Updated on 2025/08/29

写真a

 
TSUJIMURA Takanori
 
Organization
Academic Assembly Institute of Medicine and Dentistry SHIGAKU KEIRETU Associate Professor
Graduate School of Medical and Dental Sciences Oral Life Science Oral Biological Science Associate Professor
Title
Associate Professor
Contact information
メールアドレス
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Degree

  • 博士(歯学) ( 2009.3   日本大学 )

Research Areas

  • Life Science / Prosthodontics

  • Life Science / Rehabilitation science  / 摂食嚥下リハビリテーション,嚥下障害

Research History (researchmap)

  • The Johns Hopkins Asthma and Allergy Center

    2022.9 - 2023.3

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    Country:United States

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  • Niigata University   Graduate School of Medical and Dental Sciences Dysphagia Rehabilitation   Associate Professor

    2015.4

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  • The Johns Hopkins Asthma and Allergy Center   Visiting assistant professor

    2012.7 - 2013.6

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    Country:United States

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  • Niigata University   Graduate School of Medical and Dental Sciences Dysphagia Rehabilitation   Assistant Professor

    2009.7 - 2015.3

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  • Nihon University   School of Dentistry   Postdoctoral Researcher

    2009.4 - 2009.7

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Research History

  • Niigata University   Graduate School of Medical and Dental Sciences Oral Life Science Oral Biological Science   Associate Professor

    2015.4

  • Niigata University   Faculty of Dentistry School of Dentistry   Assistant Professor

    2009.7 - 2015.3

  • Niigata University   Graduate School of Medical and Dental Sciences Oral Life Science Oral Biological Science   Assistant Professor

    2009.7 - 2015.3

Education

  • Nihon University   School of Dentistry   Department of Dentistry

    1999.4 - 2005.3

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Professional Memberships

  • The Japanese Society of Dysphagia Rehabilitation

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  • Japanese Society of Stomatognathic Function

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  • JAPANESE SOCIETY OF GERODONTOLOGY

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  • The society of swallowing and dysphagia of Japan

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  • JAPANESE ASSOCIATION FOR ORAL BIOLOGY

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  • JAPAN ASSOCIATION OF ORAL REHABILITATION

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  • Society for Neuroscience

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Committee Memberships

  • 日本嚥下医学会   編集委員  

    2024.9   

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    Committee type:Academic society

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  • 日本顎口腔機能学会   評議員  

    2018.4   

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  • 日本摂食嚥下リハビリテーション学会   評議員  

    2016.9   

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Studying abroad experiences

  • Johns Hopkins University   Visiting Assistant Professro

    2012.10 - 2013.9

 

Papers

  • Chewing Well Modulates Pharyngeal Bolus Transit During Swallowing in Healthy Participants Reviewed

    Akira Okubo, Takanori Tsujimura, Rumi Ueha, Taku Suzuki, Yuhei Tsutsui, Yuta Nakajima, Nobuaki Saka, Anna Sasa, Eri Takei, Jin Magara, Makoto Inoue

    Dysphagia   2024.12

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00455-024-10689-z

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  • Atropine facilitates water-evoked swallows via central muscarinic receptors in anesthetized rats. Reviewed International journal

    Yuta Nakajima, Takanori Tsujimura, Yuhei Tsutsui, Titi Chotirungsan, Satomi Kawada, Nozomi Dewa, Jin Magara, Makoto Inoue

    American journal of physiology. Gastrointestinal and liver physiology   325 ( 2 )   G109-G121   2023.8

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    Anticholinergic medication causes impaired swallowing with hyposalivation. However, the underlying mechanisms by which these drugs modulate the swallowing reflex remain unclear. This study investigated the effects of the muscarinic acetylcholine receptor (mAChR) non-specific antagonist atropine on the initiation of swallowing. Experiments were performed on 124 urethane-anesthetized rats. A swallow was evoked by either topical laryngeal application of a small amount of distilled water (DW), saline, citric acid, or capsaicin; upper airway distention with a continuous airflow; electrical stimulation of the superior laryngeal nerve (SLN); or focal microinjection of NMDAinto the lateral region of the nucleus of the solitary tract (L-nTS). Swallows were identified by electromyographic bursts of the suprahyoid and thyrohyoid muscles. Either atropine, the peripheral mAChR antagonist methylatropine, or antagonists of mAChR subtypes M1-M5 were intravenously delivered. Atropine at a dose of 1 mg/kg increased the number of DW-evoked swallows compared with baseline and did not affect the number of swallows evoked by saline, citric acid, capsaicin, or upper airway distention. Methylatropine and M1-M5 antagonists did not significantly change the number of DW-evoked swallows. Bilateral SLN transection completely abolished DW-evoked swallows, and atropine decreased the swallowing threshold of SLN electrical stimulation. Finally, microinjection of NMDA receptor antagonist AP-5 into the L-nTS inhibited DW-evoked swallows, and atropine facilitated the initiation of swallowing evoked by NMDA microinjection into this region. These results suggest that atropine facilitates DW-evoked swallows via central mAChR actions.

    DOI: 10.1152/ajpgi.00039.2023

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  • Inhibition of Water-Evoked Swallowing During Noxious Mechanical Stimulation of Tongue in Anesthetized Rats. Reviewed International journal

    Takanori Tsujimura, Yuta Nakajima, Titi Chotirungsan, Satomi Kawada, Yuhei Tsutsui, Midori Yoshihara, Taku Suzuki, Kouta Nagoya, Jin Magara, Makoto Inoue

    Dysphagia   2022.9

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    Dysphagia is sometimes accompanied by pain. Because orofacial structures subserve mastication and swallowing, orofacial pain might impair both functions. Tongue biting can occur not only accidentally while eating but also in some pathological conditions. However, it remains unclear whether noxious mechanical stimulation of the tongue affects swallowing. To explore this question, we evaluated the effects of lingual pinch stimulation on the initiation of swallowing evoked by distilled water (DW) infusion with a flow rate of 5.0 µL/s for 20 s into the pharyngolaryngeal region in anesthetized rats. The swallowing reflex was identified by electromyographic (EMG) bursts in the suprahyoid muscles which include the anterior belly of the digastric muscle, mylohyoid and geniohyoid muscles, and laryngeal elevation by visual inspection. The number of DW-evoked swallows during pinch stimulation was significantly smaller than that in a control condition or during pressure stimulation. The onset latency of the first swallow during pinch stimulation was significantly longer than that in the control condition. DW-evoked swallowing was almost abolished following bilateral transection of the superior laryngeal nerve (SLN) compared with the control condition, suggesting that the SLN plays a crucial role in the initiation of DW-evoked swallowing. Finally, electrophysiological data indicated that some SLN-responsive neurons in the nucleus tractus solitarii (nTS) exhibited delayed latency from a single SLN stimulation during lingual pinch stimulation. These results suggest that noxious mechanical stimulation of the tongue inhibits the initiation of swallowing and modulates neuronal activity in the nTS.

    DOI: 10.1007/s00455-022-10522-5

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  • Involvement of capsaicin-sensitive nerves in the initiation of swallowing evoked by carbonated water in anesthetized rats. Reviewed International journal

    Kojun Tsuji, Takanori Tsujimura, Shogo Sakai, Taku Suzuki, Midori Yoshihara, Kouta Nagoya, Jin Magara, Yoshihide Satoh, Makoto Inoue

    American journal of physiology. Gastrointestinal and liver physiology   319 ( 5 )   G564-G572   2020.9

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    Capsaicin powerfully evokes the swallowing reflex and is a known therapeutic agent for improving dysphagia and preventing aspiration pneumonia. However, the role of capsaicin-sensitive nerves in the initiation of swallowing evoked by various natural stimuli remains unclear. To explore this question, we blocked laryngeal capsaicin-sensitive nerves following the co-application of QX-314 and capsaicin (QX/Cap), and investigated the effects on swallowing evoked by mechanical and chemical stimulation in anesthetized rats. Swallows were evoked by capsaicin, carbonated water (CW), distilled water (DW), and punctate mechanical stimulation using von Frey filaments applied topically to the larynx. Swallows were documented by recording electromyographic activation of the suprahyoid and thyrohyoid muscles. The initiation of swallowing by capsaicin was strongly suppressed at 5 minutes following QX/Cap treatment and facilitated in a time-dependent manner. CW-evoked swallows at 5 min following QX/Cap treatment were significantly diminished compared with before and 30 min after treatment. In contrast, DW-evoked and mechanically evoked swallows were unchanged by QX/Cap treatment. Furthermore, CW-evoked swallows were virtually abolished by transection of the superior laryngeal nerves and significantly decreased by the topical application of ASIC3 inhibitor APET×2, but they were not affected by the non-selective TRP channel inhibitor ruthenium red or the ASIC1 inhibitor mambalgin-1. Taken together, we speculate that capsaicin-sensitive nerves play an important role in the initiation of CW-evoked swallows.

    DOI: 10.1152/ajpgi.00233.2020

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  • Involvement of the epithelial sodium channel in initiation of mechanically evoked swallows in anaesthetized rats Reviewed International journal

    Takanori Tsujimura, Rumi Ueha, Midori Yoshihara, Eri Takei, Kouta Nagoya, Naru Shiraishi, Jin Magara, Makoto Inoue

    The Journal of physiology   597 ( 11 )   2949 - 2963   2019.6

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    Authorship:Lead author, Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1113/JP277895

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  • Central inhibition of initiation of swallowing by systemic administration of diazepam and baclofen in anaesthetized rats Reviewed International coauthorship International journal

    Takanori Tsujimura, Shogo Sakai, Taku Suzuki, Izumi Ujihara, Kojun Tsuji, Jin Magara, Brendan J. Canning, Makoto Inoue

    American journal of physiology. Gastrointestinal and liver physiology   312 ( 5 )   G498 - G507   2017.5

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    DOI: 10.1152/ajpgi.00299.2016

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  • Differential response properties of peripherally and cortically evoked swallows by electrical stimulation in anesthetized rats Reviewed

    Takanori Tsujimura, Kojun Tsuji, Jin Magara, Shogo Sakai, Taku Suzuki, Yuki Nakamura, Kayoko Nozawa-Inoue, Makoto Inoue

    BRAIN RESEARCH BULLETIN   122   12 - 18   2016.4

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    DOI: 10.1016/j.brainresbull.2016.02.015

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  • Laryngeal and tracheal afferent nerve stimulation evokes swallowing in anaesthetized guinea pigs Reviewed International coauthorship International journal

    Takanori Tsujimura, Chioma Udemgba, Makoto Inoue, Brendan J. Canning

    The Journal of physiology   591 ( 18 )   4667 - 4679   2013.9

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    DOI: 10.1113/jphysiol.2013.256024

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  • Differential involvement of two cortical masticatory areas in modulation of the swallowing reflex in rats Reviewed International journal

    Takanori Tsujimura, Kojun Tsuji, Sajjiv Ariyasinghe, Takako Fukuhara, Aki Yamada, Hirokazu Hayashi, Yuki Nakamura, Koichi Iwata, Makoto Inoue

    Neuroscience letters   528 ( 2 )   159 - 164   2012.10

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    DOI: 10.1016/j.neulet.2012.09.005

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  • The Digastric Muscle is Less Involved in Pharyngeal Swallowing in Rabbits Reviewed

    Takanori Tsujimura, Aki Yamada, Yuki Nakamura, Takako Fukuhara, Kensuke Yamamura, Makoto Inoue

    DYSPHAGIA   27 ( 2 )   271 - 276   2012.6

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    DOI: 10.1007/s00455-011-9363-z

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  • Involvement of ERK phosphorylation in brainstem neurons in modulation of swallowing reflex in rats Reviewed International coauthorship International journal

    Takanori Tsujimura, Masahiro Kondo, Junichi Kitagawa, Yoshiyuki Tsuboi, Kimiko Saito, Haruka Tohara, Koichiro Ueda, Barry J. Sessle, Koichi Iwata

    The Journal of physiology   587 ( 4 )   805 - 817   2009.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1113/jphysiol.2008.165324

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  • Effect of Hyposalivation on Masticatory Movements While Eating Several Crackers in Healthy Individuals

    Kazuki Ikeura, Yuto Ochiai, Anna Sasa, Kazuhiro Ono, Ryo Takei, Hideaki Washio, Hajime Takahashi, Jin Magara, Takanori Tsujimura, Makoto Inoue

    Journal of Oral Rehabilitation   2025.8

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    DOI: 10.1111/joor.70048

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  • The Instruction of Chewing Well Affects Masticatory Activity and Bolus Flow During Rice Chewing in Healthy Humans

    Akira Okubo, Takanori Tsujimura, Rumi Ueha, Taku Suzuki, Eri Takei, Anna Sasa, Yuhei Tsutsui, Yuta Nakajima, Jin Magara, Makoto Inoue

    Journal of Oral Rehabilitation   2025.5

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    DOI: 10.1111/joor.14034

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  • Effect of Hyposalivation on Bread Mastication in Healthy Individuals

    Yuto Ochiai, Reiko Ita, Kazhihiro Ono, Takanori Tsujimura, Jin Magara, Makoto Inoue

    Journal of Oral Rehabilitation   2025.5

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    DOI: 10.1111/joor.13987

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  • The central neural control of the posterior belly of the digastric muscles during swallowing in rats

    Yuhei Tsutsui, Titi Chotirungsan, Charng-Rong Pan, Satomi Kawada, Jin Magara, Takanori Tsujimura, Keiichiro Okamoto, Makoto Inoue

    American Journal of Physiology-Gastrointestinal and Liver Physiology   2025.3

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    DOI: 10.1152/ajpgi.00374.2024

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  • Enhancing swallowing initiation: The facilitatory role of crystalline oil and fat

    Chisato Aizawa, Eri Takei, Jin Magara, Yasunobu Saito, Koki Noda, Yukiko Orihara, Mengjie Zhang, Takanori Tsujimura, Makoto Inoue

    Journal of Functional Foods   121   2024.10

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    DOI: 10.1016/j.jff.2024.106423

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  • Physiological analyses of swallowing changes due to chronic obstructive pulmonary disease in anesthetized male rats

    Kouta Nagoya, Takanori Tsujimura, Midori Yoshihara, Masahiro Watanabe, Jin Magara, Katsushige Kawasaki, Makoto Inoue

    Frontiers in Physiology   15   2024.8

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    Chronic obstructive pulmonary disease (COPD) was previously known as chronic bronchitis and emphysema. It has various main symptoms, such as dyspnea, chronic cough, and sputum, and is often accompanied by dysphagia. Although many published clinical reports have described COPD-related dysphagia, the physiological mechanisms underlying swallowing changes due to COPD remain unclear. Therefore, we analyzed how COPD affects the swallowing reflex using COPD model rats. We performed an electrophysiological study of respiration and swallowing using COPD model induced by intratracheal administration of porcine pancreatic elastase and lipopolysaccharide in Sprague-Dawley male rats. To identify the respiration and swallowing responses, electromyographic activity was recorded from the diaphragm, digastric (Dig), and thyrohyoid (TH) muscles. We confirmed COPD using micro-computed tomography analysis and hematoxylin and eosin staining of the lungs. The duty cycle was defined as the ratio of the inspiration duration to the total respiratory duration. In COPD model rats, the duty cycle was significantly higher than that in control rats. The frequency of the swallowing reflex evoked by electrical stimulation of the superior laryngeal nerve during the inspiration phase was higher in COPD model rats than in control rats. Furthermore, long-term COPD altered Dig and TH muscle activity without pathological muscle change. Our results suggest that COPD increases the frequency of swallowing initiation during the inspiration phase. Furthermore, long-term COPD affects swallowing-related muscle activity without pathological muscle changes. These physiological changes may increase the risk of developing dysphagia. Further studies are necessary to clarify the mechanisms contributing to the functional changes in respiration and swallowing in COPD.

    DOI: 10.3389/fphys.2024.1445336

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  • Functional involvement of the sternohyoid muscle during breathing and swallowing in rats. International journal

    Nobuaki Saka, Titi Chotirungsan, Midori Yoshihara, Charng-Rong Pan, Yuhei Tsutsui, Nozomi Dewa, Jin Magara, Takanori Tsujimura, Makoto Inoue

    American journal of physiology. Gastrointestinal and liver physiology   2024.8

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    The sternohyoid muscle depresses the hyoid bone, but it is unclear whether the muscle contributes to respiratory and swallowing mechanisms. This study aimed to clarify whether the sternohyoid muscle participates in the respiration and swallowing reflex and how the activity is modulated in two conditions: with airway stenosis and with a fixed sternohyoid muscle length. Electromyographic activity in the sternohyoid, digastric, thyrohyoid, and diaphragm muscles was recorded in anesthetized rats. The sternohyoid muscle activity was observed in the inspiratory phase and during swallowing, and was well coordinated with digastric and thyrohyoid muscle activity. With airway stenosis, the respiratory activity per respiratory cycle was facilitated in all assessed muscles but the facilitation of activity per second occurred only in the digastric, thyrohyoid, and sternohyoid muscles. With airway stenosis, the swallowing activity was facilitated only in the digastric muscle but not in the thyrohyoid and sternohyoid muscles. Swallowing activity was not observed in the sternohyoid muscle in the condition with the sternohyoid muscle length fixed, although increased inspiratory activity remained. The current results suggest that (1) the sternohyoid muscle is slightly activated in the inspiratory phase, (2) the effect of airway stenosis on respiratory function may differ between the upper airway muscles and diaphragm, and (3) swallowing activity in the sternohyoid muscle is not dominantly controlled by the swallowing central pattern generator but instead occurs as a myotatic reflex.

    DOI: 10.1152/ajpgi.00138.2024

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  • Effect of bolus property on swallowing dynamics in patients with dysphagia

    Haruka Hino, Taku Suzuki, Kazuya Maekawa, Reiko Ita, Anna Sasa, Sirima Kulvanich, Eri Takei, Jin Magara, Takanori Tsujimura, Makoto Inoue

    Journal of Oral Rehabilitation   2024.8

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    DOI: 10.1111/joor.13709

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  • Effect of carbonation and thickening on voluntary swallow in healthy humans. International journal

    Hajime Iwamori, Jin Magara, Wakana Onuki, Reiko Ita, Anna Sasa, Takanori Tsujimura, Makoto Inoue

    Journal of oral rehabilitation   2024.7

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    BACKGROUND: Liquid modification is a widely established strategy of treatment for patients with dysphagia. The modification of liquid particularly by thickening or carbonation is a common approach to promote safe swallowing. OBJECTIVE: This study sought to investigate how carbonated and/or thickened water modulates swallowing behaviours during swallowing in healthy young individuals. METHODS: Thirty-one healthy volunteers (9 men, 22 women; mean age ± standard deviation [SD], 25.7 ± 6.2 years) were instructed to swallow 20 mL of water, carbonated water and carbonated juice with and without added thickening agent. Electromyograms (EMGs) of the suprahyoid (S-hyo) muscles were recorded to evaluate swallowing behaviours. Obtained S-hyo EMG bursts was analysed using the following outcome parameters: onset latency, the time between swallowing que to onset of EMG burst; rising time and falling time, defined as the time between onset and peak, and between peak and offset, respectively; duration, defined as the time between onset and offset of EMG burst; and area integral value under the waveform. RESULTS: Effects of thickening demonstrated the extended onset latency, EMG burst duration including falling time and the larger area of EMG in thickened liquid compared to thin liquid, but there was not much difference between thin and thickened carbonated liquids. Carbonation significantly decreased the duration including falling time for thickened but not for thin liquids. CONCLUSION: Patients with dysphagia can benefit from use of carbonated or thickened water while the effects on swallowing physiology may differ between carbonation and thickening.

