiyuki Someya, Isao Hasegawa

    Cell reports   30 ( 13 )   4433 - 4444   2020年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The ability to infer others' mental states is essential to social interactions. This ability, critically evaluated by testing whether one attributes false beliefs (FBs) to others, has been considered to be uniquely hominid and to accompany the activation of a distributed brain network. We challenge the taxon specificity of this ability and identify the causal brain locus by introducing an anticipatory-looking FB paradigm combined with chemogenetic neuronal manipulation in macaque monkeys. We find spontaneous gaze bias of macaques implicitly anticipating others' FB-driven actions. Silencing of the medial prefrontal neuronal activity with inhibitory designer receptor exclusively activated by designer drugs (DREADDs) specifically eliminates the implicit gaze bias while leaving the animals' visually guided and memory-guided tracking abilities intact. Thus, neuronal activity in the medial prefrontal cortex could have a causal role in FB-attribution-like behaviors in the primate lineage, emphasizing the importance of probing the neuronal mechanisms underlying theory of mind with relevant macaque animal models.

    DOI: 10.1016/j.celrep.2020.03.013

    PubMed

    researchmap

  • マカクザルにおける他者の誤信念理解に内側前頭前野が因果的役割を果たす

    秋川 諒太, 林 剛丞, 川嵜 圭祐, 江川 純, 南本 敬史, 小林 和人, 加藤 成樹, 堀 由紀子, 永井 裕司, 飯島 淳彦, 染矢 俊幸, 長谷川 功

    日本生理学雑誌   82 ( 1 )   10 - 10   2020年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本生理学会  

    researchmap

  • 硬膜上高密度多点電極を用いたサル一次視覚野における網膜視野の再構成

    土屋 貴大, 飯島 淳彦, 川嵜 圭祐, 鈴木 隆文, 長谷川 功, 中原 潔

    日本生理学雑誌   82 ( 1 )   11 - 12   2020年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本生理学会  

    researchmap

  • 物体素材に対するサル下側頭葉皮質における皮質脳波応答

    三木 治憲, 安斎 健太, 澤山 正貴, 松尾 健, 鈴木 隆文, 岡谷 貴之, 飯島 淳彦, 長谷川 功, 川嵜 圭祐

    日本生理学雑誌   82 ( 1 )   11 - 11   2020年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本生理学会  

    researchmap

  • マカクザルにおける心の理論の検討および内側前頭前野の不活性化によるその関連性について

    林 剛丞, 江川 純, 川崎 圭祐, 秋川 諒太, 長谷川 功, 飯島 淳彦, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S603 - S603   2019年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本精神神経学会  

    researchmap

  • Deep Learning for Natural Image Reconstruction from Electrocorticography Signals.

    Hiroto Date, Keisuke Kawasaki, Isao Hasegawa, Takayuki Okatani

    2331 - 2336   2019年

     詳細を見る

    掲載種別:研究論文(国際会議プロシーディングス)  

    DOI: 10.1109/BIBM47256.2019.8983029

    researchmap

    その他リンク: https://dblp.uni-trier.de/db/conf/bibm/bibm2019.html#DateKHO19

  • Locally induced neuronal synchrony precisely propagates to specific cortical areas without rhythm distortion 査読

    Haruo Toda, Keisuke Kawasaki, Sho Sato, Masao Horie, Kiyoshi Nakahara, Asim K. Bepari, Hirohito Sawahata, Takafumi Suzuki, Haruo Okado, Hirohide Takebayashi, Isao Hasegawa

    Scientific Reports   8 ( 1 )   7678   2018年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nature Publishing Group  

    Propagation of oscillatory spike firing activity at specific frequencies plays an important role in distributed cortical networks. However, there is limited evidence for how such frequency-specific signals are induced or how the signal spectra of the propagating signals are modulated during across-layer (radial) and inter-areal (tangential) neuronal interactions. To directly evaluate the direction specificity of spectral changes in a spiking cortical network, we selectively photostimulated infragranular excitatory neurons in the rat primary visual cortex (V1) at a supra-threshold level with various frequencies, and recorded local field potentials (LFPs) at the infragranular stimulation site, the cortical surface site immediately above the stimulation site in V1, and cortical surface sites outside V1. We found a significant reduction of LFP powers during radial propagation, especially at high-frequency stimulation conditions. Moreover, low-gamma-band dominant rhythms were transiently induced during radial propagation. Contrastingly, inter-areal LFP propagation, directed to specific cortical sites, accompanied no significant signal reduction nor gamma-band power induction. We propose an anisotropic mechanism for signal processing in the spiking cortical network, in which the neuronal rhythms are locally induced/modulated along the radial direction, and then propagate without distortion via intrinsic horizontal connections for spatiotemporally precise, inter-areal communication.

