Updated on 2024/05/01

写真a

 
KURATA Shigenobu
 
Organization
Academic Assembly Institute of Medicine and Dentistry SHIGAKU KEIRETU Assistant Professor
Faculty of Dentistry Department of Dentistry Assistant Professor
Graduate School of Medical and Dental Sciences Oral Life Science Tissue Regeneration and Reconstruction Assistant Professor
Title
Assistant Professor
External link

Degree

  • 博士(歯学) ( 2007.3   新潟大学 )

Research Areas

  • Life Science / Surgical dentistry

Research History

  • Niigata University   Faculty of Dentistry School of Dentistry   Assistant Professor

    2009.7

  • Niigata University   Graduate School of Medical and Dental Sciences Oral Life Science Tissue Regeneration and Reconstruction   Assistant Professor

    2009.7

Qualification acquired

  • Dentist

  • 日本歯科麻酔学会歯科麻酔専門医

  • 日本歯科麻酔学会認定医

  • 日本障害者歯科学会認定医

 

Papers

  • Unexpected airway foreign body during general anesthesia. Reviewed International journal

    Naotaka Kishimoto, Yutaka Tanaka, Shigenobu Kurata, Kenji Seo

    Journal of dental anesthesia and pain medicine   24 ( 2 )   137 - 138   2024.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.17245/jdapm.2024.24.2.137

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  • 新潟大学医歯学総合病院歯科麻酔科における最近4年間の外来新患患者の動向 Reviewed

    倉田 行伸, 岸本 直隆, 田中 裕, 金丸 博子, 山本 徹, 佐藤 由美子, 今井 有蔵, 小山 祐平, 氏田 倫章, 沢田 詠見, 瀬尾 憲司

    新潟歯学会雑誌   53 ( 2 )   65 - 71   2024.1

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    Language:Japanese   Publisher:新潟歯学会  

    新潟大学医歯学総合病院歯科麻酔科の最近の外来新患患者の動向を調査し,10年前の状況との比較および新型コロナウイルス感染症拡大前後の比較を行うことで今後の歯科麻酔に対する需要について検討した。外来新患患者数は2019年で129名,2020年で108名,2021年で101名,2022年で86名であった。2011年は117名であり,2019年の患者数は増加した。しかし,2020年と2022年に患者数の減少が認められた。2020年の減少は障害者および非協力児の全身麻酔依頼の患者数の減少が要因であった。これは新型コロナウイルス感染症の拡大で歯科治療が延期を余儀なくされたことが考えられた。また,2022年の減少は上記に加え,口腔外科から紹介される患者の減少が要因であり,特に術後の三叉神経障害とペイン(その他)の紹介が減少した。しかし,全体の三叉神経障害の症例数は減少しなかった。これは院外からの紹介が増加傾向にあることに起因すると考えられた。歯科麻酔に対する需要にも変化が生じ,障害者および非協力児の全身麻酔の需要が増加した。また,痛みや知覚障害の診察,治療に対しては院外からの紹介が増加していることから今後も需要は多いことが予想された。(著者抄録)

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  • GAD-7による口腔顔面痛患者の不安の調査 Reviewed

    田中 裕, 瀬尾 憲司, 倉田 行伸, 村松 公美子, 村松 芳幸

    慢性疼痛   42 ( 1 )   50 - 56   2023.12

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    Language:Japanese   Publisher:日本慢性疼痛学会  

    【目的】GAD-7を用いて口腔顔面痛初診患者の不安を調査するとともに,本病態における不安と身体症状との関連性について検討を行った。【対象および方法】事前に本調査の同意が得られた口腔顔面痛初診患者278名を対象として不安などの心理的特性,痛みなどの身体症状,および健康関連QOLを調査し比較検討を行った。【結果および考察】GAD-7の調査結果より,口腔顔面痛患者は比較的高い不安を有しており,不安と抑うつは有意に正の高い相関関係を示していた。さらに不安を有する患者は"痛み"などの身体症状を合併しており,さらに"身体化傾向"が有意に存在していることが示唆された。【結後】調査結果より,口腔顔面痛患者に対してGAD-7を用いて不安の評価を行うことは,本病態の"抑うつ状態","痛み","身体化傾向"など"不安"に伴って生じる心理的・身体的症状の合併を予測するための有用な評価ツールとなりうる可能性が示唆された。(著者抄録)

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  • 上下顎骨形成術後の鎮痛薬使用状況に関する後方視的研究