    DOI: 10.1111/joor.13793

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  • Impact of salivary flow inhibition on masticatory behaviours in healthy individuals. International journal

    Rie Goto, Yuto Ochiai, Eri Takei, Reiko Ita, Kazhihiro Ono, Ryo Takei, Hideaki Washio, Hajime Takahashi, Takanori Tsujimura, Jin Magara, Makoto Inoue

    Journal of oral rehabilitation   2024.6

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    BACKGROUND: It remains unclear how the salivary flow and the fat content of food affect bolus formation during mastication. OBJECTIVES: We aimed to clarify: (1) how hyposalivation affects jaw-closing and hyoid-elevating muscle activities in bolus formation, and (2) if the effect of hyposalivation on muscle activity depends on the fat content of food. METHODS: Eighteen healthy male volunteers were instructed to freely ingest four test foods: Plain, Fat without seasoning, Fat with seasoning, and Soft rice crackers. Masseter and suprahyoid electromyographic activities were recorded before and 30 min after the administration of atropine sulfate, a muscarinic receptor antagonist that induces hyposalivation. RESULTS: Hyposalivation extended the masticatory duration significantly in all the test foods except Fat with seasoning. Masticatory cycle time was significantly longer with vs without hyposalivation for the Soft (p = .011). Suprahyoid activity/cycle was significantly greater with vs without hyposalivation (p = .013). Masticatory cycle time was significantly longer at the late stage with vs without hyposalivation for the Soft (p < .001). Suprahyoid activity/cycle was significantly greater at the middle (p = .045) and late stages (p = .002) with vs without hyposalivation for the Soft and greater at the late stage with vs without hyposalivation for the Plain (p = .043). Changes in masticatory cycle time and suprahyoid activity/cycle for these foods had significantly positive relationship (p < .001). CONCLUSION: Hyposalivation-induced changes in masticatory behaviours resulted from the middle and late stage suprahyoid activity. Fat content and seasoning compensate for salivary flow inhibition.

    DOI: 10.1111/joor.13764

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  • Continuous electrical stimulation of superior laryngeal nerve inhibits initiation of swallowing in anesthetized rats. Reviewed International journal

    Yuta Nakajima, Takanori Tsujimura, Kojun Tsuji, Jin Magara, Makoto Inoue

    Neuroscience letters   825   137672 - 137672   2024.3

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    Pharyngeal electrical stimulation (PES) applies electrical stimulation to pharyngeal mucosa (PhM) and represents a useful approach to improve swallowing function in patients with dysphagia. To determine the optimal PES modality to treat dysphagia, the mechanism underlying the effects of PES on swallowing function must be elucidated. In this study, we evaluated how PES and electrical stimulation of the superior laryngeal nerve (SLN) modulate the initiation of swallowing in anesthetized rats. A swallow was evoked by electrical stimulation of the PhM, SLN, and nucleus of the solitary tract (nTS) and pharyngeal mechanical stimulation using a von Frey filament. A swallow was identified by electromyographic bursts in mylohyoid and thyrohyoid muscles. Bilateral SLN transection abolished the swallows evoked by PhM electrical stimulation. PhM and SLN electrical stimulation decreased swallowing frequency in a similar time-dependent manner. Intravenous administration of the GABAA receptor antagonist bicuculine did not affect the time-dependent change in swallowing frequency during SLN electrical stimulation. Continuous SLN electrical stimulation significantly inhibited pharyngeal mechanically and nTS-electrically evoked swallows compared with before and 5 min after stimulation. The present findings suggest that the SLN plays a primary role in PES-evoked swallows. Additionally, continuous SLN electrical stimulation inhibits the initiation of swallowing, and the modulation of central network associated with swallowing might be partially involved in this inhibition.

    DOI: 10.1016/j.neulet.2024.137672

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  • Short-term and long-term effects of unilateral external carotid artery ligation on orofacial functions in rats. Reviewed International journal

    Titi Chotirungsan, Yuhei Tsutsui, Nobuaki Saka, Satomi Kawada, Nozomi Dewa, Jin Magara, Takanori Tsujimura, Makoto Inoue

    American journal of physiology. Gastrointestinal and liver physiology   326 ( 3 )   G318-G329   2024.3

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    The external carotid artery (ECA) plays a major role in supplying blood to the head and neck. Although impeded blood flow in the ECA is expected to affect orofacial functions, few studies have shown how blood flow obstruction in the ECA contributes to impairment of these functions, including chewing and swallowing. This study was performed to investigate the effects of ECA ligation (ECAL) on immediate and long-term changes in masticatory and swallowing functions as well as the jaw-opening reflex evoked in the digastric muscle. The experiments were carried out using male Sprague-Dawley rats. In the acute experiment, the digastric reflex evoked by low-threshold electrical stimulation of the inferior alveolar nerve and the swallow reflex, identified by digastric and thyrohyoid electromyographic (EMG) bursts, were compared between before and 1 h after ECAL. The chronic experiment was conducted on freely moving rats. EMGs of the masseter, digastric, and thyrohyoid muscles were chronically recorded. The long-term effects of ECAL on behavior and muscle histology were compared between rats with an intact ECA and rats with ECAL. In the acute experiment, the peak amplitude of the digastric reflex on the ECAL side was significantly decreased 1 h after ECAL. In the chronic experiment, although most parameters of the masticatory and swallowing EMGs were not significantly different between the groups, the results suggest wide variation of the effect of ECAL on the muscles. Blood supply compensation from collaterals of the internal carotid artery may be permanent in some animals.NEW & NOTEWORTHY The inhibitory effect of unilateral external carotid artery ligation (ECAL) on the ipsilateral digastric reflex was small but evident. Most parameters of masticatory and swallowing muscle activity were not significantly different after ECAL. Wide variation was noted in the effect of ECAL on the ipsilateral muscle activity. Blood supply compensation from collaterals of the internal carotid artery may occur in response to the impaired blood flow.

    DOI: 10.1152/ajpgi.00226.2023

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  • COVID-19感染症下での介護保険施設における歯科訪問診療の中断が肺炎の発症に与える影響について(Effect of COVID-19-related interruption of visiting dental services on pneumonia in nursing home residents) Reviewed

    伊藤 加代子, 落合 勇人, 阿志賀 大和, 林 宏和, 飯泉 智子, 鈴木 拓, 道見 登, 花形 哲夫, Kulvanich Sirima, 那小屋 公太, 渡邊 賢礼, 真柄 仁, 辻村 恭憲, 井上 誠

    新潟歯学会雑誌   53 ( 2 )   73 - 80   2024.1

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  • Effects of Head and Neck Alignment and Pharyngeal Anatomy on Epiglottic Inversion During Swallowing in Dysphagic Patients. Reviewed International journal

    Taku Suzuki, Haruka Hino, Jin Magara, Takanori Tsujimura, Kayoko Ito, Makoto Inoue

    Dysphagia   38 ( 6 )   1519 - 1527   2023.12

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    The effects of head and neck alignment and pharyngeal anatomy on epiglottic inversion remain unclear. This study investigated the factors involved in epiglottic inversion, including head and neck alignment and pharyngeal anatomy, in patients with dysphagia. Patients with a chief complaint of dysphagia and who underwent videofluoroscopic swallowing study at our hospital from January to July 2022 were enrolled. They were divided into three groups based on the degree of epiglottic inversion as the complete-inversion (CI), partial-inversion (PI), and non-inversion group (NI) groups. Data were compared among the three groups; a total of 113 patients were analyzed. The median age was 72.0 (IQR: 62.0-76.0) years; 41 (36.3%) and 72 (63.7%) were women and men, respectively. There were in 45 (39.8%) patients in the CI, 39 (34.5%) in the PI, and 29 (25.7%) in the NI groups, respectively. Single-variable analysis revealed significant relation to epiglottic inversion of Food Intake LEVEL Scale score, penetration-aspiration score with 3-mL thin liquid bolus, epiglottic vallecula and pyriform sinus residue, hyoid position and displacement during swallowing, pharyngeal inlet angle (PIA), epiglottis to posterior pharyngeal wall distance, and body mass index. Logistic regression analysis with complete epiglottic inversion as the dependent variable revealed the X coordinate at maximum hyoid elevation position during swallowing and PIA as significant explanatory variables. These results suggest that epiglottic inversion is constrained in patients with dysphagia who have poor head and neck alignment or posture and a narrow pharyngeal cavity just before swallowing.

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  • Modulation of reflex responses of the anterior and posterior bellies of the digastric muscle in freely moving rats. Reviewed International journal

    Titi Chotirungsan, Yuhei Tsutsui, Nobuaki Saka, Satomi Kawada, Nozomi Dewa, Taku Suzuki, Jin Magara, Takanori Tsujimura, Makoto Inoue

    Journal of oral rehabilitation   50 ( 11 )   1270 - 1278   2023.11

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    BACKGROUND: Chewing and licking are primarily activated by central pattern generator (CPG) neuronal circuits in the brainstem and when activated trigger repetitive rhythmic orofacial movements such as chewing, licking and swallowing. These CPGs are reported to modulate orofacial reflex responses in functions such as chewing. OBJECTIVE: This study explored the modulation of reflex responses in the anterior and posterior bellies (ant-Dig and post-Dig, respectively) of the digastric muscle evoked by low-intensity trigeminal stimulation in conscious rats. METHODS: The ant-Dig and post-Dig reflexes were evoked by using low-intensity electrical stimulation applied to either the right or left inferior alveolar nerve. Peak-to-peak amplitudes and onset latencies were measured. RESULTS: No difference was observed between threshold and onset latency for evoking ant-Dig and post-Dig reflexes, suggesting that the latter was also evoked disynaptically. The peak-to-peak amplitude of both reflexes was significantly reduced during chewing, licking and swallowing as compared to resting period and was lowest during the jaw-closing phase of chewing and licking. Onset latency was significantly largest during the jaw-closing phase. Inhibitory level was similar between the ant-Dig and post-Dig reflex responses and between the ipsilateral and contralateral sides. CONCLUSION: These results suggest that both the ant-Dig and post-Dig reflex responses were significantly inhibited, probably due to CPG activation during feeding behaviours to maintain coordination of jaw and hyoid movements and hence ensure smooth feeding mechanics.

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  • Use of suction electrodes for measurement of intrinsic tongue muscular endurance during lingual pressure generation. Reviewed International journal

    Reiko Ita, Jin Magara, Yuto Ochiai, Takanori Tsujimura, Makoto Inoue

    Journal of oral rehabilitation   2023.10

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    BACKGROUND: Lingual pressure (LP) generation is cooperatively controlled not only by the intrinsic tongue (I-ton) muscles but also by hyoid muscle activation. However, the measurement of endurance and fatigue properties of I-ton muscles is difficult due to the instability of electrodes. OBJECTIVE: The purpose of this study was to apply suction electrodes to measure electromyograms (EMGs) of I-ton muscle and to evaluate integrated EMG amplitude (iEMG) and mean power frequency (MPF) of EMG in the I-ton and hyoid muscles performing continuous LP. METHODS: Twenty healthy adult volunteers (10 males, 10 females, mean age 28.8 years) were instructed to perform 10-s LP generation tasks at 25%, 50%, 75% and 100% of maximum LP in randomised order with visual feedback. During each task, EMGs of the I-ton, suprahyoid (S-hyo), infrahyoid (I-hyo) and masseter (Mass) muscles were simultaneously recorded. The iEMG and MPF of EMG burst during 10-s LP tasks were compared. The recording period was divided into three substages to analyse temporal changes with the Friedman test. RESULTS: During the 10-s task, the iEMG significantly increased as the LP strength increased (p < .001). There was no time-dependent change in the I-ton iEMG; however, the MPF of the I-ton EMG burst decreased in all tasks (p < .05). The S-hyo and I-hyo iEMGs gradually increased, especially with strong LP (p < .01). CONCLUSION: While I-ton muscles may easily fatigue during 10-s LP generation, S-hyo and I-hyo muscles may help compensate for the weakened I-ton muscle activity by increasing their activity to maintain LP.

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  • Evaluating the effect of management on patients with oral hypofunction: A longitudinal study. Reviewed International journal

    Wakana Onuki, Jin Magara, Kayoko Ito, Reiko Ita, Satomi Kawada, Yuhei Tsutsui, Yuta Nakajima, Haruka Sakai, Takanori Tsujimura, Makoto Inoue

    Gerodontology   40 ( 3 )   308 - 316   2023.9

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    INTRODUCTION: Declining oral function may affect subsequent physical frailty in the older population. The aim of this longitudinal study was to summarise data on patients who underwent functional oral examination and evaluate the impact of management on patients with oral hypofunction (OHF). METHODS: Dental outpatients aged over 65 years at their initial visit to the Niigata University Hospital received detailed assessment of seven oral function items to diagnose oral hypofunction using diagnostic criteria defined by the Japanese Society of Gerodontology. Patients with OHF at the first assessment received management including oral health guidance for low function and dental treatment. They were re-evaluated approximately 6 months later and the two assessments were compared. According to the results of the second assessment, the patients were divided into two groups: OHF improved and OHF re-diagnosed. RESULTS: Of the 273 patients who underwent the first assessment, 86 (31.5%) were diagnosed with OHF and received management. Of those, 42 (48.8%) completed the second assessment. Comparing the first and second assessment, significant improvement was observed in oral hygiene, occlusal force, tongue-lip motor function of /pa/, mastication and swallowing. The change in values from the first assessment demonstrated a significant difference between the OHF improved and re-diagnosed groups only in occlusal force. CONCLUSION: Management for patients with OHF can contribute to the improvement of poor oral function, and an increase in occlusal force was notable in the recovery from OHF.

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  • 小脳橋角部腫瘍摘出術後の咀嚼障害に対して筋電位バイオフィードバックを用いてリハビリテーション介入を行った一例 Reviewed

    川田 里美, 鈴木 拓, 大久保 明, 辻村 恭憲, 井上 誠

    新潟歯学会雑誌   52 ( 2 )   77 - 82   2022.12

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  • Cause of Impairments of Bolus Transport and Epiglottis Inversion. Reviewed International journal

    Taku Suzuki, Sirima Kulvanich, Takanori Tsujimura, Jin Magara, Yasushi Ohnishi, Makoto Inoue

    Dysphagia   37 ( 6 )   1858 - 1860   2022.12

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  • Functional evaluation of jaw and suprahyoid muscle activities during chewing Reviewed

    Anna Sasa, Sirima Kulvanich, Naohito Hao, Reiko Ita, Masahiro Watanabe, Taku Suzuki, Jin Magara, Takanori Tsujimura, Makoto Inoue

    Journal of Oral Rehabilitation   2022.9

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    DOI: 10.1111/joor.13373

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  • Chewing modulates the human cortical swallowing motor pathways. Reviewed International journal

    Jin Magara, Wakana Onuki, Reiko Ita, Takanori Tsujimura, Makoto Inoue

    Physiology & behavior   249   113763 - 113763   2022.5

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    When eating, mastication is always followed by swallowing. The present study assessed the effect of mastication on swallowing-related neural pathways in humans. Twenty healthy volunteers participated and underwent baseline transcranial magnetic stimulation to evaluate cortico-pharyngeal and cortico-hand motor-evoked potentials (MEPs). Next, they performed a chewing task and a swallowing task. Repeated-measures ANOVA revealed that pharyngeal MEPs were significantly higher after the swallowing task than after the chewing task, even though the number of swallows across tasks was matched. This implies that chewing movements suppress swallowing-related activity in the pharyngeal motor circuit.

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  • Impact of oral function on regaining oral intake and adjusting diet forms for acute stroke patients. Reviewed International journal

    Sirima Kulvanich, Haruka Sakai, Riho Takanami, Mako Yamada, Anna Sasa, Kayoko Ito, Takanori Tsujimura, Jin Magara, Makoto Inoue

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   31 ( 5 )   106401 - 106401   2022.5

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    BACKGROUND: Outcome prediction for dysphagia recovery is essential for rehabilitation treatment planning. Several studies have reported various predictors for resuming oral feeding after post-stroke dysphagia. However, evidence on oral health and function, a crucial part of feeding, has rarely been reported. Therefore, the goal of this study was to identify the oral status-related factors that could predict oral intake resumption in acute stroke patients. METHODS: 80 acute stroke patients with dysphagia were included. Clinical data, including the changes of general condition, oral and swallowing functions, were collected once a week until discharge. Patients were divided into two groups based on the outcome of the food intake level scale at discharge, and data were compared between the groups. RESULTS: 60 patients had regained complete oral intake before discharge. Multiple logistic regression showed that posterior tongue pressure could significantly predict complete oral intake recovery. Tongue pressure and modified water swallowing test score also significantly influenced diet forms. In addition, Spearman correlation analysis showed that improvement of other oral status-related factors, such as oral moisture and dentition status, also indicated the improvement of diet forms and swallowing function during the hospital stay. CONCLUSION: Tongue pressure measurement could be a useful oral status-related indicator for predicting complete oral intake and adjusting diet forms for acute stroke patients during hospitalization. Acute stroke patients should receive proper oral status evaluation and implementation to enhance functional recovery.

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  • Functional Role of Suprahyoid Muscles in Bolus Formation During Mastication. Reviewed International journal

    Anna Sasa, Sirima Kulvanich, Naohito Hao, Reiko Ita, Masahiro Watanabe, Taku Suzuki, Jin Magara, Takanori Tsujimura, Makoto Inoue

    Frontiers in physiology   13   881891 - 881891   2022

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    It still remains unclear how the suprahyoid muscles function in bolus formation during mastication. This study aimed to investigate the contributory role of the suprahyoid muscles during mastication. A total of 20 healthy young volunteers were asked to perform tongue pressure generation tasks and unilateral mastication tasks using peanuts and two different types of rice crackers. Surface electromyographic (EMG) activity of the masseter and suprahyoid muscles and mandibular kinematics were recorded. Suprahyoid activity increased with increasing tongue pressure. Masticatory duration until the first deglutition differed significantly among the different foods; the harder the food, the longer the duration. This was also the case in masseter activity per masticatory cycle. Masticatory rate and suprahyoid activity per masticatory cycle were significantly higher during soft rice cracker mastication. Masseter activity was higher on the masticatory side than on the non-masticatory side, however, there was no difference in suprahyoid activity between the sides. Suprahyoid activity and jaw gape showed significant positive correlation in the early stage on both the masticatory and non-masticatory sides. The suprahyoid muscles functioned dominantly for jaw-opening during peanut mastication, and for bolus formation, especially in the late stage during soft rice cracker mastication. Bolus formation was performed dominantly on the masticatory side during rice cracker mastication. These findings clearly demonstrate a functional role of the suprahyoid muscles during mastication of solid foods from assessments using both EMG activity and mandibular kinematic recordings.

