Updated on 2024/05/04

写真a

 
HAYASAKI Haruaki
 
Organization
Academic Assembly Institute of Medicine and Dentistry SHIGAKU KEIRETU Professor
Graduate School of Medical and Dental Sciences Professor
Faculty of Dentistry Department of Dentistry Professor
Title
Professor
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Degree

  • 博士(歯学) ( 1992.9   九州大学 )

Research Interests

  • Dentistry for Special Needs

  • Oral Health

  • Craniofacial Function

  • pediatric dentistry

  • 摂食機能

Research Areas

  • Life Science / Developmental dentistry  / pediatric dentistry

Research History (researchmap)

  • Niigata University Graduate School of Medical and Dental Sciences   Division of Pediatric Dentistry   Professor

    2010.4

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  • Kagoshima University Graduate School of Medical and Dental Sciences   Department of Pediatric Dentistry   Associate Professor

    2008.4 - 2010.3

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  • Kyushu University Faculty of Dental Science   Department of Pediatric Dentistry   Lecturer

    2003.4 - 2008.3

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  • Department of Orthodontics,   Baylor College of Dentistry, Texas A & M University System,   Adjunct Assistant Professor

    1997.10 - 1999.3

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  • Kyushu University   Research Assistant

    1991.4 - 2003.3

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Research History

  • Niigata University   Faculty of Dentistry School of Dentistry   Professor

    2010.4

  • Niigata University   Graduate School of Medical and Dental Sciences   Professor

    2010.4

Education

  • Kyushu University Faculty of Dental Science   Ph.D

    1987.4 - 1991.3

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    Country: Japan

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  • Kyushu University   Faculty of Dentistry   School of Dentistry

    - 1987.3

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    Country: Japan

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Professional Memberships

  • JAPANESE DENTAL EDUCATION ASSOCIATION

    2021.3

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  • JAPANESE ASSOCIATION FOR ORAL BIOLOGY

    2021.3

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  • JAPANESE SOCIETY FOR ORAL HEALTH

    2020.3

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  • THE JAPANESE SOCIETY FOR DISABILITY AND ORAL HEALTH

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  • THE JAPANESE SOCIETY OF PEDIATRIC DENTISTRY

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  • NIIGATA DENTAL SOCIETY

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  • Japanese Society of Stomatognathic Function

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Committee Memberships

  • 文部科学省   大学設置・学校法人審議会 歯学専門委員  

    2017.11 - 2018.10   

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    Committee type:Government

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  • 日本歯科医学会   重点研究委員会  

    2017.4 - 2019.4   

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    Committee type:Academic society

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  • 厚生労働省   歯科医師国家試験委員  

    2014.4 - 2017.3   

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    Committee type:Government

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  • 日本障害者歯科学会   評議員  

    2014.1   

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    Committee type:Academic society

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  • 日本小児歯科学会   理事  

    2010.4   

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    Committee type:Academic society

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  • 日本顎口腔機能学会   評議員  

    2010.4   

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    Committee type:Academic society

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Qualification acquired

  • 日本小児歯科学会 専門医

  • 日本小児歯科学会 指導医

  • 日本障害者歯科学会 認定医

  • 日本障害者歯科学会 指導医

  • Dentist

 

Papers

  • Evaluation of oral function using a composite sensor during maximum lip closure and swallowing in normal children and adults. International journal

    Mio Hozawa, Yuki Nakamura, Tetsuya Sotome, Tsutomu Nakajima, Mika Hanasaki, Yuki Sasakawa, Saeko Tsukuno, Yuki Yonemoto, Haruaki Hayasaki

    Journal of oral rehabilitation   2024.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: There is growing interest in the development of objective methods for assessing lip-closing function in children. OBJECTIVE: To obtain normative data for healthy children in the developmental stages of lip closure function, we quantitatively evaluated oral movements associated with lip closure in children and adults using a composite sensor (CS). METHODS: Twenty-five normal children (11 boys, 14 girls) aged 8.8 ± 1.6 years and 25 young adults (13 men, 12 women) aged 27.4 ± 3.9 years were asked to perform test movements, maximal lip closure and swallowing of 3 mL of water. Lip-closing pressure (LP), intraoral baro-pressure (IP) and electromyographic (EMG) activity of the upper orbicularis oris muscle were simultaneously recorded using the CS. RESULTS: EMG activity of the upper orbicularis oris muscle during closure was significantly greater in adults than in children. There were significant positive correlations between integral values of LP and EMG for closure in adults (r = .527, p = .008) but not in children, and significant positive correlations between integral values of LP and IP for swallowing in children (r = .508, p = .010) but not in adults. CONCLUSIONS: The CS may provide an effective tool for evaluating lip function in children acquiring oral function. For the combination of maxillary orbicularis oculus contraction and formation of intraoral negative pressure, EMG activity of the upper orbicularis oris muscle involvement in LP and IP involvement in LP may differ between children and adults.

    DOI: 10.1111/joor.13705

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  • 定期的歯科介入が行われている施設利用知的障害者の支援必要度と口腔保健支援状況との関連性

    吉田 歩未, 中村 由紀, 大島 邦子, 中島 努, 笹川 祐輝, 濃野 要, 早崎 治明

    口腔衛生学会雑誌   73 ( 4 )   260 - 269   2023.10

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    Language:Japanese   Publisher:(一社)日本口腔衛生学会  

    本研究は,知的障害者の障害支援区分をはじめとした支援の必要度と口腔内の状態および口腔ケアを受ける際の協力度(口腔ケア協力度)との関連性を明らかにすることを目的とした.調査対象は新潟県内の入所型の障害者支援施設の知的障害のある施設利用者101名とした.結果として,障害支援区分と歯の状態では現在歯数,健全歯数,処置歯数,未処置歯数,喪失歯数において有意差を認めなかった.一方,障害支援区分と口腔ケア協力度では有意差を認め,区分が高くなると口腔ケア協力度が有意に低下した.また,ADL評価でも障害支援区分と同様の結果を認めた.ADL自立度「要支援」において口腔ケア協力度は起き上がり,立ち上がり,衣服の着脱,危険の認識,入浴,食事の6項目が協力度「悪い」が有意に高く,ADL自立度「自立」において衣服の着脱,危険の認識,入浴,排尿,食事の5項目が協力度「良い」が有意に高かった.これらの結果から,定期的な歯科介入が実施されている施設の知的障害者の歯の状態は障害支援区分に関連しにくく,支援の必要度が高いほど口腔保健支援に対する協力が得づらいことが示唆された.またADL評価の結果より,支援全般における必要度から口腔ケア協力度を評価する際には,障害支援区分の認定調査項目「身の回りの世話や日常生活等に関連する項目」といった,知的能力を必要とする動作の自立度がスクリーニングに有効である可能性が示唆された.(著者抄録)

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    Other Link: https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J00440&link_issn=&doc_id=20231214240001&doc_link_id=10.5834%2Fjdh.73.4_260&url=https%3A%2F%2Fdoi.org%2F10.5834%2Fjdh.73.4_260&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • 小児と成人の捕食は異なる スプーンと頭部の協調

    腰越 佐和子, 中島 努, 花崎 美華, 中村 由紀, 五月女 哲也, 米本 裕貴, 笹川 祐輝, 朴沢 美生, 築野 沙絵子, 早崎 治明

    小児歯科学雑誌   61 ( 大会抄録号 )   117 - 117   2023.4

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  • 摂食先行期に関する研究 小児と成人における食具操作と開口動作

    中島 努, 米本 裕貴, 花崎 美華, 五月女 哲也, 中村 由紀, 笹川 祐輝, 朴沢 美生, 築野 沙絵子, 早崎 治明

    小児歯科学雑誌   61 ( 大会抄録号 )   122 - 122   2023.4

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  • 複合センサーを用いた嚥下時の小児口唇閉鎖機能の評価

    中村 由紀, 朴沢 美生, 五月女 哲也, 中島 勉, 花崎 美華, 笹川 祐輝, 築野 沙絵子, 米本 裕貴, 早崎 治明

    小児歯科学雑誌   61 ( 大会抄録号 )   149 - 149   2023.4

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  • 一時保護所に保護中の被虐待児童の歯種別う蝕罹患状況に関する報告

    野上 有紀子, 中村 由紀, 五月女 哲也, 清川 裕貴, 朴沢 美生, 築野 沙絵子, 笹川 祐輝, 鈴木 絢子, 花崎 美華, 中島 努, 大島 邦子, 齊藤 一誠, 岩瀬 陽子, 早崎 治明

    障害者歯科   44 ( 1 )   10 - 18   2023.2

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    被虐待児童はう蝕が多いとされているが,これまでの報告の多くは,う蝕有病者率やう蝕経験歯数に限られていた.本研究では,被虐待児童におけるう蝕罹患状況の特徴を探索するため,歯種別に解析を行った.歯種別解析の対象は,2~19歳の一時保護所への入所理由が「虐待」の児童(虐待群)323名とした.年齢に応じて,乳歯の解析では2区分(2~5歳,6~9歳),永久歯では3区分(5~9歳,10~14歳,15~19歳)とし,歯科疾患実態調査(対照群)と比較を行った.乳歯,永久歯ともに一人平均未処置歯数は虐待群において有意に高く,永久歯においては一人平均う歯数がすべての年齢区分で虐待群が有意に高かった.歯種別に解析した結果,乳歯では上顎左側乳中切歯と上顎右側乳犬歯,永久歯では第一大臼歯と第二大臼歯において,虐待群が有意にう歯保有者率が高かったが,虐待群の歯種別う蝕罹患状況として明確な特徴と判断できるものはなく,一般にう蝕が発生しやすい部位において虐待群ではさらに高い割合でう蝕を有し,永久歯萠出直後早い段階で罹患していると考えられた.一人平均う歯数のパーセンタイル値では,いずれの年齢区分においても虐待群の25%は対照群と同様にう歯を有していなかった一方で,虐待群の一部の者のう歯数が非常に多く,虐待群の全体的なう蝕歯数の数値を引き上げていると推察された.(著者抄録)

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    Other Link: https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J02489&link_issn=&doc_id=20230403180002&doc_link_id=10.14958%2Fjjsdh.44.10&url=https%3A%2F%2Fdoi.org%2F10.14958%2Fjjsdh.44.10&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • 茶碗の中における食具の動きは異なる

    米本 裕貴, 中島 努, 中村 由紀, 花崎 美華, 笹川 祐輝, 五月女 哲也, 築野 沙絵子, 朴沢 美生, 早崎 治明

    小児歯科学雑誌   61 ( 地方会抄録号 )   10 - 10   2023.2

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  • 摂食運動先行期に関する研究 食具と手

    中島 努, 花崎 美華, 中村 由紀, 五月女 哲也, 米本 裕貴, 笹川 祐輝, 築野 沙絵子, 朴沢 美生, 吉田 歩未, 早崎 治明

    小児歯科学雑誌   61 ( 地方会抄録号 )   29 - 29   2023.2

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  • 摂食運動先行期に関する研究 食具の入出

    花崎 美華, 中島 努, 中村 由紀, 五月女 哲也, 米本 裕貴, 笹川 祐輝, 築野 沙絵子, 朴沢 美生, 吉田 歩未, 早崎 治明

    小児歯科学雑誌   61 ( 地方会抄録号 )   29 - 29   2023.2

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  • 食品やその摂取方法の違いによる捕食時呼吸運動の変化

    築野 沙絵子, 中村 由紀, 中島 努, 花崎 美華, 笹川 祐輝, 朴沢 美生, 五月女 哲也, 米本 裕貴, 早崎 治明

    新潟歯学会雑誌   52 ( 2 )   100 - 100   2022.12

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  • 食具の違いに着目した捕食動作の三次元動作解析

    五月女 哲也, 中島 努, 中村 由紀, 花崎 美華, 笹川 祐輝, 築野 沙絵子, 朴沢 美生, 米本 裕貴, 早崎 治明

    新潟歯学会雑誌   52 ( 2 )   100 - 101   2022.12

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  • 乳歯歯髄細胞由来iPS細胞からの人工的膵幹細胞の樹立

    清川 裕貴, 中村 由紀, 大島 邦子, 早崎 治明, 齊藤 一誠

    新潟歯学会雑誌   52 ( 2 )   95 - 95   2022.12

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  • 知的障害者福祉施設における支援者の口腔保健支援の負担感に関する調査

    吉田 歩未, 中村 由紀, 大島 邦子, 中島 努, 笹川 祐輝, 早崎 治明

    日本障害者歯科学会総会および学術大会プログラム・抄録集   39回   196 - 196   2022.10

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  • 長期的口腔管理を行った遺伝性感覚・自律神経ニューロパチー(HSAN)5型患者の一例

    大島 邦子, 坂本 裕里子, 筒井 亜香里, 近藤 淳子, 早崎 治明

    日本障害者歯科学会総会および学術大会プログラム・抄録集   39回   149 - 149   2022.10

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  • 複合センサーで評価する小児口腔機能の特徴

    朴沢 美生, 中村 由紀, 中島 努, 花崎 美華, 笹川 祐輝, 築野 沙絵子, 五月女 哲也, 早崎 治明

    新潟歯学会雑誌   52 ( 1 )   37 - 37   2022.6

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  • 知的障害者福祉施設における障害支援区分に基づく口腔保健支援システムに向けた検討 障害支援区分と口腔保健支援および歯科疾患実態との関連性

    吉田 歩未, 中村 由紀, 中島 努, 笹川 祐輝, 大島 邦子, 早崎 治明

    新潟歯学会雑誌   52 ( 1 )   38 - 39   2022.6

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  • 糖尿病患児由来乳歯歯髄細胞を用いた膵臓特異的幹細胞(T1D-iTSC-P)の樹立

    清川 裕貴, 稲田 絵美, 井葉野 夏実, 安村 真一, 岡野 哲, 岩瀬 陽子, 早崎 治明, 齊藤 一誠

    小児歯科学雑誌   60 ( 大会抄録号 )   224 - 224   2022.3

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  • スプーンを用いた捕食における口腔と上肢の協調運動の発達変化

    笹川 祐輝, 中村 由紀, 中島 努, 花崎 美華, 築野 沙絵子, 朴沢 美生, 五月女 哲也, 齊藤 一誠, 早崎 治明

    小児歯科学雑誌   60 ( 大会抄録号 )   137 - 137   2022.3

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  • 幼児期における舌小帯異常の実態調査

    近藤 亜子, 岡野 哲, 津金 裕子, 飯沼 光生, 犬塚 勝昭, 土岐 志麻, 石通 宏行, 岡 暁子, 倉重 圭史, 桑原 康生, 佐野 正之, 鈴木 淳司, 田中 晃伸, 仲野 和彦, 中村 由紀, 早崎 治明, 星野 倫範, 齊藤 正人, 木本 茂成, 牧 憲司, 日本小児歯科学会臨床研究推進委員会

    小児歯科学雑誌   59 ( 3 )   107 - 116   2021.11

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    わが国における舌小帯異常の発生頻度は、報告によって大きな開きがある。そこで、発現頻度、年齢間の比較、形態的異常と機能的問題との相関について検討することを目的として、全国的に4〜6歳の小児2,886名を対象として実態調査を行い、以下の結果を得た。1. 舌小帯は、長さが1cm未満および舌尖部の形態がハート型になる小児の割合が約10%であり、2mm以上肥厚している割合は約3%、中程度(1〜2mm)は約25%であった。また、年齢間で差は認められなかった。2. 舌の前方、側方および垂直運動で問題が認められた小児は、形態的な異常と同程度で、ポッピングや構音の不明瞭者は約30%であった。また、機能的項目については、年齢間で相関が認められ、年齢が増すごとに舌の可動域が大きくなり、指示通りに動かすことができた。3. 舌小帯の形態と機能との間には相関が認められ、長さや舌尖の形態は前方、側方および垂直運動での機能的な問題と関連が強かった。4. 下顎の正中離開や咬合関係は、舌小帯の形態的および機能的な問題との関連性は非常に弱かった。(著者抄録)

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  • The effects of reducing the root length by apicoectomy on dental pulp revascularization following tooth replantation in mice. International journal

    Kuniko Nakakura-Ohshima, Angela Quispe-Salcedo, Hiroto Sano, Haruaki Hayasaki, Hayato Ohshima

    Dental traumatology : official publication of International Association for Dental Traumatology   37 ( 5 )   677 - 690   2021.10

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    BACKGROUND/AIM: Root length is a critical factor for dental pulp regeneration following tooth replantation. The aim of this study was to analyze the effects of reducing the root length by apicoectomy on the pulp healing process using a model for tooth replantation. MATERIAL AND METHODS: After extraction of the upper first molars (M1) of 3-week-old mice, the roots from the experimental group (EG) were shortened to half to two-thirds of their length before replantation, whereas in the control group (CG) the extracted teeth were immediately repositioned into their alveolar sockets. To determine the effects of root resection on the survival of inherent pulp cells, this study included tooth transplantation with root resection using wild-type (WT) and green fluorescent protein (GFP) transgenic mice. The M1 of GFP transgenic mice were transplanted into the alveolar socket of the M1 of WT mice. The roots of the right M1 were shortened (EG), whereas the left M1 remained untreated (CG). RESULTS: Apoptotic cells in the EG significantly decreased in number compared with the CG at day 3. Cell proliferative activity in the EG was significantly higher than that in the CG in the root pulp during days 3-5, and nestin-positive odontoblast-like cells began to arrange themselves along the pulp-dentin border in the cusp area at day 5 in the EG but not in the CG. At week 2, tertiary dentin had formed throughout the pulp in the EG, whereas the combined tissue of dentin and bone occupied the pulp space in 60% of the CG. Root resection also positively affected the survival of inherent pulp cells to differentiate into odontoblast-like cells as demonstrated by transplantation using GFP transgenic mice. CONCLUSIONS: Reducing the root length accelerated pulp regeneration following tooth replantation due to the better environment for revascularization.

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  • Oral Function and Feeding Management in a Child with Alpha Thalassemia X-Linked Intellectual Disability Syndrome. International journal

    Yuki Nakamura, Mika Hanasaki, Tetsufumi Sano, Haruaki Hayasaki, Yoko Iwase, Issei Saitoh

    Journal of dentistry for children (Chicago, Ill.)   88 ( 3 )   206 - 209   2021.9

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    Alpha-thalassemia X-linked intellectual disability (ATR-X) syndrome affects males and is associated with profound developmental delay, facial dysmorphism, genital abnormalities, and alpha thalassemia. Appropriate oral health management for affected patients is important. The purposes of this report are to describe a case involving six years of oral health management, including training in eating, drinking and swallowing, for a patient with ATR-X syndrome, and to discuss the morphological and functional oral characteristics of this disorder. The patient's oral dysfunctions were incompetent lip-closing, inappropriate tongue protrusion, deviation of chewing acquisition, and incompetent oral and pharyngeal bolus propulsion. Other problems included inappropriate ingestion posture, low interest in meals, and poor oral hygiene. A stable oral intake and an improved eating posture were achieved through an intervention; however, the patient's inappropriate tongue protrusion, deviation of chewing acquisition, and incompetent bolus propulsion remained unchanged.

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  • Lip-closing strength in children is enhanced by lip and facial muscle training. International journal

    Yukiko Nogami, Issei Saitoh, Emi Inada, Daisuke Murakami, Yoko Iwase, Naoko Kubota, Yuki Nakamura, Kuniko Nakakura-Ohshima, Ayako Suzuki, Youichi Yamasaki, Haruaki Hayasaki, Yasutaka Kaihara

    Clinical and experimental dental research   8 ( 1 )   209 - 216   2021.9

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    OBJECTIVES: Weakening of lip-closing strength (LCS) associated with an incompetent lip seal (ILS) may affect the oral balance between the lip and tongue pressures. The purpose of this study was to evaluate the effects of lip-closing training in children with lower LCS and/or abnormal habits across different age groups and to compare its effects on increasing LCS in children with malocclusion and/or oral habits. MATERIAL AND METHODS: Lip-closing training was performed by 154 Japanese children aged 3-12 years using a specialized training device at home for 3 months. Children with oral habits and/or exhibiting less than standard LCS were included. LCS was measured using a digital strain force gauge at a dental clinic at the beginning (T0) and after each month (after 3 months: T3). RESULTS: Children had higher LCS responses after lip-closing training. The first month of lip-closing training was more effective than the subsequent months. With lip-closing training, the LCS increased from an average of 6.2 N (T0) to 11.4 N (T3) in Group I, 7.9 N (T0) to 12.8 N (T3) in Group II, and 6.8 N to 11.4 N in Group III. Anterior cross bite, including reverse bite, open bite, and tongue thrusting, significantly reduced training effects. CONCLUSION: Our findings showed that lower LCS in children with ILS resulted in greater responses to lip-closing training in a short period, but oral dysfunction, such as abnormal habits, inhibited the positive effects of training. Our results suggest that less detrimental effects of malocclusion and abnormal oral habits lip-closing training enhances LCS in younger children.

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  • Lip-closing pressure during food intake from a spoon in normal children. International journal

    Yuki Sasakawa, Yuki Nakamura, Issei Saitoh, Tsutomu Nakajima, Saeko Tsukuno, Mio Hozawa, Tetsuya Sotome, Yukiko Nogami, Mie Kurosawa, Yoko Iwase, Toyohiko Hayashi, Haruaki Hayasaki

    Journal of oral rehabilitation   48 ( 6 )   711 - 719   2021.6

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    BACKGROUND: Understanding the refinement of self-feeding skills is useful for the assessment of oral functional development in children. OBJECTIVES: To determine normative data on lip closing during food intake in the development of independent spoon-feeding in normal children, we tested the hypothesis that lip-closing pressure and spoon operation differ depending on food type. METHODS: Fifteen normal children (eight boys, seven girls; mean age: 6.5 years) were asked to eat test foods (2, 3 and 5 g of yogurt and cream cheese) freely with a spoon. Lip-closing pressures and kinematic data on spoon operation were recorded simultaneously with a strain gauge transducer embedded in the spoon and Vicon motion analysis, respectively. RESULTS: In the most common lip-pressure pattern, only positive pressure was generated. In the second most common pattern, negative pressure occurred first, followed by positive pressure; this pattern was seen infrequently. Positive pressure (P < .001), pressure duration (P < .001) and spoon intra-oral time (P < .05) during intake of cream cheese (an adhesive food) were significantly greater than those during intake of yogurt (a non-adhesive food). Pressure onset occurred at the beginning of the spoon withdrawal period or at the turning point from spoon insertion to withdrawal, depending on the food. CONCLUSIONS: Lip-closing force and spoon operation varied depending on food type in preschool and early elementary school children. Our findings suggest the need to consider the importance of food diversity and to pay attention to the spoon withdrawal period when assessing the development and maturation of lip function.