    倉田 行伸, 岸本 直隆, 田中 裕, 金丸 博子, 山本 徹, 佐藤 由美子, 今井 有蔵, 小山 祐平, 氏田 倫章, 沢田 詠見, 瀬尾 憲司

    日本歯科麻酔学会雑誌   51 ( 抄録号 )   156 - 156   2023.9

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    Language:Japanese   Publisher:(一社)日本歯科麻酔学会  

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  • 気管挿管時に気管狭窄が認められたダウン症候群患者の全身麻酔経験 Reviewed

    氏田 倫章, 山本 徹, 田中 裕, 倉田 行伸, 瀬尾 憲司

    日本歯科麻酔学会雑誌   51 ( 2 )   30 - 32   2023.4

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    19歳女。中等度知的障害があり、通法下での歯科治療が困難であったため、全身麻酔下での歯科治療目的で当院に紹介された。治療は2回行い、1回目の全身麻酔の気管挿管において声門通過後に気管チューブ挿管困難を認め、気管狭窄であることが判明した。そこで2回目の全身麻酔では気管挿管の際、気管狭窄部の形態評価が可能なCT画像をもとに声門から狭窄部までの距離を計測し、狭窄部の上方でチューブ留置することで、気道管理を円滑に行うことができた。

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    Other Link: https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J01093&link_issn=&doc_id=20230703250002&doc_link_id=%2Feq9shika%2F2023%2F005102%2F002%2F0030-0032%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Feq9shika%2F2023%2F005102%2F002%2F0030-0032%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 当科の卒前臨床実習でのビデオ・シミュレーション実習における学生への効果

    倉田 行伸, 岸本 直隆, 田中 裕, 弦巻 立, 金丸 博子, 山本 徹, 瀬尾 憲司

    日本歯科麻酔学会雑誌   50 ( 抄録号 )   198 - 198   2022.9

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  • 自動カフ圧コントローラSmartCuffによりカフ損傷を早期に発見しえた1症例 Reviewed

    今井 有蔵, 岸本 直隆, 倉田 行伸, 田中 裕, 弦巻 立, 金丸 博子, 山本 徹, 瀬尾 憲司

    日本歯科麻酔学会雑誌   50 ( 3 )   122 - 124   2022.7

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    症例は23歳女性で、顎変形症に対して上顎Le Fort I型骨切り術および両側下顎枝矢状分割術が予定された。手術室入室後、プロポフォールTCIで入眠を得たのち、レミフェンタニル塩酸塩、フェンタニルクエン酸塩を投与し、ロクロニウム臭化物にて筋弛緩を得た。右側鼻腔から内径7.0mmの気管チューブを挿入した。気管チューブを声門へ誘導することが困難であったため、マギル鉗子で気管チューブの先端を把持し、補助者にチューブを押してもらうことで声門へ誘導し、気管内へ挿入した。気管挿管から約10分後、気管チューブのパイロットバルーンを、自動カフ圧コントローラであるSmartCuffに接続し、カフ圧を28cmH2Oに設定したところ、カフ圧が21cmH2O以上に上昇せずアラームが鳴った。SmartCuffとパイロットバルーンの接続を解除したのち、手動カフ圧計を用いてカフ圧の調整を試みたが、カフ圧は10cmH2O程度までしか上昇しなかった。カフの損傷を疑って気管チューブを抜管し、別の同型の内径6.5mmの気管チューブを再度挿管した。その結果、リーク音は聴取されず、術中にカフ圧低下を示唆する所見は認められなかった。術後に最初に挿管した内径7.0mmの気管チューブを確認したところ、先端に近いカフ部分に約1mmの損傷が認められた。次にチューブ先端を水中に浸漬した状態でカフに空気を注入すると、カフの損傷部位から空気が排出される様子が観察された。

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    Other Link: https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J01093&link_issn=&doc_id=20220804470002&doc_link_id=10.24569%2Fjjdsa.50.3_122&url=https%3A%2F%2Fdoi.org%2F10.24569%2Fjjdsa.50.3_122&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • 新潟大学医歯学総合病院における最近13年間の院内歯科救急体制の分析 Reviewed