    DOI: 10.1038/s41598-018-26054-8

    Scopus

    PubMed

    researchmap

  • Heterogeneous Redistribution of Facial Subcategory Information Within and Outside the Face-Selective Domain in Primate Inferior Temporal Cortex. 査読 国際誌

    Naohisa Miyakawa, Kei Majima, Hirohito Sawahata, Keisuke Kawasaki, Takeshi Matsuo, Naoki Kotake, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa

    Cerebral cortex (New York, N.Y. : 1991)   28 ( 4 )   1416 - 1431   2018年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The inferior temporal cortex (ITC) contains neurons selective to multiple levels of visual categories. However, the mechanisms by which these neurons collectively construct hierarchical category percepts remain unclear. By comparing decoding accuracy with simultaneously acquired electrocorticogram (ECoG), local field potentials (LFPs), and multi-unit activity in the macaque ITC, we show that low-frequency LFPs/ECoG in the early evoked visual response phase contain sufficient coarse category (e.g., face) information, which is homogeneous and enhanced by spatial summation of up to several millimeters. Late-induced high-frequency LFPs additionally carry spike-coupled finer category (e.g., species, view, and identity of the face) information, which is heterogeneous and reduced by spatial summation. Face-encoding neural activity forms a cluster in similar cortical locations regardless of whether it is defined by early evoked low-frequency signals or late-induced high-gamma signals. By contrast, facial subcategory-encoding activity is distributed, not confined to the face cluster, and dynamically increases its heterogeneity from the early evoked to late-induced phases. These findings support a view that, in contrast to the homogeneous and static coarse category-encoding neural cluster, finer category-encoding clusters are heterogeneously distributed even outside their parent category cluster and dynamically increase heterogeneity along with the local cortical processing in the ITC.

    DOI: 10.1093/cercor/bhx342

    PubMed

    researchmap

  • Decoding value related signals represented in multiple areas of the prefrontal cortex using ECoG electrodes 査読

    Sakagami Masamichi, Tanaka Shingo, Kawasaki Keisuke, Hasegawa Isao, Suzuki Takafumi

    INTERNATIONAL JOURNAL OF PSYCHOLOGY   51   874   2016年7月

  • Associative-memory representations emerge as shared spatial patterns of theta activity spanning the primate temporal cortex 査読

    Kiyoshi Nakahara, Ken Adachi, Keisuke Kawasaki, Takeshi Matsuo, Hirohito Sawahata, Kei Majima, Masaki Takeda, Sayaka Sugiyama, Ryota Nakata, Atsuhiko Iijima, Hisashi Tanigawa, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa

    NATURE COMMUNICATIONS   7   11827   2016年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATURE PUBLISHING GROUP  

    Highly localized neuronal spikes in primate temporal cortex can encode associative memory; however, whether memory formation involves area-wide reorganization of ensemble activity, which often accompanies rhythmicity, or just local microcircuit-level plasticity, remains elusive. Using high-density electrocorticography, we capture local-field potentials spanning the monkey temporal lobes, and show that the visual pair-association (PA) memory is encoded in spatial patterns of theta activity in areas TE, 36, and, partially, in the parahippocampal cortex, but not in the entorhinal cortex. The theta patterns elicited by learned paired associates are distinct between pairs, but similar within pairs. This pattern similarity, emerging through novel PA learning, allows a machine-learning decoder trained on theta patterns elicited by a particular visual item to correctly predict the identity of those elicited by its paired associate. Our results suggest that the formation and sharing of widespread cortical theta patterns via learning-induced reorganization are involved in the mechanisms of associative memory representation.

    DOI: 10.1038/ncomms11827

    Web of Science

    PubMed

    researchmap

  • 皮質脳波法で見た下側頭葉皮質の階層的な視覚情報処理ネットワーク

    川嵜 圭祐

    生体医工学   54 ( 28 )   S291 - S291   2016年

     詳細を見る

    記述言語:日本語   出版者・発行元:一般社団法人 日本生体医工学会  

    <p>Converging evidence suggests that cortical processing is performed in a hierarchical manner. In the primate object vision, visual information is thought to be processed along the sequence of areas. We identified the direct physiological evidence for the cortical hierarchical processing as propagating activity patterns by employing electrocorticography (ECoG) in monkey, which enable us to record neural activity from wide cortical areas at high spatiotemporal resolution. Quantification of the propagating wave by symbolic local transfer entropy (SLTE) revealed both feed-forward and feedback components. We also found that SLTE topography changed during the visual stimulation. We also examined hierarchal nature of the process by comparing the ECoG activity pattern with the output from each layer of a deep neural network model. The output explained the specific spatiotemporal aspect of the ECoG activity. These results add the physiological insights of the hierarchical processing in the ventral visual stream.</p>

    DOI: 10.11239/jsmbe.54Annual.S291

    CiNii Article

    researchmap

  • Alternating Zones Selective to Faces and Written Words in the Human Ventral Occipitotemporal Cortex 査読