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  • Prevalence of an incompetent lip seal during growth periods throughout Japan: a large-scale, survey-based, cross-sectional study. International journal

    Yukiko Nogami, Issei Saitoh, Emi Inada, Daisuke Murakami, Yoko Iwase, Naoko Kubota, Yuki Nakamura, Masami Kimi, Haruaki Hayasaki, Youichi Yamasaki, Yasutaka Kaihara

    Environmental health and preventive medicine   26 ( 1 )   11 - 11   2021.1

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    BACKGROUND: Systemic and local factors may lead to disruption of craniofacial growth and development, causing an imbalance between the orofacial skeleton, muscle and soft tissue, dental occlusion, and the dental arch during growth periods. We aimed to reveal whether the prevalence of incompetent lip seal (ILS) varies with age and region, as well as to clarify the factors related to an ILS, in a national, large-scale epidemiological study. METHODS: We surveyed 3399 children, from 3 to 12 years of age, visiting 66 pediatric dental clinics throughout Japan. For this survey, we employed a questionnaire consisting of 44 questions regarding daily health conditions and lifestyle habits. We evaluated the differences in ILS prevalence by age and region (using a Cochran-Armitage test for trend and a Kruskal-Wallis test), and the relationship between ILS and factors investigated in the questionnaire (using Spearman's rank correlation coefficient). RESULTS: We observed that 30.7% of Japanese children exhibited an ILS and that the ILS rate increased with age (p < 0.001). There were no regional differences in the rate of ILS in Japanese children (p = 0.506). We revealed that 12 of 44 survey items exhibited a statistically significant correlation with ILS (p < 0.001), using Spearman's rank correlation coefficient. These items involved orofacial morphology, mouth breathing, and possibly, allergic rhinitis. CONCLUSION: The rate of ILS seems to increase with age in children, throughout Japan. Therefore, this disorder may not self-correct during the growth periods in these children. Guidelines are required for pediatric dentists to recognize ILS among children aged 3-12 years.

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  • スプーンを用いた捕食運動における小児期の特徴

    笹川 祐輝, 中村 由紀, 中島 努, 築野 沙絵子, 朴沢 美生, 五月女 哲也, 岩瀬 陽子, 齊藤 一誠, 早崎 治明

    新潟歯学会雑誌   50 ( 2 )   111 - 112   2020.12

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  • Drug-Induced Naïve iPS Cells Exhibit Better Performance than Primed iPS Cells with Respect to the Ability to Differentiate into Pancreatic β-Cell Lineage. International journal

    Yuki Kiyokawa, Masahiro Sato, Hirofumi Noguchi, Emi Inada, Yoko Iwase, Naoko Kubota, Tadashi Sawami, Miho Terunuma, Takeyasu Maeda, Haruaki Hayasaki, Issei Saitoh

    Journal of clinical medicine   9 ( 9 )   2020.9

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    Pluripotent stem cells are classified as naïve and primed cells, based on their in vitro growth characteristics and potential to differentiate into various types of cells. Human-induced pluripotent stem cells (iPSCs, also known as epiblast stem cells [EpiSCs]) have limited capacity to differentiate and are slightly more differentiated than naïve stem cells (NSCs). Although there are several in vitro protocols that allow iPSCs to differentiate into pancreatic lineage, data concerning generation of β-cells from these iPSCs are limited. Based on the pluripotentiality of NSCs, it was hypothesized that NSCs can differentiate into pancreatic β-cells when placed under an appropriate differentiation induction condition. We examined whether NSCs can be efficiently induced to form potentially pancreatic β cells after being subjected to an in vitro protocol. Several colonies resembling in vitro-produced β-cell foci, with β-cell-specific marker expression, were observed when NSC-derived embryoid bodies (EBs) were induced to differentiate into β-cell lineage. Conversely, EpiSC-derived EBs failed to form such foci in vitro. Intrapancreatic grafting of the in vitro-formed β-cell foci into nude mice (BALB/c-nu/nu) generated a cell mass containing insulin-producing cells (IPCs), without noticeable tumorigenesis. These NSCs can be used as a promising resource for curing type 1 diabetes.

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  • Development of microstructured fish scale collagen scaffolds to manufacture a tissue-engineered oral mucosa equivalent. Reviewed International journal

    Ayako Suzuki, Hiroko Kato, Takahiro Kawakami, Yoshihiro Kodama, Mayuko Shiozawa, Hiroyuki Kuwae, Keito Miwa, Emi Hoshikawa, Kenta Haga, Aki Shiomi, Atsushi Uenoyama, Issei Saitoh, Haruaki Hayasaki, Jun Mizuno, Kenji Izumi

    Journal of biomaterials science. Polymer edition   31 ( 5 )   578 - 600   2020.1

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    The present study aimed to develop a more biomimetic tissue-engineered oral mucosa equivalent comprising 1% type I tilapia scale collagen scaffold having microstructures mimicking the dermal-epidermal junction of oral mucosa and oral keratinocytes as graft materials for human use. We designed four micropattern prototypes mimicking the dermal-epidermal junction. Using a semiconductor process and soft lithography, negative molds were fabricated to develop microstructures using both polydimethylsiloxane and silicon substrates. Micropattern configurations of dermal-epidermal junctions manufactured from fish collagen consisting of a fibril network using our micropatterning system were well preserved, although the internal fibril network of the pillar pattern was sparse. Mixing 1% chondroitin sulfate with the collagen matrix minimized tissue-engineered oral mucosa equivalent contraction. Histologic examinations showed a flattening of the vertical dimensions of all microstructures and expansion of their pitches, indicating changes in the originally designed configurations. Nonetheless, histologic examinations revealed that a fully differentiated and stratified epithelial layer was developed on all scaffolds, suggesting that the microstructured fish scale collagen scaffolds have potential in the manufacturing of tissue-engineered oral mucosa equivalents for clinical use; however, enhancement of the mechanical properties of micropatterns is required. Our micropatterning technology can also apply to the development of oral mucosa in vitro models.

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  • Influence of food adhesivity and quantity in lip closing pressure. Reviewed International journal

    Nakamura Y, Nakajima T, Sasakawa Y, Tsukuno S, Sakurai R, Kurosawa M, Iwase Y, Saitoh I, Hori K, Hayashi T, Hayasaki H

    Physiology & behavior   214   112743 - 112743   2019.11

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    Lip closing is an important motor act in food acquisition. Appropriate food capture in anticipatory and early oral stages of feeding is essential for mastication and swallowing. The aim of this study was to investigate the effect of food type and quantity on lip closing pressure during food capture with a spoon, and to identify normal lip function during food acquisition in healthy young adults. Twenty young healthy males (age range: 22-30 years) participated in this study. They were asked to eat the test food freely with a spoon. Test foods were yogurt and cream cheese, which were given in quantities of 3, 5 and 10 g in weight; 3 ml water was included as a reference. A strain gauge transducer was embedded in the spoon in advance, and lip closing pressures during food capture were measured and recorded. The Vicon motion analysis system was used to collect three-dimensional kinematic data of spoon operation. Positive pressure with lip closing during capture of adhesive food, such as cream cheese, significantly increased (P < 0.001). Moreover, positive pressure significantly decreased when food quantity increased (P < 0.01), irrespective of food type. Negative pressure that preceded positive pressure appeared more frequently during cream cheese intake and increased when food quantity on the spoon increased (P < 0.001). These findings indicated that participants sucked or squeezed the spoon further during capture of adhesive food. Maximum mouth opening occurred predominantly during the spoon insertion period, while mouth closing occurred predominantly during the spoon withdrawal period. After mouth closing, all subsequent lip pressure events appeared in the withdrawal period. Our results may be useful for comprehending normal lip function during food acquisition in healthy young adults. They may also aid in the diagnosis and management of abnormal lip function in oral hypofunction and dysfunction, which can be examined in future studies.

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  • Comparison of dynamic occlusal contacts during chewing between children with primary dentition and normal adult females Reviewed

    Iwase Y, Saitoh I, Okamoto A, Kurosawa M, Nakamura Y, Inada E, Iwasaki T, Yamasaki Y, Hayasaki H

    Pediatric Dental Journal   29 ( 3 )   116 - 122   2019.8

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    Objective: Investigation of dynamic occlusal contacts when food particles are being pulverized during chewing is of interest for many researchers and clinicians. However, measurement of dynamic occlusal contacts during chewing is difficult, and differences between children and adults have not been established. The purpose of this study is to test the hypothesis that dynamic occlusal contacts of children differ from those of adult females.Subjects: and methods: Thirteen healthy children (4-6 years of age; mean age 5 years, 7 months) and thirteen adult females (18-26 years of age; mean age 20 years, 7 months) with normal occlusion participated in this study. Occlusal contact area (OCA) was estimated with a developed measurement system combining 3-D digitization of tooth shape with 3-D tracking of mandibular movements (1) during the closing stroke, (2) at the maximum closing position (MCP), and (3) during the opening stroke. OCA at static maximum intercuspation (ICP) was also estimated.Results: At the MCP, the children's OCA was less than 76.4% of the contact area seen at the ICP. The timing of maximum OCA in children was shifted more towards the opening stroke compared with adults, and the OCA remained greater during opening in children than adults. The occurrence of the MCP was less stable in children than in adults, both between subjects and within subjects.Conclusions: We conclude that both the amount of OCA and the pattern of occlusal contacts during the occlusal phase of chewing completely differ between children and adult females. (C) 2019 Japanese Society of Pediatric Dentistry. Published by Elsevier Ltd. All rights reserved.

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  • Study on effectiveness of tooth brushing instructions : Analysis from three-dimensional motions and plaque removal effects

    丸山 直美, 大島 邦子, 村井 朋代, 野上 有紀子, 中島 努, 花﨑 美華, 早﨑 治明

    日本歯科衛生学会雑誌   13 ( 2 )   52 - 60   2019.2

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  • Repeated human deciduous tooth-derived dental pulp cell reprogramming factor transfection yields multipotent intermediate cells with enhanced iPS cell formation capability. Reviewed International journal

    Soda M, Saitoh I, Murakami T, Inada E, Iwase Y, Noguchi H, Shibasaki S, Kurosawa M, Sawami T, Terunuma M, Kubota N, Terao Y, Ohshima H, Hayasaki H, Sato M

    Scientific Reports   9 ( 1 )   1490 - 1490   2019.2

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    Human tissue-specific stem cells (hTSCs), found throughout the body, can differentiate into several lineages under appropriate conditions in vitro and in vivo. By transfecting terminally differentiated cells with reprogramming factors, we previously produced induced TSCs from the pancreas and hepatocytes that exhibit additional properties than iPSCs, as exemplified by very low tumour formation after xenogenic transplantation. We hypothesised that hTSCs, being partially reprogrammed in a state just prior to iPSC transition, could be isolated from any terminally differentiated cell type through transient reprogramming factor overexpression. Cytochemical staining of human deciduous tooth-derived dental pulp cells (HDDPCs) and human skin-derived fibroblasts following transfection with Yamanaka's factors demonstrated increased ALP activity, a stem cell marker, three weeks after transfection albeit in a small percentage of clones. Repeated transfections (≤3) led to more efficient iPSC generation, with HDDPCs exhibiting greater multipotentiality at two weeks post-transfection than the parental intact HDDPCs. These results indicated the utility of iPSC technology to isolate TSCs from HDDPCs and fibroblasts. Generally, a step-wise loss of pluripotential phenotypes in ESCs/iPSCs occurs during their differentiation process. Our present findings suggest that the reverse phenomenon can also occur upon repeated introduction of reprogramming factors into differentiated cells such as HDDPCs and fibroblasts.

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  • 日本全国におけるエナメル質形成不全の有病率と地域差(Prevalence of molar incisor hypomineralization and regional differences throughout Japan) Reviewed International journal

    Saitoh Masato, Nakamura Yuki, Hanasaki Mika, Saitoh Issei, Murai Yuji, Kurashige Yoshihito, Fukumoto Satoshi, Asaka Yukiko, Yamada Masaaki, Sekine Michikazu, Hayasaki Haruaki, Kimoto Shigenari

    Environmental Health and Preventive Medicine   23 ( October )   1 - 6   2018.10

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    日本全国の7〜9歳児4496名を対象に、第一大臼歯と切歯に限局して発生するエナメル質形成不全(MIH)の有病率と全国8地域の差異を調査した。対象児の地域は妊娠時の母親の居住地とした。ロジスティック回帰分析を使用して、MIH有病率が年齢群、性別、地域間で異なるか否か評価した。その結果、日本全体のMIH有病率は19.8%であった。MIH有病率は、北海道地区が14.0%、東北地区が11.7%、関東信越地区が18.5%、東海北陸地区が19.3%、近畿地区が22.3%、中国地区が19.8%、四国地区が28.1%、九州地区が25.3%であり、この地域差は統計的に有意であった。また、MIH有病率は年齢とともに低下し、性別による差異は観察されなかった。以上から、MIHの有病率には地域差があり、北東部よりも南西部で頻度が高いことが判明した。

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  • Streptococcus pyogenes CAMP factor promotes calcium ion uptake in RAW264.7 cells. Reviewed International journal

    Kurosawa M, Oda M, Domon H, Isono T, Nakamura Y, Saitoh I, Hayasaki H, Yamaguchi M, Kawabata S, Terao Y

    Microbiology and Immunology   62 ( 10 )   617 - 623   2018.9

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    Streptococcus pyogenes is a bacterium that causes systemic diseases such as pharyngitis and toxic shock syndrome. S. pyogenes produces molecules that inhibit the function of the human immune system, thus allowing growth and spread of the pathogen in tissues. It is known that S. pyogenes CAMP factor induces vacuolation in macrophages; however, the mechanism remains unclear. In the current study, the mechanism by which CAMP factor induces vacuolation in macrophages was investigated. CAMP factor was found to induce calcium ion uptake in murine macrophage RAW264.7 cells. In addition, EDTA inhibited calcium ion uptake and vacuolation in the cells. The L-type voltage-dependent calcium ion channel blockers nifedipine and verapamil reduced vacuolation. Furthermore, the phosphoinositide 3-kinase inhibitors LY294002 and wortmannin also inhibited the vacuolation induced by CAMP factor. Fluorescent microscopy revealed that clathrin localized to the vacuoles. These results suggest that the vacuolation is related to calcium ion uptake by RAW264.7 cells via L-type voltage-dependent calcium ion channels. Therefore, it was concluded that the vacuoles induced by S. pyogenes CAMP factor in macrophages are clathrin-dependent endosomes induced by activation of the phosphoinositide 3-kinase signaling pathway through calcium ion uptake.

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  • An exploratory study of the factors related to mouth breathing syndrome in primary school children Reviewed International journal

    Issei Saitoh, Emi Inada, Yasutaka Kaihara, Yukiko Nogami, Daisuke Murakami, Naoko Kubota, Kaoru Sakurai, Yoshito Shirazawa, Tadashi Sawami, Miyuki Goto, Maki Nosou, Katsuyuki Kozai, Haruaki Hayasaki, Youichi Yamasaki

    Archives of Oral Biology   92   57 - 61   2018.8

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    Objective: Mouth breathing syndrome (MBS) is defined as a set of signs and symptoms that may be completely or incompletely present in subjects who, for various reasons, replace the correct pattern of nasal breathing with an oral or mixed pattern. It is important to identify the relevant factors affecting MBS in order to diagnose its cause since breathing obstructions can result from multiple factors. The purpose of this study is to clarify the relevant factors and the interrelationships between factors affecting MBS among children. Design: We surveyed 380 elementary school children from 6 to 12 years in age. The questionnaire consisted of 44 questions regarding their daily health conditions and lifestyle habits and was completed by the children's guardians. A factor analysis was performed to classify closely related questions into their respective factors and to examine the strength of the correlation between the newly revealed factors. Results: Twenty-six out of the 44 questions were selected, and they were classified into seven factors. Factors 1–7 were defined as “Incompetent lip seal”, “Diseases of the nose and throat”, “Eating and drinking habits”, “Bad breath”, “Problems with swallowing and chewing”, “Condition of teeth and gums”, and “Dry lips”, respectively. There were also correlations between these factors themselves. Conclusion: MBS was categorized according to 7 major factors. Because Factor 1 was defined as “Incompetent lip seal”, which was representative of the physical appearance of mouth breathers and correlated with other factors, we suggested that MBS should consist of 7 factors in total.

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  • A Case of Very Early-Onset Crohn's Disease Presenting With Intractable Stomatitis and Cheilitis as Its Major Signs Reviewed

    Saitoh I, Kurosawa M, Nagai H, Fujii T, Aoyagi Y, Nakakura-Ohshima K, Iwase Y, Hayasaki H, Shirakawa T

    Clinical Advances in Periodontics   8 ( 2 )   67 - 71   2018.6

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    BackgroundOral inflammatory lesions assist in the diagnosis of certain systemic diseases that primarily affect other organs.MethodsA young girl, 3 years and 3 months old, presented with aphthous stomatitis, upper lip cheilitis, and swelling and bleeding of the upper gingiva. She had a medical history of repeated fever, skin tag of the anus, and constipation. Thus, it was suspected that her disease is a systemic disease with digestive symptoms. From clinical manifestation and endoscopy findings containing aphthoid ulcers in the bowel, she was diagnosed with very early-onset Crohn's disease (CD). Immediately, mesalazine was started.ResultsAfter 1 month, the oral symptoms were dramatically improved, and her general condition stabilized.ConclusionsOral symptoms often precede the appearance of gastrointestinal lesions in young CD patients, and oral conditions worsen if the disease remains untreated. Thus, assessment of patients with intractable stomatitis from the viewpoint of CD may aid in rapid diagnosis and better prognosis.

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  • Gender difference of tooth brushing motion and force on self-brushing and caregivers' brushing in dental professionals Reviewed

    Hanasaki M, Nakakura-Ohshima K, Nakajima T, Nogami Y, Hayasaki H

    Dental, Oral and Craniofacial Research   4 ( 4 )   2018.3

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  • A novel method to evaluate interproximal accessibility of caregivers’ tooth brushing by using “invisibility” eyeglasses Reviewed

    Nakakura-Ohshima K, Hanasaki M, Nogami Y, Murakami N, Nakajima T, Hayasaki H

    Dental, Oral and Craniofacial Research   4 ( 4 )   2018.1

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  • Streptococcus pyogenes CAMP factor promotes bacterial adhesion and invasion in pharyngeal epithelial cells without serum via PI3K/Akt signaling pathway. Reviewed International journal

    Kurosawa M, Oda M, Domon H, Isono T, Nakamura Y, Saitoh I, Hayasaki H, Yamaguchi M, Kawabata S, Terao Y

    Microbes and Infection   20 ( 1 )   9 - 18   2018.1

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    Streptococcus pyogenes is a bacterium that causes systemic diseases, such as pharyngitis and toxic shock syndrome, via oral- or nasal-cavity infection. S. pyogenes produces various molecules known to function with serum components that lead to bacterial adhesion and invasion in human tissues. In this study, we identified a novel S. pyogenes adhesin/invasin. Our results revealed that CAMP factor promoted streptococcal adhesion and invasion in pharyngeal epithelial Detroit562 cells without serum. Recombinant CAMP factor initially localized on the membranes of cells and then became internalized in the cytosol following S. pyogenes infection. Additionally, CAMP factor phosphorylated phosphoinositide 3-kinase and serine-threonine kinase in the cells. ELISA results demonstrate that CAMP factor affected the amount of phosphorylated phosphoinositide 3-kinase and serine-threonine kinase in Detroit562 cells. Furthermore, CAMP factor did not reverse the effect of phosphoinositide 3-kinase knockdown by small interfering RNA in reducing the level of adhesion and invasion of S. pyogenes isogenic cfa-deficient mutant. These results suggested that S. pyogenes CAMP factor activated the phosphoinositide 3-kinase/serine-threonine kinase signaling pathway, promoting S. pyogenes invasion of Detroit562 cells without serum. Our findings suggested that CAMP factor played an important role on adhesion and invasion in pharyngeal epithelial cells.

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  • Dental caries prevalence and treatment level of neglected children at two child guidance centers Reviewed

    Yukiko Nogami, Yoko Iwase, Akiko Kagoshima, Issei Saitoh, Tsutomu Nakajima, Hideki Takahashi, Kanehito Nakagawa, Akihiro Yoshihara, Akitsugu Ohuchi, Tomiko Asahito, Haruaki Hayasaki

    Pediatric Dental Journal   27 ( 3 )   137 - 141   2017.12

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    Objective Detailed evidence of a relationship between maltreated children and dental caries is limited. The purpose of this study was to investigate the prevalence of dmft and DMFT, and the characteristics of dental treatment level of children at two child guidance centers (CGC). Subject and methods A total of 166 children (mean age: 11.6 y ± 2.8) staying at two CGCs were examine, and their results were compared with those of the Survey of Dental Disease (SDD) carried out by the Japanese Society for Oral Health. Results Mean numbers of dental caries were 5.70 at the CGCs and 2.25 in the SDD. “Completely treated” children were 21.7% of total participants in the SDD, but only 3.6% at the CGCs. In addition, 7.0% of participants were “untreated” in the SDD, but 41.0% at the CGCs. The percentage of children without dental caries was 18.7% at the CGCs and 45.7% in the SDD. These differences between the CGCs and in the SDD were statistically significant. Conclusions Our results indicate that, due to a lack of daily oral care, dental caries are significantly more prevalent in children at CGCs. CGCs may be good places to improve neglected children's dental caries and oral health care.