    田中 裕, 弦巻 立, 倉田 行伸, 金丸 博子, 佐藤 由美子, 岸本 直隆, 瀬尾 憲司

    新潟歯学会雑誌   52 ( 1 )   19 - 27   2022.6

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    今回、2007年4月から2020年3月までの13年間に新潟大学医歯学総合病院歯科外来において発生し、当科に出動要請のあった院内救急症例(全身的偶発症発生症例)および歯科外来における院内救急体制について後ろ向きに調査検討を行った。13年間に当科に出動要請のあった院内救急症例は全64例(発生率0.0034%)で、発生頻度は平均4.9例/年であった。症例の最低年齢は12歳、最高年齢は94歳、性別は男性31例(48.4%)、女性33例(51.6%)であった。年齢層は症例全体では20歳代が17例(26.6%)と最も多く、次いで60歳代が10例(15.6%)と多かった。全身的偶発症の診断は血管迷走神経反射が34例(53.1%)と多く、次いで過換気症候群が8例(12.5%)と多かった。また発生患者のうち循環器疾患など基礎疾患を有している患者は55例(85.9%)を占めていた。発生原因は局所麻酔によるものが最も多く、当科救急処置後に症状がほぼ全例で改善傾向がみられていたが、当科処置後に内科など医科を受診指示したものは37例(57.8%)であった。本病院では院内迅速対応システム(Rapid Response System(以下、RRS))が2020年8月に正式発足しているが、本システムは入院病棟における救急処置を主たる業務としていることから、歯科外来において発生する全身的偶発症の対応は原則含まない。従って、歯科麻酔医および口腔外科医が、救急処置の初期対応を迅速に行い、二次救命処置へとスムーズに移行させる役割を担っていくことが今後も重要であると考えられる。加えて、歯科医師、歯科衛生士、さらにはその他の歯科外来スタッフや学生などに対しての全身管理教育、医療安全教育、および院内救急の教育・啓蒙活動を行っていくことは歯科麻酔科の重要な責務であると考えられた。(著者抄録)

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  • Effectiveness of Low-dose Opioid Administration during Intravenous Sedation in a Patient with a Chemical Dependence on a Medical Narcotic Analgesic : A Case Report Reviewed

    SATOH Yumiko, TANAKA Yutaka, KANEMARU Hiroko, TSURUMAKI Tatsuru, KURATA Shigenobu, NISHIDA Yohei, IMAI Yuzo, KOYAMA Yuhei, SEO Kenji

    Journal of Japanese Dental Society of Anesthesiology   47 ( 1 )   16 - 18   2019.1

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    Language:Japanese   Publisher:一般社団法人 日本歯科麻酔学会  

    <p>  We report a case of intravenous sedation using an opioid in a patient with a chemical dependence on a medical narcotic analgesic.</p><p>  A 77-year-old man with rheumatoid arthritis had used an analgesic (TRAMSET<sup>®</sup>) containing tramadol hydrochloride and acetaminophen for intractable chronic pain for a long period of time. Because he had used the analgesic as an anti-anxiety drug and a sleep-inducing drug, we were concerned that he might be chemically dependent on the opioid.</p><p>  A sequestrectomy of the mandible was planned. Because he had experienced discomfort while receiving local anesthetic injections during previous dental treatments, intravenous sedation was scheduled for his operation. During the first attempt at intravenous sedation, midazolam and propofol were used to manage the sedation. When the operation began, the patient began to act out, resulting in an unrested condition. We then stopped the sedation and the operation was postponed. His state of unrest was suspected to have arisen from intense pain. On our second attempt at sedation, we used a sufficient dose of a narcotic analgesic. We provided sufficient local anesthesia, and we tried to relieve the postoperative pain by adding acetaminophen. As a result, the patient was free from any discomfort and intractable pain.</p><p>  Insufficient analgesia and sedation are known to trigger addiction to opioids ; thus, adequate analgesic use during surgery is critical for patient management, even if a patient has a possible chemical dependency. The present case suggests that anesthesiologists should observe the behavior of patients with possible chemical dependencies and should take such behavior into consideration when selecting the analgesic type and administration dose.</p>

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  • Effectiveness of Low-dose Opioid Administration during Intravenous Sedation in a Patient with a Chemical Dependence on a Medical Narcotic Analgesic : A Case Report Reviewed

    佐藤由美子, 田中裕, 金丸博子, 弦巻立, 倉田行伸, 西田洋平, 今井有蔵, 小山祐平, 瀬尾憲司

    日本歯科麻酔学会雑誌(Web)   47 ( 1 )   2019

  • Endotracheal Intubation Complicated by a Palatal Tooth in a Patient With Treacher Collins Syndrome. Reviewed International journal