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  • Antitussive effects of NaV 1.7 blockade in Guinea pigs. Reviewed International journal

    Li Yu, Kojun Tsuji, Izumi Ujihara, Qi Liu, Nikoleta Pavelkova, Takanori Tsujimura, Makoto Inoue, Sonya Meeker, Eric Nisenbaum, Jeff S McDermott, Jeff Krajewski, Bradley J Undem, Marian Kollarik, Brendan J Canning

    European journal of pharmacology   907   174192 - 174192   2021.9

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    Our previous studies implicated the voltage-gated sodium channel subtype NaV 1.7 in the transmission of action potentials by the vagal afferent nerves regulating cough and thus identified this channel as a rational therapeutic target for antitussive therapy. But it is presently unclear whether a systemically administered small molecule inhibitor of NaV 1.7 conductance can achieve therapeutic benefit in the absence of side effects on cardiovascular function, gastrointestinal motility or respiration. To this end, we have evaluated the antitussive effects of the NaV 1.7 selective blocker Compound 801 administered systemically in awake guinea pigs or administered topically in anesthetized guinea pigs. We also evaluated the antitussive effects of ambroxol, a low affinity NaV blocker modestly selective for tetrodotoxin resistant NaV subtypes. Both Compound 801 and ambroxol dose-dependently inhibited action potential conduction in guinea pig vagus nerves (assessed by compound potential), with ambroxol nearly 100-fold less potent than the NaV 1.7 selective Compound 801 in this and other NaV 1.7-dependent guinea pig and human tissue-based assays. Both drugs also inhibited citric acid evoked coughing in awake or anesthetized guinea pigs, with potencies supportive of an NaV 1.7-dependent mechanism. Notably, however, the antitussive effects of systemically administered Compound 801 were accompanied by hypotension and respiratory depression. Given the antitussive effects of topically administered Compound 801, we speculate that the likely insurmountable side effects on blood pressure and respiratory drive associated with systemic dosing make topical formulations a viable and perhaps unavoidable therapeutic strategy for targeting NaV 1.7 in cough.

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  • Survey of oral hypofunction in older outpatients at a dental hospital. Reviewed International journal

    Wakana Onuki, Jin Magara, Takanori Tsujimura, Kayoko Ito, Haruka Sakai, Sirima Kulvanich, Yuta Nakajima, Nobuaki Saka, Makoto Inoue

    Journal of oral rehabilitation   48 ( 10 )   1173 - 1182   2021.8

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    BACKGROUND: Oral hypofunction is defined as the reversible stage preceding oral dysfunction. However, its assessment and management need further examination and consideration. OBJECTIVE: The present study aimed to examine the current state of oral hypofunction among outpatients at the university hospital. METHODS: New outpatients underwent medical interviews and detailed assessment of oral hypofunction at their initial visit to our dental department. Oral hypofunction was diagnosed if the results of three of the following seven assessment items were below cut-off values: poor oral hygiene, oral dryness, reduced occlusal force, decreased tongue-lip motor function, decreased tongue pressure, decreased masticatory function and deterioration of swallowing function. The relationships between factors used to diagnose oral hypofunction as well as the distributions of assessment values were clarified. RESULTS: Seventy-five of 209 patients (35.9%) were finally diagnosed with oral hypofunction. Diagnosis of oral hypofunction was significantly related to patient age, Eichner index, a chief complaint of dental or periodontal disease or ill-fitting dentures and a history of neurodegenerative disease. The lowest quintile values for poor oral hygiene, oral dryness and decreased masticatory performance were all above current cut-off values. Reduced occlusal force contributed strongly to the diagnosis of oral hypofunction. CONCLUSION: Oral hypofunction in dental outpatients at a university hospital was associated with patient age, medical history and chief complaint at presentation. Diagnosis of oral hypofunction can be closely related to reduced occlusal force. The validity of cut-off values for assessments of oral hypofunction needs further consideration.

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  • 誤嚥性肺炎入院患者に対する摂食嚥下機能評価フローの立案と有効性の検討 Reviewed

    建部 一毅, 石田 雅樹, 真柄 仁, 小幡 裕明, 樋浦 徹, 前川 和也, 伊藤 加代子, 辻村 恭憲, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌   25 ( 2 )   90 - 101   2021.8

  • 原疾患の管理が安定後も合併症の問題により、嚥下障害の対応に難渋した皮膚筋炎の一例 Reviewed

    落合 勇人, 辻村 恭憲, 渡邊 賢礼, 那小屋 公太, 高波 里帆, 山田 真子, 井上 誠

    新潟歯学会雑誌   51 ( 1 )   45 - 50   2021.8

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  • Rapid Onset of Weight Gain and Liver Dysfunction Successfully Treated With Nutrition and Exercise. Reviewed International journal

    Hiroteru Kamimura, Masakazu Sano, Takanori Tsujimura, Yasunaga Takeda, Yuko Komoro, Junji Yokoyama, Shuji Terai

    Cureus   13 ( 7 )   e16530   2021.7

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    Physical inactivity is one of the causes of most metabolic syndromes. The incidence of metabolic syndrome is expected to increase in the near future because of the reduced opportunities for exercise caused by COVID-19. Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease. Changes in diet and lifestyle have led to a dramatic increase in the prevalence of NAFLD in the world. NAFLD is characterized by excessive triglyceride (TG) accumulation in the hepatocytes due to both increased inflow of free fatty acids and de novo hepatic lipogenesis. Thus far, no study quantitatively assessed the liver fat deposition after a rapid decline in physical activity. Herein, we describe a case of a 17-year-old Japanese boy with severe fat infiltration of the liver, due to a rapid decline in physical activity, treated at our facility. Our rehabilitation and nutritional support teams administered appropriate exercise and nutrition support to reduce weight and improve liver dysfunction. Our findings support dietary changes and exercise therapy to manage such cases.

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  • Effects of Carbonation and Temperature on Voluntary Swallowing in Healthy Humans. Reviewed International journal

    Chikako Takeuchi, Eri Takei, Kayoko Ito, Sirima Kulvanich, Jin Magara, Takanori Tsujimura, Makoto Inoue

    Dysphagia   36 ( 3 )   384 - 392   2021.6

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    We investigated how swallowing behaviors are affected by the temperature and carbonation of water in healthy humans. Twenty-nine healthy volunteers were instructed to drink as much natural water, carbonated water, or cider as they wanted, and we recorded the volume of solution swallowed and electromyographic (EMG) activity of the masseter and suprahyoid muscles. Sensory tests regarding the ease of holding the solution in the mouth and ease of swallowing were also performed. The volume of carbonated water swallowed was significantly lower than that of natural water and cider. The ease of holding and swallowing the solution significantly differed between solution types such that natural water was the easiest solution to hold and swallow, followed by cider and then carbonated water in both tests. EMG activity was also affected by the solution type. Masseter EMG activity was significantly lower when swallowing natural water compared with carbonated water. Suprahyoid EMG activity was significantly lower when swallowing natural water compared with carbonated water and cider. The volume of solution swallowed was significantly correlated with the ease of holding and swallowing the solution, but not with masseter or suprahyoid EMG activities. The ease of holding and swallowing the solution significantly affected masseter and suprahyoid EMG activities. The results suggested that when participants experienced difficulty holding and swallowing the solution, masseter and suprahyoid EMG activity increased. Considering our findings that mechanical stimulation with bubbles decreased the volume of solution swallowed and increased EMG activities, carbonated water swallowing may be useful in treating deglutition disorders.

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  • Changes of bolus properties and the triggering of swallowing in healthy humans. Reviewed International journal

    Izumi Kochi, Eri Takei, Rumiko Maeda, Kayoko Ito, Jin Magara, Takanori Tsujimura, Sirima Kulvanich, Makoto Inoue

    Journal of oral rehabilitation   48 ( 5 )   592 - 600   2021.5

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    There is wide variation in chewing behaviours, even among healthy humans. Further, the way in which humans determine swallowing initiation when chewing solid foods remains unclear. The current study sought to investigate how the bolus properties change over time during chewing, and to clarify which factors affect chewing and swallowing behaviours, including swallowing initiation, in healthy humans. Twenty-four healthy volunteers were instructed to chew 8 g of steamed rice and spit it out at 50%, 100% and 150% of their own chewing duration, defined as the time of chewing from onset of the first chewing cycle to onset of the first swallow. Chewing and swallowing behaviours were monitored and determined by visual inspection of video recordings. The physical properties such as hardness, cohesiveness and adhesiveness as well as water content of the bolus were measured. In each subject, maximum bite force, tongue pressure and stimulated salivary flow rate were also measured. Hardness gradually decreased, and the cohesiveness and water content of the bolus did not change up to 50% of chewing duration, followed by a slight but significant increase. The adhesiveness of the bolus rapidly decreased at the beginning of chewing. Chewing duration was significantly related to stimulated salivary flow rate; greater salivary flow rate was associated with shorter chewing duration. Variation of chewing duration and swallowing initiation was not dependent on bolus properties during the chewing of steamed rice, but mainly depended on the surface lubrication of the bolus.

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  • Relationships Between Survival and Oral Status, Swallowing Function, and Oral Intake Level in Older Patients with Aspiration Pneumonia. Reviewed International journal

    Taku Suzuki, Takanori Tsujimura, Jin Magara, Naohito Hao, Naru Shiraishi, Kazuya Maekawa, Kazuo Matsushima, Makoto Inoue

    Dysphagia   37 ( 3 )   558 - 566   2021.4

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    The factors affecting the survival of patients with aspiration pneumonia (AP) remain unclear. This study aimed to determine whether factors, including oral status, swallowing function, and oral intake level, were related to survival outcomes in older patients hospitalized for AP. The study enrolled patients with AP who were admitted to our hospital between February 2017 and November 2019. Patients were divided into two groups based on the 90-day mortality after the first swallowing function evaluation: survivors and deceased. The data were compared between the two groups. A total of 29 patients were diagnosed with AP. Of these patients, 13 died within 90 days. The numbers of patients who could not use removable dentures and required sputum suctioning and had cough reflex at rest were significantly higher in the deceased than in the survivors. The salivary pooling and pharyngeal clearance scores evaluated by videoendoscopy, International Dysphagia Diet Standardisation Initiative Functional Diet Scale score determined after swallowing function evaluation, and consciousness level were significantly worse in the deceased than in the survivors. There were significant differences in patients' oral status, swallowing function, oral intake level, and consciousness level between the survivors and deceased.

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  • Lasting modulation of human cortical swallowing motor pathways following thermal tongue stimulation. Reviewed International journal

    Jin Magara, Masahiro Watanabe, Takanori Tsujimura, Shaheen Hamdy, Makoto Inoue

    Neurogastroenterology and motility   33 ( 1 )   e13938   2021.1

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    BACKGROUND: Thermal tactile oropharyngeal stimulation has been clinically used to facilitate swallowing initiation in dysphagic patients. We previously demonstrated that thermal stimulation applied to the oral cavity provokes an immediate excitability in pharyngeal motor cortex. The aim of the current study was to investigate whether thermal stimulation can produce longer lasting effects on the corticopharyngeal neural pathway. METHODS: Healthy volunteers (n = 8/12) underwent baseline pharyngeal motor evoked potential (PMEP) measurements evoked by transcranial magnetic stimulation. In the first experiment, subjects received thermal stimulation alternating 30 seconds of 15 and 36°C applied to the tongue surface for either 10 minutes, 5 minutes, or sham. In the second experiment, one of three intermittent thermal stimulus patterns was delivered: cold (alternating 30 seconds of 15 and 36°C), warm (continuous 36°C), or hot (alternating 30 seconds of 45 and 36°C) for 10 minutes. In both experiments, PMEP were remeasured every 15 minutes up to 60 minutes following thermal stimulation. KEY RESULTS: Repeated measures ANOVA for each stimulus time in the first experiment showed a significant increased change in PMEP amplitude at 30 minutes following only 10-minute stimulation compared with sham (P < .05). In the second experiment, we found that cold stimulation was more effective than the other stimulation (P < .05) at increasing PMEP amplitudes. CONCLUSIONS AND INFERENCES: Ten-minute cold stimulation on the tongue can induce a delayed (30 minutes) increase in pharyngeal cortical excitability, providing a clinically useful therapeutic window for its application in dysphagic patients.

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  • Coordination of Respiration, Swallowing, and Chewing in Healthy Young Adults. Reviewed International journal

    Naohito Hao, Anna Sasa, Sirima Kulvanich, Yuta Nakajima, Kouta Nagoya, Jin Magara, Takanori Tsujimura, Makoto Inoue

    Frontiers in physiology   12   696071 - 696071   2021

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    Examining the coordination of respiration and swallowing is important for elucidating the mechanisms underlying these functions and assessing how respiration is linked to swallowing impairment in dysphagic patients. In this study, we assessed the coordination of respiration and swallowing to clarify how voluntary swallowing is coordinated with respiration and how mastication modulates the coordination of respiration and swallowing in healthy humans. Twenty-one healthy volunteers participated in three experiments. The participants were asked to swallow 3 ml of water with or without a cue, to drink 100 ml of water using a cup without breathing between swallows, and to eat a 4-g portion of corned beef. The major coordination pattern of respiration and swallowing was expiration-swallow-expiration (EE type) while swallowing 3 ml of water either with or without a cue, swallowing 100 ml of water, and chewing. Although cueing did not affect swallowing movements, the expiratory time was lengthened with the cue. During 100-ml water swallowing, the respiratory cycle time and expiratory time immediately before swallowing were significantly shorter compared with during and after swallowing, whereas the inspiratory time did not differ throughout the recording period. During chewing, the respiratory cycle time was decreased in a time-dependent manner, probably because of metabolic demand. The coordination of the two functions is maintained not only in voluntary swallowing but also in involuntary swallowing during chewing. Understanding the mechanisms underlying respiration and swallowing is important for evaluating how coordination affects physiological swallowing in dysphagic patients.

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  • Impact of Oral and Swallowing Function on the Feeding Status of Older Adults in Nursing Homes. Reviewed International journal

    Sirima Kulvanich, Kayoko Ito, Eri Takei, Haruka Sakai, Risa Suzumi, Jin Magara, Takanori Tsujimura, Makoto Inoue

    Gerontology   67 ( 2 )   168 - 176   2021

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    BACKGROUND: To date, there have been few guidelines proposed for adjustment of the food consistency, particularly to match the oral function of older adults, which will guide clinicians and caregivers in appropriately modifying food. OBJECTIVE: We investigated how oral, swallowing, and cognitive conditions of older adults who required daily nursing care in a nursing home were associated with different dietary food consistencies. METHODS: Clinical examinations to record dentition status, swallowing, and cognitive functions were performed, and the feeding status, including the food consistencies and need for assistance at lunchtime, was evaluated in 37 older residents in nursing homes. The swallowing function was assessed by performing a modified water-swallowing test, and food swallowing was tested using pudding and rice crackers. The χ2 test was used to determine the relationships among the parameters. RESULTS: No participants were able to take cooked rice, nor regular and soft side dishes. There was no significant relationship between dentition status and feeding status. Of the participants, 95% ate pudding without any problems and 49% ate rice crackers without any signs of swallowing difficulty such as coughing or stopping chewing. There was a significant relationship between the food test score using a rice cracker and the level of food consistencies, and between the same test score and the level of mealtime assistance, whereby the better the score of the food test using a rice cracker, the better was the level of food consistencies including use of a thickening agent and the better was the level of mealtime assistance. CONCLUSION: The results strongly suggest that the food test using a rice cracker was associated with the level of food consistency and mealtime assistance for older adults in nursing homes.

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  • Age-related changes in functional adaptation to bolus characteristics during chewing. Reviewed International journal

    Eri Takei, Sirima Kulvanich, Takanori Tsujimura, Jin Magara, Kayoko Ito, Ryo Takei, Hideaki Washio, Hitoshi Arao, Makoto Inoue

    Physiology & behavior   225   113102 - 113102   2020.10

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    We investigated how the physical properties of food affect chewing kinematics, and examined the effects of aging on behavior. Twenty young and 21 older volunteers were asked to freely chew rice crackers and spit the food out at their average chewing duration. We compared chewing characteristics among the conditions (age × rice cracker), and examined the area of rectified masseter and suprahyoid electromyographic bursts per chewing cycle. We also evaluated temporal changes in those values. In addition, the bolus properties at the end of chewing were compared. The harder/larger the rice cracker, the longer the chewing duration and the greater the number of chewing cycles. These values also increased with age. Chewing cycle time was not affected by age and rice cracker properties, except in one condition: for the rice cracker with the lowest hardness and density, the chewing cycle time was longer than for the other rice crackers. Chewing cycle time decreased at the middle stage of chewing, followed by an increase, with increasing suprahyoid electromyographic activity at the late stage. The physical properties of the bolus at the end of chewing did not differ between age groups, and depended on the initial properties. The water absorption rate of the bolus was significantly greater for the rice cracker with the lowest hardness and density compared with other rice crackers. The results demonstrated that not only hardness, but also other factors, such as density, significantly affected chewing behaviors.

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  • Sustained laryngeal transient receptor potential vanilloid 1 activation inhibits mechanically-induced swallowing in anesthetized rats. Reviewed International journal

    Midori Yoshihara, Takanori Tsujimura, Taku Suzuki, Kouta Nagoya, Naru Shiraishi, Jin Magara, Miho Terunuma, Makoto Inoue

    American journal of physiology. Gastrointestinal and liver physiology   319 ( 3 )   G412-G419   2020.8

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    A major component of gastric acid is hydrochloric acid (HCl), which can activate transient receptor potential vanilloid 1 (TRPV1). In the present study, we investigated how sustained laryngeal TRPV1 activation affects the frequency of the swallowing reflex. Experiments were carried out on 85 male Sprague-Dawley rats. The effects of short and sustained application of chemicals (3 µl of 0.1 N HCl or capsaicin) on the frequency of swallowing and of time-dependent changes in the occurrence of swallowing evoked by supralaryngeal nerve stimulation were determined. To evaluate vascular permeability of the larynx, Evans blue dye was intravenously injected after 5 or 60 min of sustained TRPV1 activation. SB366791 (a TRPV1 inhibitor) and Cap/QX-314 (a TRPV1-expressed neuronal inhibitor) significantly inhibited HCl/capsaicin-induced swallowing, but air flow-induced swallowing was not affected. Although the number of air flow-induced swallows induced by capsaicin stimulation was not affected within 5 min, but significantly reduced by 60-min capsaicin or HCl application. The swallowing threshold associated with supralaryngeal nerve stimulation did not significantly change throughout the recording period. Evans blue dye concentrations in the larynx were significantly higher at 60 min in the 10-5 M capsaicin group than in the other groups. Our results suggest that sustained TPRV1 activation not only desensitizes TRPV1, but also inactivates mechanoreceptors, which may be attributed to increases in vascular permeability and edema, as part of an inflammatory process.