    Takeshi Matsuo, Keisuke Kawasaki, Kensuke Kawai, Kei Majima, Hiroshi Masuda, Hiroatsu Murakami, Naoto Kunii, Yukiyasu Kamitani, Shigeki Kameyama, Nobuhito Saito, Isao Hasegawa

    CEREBRAL CORTEX   25 ( 5 )   1265 - 1277   2015年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS INC  

    Recognition of faces and written words is associated with category-specific brain activation in the ventral occipitotemporal cortex (vOT). However, topological and functional relationships between face-selective and word-selective vOT regions remain unclear. In this study, we collected data from patients with intractable epilepsy who underwent high-density recording of surface field potentials in the vOT. "Faces" and "letterstrings" induced outstanding category-selective responses among the 24 visual categories tested, particularly in high-gamma band powers. Strikingly, within-hemispheric analysis revealed alternation of face-selective and letterstring-selective zones within the vOT. Two distinct face-selective zones located anterior and posterior portions of the mid-fusiform sulcus whereas letterstring-selective zones alternated between and outside of these 2 face-selective zones. Further, a classification analysis indicated that activity patterns of these zones mostly represent dedicated categories. Functional connectivity analysis using Granger causality indicated asymmetrically directed causal influences from face-selective to letterstring-selective regions. These results challenge the prevailing view that different categories are represented in distinct contiguous regions in the vOT.

    DOI: 10.1093/cercor/bht319

    Web of Science

    PubMed

    researchmap

  • Decoding visual object categories from temporal correlations of ECoG signals 査読

    Kei Majima, Takeshi Matsuo, Keisuke Kawasaki, Kensuke Kawai, Nokihito Saito, Isao Hasegawa, Yukiyasu Kamitani

    NEUROIMAGE   90   74 - 83   2014年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    How visual object categories are represented in the brain is one of the key questions in neuroscience. Studies on low-level visual features have shown that relative timings or phases of neural activity between multiple brain locations encode information. However, whether such temporal patterns of neural activity are used in the representation of visual objects is unknown. Here, we examined whether and how visual object categories could be predicted (or decoded) from temporal patterns of electrocorticographic (ECoG) signals from the temporal cortex in five patients with epilepsy. We used temporal correlations between electrodes as input features, and compared the decoding performance with features defined by spectral power and phase from individual electrodes. While using power or phase alone, the decoding accuracy was significantly better than chance, correlations alone or those combined with power outperformed other features. Decoding performance with correlations was degraded by shuffling the order of trials of the same category in each electrode, indicating that the relative time series between electrodes in each trial is critical. Analysis using a sliding time window revealed that decoding performance with correlations began to rise earlier than that with power. This earlier increase in performance was replicated by a model using phase differences to encode categories. These results suggest that activity patterns arising from interactions between multiple neuronal units carry additional information on visual object categories. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.neuroimage.2013.12.020

    Web of Science

    PubMed

    researchmap

  • Super multi-channel recording systems with UWB wireless transmitter for BMI 査読

    Takafumi Suzuki, Hiroshi Ando, Takeshi Yoshida, Hirohito Sawahata, Keisuke Kawasaki, Isao Hasegawa, Kojiro Matsushita, Masayuki Hirata, Toshiki Yoshimine, Kenichi Takizawa

    2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)   2014   5208 - 5211   2014年

     詳細を見る

    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:IEEE  

    In order to realize a low-invasive and high accuracy Brain-Machine Interface (BMI) system for clinical applications, a super multi-channel recording system was developed in which 4096 channels of Electrocorticogram (ECoG) signal can be amplified and transmitted to outside the body by using an Ultra Wide Band (UWB) wireless system. Also, a high density, flexible electrode array made by using a Parylene-C substrate was developed that is composed of units of 32-ch recording arrays. We have succeeded in an evaluation test of UWB wireless transmitting using a body phantom system.

    DOI: 10.1109/EMBC.2014.6944799

    Web of Science

    PubMed

    researchmap

  • Simultaneous Recording of Single-Neuron Activities and Broad-Area Intracranial Electroencephalography: Electrode Design and Implantation Procedure 査読

    Takeshi Matsuo, Kensuke Kawai, Takeshi Uno, Naoto Kunii, Naohisa Miyakawa, Kenichi Usami, Keisuke Kawasaki, Isao Hasegawa, Nobuhito Saito