    Kanemaru H, Tsurumaki T, Kurata S, Tanaka Y, Yoshikawa H, Sato Y, Kodama Y, Suda A, Yamada Y, Seo K

    Anesthesia progress   66 ( 1 )   42 - 43   2019

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    We report a case of difficult endotracheal intubation in a patient with Treacher Collins syndrome. A sixteen-year-old female patient scheduled for general anesthesia had a displaced palatal tooth that interfered with laryngoscope insertion into the pharyngeal space. To address this problem, we successfully performed endotracheal intubation using a fiberscope while elevating the epiglottic vallecula using a King Vision™ video laryngoscope. A later operation was performed after tooth extraction without difficult laryngoscopy. Our experience stresses the importance of removing obstructions to laryngoscopic inspection prior to general anesthesia.

    DOI: 10.2344/anpr-66-02-01

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  • 歯科麻酔科医が緩和ケアチームへ参加することの役割について Reviewed

    佐藤 由美子, 田中 裕, 弦巻 立, 倉田 行伸, 吉川 博之, 金丸 博子, 小玉 由記, 須田 有紀子, 瀬尾 憲司

    日本歯科麻酔学会雑誌   46 ( 2 )   102 - 104   2018.4

  • 口蓋の転位歯が挿管操作を困難にしたTreacher-Collins症候群患者の1例 Reviewed

    金丸 博子, 弦巻 立, 倉田 行伸, 田中 裕, 吉川 博之, 佐藤 由美子, 小玉 由記, 須田 有紀子, 山田 友里恵, 瀬尾 憲司

    日本歯科麻酔学会雑誌   46 ( 2 )   89 - 91   2018.4

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    患者は生下時にTreacher-Collins症候群および両側性唇顎口蓋裂を指摘され、1歳時に口唇形成術、2歳時に口蓋形成術が行われていた。16歳時、口蓋形成術後に生じた口蓋部骨欠損のため、全身麻酔下での腸骨移植術が予定された。日本麻酔科学会のガイドラインで術前予測危険クラスIIIであり、気道確保に注意しながら緩徐導入を行い、気管挿管補助器具を使用して気管挿管する方針とした。酸素・亜酸化窒素・セボフルランで緩徐導入を行い、入眠させたところ気道閉塞が生じ、経鼻エアウェイを使用し気道確保を行った。麻酔を深くしようとしたところ自発呼吸がすぐに消失したため、用手マスク換気を行った。ロクロニウム臭化物を投与し筋弛緩を得た後、エアウェイスコープの挿入を試みたが、イントロックが口蓋の転位歯に当たり挿入できなかった。薄型イントロックに変更したものの困難であり、ビデオ喉頭鏡KINGVISIONを使用したところ挿入可能であったが、可動域が制限されたため

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  • Another Potential Roles of Dental Anesthesiologist in Palliative Care Reviewed

    佐藤由美子, 佐藤由美子, 田中裕, 弦巻立, 倉田行伸, 吉川博之, 金丸博子, 小玉由記, 須田有紀子, 瀬尾憲司

    日本歯科麻酔学会雑誌(Web)   46 ( 2 )   102‐104(J‐STAGE)   2018

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  • Case Report of a Displaced Tooth in the Palate Causing a Difficult Endotracheal Intubation in a Patient with Treacher-Collins Syndrome Reviewed

    金丸博子, 弦巻立, 倉田行伸, 田中裕, 吉川博之, 佐藤由美子, 小玉由記, 須田有紀子, 山田友里恵, 瀬尾憲司

    日本歯科麻酔学会雑誌(Web)   46 ( 2 )   89‐91(J‐STAGE)   2018

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  • High-contrast high-resolution imaging of posttraumatic mandibular nerve by 3DAC-PROPELLER magnetic resonance imaging: correlation with the severity of sensory disturbance Reviewed

    Makoto Terumitsu, Hitoshi Matsuzawa, Kenji Seo, Masaki Watanabe, Shigenobu Kurata, Akiko Suda, Tsutomu Nakada