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  • Endurance measurement of hyoid muscle activity and hyoid-laryngeal position during tongue lift movement. Reviewed International journal

    Yukako Sunada, Jin Magara, Takanori Tsujimura, Kazuhiro Ono, Makoto Inoue

    Journal of oral rehabilitation   47 ( 8 )   967 - 976   2020.8

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    BACKGROUND: Tongue lift movement (TLM) is used as a therapy to improve tongue pressure against the hard palate for dysphagic patients. OBJECTIVE: The present study aimed to characterize the time-dependent endurance changes in hyoid muscle activity and hyoid-laryngeal displacement during TLM in different ways. METHODS: Sixteen young healthy volunteers were instructed to perform TLM at maximum effort (100%) against the anterior and posterior parts of the hard palate using a balloon-type tongue pressure instrument, followed by a 10-second recording during anterior 80% TLM, anterior 100% TLM, posterior 80% TLM and posterior 100% TLM with visual feedback. Electromyography (EMG) of suprahyoid (S-Hyo) and infrahyoid (I-Hyo) muscles and videofluorography were simultaneously recorded. To evaluate temporal changes, the recording period was divided into three substages: early, middle and late. Tongue pressure, integrated EMG (iEMG), power frequency of EMG burst and hyoid-laryngeal position were compared among the conditions (80% vs 100%, anterior vs posterior and early vs middle vs late). RESULTS: Tongue pressure was stably maintained for 10 seconds in all conditions. S-Hyo iEMG and I-Hyo iEMG were significantly greater at 100% than at 80%, while no significant difference was observed between positions. S-Hyo iEMG and I-Hyo iEMG significantly increased at the late stage, while power frequency of EMG burst gradually decreased. Significant temporal changes in laryngeal elevation were observed only in posterior 100% TLM. CONCLUSION: The current results suggested that isometric posterior TLM may be more useful compared with anterior TLM in clinical situations for dysphagic patients to elevate the hyolaryngeal complex.

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  • Inter-individual variation of bolus properties in triggering swallowing during chewing in healthy humans. Reviewed International journal

    Rumiko Maeda, Eri Takei, Kayoko Ito, Jin Magara, Takanori Tsujimura, Makoto Inoue

    Journal of oral rehabilitation   47 ( 9 )   1161 - 1170   2020.7

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    BACKGROUND: There is a wide variation of chewing behaviors even in healthy humans. The present study was aimed to clarify how the rheological properties of the bolus during chewing is different among individuals. We also investigated if the swallowing threshold was consistent among the individuals and if the difference in the bolus properties at the swallowing affected swallowing movement. METHODS: Twenty-nine healthy volunteers were asked to ingest 8 g of steamed rice. Based on the chewing duration defined by the time until first swallow, participants were asked to chew the food, then either spit it out, or swallow it, at 50%, 100% and 150% of chewing duration. In seven volunteers, the maximum bite force was measured. RESULTS: The hardness of the bolus gradually decreased throughout recording. Although the chewing duration varied widely, there was a significant negative correlation between time and hardness, regardless of the difference in individual chewing duration. The cohesiveness of the bolus was unchanged at the 100% time point, followed by a slight but significant increase. There was no significant correlation between the chewing duration and adhesiveness of the bolus. Swallowing-related bursts of Supra and Infra EMGs were not related to the chewing duration or bolus properties, and chewing duration did not affect swallowing function. CONCLUSION: The current results suggest that the bolus properties such as the hardness and cohesiveness during chewing is just dependent on the chewing duration and the difference in the bolus properties does not affect the swallowing initiation and movement.

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  • Properties of hyoid muscle contraction during tongue lift measurement. Reviewed International journal

    Naomi Koshi, Jin Magara, Shogo Sakai, Takanori Tsujimura, Kazuhiro Ono, Makoto Inoue

    Journal of oral rehabilitation   47 ( 3 )   332 - 338   2020.3

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    BACKGROUND: Tongue lift movement (TLM) task is considered a treatment strategy in dysphagic patients. However, there is no evidence of effect of sustained tongue movements on the related muscle contraction. OBJECTIVES: The present study aimed to characterise the properties and time-dependent changes of the electromyographic (EMG) features of suprahyoid muscles during TLM. METHODS: Twenty young healthy volunteers were instructed to perform TLM at maximum effort in either the anterior or the posterior position, during measurement of tongue pressure for 7 s. Supra- (S-hyo) and infra-hyoid (I-hyo) EMGs were recorded. The area and power frequency of EMG burst and the area under the curve of tongue pressure were compared among the conditions: trials (1st, 2nd vs 3rd trials); anterior vs posterior TLM; and early vs late 3 s of each trial. RESULTS: There was no difference in the tongue pressure among trials or between the early and late 3 s. Anterior tongue pressure was significantly higher than posterior tongue pressure (P < .001). The area of I-hyo EMG burst was significantly larger (P = .044), and the power frequency of I-hyo EMG burst was significantly smaller (P = .042) during posterior TLM than anterior TLM. A significant difference in the power frequency of both EMG bursts was observed between early and late stages during both anterior (P < .05) and posterior (P < .01) TLM. CONCLUSION: Hyoid muscles may compensate for rapid fatigue of the tongue muscle to maintain tongue pressure by changing their activity pattern during tongue pressure generation.

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  • Evaluation of the association between orofacial pain and dysphagia. Reviewed

    Takanori Tsujimura, Makoto Inoue

    Journal of oral science   62 ( 2 )   156 - 159   2020

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    Swallowing has a vital function in airway protection and is the next step after mastication. Swallowing impairment, which is known as dysphagia, is frequently accompanied by pain. Previous clinical studies have shown that orofacial pain affects swallowing function. Thus, it was hypothesized that orofacial noxious inputs may modulate swallowing function. Previous studies using anesthetized animals has proposed that the facial skin-nucleus tractus solitarii (NTS), masseter muscle-NTS, lingual muscle-NTS, and lingual muscle-paratrigeminal nucleus-NTS pathways may be involved in the inhibition of swallowing caused by facial, masseter, and lingual pain. Moreover, the activation of gamma-aminobutyric acidergic NTS neurons is involved in the inhibition of the swallowing reflex following trigeminal noxious inputs. This review focused on the recent management of dysphagia, neural mechanisms of swallowing, and relationship between orofacial pain and swallowing function. This and other future studies in this field can provide a better understanding of both normal and impaired swallowing and can help develop a new approach to treat patients with dysphagia and orofacial pain.

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  • Comparison of physical properties of voluntary coughing, huffing and swallowing in healthy subjects. Reviewed International journal

    Akiko Yawata, Takanori Tsujimura, Ryosuke Takeishi, Jin Magara, Li Yu, Makoto Inoue

    PloS one   15 ( 12 )   e0242810   2020

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    Coughing, huffing and swallowing protect the airway from aspiration. This study was conducted to compare the physical properties of voluntary coughing, huffing and swallowing in healthy subjects. Ten healthy men were asked to huff, cough and swallow repeatedly. Electromyograms (EMGs) were recorded from the left side of the external oblique (EO), sternocleidomastoid, suprahyoid (SH) and thyrohyoid muscles. Airflow was recorded using a face mask with two-way non-rebreathing valves. The expiratory velocity of huffing and coughing and the SH EMG of all actions presented high intraclass correlation coefficients (> 0.8). The inspiratory and expiratory velocities did not differ significantly between coughing and huffing. The expiratory acceleration of coughing was significantly higher than that of huffing, whereas the expiratory volume of coughing was significantly smaller than that of huffing. The EO EMG of coughing and huffing were significantly larger than that of swallowing. The EO EMG activity during the expiratory phase was significantly higher than that of the other phases of both coughing and huffing. The SH EMG of coughing and huffing were significantly smaller than that of swallowing. Correlation analysis revealed that the expiratory velocity of coughing was strongly positively correlated with that of huffing. The expiratory volume of huffing was significantly positively correlated with hand grip strength. These results suggest that EO and SH muscle activities during huffing or coughing differ those during swallowing, and huffing and coughing may work similarly in expiratory function.

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  • 摂食嚥下リハビリテーションを実施したクロウ・深瀬(POEMS)症候群の1例 Reviewed

    羽尾 直仁, 辻村 恭憲, 白石 成, 井上 誠

    新潟歯学会雑誌   49 ( 1 )   19 - 24   2019.6

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  • Effect of attention on chewing and swallowing behaviors in healthy humans. Reviewed International journal

    Hirokazu Ashiga, Eri Takei, Jin Magara, Ryosuke Takeishi, Takanori Tsujimura, Kouta Nagoya, Makoto Inoue

    Scientific reports   9 ( 1 )   6013 - 6013   2019.4

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    We examined how attention alters chewing and swallowing behaviors. Twenty-one healthy volunteers were asked to freely eat 8 g of steamed rice in three separate trials, and we obtained the average number of chewing cycles (N) and chewing duration (T) prior to the first swallow in each trial. We also conducted an N-limited test, in which participants chewed the food while independently counting the number of chewing cycles and swallowed the food when they reached N, and a T-limited test, in which they chewed the food for T sec and then swallowed. We recorded electromyograms (EMGs) from masseter and suprahyoid muscles and collected videoendoscopic images. In the N-limited test, chewing speed decreased, masseter muscle activity (area under the curve of the rectified EMG burst) per cycle increased, and suprahyoid muscle activity per cycle decreased. In the T-limited test, the chewing speed increased, muscle activities per cycle decreased, and the number of cycles increased. The occurrence frequency of bolus propulsion into the pharynx before swallowing was smaller in the N- and T-limited tests than in the free chewing test. Further, the whiteout time was longer in the T-limited test than in the free chewing test. Attentional chewing changes not only chewing but also swallowing behavior.

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  • Cold thermal oral stimulation produces immediate excitability in human pharyngeal motor cortex Reviewed

    J. Magara, M. Watanabe, T. Tsujimura, S. Hamdy, M. Inoue

    Neurogastroenterology & Motility   e13384   2018.10

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  • Effect of peripherally and cortically evoked swallows on jaw reflex responses in anesthetized rabbits. Reviewed International journal

    Taku Suzuki, Midori Yoshihara, Shogo Sakai, Kojun Tsuji, Kouta Nagoya, Jin Magara, Takanori Tsujimura, Makoto Inoue

    Brain research   1694   19 - 28   2018.9

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    This study aimed to investigate whether the jaw-opening (JOR) and jaw-closing reflexes (JCR) are modulated during not only peripherally, but also centrally, evoked swallowing. Experiments were carried out on 24 adult male Japanese white rabbits. JORs were evoked by trigeminal stimulation at 1 Hz for 30 s. In the middle 10 s, either the superior laryngeal nerve (SLN) or cortical swallowing area (Cx) was simultaneously stimulated to evoke swallowing. The peak-to-peak JOR amplitude was reduced during the middle and late 10-s periods (i.e., during and after SLN or Cx stimulation), and the reduction was dependent on the current intensity of SLN/Cx stimulation: greater SLN/Cx stimulus current resulted in greater JOR inhibition. The reduction rate was significantly greater during Cx stimulation than during SLN stimulation. The amplitude returned to baseline 2 min after 10-s SLN/Cx stimulation. The effect of co-stimulation of SLN and Cx was significantly greater than that of SLN stimulation alone. There were no significant differences in any parameters of the JCR between conditions. These results clearly showed that JOR responses were significantly suppressed, not only during peripherally evoked swallowing but also during centrally evoked swallowing, and that the inhibitory effect is likely to be larger during centrally compared with peripherally evoked swallowing. The functional implications of these results are discussed.

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  • 聴神経腫瘍術後に脳幹・小脳出血を合併し摂食嚥下障害を認めた1症例 Reviewed

    笹 杏奈, 辻 光順, 渡邊 賢礼, 那小屋 公太, 伊藤 加代子, 真柄 仁, 辻村 恭憲, 井上 誠

    新潟歯学会雑誌   48 ( 1 )   37 - 41   2018.6

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  • Involvement of hypoglossal and recurrent laryngeal nerves on swallowing pressure. Reviewed International journal

    Takanori Tsujimura, Taku Suzuki, Midori Yoshihara, Shogo Sakai, Naomi Koshi, Hirokazu Ashiga, Naru Shiraishi, Kojun Tsuji, Jin Magara, Makoto Inoue

    Journal of applied physiology   124 ( 5 )   1148 - 1154   2018.5

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    Swallowing pressure generation is important to ensure safe transport of an ingested bolus without aspiration or leaving residue in the pharynx. To clarify the mechanism, we measured swallowing pressure at the oropharynx (OP), upper esophageal sphincter (UES), and cervical esophagus (CE) using a specially designed manometric catheter in anesthetized rats. A swallow, evoked by punctate mechanical stimulation to the larynx, was identified by recording activation of the suprahyoid and thyrohyoid muscles using electromyography (EMG). Areas under the curve of the swallowing pressure at the OP, UES, and CE from two trials indicated high intrasubject reproducibility. Effects of transecting the hypoglossal nerve (12N) and recurrent laryngeal nerve (RLN) on swallowing were investigated. Following bilateral hypoglossal nerve transection (Bi-12Nx), OP pressure was significantly decreased, and time intervals between peaks of thyrohyoid EMG bursts and OP pressure were significantly shorter. Decreased OP pressure and shortened times between peaks of thyrohyoid EMG bursts and OP pressure following Bi-12Nx were significantly increased and longer, respectively, after covering the hard and soft palates with acrylic material. UES pressure was significantly decreased after bilateral RLN transection compared with that before transection. These results suggest that the 12N and RLN play crucial roles in OP and UES pressure during swallowing, respectively. We speculate that covering the palates with a palatal augmentation prosthesis may reverse the reduced swallowing pressure in patients with 12N or tongue damage by the changes of the sensory information and of the contact between the tongue and a palates. NEW & NOTEWORTHY Hypoglossal nerve transection reduced swallowing pressure at the oropharynx. Covering the hard and soft palates with acrylic material may reverse the reduced swallowing function caused by hypoglossal nerve damage. Recurrent laryngeal nerve transection reduced upper esophageal sphincter negative pressure during swallowing.

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  • Differential Response Pattern of Oropharyngeal Pressure by Bolus and Dry Swallows Reviewed

    Mana Hasegawa, Masayuki Kurose, Keiichiro Okamoto, Yoshiaki Yamada, Takanori Tsujimura, Makoto Inoue, Taisuke Sato, Takatsune Narumi, Noritaka Fujii, Kensuke Yamamura

    Dysphagia   33 ( 1 )   83 - 90   2018.2

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  • Immediate effect of laryngeal surface electrical stimulation on swallowing performance. Reviewed International journal

    Keizo Takahashi, Kazuhiro Hori, Hirokazu Hayashi, Masako Fujiu-Kurachi, Takahiro Ono, Takanori Tsujimura, Jin Magara, Makoto Inoue

    Journal of applied physiology (Bethesda, Md. : 1985)   124 ( 1 )   10 - 15   2018.1

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    Surface electrical stimulation of the laryngeal region is used to improve swallowing in dysphagic patients. However, little is known about how electrical stimulation affects tongue movements and related functions. We investigated the effect of electrical stimulation on tongue pressure and hyoid movement, as well as suprahyoid and infrahyoid muscle activity, in 18 healthy young participants. Electrical stimulation (0.2-ms duration, 80 Hz, 80% of each participant's maximal tolerance) of the laryngeal region was applied. Each subject swallowed 5 ml of barium sulfate liquid 36 times at 10-s intervals. During the middle 2 min, electrical stimulation was delivered. Tongue pressure, electromyographic activity of the suprahyoid and infrahyoid muscles, and videofluorographic images were simultaneously recorded. Tongue pressure during stimulation was significantly lower than before or after stimulation and was significantly greater after stimulation than at baseline. Suprahyoid activity after stimulation was larger than at baseline, while infrahyoid muscle activity did not change. During stimulation, the position of the hyoid at rest was descended, the highest hyoid position was significantly inferior, and the vertical movement was greater than before or after stimulation. After stimulation, the positions of the hyoid at rest and at the maximum elevation were more superior than before stimulation. The deviation of the highest positions of the hyoid before and after stimulation corresponded to the differences in tongue pressures at those times. These results suggest that surface electrical stimulation applied to the laryngeal region during swallowing may facilitate subsequent hyoid movement and tongue pressure generation after stimulation. NEW & NOTEWORTHY Surface electrical stimulation applied to the laryngeal region during swallowing may facilitate subsequent hyoid movement and tongue pressure generation after stimulation. Tongue muscles may contribute to overshot recovery more than hyoid muscles.

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  • Effects of pharyngeal electrical stimulation on swallowing performance. Reviewed International journal

    Ryosuke Takeishi, Jin Magara, Masahiro Watanabe, Takanori Tsujimura, Hirokazu Hayashi, Kazuhiro Hori, Makoto Inoue

    PloS one   13 ( 1 )   e0190608   2018

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    Pharyngeal electrical stimulation (PEStim) has been found to facilitate voluntary swallowing. This study investigated how PEStim contributed to modulation of swallowing function in 15 healthy humans. In the involuntary swallowing test, water was injected onto the pharynx at 0.05 ml/s and the onset latency of the first swallow was measured. In the voluntary swallowing test, subjects swallowed their own saliva as quickly as possible for 30 s and the number of swallows was counted. Voluntary and involuntary swallowing was evaluated before (baseline), immediately after, and every 10 min after 10-min PEStim for 60 min. A voluntary swallowing test with simultaneous 30-s PEStim was also conducted before and 60 min after 10-min PEStim. The number of voluntary swallows with simultaneous PEStim significantly increased over 60 min after 10-min PEStim compared with the baseline. The onset latency of the first swallow in the involuntary swallowing test was not affected by 10-min PEStim. The results suggest that PEStim may have a long-term facilitatory effect on the initiation of voluntary swallowing in healthy humans, but not on peripherally-evoked swallowing. The physiological implications of this modulation are discussed.