    NEUROSURGERY   73 ( 2 Suppl Operative )   146 - 154   2013年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    BACKGROUND: There has been growing interest in clinical single-neuron recording to better understand epileptogenicity and brain function. It is crucial to compare this new information, single-neuronal activity, with that obtained from conventional intracranial electroencephalography during simultaneous recording. However, it is difficult to implant microwires and subdural electrodes during a single surgical operation because the stereotactic frame hampers flexible craniotomy.
    OBJECTIVE: To describe newly designed electrodes and surgical techniques for implanting them with subdural electrodes that enable simultaneous recording from hippocampal neurons and broad areas of the cortical surface.
    METHODS: We designed a depth electrode that does not protrude into the dura and pulsates naturally with the brain. The length and tract of the depth electrode were determined preoperatively between the lateral subiculum and the lateral surface of the temporal lobe. A frameless navigation system was used to insert the depth electrode. Surface grids and ventral strips were placed before and after the insertion of the depth electrodes, respectively. Finally, a microwire bundle was inserted into the lumen of the depth electrode. We evaluated the precision of implantation, the recording stability, and the recording rate with microwire electrodes.
    RESULTS: Depth-microwire electrodes were placed with a precision of 3.6 mm. The mean successful recording rate of single-or multiple-unit activity was 14.8%, which was maintained throughout the entire recording period.
    CONCLUSION: We achieved simultaneous implantation of microwires, depth electrodes, and broad-area subdural electrodes. Our method enabled simultaneous and stable recording of hippocampal single-neuron activities and multichannel intracranial electroencephalography.

    DOI: 10.1227/01.neu.0000430327.48387.e1

    Web of Science

    PubMed

    researchmap

  • Super Multi-Channel Recording System for BMI

    Suzuki Takafumi, Ando Hiroshi, Yoshida Takeshi, Sawahata Hirohito, Kawasaki Keisuke, Hasegawa Isao, Matsushita Kojiro, Hirata Masayuki, Yoshimine Toshiki, Takizawa Kenichi

    生体医工学   51   M - 2-M-2   2013年

     詳細を見る

    記述言語:英語   出版者・発行元:Japanese Society for Medical and Biological Engineering  

    DOI: 10.11239/jsmbe.51.M-2

    CiNii Article

    researchmap

  • LOCAL AND RETROGRADE GENE TRANSFER INTO PRIMATE NEURONAL PATHWAYS VIA ADENO-ASSOCIATED VIRUS SEROTYPE 8 AND 9 査読

    Y. Masamizu, T. Okada, K. Kawasaki, H. Ishibashi, S. Yuasa, S. Takeda, I. Hasegawa, K. Nakahara

    NEUROSCIENCE   193   249 - 258   2011年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Viral vector-mediated gene transfer has become increasingly valuable for primate brain research, in particular for application of genetic methods (e.g. optogenetics) to study neuronal circuit functions. Neuronal cell tropisms and infection patterns are viable options for obtaining viral vector-mediated transgene delivery that is selective for particular neuronal pathways. For example, several types of viral vectors can infect axon terminals (retrograde infections), which enables targeted transgene delivery to neurons that directly project to a particular viral injection region. Although recent studies in rodents have demonstrated that adeno-associated virus serotype 8 (AAV8) and 9 (AAV9) efficiently transduce neurons, the tropisms and infection patterns remain poorly understood in primate brains. Here, we constructed recombinant AAV8 or AAV9, which expressed an enhanced green fluorescent protein (EGFP) gene driven by a ubiquitous promoter (AAV8-EGFP and AAV9-EGFP, respectively), and stereotaxically injected it into several brain regions in marmosets and macaque monkeys. Immunohistochemical analyses revealed almost exclusive colocalization of EGFP fluorescence via AAV9-mediated gene transfer with a neuron-specific marker, indicating endogenous neuronal tropism of AAV9, which was consistent with our previous results utilizing AAV8. Injections of either AAV8-EGFP or AAV9-EGFP into the marmoset striatum resulted in EGFP expression in local striatal neurons as a result of local infection, as well as expression in dopaminergic neurons of the substantia nigra via retrograde transport along nigrostriatal axonal projections. Retrograde infections were also observed in the frontal cortex and thalamus, which are known to have direct projections to the striatum. These local and retrograde gene transfers were further demonstrated in the geniculocortical pathway of the marmoset visual system. These findings indicate promising capabilities of AAV8 and AAV9 to deliver molecular tools into a range of primate neural systems in pathway-specific manners through their neuronal tropisms and infection patterns. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.neuroscience.2011.06.080