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY   124 ( 1 )   85 - 94   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Objective. Magnetic resonance neurography reveals abnormal morphologies of regenerated nerves and overgrown connective tissue in injured trigeminal nerves, suggesting neuroma formation. We hypothesized that such deformities and scar formation contribute to pain symptoms.
    Study Design. High-contrast high-resolution magnetic resonance imaging was utilized to evaluate the inferior alveolar nerve and lingual nerve following traumatic injury in 19 patients. The relationship between the morphologic classification and severity of the sensory disorder was assessed.
    Results. In all cases, 3-dimensional anisotropy contrast periodically rotated overlapping parallel lines with enhanced reconstruction (3DAC-PROPELLER) successfully revealed the inner structures within the lesion. The isolated type represented the normal course of the nerve isolated from scar-like tissue (8 cases), whereas the deformity type included the deformed nerve either within scar-like tissue or by itself, unassociated with surrounding scar-like tissue (9 cases). In the remaining 2 cases, the nerve tissue and scar-like tissue were incorporated. Patients with the deformity type exhibited significantly more severe pain symptoms compared with patients with the isolated type.
    Conclusions. Overgrown connective tissue does not necessarily block regenerating nerves and itself may not cause pain. The morphologic findings on the 3DAC-PROPELLER were relevant to the severity of pain symptoms.

    DOI: 10.1016/j.oooo.2017.02.017

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  • 当院における障害者(児)の歯科治療に対する静脈内鎮静法と日帰り全身麻酔の選択の傾向 Reviewed

    倉田行伸, 田中裕, 弦巻立, 金丸博子, 瀬尾憲司

    障害者歯科   38 ( 1 )   74‐79 - 79   2017.2

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  • 術後せん妄対策として抑肝散を予防投与した1例 Reviewed

    弦巻立, 照光真, 山田友里恵, 山崎麻衣子, 金丸博子, 吉川博之, 倉田行伸, 田中裕, 瀬尾憲司

    日本歯科麻酔学会雑誌   42 ( 5 )   636 - 637   2014.10

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    J-GLOBAL

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  • 急性心不全発作を頻発する小児のたこつぼ型心筋症患者の歯科治療時の全身麻酔経験 Reviewed

    田中裕, 倉田行伸, 齊藤陽子, 照光真, 弦巻立, 瀬尾憲司

    日本歯科麻酔学会雑誌   42 ( 3 )   303 - 304   2014.7

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  • Protracted delay in taste sensation recovery after surgical lingual nerve repair: A case report Reviewed

    Kenji Seo, Yuji Inada, Makoto Terumitsu, Tatsuo Nakamura, Keiji Shigeno, Yutaka Tanaka, Tatsuru Tsurumaki, Shigenobu Kurata, Hitoshi Matsuzawa

    Journal of Medical Case Reports   7   77   2013

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    Introduction. Lingual nerve injury is sometimes caused by dental treatment. Many kinds of treatment have been reported, but many have exhibited poor recovery. Here the authors report changes in somatosensory and chemosensory impairments during a long-term observation after lingual nerve repair. Case presentation. A 30-year-old Japanese woman claimed dysesthesia and difficulty eating. Quantitative sensory test results indicated complete loss of sensation in the right side of her tongue. She underwent a repair surgery involving complete resection of her lingual nerve using a polyglycolic acid tube containing collagen 9 months after the injury. A year after the operation, her mechanical touch threshold recovered, but no other sensations recovered. Long-term observation of her somatosensory and chemosensory function after the nerve repair suggested that recovery of taste sensation was greatly delayed compared with that of somatosensory function. Conclusion: This case shows characteristic changes in somatosensory and chemosensory recoveries during 7 postoperative years and suggests that taste and thermal sensations require a very long time to recover after repair surgery. © 2013 Seo et al.
    licensee BioMed Central Ltd.

    DOI: 10.1186/1752-1947-7-77

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  • Criterion for determining the prognosis of reduction in the mechanical touch threshold caused by trigeminal peripheral nerve injury Reviewed

    倉田行伸, 田中裕, 照光真, 弦巻立, 金丸博子, 吉川博之, 小玉由記, 山崎麻衣子, 瀬尾憲司

    日本ペインクリニック学会誌   20 ( 2 )   93-97 (J-STAGE) - 97   2013

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  • Retrospective statistical analysis on the amount of outward patients at the Dental Anesthesia Clinic, Niigata University Medical and Dental Hospital in 2011 Reviewed

    山崎麻衣子, 照光真, 田中裕, 弦巻立, 倉田行伸, 金丸博子, 吉川博之, 小玉由記, 瀬尾憲司

    新潟歯学会雑誌   42 ( 2 )   107 - 111   2012.12

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  • 新潟大学医歯学総合病院での歯科麻酔科管理による全身麻酔下障害者歯科治療の現況 Reviewed