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  • Effect of body posture on chewing behaviours in healthy volunteers Reviewed

    T. Iizumi, J. Magara, T. Tsujimura, M. Inoue

    JOURNAL OF ORAL REHABILITATION   44 ( 11 )   835 - 842   2017.11

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  • Impact of oral ingestion on oral health condition in dysphagic inpatients Reviewed

    Tejima Y, Ito K, Magara J, Tsujimura T, Inoue M

    Oral Health and Dental Management   16 ( 1 )   1 - 9   2017

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  • 研修歯科医に対する介護保険施設での口腔ケアおよび摂食指導研修 Reviewed

    船山 さおり, 伊藤 加代子, 堀 一浩, 谷口 裕重, 辻村 恭憲, 中村 由紀, 真柄 仁, 渡邊 賢礼, 林 宏和, 辻 光順, 酒井 翔悟, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌   20 ( 2 )   80 - 85   2016.8

  • Effect of body posture on involuntary swallow in healthy volunteers Reviewed

    Yoshitaka Shiino, Shogo Sakai, Ryosuke Takeishi, Hirokazu Hayashi, Masahiro Watanabe, Takanori Tsujimura, Jin Magara, Kayoko Ito, Tetsu Tsukada, Makoto Inoue

    PHYSIOLOGY & BEHAVIOR   155   250 - 259   2016.3

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  • Changes in jaw muscle activity and the physical properties of foods with different textures during chewing behaviors Reviewed

    Hiroko Iguchi, Jin Magara, Yuki Nakamura, Takanori Tsujimura, Kayoko Ito, Makoto Inoue

    PHYSIOLOGY & BEHAVIOR   152 ( Pt A )   217 - 224   2015.12

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  • Peripheral and central control of swallowing initiation in healthy humans Reviewed

    Seiya Aida, Ryosuke Takeishi, Jin Magara, Masahiro Watanabe, Kayoko Ito, Yuki Nakamura, Takanori Tsujimura, Hirokazu Hayashi, Makoto Inoue

    PHYSIOLOGY & BEHAVIOR   151   404 - 411   2015.11

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  • Suppression of the swallowing reflex by stimulation of the red nucleus Reviewed

    Yoshihide Satoh, Kojun Tsuji, Takanori Tsujimura, Ken'Ichi Ishizuka, Makoto Inoue

    BRAIN RESEARCH BULLETIN   116   25 - 33   2015.7

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    DOI: 10.1016/j.brainresbull.2015.05.007

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  • Changes in the frequency of swallowing during electrical stimulation of superior laryngeal nerve in rats Reviewed

    Kojun Tsuji, Takanori Tsujimura, Jin Magara, Shogo Sakai, Yuki Nakamura, Makoto Inoue

    BRAIN RESEARCH BULLETIN   111   53 - 61   2015.2

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  • 訪問歯科診療および訪問歯科診療見学実習に対する学生の意識調査 Reviewed

    伊藤 加代子, 堀 一浩, 谷口 裕重, 辻村 恭憲, 真柄 仁, 井上 誠

    日本歯科医学教育学会雑誌   30 ( 1 )   20 - 26   2014.4

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  • How do tablet properties influence swallowing behaviours? Reviewed

    Shinya Yamamoto, Hiroshige Taniguchi, Hirokazu Hayashi, Kazuhiro Hori, Takanori Tsujimura, Yuki Nakamura, Hideaki Sato, Makoto Inoue

    Journal of Pharmacy and Pharmacology   66 ( 1 )   32 - 39   2014.1

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  • Effects of pharyngeal water stimulation on swallowing behaviors in healthy humans Reviewed

    Yuki Nakamura, Aya Hatakeyama, Yasuyuki Kitada, Takanori Tsujimura, Hiroshige Taniguchi, Makoto Inoue

    EXPERIMENTAL BRAIN RESEARCH   230 ( 2 )   197 - 205   2013.10

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  • Biomechanics of human tongue movement during bolus compression and swallowing. Reviewed

    Hayashi Hirokazu, Hori Kazuhiro, Taniguchi Hiroshige, Nakamura Yuki, Tsujimura Takanori, Ono Takahiro, Inoue Makoto

    J Oral Sci   55 ( 3 )   191 - 198   2013.9

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  • Differences in Chewing Behavior during Mastication of Foods with Different Textures Reviewed

    Megumi Shiozawa, Hiroshige Taniguchi, Hirokazu Hayashi, Kazuhiro Hori, Takanori Tsujimura, Yuki Nakamura, Kayoko Ito, Makoto Inoue

    Journal of Texture Studies   44 ( 1 )   45 - 55   2013.2

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  • Effects of chewing and swallowing behavior on jaw opening reflex responses in freely feeding rabbits Reviewed

    Aki Yamada, Yuka Kajii, Shogo Sakai, Takanori Tsujimura, Yuki Nakamura, Sajjiv Ariyasinghe, Jin Magara, Makoto Inoue

    NEUROSCIENCE LETTERS   535   73 - 77   2013.2

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  • 要介護高齢者における療養管理指導に関する検討 Reviewed

    近藤 匡晴, 伊藤 加代子, 辻村 恭憲, 堀 一浩, 井上 誠

    新潟歯学会雑誌   42 ( 2 )   89 - 96   2012.12

  • Individual-dependent effects of pharyngeal electrical stimulation on swallowing in healthy humans. Reviewed International journal

    Hideki Tsukano, Hiroshige Taniguchi, Kazuhiro Hori, Takanori Tsujimura, Yuki Nakamura, Makoto Inoue

    Physiology & behavior   106 ( 2 )   218 - 23   2012.5

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    DOI: 10.1016/j.physbeh.2012.02.007

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  • Organization of pERK-immunoreactive cells in trigeminal spinal nucleus caudalis, upper cervical cord, NTS and Pa5 following capsaicin injection into masticatory and swallowing-related muscles in rats Reviewed

    Takanori Tsujimura, Masamichi Shinoda, Kuniya Honda, Suzuro Hitomi, Masaaki Kiyomoto, Shingo Matsuura, Ayano Katagiri, Kojun Tsuji, Makoto Inoue, Yoshi Shiga, Koichi Ituata

    BRAIN RESEARCH   1417   45 - 54   2011.10

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    DOI: 10.1016/j.brainres.2011.08.032

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  • Effects of electrical stimulation of the superior laryngeal nerve on the jaw-opening reflex Reviewed

    Takako Fukuhara, Takanori Tsujimura, Yuka Kajii, Kensuke Yamamura, Makoto Inoue

    BRAIN RESEARCH   1391   44 - 53   2011.5

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    DOI: 10.1016/j.brainres.2011.03.065

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  • Neural mechanisms of swallowing inhibition following noxious orofacial stimulation Invited Reviewed

    Takanori Tsujimura, Makoto Inoue, Koichi Iwata

    Journal of Oral Biosciences   53 ( 2 )   137 - 142   2011

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    DOI: 10.2330/joralbiosci.53.137

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  • Inhibition of swallowing reflex following phosphorylation of extracellular signal-regulated kinase in nucleus tractus solitarii neurons in rats with masseter muscle nociception Reviewed

    Takanori Tsujimura, Junichi Kitagawa, Koichiro Ueda, Koichi Iwata

    NEUROSCIENCE LETTERS   450 ( 3 )   361 - 364   2009.2

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    DOI: 10.1016/j.neulet.2008.12.008

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Books

  • 咀嚼・嚥下機能の評価とトラブルシューティングー窒息・誤嚥性肺炎の危機管理―

    辻村恭憲( Role: Joint author ,  咀嚼と嚥下の制御メカニズム)

    全日本病院出版会  2024.8 

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  • Crosslink言語聴覚療法学テキスト 発声発語・摂食嚥下の解剖・生理学

    ( Role: Joint author ,  咀嚼の生理,咀嚼のパターン形成機構と咀嚼の調節機構)

    メジカルビュー社  2022.12 

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  • 新版 歯学生のための摂食嚥下リハビリテーション学

    ( Role: Joint author ,  咳嗽,嚥下造影検査,病院歯科による摂食嚥下リハビリテーション)

    医歯薬出版株式会社  2019.9 

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  • 新よくわかる顎口腔機能

    辻村 恭憲( Role: Joint author ,  嚥下障害への対応)

    医歯薬出版株式会社  2017.2 

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MISC

  • 島皮質誘発嚥下の応答特性と上喉頭神経誘発嚥下との比較 Invited Reviewed

    辻村恭憲, 井上 誠

    嚥下医学   12 ( 1 )   21 - 28   2023.3

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  • 準備期・口腔期の嚥下障害をきたす疾患と対応 Invited

    辻村恭憲, 井上誠

    Medical Practice   39 ( 7 )   981 - 985   2022.7

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  • 【糖尿病と歯周病・摂食嚥下障害-口を禍の門にしないために-】糖尿病の合併症としての摂食嚥下障害 病態とリハビリテーションの実際 Invited

    辻村恭憲, 井上誠

    糖尿病プラクティス   37 ( 5 )   560 - 564   2020.9

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  • 嚥下時胸骨舌骨筋の機能的役割

    坂 暢晃, Chotirungsan Titi, Pan Charng-Rong, 中嶋 優太, 真柄 仁, 辻村 恭憲, 井上 誠

    新潟歯学会雑誌   53 ( 2 )   102 - 102   2024.1

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  • 当院での摂食嚥下機能回復支援チーム体制の構築

    山田 真子, 落合 勇人, 真柄 仁, 那小屋 公太, 小貫 和佳奈, 坂井 遥, 辻村 恭憲, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌   27 ( 3 )   S271 - S272   2023.12

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  • 唾液分泌量の低下が咀嚼嚥下運動に与える影響 Reviewed

    後藤 理恵, 落合 勇人, Kulvanich Sirima, 辻村 恭憲, 真柄 仁, 竹井 亮, 高橋 肇, 井上 誠

    日本顎口腔機能学会雑誌   28 ( 2 )   78 - 79   2023.3

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  • 口唇閉鎖力低下と口腔機能低下の関連性

    小貫和佳奈, 小貫和佳奈, 真柄仁, 伊藤加代子, 辻村恭憲, 井上誠, 井上誠, 井上誠

    日本老年歯科医学会学術大会(Web)   34th   2023

  • 口腔乾燥がもたらす種々の食品咀嚼運動への影響

    後藤理恵, 落合勇人, 竹井絵理, 真柄仁, 辻村恭憲, 井上誠

    新潟歯学会雑誌   53 ( 1 )   2023

  • 持続的舌圧発揮時の舌筋および舌骨筋群の筋電図学的分析

    板離子, 落合勇人, 小貫和佳奈, 真柄仁, 辻村恭憲, 井上誠

    日本嚥下医学会抄録(Web)   46th   2023

  • 唾液分泌低下及びマーガリン添加がパンの咀嚼・嚥下運動と食塊特性にもたらす影響

    落合勇人, 板離子, 小貫和佳奈, 前川和也, 真柄仁, 辻村恭憲, 井上誠

    日本嚥下医学会抄録(Web)   46th   2023

  • 新たな素材の嚥下調整食品の臨床応用への可能性

    日野 遥香, 鈴木 拓, 板 離子, 坂井 遥, 山田 真子, 前川 和也, 真柄 仁, 辻村 恭憲, 井上 誠

    新潟歯学会雑誌   52 ( 2 )   94 - 94   2022.12

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  • 種々の嚥下調整食品が嚥下動態に与える影響 健常者での検証

    板 離子, 笹 杏奈, 真柄 仁, 辻村 恭憲, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌   26 ( 3 )   S208 - S208   2022.12

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  • 固形食品咀嚼時の食塊形成過程における舌骨上筋群の評価

    笹 杏奈, 羽尾 直仁, 板 離子, 鈴木 拓, 真柄 仁, 辻村 恭憲, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌   26 ( 3 )   S209 - S210   2022.12

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  • 種々の嚥下調整食品が嚥下動態に与える影響 臨床応用への可能性

    日野 遥香, 笹 杏奈, 坂井 遥, 山田 真子, 高波 里帆, 前川 和也, 真柄 仁, 辻村 恭憲, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌   26 ( 3 )   S216 - S216   2022.12

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  • 固形食品の食塊形成過程における舌骨上筋群の機能的役割の検討

    笹 杏奈, 真柄 仁, 辻村 恭憲, 井上 誠

    老年歯科医学   37 ( 2 )   113 - 114   2022.9

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  • 食塊形成過程の新しい評価法の検討

    笹 杏奈, 羽尾 直仁, 真柄 仁, 辻村 恭憲, 井上 誠

    言語聴覚研究   19 ( 3 )   256 - 256   2022.9

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  • 固形食品摂取時の食塊形成過程における舌骨上筋群の機能的役割の検討

    笹 杏奈, 真柄 仁, 辻村 恭憲, 井上 誠

    日本老年歯科医学会総会・学術大会プログラム・抄録集   33回   O6 - 04   2022.6

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  • 筋電図ならびに顎運動軌跡の記録を用いた食塊形成/移送過程の評価

    笹 杏奈, 羽尾 直仁, 真柄 仁, 辻村 恭憲, 井上 誠

    日本顎口腔機能学会雑誌   28 ( 2 )   90 - 91   2022.3

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  • 炭酸飲料における刺激とテクスチャの違いが随意嚥下活動に及ぼす影響

    岩森大, 岩森大, 真柄仁, 小貫和佳奈, 板離子, 辻村恭憲, 井上誠, 井上誠

    新潟歯学会雑誌   52 ( 2 )   2022

  • Relationship between tongue pressure and swallowing disorders in neurodegenerative disease patients

    鈴木拓, 真柄仁, 那小屋公太, 板離子, 辻村恭憲, 井上誠

    日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)   28th   2022

  • Intravenous injection of atropine facilitates initiation of swallows in anaesthetized rats

    中嶋優太, 辻村恭憲, 吉原翠, 那小屋公太, 真柄仁, 井上誠

    日本顎口腔機能学会学術大会プログラム・事前抄録集   68th   2022

  • 唾液分泌抑制がもたらす固形食品摂取時の咀嚼嚥下運動への影響

    落合勇人, 小貫和佳奈, 高田夏佳, 伊藤加代子, 真柄仁, 辻村恭憲, 井上誠

    日本老年歯科医学会学術大会(Web)   33rd   2022

  • 当院外来通院患者に対する口腔機能低下症の評価および管理指導の検討

    小貫和佳奈, 小貫和佳奈, 真柄仁, 伊藤加代子, 辻村恭憲, 井上誠, 井上誠, 井上誠

    日本老年歯科医学会学術大会(Web)   33rd   2022

  • 呼吸、嚥下、咀嚼の協調を探る

    羽尾 直仁, 笹 杏奈, 真柄 仁, 辻村 恭憲, 井上 誠, 筒井 雄平, 中嶋 優太

    日本摂食・嚥下リハビリテーション学会雑誌   25 ( 3 )   S186 - S186   2021.12

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  • 筋電図ならびに顎運動軌跡の記録を用いた食塊形成過程の評価

    笹 杏奈, 羽尾 直仁, 真柄 仁, 辻村 恭憲, 井上 誠

    新潟歯学会雑誌   51 ( 2 )   118 - 118   2021.12

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  • 急性心筋梗塞を発症し、長期挿管後に生じた嚥下障害に対して摂食嚥下リハビリテーションを実施した1例

    高波 里帆, 坂 暢晃, 笹 杏奈, 吉原 翠, 羽尾 直仁, 辻村 恭憲, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌   25 ( 3 )   S124 - S124   2021.12

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  • 併存する疾患のあることが多い高齢者における上部消化管疾患のマネージメント 地域病院における消化器サルコペニア疾患診療の有用性

    上村 博輝, 小島 雄一, 高橋 一也, 高綱 将史, 平野 正明, 政二 文明, 藤田 一, 辻村 恭憲, 小林 太一, 寺井 崇二

    日本消化器病学会甲信越支部例会抄録集   68回   52 - 52   2021.6

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  • 口腔機能低下症患者における口腔機能管理の実施効果

    真柄仁, 小貫和佳奈, 辻村恭憲, 井上誠, 井上誠

    8020公募研究報告書抄録(Web)   2021   2021

  • 麻酔下ラットにおけるAMPA受容体ポジティブアロステリックモジュレーターによる嚥下および呼吸の変調効果

    吉原翠, 那小屋公太, 辻村恭憲, 井上誠

    日本嚥下医学会抄録(Web)   44th   2021

  • 慢性閉塞性肺疾患(COPD)モデルラットにおける嚥下動態の生理学的解析

    那小屋公太, 辻村恭憲, 吉原翠, 井上誠

    日本嚥下医学会抄録(Web)   44th   2021

  • Atropine facilitates initiation of swallowing evoked by distilled water in anaesthetized rats

    中嶋優太, 辻村恭憲, 那小屋公太, 吉原翠, 川田里美, 筒井雄平, 井上誠

    Journal of Oral Biosciences Supplement (Web)   2021   2021

  • Consideration of the assessment methods and cutoff values to diagnose the oral hypofunction.