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  • Unilateral open-bite caused by an impacted primary molar with ankylosis: A case report Reviewed

    Issei Saitoh, Satoshi Fukumoto, Yoko Iwase, Haruaki Hayasaki, Youichi Yamasaki

    Pediatric Dental Journal   27 ( 3 )   147 - 152   2017.12

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    Management of the developing dentition and occlusion performs early and healthy oral optimization by diagnosing and treating their malocclusion and dysfunction in optimal period. We treated a posterior open-bite triggered by an impacted tooth with ankylosis. Her second primary molar was impacted with ankylosis of the buccal roots. She usually had her tongue thrust against her right posterior teeth. Timely and actively accelerated eruption of her second premolar was produced by extracting her second primary molar with fenestration. Her result shows the importance of improving oral habits and treating the submersion in the optimal period during early growth.

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  • 横断研究で示された口唇閉鎖力の強さと関連因子との関連性(The relationship between lip-closing strength and the related factors in a cross-sectional study) Reviewed

    Saitoh Issei, Inada Emi, Kaihara Yasutaka, Nogami Yukiko, Murakami Daisuke, Ishitani Norihito, Sawami Tadashi, Iwase Yoko, Nakajima Tsutomu, Kubota Naoko, Sakurai Kaoru, Tsujii Toshiya, Shirazawa Yoshito, Hanasaki Mika, Kurosawa Mie, Goto Miyuki, Nosou Maki, Kozai Katsuyuki, Yamasaki Youichi, Hayasaki Haruaki

    Pediatric Dental Journal   27 ( 3 )   115 - 120   2017.12

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    口唇閉鎖力の強さ(LCS)の年齢に関連して変化するパターンや、その他の関連因子を調査する横断研究を施行した。日本人の小児554名(女児275名、年齢3〜12歳)を調査対象とした。口唇閉鎖力測定器の「りっぷるくん」を用いてLCSを測定し、被験児の親に対して質問紙調査を行った。検討の結果、LCSは3〜6歳にかけて年齢と共に増大したが7〜12歳では平坦相に達し、そのパターンはScammonの発育曲線における一般型に類似していた。3〜6歳児の集団では、調査項目のうち「年齢」とLCSとの間の相関係数は他の項目に比べて高かった。7〜12歳児では「性別」や「食事中に飲み物を飲むこと」がLCSと中等度に相関していた。小児のLCSに関しては、発達期(3〜6歳)と安定期(7〜12歳)の2つの時期が区別されることが示された。

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  • Comparison of dynamic occlusal contacts during chewing between working and balancing sides Reviewed

    Kurosawa M, Saitoh I, Iwase Y, Inada E, Nogami Y, Murakami N, Shibasaki S, Murakami T, Iwasaki T, Matsueda K, Nakamura Y, Yamasaki Y, Hayasaki H

    Dental, Oral and Craniofacial Research   4 ( 2 )   2017.11

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  • Change in masticatory movement according to food size in young Japanese females. Reviewed

    Kitte E, Nakamura Y, Nakajima T, Hanasaki M, Nogami Y, Sasakawa Y, Iwase Y, Kurosawa M, Oku T, Saitoh I, Hayasaki H

    Dental, Oral and Craniofacial Research   4 ( 2 )   2017.10

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  • Difference of toothbrushing motion between dental hygienists and mothers -Focusing on self-toothbrushing and caregivers’-toothbrushing Reviewed

    Nakajima T, Nakakura-Ohshima K, Hanasaki M, Nogami Y, Murakami N, Nakamura Y, Saitoh I, Hayasaki H

    Dental, Oral and Craniofacial Research   4 ( 1 )   2017.9

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  • Isolation and characterization of lymphoid enhancer factor-1-positive deciduous dental pulp stem-like cells after transfection with a piggyBac vector containing LEF1 promoter-driven selection markers Reviewed International journal

    Tomoya Murakami, Issei Saitoh, Masahiro Sato, Emi Inada, Miki Soda, Masataka Oda, Hisanori Domon, Yoko Iwase, Tadashi Sawami, Kazunari Matsueda, Yutaka Terao, Hayato Ohshima, Hirofumi Noguchi, Haruaki Hayasaki

    ARCHIVES OF ORAL BIOLOGY   81   110 - 120   2017.9

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    Objective: Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. LEF1 is also an important member of the Wnt/beta-catenin signaling pathway that plays important roles in the self-renewal and differentiation of embryonic stem cells. We speculated that LEF1 might function in the stem cells from human exfoliated deciduous teeth (SHED). In this study, we attempted to isolate such LEF1-positive cells from human deciduous dental pulp cells (HDDPCs) by genetic engineering technology, using the human LEF1 promoter.
    Design: A piggyBac transposon plasmid (pTA-LEN) was introduced into HDDPCs, using the Neon (R) transfection system. After G418 selection, the emerging colonies were assessed for EGFP-derived fluorescence by fluorescence microscopy. Reverse transcription polymerase chain reaction (RT-PCR) analysis was performed using RNA isolated from these colonies to examine stem cell-specific transcript expression. Osteoblastic or neuronal differentiation was induced by cultivating the LEF1-positive cells with differentiation-inducing medium.
    Results: RT-PCR analysis confirmed the expression of several stem cell markers, including OCT3/4, SOX2, REX1, and NANOG, in LEF1-positive HDDPCs, which could be differentiated into osteoblasts and neuronal cells.
    Conclusions: The isolated LEF1-positive HDDPCs exhibited the properties of stem cells, suggesting that LEF1 might serve as a marker for SHED.

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  • Reconsidering the treatment plan for traumatized teeth – A case of lateral luxation with severe displacement Reviewed

    Tsutomu Nakajima, Yoko Iwase, Issei Saitoh, Yukiko Nogami, Kazunari Matsueda, Haruaki Hayasaki

    Pediatric Dental Journal   27 ( 2 )   109 - 113   2017.8

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    Objective International association dental traumatology has published guideline for the primary dentition. The guideline indicates that, when the crown is dislocated in a labial direction, extraction of the affected tooth is the only choice of treatment for lateral luxation cases with severe displacement. However, retaining primary teeth is important. Here we present a case of a tooth with lateral luxation and severe displacement. Case A three-year-old girl presented with complaint of severe mobility of the left lower primary canine caused by hitting a water tap 1 month earlier. Result We performed a root canal filling after pulpectomy and crown height reducing. After 37 weeks, radiographic examination showed dramatically alveolar bone regeneration and we were able to treat and maintain. Conclusion We conclude that conservative treatment of a traumatized tooth can be effective even in cases of lateral luxation and severe displacement.

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  • Oral feeding behavior during a whole meal Reviewed

    Murakami N, Nakamura Y, Nakajima T, Sasakawa Y, Nakakura-Ohshima K, Murakami T, Kurosawa M, Iwase Y, Murakami D, Saitoh I, Inada E, Yamasaki Y, Hayasaki H

    Dental, Oral and Craniofacial Research   4 ( 1 )   2017.1

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  • Tissue-Specific Stem Cells Obtained by Reprogramming of Non-Obese Diabetic (NOD) Mouse-Derived Pancreatic Cells Confer Insulin Production in Response to Glucose Reviewed

    Issei Saitoh, Masahiro Sato, Miki Soda, Emi Inada, Yoko Iwase, Tomoya Murakami, Hayato Ohshima, Haruaki Hayasaki, Hirofumi Noguchi

    PLOS ONE   11 ( 9 )   e0163580   2016.9

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    Type 1 diabetes occurs due to the autoimmune destruction of pancreatic beta-cells in islets. Transplantation of islets is a promising option for the treatment of patients with type 1 diabetes that experience hypoglycemic unawareness despite maximal care, but the present shortage of donor islets hampers such transplantation. Transplantation of insulin-producing cells derived from the patients themselves would be one of the most promising approaches to cure type 1 diabetes. Previously, we demonstrated that insulin-producing cells could be produced by transfecting murine pancreatic cells with Yamanaka's reprogramming factors. Non-obese diabetic (NOD) mice are naturally occurring mutant mice defective in insulin production due to autoimmune ablation of pancreatic beta-cells. In this study, we showed that glucose-sensitive insulin-producing cells are successfully generated by transfecting primary pancreatic cells from NOD mice (aged 6 months old) with a plasmid harboring the cDNAs for Oct-3/4, Sox2, Klf4, and c-Myc. Transfection was repeated 4 times in a 2 day-interval. Sixty-five days after final transfection, cobblestone-like colonies appeared. They proliferated in vitro and expressed pluripotency-related genes as well as Pdx1, a transcription factor specific to tissue-specific stem cells for the beta-cell lineage. Transplantation of these cells into nude mice failed to produce teratoma unlike induced pluripotent stem cells (iPSCs). Induction of these cells to the pancreatic beta-cell lineage demonstrated their capability to produce insulin in response to glucose. These findings suggest that functional pancreatic beta-cells can be produced from patients with type 1 diabetes. We call these resultant cells as "induced tissue-specific stem cells from the pancreas" (iTS-P) that could be valuable sources of safe and effective materials for cell-based therapy in type 1 diabetes.

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  • 知的障害者施設入所者における在所期間と口腔内状態および口腔に関連する支援状態の関連 Reviewed

    石川 裕子, 米澤 大輔, 葭原 明弘, 齊藤 一誠, 早崎 治明

    口腔衛生学会雑誌   66 ( 3 )   338 - 343   2016.4

  • 自己による歯磨きと養育者による歯磨きにおける歯ブラシの動きと強さの違いに関する性差(Gender Differences of Tooth Brushing Motion and Force in Self-Brushing and Caregiver's Brushing) Reviewed

    Hanasaki Mika, Ohshima-Nakakura Kuniko, Nogami Yukiko, Nakajima Tsutomu, Kagoshima Akiko, Murakami Nozomi, Hayasaki Haruaki

    小児歯科学雑誌   54 ( 2 )   271 - 271   2016.4

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  • Streptococcus pyogenes CAMP factor attenuates phagocytic activity of RAW 264.7 cells Reviewed International journal

    Mie Kurosawa, Masataka Oda, Hisanori Domon, Issei Saitoh, Haruaki Hayasaki, Yutaka Terao

    MICROBES AND INFECTION   18 ( 2 )   118 - 127   2016.2

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    Streptococcus pyogenes produces molecules that inhibit the function of human immune system, thus allowing the pathogen to grow and spread in tissues. It is known that S. pyogenes CAMP factor increases erythrocytosis induced by Staphylococcus aureus beta-hemolysin. However, the effects of CAMP factor for immune cells are unclear. In this study, we investigated the effects of CAMP factor to macrophages. Western blotting analysis demonstrated that all examined strains expressed CAMP factor protein. In the presence of calcium or magnesium ion, CAMP factor was significantly released in the supernatant. In addition, both culture supernatant from S. pyogenes strain SSI-9 and recombinant CAMP factor dose-dependently induced vacuolation in RAW 264.7 cells, but the culture supernatant from Delta cfa isogenic mutant strain did not. CAMP factor formed oligomers in RAW 264.7 cells in a time-dependent manner. CAMP factor suppressed cell proliferation via G2 phase cell cycle arrest without inducing cell death. Furthermore, CAMP factor reduced the uptake of S. pyogenes and phagocytic activity indicator by RAW 264.7 cells. These results suggest that CAMP factor works as a macrophage dysfunction factor. Therefore, we conclude that CAMP factor allows S. pyogenes to escape the host immune system, and contribute to the spread of streptococcal infection. (C) 2015 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

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  • Choice of Feeders Is Important When First Establishing iPSCs Derived From Primarily Cultured Human Deciduous Tooth Dental Pulp Cells. Reviewed International journal

    Saitoh I, Inada E, Iwase Y, Noguchi H, Murakami T, Soda M, Kubota N, Hasegawa H, Akasaka E, Matsumoto Y, Oka K, Yamasaki Y, Hayasaki H, Sato M

    Cell Medicine   8 ( 1-2 )   9 - 23   2015.12

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    Feeder cells are generally required to maintain embryonic stem cells (ESCs)/induced pluripotent stem cells (iPSCs). Mouse embryonic fibroblasts (MEFs) isolated from fetuses and STO mouse stromal cell line are the most widely used feeder cells. The aim of this study was to determine which cells are suitable for establishing iPSCs from human deciduous tooth dental pulp cells (HDDPCs). Primary cultures of HDDPCs were cotransfected with three plasmids containing human OCT3/4, SOX2/KLF4, or LMYC/LIN28 and pmaxGFP by using a novel electroporation method, and then cultured in an ESC qualified medium for 15 days. Emerging colonies were reseeded onto mitomycin C-treated MEFs or STO cells. The colonies were serially passaged for up to 26 passages. During this period, colony morphology was assessed to determine whether cells exhibited ESC-like morphology and alkaline phosphatase activity to evaluate the state of cellular reprogramming. HDDPCs maintained on MEFs were successfully reprogrammed into iPSCs, whereas those maintained on STO cells were not. Once established, the iPSCs were maintained on STO cells without loss of pluripotency. Our results indicate that MEFs are better feeder cells than STO cells for establishing iPSCs. Feeder choice is a key factor enabling efficient generation of iPSCs.

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  • Analysis of tooth brushing cycles Reviewed International journal

    Yuki Tosaka, Kuniko Nakakura-Ohshima, Nozomi Murakami, Rikako Ishii, Issei Saitoh, Yoko Iwase, Akihiro Yoshihara, Akitsugu Ohuchi, Haruaki Hayasaki

    CLINICAL ORAL INVESTIGATIONS   18 ( 8 )   2045 - 2053   2014.11

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    The aim of this study was to demonstrate the effectiveness of an analysis of tooth brushing cycles using a system that measures tooth brushing motion and brushing force with an accelerometer and strain tension gage attached to a toothbrush.
    Mechanical plaque removal with a manual toothbrush remains the primary method of maintaining good oral hygiene for the majority of the population. Because toothbrush motion has not been fully understood, it should be clarified by analysis of tooth brushing cycles.
    Twenty healthy female dental hygienists participated in this study. Their tooth brushing motions were measured and analyzed using an American Dental Association-approved manual toothbrush to which a three-dimensional (3-D) accelerometer and strain tension gage were attached. 3-D motion and brushing force on the labial surface of the mandibular right central incisor and the lingual surface of the mandibular left first molar were measured, analyzed, and compared. Multilevel linear model analysis was applied to estimate variables and compare motion and forces related to the two tooth surfaces.
    The analysis of tooth brushing cycles was feasible, and significant differences were detected for durations and 3-D ranges of toothbrush motion as well as brushing force between the two tooth surfaces.
    The analysis used in this study demonstrated an ability to detect characteristics of tooth brushing motion, showing tooth brushing motion to change depending on the brushed location. These results also suggest that more detailed instructions might be required according to patient's oral condition.

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  • Relationship between nasal and skeletal landmarks on lateral cephalograms of adults Reviewed

    Emi Inada, Issei Saitoh, Daisuke Murakami, Naoko Kubota, Yoshihiko Takemoto, Tomonori Iwasaki, Kuniko Nakakura-Ohshima, Haruaki Hayasaki, Youichi Yamasaki

    AUSTRALIAN JOURNAL OF FORENSIC SCIENCES   46 ( 3 )   339 - 347   2014.9

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    The purpose of this study was to investigate the relationship between cephalometric nasal soft tissue and skeletal landmarks in adults. Lateral cephalograms from Japanese adults (30 men: mean age, 24.5 +/- 4.9years; 30 women: mean age, 20.3 +/- 3.3years; overall mean age, 22.4 +/- 2.4years) were used in this study. Twenty-two skeletal points and three soft tissue nasal points were marked on each subject's lateral cephalogram, and the coordinates of all the points were systematically digitised and transformed to a standardised plane. A forward stepwise regression analysis determined how combinations of the skeletal landmarks predict the location of the nasal soft tissue landmarks. Based on the result of our research, the location of the nasal soft tissue cephalometric landmarks in our adult subjects may be predicted based on skeletal landmarks, and different skeletal landmarks predicted the position of each soft tissue landmark in the adult males and females in this study.

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  • Tooth brushing for oral prophylaxis Reviewed

    Hayasaki H, Saitoh I, Nakakura-Ohshima K, Hanasaki M, Nogami Y, Nakajima T, Inada E, Iwasaki T, Iwase Y, Sawami T, Kawasaki K, Murakami N, Murakami T, Kurosawa M, Kimi M, Kagoshima A, Soda M, Yamasaki Y

    Japanese Dental Science Review   50 ( 3 )   69 - 77   2014.8

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  • STO Feeder Cells Are Useful for Propagation of Primarily Cultured Human Deciduous Dental Pulp Cells by Eliminating Contaminating Bacteria and Promoting Cellular Outgrowth. Reviewed International journal

    Murakami T, Saitoh I, Inada E, Kurosawa M, Iwase Y, Noguchi H, Terao Y, Yamasaki Y, Hayasaki H, Sato M

    Cell medicine   6 ( 1-2 )   75 - 81   2013.12

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    STO feeder cells, a line established from mouse SIM embryonic fibroblasts, have been frequently used for establishing embryonic stem cells and maintaining them in an undifferentiated state. There are some reports demonstrating that fibroblastic cells have the ability to phagocytose Gram-positive bacterium (e.g., streptococci and staphylococci). In this study, we examined the possibility that STO cells could phagocytose Streptococcus mutans (a bacteria causing tooth decay), which always contaminates cultures of primarily isolated human deciduous dental pulp cells (HDDPCs). Simple cultivation of the primary HDDPCs in the absence of STO cells allowed S. mutans to massively propagate in the medium, thus leading to an opaque medium. In contrast, there was no bacterial contamination in the cultures containing mitomycin C (MMC)-inactivated STO cells. Furthermore, STO cells indicated bacterial phagocytic activity under fluorescent microscopy with the dye pHrodo. Besides removal of contaminating bacteria, STO feeder cells allowed the HDDPCs to spread out. These data suggest that MMC-treated STO cells can be useful for propagation of HDDPCs by eliminating contaminating bacteria and by promoting cellular outgrowth.

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  • Smoothness of Molar Movement During Gum Chewing in Children with Primary Dentition Reviewed International journal

    Chiaki Yamada-Ito, Issei Saitoh, Kohtaro Yashiro, Emi Inada, Tomoaki Maruyama, Kenji Takada, Tomonori Iwasaki, Haruaki Hayasaki, Youichi Yamasaki

    CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE   31 ( 4 )   260 - 269   2013.10

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    The purpose of this study was to test the null hypothesis that molar movement during gum chewing in children with primary dentition is as smooth as in adults. Twenty-two healthy children with primary dentition and 23 healthy adult females participated in this study. Mandibular movement during gum chewing was recorded using an optoelectronic analysis system with six degrees-of-freedom at 100 Hz, and 10 cycles were selected for analysis. Normalized jerk cost (NJC) at the incisors and working and balancing molars were calculated in each phase (i.e., opening, closing and occlusal level phases) for each chewing cycle. The NJC of the working side molar in children was larger than in adults in both the opening and occlusal phases. Inter-individual variances of the NJC in each phase in children and adults were smaller than corresponding intra-individual variances, except for the NJC during the occlusal phase of adults for the working and balancing side molars. The inter- and intra-individual variances of the NJC during the closing phase were the smallest in each phase for both children and adults. This indicates that the jaw movements of children with primary dentition are more variable, less smooth, and faster than that of adults.

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  • Tongue posture improvement and pharyngeal airway enlargement as secondary effects of rapid maxillary expansion: A cone-beam computed tomography study Reviewed International journal

    Tomonori Iwasaki, Issei Saitoh, Yoshihiko Takemoto, Emi Inada, Eriko Kakuno, Ryuzo Kanomi, Haruaki Hayasaki, Youichi Yamasaki

    AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS   143 ( 2 )   235 - 245   2013.2

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    Introduction: Rapid maxillary expansion (RME) is known to improve nasal airway ventilation. Recent evidence suggests that RME is an effective treatment for obstructive sleep apnea in children with maxillary constriction. However, the effect of RME on tongue posture and pharyngeal airway volume in children with nasal airway obstruction is not clear. In this study, we evaluated these effects using cone-beam computed tomography. Methods: Twenty-eight treatment subjects (mean age 9.96 +/- 1.21 years) who required RME treatment had cone-beam computed tomography images taken before and after RME. Twenty control subjects (mean age 9.68 +/- 1.02 years) received regular orthodontic treatment. Nasal airway ventilation was analyzed by using computational fluid dynamics, and intraoral airway (the low tongue space between tongue and palate) and pharyngeal airway volumes were measured. Results: Intraoral airway volume decreased significantly in the RME group from 1212.9 +/- 1370.9 mm(3) before RME to w279.7 +/- 472.0 mm(3) after RME. Nasal airway ventilation was significantly correlated with intraoral airway volume. The increase of pharyngeal airway volume in the control group (1226.3 +/- 1782.5 mm(3)) was only 41% that of the RME group (3015.4 +/- 1297.6 mm(3)). Conclusions: In children with nasal obstruction, RME not only reduces nasal obstruction but also raises tongue posture and enlarges the pharyngeal airway. (Am J Orthod Dentofacial Orthop 2013;143:235-45)

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  • Analysis of upper airway obstruction in Class II children using fluid-mechanical simulation Reviewed

    Youichi Yamasaki, Tomonori Iwasaki, Issei Saitoh, Yoshihiko Takemoto, Emi Inada, Eriko Kakuno, Ryuzo Kanomi, Haruaki Hayasaki

    Proceeding of the 8th Biennial Conference of the Pediatric Dentistry Association of Asia (PDAA) / The 5 finalists of Scientific competition in Research Poster Session   386 - 401   2012.5

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  • Association between mouth opening and upper body movement with intake of different-size food pieces during eating

    E. Inada, I. Saitoh, K. Nakakura-Ohshima, T. Maruyama, T. Iwasaki, D. Murakami, M. Tanaka, H. Hayasaki, Y. Yamasaki

    Archives of Oral Biology   57   307 - 313   2012.3

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    Head rotation is coordinated with mandibular movement during mouth opening, and the range of head rotation and mouth opening change with food size. However, past research did not include upper body movement, and no reports have related head and mandibular movement during realistic eating. The purpose of this study was to analyse head and mandibular movements with intake of different-sized food pieces during realistic eating. The test food consisted of apple cut into two different cube sizes (10 mm and 20 mm). Head and mandibular movements of 20 healthy young adults eating the apple pieces were simultaneously recorded in three dimensions by a wireless opto-electronic system. Reflective markers were attached to the upper lip and chin to measure the mouth opening range. Five markers were attached to eyeglasses frames to measure linear motion and rotation of the head. One marker was attached to the jugular notch of the sternum to measure linear motion of the upper body. Linear motion, and the inclination angle of the head and upper body, and mouth opening range were compared during intake of different-sized apple pieces. Mouth opening, head-neck rotation angle and the amount of upper body forward translation and inclination increased with larger apple pieces. However, isolated relative head motion was stabilized. We conclude that upper body forward motion and head-neck rotation assist mouth opening whilst stabilizing head orientation, and that the range of head-neck rotation angle, upper body translation and range of mouth opening change with food size during realistic eating. © 2011 Elsevier Ltd.