    Web of Science

    PubMed

    researchmap

  • LOCAL AND RETROGRADE GENE TRANSFER INTO PRIMATE NEURONAL PATHWAYS VIA ADENO-ASSOCIATED VIRUS SEROTYPE 8 AND 9 査読

    Y. Masamizu, T. Okada, K. Kawasaki, H. Ishibashi, S. Yuasa, S. Takeda, I. Hasegawa, K. Nakahara

    NEUROSCIENCE   193   249 - 258   2011年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Viral vector-mediated gene transfer has become increasingly valuable for primate brain research, in particular for application of genetic methods (e.g. optogenetics) to study neuronal circuit functions. Neuronal cell tropisms and infection patterns are viable options for obtaining viral vector-mediated transgene delivery that is selective for particular neuronal pathways. For example, several types of viral vectors can infect axon terminals (retrograde infections), which enables targeted transgene delivery to neurons that directly project to a particular viral injection region. Although recent studies in rodents have demonstrated that adeno-associated virus serotype 8 (AAV8) and 9 (AAV9) efficiently transduce neurons, the tropisms and infection patterns remain poorly understood in primate brains. Here, we constructed recombinant AAV8 or AAV9, which expressed an enhanced green fluorescent protein (EGFP) gene driven by a ubiquitous promoter (AAV8-EGFP and AAV9-EGFP, respectively), and stereotaxically injected it into several brain regions in marmosets and macaque monkeys. Immunohistochemical analyses revealed almost exclusive colocalization of EGFP fluorescence via AAV9-mediated gene transfer with a neuron-specific marker, indicating endogenous neuronal tropism of AAV9, which was consistent with our previous results utilizing AAV8. Injections of either AAV8-EGFP or AAV9-EGFP into the marmoset striatum resulted in EGFP expression in local striatal neurons as a result of local infection, as well as expression in dopaminergic neurons of the substantia nigra via retrograde transport along nigrostriatal axonal projections. Retrograde infections were also observed in the frontal cortex and thalamus, which are known to have direct projections to the striatum. These local and retrograde gene transfers were further demonstrated in the geniculocortical pathway of the marmoset visual system. These findings indicate promising capabilities of AAV8 and AAV9 to deliver molecular tools into a range of primate neural systems in pathway-specific manners through their neuronal tropisms and infection patterns. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.neuroscience.2011.06.080

    Web of Science

    PubMed

    researchmap

  • Intrasulcal electrocorticography in macaque monkeys with minimally invasive neurosurgical protocols 査読

    Takeshi Matsuo, Keisuke Kawasaki, Takahiro Osada, Hirohito Sawahata, Takafumi Suzuki, Masahiro Shibata, Naohisa Miyakawa, Kiyoshi Nakahara, Atsuhiko Iijima, Noboru Sato, Kensuke Kawai, Nobuhito Saito, Isao Hasegawa

    Frontiers in Systems Neuroscience   5 ( 2011 )   34   2011年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Electrocorticography (ECoG), multichannel brain-surface recording and stimulation with probe electrode arrays, has become a potent methodology not only for clinical neurosurgery but also for basic neuroscience using animal models. The highly evolved primate's brain has deep cerebral sulci, and both gyral and intrasulcal cortical regions have been implicated in important functional processes. However, direct experimental access is typically limited to gyral regions, since placing probes into sulci is difficult without damaging the surrounding tissues. Here we describe a novel methodology for intrasulcal ECoG in macaque monkeys. We designed and fabricated ultra-thin flexible probes for macaques with micro-electro-mechanical systems (MEMS) technology. We developed minimally invasive operative protocols to implant the probes by introducing cutting edge devices for human neurosurgery. To evaluate the feasibility of intrasulcal ECoG, we conducted electrophysiological recording and stimulation experiments. First, we inserted parts of the Parylene-C-based probe into the superior temporal sulcus to compare visually evoked ECoG responses from the ventral bank of the sulcus with those from the surface of the inferior temporal cortex. Analyses of power spectral density and signal-to-noise ratio revealed that the quality of the ECoG signal was comparable inside and outside of the sulcus. Histological examination revealed no obvious physical damage in the implanted areas. Second, we placed a modified silicone ECoG probe into the central sulcus and also on the surface of the precentral gyrus for stimulation. Thresholds for muscle twitching were significantly lower during intrasulcal stimulation compared to gyral stimulation. These results demonstrate the feasibility of intrasulcal ECoG in macaques. The novel methodology proposed here opens up a new frontier in neuroscience research, enabling the direct measurement and manipulation of electrical activity in the whole brain. © 2011 Matsuo, Kawasaki, Osada, Sawahata, Suzuki, Shibata, Miyakawa, Nakahara, Iijima, Sato, Kawai, Saito and Hasegawa.

    DOI: 10.3389/fnsys.2011.00034

    Scopus

    PubMed

    researchmap

  • Intrasulcal ECoG approach to cortico-cortical connectivity using electrical stimulation-induced evoked potentials in macaques 査読

    Osada Takahiro, Molcard Antoine J, Matsuo Takeshi, Kawasaki Keisuke, Adachi Yusuke, Miyamoto Kentaro, Watanabe Tomomi, Hasegawa Isao, Miyashita Yasushi

    NEUROSCIENCE RESEARCH   71   E97   2011年

  • Intrasulcal electrocorticography in macaque monkeys 査読

    Kawasaki Keisuke, Matsuo Takeshi, Osada Takahiro, Sawahata Hirohito, Suzuki Takafumi, Shibata Masahiro, Miyakawa Naohisa, Nakahara Kiyoshi, Sato Noboru, Kawai Kensuke, Saito Nobuhito, Hasegawa Isao