    小貫和佳奈, 小貫和佳奈, 板離子, 真柄仁, 辻村恭憲, 伊藤加代子, 那小屋公太, 羽尾直仁, 坂井遥, 中嶋優太, 井上誠, 井上誠, 井上誠

    日本口腔リハビリテーション学会学術大会プログラム・抄録集   35th (CD-ROM)   2021

  • Analysis of prognosis of patients with oral hypofunction

    小貫和佳奈, 真柄仁, 辻村恭憲, 伊藤加代子, 坂井遥, 中嶋優太, 坂暢晃, 井上誠, 井上誠, 井上誠

    日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)   26th/27th   2021

  • Survey of the assessment and management for the patients with oral hypofunction

    板離子, 小貫和佳奈, 小貫和佳奈, 真柄仁, 辻村恭憲, 伊藤加代子, 那小屋公太, 羽尾直仁, 坂井遥, 中嶋優太, 井上誠, 井上誠, 井上誠

    日本口腔リハビリテーション学会学術大会プログラム・抄録集   35th (CD-ROM)   2021

  • 下部消化管に出現した合併症により対応に苦慮した皮膚筋炎に伴う嚥下障害の一例

    落合勇人, 落合勇人, 渡邊賢礼, 那小屋公太, 山田真子, 山田真子, 高波里帆, 辻村恭憲, 井上誠, 井上誠, 井上誠

    新潟歯学会雑誌   51 ( 1 )   2021

  • Effects of AMPA receptor positive allosteric modulator on initiation of swallows in anesthetized rats

    吉原翠, 那小屋公太, 辻村恭憲, 井上誠

    Journal of Oral Biosciences Supplement (Web)   2020   2020

  • Physiological analysis of swallowing disorder caused by chronic obstructive pulmonary disease (COPD)

    那小屋公太, 辻村恭憲, 吉原翠, 井上誠

    Journal of Oral Biosciences Supplement (Web)   2020   2020

  • 新潟大学医歯学総合病院歯科における口腔機能低下症の患者統計

    小貫和佳奈, 真柄仁, 辻村恭憲, 伊藤加代子, 渡邊賢礼, 那小屋公太, 船山さおり, 羽尾直仁, 羽尾直仁, 坂井遥, 中嶋優太, 井上誠, 井上誠, 井上誠

    日本口腔リハビリテーション学会雑誌   33 ( 1 )   2020

  • 新潟大学医歯学総合病院歯科における口腔機能低下症の評価と検討

    小貫和佳奈, 真柄仁, 辻村恭憲, 伊藤加代子, 渡邊賢礼, 那小屋公太, 船山さおり, 羽尾直仁, 羽尾直仁, 井上誠, 井上誠, 井上誠

    新潟歯学会雑誌   50 ( 2 )   2020

  • 摂食嚥下リハビリテーションを実施したクロウ・深瀬(POEMS)症候群の1例 Reviewed

    羽尾 直仁, 辻村 恭憲, 白石 成, 井上 誠

    新潟歯学会雑誌   49 ( 1 )   19 - 24   2019.6

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  • 病院から施設まで介入を継続している心原性脳塞栓症の一例

    那小屋公太, 真柄仁, 辻村恭憲, 井上誠

    日本嚥下医学会抄録(Web)   42nd   2019

  • 摂食嚥下障害の臨床普及に向けて(第3報) 摂食嚥下治療登録医養成事業の展開

    真柄 仁, 笹 杏奈, 辻村 恭憲, 竹石 龍右, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌   22 ( 3 )   S190 - S190   2018.12

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  • 舌癌術後の摂食嚥下障害に対し間接訓練ならびに直接訓練を実施した1症例 Reviewed

    小貫 和佳奈, 笹 杏奈, 辻 光順, 渡邊 賢礼, 白石 成, 伊藤 加代子, 真柄 仁, 辻村 恭憲, 井上 誠

    新潟歯学会雑誌   48 ( 1 )   43 - 48   2018.6

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  • 聴神経腫瘍術後に脳幹・小脳出血を合併し摂食嚥下障害を認めた1症例 Reviewed

    笹 杏奈, 辻 光順, 渡邊 賢礼, 那小屋 公太, 伊藤 加代子, 真柄 仁, 辻村 恭憲, 井上 誠

    新潟歯学会雑誌   48 ( 1 )   37 - 41   2018.6

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  • 舌癌術後の摂食嚥下障害に対し間接訓練ならびに直接訓練を実施した1症例 Reviewed

    小貫 和佳奈, 笹 杏奈, 辻 光順, 渡邊 賢礼, 白石 成, 伊藤 加代子, 真柄 仁, 辻村 恭憲, 井上 誠

    新潟歯学会雑誌   48 ( 1 )   43 - 48   2018.6

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  • 摂食嚥下障害の臨床普及に向けて(第1報) 摂食嚥下治療登録医養成研修

    真柄 仁, 古志 奈緒美, 笹 杏奈, 竹石 龍右, 辻村 恭憲, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌   21 ( 3 )   S332 - S332   2017.12

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  • 摂食嚥下障害の臨床普及に向けて(第2報) 嚥下内視鏡セミナー

    古志 奈緒美, 真柄 仁, 辻村 恭憲, 笹 杏奈, 竹石 龍右, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌   21 ( 3 )   S333 - S333   2017.12

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  • 低酸素脳症発症後に嚥下障害を認めた一例 Reviewed

    吉原 翠, 上村 由紀子, 大口 繭美, 砂田 悠香子, 竹内 千華子, 白石 成, 辻村 恭憲, 井上 誠

    新潟歯学会雑誌   47 ( 1 )   33 - 37   2017.6

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  • 最近のトピックス 地域一般住民を対象とした摂食嚥下セミナーの紹介

    伊藤 加代子, 船山 さおり, 辻村 恭憲, 真柄 仁, 辻 光順, 酒井 翔悟, 鈴木 拓, 井上 誠

    新潟歯学会雑誌   46 ( 2 )   95 - 96   2016.12

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  • 小脳橋角部髄膜腫摘出術後に嚥下障害を認めた一例 Reviewed

    鈴木 拓, 神田 知佳, 辻村 恭憲, 堀 一浩, 井上 誠

    新潟歯学会雑誌   45 ( 2 )   81 - 85   2015.12

  • 介護保険施設における本学研修医への口腔ケアおよび摂食指導

    船山 さおり, 伊藤 加代子, 辻村 恭憲, 真柄 仁, 林 宏和, 辻 光順, 酒井 翔悟, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌   19 ( 3 )   S254 - S254   2015.12

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  • 米飯ならびに粥食品の咀嚼嚥下を検証する

    井口 寛子, 林 宏和, 竹石 龍右, 酒井 翔悟, 辻村 恭憲, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌   19 ( 3 )   S286 - S287   2015.12

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  • 摂食嚥下障害患者において経口摂取が口腔環境に与える影響

    手嶋 謡子, 林 宏和, 伊藤 加代子, 辻村 恭憲, 井上 誠

    新潟歯学会雑誌   45 ( 2 )   101 - 101   2015.12

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  • リクライニング角度の違いが摂食嚥下機能に与える影響

    椎野 良隆, 酒井 翔悟, 竹石 龍右, 林 宏和, 塚田 徹, 辻村 恭憲, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌   19 ( 3 )   S81 - S82   2015.12

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  • 当院入院の嚥下障害患者における経口摂取と口腔環境との関係

    手嶋 謡子, 林 宏和, 伊藤 加代子, 辻村 恭憲, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌   19 ( 3 )   S177 - S177   2015.12

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  • 口腔への味溶液刺激がもたらす随意性嚥下への効果 Reviewed

    畠山 文, 中村 由紀, 真柄 仁, 辻村 恭憲, 谷口 裕重, 堀 一浩, 井上 誠

    日本顎口腔機能学会雑誌   20 ( 2 )   106 - 114   2014.3

  • 当院における小児摂食嚥下障害患者における過去5年間の臨床統計

    渡邊賢礼, 中村由紀, 辻村恭憲, 谷口裕重, 堀一浩, 真柄仁, 林宏和, 井上誠

    日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)   20th   2014

  • 経管栄養離脱による口腔内の水分量および微生物量の変化

    岸本 奈月, ステガロユ・ロクサーナ, 柴田 佐都子, 上松 弘幸, 伊藤 加代子, 塚野 英樹, 林 宏和, 住谷 美幸, 真柄 仁, 辻村 恭憲, 中村 由紀, 谷口 裕重, 堀 一浩, 井上 誠, 大内 章嗣

    日本歯科衛生学会雑誌   8 ( 1 )   114 - 114   2013.8

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  • 【在宅静脈経腸栄養 今日の進歩】 (Part-3)誤嚥性肺炎の予防対策 神経難病患者における嚥下時食塊動態の特徴

    谷口 裕重, 堀 一浩, 辻村 恭憲, 下畑 享良, 小山 諭, 井上 誠

    臨床栄養   別冊 ( JCNセレクト8 在宅静脈経腸栄養 今日の進歩 )   70 - 75   2013.8

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  • 当院における摂食・嚥下障害患者の動向調査

    手嶋謡子, 中村由紀, 堀一浩, 谷口裕重, 辻村恭憲, 真柄仁, 林宏和, 塚野英樹, 船山さおり, 神田知佳, 今井春菜, 井上誠

    日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)   19th   2013

  • 錠剤の提供条件は嚥下動態にどのような影響をもたらすか

    山本 真也, 辻村 恭憲, 谷口 裕重, 林 宏和, 堀 一浩, 中村 由紀, 佐藤 英明, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌   16 ( 3 )   S319 - S319   2012.12

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  • 今、臨床の現場で求められることは? 摂食・嚥下リハビリテーションの最前線 差し迫った"地域におけるアプローチ"を考える

    辻村 恭憲, 井上 誠

    The Quintessence   31 ( 1 )   103 - 114   2012.1

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  • 上喉頭神経電気刺激により誘発される嚥下反射の発育変化

    梶井 友佳, 福原 孝子, 中村 由紀, 辻村 恭憲, 井上 誠

    Journal of Oral Biosciences   53 ( Suppl. )   178 - 178   2011.9

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  • 上喉頭神経誘発嚥下に対する2つの皮質咀嚼野刺激の異なる変調効果

    辻村 恭憲, 福原 孝子, 山田 亜紀, 中村 由紀, 岩田 幸一, 井上 誠

    Journal of Oral Biosciences   53 ( Suppl. )   144 - 144   2011.9

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  • 入院患者の歯科的介入の必要性を判断するためのスクリーニング用紙の開発

    塚田 しげみ, 柴田 佐都子, 梶井 友佳, 中村 由紀, 辻村 恭憲, 谷口 裕重, 堀 一浩, Stegaroiu Roxana, 井上 誠, 大内 章嗣

    日本歯科衛生学会雑誌   6 ( 1 )   135 - 135   2011.8

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  • 上喉頭神経刺激に伴う開口反射の変調

    福原 孝子, 辻村 恭憲, 林 宏和, 梶井 友佳, 井上 誠

    新潟歯学会雑誌   40 ( 1 )   99 - 100   2010.6

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  • Changes in the jaw opening reflex responses during feeding

    YAMAMOTO Shinya, FUKUHARA Takako, KAJII Yuka, TSUJIMURA Takanori, INOUE Makoto

    16 ( 2 )   140 - 141   2010.2

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  • Swallowing reflex is inhibited by orofacial noxious stimulation through ERK phosphorylation in NTS and Pa5 neurons in rats

    TSUJIMURA Takanori, IWAKAMI Tomoyo, FUKANO Mika, UEDA Koichiro, IWATA Koichi

    24 ( 1 )   1 - 8   2009.2

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  • 再生下歯槽神経における三叉神経節ニューロン活動の変調

    中川量晴, 武田守, 北川純一, 坪井美行, 辻村恭憲, 植田耕一郎, 松本茂二, 岩田幸一

    Journal of Oral Biosciences   49 ( Supplement )   2007

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Presentations

  • Coordination of respiration, swallowing and chewing in healthy humans Invited

    Takanori Tsujimura, Makoto Inoue

    50th Anniversary Meeting and International Conference of the Korean Academy of Rehabilitation Medicine  2022.10 

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    Event date: 2022.10

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  • 実験動物を用いた嚥下神経機構の解明 Invited

    辻村恭憲, 吉原翠, 井上誠

    第64回日本平滑筋学会総会  2022.7 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 孤束核のグルタミン酸受容体は嚥下誘発に関与する Invited

    辻村恭憲, Brendan J Canning, 井上誠

    第45回嚥下医学会学術講演会  2022.2 

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    Event date: 2022.2

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • Peripheral mechanisms of mechanically evoked swallows Invited

    Takanori Tsujimura, Makoto Inoue

    2nd World Dysphagia Summit  2021.8 

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    Event date: 2021.8

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

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  • 炭酸刺激による嚥下誘発メカニズム Invited

    辻村恭憲, 井上誠

    第26・27回合同学術大会日本摂食嚥下リハビリテーション学会  2021.8 

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    Event date: 2021.8

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 嚥下誘発におけるカプサイシン感受性神経の関与 Invited

    辻村恭憲, 井上 誠

    第30回日本摂食嚥下リハビリテーション学会  2024.8 

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  • The neural mechanisms of initiation of mechanically evoked swallows Invited

    Takanori Tsujimura, Makoto Inoue

    International Symposium on Development of Human Resources in Practical Oral Health and Treatment 2024  2024.6 

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  • 嚥下誘発におけるP2X受容体の関与 Invited

    辻村恭憲, 井上 誠

    第47回日本嚥下医学会学術講演会  2024.2 

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  • Role of P2X receptor on the initiation of swallows in anesthetized rats

    Takanori Tsujimura, Satomi Kawada, Nozomi Dewa, Jin Magara, Makoto Inoue

    The 1st International Conference of Asian Dysphagia Society  2023.11 

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  • 小動物を用いた嚥下神経機構の解明 Invited

    辻村恭憲, 井上 誠

    第33回日本老年学会総会  2023.6 

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  • NMDA and non-NMDA glutamate receptors in the rostral-commissural, medial, and ventrolateral nTS subnuclei are involved in the initiation of swallows in anesthetized guinea pigs

    Takanori Tsujimura, Brendan Canning, Makoto Inoue

    31st Dysphagia Research Society Annual Meeting  2023.3 

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  • Swallowing and Breathing: Implication for Dysphagia Rehabilitation Invited

    Takanori Tsujimura, Makoto Inoue

    The 13th Korean Dysphagia Society Academic Conference and Annual Meeting  2022.11 

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  • 摂食嚥下障害の評価と対応 Invited

    辻村恭憲, 井上, 誠

    日本心臓リハビリテーション学会第4回関東甲信越支部地方会  2019.9 

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  • Peripheral Mechanisms of Mechanically Evoked Swallowing Invited

    Takanori Tsujimura

    International Niigata-Taiwan Universities Collaborative Dental Research Symposium  2019.3 

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  • Involvement of hypoglossal and recurrent laryngeal nerves on swallowing pressure Invited

    Takanori Tsujimura, Makoto Inoue

    The 24th Annual Meeting of the Japanese Society of Dysphagia Rehabilitation The 3rd Japan-Korea Joint Symposium  2018.9 

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  • 筋電図を用いた顎口腔機能計測と臨床応用への期待 Invited

    辻村恭憲, 真柄仁, 井上誠

    第28回 日本摂食嚥下リハビリテーション学会  2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 皮膚筋炎ならびにその合併症により対応に苦慮した嚥下障害の一例

    落合勇人, 渡邊賢礼, 那小屋公太, 山田真子, 辻村恭憲, 井上誠, 井上誠

    日本言語聴覚学会(Web)  2021 

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  • 新潟大学医歯学総合病院歯科における口腔機能低下症の評価と検討

    小貫 和佳奈, 真柄 仁, 辻村 恭憲, 伊藤 加代子, 渡邊 賢礼, 那小屋 公太, 船山 さおり, 羽尾 直仁, 井上 誠

    新潟歯学会雑誌  2020.12  新潟歯学会

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    Event date: 2020.12

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  • 新潟大学医歯学総合病院歯科における口腔機能低下症の患者統計

    小貫 和佳奈, 真柄 仁, 辻村 恭憲, 伊藤 加代子, 渡邊 賢礼, 那小屋 公太, 船山 さおり, 羽尾 直仁, 坂井 遥, 中嶋 優太, 井上 誠

    日本口腔リハビリテーション学会雑誌  2020.12  日本口腔リハビリテーション学会

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  • 慢性閉塞性肺疾患(COPD)に起因する嚥下機能低下の生理学的検証

    那小屋 公太, 辻村 恭憲, 吉原 翠, 井上 誠

    Journal of Oral Biosciences Supplement  2020.9  (一社)歯科基礎医学会

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    Event date: 2020.9

    Language:Japanese  

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  • 麻酔下ラットにおけるAMPA受容体ポジティブアロステリックモジュレーターによる嚥下誘発への効果

    吉原 翠, 那小屋 公太, 辻村 恭憲, 井上 誠

    Journal of Oral Biosciences Supplement  2020.9  (一社)歯科基礎医学会

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    Event date: 2020.9

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  • Coordination between respiration and chewing/swallowing in healthy humans

    羽尾直仁, 笹杏奈, 辻村恭憲, 那小屋公太, 真柄仁, 井上誠

    日本顎口腔機能学会学術大会プログラム・事前抄録集  2020 

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  • 健常者における呼吸と嚥下の協調

    羽尾直仁, 笹杏奈, 辻村恭憲, 那小屋公太, 中嶋優太, 真柄仁, 井上誠

    日本口腔リハビリテーション学会雑誌  2020 

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  • 健常若年者における呼吸と嚥下の協調

    羽尾直仁, 羽尾直仁, 笹杏奈, 辻村恭憲, 那小屋公太, 中嶋優太, 坂暢晃, 後藤理恵, 真柄仁, 井上誠, 井上誠, 井上誠

    新潟歯学会雑誌  2020 

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  • 舌挙上運動時における舌骨筋の機能特性

    古志 奈緒美, 真柄 仁, 辻村 恭憲, 小野 和宏, 井上 誠

    新潟歯学会雑誌  2019.12  新潟歯学会

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    Event date: 2019.12

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  • 米飯摂取時の咀嚼時間の個人差に関する検討

    高地 いづみ, 竹井 絵理, 真柄 仁, 辻村 恭憲, 前田 留美子, 井上 誠

    新潟歯学会雑誌  2019.12  新潟歯学会

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  • 米菓摂取時の咀嚼特性と食塊物性

    竹井 絵理, 真柄 仁, 辻村 恭憲, 井上 誠

    日本顎口腔機能学会雑誌  2019.9  日本顎口腔機能学会

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  • Effect of long-lasting laryngeal TRPV1 activation on initiation of swallowing in anesthetized rats

    吉原翠, 那小屋公太, 真柄仁, 辻村恭憲, 井上誠

    日本顎口腔機能学会雑誌  2019 

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    Event date: 2019

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  • 舌挙上運動時における舌骨喉頭位と舌骨筋活動の評価

    砂田 悠香子, 真柄 仁, 竹石 龍右, 辻村 恭憲, 井上 誠

    新潟歯学会雑誌  2018.12  新潟歯学会

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    Event date: 2018.12

    Language:Japanese  

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  • 介護食品および介護食器具等に関する情報提供

    伊藤 加代子, 辻村 恭憲, 真柄 仁, 井上 誠

    日本口腔リハビリテーション学会雑誌  2018.12  日本口腔リハビリテーション学会

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    Language:Japanese  

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  • 米菓摂取時の筋活動と食塊物性

    竹井 絵理, 竹井 亮, 鷲尾 英明, 真柄 仁, 辻村 恭憲, 井上 誠

    日本咀嚼学会雑誌  2018.11  (NPO)日本咀嚼学会

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    Language:Japanese  

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  • 米飯摂取時の食塊物性と筋活動特性

    竹井 絵理, 前田 留美子, 真柄 仁, 辻村 恭憲, 竹石 龍右, 井上 誠

    日本顎口腔機能学会雑誌  2018.9  日本顎口腔機能学会

  • 若手の口腔生理学研究最前線 嚥下反射の誘発に関わる末梢の受容機構

    吉原 翠, 鈴木 拓, 那小屋 公太, 辻村 恭憲, 井上 誠

    Journal of Oral Biosciences Supplement  2018.9  (一社)歯科基礎医学会

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    Event date: 2018.9

    Language:Japanese  

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  • 咀嚼がもたらす摂食嚥下機能への影響

    井上 誠, 辻村 恭憲, 真柄 仁

    日本老年歯科医学会総会・学術大会プログラム・抄録集  2018.6  (一社)日本老年歯科医学会

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    Event date: 2018.6

    Language:Japanese  

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  • 舌癌術後の摂食嚥下障害に対し間接訓練ならびに直接訓練を実施した1症例