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  • Improvement of nasal airway ventilation after rapid maxillary expansion evaluated with computational fluid dynamics Reviewed International journal

    Tomonori Iwasaki, Issei Saitoh, Yoshihiko Takemoto, Emi Inada, Ryuzo Kanomi, Haruaki Hayasaki, Youichi Yamasaki

    AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS   141 ( 3 )   269 - 278   2012.3

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    Introduction: Rapid maxillary expansion is known to improve nasal airway ventilation. However, it is difficult to precisely evaluate this improvement with conventional methods. The purpose of this longitudinal study was to use computational fluid dynamics to estimate the effect of rapid maxillary expansion. Methods: Twenty-three subjects (9 boys, 14 girls; mean ages, 9.74 +/- 1.29 years before rapid maxillary expansion and 10.87 +/- 1.18 years after rapid maxillary expansion) who required rapid maxillary expansion as part of their orthodontic treatment had cone-beam computed tomography images taken before and after rapid maxillary expansion. The computed tomography data were used to reconstruct the 3-dimensional shape of the nasal cavity. Two measures of nasal airflow function (pressure and velocity) were simulated by using computational fluid dynamics. Results: The pressure after rapid maxillary expansion (80.55 Pa) was significantly lower than before rapid maxillary expansion (147.70 Pa), and the velocity after rapid maxillary expansion (9.63 m/sec) was slower than before rapid maxillary expansion (13.46 m/sec). Conclusions: Improvement of nasal airway ventilation by rapid maxillary expansion was detected by computational fluid dynamics. (Am J Orthod Dentofacial Orthop 2012; 141:269-78)

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  • Evaluation of improvement of nasal airway ventilation following rapid maxillary expansion using computational fluid dynamics Reviewed

    Tomonori Iwasaki, Issei Saitoh, Yoshihiko Takemoto, Emi Inada, Ryuzo Kanomi, Haruaki Hayasaki, Youichi Yamasaki

    American Journal of Orthodontics & Dentofacial Orthopedics   141 ( 3 )   269 - 278   2012.3

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  • Comparison of Normal Permanent and Primary Dentition Sagittal Tooth-Crown Inclinations of Japanese Females Reviewed International journal

    Emi Inada, Issei Saitoh, Haruaki Hayasaki, Yoko Iwase, Naoko Kubota, Yoshihiko Takemoto, Youichi Yamasaki

    CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE   30 ( 1 )   41 - 51   2012.1

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    The purpose of this study was to clarify the characteristics of permanent and primary tooth-crown inclinations. Landmark points from cephalograms and dental casts of two groups; 23 women (mean 20.3 +/- 3.3 years) and 11 girls (mean 5.2 +/- 0.1 years) were digitized, ad the coordinates were integrated and transformed to a standardized plane. The 3-dimensional crown inclinations were projected on the sagittal plane, and the angles between the tooth vectors and the FH plane were calculated. An independent-group t-test was used to test for group differences of each tooth inclination, and correlation coefficients were generated for the inclination angles among the permanent and primary teeth. Most maxillary tooth-crown inclinations showed significant age-related differences, while only the second premolar and primary second molar differed significantly in the mandible. The maxillary molars were parallel to the corresponding mandibular molars and correlated with each other, but the primary molars were not. Significant correlations were found between inclinations of most permanent teeth, but not the primary teeth. Maxillary tooth-crown inclinations change during growth, but tooth-crown inclinations of the mandibular teeth do not.

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  • Do occlusal contact areas of maximum closing position during gum chewing and intercuspal position coincide? Reviewed International journal

    Yoko Iwase, Issei Saitoh, Atsuyoshi Okamoto, Kuniko Nakakura-Ohshima, Emi Inada, Chiaki Yamada, Yoshihiko Takemoto, Youichi Yamasaki, Haruaki Hayasaki

    ARCHIVES OF ORAL BIOLOGY   56 ( 12 )   1616 - 1623   2011.12

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    Objective: Occlusal contact area (OCA) is most important during the occlusal phase when food particles are being pulverized. OCA is most easily measured statically at the maximum intercuspal position (ICP). However, the assumption of coincidence between dynamic maximum closing position (MCP) and statically determined ICP has not been previously tested. The purpose of this study is to introduce a method of quantifying OCA of all teeth during dynamic mastication to determine whether the OCA at the dynamic MCP during chewing is similar to the statically determined maximum possible OCA.
    Design: Thirteen healthy females participated in this study. Morphologic tooth shape data were measured from dental models using an automatic 3D digitizer. Mandibular movement during gum chewing was recorded using an optoelectronic analysis system with 6 degrees of freedom, and ten cycles were selected for analysis. The dynamic OCA was estimated with a measurement system combining 3D tracking of mandibular movements with 3D digitization of tooth shape.
    Results: The estimated mean 3D difference between the incisor position at ICP and MCP was 0.129 mm. At the dynamic MCP, the maximum OCA was 98.5% (68.42 mm(2)) of the maximum possible contact area in the static ICP (69.46 mm(2)). Both between-subject and within-subject variation were least at the dynamic MCP.
    Conclusion: The maximum OCA during chewing is nearly identical to statically determined maximum possible OCA. (C) 2011 Elsevier Ltd. All rights reserved.

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  • Evaluation of upper airway obstruction in Class II children with fluid-mechanical simulation Reviewed International journal

    Tomonori Iwasaki, Issei Saitoh, Yoshihiko Takemoto, Emi Inada, Ryuzo Kanomi, Haruaki Hayasaki, Youichi Yamasakie

    AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS   139 ( 2 )   e135 - 45   2011.2

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    Introduction: The purpose of this study was to test the null hypothesis that dolichofacial and brachyfacial children with Class II malocclusion do not differ in upper airway obstruction. Furthermore, the ability of fluid-mechanical simulation to detect airway obstruction within the limitations of simulation was examined. Methods: Forty subjects from 7 to 11 years of age with Class II malocclusion participated and were divided into 2 groups, dolichofacial and brachyfacial, based on their Frankfort mandibular plane angles. Cone-beam computed tomography images supplied the shape of the entire airway. Two measures of respiratory function, air velocity and pressure, were simulated by using 3-dimensional images of the airway. The images and simulations were compared between the 2 facial types. Results: The size of the upper airway did not differ statistically between facial types; however, the simulated maximal pressure and velocity of the dolichofacial type were significantly higher than those of the brachyfacial type. Conclusions: Airway obstruction differs with the Frankfort mandibular plane angle, even though the depth and cross-sectional area of the airway do not. The fluid-mechanical simulation system developed in this study detected differences in airway obstruction that were not apparent from morphologic studies. (Am J Orthod Dentofacial Orthop 2011;139:e135-e145)

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  • Pharyngeal airway in children with prognathism and normal occlusion Reviewed International journal

    Yoshihiko Takemoto, Issei Saitoh, Tomonori Iwasaki, Emi Inada, Chiaki Yamada, Yoko Iwase, Miyuki Shinkai, Ryuzo Kanomi, Haruaki Hayasaki, Youichi Yamasaki

    ANGLE ORTHODONTIST   81 ( 1 )   75 - 80   2011.1

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    Objective: To test the hypothesis that there is no difference in the pharyngeal airway width and the position of the maxillofacial skeleton between prognathic and normal children.
    Materials and Methods: Twenty-five girls with prognathism (mean, 7.9 +/- 0.9 years old) and 15 girls with normal occlusion (mean, 8.4 +/- 1.5 years) participated in this study. On each girl's lateral cephalogram, the coordinates of all points were marked and systematically digitized using a mechanical three-dimensional digitizing system. An independent-groups t-test was used to detect significant upper and lower pharyngeal width differences between the two groups. Correlations between the horizontal positions of each point and upper and lower pharyngeal widths were examined.
    Results: Prognathic girls had a significantly wider lower pharyngeal airway compared with those with normal occlusion (P = .01). Furthermore, the horizontal coordinate of Ar was significantly positively correlated with lower pharyngeal airway width in both groups of girls.
    Conclusions: The hypothesis is rejected. The mandible in prognathic girls tends to be positioned more anteriorly, resulting in a wider lower pharyngeal airway. (Angle Orthod. 2011;81:75-80.)

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  • Head motion may help mouth opening in children Reviewed

    K. Kuroda, I. Saitoh, E. Inada, Y. Takemoto, T. Iwasaki, Y. Iwase, C. Yamada, M. Shinkai, Y. Matsumoto, H. Hasegawa, Y. Yamasaki, H. Hayasaki

    ARCHIVES OF ORAL BIOLOGY   56 ( 1 )   102 - 107   2011.1

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    Concomitant head and mandibular movement during jaw function is well known in adults; however, its importance in children has not been studied. The brain attains 85-90% of its adult weight at 5 years of age, though the maximum rate of condylar growth is attained at approximately 14 years of age. These findings suggest that the coordination of the head and mandible may differ between children and adults. This study investigated head and mandibular movements of 19 children with complete primary dentition (average age: 5 years 5 months) and compared their functional integration of jaw and head movements to those of 16 female adults (average age: 20 years 3 months) with permanent dentition. Although the mandibular opening distance was significantly greater in the adults, the magnitude of concomitant head motion was greater in children. The results suggest that head extension in children helps increase the magnitude of mouth opening more than in adult women. (C) 2010 Elsevier Ltd. All rights reserved.

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  • Development of Labial-Closure Strength in Preschool Children. Reviewed

    Fukami A, Saitoh I, Iwase Y, Oku T, Inada E, Takemoto Y, Yamada C, Iwasaki T, Hasegawa H, Kubota N, Murakami T, Harada K, Nishi M, Kinjo S, Igata N, Hayasaki H, Yamasaki Y

    Journal of Craniomandibular Practice   28 ( 4 )   232 - 237   2010.10

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  • A Reproducibility Method to Test Lip-Closing Strength in Preschool Children Reviewed International journal

    Atsushi Fukami, Issei Saitoh, Emi Inada, Takeshi Oku, Yoko Iwase, Yoshihiko Takemoto, Chiaki Yamada, Tomonori Iwasaki, Hiroko Hasegawa, Naoko Kubota, Tomoya Murakami, Kanami Harada, Megumi Nishi, Sachiko Kinjo, Noriko Igata, Haruaki Hayasaki, Youichi Yamasaki

    CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE   28 ( 4 )   232 - 237   2010.10

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    This cross-sectional study tested the reproducibility of a simple button-pulling system for measuring lip-closing strength in normal preschool children and compared their strength to that of normal adults. The sample consisted of 348 preschool children and 123 adults. Lip-closing strength was measured by inserting a button, fastened to a piece of string, into the vestibule between the incisors and lips with minimal mouth opening. The string was attached to a digital tension gauge and was pulled parallel to the floor. Maximum tension, with three repetitions, was recorded at the instant that the button was pulled out of the mouth. Multilevel statistical models were used to evaluate any differences in contractive muscle strength between age groups and between the genders. The strength in children increased significantly from three years to five years (p&lt;0.01). Gender-related differences were found in adults but not in preschool children. Inter-individual variation at each age was larger than intra-individual variation. Measurement of lip-closing strength by button pulling is highly reproducible in children and has potential clinical and research applications.

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  • Is the reverse cycle during chewing abnormal in children with primary dentition?

    I. Saitoh, C. Yamada, H. Hayasaki, T. Maruyama, Y. Iwase, Y. Yamasaki

    Journal of Oral Rehabilitation   37   26 - 33   2010.1

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    The purpose of this study was to clarify whether the reverse cycle during chewing is abnormal in children with primary dentition. Children with normal primary dentition (N = 23; 5·5 ± 0·8 years) and female adults (N = 25; 20·7 ± 1·9 years) participated in this study. Chewing movement was recorded using an opto-electronic analysis system with six degrees-of-freedom (TRI-MET, Tokyo-shizaisha; Tokyo, Japan). Each subject was given a stick of chewing gum (new TRIDENT, WARNER-LAMBERT CO., Morris Plains, NJ, USA) and instructed to chew it normally. Starting from the maximum intercuspal position, each chewing sequence was recorded over a period of 20 s. A custom computer program identified individual chewing cycles. Frontal views were used to distinguish seven types of cycle shapes according to Ahlgren (Acta Odontol Scand, 24, 1966, 1-109; Acta Odontol Scand, 25, 1967, 3-13). Multilevel statistical models evaluated differences between children and adults. In the adults, type II cycles that initially opened towards the balancing side and then moved towards the working side were the most common, and the closing pathway was lateral to the opening pathway. In the children, type V (reverse) cycles that opened towards the working side were most common, the closing pathway was medial to the opening pathway, and there was a smaller lateral component during opening and closing than in adults (P &lt; 0·05). We conclude that the reverse cycle is not abnormal because normal children with primary dentition have a smaller lateral component and difficulty in controlling asymmetric muscle activity. © 2009 Blackwell Publishing Ltd.

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  • Jaw Motion During Gum-Chewing in Children with Primary Dentition Reviewed International journal

    Naoko Kubota, Haruaki Hayasaki, Issei Saitoh, Yoko Iwase, Tomoaki Maruyama, Emi Inada, Hiroko Hasegawa, Chiaki Yamada, Yoshihiko Takemoto, Yuko Matsumoto, Youichi Yamasaki

    CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE   28 ( 1 )   19 - 29   2010.1

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    This study was undertaken to characterize jaw motion during mastication in children with primary dentition and to compare jaw motion with that in adults. The means and the variances of the traditional parameters for the chewing cycle, i.e., duration, excursive ranges and 3-D distances of travel at the lower incisor, molars and condyles were analyzed and compared in 23 children and 25 female adults. The duration of opening in children was significantly shorter than that of adults. Significant differences between children and adults were observed in lateral and vertical excursion of the incisor, lateral excursion at the molars, and vertical excursion at the condyles. Many of these measurements had larger between-subject and between-cycle variances in children than adults, suggesting that chewing motion in children has not yet matured. The results of this study indicate that chewing motion in children is different from that of adults.

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  • Mandibular Open-Close Motion in Children with Anterior Crossbite Occlusion Reviewed International journal

    Junko Tokutomi, Haruaki Hayasaki, Issei Saitoh, Yoko Iwase, Atsushi Fukami, Chaiki Yamada, Yoshihiko Takemoto, Emi Inada, Youichi Yamasaki

    CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE   28 ( 1 )   10 - 18   2010.1

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    Anterior crossbite (ACB) malocclusions are frequent; however, its characteristic functional features have not been fully described. The purpose of this study was to determine the characteristics of habitual mandibular open-close motion in children with ACB of their primary dentition. Two groups of children were selected for study; 17 with ACB (eight boys and nine girls; four years one month to seven years one month) and 19 with normal occlusion (eight boys and 11 girls; four years six months to six years seven months). The motion was recorded using an optoelectronic analysis system with six degrees-of-freedom. Mandibular incisor and condylar motion were analyzed by measuring their three-dimensional ranges and trajectories. Also estimated incisor and condylar pathways of the two groups were compared. Patients with ACB opened wider with more anterior-posterior condylar translation and more mandibular rotation. Although between-subject (inter-individual) variance of all variables in children with ACB was larger, they had less within-subject variance at the condyles. These results indicate that open-close mandibular motion in children with ACB is completely different from that of children with normal occlusion. The different motions might be related to morphological differences between the two groups.

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  • Cephalometric Comparative Study of Pharyngeal Airway in Children with Prognathism and Normal Occlusion Reviewed

    Yoshihiko Takemoto, Issei Saitoh, Tomonori Iwasaki, Emi Inada, Chiaki Yamada, Yoko Iwase, Miyuki Shinkai, Ryuzo Kanomi, Haruaki Hayasaki, Youichi Yamasaki

    The Angle Orthodontist, June 19, 2010 (accepted).81(1):77-82, 2011   81 ( 1 )   77 - 82   2010.1

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  • Relationship of nasal and skeletal landmarks in lateral cephalograms of preschool children Reviewed International journal

    Emi Inada, Issei Saitoh, Haruaki Hayasaki, Yoko Iwase, Naoko Kubota, Yoshihiko Tokemoto, Chiaki Yamada, Youichi Yamasaki

    FORENSIC SCIENCE INTERNATIONAL   191 ( 1-3 )   111 - 111   2009.10

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    The purpose of this study was to investigate the relationship between cephalometric nasal and skeletal landmarks in preschool children. Lateral cephalograms of 80 Japanese preschool children (40 boys, mean age 5.4 +/- 0.3 years; 40 girls, mean age 5.2 +/- 0.1 years; total mean age 5.3 +/- 0.3 years) were traced, and 22 skeletal and 3 soft-tissue nasal points were digitized. The coordinates from each subject were transformed to a standardized plane using a custom-made program written in Microsoft Visual C++(R). In this standard plane, sella was the origin, Frankfort Horizontal (FH) plane was parallel to the X-axis, and all 25 points were rotated to match this reference plane. The three nasal landmarks used in this investigation were: (1) rhi&apos;, the intersection point of a line parallel to the FH plane at rhinion and the facial line; (2) pronasale (Prn), the most anterior point on the nose: and (3) subnasale (Sn), the most posterior-superior point where the columella met the upper lip. An independent-groups t-test was used to test for sex differences of coordinates of the nasal landmarks and their related skeletal landmarks. Significance was set at p &lt; 0.05. A stepwise regression analysis determined how combinations of skeletal landmarks explained the location of the nasal landmarks. Only one skeletal coordinate (N(X)) and no nasal coordinates showed a significant difference between boys and girls. The coordinates of rhi contributed significantly to the location of rhi&apos; and Prn (except for the Y-coordinate of girls). Moreover A-point and ANS contributed to the location of Prn and Sn. For Sn, the X- and Y-coordinates of girls and the Y-coordinate of boys were related to lower incisor or dentoalveolar structure of the mandible. It appears that the nasal landmarks in preschool children can be predicted from selected skeletal landmarks, and there are no sex differences for the nasal landmarks in children. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

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  • The P561T polymorphism of the growth hormone receptor gene has an inhibitory effect on mandibular growth in young children Reviewed International journal

    Yasunori Sasaki, Kyoko Satoh, Haruaki Hayasaki, Satoshi Fukumoto, Taku Fujiwara, Kazuaki Nonaka

    EUROPEAN JOURNAL OF ORTHODONTICS   31 ( 5 )   536 - 541   2009.10

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    Chi-square analysis showed that the frequency of this mutation did not differ statistically between the normal and mandibular protrusion subjects. Multilevel model analysis of the 101 cephalograms showed that the mutation reduced the linear measurements of the mandible. These findings suggest that P561T heterozygous mutation affects mandibular growth during early childhood, and this mutation in the GHR gene is hypothesized to function as an inhibitory factor in the process of mandibular growth.

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  • Oropharyngeal airway in children with Class III malocclusion evaluated by cone-beam computed tomography Reviewed International journal

    Tomonori Iwasaki, Haruaki Hayasaki, Yoshihiko Takemoto, Ryuzo Kanomi, Youichi Yamasaki

    AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS   136 ( 3 )   318.e1 - 318.e9   2009.9

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    Introduction: Upper airway size is increasingly recognized as an important factor in malocclusion. However, children with Class III malocclusion are somewhat neglected compared with those with a Class II skeletal pattern. Therefore, the purpose of this study was to establish the characteristic shape of the oropharyngeal airway (OA) in children with Class III malocclusion. Methods: The sample comprised 45 children (average age, 8.6 +/- 1.0 years) divided into 2 groups: 25 with Class I and 20 with Class III malocclusions. OA size of each group was evaluated by cone-beam computed tomography. Cluster analysis, based on OA shape, redivided the subjects into wide, square, and long types. The distributions of Class I and Class III subjects were compared among the types. Results: The Class III group showed statistically larger OA area and width compared with the Class I group. Area was positively correlated with Class III severity. The square type included 84% of the Class I malocclusions but only 30% of the Class III malocclusions, indicating that the OA in Class III malocclusion tends to be flat. Conclusions: The Class III malocclusion is associated with a large and flat OA compared with the Class I malocclusion. (Am J Orthod Dentofacial Orthop 2009;136:318.e1-318.e9)

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  • Dentigerous Cyst in Primary Dentition: Case Report of a 4-year-old Girl Reviewed

    Haruaki Hayasaki, Mayuko Ishibashi, Seiji Nakamura, Satoshi Fukumoto, Kazuaki Nonaka

    PEDIATRIC DENTISTRY   31 ( 4 )   294 - 297   2009.7

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    The purpose of this case report is to describe the treatment outcome of a 4-year-old girl with a dentigerous cyst on the primary mandibular right second premolar of her caries-free mouth. Her primary predecessor was extracted and the lesion decompressed by using a removable appliance with a resin projection. The succeeding premolar had not developed further 8 months later, however, and had to be extracted. Crown formation of the succeeding premolar might have been interrupted by the presence of the cyst. To our knowledge, this is the earliest reported asymptomatic dentigerous cyst in the mandibular premolar region with a vital primary second molar. (Pediatr Dent 2009;31:294-7) Received April 17, 2008 vertical bar Last Revision August 23, 2008 vertical bar Revision Accepted August 29, 2008

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  • Overlap of the primary dentition in children Reviewed International journal

    Issei Saitoh, Haruaki Hayasaki, Emi Inada, Tomoaki Maruyama, Yoshihiko Takemoto, Youichi Yamasaki

    Journal of Clinical Pediatric Dentistry   33 ( 3 )   269 - 274   2009.4

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    Objective: The aim of the present study was to estimate the amount of overlap in children with the primary dentition. Study design: The sample consisted of 20 Japanese boys between 3 and 5 years of age (mean age: 4years 10 months). Landmarks on their maxillary and mandibular dental models were digitized using a three-dimensional mechanical digitizer in a single coordinate system. Multilevel statistical models created best-fit polynomial curves to determine overbite, overjet and buccal height of all primary teeth and describe the dental arch forms. Results: No significant side differences were detected. The primary canine showed the largest overbite (1.87 mm) and buccal height (9.07 mm). The primary second molar exhibited the largest ovejet (2.76 mm). Buccal height was the least variable measurement. Conclusion: Occlusal relationships of the primary dentition were evaluated in 3-dimensions, establishing overlap variables for clinical diagnosis and treatment planning.