    NEUROSCIENCE RESEARCH   71   E413 - E414   2011年

  • Effects of Familiarity on Neural Activity in Monkey Inferior Temporal Lobe 査読

    Britt Anderson, Ryan E. B. Mruczek, Keisuke Kawasaki, David Sheinberg

    CEREBRAL CORTEX   18 ( 11 )   2540 - 2552   2008年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS INC  

    Long-term familiarity facilitates recognition of visual stimuli. To better understand the neural basis for this effect, we measured the local field potential (LFP) and multiunit spiking activity (MUA) from the inferior temporal (IT) lobe of behaving monkeys in response to novel and familiar images. In general, familiar images evoked larger amplitude LFPs whereas MUA responses were greater for novel images. Familiarity effects were attenuated by image rotations in the picture plane of 45 degrees. Decreasing image contrast led to more pronounced decreases in LFP response magnitude for novel, compared with familiar images, and resulted in more selective MUA response profiles for familiar images. The shape of individual LFP traces could be used for stimulus classification, and classification performance was better for the familiar image category. Recording the visual and auditory evoked LFP at multiple depths showed significant alterations in LFP morphology with distance changes of 2 mm. In summary, IT cortex shows local processing differences for familiar and novel images at a time scale and in a manner consistent with the observed behavioral advantage for classifying familiar images and rapidly detecting novel stimuli.

    DOI: 10.1093/cercor/bhn015

    Web of Science

    PubMed

    researchmap

  • Learning to recognize visual objects with microstimulation in inferior temporal cortex 査読

    Keisuke Kawasaki, David L. Sheinberg

    JOURNAL OF NEUROPHYSIOLOGY   100 ( 1 )   197 - 211   2008年7月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER PHYSIOLOGICAL SOC  

    The malleability of object representations by experience is essential for adaptive behavior. It has been hypothesized that neurons in inferior temporal cortex (IT) in monkeys are pivotal in visual association learning, evidenced by experiments revealing changes in neural selectivity following visual learning, as well as by lesion studies, wherein functional inactivation of IT impairs learning. A critical question remaining to be answered is whether IT neuronal activity is sufficient for learning. To address this question directly, we conducted experiments combining visual classification learning with microstimulation in IT. We assessed the effects of IT microstimulation during learning in cases where the stimulation was exclusively informative, conditionally informative, and informative but not necessary for the classification task. The results show that localized microstimulation in IT can be used to establish visual classification learning, and the same stimulation applied during learning can predictably bias judgments on subsequent recognition. The effect of induced activity can be explained neither by direct stimulation- motor association nor by simple detection of cortical stimulation. We also found that the learning effects are specific to IT stimulation as they are not observed by microstimulation in an adjacent auditory area. Our results add the evidence that the differential activity in IT during visual association learning is sufficient for establishing new associations. The results suggest that experimentally manipulated activity patterns within IT can be effectively combined with ongoing visually induced activity during the formation of new associations.

    DOI: 10.1152/jn.90247.2008

    Web of Science

    PubMed

    researchmap

  • Effects of long-term object familiarity on event-related potentials in the monkey 査読

    Jessie J. Peissig, Jedediah Singer, Keisuke Kawasaki, David L. Sheinberg

    CEREBRAL CORTEX   17 ( 6 )   1323 - 1334   2007年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS INC  

    Although some change in the neural representation of an object must occur as it becomes familiar, the nature of this change is not fully understood. In humans, it has been shown that the N170 - an evoked visual potential-is enhanced for classes of objects for which people have visual expertise. In this study, we explored whether monkeys show a similar modulation in event-related potential (ERP) amplitude as a result of long-term familiarity by recording ERPs with chronically implanted electrodes over extended training periods spanning many sessions. In each of 3 experiments, we found larger amplitude visual evoked responses to highly familiar images for the time period of 120-250 ms after stimulus onset. This difference was found when the monkeys were trained in an individual-level discrimination task, in a task that required only color discrimination, and even following a viewing-only task. We thus observed this familiarity effect across several tasks and different object categories and further found that the difference between "familiar" and "novel" became smaller as the animals gained experience with the previously unfamiliar objects across multiple test sessions. These data suggest that changes in visual responses associated with familiarity are evident early in the evoked visual response, are robust, and may be automatic, driven at least in part by repeated object exposure.