    弦巻立, 照光真, 田中裕, 倉田行伸, 小玉由記, 山崎麻衣子, 金丸博子, 吉川博之, 瀬尾憲司

    新潟歯学会雑誌   42 ( 1 )   65 - 66   2012.6

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  • Retrospective analysis of accidental cases which required in-Hospital Emergency medical system (Dental Call) and evaluation of this system utility at Niigata University Medical and Dental Hospital Reviewed

    田中裕, 照光真, 弦巻立, 倉田行伸, 金丸博子, 吉川博之, 小玉由記, 山崎麻衣子, 瀬尾憲司

    新潟歯学会雑誌   42 ( 1 )   41 - 49   2012.6

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  • プリフォームド気管チューブが曲部で狭窄した2症例 Reviewed

    弦巻立, 山崎麻衣子, 照光真, 田中裕, 倉田行伸, 瀬尾憲司

    臨床麻酔(真興交易)   36 ( 6 )   954 - 956   2012.6

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  • 簡易型熱温度閾値測定装置の開発 Reviewed

    瀬尾憲司, 照光真, 田中裕, 弦巻立, 倉田行伸, 小玉由記, 金丸博子, 山崎麻衣子, 吉川博之, 加藤康憲

    ペインクリニック   33 ( 4 )   569 - 572   2012.4

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  • Preoperative Evaluation of Spatial Relationship Between Inferior Alveolar Nerve and Fibro-osseous Lesion by High Resolution Magnetic Resonance Neurography on 3.0-T System: A Case Report Reviewed

    Kenji Seo, Makoto Terumistu, Yutaka Tanaka, Tatsuru Tsurumaki, Shigenobu Kurata, Hitoshi Matsuzawa, Ritsuo Takagi

    JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY   70 ( 2 )   E119 - E123   2012.2

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    DOI: 10.1016/j.joms.2011.10.004

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  • 感冒回復後の健康成人の全身麻酔で気管支痙攣が発生し喘息様気道過敏性亢進を示した症例 Reviewed

    金丸博子, 田中裕, 照光真, 弦巻立, 倉田行伸, 瀬尾憲司

    臨床麻酔(真興交易)   36 ( 2 )   237 - 238   2012.2

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  • 歯学部登院前における麻酔計画立案実習の歯科麻酔学教育効果に関する考察 Reviewed

    瀬尾憲司, 照光真, 田中裕, 弦巻立, 倉田行伸

    日本歯科麻酔学会雑誌   40 ( 1 )   31 - 35   2012.1

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  • 上顎嚢胞摘出術の全身麻酔中に発生した換気困難がアナフィラキシー反応によると思われた1症例 Reviewed

    近藤由記, 弦巻立, 長谷川麻衣子, 吉川博之, 塚田博子, 倉田行伸, 田中裕, 照光真, 瀬尾憲司

    日本歯科麻酔学会雑誌   39 ( 5 )   652 - 653   2011.10

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  • 口腔外科術後にACTH‐ADH放出症候群発作を認めた1例 Reviewed

    弦巻立, 吉川博之, 倉田行伸, 田中裕, 瀬尾憲司

    日本歯科麻酔学会雑誌   39 ( 2 )   224 - 225   2011.4

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  • 急激な心拍上昇から悪性高熱症を疑い,ダントロレンが奏効したと推察された症例 Reviewed

    倉田行伸, 塚田博子, 弦巻立, 瀬尾憲司, 田中裕, 豊里晃, 染矢源治

    日本歯科麻酔学会雑誌   37 ( 2 )   213 - 214   2009.4

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  • Intravenous Propofol Sedation on Swallowing Reflex and its Relationship with Respiratory and Circulatory Function Reviewed

    倉田行伸, 豊里晃, 瀬尾憲司, 染矢源治

    日本歯科麻酔学会雑誌   35 ( 3 )   354 - 364   2007.7

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  • The Effect of the Postural Change of a Dental Chair on Blood Pressure and Pulse Rate in Relation to Age Reviewed