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  • A Cross-Sectional Study of Developing Resting Masseter Activity in Different Angle Classifications in Adolescence Reviewed International journal

    Kishio Sabashi, Issei Saitoh, Haruaki Hayasaki, Yoko Iwase, Suguru Kondo, Emi Inada, Yoshihiko Takemoto, Chiaki Yamada, Youichi Yamasaki

    CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE   27 ( 1 )   39 - 45   2009.1

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    The purpose of this study was to determine whether the development of masseter muscle activity at mandibular rest position is characteristic for different angle classifications. The sample consisted of 64 boys and 108 girls, aged ten to 18. Electromyographic (EMG) activity from the right and left masseter muscles was recorded using an EMG scanner. First or second order polynomials were used to separately model the age-related changes in resting muscle activity of each gender and Angle&apos;s classification. The EMG activity of Class I boys and girls were expressed in positive second order polynomials. The EMG activities of Class II and Class III subjects were expressed in first order polynomials, and the EMG levels in Class III subjects were lower than in Class II subjects. These results indicated that development of resting activity levels might distinguish and characterize the anteroposterior mandibular position relative to craniofacial region.

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  • Movement of the Instantaneous Center of Rotation and the Position of the Lateral Excursion Center During Lateral Excursion Reviewed International journal

    Haruaki Hayasaki, Issei Saitoh, Yoko Iwase, Emi Inada, Hiroko Hasegawa, Junko Tokutorm, Yuko Matsumoto, Youichi Yamasaki

    CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE   26 ( 4 )   255 - 264   2008.10

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    The instantaneous center of rotation has been used to describe sagittal plane kinematics of mandibular opening and closing. Although, lateral excursions are also important because the closing pathways of masticatory movements frequently coincide with those of lateral excursions with occlusal contacts, there are no similar descriptions of mandibular lateral excursions. To compensate for this deficiency, lateral excursions of 20 women were recorded in this study. Reference points around each subject's mandible were tracked in three dimensions for each 0.1 mm interval of 3-D distance traveled by the incisor during the first 6.0 mm of lateral excursion. ICR was represented by the point that traveled the least 3-D curvilinear distance during each interval. To describe the entire series of intervals, a lateral excursion center was represented by the point with the smallest 3-D curvilinear distance throughout the excursive movement. In the results of this study, lateral excursions can be described as rotation around a single fixed lateral excursion center that is located close to the intercondylar axis, but 22 mm posterior to the initial position of the working side condyle.

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  • Four-dimensional analysis of stomatognathic function Reviewed International journal

    Masahiko Terajima, Mizuki Endo, Yoshimitsu Aoki, Kyouko Yuuda, Haruaki Hayasaki, Tazuko K. Goto, Kenji Tokumori, Akihiko Nakasima

    AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS   134 ( 2 )   276 - 287   2008.8

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    Many researchers have attempted to clarify the complex relationships between stomatognathic function and craniofacial morphology. Most studies investigated the trajectories of incisal or condylar points and measured temporomandibular morphology projected onto 2-dimensional radiographic films. Although these methods provided valuable information, their diagnostic capabilities were limited. We introduce a new 4-dimensional (4D) analysis of stomatognathic function that combines the 3-dimensional (3D) computed tomography of the cranium and mandible, dental surface imaging with a noncontact 3D laser scanner, and mandibular movement data recorded with a 6 degrees of freedom jaw-movement analyzer. This method performs dynamic and precise simulations that can analyze and display condyle to fossa distances and occlusal contacts during mandibular function. These comprehensive relationships can be analyzed and displayed not only at intercuspal position, but also at any mandibular position during functional movements. We believe that our 4D analyzing system will be useful for diagnosing temporomandibular disorders of patients with jaw deformities and other malocclusions.

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  • Cross-sectional growth changes in skeletal and soft tissue cephalometric landmarks of children Reviewed International journal

    Emi Inada, Issei Saitoh, Haruaki Hayasaki, Chiaki Yamada, Yoko Iwase, Yoshihiko Takemoto, Yuko Matsumoto, Youichi Yamasaki

    CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE   26 ( 3 )   170 - 181   2008.7

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    In order to provide standard values for craniofacial growth of normal children, we evaluated the growth changes of skeletal and soft tissue cephalometric landmarks from lateral cephalograms of 180 Japanese children. They were divided into three groups: primary dentition, mixed dentition, and permanent dentition. Specific skeletal angles and distances showed significant gender differences with increasing age. The only significant soft tissue gender difference was nose height in the oldest group. Upper pharynx dimension and nose height differed significantly among the groups in both genders. Positions of both the upper and lower lip changed significantly between the intermediate and oldest groups of both genders. Nasolabial angle did not change significantly with growth. The results of this study should be useful for predicting craniofacial growth and development or determining the effect of orthodontic treatment.

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  • Four-dimensional visualization of mandibular movement using an individual's head model reconstructed from cephalograms Reviewed

    Kyouko Yuuda, Masahiko Terajima, Yoshimitsu Aoki, Haruaki Hayasaki, Akihiko Nakasima

    Orthodontic Waves   66 ( 4 )   113 - 121   2007.12

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    We introduce a new four-dimensional (4D) visualizing system of stomatognathic function that combines an individual's 3D head model, reconstructed from cephalograms, and mandibular movement data recorded with a six degrees-of-freedom jaw movement analyzer. The individual's head model was constructed by transforming a standard head model according to the 3D coordinate values calculated from the individual's cephalograms. The accuracy of the 3D reconstructed head model was determined. The error averaged 1.02%, with a range of 0.39-1.58%, and the accuracy was sufficient for clinical use. This method performs dynamic and precise simulation of mandibular movement. We believe that our system will be useful for evaluating the functional background of patients with malocclusions and maxillofacial deformities. © 2007 Elsevier Ltd and the Japanese Orthodontic Society.

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  • Correlations between incisor and condylar movements during lateral excursion in children with primary dentition

    I. Saitoh, J. Tokutomi, H. Hayasaki, Y. Iwase, H. Raoquig, Y. Yamasaki, K. Nonaka

    Journal of Oral Rehabilitation   34   800 - 806   2007.11

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    The purpose of this study was to look for associations between lower incisor movement and working and balancing condylar movement during lateral excursion in children with primary dentition and adults with permanent dentition. Mandibular movement was recorded using a TRI-MET (an optoelectronic analysis system with six degrees-of-freedom) at a sampling frequency of 100 Hz. The movement data was transferred to a graphics workstation for analysis. Subjects were categorized by age into two groups. The primary dentition group consisted of 19 children (mean age: 5 years and 5 months, s.d.: 8·7 months), and the permanent dentition group consisted of 22 women (mean age: 20 years and 5 months, s.d.: 26·3 months). The occlusion and TMJ in both groups were normal, with no history of orthodontic treatment. Three orthogonal excursive ranges and the 3D linear distance of the incisal and balancing and working condylar points, along with inter- and intra-individual correlations between the incisor and the balancing and working condyles during lateral excursion, were estimated by using multilevel statistical models. Lateral excursion in children with primary dentition was characterized by smaller incisor excursive ranges and 3D linear distance than in adults, and stronger inter- and intra-individual correlations between incisor and balancing condylar movements than in adults. In both children and adults the lateral excursion of the incisor was a good indicator of the extent of balancing condylar movement, but not working condylar movement. © 2007 Blackwell Publishing Ltd.

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  • Correlations between incisor and condyle motion during protrusion in children with primary dentition Reviewed International journal

    Issei Saitoh, Junko Tokutorni, Haruaki Hayasaki, Yoko Iwase, Huang Raoquig, Youichi Yamasaki, Kazuaki Nonaka

    CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE   25 ( 2 )   90 - 97   2007.4

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    The purpose of this study was to investigate the relationship between incisor and condyle movement during protrusion in children with primary dentition. Subjects were categorized into two age groups. A primary dentition group consisted of 20 children, and a permanent dentition group consisted of 25 women. The occlusion and TMJ in both groups were normal, with no history of orthodontic treatment. Three orthogonal excursive ranges, linear distance and curvilinear distance of the incisal and condylar points; sagittal angle of condylar rotation; and correlations between incisor and condyle distances during protrusion were estimated by using multilevel statistical models. Protrusion in children with primary dentition was characterized by: 1. significantly smaller superior-inferior ranges for incisal and condylar points in children than in adults; 2. strong positive correlations between incisor and condylar anterior-posterior ranges and linear distances, a pattern similar to that in adults.

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  • A new way of analyzing occlusion 3 dimensionally Reviewed International journal

    H Hayasaki, RP Martins, LG Gandini, Saitoh, I, K Nonaka

    AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS   128 ( 1 )   128 - 132   2005.7

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    This article introduces a new method for 3-dimensional dental cast analysis, by using a mechanical 3-dimensional digitizer, MicroScribe 3DX (immersion, San Jose, Calif and TIGARO software (not yet released, but available from the author at hayasaki@dent.kyushu-u.ac.jp). By digitizing points on the model, multiple measurements can be made, including tooth dimensions; arch length, width, and perimeter; curve of Spee; overjet and overbite; and anteroposterior discrepancy. The bias of the system can be evaluated by comparing the distance between 2 points as determined by the new system and as measured with digital calipers. Fifteen pairs of models were measured digitally and manually, and the bias was evaluated by comparing the variances of both methods and checking for the type of error obtained by each method. No systematic errors were found. The results showed that the method is accurate, and it can be applied to both clinical practice and research.

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  • Incisal paths during habitual mouth opening and closing movements of children with anterior reverse bite in the early mixed dentition Reviewed International journal

    K Satoh, Y Yamasaki, H Hayasaki, M Nishi, M Nakata

    CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE   22 ( 4 )   289 - 296   2004.10

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    The purpose of this study was to investigate whether the pathways of habitual mouth opening and closing in children with anterior reverse bit-e in the early mixed dentition differed from those of children with normal occlusion. The two subject groups for this study were composed of ten children with anterior reverse bite (reverse bite group) and twelve children with normal occlusion (normal occlusion group), respectively. These movements were measured by an optoelectronic analyzing system with six degrees of freedom. Movements of the incisal point were projected on the sagittal plane to characterize the paths, and sagittal angles between the incisal path and the horizontal plane were calculated and compared. Opening and closing sagittal angles in the reverse bite group were almost equal over the entire pathway, indicating that the pathways of habitual mouth opening and closing were similar. In contrast, all opening and closing sagittal angles in the normal occlusion group were different, especially close to maximum intercuspation, indicating that their pathway of habitual mouth opening differed from their mouth closing pathway. In conclusion, children with anterior reverse bite in the early mixed dentition have different patterns of habitual mouth opening and closing movements than children with normal occlusion.

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  • Characteristics of the gum chewing occlusal phase in children with primary dentition

    Saitoh, I, H Hayasaki, S Nakata, Y Iwase, M Nakata

    JOURNAL OF ORAL REHABILITATION   31 ( 5 )   406 - 411   2004.5

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    Understanding of the growth and development of mandibular function is indispensable to the diagnosis of functional disturbances during childhood. The purpose of this study was to clarify the characteristics of the occlusal phase during gum chewing in children with primary dentition. Chewing motion at the working molar of 14 children with primary dentition and 28 female adults was recorded optoelectrically, and the frontal and sagittal angles of their closing and following opening strokes were measured and compared. In children the closing strokes were entered more vertically and anteriorly than in adults, and the opening strokes shifted to the non-working side in adults but moved to the working side in children. The degree of variance also differed between the two groups; the variance of the frontal angle was larger than that of sagittal angle in adults, but the opposite was true in children. These results suggested that the chewing pattern in children during the occlusal phase is distinctly different from adults and the chewing movement in children is not always less stable than in adults.

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  • Masticatory motion after surgical or nonsurgical treatment for unilateral fractures of the mandibular condylar process Reviewed International journal

    GS Throckmorton, E Ellis, H Hayasaki

    JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY   62 ( 2 )   127 - 138   2004.2

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    Purpose: We sought to compare mandibular motion during mastication in patients treated in either an open or a closed fashion for unilateral fractures of the mandibular condylar process.
    Patients and Methods: Eighty-one male patients with unilateral condylar process fractures were treated either with (n = 37) or without (n = 44) surgical reduction and rigid fixation of their condylar process fractures. At 6 weeks, 6 months, 1 year, and 2 years after treatment, the subjects' chewing cycles were recorded using a magnetic sensor array (Sirognathograph; Siemens Corp, Bensheim, Germany) while chewing Gummi-Bears (HARIBO, Bonn, Germany) unilaterally on the same side as the fracture and on the opposite side. The chewing cycles were analyzed using a custom computer program, and the duration, excursive ranges, and 3-dimensional cycle shape were compared between the 2 treatment groups at each time interval using multilevel linear modeling statistics.
    Results: The 2 treatment groups did not differ significantly for any measure of cycle duration or any excursive range (except lateral excursions at 1 year post-treatment) at any of the time intervals. However, the 3-dimensional cycle shapes of the 2 groups did differ significantly at all time intervals.
    Conclusion: Surgical correction of unilateral condylar process fractures has relatively little effect on the more standard measures (duration and excursive ranges) of masticatory function. However, surgical correction better normalizes opening incisor pathways during mastication on the side opposite the fracture. (C) 2004 American Association of Oral and Maxillofacial Surgeons.

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  • Occlusal contact area of mandibular teeth during lateral excursion Reviewed

    H Hayasaki, A Okamoto, Y Iwase, Y Yamasaki, M Nakata

    INTERNATIONAL JOURNAL OF PROSTHODONTICS   17 ( 1 )   72 - 76   2004.1

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    Purpose: This study observed occlusal contacts and determined their areas on the mandibular teeth, especially the molars, during voluntary lateral excursions. Materials and Methods: Occlusal contact areas were estimated with a measurement system combining 3-D tracking of mandibular movements with 3-D digitization of tooth shape. Sixteen women with sound permanent dentitions participated. Results: At the intercuspal position, estimated occlusal contact areas of the first and second mandibular molars were on average 12.6 mm(2) and 9.0 mm(2), respectively. However, after 3.0 mm of lateral excursion, their areas were sharply reduced to 2.2 mm(2) and 1.5 mm(2) on the working side, and 0.4 mm(2) and 1.1 mm(2) on the nonworking side, respectively. Conclusion: These results suggest that the occlusal contact areas on working- and nonworking-side molars differ from each other as lateral excursion proceeds.

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  • Jaw kinematics during mastication after unilateral fractures of the mandibular condylar process Reviewed International journal

    GS Throckmorton, E Ellis, H Hayasaki

    AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS   124 ( 6 )   695 - 707   2003.12

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    This study compared the mandibular kinematics during mastication of patients treated for unilateral fractures of the mandibular condylar process with those of control subjects. We used a Sirognathograph (Siemens, Bensheim, Germany) to record the chewing cycles of 81 male patients with unilateral condylar process fractures while they chewed a constant bolus unilaterally on the same side as the fracture and on the opposite side. Recordings were made at 6 weeks, 6 months, 1 year, and 2 years after treatment. Similar chewing cycles were recorded for 15 male controls (Class I dental and Class I skeletal occlusion) without fractures of the condylar process. The chewing cycles of both groups were analyzed with a custom computer program, and the duration, excursive ranges, and 3-dimensional cycle shape were compared at each time interval with multilevel linear modeling statistics. Fracture patients had significantly slower chewing cycles, with significantly less maximum excursion toward the working side during the closing phase and significantly greater excursion toward the balancing side during the opening phase than the controls. The opening pathway of the incisors showed greater differences between patients and controls than the closing pathways. Differences in chewing cycle shape persisted for up to 2 years, especially when chewing was on the side opposite the fracture. Unilateral condylar process fractures produce long-lasting changes in chewing cycle duration and chewing cycle shape of adults.

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  • Length of the occlusal glide during chewing in children with primary dentition

    H Hayasaki, T Sawami, Saitoh, I, Y Iwase, S Nakata, M Nakata

    JOURNAL OF ORAL REHABILITATION   30 ( 11 )   1138 - 1141   2003.11

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    Chewing is one of the most important functions of the mandible, but, to date, there are very few studies of this function in children. The purpose of this study was to quantify the length of the occlusal glide at the lower incisal point during gum chewing in children with primary dentition. Eleven girls with primary dentition were selected for this study. Mandibular excursions with occlusal contacts and gum chewing movement were measured using an optoelectronic system that can measure mandibular movement with six degrees-of-freedom at a sampling frequency of 100 Hz. A curved mesh diagram of incisor coordinates during mandibular excursions was established to calculate the length of the occlusal glide for each subject. The occlusal glide lengths of children were compared with previously reported results for adults. The estimated length of the occlusal glide during closing was significantly shorter in children than in adults, contrary to that during opening. This result suggests that children have a characteristic chewing pattern that differs from adults.

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  • Occlusal phase of gum-chewing strokes Reviewed

    H Hayasaki, Saitoh, I, GS Throckmorton, Y Iwase, S Nakata, M Nakata

    JOURNAL OF ORAL REHABILITATION   30 ( 10 )   1041 - 1046   2003.10

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    The occlusal phase of chewing is especially interesting because food particles are being pulverized in this phase. For efficient chewing the upper and lower teeth must come together in a congruent fashion with less variation than in other phases. To examine this expectation the chewing motions of 28 women were recorded optoelectrically, and their frontal and sagittal angles of the closing and following opening strokes were measured at 3.0 mm ( 3- D linear distance) of opening. Closing strokes were more stable than opening strokes. The frontal angle was correlated with the sagittal angle during closing. The opening and closing sagittal angles were moderately correlated, and the opening and closing frontal angles were negatively correlated at the intersubject level. No direct association was found between the closing strokes and following opening strokes at the intra- subject level. These results suggest that closing strokes are more stable than opening strokes, resulting in efficient mastication.

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  • Alveolar bone loss associated with glucose tolerance in Japanese men Reviewed

    T Marugame, H Hayasaki, K Lee, H Eguchi, S Matsumoto

    DIABETIC MEDICINE   20 ( 9 )   746 - 751   2003.9

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    Aims Type 2 diabetes is known to affect alveolar bone loss (ABL). The purpose of this study was to examine whether impaired glucose tolerance (IGT) is associated with ABL, as is diabetes.
    Methods A case-control study was performed with 664 Japanese men aged 46-57 years. Panoramic radiographs revealed 513 severe ABL cases, 22 moderate ABL cases, and 129 controls with good alveolar bone. Diabetes status was classified into normal glucose tolerance (NGT), impaired fasting glucose (IFG), IGT, and newly diagnosed diabetes according to the fasting plasma glucose and 75-g oral glucose tolerance test (OGTT). Diabetes under treatment was excluded. Odds ratios (ORs) and 95% confidence intervals (CIs) were obtained from ordinal logistic regression analysis. Statistical adjustment was made for total cholesterol, HDL-cholesterol, triglyceride, rank in the Self Defence Forces (SDF), cigarette-years, alcohol use, body mass index, previous 10 years' brushing habits and instrument use other than toothbrush, and history of periodontal treatment.
    Results A significant, approximately three-fold increase in the crude OR (crude OR = 3.28; 95% CI = 1.16-9.27) and non-significant 2.6-fold increase in the adjusted OR (adjusted OR = 2.55; 95% CI = 0.86, 7.54) of ABL was observed among men with newly diagnosed Type 2 diabetes compared with the reference group (NGT combined with IFG). However, there was no association between IGT and ABL (adjusted OR = 0.99; 95% CI = 0.59,1.64).
    Conclusions Type 2 diabetes, but not IGT, was positively associated with ABL. Preventive maintenance against periodontitis is important in middle-aged men with diabetes.

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  • Longitudinal observation of basic mandibular movements: Report of a case Reviewed

    H. Hayasaki, A. Okamoto, S. Nakata, Y. Yamasaki, M. Nakata

    Journal of Clinical Pediatric Dentistry   27 ( 4 )   333 - 337   2003

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    Sound development of mandibular function during childhood is indispensable to establishing healthy function in adults. To examine this developmental process, longitudinal recordings of basic mandibular movements were done using an optoelectronic analysis. Mandibular movements were recorded on five separate occasions in one boy, from an age of six years and five months to 14 years and five months. The incisor pathways during protrusion and lateral excursion were initially shallow, with more anterior than inferior movement, but as he grew the amount of inferior movement and the amount of rotation both increased. Similarly, at his first recording there was very little hinge-like rotation during mouth closing, but rotation increased markedly after eruption of his permanent second molars. These findings suggest that mandibular movements change from being relatively simple with more translation in younger children to more complex movements with more rotation once the permanent dentition is established.

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  • Length of the occlusal glide at the lower incisal point during chewing Reviewed

    H Hayasaki, T Sawami, Saitoh, I, S Nakata, Y Yamasaki, M Nakata

    JOURNAL OF ORAL REHABILITATION   29 ( 11 )   1120 - 1125   2002.11

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    The purpose of this study was to estimate the length of the occlusal glide during gum chewing at the lower incisal point. Mandibular excursions with occlusal contacts in 25 females with permanent dentition were recorded using an optoelectronic system that can measure mandibular movement with 6 d.f. at a sampling frequency of 100 Hz. A curved mesh diagram of incisor coordinates during maximum mandibular excursions (CMDME) was plotted. Gum chewing movement was also measured using the same system and computer software which divided the chewing movement into cycles at each maximum opening position. Each cycle was standardized at 0.1 mm intervals from the most closed position. Finally, the distance between the CMDME and each position of the incisor during a chewing cycle was calculated. Whenever, this distance was less than 0.2 mm opposing teeth were considered to be in contact. The occlusal glide was defined as the distance travelled by the lower incisal point as the mandible moved along occlusal contacts of the CMDME. The vertical coordinates at the beginning of the occlusal glide (during closing) and at the end of occlusal glide (during opening) were also calculated. The lengths of the occlusal glide pathway averaged 1.29 mm during closing and 1.55 mm during opening, a total length of 2.84 mm. Mean vertical coordinates at the beginning and end of the glide were -0.95 and -1.12 mm from inter-cuspal position, respectively.