    DOI: 10.1093/cercor/bhl043

    Web of Science

    PubMed

    researchmap

  • Initial saccades predict manual recognition choices in the monkey 査読

    David L. Sheinberg, Jessie J. Peissig, Keisuke Kawasaki, Ryan E. B. Mruczek

    VISION RESEARCH   46 ( 22 )   3812 - 3822   2006年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    In animals with specialized foveae, eye position has a direct influence over the acquisition of detailed visual information. At the same time, eye movements executed during natural behaviors are closely linked with motor actions. In this study, we investigated patterns of eye movements during a simple visual discrimination task. Three rhesus monkeys learned to recognize images of real world objects with no explicit constraints on eye position. Analysis of the monkeys' eye movements showed that although the endpoint of the initial saccade depended on the particular visual stimulus, the trajectory of the first saccades also reliably predicted the manual response associated with that stimulus. We thus observed that initial saccades executed in a recognition task reflect both perceptual and motor aspects of a visual task. This pattern of eye movements emerged spontaneously in all three animals tested despite the fact that saccades were never explicitly rewarded. As the average saccade latency was under 200 ms, object specific learned associations must have exerted their influence over the initial saccade even earlier, providing a novel temporal marker for the rapidity of visual recognition processes. Taken together, these results suggest that caution should be exercised when interpreting the meaning of oculomotor patterns observed during perceptual tasks, as these blur the line between perceptual processing and motor preparation. (c) 2006 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.visres.2006.06.009

    Web of Science

    PubMed

    researchmap

  • Presumed inhibitory neurons in the macaque inferior temporal cortex: Visual response properties and functional interactions with adjacent neurons 査読

    H Tamura, H Kaneko, K Kawasaki, Fujita, I

    JOURNAL OF NEUROPHYSIOLOGY   91 ( 6 )   2782 - 2796   2004年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER PHYSIOLOGICAL SOC  

    Neurons in area TE of the monkey inferior temporal cortex respond selectively to images of particular objects or their characteristic visual features. The mechanism of generation of the stimulus selectivity, however, is largely unknown. This study addresses the role of inhibitory TE neurons in this process by examining their visual response properties and interactions with adjacent target neurons. We applied cross-correlation analysis to spike trains simultaneously recorded from pairs of adjacent neurons in anesthetized macaques. Neurons whose activity preceded a decrease in activity from their partner were presumed to be inhibitory neurons. Excitatory neurons were also identified as the source neuron of excitatory linkage as evidenced by a sharp peak displaced from the 0-ms bin in cross-correlograms. Most inhibitory neurons responded to a variety of visual stimuli in our stimulus set, which consisted of several dozen geometrical figures and photographs of objects, with a clear stimulus preference. On average, 10% of the stimuli increased firing rates of the inhibitory neurons. Both excitatory and inhibitory neurons exhibited a similar degree of stimulus selectivity. Although inhibitory neurons occasionally shared the most preferred stimuli with their target neurons, overall stimulus preferences were less similar between adjacent neurons with inhibitory linkages than adjacent neurons with common inputs and/or excitatory linkages. These results suggest that inhibitory neurons in area TE are activated selectively and exert stimulus-specific inhibition on adjacent neurons, contributing to shaping of stimulus selectivity of TE neurons.

    DOI: 10.1152/jn.01267.2003

    Web of Science

    PubMed

    researchmap

  • Inhibitory mechanisms underlying stimulus-selective responses of inferior temporal neurons 査読

    H Tamura, H Kaneko, K Kawasaki, Fujita, I

    NEURAL BASIS OF EARLY VISION   11   245 - 249   2003年

     詳細を見る

    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:SPRINGER-VERLAG TOKYO  

    Web of Science

    researchmap

  • Inhibitory long-term potentiation underlies auditory conditioning of goldfish escape behaviour 査読

    Y Oda, K Kawasaki, M Morita, H Korn, H Matsui

    NATURE   394 ( 6689 )   182 - 185   1998年7月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MACMILLAN MAGAZINES LTD  

    Long-term potentiation (LTP), the increase in synaptic strength evoked by high-frequency stimulation, is often considered to be a cellular model for learning and memory. The validity of this model depends on the assumptions that physiological stimuli can induce LTP in vivo and that the resulting: synaptic modifications correlate with behavioural changes. However, modifiable synapses are generally embedded deep in complex circuits. In contrast, the goldfish Mauthner (M)-cell and its afferent synapses are easily accessible for electrophysiological studies, and firing of this neuron is sufficient to trigger fast escape behaviour in response to sudden stimuli(1,2). We have previously shown that tetanic stimulation can induce LTP of the feedforward inhibitory synapses that control the excitability of the M-ceIl(3,4). Here we report that natural sensory stimulation can induce potentiation of this inhibitory connection that resembles the LTP induced by afferent tetanization. Furthermore, comparable acoustic stimulation produced a parallel decrease in the probability of the sound-evoked escape reflex Thus we demonstrate for the first time, to our knowledge, a behavioural role for the long-term synaptic strengthening of inhibitory synapses.