    豊里晃, 倉田行伸, 前川孝治, 石井多恵子, 岡部香織, 田中裕, 瀬尾憲司, 染矢源治

    日本歯科麻酔学会雑誌   33 ( 3 )   433 - 438   2005.7

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MISC

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Presentations

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Awards

  • 日本ペインクリニック学会誌優秀論文賞 原著臨床部門

    2014.7   日本ペインクリニック学会   末梢性三叉神経損傷における触覚閾値低下の予後判定基準について

    倉田 行伸

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  • 中久喜学術賞

    2008.10   日本歯科麻酔学会   プロポフォール静脈内鎮静法における嚥下反射の抑制に関する研究‐呼吸・循環動態との関係を含めて‐

    倉田 行伸

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Research Projects

  • Central Sensitization for Neuropathic Pain in Trigeminal Nerve-Modulation of Infra-slow Oscillation

    Grant number:18K09821

    2018.4 - 2021.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    TERUMITSU Makoto

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    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    Central sensitization is one of factors which amplifies pain in the central nervous system and exacerbates chronic pain in the orofacial region. We measured metabolites and neural activity in thalamus and anterior cingulate cortex (ACC) where the trigeminal nerve connected to the cortices and controlled unpleasant emotion of pain, respectively. Excitatory and inhibitory neurotransmitters increased in ACC, and correlated with the central sensitization inventory score in patient. Coherent neural activities between the two brain regions were modulated in patient. The current investigation indicated one aspect of brain function associated with central sensitization.

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  • 下歯槽神経の神経障害性疼痛における神経虚血の関与‐MRAとNIRSでの血流検索‐

    2016.4

    System name:科学研究費助成事業 基盤研究(C)

    Awarding organization:日本学術振興会

    倉田 行伸

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  • In vivo imagimg for macrophage subtypes associated with neuropathic pain.

    Grant number:15K11308

    2015.4 - 2018.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Terumitsu Makoto, KOMAKI Yuji, KURATA Shigenobu, YAMAZAKI Maiko

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    Abnormal nerve regeneration after traumatic nerve injury is responsible for neuropathic pain. Pathological neuroinflammation is thought to persist in the disordered nerve. We hypothesized that some subtypes of macrophage are involved in this process, which exacerbates inflammation or enhances tissue regeneration. We established a rat model of neuropathic pain in the trigeminal nerve. A phagocytic macrophage ingests ultra-small iron particles administered systemically as a contrast agent. Thereafter, 7.0T MRI was used to observe the activation of the phagocytic macrophage in the chronic phase of nerve injury. The results suggest that a subtype of macrophage caused to enhance excessive tissue growth responsive to the inflammation, and was involved in pathological nerve regeneration.

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  • ヒト神経障害性疼痛に神経炎症はあるのか?‐in vivo 神経イメージングでの検討

    2013.4 - 2016.3

    System name:科学研究費助成事業 若手研究(B)

    Awarding organization:日本学術振興会

    倉田 行伸

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  • Fundamental study on the modulation mechanism of orofacial pain by the taste and olfactory sensations and its application to clinical use.

    Grant number:24593053

    2012.4 - 2015.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    TANAKA Yutaka, SEO Kenji, TERUMITSU Makoto, YAMAMURA Kensuke, KURATA Shigenobu, YOSHIKAWA Hiroyuki

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    Grant amount:\5330000 ( Direct Cost: \4100000 、 Indirect Cost:\1230000 )

    The aim of this study was to examine the possibility of reduction of orofacial pain and to investigate the modulation mechanism of orofacial pain by the taste and olfactory stimulation.The subjects of this study were patients with chronic orofacial pain that treaded in our department.All the subjects underwent gustatory test and olfactometric tests,and were evaluated with self-answerd type pain score(VAS), various psychological tests, autonomic activity analysis, and near-infrared spectroscopy.As a result, in all the subjects, orofacial pain intensity didn’t change by olfactory test. On the other hand, gustatory test by sweet taste decreased pain intensity(VAS)transient in the glossalgia patients.This study suggest that the sweet taste stimulation may have a transient pain reduction mechanism of glossalgia among orofacial pain.