    小貫 和佳奈, 笹 杏奈, 辻 光順, 渡邊 賢礼, 白石 成, 伊藤 加代子, 真柄 仁, 辻村 恭憲, 井上 誠

    新潟歯学会雑誌  2018.6  新潟歯学会

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    頭頸部癌術後は、高頻度に摂食嚥下障害を生じる。今回、舌癌術後に摂食嚥下障害を生じ、リハビリテーションによる食形態や姿勢の調整によって経口摂取が可能となった症例を経験したので報告する。症例は68歳の男性。舌亜全摘術、両側頸部郭清術、腹直筋皮弁再建術、気管切開術、胃瘻造設術後、放射線治療開始と同時にN大学医歯学総合病院摂食嚥下機能回復部に紹介受診となった。初診時、頸部拘縮、舌切除による創部瘢痕化を伴う口腔移送不良・鼻咽腔閉鎖不全・咽頭収縮不全を認めた。嚥下内視鏡検査と嚥下造影検査により、リクライニング60度、左側臥位・右側頸部回旋位にてとろみ付液体2ccの食道流入が可能なことを確認して、毎日の間接訓練および代償法を用いた直接訓練を開始した。術後放射線治療の影響による口腔粘膜炎は自制内であり、訓練手技を獲得して耐久性が向上した介入29日目より食事開始、介入35日目には口腔移送改善を目的として舌接触補助床を用いた訓練を開始したものの、違和感や嘔気が強く常時使用にはいたらなかった。今後は、経口摂取のみでの栄養確保、歯科補綴学的アプローチによる口腔準備期の改善も可能であると考えている。(著者抄録)

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  • 咀嚼の意識化による咀嚼および嚥下の変調について

    阿志賀 大和, 鈴木 拓, 真柄 仁, 竹石 龍右, 辻村 恭憲, 井上 誠

    日本顎口腔機能学会雑誌  2018.3  日本顎口腔機能学会

  • 米飯咀嚼時の食塊形成と嚥下誘発の関係

    前田 留美子, 竹井 絵理, 真柄 仁, 辻村 恭憲, 竹石 龍右, 井上 誠

    日本顎口腔機能学会雑誌  2018.3  日本顎口腔機能学会

  • 嚥下誘発におけるカプサイシン感受性神経の役割 Invited

    辻村恭憲, 辻 光順, 井上 誠

    第41回嚥下医学会学術講演会  2018.2 

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    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 摂食嚥下障害の臨床普及に向けて 第3報 摂食嚥下治療登録医養成事業の展開

    真柄仁, 真柄仁, 笹杏奈, 辻村恭憲, 竹石龍右, 井上誠, 井上誠

    日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)  2018 

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  • 嚥下反射の誘発に関わる末梢の受容機構

    吉原翠, 鈴木拓, 那小屋公太, 辻村恭憲, 井上誠

    Journal of Oral Biosciences Supplement (Web)  2018 

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  • 咀嚼時米飯の物性変化は嚥下誘発をどのように決定するか

    前田 留美子, 竹井 絵理, 真柄 仁, 辻村 恭憲, 竹石 龍右, 井上 誠

    新潟歯学会雑誌  2017.12  新潟歯学会

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    Event date: 2017.12

    Language:Japanese  

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  • 咀嚼の意識化による摂食嚥下運動の変化

    阿志賀 大和, 鈴木 拓, 真柄 仁, 竹石 龍右, 辻村 恭憲, 井上 誠

    新潟歯学会雑誌  2017.12  新潟歯学会

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  • 口腔への温度刺激がもたらす嚥下機能への影響

    吉原 翠, 竹内 千華子, 竹石 龍右, 伊藤 加代子, 真柄 仁, 辻村 恭憲, 井上 誠

    日本顎口腔機能学会雑誌  2017.9  日本顎口腔機能学会

  • 舌圧測定時における舌骨筋群の筋電図学的分析

    古志 奈緒美, 真柄 仁, 酒井 翔悟, 鈴木 拓, 辻村 恭憲, 井上 誠

    日本顎口腔機能学会雑誌  2017.9  日本顎口腔機能学会

  • 嚥下が顎反射に与える影響

    鈴木 拓, 吉原 翠, 辻 光順, 真柄 仁, 辻村 恭憲, 井上 誠

    Journal of Oral Biosciences Supplement  2017.9  (一社)歯科基礎医学会

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  • 健常成人の舌挙上運動時における舌骨筋群の筋活動動態の検討

    古志 奈緒美, 真柄 仁, 酒井 翔梧, 鈴木 拓, 辻村 恭憲, 井上 誠

    言語聴覚研究  2017.9  (一社)日本言語聴覚士協会

  • 口腔内への温度刺激がもたらす咽頭皮質延髄路の変調

    真柄 仁, 渡邊 賢礼, 酒井 翔悟, 鈴木 拓, 辻村 恭憲, 井上 誠

    嚥下医学  2017.9  日本嚥下医学会

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  • 低酸素脳症発症後に嚥下障害を認めた一例

    吉原 翠, 上村 由紀子, 大口 繭美, 砂田 悠香子, 竹内 千華子, 白石 成, 辻村 恭憲, 井上 誠

    新潟歯学会雑誌  2017.6  新潟歯学会

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    低酸素脳症発症後に嚥下障害を認めた一例を報告する。症例は69歳女性。2015年11月より右気胸にて当院呼吸器感染症内科に入院した。入院6日目に院内で緊張性気胸を再発し、心肺停止に伴う低酸素脳症を発症した。発症58日目に意識レベルの改善を認め、嚥下機能評価のため当科初診となった。指示理解不良で意識レベルはJCS I-3であり、口腔衛生状態は不良で、残存歯は少ないが義歯使用により咬合支持が得られる状態であった。発声・腹式呼吸は不可だった。顎舌顔面の感覚あるものの、舌運動は不良で、呼吸状態不良につき頬ふくらまし・吸引は不可だった。頸部運動は不良で、反復唾液嚥下テストは0回だった。介入3日目(発症60日目)、嚥下内視鏡検査を実施した。安静時より咽頭に分泌物の貯留あり。とろみ摂取時には、喉頭侵入および咽頭残留があったものの誤嚥は認められなかった。先行期から嚥下咽頭期にわたる機能的嚥下障害と診断し、口腔ケア・間接訓練から介入を開始した。呼吸状態安定時のみ少量の直接訓練を実施した。介入57日目(発症114日目)には、義歯調整を行った後に、嚥下造影検査を実施した。液体・ゆるめのとろみにて声門上まで喉頭侵入し、固形物は喉頭蓋谷及び舌背に残留を認めた。ティースプーン一杯量を摂取した際に、患者は咽頭残留を自覚できた。食事による訓練が可能と判断し、全粥・半固形食とろみ付きの食事を開始した。並行して舌運動訓練を実施し、最終的に全粥・半固形食を3食摂取可能となった。(著者抄録)

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  • 嚥下時の顎反射の変調

    鈴木 拓, 酒井 翔悟, 辻 光順, 真柄 仁, 辻村 恭憲, 井上 誠

    日本顎口腔機能学会雑誌  2017.3  日本顎口腔機能学会

  • 摂食嚥下障害の臨床普及に向けて 第1報 摂食嚥下治療登録医養成研修

    真柄仁, 真柄仁, 古志奈緒美, 笹杏奈, 竹石龍右, 辻村恭憲, 井上誠

    日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)  2017 

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  • 摂食嚥下障害の臨床普及に向けて 第2報 嚥下内視鏡セミナー

    古志奈緒美, 真柄仁, 辻村恭憲, 笹杏奈, 竹石龍右, 井上誠

    日本摂食嚥下リハビリテーション学会学術大会抄録集(Web)  2017 

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  • Blockade of swallow initiation evoked by capsaicin following co-application of QX-314 and capsaicin in anesthetized rats

    Kojun Tsuji, Takanori Tsujimura, Shogo Sakai, Taku Suzuki, Jin Magara, Makoto Inoue

    CHEMICAL SENSES  2016.11  OXFORD UNIV PRESS

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  • Role of ENaC in initiation of swallows in anesthetized rats

    Takanori Tsujimura, Kojun Tsuji, Shogo Sakai, Taku Suzuki, Jin Magara, Makoto Inoue

    CHEMICAL SENSES  2016.11  OXFORD UNIV PRESS

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    Language:English  

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  • 口腔顔面領域の感覚 運動機能の統合 嚥下機能の理解から治療戦略へ

    井上 誠, 辻村 恭憲, 真柄 仁, 辻 光順

    Journal of Oral Biosciences Supplement  2016.9  (一社)歯科基礎医学会

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    Event date: 2016.9

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  • 口腔ケア介入患者の肺炎発症に関係する因子

    堀川 奈穂美, 堀 一浩, 伊藤 加代子, 辻村 恭憲, 真柄 仁, 船山 さおり, 酒井 翔悟, 小野 高裕, 井上 誠

    老年歯科医学  2016.9  (一社)日本老年歯科医学会

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  • 疾患別にみた舌圧発現の特徴

    真柄 仁, 辻 光順, 林 宏和, 辻村 恭憲, 堀 一浩, 井上 誠

    嚥下医学  2016.9  日本嚥下医学会

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  • 孤束核グルタミン酸受容体は嚥下誘発に関与する

    辻村 恭憲, 辻 光順, 酒井 翔悟, 鈴木 拓, 真柄 仁, 井上 誠

    嚥下医学  2016.9  日本嚥下医学会

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  • 研修歯科医に対する介護保険施設での口腔ケアおよび摂食指導研修

    船山 さおり, 伊藤 加代子, 堀 一浩, 谷口 裕重, 辻村 恭憲, 中村 由紀, 真柄 仁, 渡邊 賢礼, 林 宏和, 辻 光順, 酒井 翔悟, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌  2016.8  (一社)日本摂食嚥下リハビリテーション学会

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    Event date: 2016.8

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  • 口腔ケア介入患者の肺炎発症に関係する因子

    堀川 奈穂美, 堀 一浩, 加藤 加代子, 辻村 恭憲, 真柄 仁, 船山 さおり, 酒井 翔悟, 小野 高裕, 井上 誠

    日本老年歯科医学会総会・学術大会プログラム・抄録集  2016.6  (一社)日本老年歯科医学会

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  • 口腔への温度刺激がもたらす嚥下機能への影響

    神田 知佳, 竹石 龍右, 真柄 仁, 辻村 恭憲, 井上 誠

    日本顎口腔機能学会雑誌  2016.3  日本顎口腔機能学会

  • 上喉頭神経刺激による口腔感覚の変調

    酒井 翔悟, 辻 光順, 真柄 仁, 辻村 恭憲, 井上 誠

    日本顎口腔機能学会雑誌  2015.9  日本顎口腔機能学会

  • 口腔生理学分野の研究最前線Frontier in the field of Oral Physiology 嚥下時における口腔感覚の変調

    酒井 翔悟, 辻 光順, 真柄 仁, 辻村 恭憲, 井上 誠

    Journal of Oral Biosciences Supplement  2015.9  (一社)歯科基礎医学会

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  • 咽頭粘膜への電気刺激がもたらす嚥下機能への即時および長期効果

    井上 誠, 竹石 龍右, 渡邉 賢礼, 真柄 仁, 林 宏和, 辻村 恭憲, 堀 一浩

    嚥下医学  2015.9  日本嚥下医学会

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  • 咽頭電気刺激による嚥下機能への驚くべき効果

    林 宏和, 竹石 龍右, 真柄 仁, 谷口 裕重, 辻村 恭憲, 堀 一浩, 井上 誠

    日本顎口腔機能学会雑誌  2015.3  日本顎口腔機能学会

  • 上喉頭神経刺激時の開口反射の変調とそのメカニズムの解明

    酒井 翔悟, 辻 光順, 真柄 仁, 辻村 恭憲, 井上 誠

    新潟歯学会雑誌  2014.12  新潟歯学会

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    Language:Japanese  

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  • ヒト咽頭粘膜への電気刺激がもたらす嚥下機能の可塑性変化

    竹石 龍右, 真柄 仁, 谷口 裕重, 林 宏和, 辻村 恭憲, 堀 一浩, 井上 誠

    新潟歯学会雑誌  2014.12  新潟歯学会

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  • ガム咀嚼運動が嚥下反射惹起に与える影響

    谷口 裕重, 堀 一浩, 林 宏和, 辻村 恭憲, 真柄 仁, 竹石 龍右, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌  2014.12  (一社)日本摂食嚥下リハビリテーション学会

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  • ヒト咽頭粘膜への電気刺激がもたらす嚥下機能の神経可塑性変化

    竹石 龍右, 真柄 仁, 谷口 裕重, 林 宏和, 辻村 恭憲, 堀 一浩, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌  2014.12  (一社)日本摂食嚥下リハビリテーション学会

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  • 当院における小児摂食嚥下障害患者における過去5年間の臨床統計

    渡邊 賢礼, 中村 由紀, 辻村 恭憲, 谷口 裕重, 堀 一浩, 真柄 仁, 林 宏和, 井上 誠

    日本摂食・嚥下リハビリテーション学会雑誌  2014.12  (一社)日本摂食嚥下リハビリテーション学会

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  • 嚥下時における顎反射の変調とそのメカニズム

    酒井 翔悟, 辻 光順, 真柄 仁, 辻村 恭憲, 井上 誠

    日本顎口腔機能学会雑誌  2014.9  日本顎口腔機能学会

  • 咽頭電気刺激がもたらす嚥下関連機能の神経可塑性変化

    真柄 仁, 谷口 裕重, 林 宏和, 竹石 龍右, 辻村 恭憲, 堀 一浩, 井上 誠

    日本顎口腔機能学会雑誌  2014.9  日本顎口腔機能学会

  • 咀嚼運動が嚥下反射に与える影響

    谷口 裕重, 堀 一浩, 林 宏和, 辻村 恭憲, 真柄 仁, 井上 誠

    老年歯科医学  2014.9  (一社)日本老年歯科医学会

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    Event date: 2014.9

    Language:Japanese  

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  • 嚥下誘発における孤束核グルタミン酸受容体の役割(The role of glutamate receptors in the nucleus of the solitary tract of the intitation of swallows)

    辻村 恭憲, 辻 光順, 酒井 翔悟, 真柄 仁, 井上 誠

    Journal of Oral Biosciences Supplement  2014.9  (一社)歯科基礎医学会

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    Event date: 2014.9

    Language:English  

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  • 上喉頭神経刺激時における開口反射と三叉神経核領域での神経伝達の変調への影響

    酒井 翔悟, 辻 光順, 真柄 仁, 辻村 恭憲, 井上 誠

    Journal of Oral Biosciences Supplement  2014.9  (一社)歯科基礎医学会

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    Event date: 2014.9

    Language:Japanese  

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  • 咀嚼運動が嚥下反射に与える影響

    谷口 裕重, 堀 一浩, 林 宏和, 辻村 恭憲, 真柄 仁, 井上 誠

    日本老年歯科医学会総会・学術大会プログラム・抄録集  2014.6  (一社)日本老年歯科医学会

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    Event date: 2014.6

    Language:Japanese  

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  • 口腔への味溶液刺激がもたらす随意性嚥下への効果

    畠山 文, 中村 由紀, 真柄 仁, 辻村 恭憲, 谷口 裕重, 堀 一浩, 井上 誠

    日本顎口腔機能学会雑誌  2014.3  日本顎口腔機能学会

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    Event date: 2014.3

    Language:Japanese  

    味覚刺激が嚥下運動にどのような変化を与えるかについて調べることを目的として、異なる濃度の塩味またはうま味溶液を口腔内に微量注入した時の随意性嚥下運動を記録した。健常成人29名を対象として、出来るだけ早く繰り返し嚥下するよう指示し、その際に咽頭または口腔への溶液刺激(0.2mL/min)を与えた。咽頭への溶液刺激は蒸留水または0.3 M NaCl溶液とし、口腔への溶液刺激は蒸留水または3種類のNaイオン濃度(6mM、40mM、240mM)のうま味溶液(モル濃度比2対1のグルタミン酸ナトリウムとイノシン酸ナトリウム混合溶液)、うま味溶液と同濃度のNaイオンを含むNaCl溶液とした。測定開始後4から9回目までの各嚥下間の平均時間を嚥下間隔時間として各条件間で比較した。NaCl溶液、蒸留水いずれの咽頭刺激においても嚥下間隔時間の顕著な個人差が認められた。NaCl溶液刺激時の嚥下間隔時間は蒸留水よりも有意に長く、咽頭の水受容器による嚥下反射誘発促進効果、NaCl溶液による水受容器応答の抑制が確認された。さらにNaCl溶液刺激時の嚥下間隔時間が長い被験者ほど蒸留水刺激による随意性嚥下の促進効果が高かった。一方、口腔への溶液刺激では、うま味溶液刺激時のみ蒸留水に対して有意な短縮を認めた。随意性嚥下能力の高い順から上位群、中位群、下位群ごとに嚥下間隔時間の変化を調べたところ、上位群、下位群では各溶液の濃度の違いによる有意な差は認められなかったのに対して、中位群のみ溶液濃度が高くなるに従って嚥下間隔時間の短縮を認めた。以上の結果は、中位群におけるうま味成分がもつ随意性嚥下への促進効果を示唆するものである。随意性嚥下誘発能力の個人差をもとに、末梢入力に対する嚥下運動誘発の時間間隔を比較したところ、咽頭刺激時とは異なっていたことから、口腔への味覚刺激がもつ嚥下中枢への効果は単なる加重効果として捉えられず、その効果の作用機序の理解に向けてはさらなる議論が必要である。(著者抄録)

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  • 麻酔下ラットにおける上喉頭神経連続電気刺激時の嚥下反射誘発の減衰

    辻 光順, 辻村 恭憲, 酒井 翔悟, 真柄 仁, 井上 誠

    新潟歯学会雑誌  2013.12  新潟歯学会

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    Language:Japanese  

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  • 麻酔下ウサギにおける自律神経活動変化が及ぼす開口反射への影響

    酒井 翔悟, 辻 光順, 真柄 仁, 辻村 恭憲, 井上 誠

    Journal of Oral Biosciences Supplement  2013.9  (一社)歯科基礎医学会

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    Event date: 2013.9

    Language:Japanese  

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  • 経管栄養離脱による口腔内の水分量および微生物量の変化

    岸本 奈月, ステガロユ・ロクサーナ, 柴田 佐都子, 上松 弘幸, 伊藤 加代子, 塚野 英樹, 林 宏和, 住谷 美幸, 真柄 仁, 辻村 恭憲, 中村 由紀, 谷口 裕重, 堀 一浩, 井上 誠, 大内 章嗣

    日本歯科衛生学会雑誌  2013.8  日本歯科衛生学会

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    Event date: 2013.8

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  • Evidence for swallowing reflexes evoked by acid and mechanical stimulation of the vagal afferent nerves innervating the larynx in anesthetized guinea pigs

    Takanori Tsujimura, Brendan J. Canning

    FASEB JOURNAL  2013.4  FEDERATION AMER SOC EXP BIOL

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    Event date: 2013.4

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  • 自由行動下ウサギにおける開口反射の変調

    山田 亜紀, 辻村 恭憲, 梶井 友佳, 福原 孝子, 井上 誠

    新潟歯学会雑誌  2012.6  新潟歯学会

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    Event date: 2012.6

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  • 上喉頭神経への電気刺激時にみられる開口反射の変調と自律神経活動との関係

    福原 孝子, 梶井 友佳, 辻村 恭憲, 山田 亜紀, 井上 誠

    Journal of Oral Biosciences  2011.9  (一社)歯科基礎医学会

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    Event date: 2011.9

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  • 上喉頭神経電気刺激により誘発される嚥下反射の発育変化