    DOI: 10.1038/28172

    Web of Science

    PubMed

    CiNii Article

    researchmap

▶ 全件表示

MISC

  • Chemogenetic activation of the amygdala specifically disrupts the representation of socio-emotional information in the macaque ventral visual cortex

    Miyakawa N, Nagai Y, Hori Y, Matsuo T, Suzuki T, Inoue K, Takada M, Suhara T, Kawasaki K, Minamimoto T

    第42回日本神経科学大会(朱鷺メッセ、新潟市)   2019年7月

     詳細を見る

    記述言語:英語  

    researchmap

  • マカクザルにおける心の理論の検討および内側前頭前野の不活性化によるその関連性について

    林 剛丞, 江川 純, 川崎 圭祐, 秋川 諒太, 長谷川 功, 飯島 淳彦, 染矢 俊幸

    精神神経学雑誌   ( 2019特別号 )   S603 - S603   2019年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本精神神経学会  

    researchmap

  • Decoding recalled color imagery using ECoG signals in macaque inferior temporal and prefrontal cortices

    TANIGAWA Hisashi, TAKEI Ren, MAJIMA Kei, KAWASAKI Keisuke, SAWAHATA Hiroto, NAKAHARA Kiyoshi, SUZUKI Takafumi, KAMIYA Yukiyasu, HASEGAWA Isao

    日本神経回路学会全国大会講演論文集   25th   103   2015年9月

     詳細を見る

    記述言語:英語  

    J-GLOBAL

    researchmap

  • Development of ECoG based multi-channel recording BMI system using UWB wireless communications

    ANDO Hiroshi, TAKIZAWA Kenichi, YOSHIDA Takeshi, SAWAHATA Hirohito, KAWASAKI Keisuke, HASEGAWA Isao, MATSUSHITA Kojiro, HIRATA Masayuki, YOSHIMINE Toshiki, SUZUKI Takafumi

    日本生体医工学会大会プログラム・論文集(CD-ROM)   53rd   ROMBUNNO.SY3-03-6   2014年

     詳細を見る

    記述言語:英語  

    J-GLOBAL

    researchmap

  • 次世代のてんかん発作モニタリング,脳機能評価を目指して

    松尾健, 川合謙介, 宇野健志, 國井尚人, 川嵜圭祐, 宮川尚久, 長谷川功, 斉藤延人

    日本てんかん外科学会プログラム・抄録集   36th   50   2012年12月

     詳細を見る

    記述言語:日本語  

    J-GLOBAL

    researchmap

  • サル下側頭葉皮質の動きの処理について

    中島 啓, 川嵜 圭祐, 澤畑 博人, 鈴木 隆文, 長谷川 功

    Vision   24 ( 3 )   119 - 119   2012年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:日本視覚学会  

    researchmap

  • 皮質脳波の時間的パターンを用いた視覚物体カテゴリーのデコーディング(Neural decoding of visual object categories using temporal patterns of ECoG signals)

    間島 慶, 松尾 健, 川嵜 圭祐, 川合 謙介, 増田 浩, 國井 尚人, 村上 博淳, 鎌田 恭輔, 亀山 茂樹, 斉藤 延人, 長谷川 功, 神谷 之康

    神経化学   49 ( 2-3 )   724 - 724   2010年8月

     詳細を見る

    記述言語:英語   出版者・発行元:日本神経化学会  

    researchmap

  • 皮質脳波を用いた側頭葉視覚領野の機能マッピング(Electrocorticographic mapping of human ventral visual areas)

    松尾 健, 川嵜 圭祐, 川合 謙介, 増田 浩, 國井 尚人, 村上 博淳, 間島 慶, 鎌田 恭輔, 神谷 之康, 亀山 茂樹, 齋藤 延人, 長谷川 功

    神経化学   49 ( 2-3 )   508 - 508   2010年8月

     詳細を見る

    記述言語:英語   出版者・発行元:日本神経化学会  

    researchmap

  • 頭部固定の有無がビデオ方式による視線位置計測に与える影響

    木竜 雄一郎, 飯島 淳彦, 川嵜 圭祐, 宮川 尚久, 前田 義信, 長谷川 功

    電子情報通信学会技術研究報告. MBE, MEとバイオサイバネティックス   109 ( 194 )   19 - 22   2009年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:一般社団法人電子情報通信学会  

    我々は実験動物に対する侵襲を低減し,頭部非固定による行動実験の実現を目指している.本研究では,松田ら(BPES2000他)が過去に開発した高速楕円近似アルゴリズムによるビデオ眼球運動解析システムを利用して,ヒトの眼球運動を頭部固定した場合及び頭部非固定の場合で計測をした.また,ニホンザルの頭部非固定での眼球運動の計測を試みた.それぞれの方法から得られたビデオ画像より瞳孔が検出される確度を検証し,頭部非固定の動物でビデオ方式による視線位置計測が可能か否か検討した.

    CiNii Article

    CiNii Books

    researchmap

▶ 全件表示