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  • Analysis of pain induced mechanism after trigeminal nerve injury

    Grant number:23390461

    2011.4 - 2015.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    SEO KENJI, MAEDA Takeyasu, FUJIWARA Naoshi, TERUMITSU Makoto, TSURUMAKI Tatsuru, TANAKA Yutaka, YOSHIKAWA Hiroyuki, KURATA Shigenobu

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    Grant amount:\18200000 ( Direct Cost: \14000000 、 Indirect Cost:\4200000 )

    When peripheral nerve is injured, the some local factors can be produced and affect the regeneration. Brain derived neurotrophic factor BDNFwas released from fibroblasts in the vicinity of the injury site, and its quantity increased within 24 hours after the incidence of injury and decreased after that, resulting in the disappearance. When this BDNF was inactivated at the local site immediately after the injury, elongation of neurites and reconnection of the injured axons were inhibited. This inactivation also inhibited regeneration of mechanical touch sensation, and allodynia, which appeared after the nerve injury, was inhibited. As another factor, the existence of nerve growth inhibitory protein semaphoring-3A was observed after the nerve injury. These results suggested that local facilitator and inhibitory factors are induced at the local site of nerve injury, and these can affect the regeneration, resulting in the prognosis.

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  • Magnetic Resonance Pathology Imaging in vivo based on State of Water Molecule for Peripheral Nerve Disorder in Human Orofacial Region.

    Grant number:23592984

    2011.4 - 2015.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    TERUMITSU Makoto, MATSUZAWA Hitoshi, SEO Kenji, TANAKA Yutaka, TSURUMAKI Tatsuru, KURATA Shigenobu

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    Grant amount:\5330000 ( Direct Cost: \4100000 、 Indirect Cost:\1230000 )

    In order to visualize human peripheral nerve disorder noninvasively, two high-resolution MRI methods, namely, high spatial- and contrast-resolution imaging were established and applied in a clinical setting in this investigation. The imaging successfully delineated the morphologies associated with abnormally regenerated nerve and overgrown scar tissue in patients with chronic neuropathic pain in the trigeminal nerve. The current imaging is considered to reflect pathological nerve histology, and may contribute a diagnosis and a decision on the course of treatments for trigeminal neuropathy.

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  • Is GABAA receptor involved in trigeminal nociceptive transmission?

    Grant number:20390511

    2008 - 2010

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    SEO Kenji, FUJIWARA Naoshi, MAEDA Takeyasu, TSURUMAKI Tatsuru, TSUKADA Hiroko, TANAKA Yutaka, YOSHIKAWA Hiroyuki, KURATA Shigenobu

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    Grant amount:\17550000 ( Direct Cost: \13500000 、 Indirect Cost:\4050000 )

    Introduction ; This project aimed to investigate the possible involvement of GABAA receptor mediated nociceptive modulation in the spinal or trigeminal dorsal horn. We used PRIP-1, PRIP-2 double knockout mice (DKO) which deficits some GAGAA receptor function.
    Method and results : Immnunohistochemical study exhibited a complete deficit in γ2 subunit of GABAA receptor on cell surface of the superficial and deep magnocellular layers in spinal cord of DKO mice. The MAC of wild or DKO animal was 1.36±0.04% (n=10) or 1.07±0.01% (n=10), respectively (Student's t-test, p<0.001). These results suggest that the stimulation of γ2 subunit might did not induce anti-nociceptive effect. Thirdly, spatial and temporal propagation of membrane potential and the changes in the intra- cellular calcium concentration in the slice of medulla exhibited the similar propagation between in the wild and DKO animals and furthermore a perfusion of the highly-selective GABAA receptor agonist muscimol did not induce any difference in these propagation features. The preconditioning by BDNF induced some difference in afferent stimulation induced changes in membrane potential propagation under muscimol perfusion.
    Conclusion ; these results suggest that GABAA receptor does not have any significant role in modulation of nociceptive transmission in normal condition but some stimuli induce BDNF releasing might have some modulating effect on this transmission feature.

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Teaching Experience

  • 歯科衛生士臨床実習III

    2022
    Institution name:新潟大学

  • 歯科衛生学実習III

    2021
    Institution name:新潟大学

  • 全身管理学

    2020
    Institution name:新潟大学

  • 臨床実習Ⅰ

    2020
    Institution name:新潟大学

  • 臨床実習Ⅲ

    2020
    Institution name:新潟大学

  • 臨床実習Ⅱ

    2019
    Institution name:新潟大学

  • 歯科麻酔学

    2018
    Institution name:新潟大学

  • 歯科診療補助Ⅱ

    2011
    Institution name:新潟大学

  • 早期臨床実習Ⅰ

    2011
    Institution name:新潟大学

  • 早期臨床実習ⅠB

    2011
    Institution name:新潟大学

  • 顎顔面診断・治療学

    2011
    Institution name:新潟大学

  • 臨床予備実習

    2011
    Institution name:新潟大学

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