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  • Position and Variability of Minimum Opening Position during Gum-chewing

    HAYASAKI Haruaki, NAKATA Shiho, SAITOH Issei, IWASE Yoko, NAKATA Minoru

    Prosthodont Res. Pract.   1 ( 1 )   66 - 73   2002.10

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    <b><i>Purpose</i> : </b>Determining the minimum opening position during chewing when food particles are being fractured and the variability of this minimum opening, which also affects the efficiency of the motion, are crucial for dentistry. This paper investigated estimates of the minimum opening position during gum-chewing movements and compared the variability of different mandibular reference points (i.e., lower incisal point, right and left molars). The variability between the maximum intercuspal position and the minimum opening position was also compared.<br><b><i>Materials and Methods</i> : </b>Twenty-eight young female subjects participated in this study. The gum-chewing motion of each subject was recorded using an optoelectronic analysis system with six degree-of-freedom. Minimum opening position was defined as the position where the lower incisal point reached its uppermost position between two maximum opening positions.<br><b><i>Results</i> : </b>The three reference points at the minimum opening position were located more posteriorly compared with their position at the maximum intercuspal position. The minimum opening position of the molars was more stable than that of the lower incisal point, and the molar had less variability on the working side than on the balancing side. In the lateral direction, the mandibular position at the maximum intercuspal position was less stable than at the minimum opening position during chewing.<br><b><i>Conclusion</i> : </b>The minimum opening position was not coincident with the maximum intercuspal position. In addition, its reproducibility was relatively higher than the maximum intercuspal position, especially in the lateral direction, suggesting that closer attention must be paid to lateral deviation of bite registration at the maximum intercuspal position.

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  • The effects of bolus hardness on masticatory kinematics Reviewed

    K Anderson, GS Throckmorton, PH Buschang, H Hayasaki

    JOURNAL OF ORAL REHABILITATION   29 ( 7 )   689 - 696   2002.7

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    This study investigated how jaw kinematics, including cycle duration, three-dimensional (3-D) excursive ranges and velocities, and cycle shape, changed with increasing hardness of chewing gum. Twenty-six subjects (13 males and 13 females; mean age 23.6 +/- 2.5 years) with Class I normal occlusion were asked to chew two brands of gum with differing hardness. Jaw motion during chewing was tracked with an Optotrak(R) camera at 100 Hz, and all movements were recorded as pure 3-D mandibular movements relative to Frankfort horizontal. Cycle duration did not change significantly with harder gum, but 3-D excursive ranges and velocities increased, except during the occlusal phases of the chewing. Cycle shape was similar for hard and soft gum, but the overall size of the cycle was larger with hard gum. These results suggest that greater muscular effort when chewing harder gum produces a greater acceleration of the mandible in all phases except when the harder gum slows the mandible during the occlusal phases.

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  • Condylar motion in children with primary dentition during lateral excursion Reviewed International journal

    Y Yamasaki, H Hayasaki, M Nishi, S Nakata, M Nakata

    CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE   20 ( 3 )   172 - 180   2002.7

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    Normal development of primary and mixed dentition is indispensable for establishing a healthy mandibular function of the permanent dentition. Because condylar movements are crucial for mandibular function, extensive studies have been reported. However, most of these studies have dealt with mandibular functions in adults, and there is less known about children with primary dentition. The purpose of this study was to clarify the condylar movements during lateral excursions in children with primary dentition and compare these movements with those of adults from the viewpoint of functional development. With use of an optoelectronic recording system with six degrees of freedom, the lateral excursions of 24 children and 20 young women, with sound dentition, were recorded at 100 Hz. The results show that the balancing side condyle of the children had a significantly smaller vertical excursion and a significantly larger anteroposterior excursion than that of adults, indicating the shallower and more anteriorly directed movements of the entire mandible during lateral excursions in children with primary dentition.

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  • Improvement in jaw motion following treatment of unilateral crossbite in a child with primary dentition: A case report Reviewed International journal

    Saitoh, I, H Hayasaki, Y Iwase, M Nakata

    CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE   20 ( 2 )   129 - 134   2002.4

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    This case report examines jaw motion during both habitual opening-closing and gum chewing in a young (3 years, 10 months) patient with unilateral crossbite at the primary dentition stage. Jaw motion was measured three times: 1. before treatment; 2. after active treatment; and 3. after retention. The abnormal habitual open-close pathway seen prior to treatment was improved after retention. Prior to treatment, movement of the affected-side condyle preceded movement of the non-affected-side condyle during opening. After retention, the movement of the condyles was better coordinated. The chopping type chewing pattern, with less lateral movement, before treatment changed to a more grinding type pattern on the affected side after activation. This study suggests that the prescribed treatment effectively improved both the patient's morphology and function. However, neither the open-close pathways nor the chewing patterns were completely normal after retention. The results in this case suggest that early treatment of functional unilateral crossbite can be effective.

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  • Incisal and condylar paths during habitual mouth opening movement of children with anterior reverse bite in the primary dentition Reviewed

    M Nagata, Y Yamasaki, H Hayasaki, M Nakata

    JOURNAL OF ORAL REHABILITATION   29 ( 1 )   64 - 71   2002.1

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    The purpose of this study was to evaluate whether the path of habitual mouth opening was influenced by anterior reverse bite malocclusion in children. Two groups of children with the primary dentition were chosen: (i) 10 children with anterior reverse bite (reverse bite group) and (ii) 10 with normal occlusion (normal occlusion group). Their habitual mouth opening movements were measured by an opto-electronic movement-analysing system with 6 d.f. at a sampling rate of 100 Hz. These movements were projected on the sagittal plane at the incisal and condylar points. To characterize the path, we used the angles between the path and the horizontal plane. in the initial stage of opening, the incisal path of the reverse bite group was displaced more posteriorly from the intercuspal position than that of the normal occlusion group. However, as opening continued, the direction of the path of the reverse bite group was more anterior than those of the normal occlusion group. During the entire opening movement, the condylar path of the reverse bite group was flatter than those of the normal occlusion group. in conclusion, it was demonstrated that anterior reverse bite in the primary dentition clearly affects the paths of habitual opening movements.

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  • Changes in the masticatory cycle following treatment of posterior unilateral crossbite in children Reviewed

    GS Throckmorton, PH Buschang, H Hayasaki, AS Pinto

    AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS   120 ( 5 )   521 - 529   2001.11

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    In a previous study, we established that young children with unilateral posterior crossbite have a longer mandibular ramus and more superiorly and posteriorly positioned condyles on the crossbite side. In this study, we evaluated chewing cycle shape and duration in 14 of the patients before treatment, and we looked for changes in cycle shape and duration 6 months after treatment with rapid palatal expansion. Mandibular kinematics was recorded while chewing gum using an optoelectric recording system at 100 Hz. Subjects were asked to chew normally for 20 cycles, chew on the crossbite side only for 20 cycles; and chew on the noncrossbite side only for 20 cycles. A special computer program selected the 10 most representative cycles from each series and computed an average duration and an average maximum excursion along 3 orthogonal axes. Multilevel linear models were used to generate an 8th-order polynomial describing average cycle shape and to test for statistically significant differences in shape between the patients and the controls and between the patients before and after treatment. Before treatment, the patients chewed more slowly than did the controls. Treatment shortened their cycle duration to equal control values. Before treatment, the patients also had larger maximum excursions than did the controls and exhibited a reverse-sequence cycle shape when chewing on the crossbite side. Treatment did not alter the patients' abnormal cycle shape: These results suggest that some features of the masticatory kinematics respond to orthodontic treatment alone, but others do not.

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  • Translation and rotation of the mandible during habitual mouth opening movement in children with anterior reverse bite in the primary dentition Reviewed

    M Nagata, Y Yamasaki, H Hayasaki, M Nakata

    CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE   19 ( 2 )   96 - 105   2001.4

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    Translation and rotation of the mandible during habitual mouth opening movements were studied in 13 children with skeletal-based anterior reverse bite (reverse bite group) and in 13 children with normal occlusion (normal occlusion group) whose dental stage was the primary dentition. Movements were recorded by an opto-electronic movement-analyzing system that could measure mandibular movements with six degrees of freedom. Inferior translation of the mandible was analyzed at the left primary central incisor, both of the primary canines, and both of the primary second molars. Anterior translation of the mandible was analyzed at both of the condyles. Rotation of the mandible was measured in the sagittal plane. The results showed that the associations between the translation and rotation of the mandible during habitual mouth opening in the reverse bite group differed from those in the normal occlusion group. The reverse bite group had greater anterior translation of both of the condylar points than did the normal occlusion group. No significant differences were found in the inferior translation or rotation of the mandible between the two groups.

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  • The effects of chewing rates on mandibular kinematics Reviewed

    GS Throckmorton, BH Buschang, H Hayasaki, T Phelan

    JOURNAL OF ORAL REHABILITATION   28 ( 4 )   328 - 334   2001.4

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    The purpose of this study is to provide basic understanding of how the speed of chewing affects masticatory jaw kinematics. Twenty-six healthy subjects (23.6 +/- 2.5 years of age) chewed a standardized bolus of gum at fast (100 cycles s(-1)), habitual and slow (50 cycles s(-1)) rates. The rates were controlled with a metronome and the order of rates was randomized for each subject. An optoelectrical system independently recorded head and jaw movement. Special computer programs identified representative cycles for each subject and computed various aspects of jaw movement. Multilevel statistical procedures were used to compare cycle variables among the three rates, estimate variability and model jaw movements. Maximum ranges of anteroposterior (AP), vertical and lateral jaw excursions were significantly less for the fast than the habitual or slow rates. While the shape of 3-D pathway was similar for the three rates, the perimeter of the pathway was significantly shorter for fast chewing cycles. Maximum AP, vertical, lateral and total 3-D jaw velocities were significantly different among the three rates. Between cycle variation in cycle duration and jaw excursion were least during fast chewing and the greatest during slow chewing; variability in maximum velocity was similar for the three rates.

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  • Incisor and mandibular condylar movements of young adult females during maximum protrusion and lateratrusion of the jaw Reviewed

    PH Buschang, GS Throkmorton, KH Travers, H Hayasaki

    ARCHIVES OF ORAL BIOLOGY   46 ( 1 )   39 - 48   2001.1

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    This study evaluated the correlations between condylar translation and incisor movements during maximum protrusion and lateratrusion. The sample was 27 adult females (23-35 years old), selected for normal temporomandibular function, occlusion, and skeletal patterns. Condylar and mandibular central incisor movements [linear distances (LD) and curvilinear pathways (CP)] were recorded in three dimensions for 20 s with an optoelectric (Optotrak(R)) jaw-tracking system while each participant performed multiple maximum protrusive and lateratrusive cycles. Masticatory analysis and multilevel statistical programs computed the three-dimensional movements of the incisors and condylar hinge axis during protrusion and lateratrusion, CP of the incisor point averaged 12.0 mm (9.3 mm LD) during protrusion, 13.0 mm (11.5 mm LD) during right excursion and 12.3 mm (11.0 mm LD) during left excursion. CP Of the condyles averaged 11.9-12.9 (9.2-9.5 LD) mm during protrusion. During lateratrusion the contralateral condyles moved anteroinferiorly 11.6-14.1 mm (9.5-10.2 mm LD); the ipsilateral condyles moved posterolaterally 5.8-6.8 mm (2.3-2.5 mm LD). The left condyles demonstrated more movement than the right condyles during protrusion and than the contralateral condyles during laterotrusion. Relative variation, as measured by the coefficient of variation, was greater for the movements of the ipsilateral than contralateral condyles. Incisor movements were only moderately related to condylar movements between individuals and between replicates; LDs showed stronger correlations than CPs; and correlations were stronger for lateratrusion than protrusion. While incisor and condylar movements were not affected by repeated protrusion, incisor CP (approx. 0.2 mm/cycle) and LD (approx. 0.1 mm/cycle) increased significantly with repeated excursive movements to the left and right. It was concluded that (1) incisor protrusion and lateratrusion provide moderately reliable measures of condylar translation: (2) the linear distances that the incisors move during lateratrusion provide the best measure of contralateral condylar translation: and (3) condylar movements are not affected by repeated protrusion or lateratrusion. (C) 2000 Elsevier Science Ltd. All rights reserved.

    DOI: 10.1016/S0003-9969(00)00096-0

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  • Difference in tracks between habitual open and close mandibular movements at the condyle in children Reviewed

    N Nishijima, H Hayasaki, A Okamoto, S Nakata, Y Yamasaki, M Nakata

    JOURNAL OF ORAL REHABILITATION   27 ( 11 )   999 - 1003   2000.11

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    Although previous studies have paid much attention to the condylar movement in adults with permanent dentition, little attention has been paid to such movement in children. In this study, we therefore clarified the difference in habitual open and close movements at the condyle in children . Three groups of subjects were used; primary (10 children), early mixed (10 children), and permanent dentition (10 adults). The habitual open and close mandibular movement of each subject was measured using a TRIMET, which can three-dimensionally analyse the simultaneous movements of multiple points on the mandible of a subject. The measurements were then compared among the three groups. The three-dimensional analysis detected significant difference in all directions between children with primary dentition and adults with permanent dentition: primary dentition had the smallest anterior-posterior and superior-inferior directions, and the largest left-right direction. Coincidence of the open and close tracks occurred in the adults (adult group) but not in the children (primary and early-mixed dentition groups). The early-mixed dentition group showed tracks that were between those for the primary dentition group and the adult group. These results suggest that the regularity of the condylar track might be well established with dental development.

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  • Occlusal contacts during lateral excursions in children with primary dentition. Reviewed

    Okamoto A, Hayasaki H, Nishijima N, Iwase Y, Yamasaki Y, Nakata M

    J Dent Res   79 ( 11 )   1138 - 1141   2000.11

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  • Occlusal contacts during lateral excursions in children with primary dentition Reviewed

    A Okamoto, H Hayasaki, N Nishijima, Y Iwase, Y Yamasaki, M Nakata

    JOURNAL OF DENTAL RESEARCH   79 ( 11 )   1890 - 1895   2000.11

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    The presence of non-working occlusal contacts in adults is considered abnormal and may initiate parafunctional activity. Few studies have looked for non-working occlusal contacts in children with primary: dentition. The purposes of this study were (1) to prove the existence of non-working-side occlusal contacts, and (2) to quantify their area during lateral excursion in children with primary dentition. To achieve this purpose, wt developed a measurement system that combined II tracking system for mandibular movements with a three-dimensional digitizer for tooth shape. Ten children were selected for this study. Estimated occlusal contact area of the primary second molar on the non-working side was 0.8 mm(2), in contrast to 2.0 mm(2) on the working side, at 3.0 mm of movement of the lower incisor. All children examined had some occlusal contacts on the non-working side during the first part of lateral excursion.

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  • Quantification of human chewing-cycle kinematics Reviewed

    PH Buschang, H Hayasaki, GS Throckmorton

    ARCHIVES OF ORAL BIOLOGY   45 ( 6 )   461 - 474   2000.6

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    This study introduces new methods of quantifying and evaluating the human chewing cycle. These methods were validated on a sample of 26 young adults (11 women and 15 men) between 20-35 years of age. Movements of the mandibular central incisors were recorded (100 Hz) using an optoelectric computer system while the participants chewed gum. A subsample of 10 cycles was automatically selected, based on multiple objective criteria to ensure representative cycles for each individual. Once representative cycles had been identified, multilevel statistical models were used to evaluate and describe the sample's kinematic patterns. The multilevel procedures allow for missing observations, they do not assume equal intervals. and variation can be partitioned hierarchically. Two-level models showed significantly shorter cycle duration for males (835 msec) than females (973 msec). Inferior-superior (IS) cycle range was 2.6 mm larger and maximum LS velocity was 19.6 mm/sec faster in males than females. There were no significant differences in medial-lateral (ML) and anteroposterior (AP) excursive ranges or velocities. With the exception of cycle duration and ML ranges of motion, random variation was three to five times larger between individuals than between cycles. The three-level models showed that eighth-order polynomials were necessary to describe IS, AP, and ML chewing movements of the entire cycle. The models identified highly significant sex differences in cycle kinematics (excursions, velocities, accelerations, etc.) for each aspect of movement (AP, IS, and ML). It is concluded that this;approach provides several important advantages over existing methods, including (a) its objectivity, (b) a more complete description of kinematic patterns, (c) a hierarchical description of variation, and (d) its ability to test hypotheses statistically, (C) 2000 Elsevier Science Ltd. All rights reserved.

    DOI: 10.1016/S0003-9969(00)00015-7

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  • Associations between incisor and mandibular condylar movements during maximum mouth opening in humans Reviewed

    KH Travers, PH Buschang, H Hayasaki, GS Throckmorton

    ARCHIVES OF ORAL BIOLOGY   45 ( 4 )   267 - 275   2000.4

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    This study evaluated the common clinical assumption that condylar translation and mouth opening at the incisor are closely related. The sample studied comprised 27 adult females (23-35 years), selected for normal temporomandibular function, occlusion, and skeletal patterns. Condylar and mandibular central incisor movements (straight-line distances and curvilinear pathways) were recorded in three dimensions (3D) for 20 s with an optoelectric (Optotrak(R)) jaw-tracking system while each participant performed multiple maximum opening cycles. Masticatory analysis and multilevel statistical programs computed the 3D movements of the incisors and condylar hinge axis during opening and closing. The incisor point moved an average straight-line distance of 46.6 mm during opening and 45.9 mm during closing, the lengths of the opening and closing curvilinear pathways were 48.6 and 47.7 mm, respectively. The condyles moved average straight-line distances of 11.9 and 12.2 mm during opening and closing, respectively. The condyles' curvilinear pathways during opening and closing were 14 and 14.6 mm, respectively. Ranges of condylar movement varied widely between individuals. The straight-line distances and curvilinear pathways were highly correlated for the incisors (R = 0.98) and the condyles (R = 0.98). Neither the straight-line distances nor curvilinear pathways of the incisors were correlated with those of the condyles. Incisor straight-line distances and curvilinear pathways were moderately correlated with mandibular rotation (R-between (subjects) = 0.82 and R-between (repeats) = 0.88) During repeated openings, both condylar and incisor excursions increased, but during repeated closings only incisor excursions increased. It is concluded that (1) maximum incisor opening does not provide reliable information about condylar translation and its use as a diagnostic indicator of condylar movement should be limited, (2) healthy individuals may perform normal opening with highly variable amounts of condylar translation, (3) the straight-line distances of the incisor and condyles provide adequate information about the length of the curvilinear pathway, and (4) variation in maximum incisor opening is largely explained by variation in the amount of mandibular rotation. (C) 2000 Elsevier Science Ltd. All rights reserved.

    DOI: 10.1016/S0003-9969(99)00140-5

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  • A calculation method for the range of occluding phase at the lower incisal point during chewing movements using the curved mesh diagram of mandibular excursion (CMDME) Reviewed

    H Hayasaki, S Nakata, N Nishijima, A Okamoto, K Minematsu, Y Yamasaki, M Nakata

    JOURNAL OF ORAL REHABILITATION   26 ( 3 )   236 - 242   1999.3

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    The purpose of this study was to develop a method for calculating the range of the occluding phase in chewing movements. In this study, we defined 'range' as the distance of the movement at the lower incisal point while the mandible moves with tooth contact. First, mandibular excursions were measured using an opto-electronic movement analysis system, which can measure mandibular movement with six degrees-of-freedom at a sampling frequency of 100 Hz. With use of this measurement data, the curved mesh diagram of mandibular excursion (CMDME) previously reported was made. Then, chewing movements were measured using the same analysis system. The movements were separated into their component chewing cycles. Finally, we calculated the distance between each cycle and the CMDME. The occluding range of our subject was 0.4 mm at the closing phase and 3.4 mm at the opening phase. These results suggest that tooth contact occurs during chewing movement and demonstrate that the range of the occluding phase for the opening and closing phases of a subject can be calculated without morphological data from a dental cast.

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  • CMDME (curved mesh diagram of mandibular excursion) method for visualization and diagnosis of mandibular movement Reviewed

    H Hayasaki, S Nakata, N Nishijima, A Okamoto, K Minematsu, Y Yamasaki, M Nakata

    JOURNAL OF ORAL REHABILITATION   25 ( 9 )   672 - 676   1998.9

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    The CMDME (curved mesh diagram of mandibular excursion) method was developed for easy visualization and diagnosis of mandibular movement. This method uses measured mandibular movement to produce a diagram of the range, shape, and inclination of mandibular excursion in three dimensions using any arbitrary landmark of the mandible. First, the mandibular movement of a subject was measured by an opto-electronic movement analysis system capable of measuring mandibular movement with six degrees-of-freedom at a sampling frequency of 100 Hz. For the measurement, the subject was initially instructed to perform four repetitions of mandibular excursion at will, with tooth contact, each lasting 30 s. A total of 12 000 positions of the mandible were thus obtained. Secondly, an attempt was made to match these positions to intersection points (0.1 mm apart) of a CMDME (i.e. mesh) for arbitrary mandibular landmarks with intercuspal position at the origin. The CMDME method can visualize mandibular excursion, and can be used to compare several landmarks, different subjects, or different times. This makes this method an effective diagnostic tool for mandibular movement.

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  • Characteristics of protrusive and lateral excursions of the mandible in children with the primary dentition Reviewed

    H Hayasaki, Y Yamasaki, N Nishijima, K Naruse, M Nakata

    JOURNAL OF ORAL REHABILITATION   25 ( 4 )   311 - 320   1998.4

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    This study characterizes the mandibular protrusive and lateral excursions of children with primary dentition. With use of a Selspot(R) system, the protrusive and lateral excursions of nine children with the primary dentition and nine adults with the permanent dentition were measured and compared. This system was able to analyse the simultaneous movements of multiple points on the mandible of a subject in three dimensions. Furthermore, the system proved appropriate for use in young children because of the small burden imposed on them during the measurements. Using this subject-friendly system, the directions of the mandibular excursion for five reference points on the mandibular dental arch at each measurement distance (i.e. at 0.5 mm intervals) for three projected angles (frontal, sagittal and horizontal) were calculated. From the results it was found that the excursions of the primary dentition can move more horizontally and more forward with small descent compared with the permanent dentition. The underlying reason for these findings may be physiological growth, maturation, and adaptation of the occlusal function.