    梶井 友佳, 福原 孝子, 中村 由紀, 辻村 恭憲, 井上 誠

    Journal of Oral Biosciences  2011.9  (一社)歯科基礎医学会

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  • 上喉頭神経誘発嚥下に対する2つの皮質咀嚼野刺激の異なる変調効果

    辻村 恭憲, 福原 孝子, 山田 亜紀, 中村 由紀, 岩田 幸一, 井上 誠

    Journal of Oral Biosciences  2011.9  (一社)歯科基礎医学会

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    Event date: 2011.9

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  • 入院患者の歯科的介入の必要性を判断するためのスクリーニング用紙の開発

    塚田 しげみ, 柴田 佐都子, 梶井 友佳, 中村 由紀, 辻村 恭憲, 谷口 裕重, 堀 一浩, Stegaroiu Roxana, 井上 誠, 大内 章嗣

    日本歯科衛生学会雑誌  2011.8  日本歯科衛生学会

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    Event date: 2011.8

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  • Effects of afferent inputs from superior laryngeal nerve on the jaw opening reflex responses

    Takako Fukuhara, Takanori Tsujimura, Yuka Kajii, Hirokazu Hayashi, Makoto Inoue

    JOURNAL OF PHYSIOLOGICAL SCIENCES  2010  SPRINGER TOKYO

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    Event date: 2010

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  • Involvement of NTS nociceptive neurons in an inhibition of swallows following orofacial noxious stimulation

    Takanori Tsujimura, Takako Fukuhara, Yuka Kajii, Koichi Iwata, Makoto Inoue

    JOURNAL OF PHYSIOLOGICAL SCIENCES  2010  SPRINGER TOKYO

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    Event date: 2010

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  • Brainstem neurons receiving inputs from the superior laryngeal nerve and their involvements in the swallowing

    Makoto Inoue, Takanori Tsujimura, Takako Fukuhara, Yuka Kajii

    JOURNAL OF PHYSIOLOGICAL SCIENCES  2010  SPRINGER TOKYO

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    Event date: 2010

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  • INVOLVEMENT OF ERK PHOSPHORYLATION IN BRAINSTEM NEURONS IN MODULATION OF SWALLOWING REFLEX IN RATS

    Takanori Tsujimura, Masahiro Kondo, Junichi Kitagawa, Yoshiyuki Tsuboi, Koichiro Ueda, Koichi Iwata

    JOURNAL OF PHYSIOLOGICAL SCIENCES  2009  SPRINGER TOKYO

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    Event date: 2009

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  • Mechanisms of swallowing initiation and its impairment Invited

    Takanori Tsujimura

    International Collaborative Symposium on Development of Human Resources in Practical Oral Health and Treatment 2023  2023.2 

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  • Peripheral mechanisms of mechanically evoked swallows Invited

    Takanori Tsujimura, Makoto Inoue

    The 97th Annual Meeting of the Physiological Society of Japan  2020.3 

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Awards

  • The 1st International Conference of Asian Dysphagia Society Travel Award (Oral Presentation)

    2023.11   Asian Dysphagia Society   Role of P2X receptor on the initiation of swallows in anesthetized rats

    Takanori Tsujimura

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  • Scientific Abstract Oral Presentation

    2023.3   31st Dysphagia Research Society Annual Meeting   NMDA and non-NMDA glutamate receptors in the rostral-commissural, medial, and ventrolateral nTS subnuclei are involved in the initiation of swallows in anesthetized guinea pigs

    Takanori Tsujimura

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  • 第18回日本咳嗽研究会優秀演題賞

    2016.10   日本咳嗽研究会   食道への酸持続投与がもたらす嚥下誘発減弱

    辻村 恭憲

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  • 歯科基礎医学会賞賞

    2010.9   歯科基礎医学会   嚥下反射調節におけるラット脳幹ニューロンERKリン酸化の関与

    辻村 恭憲

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  • The IADR Neuroscience Wiley-Blackwell Publishing Young Investigator Research Award

    2010.7   IADR Neuroscience Group   Involvement of NTS nociceptive neurons in an inhibition of swallows

    辻村 恭憲

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  • 第30回日本疼痛学会優秀演題

    2008.7   日本疼痛学会優秀演題   ラット孤束核および三叉神経傍核ニューロンにおけるERKリン酸化は嚥下反射抑制に関与する

    辻村 恭憲

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Research Projects

  • 温度刺激が咀嚼機能と嚥下機能に与える効果とそのメカニズムの解明

    Grant number:2025A0011

    2025.4 - 2028.3

    Research category:ロッテ財団 第12回 「奨励研究助成」

    Awarding organization:公益財団法人ロッテ財団

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    Authorship:Principal investigator 

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  • Attempt to form the basis of anatomical diagnostic protocol for dysphagia

    Grant number:23K18356

    2023.6 - 2026.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Challenging Research (Exploratory)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\6370000 ( Direct Cost: \4900000 、 Indirect Cost:\1470000 )

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  • 摂食機能と呼吸機能の関連メカニズムの解明

    Grant number:20KK0353

    2021.4 - 2024.3

    System name:科学研究費助成事業

    Research category:国際共同研究加速基金(国際共同研究強化(A))

    Awarding organization:日本学術振興会

    辻村 恭憲

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    Grant amount:\14170000 ( Direct Cost: \10900000 、 Indirect Cost:\3270000 )

    本研究は咀嚼・嚥下・呼吸・咳嗽の機能連関および嚥下誘発メカニズムの解明を目的としている.本年度は舌の機械刺激による水誘発嚥下の変調効果ならびに嚥下中枢として知られている孤束核の細胞外神経活動の変調効果を検証した.最初に咽喉頭領域への水刺激により誘発される嚥下に関与する感覚神経の同定を行った.両側上喉頭神経切断時には,水刺激による嚥下はほぼ消失されたことから,水誘発嚥下には上喉頭神経が重要な役割を果たしていると考えられた.また,水誘発嚥下回数は,舌へのピンチ刺激(侵害刺激)で有意に少なくなったが,圧刺激(非侵害刺激)では変化しなかった.過去の研究成果から,三叉神経領域へのカプサイシンによる侵害刺激が,孤束核のGABA作動性神経細胞の活性化を高め,孤束核レベルで嚥下を抑制する可能性が示されている.そこで,孤束核神経細胞から細胞外神経活動を記録し,舌へのピンチ刺激による変調効果を検証した.上喉頭神経刺激に応答する孤束核神経細胞応答を記録したところ,同定された孤束核神経細胞の多くが,同側の上喉頭神経刺激に単シナプス性の応答を示し,少数だけが多シナプス性の応答を示していた.単シナプス性および多シナプス性に応答した孤束核神経細胞には,舌へのピンチ刺激により応答潜時が延長するものが確認された.以上の結果から,舌への機械的侵害刺激は孤束核の嚥下関連神経細胞応答を変調させ,嚥下誘発を抑制している可能性が考えられた.

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  • “よく噛むこと”がもたらす嚥下機能の変調効果

    2020.12 - 2022.11

    System name:2020年度 やずや食と健康助成研究 キャリアアップ部門

    辻村 恭憲, 井上 誠

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  • Effect of chewing task on dysphagia

    Grant number:20K10069

    2020.4 - 2023.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

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  • 機械刺激誘発嚥下メカニズムの解明

    2017.10 - 2019.3

    System name:2017年GSKジャパン研究助成

    Awarding organization:グラクソ・スミスクライン

    辻村 恭憲

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    Authorship:Principal investigator  Grant type:Competitive

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  • Role of paratrigeminal nucleus connected to mouth and pharynx on chewing and swallowing functions

    Grant number:17K11775

    2017.4 - 2020.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Tsujimura Takanori

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    The aim of this study was to investigate the role of paratrigeminal nucleus (Pa5) on chewing and swallowing functions. The swallowing reflexes evoked by electrical stimulation of superior laryngeal nerve (SLN) was inhibited during electrical stimulation of Pa5. We did not evoke any swallows by the focal microinjection of glutamate receptor agonists and GABAA receptor antagonist into the Pa5. On the other hand, many swallows were evoked following the microinjection of glutamate receptor agonists and GABAA receptor antagonist into the nucleus tractus solitarii. The SLN is a primary carrier of initiation of swallowing evoked by laryngeal mechanical stimulation. Furthermore, epithelial sodium channel is involved in those swallows.

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  • カプサイシンによる嚥下機能改善メカニズムの解明

    2016.10 - 2017.9

    System name:山崎香辛料振興財団平成28年度助成金

    Awarding organization:山崎香辛料振興財団

    辻村 恭憲

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  • Effect of functional impairment of tongue on swallowing

    Grant number:26870207

    2014.4 - 2017.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Young Scientists (B)

    Awarding organization:Japan Society for the Promotion of Science

    TSUJIMURA Takanori

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    The aim of this study was to investigate the role of the hypoglossal nerve on swallowing movement. We measured swallowing pressure at the oropharynx (OP), upper esophageal sphincter (UES), and cervical esophagus (CE) in anesthetized rats. A swallow was evoked by mechanical stimulation to the larynx. The swallow was identified by activation of the suprahyoid and thyrohyoid muscles. Following bilateral hypoglossal nerve transection (Bi-12Nx), the oropharyngeal pressure during swallowing was significantly decreased than that before transection. The oropharyngeal pressure during swallowing following Bi-12Nx was significantly increased by covering the hard and soft palates with dental material. These results suggest that the hypoglossal nerve play a crucial role in the generation of oropharyngeal pressure during swallowing, and that covering the palates with dental material may reverse the impared swallowing function after damage of hypoglossal nerves.

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  • Inhibition of swallowing during chewing

    Grant number:23792507

    2011.4 - 2012

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Young Scientists (B)

    Awarding organization:Japan Society for the Promotion of Science

    TSUJIMURA Takanori

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    To clarify the neural mechanism of swallowing inhibition during chewing, we investigated the effect of electrical stimulation of two cortical masticatory areas (A- and P-area) on superior laryngeal nerve-evoked swallows. The number of evoked swallows was significantly lower during A-area stimulation. Conversely, swallowing reflexes were not changed by P-area stimulation. The inhibition of swallows by A-area stimulation was notaffected by an increase in sensory input facilitated by wooden stick application between upper and lower teeth, or A-area stimulation preceding SLN stimulation. We speculate that swallowing inhibition may be mediated by direct inputs from the A-are or inputs via the masticatory center into the swallowing center.

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  • The elucidation of the role of the insular cortex in relation to oral functions

    Grant number:24K13002

    2024.4 - 2027.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

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  • Neurophysiological analysis of oral function improvement using diffusion tensor imaging

    Grant number:23K09291

    2023.4 - 2026.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

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  • Multiple approach to evaluate dysphagia condition using animal model

    Grant number:22KK0139

    2022.10 - 2025.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\20150000 ( Direct Cost: \15500000 、 Indirect Cost:\4650000 )

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  • Functional role of anteiror cingulate cortex on feeding

    Grant number:22K19616

    2022.6 - 2025.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Challenging Research (Exploratory)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

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  • Impact of orofacial function on recovery from dysphagia caused by cerebrovascular disorders

    Grant number:21H03128

    2021.4 - 2024.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\17290000 ( Direct Cost: \13300000 、 Indirect Cost:\3990000 )

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  • Researching for a dysphagia using pathological animal model

    Grant number:19K10201

    2019.4 - 2022.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Shiraishi Naru

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    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    We succeeded in recording the muscle activities involved in mastication and swallowing from an unrestrained rat. It was possible to identify the timing of swallowing from the muscle activity record and its sound.
    Analysis was performed using the created model, and although there were no individual differences in the parameter for mastication, it was suggested that there was a difference in the swallowing parameters (ex thyrohyoid muscle activity). The effect of ligation of the external carotid artery, which is the feeding artery in the maxillofacial region, was not observed electromyographically in a short period after ligation.

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  • Functional interaction of neural mechanism between chew and swallow

    Grant number:16H05522

    2016.4 - 2019.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    Inoue Makoto

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    Grant amount:\17030000 ( Direct Cost: \13100000 、 Indirect Cost:\3930000 )

    We found that continuous pharyngeal electrical stimulation induces long-term facilitation on the swallow related cortical neural network in humans. In addition, chewing behaviors differ among several chewing tasks in that voluntary chewing changes the oral transport in a process of bolus formation and increases pharyngeal swallowing duration, which suggests that difference in individual chewing performance does not affect chewing duration in a certain range of bolus condition but depends on the saliva flow. In animal studies, we demonstrated that jaw opening reflex responses are inhibited during swallow, and modulation of neural excitability may occur in the brainstem. We also found that mechanical, carbonated water and proton evoked swallow are induced by activation of epithelial sodium channel (ENaC), acid sensing ion channel 3 (ASIC3) and transient receptor potential vaniloid 1 (TRPV1), respectively.

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  • Development of a rat model for studying the behavioral assessment of dysphagia

    Grant number:16K11589

    2016.4 - 2019.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Naru Shiraishi

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    We have optimized tooth extraction and implant procedures and established protocols for high-speed biplanar videofluoroscopy (XROMM) imaging and analysis of mandible and tongue markers to permit objective assessment of feeding kinematics over time in freely behaving rats before and after dental manipulations. Rats were chronically implanted with radiopaque beads into the skull, mandible, and tongue to characterize kinematics of feeding behaviors using XROMM. In addition, We have successfully developed a series of surgical procedures and the protocol to obtain the natural feeding behavior in rats. The bipolar polyurethane-coated stainless steel wire electrodes were placed in the bilateral masseter, right suprahyoid and right thyrohyoid muscles for electromyogram (EMG) recording.
    These protocols are extremely meaningful to assess the behavioral changes of jaw and tongue kinematics , and to analyze the effects on mastication and swallowing during natural feeding and for dysphagia.

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  • Assessment for peripheral and central controls of ingestion behavior

    Grant number:25670814

    2013.4 - 2016.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Challenging Exploratory Research

    Awarding organization:Japan Society for the Promotion of Science

    Makoto Inoue, TSUJIMURA Takanori, MAGARA Jin

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    Grant amount:\3770000 ( Direct Cost: \2900000 、 Indirect Cost:\870000 )

    We investigated how peripheral inputs might assist central inputs in the control of voluntary evoked swallowing and whether natural chewing behavior affects the initiation of involuntary swallowing in healthy humans. We delivered pharyngeal electrical stimulation (PES) to the laryngopharynx and compared the number of swallows that occurred with and without PES during chewing, voluntary swallowing or at rest. PES significantly increased the number of voluntary evoked swallows at rest and during voluntary swallowing and this facilitatory effect was larger at rest than during chewing. Based on the current results, we suggest that (1) peripheral inputs within a certain range appear to facilitate the central inputs that control voluntary swallowing, (2) inter-individual variations in swallowing initiation may arise from differences in the excitability of the common neural network, (3) during chewing, such that the neural network associated with chewing may regulate swallowing initiation.

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  • Central and peripheral control of ingestion function

    Grant number:24390431

    2012.4 - 2015.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    INOUE Makoto, HORI Kazuhiro, TANIGUCHI Hiroshige, TSUJIMURA Takanori, NAKAMURA Yuki, MAGARA Jin

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    Grant amount:\18070000 ( Direct Cost: \13900000 、 Indirect Cost:\4170000 )

    From human and animal studies, we successfully clarified the followings. 1) Initiation of reflex swallowing is not affected by oral inputs but by chewing behavior or activation of chewing central pattern generator. 2) Motor pattern of swallowing is not affected by conditioning stimulation such as peripheral stimulation. 3) Because there is a positive correlation between effect of central inputs and peripheral inputs on the initiation of swallow, inter-individual variation of initiation of swallow is dependent on the excitability of neural activity in the lower brain stem. 4) repetitive pharyngeal stimulation shortly inhibits the excitability involved in the swallowing center but facilitates that involved in voluntary swallow in the long term.

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  • Neuronal control of swallowing center on the trigeminal activity

    Grant number:23659982

    2011.4 - 2013.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Challenging Exploratory Research

    Awarding organization:Japan Society for the Promotion of Science

    INOUE Makoto, TSUJIMURA Takanori

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    Grant amount:\3640000 ( Direct Cost: \2800000 、 Indirect Cost:\840000 )

    The aim of this study was to examine the neuronal control of swallowing center on thetrigeminal neuronal activity and to clarify coordination of orofacial muscles in animals. Unit discharges were recorded from digastric and mylohyoid motoneurons and the patterns of them during swallowing were different. Moreover, trigeminal neuronal activity during swallowing was evaluated by measurement of jaw opening reflex. Not only chewing but also swallowing strongly inhibited the jaw opening reflex responses, suggesting that these behaviors or central neuronal network for chewing and swallowing may regulate the excitability of trigeminal neurons.

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Teaching Experience

  • 臨床課題解決基礎演習

    2024
    Institution name:新潟大学

  • 摂食リハ関係コースワークIB

    2022
    -
    2023
    Institution name:新潟大学

  • 摂食リハ関係コースワークIIB

    2022
    -
    2023
    Institution name:新潟大学

  • 摂食・嚥下障害診断学演習IIB

    2021
    Institution name:新潟大学

  • 臨床歯学コースワーク(摂食リハ関係コースワークI)

    2021
    Institution name:新潟大学

  • 基礎・臨床連続講義II(摂食・嚥下機能評価学)

    2021
    Institution name:新潟大学

  • 摂食・嚥下障害診断学演習IB

    2021
    Institution name:新潟大学

  • 臨床歯学コースワーク(摂食リハ関係コースワークII)

    2021
    Institution name:新潟大学

  • 摂食・嚥下障害診断学演習IIA

    2021
    Institution name:新潟大学

  • 摂食・嚥下障害診断学演習IA

    2021
    Institution name:新潟大学

  • 歯学研究演習

    2021
    Institution name:新潟大学

  • 摂食嚥下障害学

    2020
    Institution name:新潟大学

  • 加齢歯科学

    2020
    Institution name:新潟大学

  • 口腔と全身との関わり

    2020
    Institution name:新潟大学

  • 地域歯科保健実習

    2017
    Institution name:新潟大学

  • 摂食・嚥下障害診断学演習ⅡA

    2017
    -
    2018
    Institution name:新潟大学

  • 摂食・嚥下障害診断学演習ⅡB

    2017
    Institution name:新潟大学

  • 摂食・嚥下障害診断学演習ⅠA

    2017
    Institution name:新潟大学

  • 摂食・嚥下障害診断学演習ⅠB

    2017
    Institution name:新潟大学

  • チーム医療実践論

    2016
    -
    2023
    Institution name:新潟大学

  • 臨床予備実習

    2016
    -
    2017
    Institution name:新潟大学

  • 高齢者・障害者歯科学

    2015
    Institution name:新潟大学

  • 加齢歯科学Ⅱ

    2015
    -
    2018
    Institution name:新潟大学

  • 加齢歯科学Ⅰ

    2015
    -
    2018
    Institution name:新潟大学

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