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  • 小児の下顎前方滑走運動に関する研究

    早崎治明, 山崎要一, 中田 稔

    小児歯科学雑誌   29 ( 2 )   379 - 388   1991

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    複数の下顎任意点について三次元的に同時解析が可能な下顎多点運動解析システムを用いて,ヘルマンの歯年齢2A(男児3名,女児6名),3A(男児2名,女児7名)の小児,および成人(男9名)の前方滑走運動を計測し解析を加えた.歯年齢2Aおよび3Aの小児では,成人より矢状面投影角が有意に小さく,下方への動きが少なく浅い運動をしていた.前頭面投影角は歯年齢2A,3A,成人と順次大きくなり,前方滑走時の左右への偏位が減少していた.また,歯年齢2Aの矢状面投影角では,オーバーバイト,オーバージェットと有意な正の相関が認められたが,歯年齢3Aでは,水平面投影角とオーバージェットの間で負の相関が見られ,オーバージェットが下顎の左右への偏位を規制していると考えられた.歯年齢3Aは,歯年齢2Aと成人の移行型と思われる運動をしていた

    DOI: 10.11411/jspd1963.29.2_379

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=1991&ichushi_jid=J00647&link_issn=&doc_id=19870146610011&doc_link_id=10.11411%2Fjspd1963.29.2_379&url=https%3A%2F%2Fdoi.org%2F10.11411%2Fjspd1963.29.2_379&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

  • 埋伏歯の三次元的認識に関する研究

    阿部和久, 山﨑要一, 田中武昌, 緒方哲朗, 早崎治明, 中田 稔

    小児歯科学雑誌   29 ( 3 )   569 - 575   1991

  • 当科における咬合に異常がみられた患児の実態調査

    山崎桂子, 廣田和子, 山﨑要一, 野中和明, 早崎治明, 阿部和久, 中田 稔

    小児歯科学雑誌   27 ( 2 )   522 - 528   1989

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    築野沙絵子, 中村由紀, 中島努, 花崎美華, 笹川祐輝, 朴沢美生, 五月女哲也, 米本裕貴, 早崎治明

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    船山 ひろみ, 齊藤 桂子, 森川 和政, 仲野 和彦, 飯沼 光生, 清水 武彦, 下村 淳子[黒木], 馬場 篤子, 内川 喜盛, 島田 幸恵, 齊藤 正人, 倉重 圭史, 福田 敦史, 八若 保孝, 島村 和宏, 早崎 治明, 大島 邦子, 関本 恒夫, 大須賀 直人, 星野 倫範, 新谷 誠康, 辻野 啓一郎, 苅部 洋行, 白川 哲夫, 岩本 勉, 宮新 美智世, 船津 敬弘, 木本 茂成, 浅里 仁, 守安 克也, 長谷川 信乃, 大川 玲奈, 有田 憲司, 原田 京子, 香西 克之, 岩本 優子, 仲野 道代, 平野 慶子, 北村 尚正, 牧 憲司, 山座 治義, 尾崎 正雄, 藤原 卓, 山崎 要一, 村上 大輔, 朝田 芳信

    小児歯科学雑誌   59 ( 2 )   80 - 94   2021.6

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    教育問題検討委員会では、全国29歯科大学・大学歯学部の小児歯科学の講義を担当する講座を対象に、平成30年度版歯科医師国家試験出題基準の小児歯科学分野における必修の基本事項、歯科医学総論および各論の大・中・小項目の内容に関してのアンケート調査を行った。調査の結果、現状の必修および歯科医学総論の出題基準には、少なからず問題のあることがわかった。歯科医学各論に関しては、必修や総論に比べ、より具体性の高い出題基準になっていることが窺われた。必修・歯科医学総論および各論において、各々の小項目の記載がない中項目(以下、中項目とする)および小項目が小児歯科学分野の国家試験出題基準に該当するかの問いに対しては、「該当する」との回答が50%未満の中項目あるいは小項目が50%以上を占める大項目が多数認められた。(著者抄録)

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  • 口唇閉鎖を伴う3種被験運動における複合センサーを用いた口腔機能評価

    朴沢 美生, 中村 由紀, 中島 努, 笹川 祐輝, 築野 沙絵子, 五月女 哲也, 岩瀬 陽子, 齋藤 一誠, 早崎 治明

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    笹川 祐輝, 中村 由紀, 中島 努, 築野 沙絵子, 朴沢 美生, 五月女 哲也, 岩瀬 陽子, 齊藤 一誠, 早崎 治明

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    野上 有紀子, 齊藤 一誠, 岩瀬 陽子, 中村 由紀, 早崎 治明

    新潟歯学会雑誌   50 ( 2 )   105 - 106   2020.12

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  • 【乳歯・永久歯の萠出時期についての考察】日本人小児における乳歯・永久歯の萠出時期に関する調査研究(II)

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    現在の日本人小児の乳歯と永久歯の萠出時期、萠出順序、第一大臼歯と中切歯の萠出パターンを明らかにするとともに、1988年に小児歯科学会が行った前回調査結果と比較することで、日本人の乳歯・永久歯の萠出に変化が生じているか否かについて検討した。前回調査に準じた方法で全国的調査が行われ、調査対象児は、歯の萠出時期に影響を及ぼし、歯種判定困難、萠出判定困難に関連する全身疾患を有するものを除外し、乳歯に関しては生後3ヵ月から47ヵ月(3歳11ヵ月)、永久歯に関しては4歳0ヵ月から18歳11ヵ月の健常な日本人小児39549人とした。乳歯の分析対象は0〜3歳(男児4404人、女児4320人)、永久歯の分析対象は4〜18歳(男子15308人、女子15517人)であった。最初に萠出する乳歯である下顎乳中切歯の萠出時期が男児は6.8ヵ月(前回調査では8.0ヵ月)、女児は7.5ヵ月(前回調査では9.0ヵ月)と有意に早くなっていた永久歯の平均萠出年齢に関しては、前回調査と比較すると、男子では上下顎の第一小臼歯、第二小臼歯、第一大臼歯で本調査結果の方が有意に遅かった。乳歯の萠出時期のばらつきに関しては、標準偏差を比較すると、男児では全ての歯種に、女児では上顎乳側切歯を除き全ての歯種に今回調査が前回調査より大きい値を示した。萠出時期の最小-最大月齢の幅は、下顎の第一乳臼歯と第二乳臼歯を除いて男児より女児の方が小さかった。日本人の乳歯の萠出は前回調査より個人差が拡大している傾向がうかがわれた。また、永久歯の萠出時期のばらつきも大きくなっている傾向が明らかとなった。

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  • 小児のスプーンを用いた捕食時口唇圧に食品の差異が及ぼす影響

    笹川 祐輝, 中村 由紀, 中島 努, 築野 沙絵子, 朴沢 美生, 五月女 哲也, 岩瀬 陽子, 齋藤 一誠, 早崎 治明

    小児歯科学雑誌   58 ( 大会抄録(誌上開催)号 )   99 - 99   2020.4

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  • スプーンを用いた捕食動作におけるスプーンの位置・姿勢と口唇圧の同時分析

    櫻井 隆佑, 林 豊彦, 中村 由紀, 中島 努, 早崎 治明

    日本顎口腔機能学会雑誌   26 ( 2 )   120 - 121   2020.3

  • 当院小児歯科・障がい者歯科診療室における初診患者の実態調査

    小野寺 早紀, 岩瀬 陽子, 清川 裕貴, 五月女 哲也, 朴沢 美生, 笹川 祐輝, 中島 努, 中村 由紀, 齊藤 一誠, 早崎 治明

    小児歯科学雑誌   58 ( 地方会抄録号 )   4 - 4   2020.2

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  • マイクロパターン化した魚うろこコラーゲン足場材を用いた培養口腔粘膜の開発

    鈴木 絢子, 干川 絵美, 羽賀 健太, 塩見 晶, 上野山 敦士, 齊藤 一誠, 早崎 治明, 泉 健次

    新潟歯学会雑誌   49 ( 2 )   76 - 76   2019.12

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  • 全身麻酔下歯科治療前後の口腔衛生指導によってセルフケア意識の向上を認めたADHD患者の1症例

    平原 三貴子, 岩瀬 陽子, 村上 智哉, 黒澤 美絵, 野上 有紀子, 近藤 淳子, 倉田 行伸, 弦巻 立, 瀬尾 憲司, 早崎 治明

    障害者歯科   40 ( 3 )   349 - 349   2019.9

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  • ATR-X症候群の男児における口腔管理の1例

    中村 由紀, 野上 有紀子, 森岡 沙耶香, 小野寺 早紀, 中島 努, 黒澤 美絵, 岩瀬 陽子, 大島 邦子, 齊藤 一誠, 早崎 治明

    障害者歯科   40 ( 3 )   303 - 303   2019.9

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  • 日本人小児における乳歯・永久歯の萠出時期に関する調査研究(その2) 永久歯について

    有田 憲司, 阿部 洋子, 仲野 和彦, 齊藤 正人, 島村 和宏, 大須賀 直人, 清水 武彦, 尾崎 正雄, 石通 宏行, 松村 誠士, 石谷 徳人, 濱田 義彦, 渥美 信子, 小平 裕恵, 高風 亜由美, 長谷川 大子, 林 文子, 藤岡 万里, 茂木 瑞穂, 八若 保孝, 田中 光郎, 福本 敏, 早崎 治明, 関本 恒夫, 渡部 茂, 新谷 誠康, 井上 美津子, 白川 哲夫, 宮新 美智世, 苅部 洋行, 朝田 芳信, 木本 茂成, 福田 理, 飯沼 光生, 仲野 道代, 香西 克之, 岩本 勉, 野中 和明, 牧 憲司, 藤原 卓, 山崎 要一

    小児歯科学雑誌   57 ( 3 )   363 - 373   2019.6

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    日本人永久歯の萠出時期、萠出順序および第一大臼歯と中切歯の萠出パターンを明らかにし、約30年前と比べて永久歯の萠出に変化があるか否かを検討する目的で、4歳0ヵ月から18歳11ヵ月の小児30,825人を調査し、以下の結果を得た。1.男子の萠出は、1が5歳6ヵ月-7歳0ヵ月、6が5歳10ヵ月-7歳6ヵ月、1が6歳6ヵ月-7歳10ヵ月、2が6歳3ヵ月-8歳3ヵ月、6が5歳11ヵ月-8歳7ヵ月、2が7歳6ヵ月-9歳2ヵ月、3が9歳2ヵ月-11歳3ヵ月、4が9歳1ヵ月-11歳7ヵ月、4が9歳5ヵ月-11歳6ヵ月、3が9歳10ヵ月-12歳1ヵ月、5が10歳4ヵ月-13歳0ヵ月、5が10歳3ヵ月-13歳2ヵ月、7が11歳3ヵ月-13歳10ヵ月、7が12歳1ヵ月-14歳5ヵ月の順であった。2.女子の萠出は、1が5歳5ヵ月-6歳7ヵ月、6が5歳6ヵ月-7歳0ヵ月、1が6歳3ヵ月-7歳7ヵ月、2が6歳3ヵ月-7歳8ヵ月、6が5歳10ヵ月-8歳4ヵ月、2が7歳2ヵ月-8歳8ヵ月、3が8歳8ヵ月-10歳5ヵ月、4が8歳11ヵ月-11歳0ヵ月、4が9歳1ヵ月-11歳1ヵ月、3が9歳2ヵ月-11歳4ヵ月、5が10歳1ヵ月-12歳11ヵ月、5が10歳2ヵ月-13歳1ヵ月、7が11歳2ヵ月-13歳10ヵ月、7が11歳9ヵ月-14歳3ヵ月の順であった。3.萠出順序は、男女ともに上顎が6≒1→2→4→3→5→7で、下顎が1→6→2→3→4→5→7であった。4.第一大臼歯と中切歯の萠出パターンは、男子では上顎がM型77.2%、I型22.8%で、下顎がM型29.2%、I型70.8%であった。女子では上顎がM型73.4%、I型26.6%で、下顎がM型36.7%、I型63.3%であった。5.萠出時期の性差は、すべての歯種で女子が早く萠出しており、上下顎1、2、3、4および6に有意差が認められた。6.約30年前に比べて、男子は上下顎4、5、6が、女子は3、上下顎の4、5、6、7の萠出時期が有意に遅くなっていた。(著者抄録)

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  • 歯根切除が歯の再植・移植後の歯髄歯根膜治癒過程に及ぼす影響について

    大島 邦子, 早崎 治明, 大島 勇人

    小児歯科学雑誌   57 ( 2 )   234 - 234   2019.5

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  • 未就学児における口呼吸症候群に関連する因子の探索的研究

    稲田 絵美, 齊藤 一誠, 海原 康孝, 村上 大輔, 野上 有紀子, 窪田 直子, 白澤 良執, 奥 猛志, 早崎 治明, 山崎 要一

    小児歯科学雑誌   57 ( 2 )   261 - 261   2019.5

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  • ヒト乳歯由来歯髄細胞における繰り返しの初期化因子遺伝子導入はiPS細胞形成能を増強した多能性中間細胞を生成する

    齊藤 一誠, 稲田 絵美, 村上 智哉, 岩瀬 陽子, 黒澤 美絵, 清川 裕貴, 窪田 直子, 山崎 要一, 早崎 治明, 佐藤 正宏

    小児歯科学雑誌   57 ( 2 )   214 - 214   2019.5

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  • 若年者における口呼吸症候群に関連する因子探索に関する基礎研究

    海原 康孝, 齊藤 一誠, 稲田 絵美, 村上 大輔, 野上 有紀子, 窪田 直子, 早崎 治明, 山崎 要一, 石川 隆義

    小児歯科学雑誌   57 ( 2 )   313 - 313   2019.5

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  • 小児の口唇閉鎖力のトレーニング効果に影響を与える因子

    野上 有紀子, 齊藤 一誠, 稲田 絵美, 海原 康孝, 村上 大輔, 窪田 直子, 岩瀬 陽子, 黒澤 美絵, 中島 努, 山崎 要一, 早崎 治明

    小児歯科学雑誌   57 ( 2 )   267 - 267   2019.5

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  • 乳歯列期における咬合治療を通した軟組織形態と咀嚼機能の評価

    黒澤 美絵, 齊藤 一誠, 中島 努, 野上 有紀子, 笹川 祐輝, 築野 沙絵子, 岩瀬 陽子, 早崎 治明

    小児歯科学雑誌   57 ( 2 )   314 - 314   2019.5

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  • モーションキャプチャシステムを用いたスプーンによる捕食動作の多角的解析

    笹川 祐輝, 中村 由紀, 中島 努, 築野 沙絵子, 齋藤 一誠, 早崎 治明, 櫻井 隆佑, 林 豊彦

    小児歯科学雑誌   57 ( 1 )   103 - 103   2019.2

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  • 日本人小児における乳歯・永久歯の萠出時期に関する調査研究II(その1.) 乳歯について

    有田 憲司, 阿部 洋子, 仲野 和彦, 齊藤 正人, 島村 和宏, 大須賀 直人, 清水 武彦, 石通 宏行, 松村 誠士, 尾崎 正雄, 石谷 徳人, 濱田 義彦, 渥美 信子, 小平 裕恵, 高風 亜由美, 長谷川 大子, 林 文子, 藤岡 万里, 茂木 瑞穂, 八若 保孝, 田中 光郎, 福本 敏, 早崎 治明, 関本 恒夫, 渡部 茂, 新谷 誠康, 井上 美津子, 白川 哲夫, 宮新 美智世, 苅部 洋行, 朝田 芳信, 木本 茂成, 福田 理, 飯沼 光生, 仲野 道代, 香西 克之, 岩本 勉, 野中 和明, 牧 憲司, 藤原 卓, 山崎 要一

    小児歯科学雑誌   57 ( 1 )   45 - 53   2019.2

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    日本人乳歯の萠出時期および萠出順序を明らかにし、乳歯の萠出に変化が生じているか否かを検討する目的で、全国的に3ヵ月から3歳11ヵ月の小児8,724名を調査し、以下の結果を得た。1.男児の乳歯萠出は、下顎乳中切歯が5ヵ月-9ヵ月、上顎乳中切歯が7ヵ月-11ヵ月、上顎乳側切歯が9ヵ月-1歳2ヵ月、下顎乳側切歯が9ヵ月-1歳3ヵ月、下顎第一乳臼歯が1歳1ヵ月-1歳6ヵ月、上顎第一乳臼歯が1歳1ヵ月-1歳7ヵ月、上顎乳犬歯が1歳2ヵ月-1歳8ヵ月、下顎乳犬歯が1歳2ヵ月-1歳9ヵ月、下顎第二乳臼歯が1歳11ヵ月-2歳7ヵ月、上顎第二乳臼歯が2歳0ヵ月-2歳11ヵ月の順だったが、上顎乳側切歯・下顎乳側切歯間と下顎第一乳臼歯、上顎第一乳臼歯、上顎乳犬歯および下顎乳犬歯の間には有意な差は認められなかった。2.女児の乳歯萠出は、下顎乳中切歯が6ヵ月-9ヵ月、上顎乳中切歯が7ヵ月-11ヵ月、上顎乳側切歯が9ヵ月-1歳1ヵ月、下顎乳側切歯が9ヵ月-1歳2ヵ月、上顎第一乳臼歯が1歳1ヵ月-1歳7ヵ月、下顎第一乳臼歯が1歳1ヵ月-1歳7ヵ月、上顎乳犬歯が1歳3ヵ月-1歳9ヵ月、下顎乳犬歯が1歳4ヵ月-1歳9ヵ月、下顎第二乳臼歯が1歳11ヵ月-2歳7ヵ月、上顎第二乳臼歯が2歳1ヵ月-2歳10ヵ月の順だったが、下顎乳中切歯、上顎乳中切歯間、上顎乳中切歯・上顎乳側切歯間、上顎乳側切歯・下顎乳側切歯間、下顎第一乳臼歯・上顎第一乳臼歯間、上顎乳犬歯・下顎乳犬歯間には有意な差は認められなかった。3.性差は大部分の歯で認めず、上顎乳犬歯と下顎乳犬歯の萠出時期にのみ有意な差を認め、いずれも男児が1ヵ月早く萠出していた。4.前回報告(1988年)に比べて、男児は上顎乳中切歯、下顎乳中切歯、下顎乳犬歯、下顎第一乳臼歯の、女児は下顎乳中切歯と下顎第一乳臼歯の、萠出時期が有意に早くなっていることを認めた。(著者抄録)

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  • 口蓋床の形状が口蓋裂児の吸啜に及ぼす影響

    松原 まなみ, 落合 聡, 中村 由紀, 早崎 治明

    日本口蓋裂学会雑誌   43 ( 3 )   209 - 215   2018.10

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    健常乳児の口蓋には吸啜窩が存在し、吸啜時に乳首を固定して哺乳を円滑にする役割を果たしている。口蓋裂児の哺乳機能を補うために口蓋床を装着する治療が行われるが、我々は口蓋裂児の口蓋形態を可能な限り健常児に近づけることで吸啜運動が活発になり効果的な吸啜が出来るようになるのではないかと仮説を立て、口蓋床に吸啜窩を付与するという改良を試みた。本研究の目的は口唇口蓋裂児の哺乳が円滑になることを目指し、従来の口蓋床(従来型)に吸啜窩を付与する(改良型)ことが吸啜時の舌運動に与える影響を検証することである。対象は口唇口蓋裂以外に吸啜力に影響を及ぼす病態のない口唇口蓋裂児8例で、口蓋裂児6例、口唇顎裂児2例であった。従来型と吸啜窩を付与した改良型で哺乳瓶哺乳を行い、超音波診断装置を用いて吸啜時の舌運動をB-modeで撮影した。解析にはDITECT社製、動画解析プログラム(DippMotionPro)を使用した。画像の舌表面に8ヶ所の計測点を設けて経時的に追尾させ、連続で得られた10吸啜波形について、各点の変位量と吸啜周期を計測し、吸啜窩付与前後で比較した。舌の総変位量は吸啜窩付与前・後で平均23.4±0.9mmから24.7±2.3mmへ増加した。吸啜窩付与により吸啜周期は0.78±0.04sから0.82±0.02sへ延長し、吸啜周期は安定した。改良型口蓋床で舌の変位量が増加したことから、口蓋床に吸啜窩を付与することは哺乳効率の向上に寄与する可能性が示唆された。(著者抄録)

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  • 介助磨きの姿勢は歯磨き運動に影響するか(第2報) 一般成人の動作解析

    大島 邦子, 野上 有紀子, 村井 朋代, 丸山 直美, 中島 努, 花崎 美華, 早崎 治明

    障害者歯科   39 ( 3 )   308 - 308   2018.9

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  • 気管支喘息による慢性咳嗽のため全身麻酔管理に苦慮したダウン症候群患者の一例

    金丸 博子, 倉田 行伸, 岸本 直隆, 田中 裕, 弦巻 立, 中村 由紀, 早崎 治明, 瀬尾 憲司

    障害者歯科   39 ( 3 )   348 - 348   2018.9

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  • 日本小児歯科学会主催教育ワークショップの実施 大学間のバリエーションの把握

    八若 保孝, 内川 喜盛, 香西 克之, 飯沼 光生, 早崎 治明, 清水 武彦, 佐藤 昌史, 中村 光一, 木本 茂成

    日本歯科医学教育学会総会・学術大会プログラム・抄録集   37回   126 - 126   2018.7

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  • 介助磨きの姿勢に関する検討―歯磨き運動と歯垢除去効果―

    村井朋代, 村井朋代, 大島邦子, 野上有紀子, 花崎美華, 中島努, 丸山直美, 早崎治明

    障害者歯科   39 ( 2 )   110‐118 - 118   2018.6

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  • 初期胚特異的糖鎖抗原SSEA‐1は乳歯歯髄細胞由来iPS細胞の高度未分化状態を特定するマーカーとして有用である

    稲田絵美, 齊藤一誠, 窪田直子, 村上智哉, 澤味規, 松枝一成, 早崎治明, 山崎要一

    小児歯科学雑誌   56 ( 2 )   214 - 214   2018.4

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  • 小児の咬合面の成長変化に関する研究

    齊藤一誠, 澤味規, 野上有紀子, 稲田絵美, 海原康孝, 村上大輔, 岩瀬陽子, 辻井利弥, 香西克之, 山崎要一, 早崎治明

    小児歯科学雑誌   56 ( 2 )   268 - 268   2018.4

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  • Evidence Based Dentistry in Pediatric Dentistry(9)卒乳について

    中島努, 中村由紀, 平原三貴子, 笹川祐輝, 小野寺早紀, 齊藤一誠, 早崎治明

    小児歯科学雑誌   56 ( 1 )   93 - 93   2018.2

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  • 減汗型外胚葉異形成症患児に対し早期から継続的な口腔衛生管理に携わった1例

    近藤淳子, 森岡沙耶香, 野上有紀子, 大島邦子, 早崎治明

    小児歯科学雑誌   56 ( 1 )   101 - 101   2018.2

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  • これからの小児歯科と医療連携

    早崎治明

    日本小児外科学会雑誌   54 ( 3 )   527(J‐STAGE) - 527   2018

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  • 魚のうろこコラーゲンを足場に利用した培養口腔粘膜の開発

    鈴木絢子, 鈴木絢子, 加藤寛子, 加藤寛子, 干川絵美, 塩見晶, 上野山敦士, 河上貴宏, 兒玉泰洋, 齋藤一誠, 早崎治明, 泉健次

    日本再生医療学会総会(Web)   17th   2018

  • リプログラミング因子の一過的強制発現は乳歯培養歯髄細胞の幹細胞化を誘導し,その多分化能を増強させる

    左右田美樹, 齊藤一誠, 村上智哉, 松枝一成, 岩瀬陽子, 澤味規, 大島勇人, 早崎治明

    新潟歯学会雑誌   47 ( 2 )   122 - 122   2017.12

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  • 介助磨きの姿勢は歯みがき運動と歯垢除去効果に影響する

    村井朋代, 村井朋代, 大島邦子, 野上有紀子, 花崎美華, 中島努, 丸山直美, 丸山直美, 早崎治明

    新潟歯学会雑誌   47 ( 2 )   124 - 124   2017.12

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  • Development of the evaluation system of occlusal plane in children

    君雅水, 齊藤一誠, 澤味規, 野上有紀子, 岩瀬陽子, 黒澤美絵, 中村由紀, 中島努, 早崎治明

    新潟歯学会雑誌   47 ( 2 )   81‐86 - 86   2017.12

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  • 光学式3次元動作測定装置を用いた浸潤麻酔時における動作解析

    中村太, 佐藤拓実, 早崎治明, 奥村暢旦, 藤井規孝, 藤井規孝

    新潟歯学会雑誌   47 ( 2 )   123 - 123   2017.12

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  • 刷掃指導の効果・三次元動作と歯垢除去効果の解析―

    丸山直美, 丸山直美, 大島邦子, 村上朋代, 村上朋代, 中島努, 花崎美華, 野上有紀子, 早崎治明

    新潟歯学会雑誌   47 ( 2 )   115 - 115   2017.12

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  • Dental Treatment for Persons with Disabilities at Pediatric Medical Center

    鹿児島暁子, 中村由紀, 花崎美華, 村上望, 澤味規, 松枝一成, 鈴木絢子, 左右田美樹, 中島努, 野上有紀子, 君雅水, 村上智哉, 黒澤美絵, 岩瀬陽子, 大島邦子, 齊藤一誠, 早崎治明

    小児歯科学雑誌   55 ( 4 )   442‐450 - 450   2017.11

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  • うろこコラーゲンを使用した培養口腔粘膜の開発

    鈴木絢子, 鈴木絢子, 加藤寛子, 加藤寛子, 干川絵美, 塩見晶, 河上貴宏, 兒玉泰洋, 齋藤一誠, 早崎治明, 泉健次

    日本バイオマテリアル学会大会予稿集(Web)   39th   97 (WEB ONLY) - 97   2017.11

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  • 介助磨きの姿勢はブラッシング運動に影響するか

    村井朋代, 村井朋代, 大島邦子, 野上有紀子, 花崎美華, 中島努, 丸山直美, 丸山直美, 近藤淳子, 森岡沙耶香, 早崎治明

    障害者歯科   38 ( 3 )   354 - 354   2017.9

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  • 臨床の基礎編―後編~無痛治療を目指す~乳歯抜歯の技と注意点

    岩瀬陽子, 早崎治明

    月刊小児歯科臨床   22 ( 8 )   27‐35 - 35   2017.8

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  • 光学式3次元動作解析装置を用いた浸潤麻酔時における動作解析

    中村太, 佐藤拓実, 林豊彦, 中島努, 早崎治明, 佐藤直子, 昆はるか, 奥村暢旦, 藤井規孝, 藤井規孝

    日本歯科医学教育学会総会・学術大会プログラム・抄録集   36th   116 - 116   2017.7

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  • VICONシステムを用いた1級インレー窩洞形成動作の解析

    佐藤拓実, 中村太, 林豊彦, 中島努, 早崎治明, 佐藤直子, 昆はるか, 小野高裕, 奥村暢旦, 藤井規孝, 藤井規孝

    日本歯科医学教育学会総会・学術大会プログラム・抄録集   36th   117 - 117   2017.7

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  • 日本小児歯科学会主催CBT問題作成ワークショップの実施

    八若保孝, 内川喜盛, 香西克之, 早崎治明, 飯沼光生, 清水武彦, 佐藤昌史, 藤原卓, 新谷誠康, 中村光一, 高橋千尋, 木本茂成

    日本歯科医学教育学会総会・学術大会プログラム・抄録集   36th   151 - 151   2017.7

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  • 日本小児歯科学会主催CBT問題作成ワークショップの実施

    八若 保孝, 内川 喜盛, 香西 克之, 早崎 治明, 飯沼 光生, 清水 武彦, 佐藤 昌史, 藤原 卓, 新谷 誠康, 中村 光一, 高崎 千尋, 木本 茂成

    日本歯科医学教育学会総会・学術大会プログラム・抄録集   36回   151 - 151   2017.7

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  • 全国実態調査からみた永久歯先天性欠如の現状

    山崎要一, 岩崎智憲, 稲田絵美, 佐藤秀夫, 早崎治明, 齊藤一誠

    成育歯科医療研究会会誌   13 ( 1 )   5‐14 - 14   2017.6

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  • 小児の歯の外傷 小児歯科学雑誌の掲載報告と診療ガイドライン

    中村 由紀, 齊藤 一誠, 倉重 圭史, 鈴木 淳司, 星野 倫範, 島村 和宏, 飯沼 光生, 早崎 治明, 齊藤 正人, 日本小児歯科学会臨床研究推進委員会

    小児歯科学雑誌   55 ( 3 )   331 - 344   2017.6

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    小児歯科臨床において、乳歯および幼若永久歯の外傷を主訴として来院する患者の割合が近年増加しているという報告がある。歯の外傷については、日本小児歯科学会発足当初から頻繁に研究課題としてとりあげられ、これまでに小児歯科学会雑誌に掲載された学会発表抄録は270編、総説・論文等は57編である。国外では、2012年にThe International Association of Dental Traumatology(IADT)が三編からなる診療ガイドラインを作成し、刊行誌であるDental Traumatologyに掲載した。これを受け2013年に、American Academy of Pediatric Dentistry(AAPD)は、その刊行誌であるPediatric DentistryにIADTの診療ガイドラインをAAPDの歯の診療ガイドラインとしてそのまま掲載した。そこで本稿では、日本小児歯科学会における歯の外傷に関するこれまでの報告等について集成し、診療ガイドライン作成の背景や意義を踏まえて検討するとともに、今後の方向性について考察を行った。(著者抄録)

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  • お口ぽかん(口唇閉鎖不全症)と口呼吸症候群のエビデンスと臨床

    齊藤一誠, 早崎治明

    Quintessence   36 ( 5 )   0952‐0976 - 0976   2017.5

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  • 口腔機能,お口あそびからのアプローチ 現代っ子の口腔機能は大丈夫?

    齊藤一誠, 早崎治明

    月刊小児歯科臨床   22 ( 5 )   6‐15 - 15   2017.5

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  • 【小児をとりまく最近の臨床トピックス】 (TOPIC 3)小児の食・口の機能とその異常

    中村 由紀, 齊藤 一誠, 早崎 治明

    日本歯科評論   77 ( 5 )   53 - 58   2017.5

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  • 非牽引での上顎水平埋伏中切歯の萌出誘導―乳歯外傷後Perにより歯胚位置異常が進行したと思われる1例―

    齊藤一誠, 岩瀬陽子, 村上望, 村上智哉, 早崎治明

    小児歯科学雑誌   55 ( 2 )   275 - 275   2017.4

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  • 我が国の口呼吸症候群小児は増加傾向にあるのか?

    野上有紀子, 齊藤一誠, 稲田絵美, 海原康孝, 村上大輔, 窪田直子, 岩瀬陽子, 香西克之, 山崎要一, 早崎治明

    小児歯科学雑誌   55 ( 2 )   267 - 267   2017.4

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  • 遺伝子工学的手法による不死化ヒト乳歯歯髄細胞株の樹立と特性解析

    稲田絵美, 齊藤一誠, 窪田直子, 村上智哉, 左右田美樹, 澤味規, 松枝一成, 早崎治明, 山崎要一

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  • 血管迷走神経性失神を繰り返す小児における歯科治療時の行動調整と循環動態

    岩瀬陽子, 鹿児島暁子, 野上有紀子, 大島邦子, 中村由紀, 齊藤一誠, 早崎治明

    小児歯科学雑誌   55 ( 2 )   201 - 201   2017.4

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  • エックス線CT画像による正中過剰埋伏歯の三次元画像解析方法の検討

    中村由紀, 星野倫範, 星野倫範, 梶美奈子, 島村和宏, 島村和宏, 佐野正之, 佐野正之, 齊藤一誠, 早崎治明, 齊藤正人, 齊藤正人

    小児歯科学雑誌   55 ( 2 )   252 - 252   2017.4

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  • 未就学小児における三次元顔面軟組織の年齢間比較に関する形態学的研究

    辻井利弥, 稲田絵美, 村上大輔, 齊藤一誠, 海原康孝, 野上有紀子, 窪田直子, 白澤良執, 香西克之, 早崎治明, 山崎要一

    小児歯科学雑誌   55 ( 2 )   261 - 261   2017.4

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  • 顎関節症患者の機能評価のガイドライン(2016改訂版)

    皆木 省吾, 山崎 要一, 矢谷 博文, 志賀 博, 山口 泰彦, 服部 佳功, 吉田 教明, 石垣 尚一, 加藤 均, 三浦 宏之, 荒川 一郎, 岡本 和彦, 小野 高裕, 横山 正起, 岡田 和樹, 小川 徹, 菅沼 岳史, 藤澤 政紀, 沖 和広, 坂口 究, 重本 修伺, 瑞森 崇弘, 小見山 道, 田中 恭恵, 堀 一浩, 渡邉 明, 宮脇 正一, 山田 一尋, 斉藤 一誠, 長谷川 信乃, 早崎 治明, 井上 富雄, 井上 誠, 大川 周治, 川良 美佐雄, 祇園白 信仁, 小林 博, 古谷野 潔, 佐々木 啓一, 田中 昌博, 田村 康夫, 野村 修一, 藤村 哲也, 増田 裕次, 鱒見 進一, 倉持 淳子, 昆 はるか, 櫻井 直樹, 山本 早織, 日本顎口腔機能学会, 日本顎口腔機能学会ガイドライン統括委員会

    日本顎口腔機能学会雑誌   23 ( 2 )   E37 - E109   2017.3

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  • 有床義歯装着者の機能評価のガイドライン(2016改訂版)

    皆木 省吾, 山崎 要一, 矢谷 博文, 志賀 博, 山口 泰彦, 服部 佳功, 吉田 教明, 石垣 尚一, 加藤 均, 三浦 宏之, 荒川 一郎, 岡本 和彦, 小野 高裕, 横山 正起, 岡田 和樹, 小川 徹, 菅沼 岳史, 藤澤 政紀, 沖 和広, 坂口 究, 重本 修伺, 瑞森 崇弘, 小見山 道, 田中 恭恵, 堀 一浩, 渡邉 明, 宮脇 正一, 山田 一尋, 斉藤 一誠, 長谷川 信乃, 早崎 治明, 井上 富雄, 井上 誠, 大川 周治, 川良 美佐雄, 祇園白 信仁, 小林 博, 古谷野 潔, 佐々木 啓一, 田中 昌博, 田村 康夫, 野村 修一, 藤村 哲也, 増田 裕次, 鱒見 進一, 倉持 淳子, 昆 はるか, 櫻井 直樹, 山本 早織, 日本顎口腔機能学会, 日本顎口腔機能学会ガイドライン統括委員会

    日本顎口腔機能学会雑誌   23 ( 2 )   E3 - E35   2017.3

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  • Evidence Based Dentistry in Pediatric Dentistry(8)外傷による乳歯完全脱臼への対応

    鹿児島暁子, 大島邦子, 早崎治明, 中村由紀, 澤味規, 岩瀬陽子, 齊藤一誠, 近藤淳子

    小児歯科学雑誌   55 ( 1 )   77‐78 - 78   2017.2

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  • 小児における口呼吸と食べ方の関連性について

    辻井利弥, 稲田絵美, 村上大輔, 白澤良執, 窪田直子, 武元嘉彦, 森園健, 山崎要一, 齊藤一誠, 中島努, 野上有紀子, 早崎治明

    小児歯科学雑誌   55 ( 1 )   152‐153 - 153   2017.2

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  • 体幹傾斜と頸部,頭部屈曲が咀嚼運動に与える影響

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    新潟歯学会雑誌   46 ( 2 )   106 - 106   2016.12

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    新潟歯学会雑誌   46 ( 2 )   116‐117 - 117   2016.12

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    新潟歯学会雑誌   46 ( 2 )   117‐118 - 118   2016.12

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    新潟歯学会雑誌   46 ( 2 )   105‐106 - 106   2016.12

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  • Morphological characteristics of facial soft tissue of mouth-breathing children.

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    PDAA   2016.5

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    PDAA   2016.5

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    小児歯科学雑誌   54 ( 1 )   57 - 57   2016.2

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  • 食事介助の方向が捕食時の姿勢に及ぼす影響

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  • A群レンサ球菌のPI3K/Akt活性化因子を介した咽頭上皮細胞株への付着・侵入メカニズムの解析

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  • マクロファージ機能障害を惹起するレンサ球菌由来分子の同定と解析

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    新潟歯学会雑誌   45 ( 2 )   96‐97 - 97   2015.12

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  • Lymphoid enhancer factor‐1promoterを用いた乳歯歯髄幹細胞様細胞の単離

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  • 「口唇閉鎖力測定器」を用いた小児の口腔管理

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    デンタルエコー   182   18‐29   2015.11

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    小児歯科学雑誌   53 ( 1 )   101 - 102   2015.2

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  • 小児の口腔機能の重要性

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    Dent Diam   40 ( 1 )   38 - 42   2015.1

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  • Streptococcus pyogenes CAMP factorのRAW264.7細胞に対する空胞形成メカニズムの検討

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    Journal of Oral Biosciences Supplement (Web)   2015   ROMBUNNO.P1‐84 (WEB ONLY)   2015

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  • 捕食量による咀嚼運動の相違

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    新潟歯学会雑誌   44 ( 1 )   1 - 11   2014.6

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    小児歯科学雑誌   52 ( 2 )   255 - 255   2014.4

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  • Evidence Based Dentistry in Pediatric Dentistry(5)歯磨きについて

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    小児歯科学雑誌   52 ( 1 )   114 - 115   2014.2

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  • 一口量の変化と食塊粒子分布の関連性について

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  • Comprehensive Long-term Management of Patient with Severe Dental Caries from Early Childhood

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    小児歯科学雑誌   51 ( 4 )   447 - 455   2013.11

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    障害者歯科   34 ( 4 )   653 - 660   2013.10

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  • 歯科衛生士によるブラッシング運動の三次元的解析

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    障害者歯科   34 ( 3 )   343 - 343   2013.9

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  • Three-dimensional analyses of pharyngeal airway form and volume of soft tissue inside the jaw in children with different anteroposterior skeletal patterns

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    小児歯科学雑誌   51 ( 2 )   221 - 221   2013.4

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  • Choice of feeders is important for the preparation of iPS cells from primarily cultured human deciduous tooth dental pulp cells

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    小児歯科学雑誌   51 ( 2 )   166 - 166   2013.4

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  • A case of bilateral supernumerary teeth each residual ridge corner corresponding with bilateral cleft lip

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    小児歯科学雑誌   51 ( 2 )   182 - 182   2013.4

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  • マスキング効果を利用した介助磨きの評価法の検討

    大島邦子, 齊藤一誠, 岩瀬陽子, 中島努, 黒澤美絵, 村上智哉, 村上望, 君雅水, 早崎治明

    成育歯科医療研究会会誌   12 ( 1 )   144 - 144   2013.4

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  • 上気道流体シミュレーションの臨床応用 1.CBCTの上気道への応用

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    成育歯科医療研究会会誌   12 ( 1 )   5 - 6   2013.4

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  • Evidence Based Dentistry in Pediatric Dentistry(4)全身麻酔

    岩瀬陽子, 齊藤一誠, 大島邦子, 黒澤美絵, 村上智哉, 村上望, 君雅水, 早崎治明

    小児歯科学雑誌   51 ( 1 )   49 - 50   2013.3

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  • 【子どものお口のスペシャリストになろう】(第1章)小児患者のマネジメント 小児の成長と受容

    大島 邦子, 早崎 治明

    DHstyle   6 ( 10 )   014 - 017   2012.9

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  • 子どものお口のスペシャリストになろう

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    DH style   6 ( 10 )   5 - 133   2012.9

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  • 上気道流体シミュレーションを用いた小児閉塞性睡眠時無呼吸症候群への取り組み

    岩崎智憲, 嘉ノ海龍三, 齊藤一誠, 覚野恵梨子, 早崎治明, 山崎要一

    日本歯科医師会雑誌   65 ( 5 )   604 - 604   2012.8

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  • 上気道流体シミュレーションを用いた上顎骨急速拡大による歯科治療前後の吸気時咽頭気道圧の評価

    岩崎 智憲, 齊藤 一誠, 原田 みずえ, 宮下 圭一, 松根 彰志, 武元 嘉彦, 深水 篤, 佐藤 秀夫, 稲田 絵美, 長谷川 大子, 覚野 恵梨子, 嘉ノ海 龍三, 早崎 治明, 黒野 祐一, 山崎 要一

    日本睡眠学会定期学術集会プログラム・抄録集   37回   255 - 255   2012.6

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  • Evidence Based Dentistry in Pediatric Dentistry

    早崎治明, 大島邦子, 長谷川大子, 齊藤一誠, 山崎要一

    小児歯科学雑誌   50 ( 1 )   67 - 68   2012.3

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  • 若年者顎関節症患者の関節窩および下顎頭形態と関節円板前方転位との関係

    長谷川大子, 齋藤一誠, 重田浩樹, 田中みゆき, 山崎要一, 大島邦子, 早崎治明

    小児歯科学雑誌   50 ( 1 )   142 - 143   2012.3

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  • 上気道流体シミュレーションの顎骨延長術への臨床応用

    近藤俊, 今村基尊, 奥本隆行, 吉村陽子, 岩崎智憲, 早崎治明, 山崎要一, 嘉ノ海龍三

    日本形成外科学会会誌   32 ( 2 )   129 - 129   2012.2

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  • 子どもの顎関節症の背景と治療 1 子どもの顎関節―その発育と顎関節症

    長谷川大子, 齊藤一誠, 山崎要一, 大島邦子, 早崎治明

    歯界展望   119 ( 1 )   86 - 93   2012.1

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  • CBCTを用いた上顎骨側方急速拡大による舌位改善と咽頭気道拡大の評価

    岩崎智憲, 嘉ノ海龍三, 武元嘉彦, 齊藤一誠, 覚野恵梨子, 早崎治明, 山崎要一

    日本矯正歯科学会大会プログラム・抄録集   71st   118 - 118   2012

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  • 小児歯科のパラダイムシフトと下顎機能の発達

    早崎治明

    新潟歯学会雑誌   41 ( 2 )   117 - 117   2011.12

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  • ブラッシング時の歯ブラシの動的解析

    石井里加子, 大島邦子, 佐野富子, 飯澤二葉子, 沼奈津子, 早崎治明

    新潟歯学会雑誌   41 ( 2 )   135 - 136   2011.12

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  • 小児の咀嚼運動における速度解析

    早崎 治明, 山田 千晶, 大島 邦子, 稲田 絵美, 齊藤 一誠, 山崎 要一

    小児歯科学雑誌   49 ( 4 )   396 - 396   2011.10

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  • 食物の大きさが男女の食事動作に与える影響

    稲田 絵美, 齊藤 一誠, 大島 邦子, 大河原 綾子, 武元 嘉彦, 早崎 治明, 山崎 要一

    小児歯科学雑誌   49 ( 4 )   392 - 392   2011.10

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  • 当大学病院小児歯科における全身麻酔下歯科治療の経時的臨床統計

    稲田 絵美, 齊藤 一誠, 早崎 治明, 徳冨 順子, 佐藤 秀夫, 武元 嘉彦, 乃村 俊樹, 糀谷 淳, 齊藤 陽子, 椙山 加綱, 山崎 要一

    障害者歯科   32 ( 3 )   488 - 488   2011.9

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  • 小児科医のための子どもの歯科 萌出が困難な歯の治療

    早崎治明, 大島邦子

    小児内科   43 ( 8 )   1345 - 1349   2011.8

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  • 閉塞性睡眠時無呼吸症候群への上気道流体シミュレーションの臨床応用

    岩崎智憲, 齊藤一誠, 早崎治明, 山崎要一

    日本歯科医学会誌   30   81 - 81   2011.3

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  • Evaluation of the 2010 Revision in the Payment for Dental Service by Certified Pediatric Dentists : Implementation and problems of "the periodontal tissue examination of the mixed-dentition"

    SHINAGAWA Mitsuharu, TANAKA Mitsuro, INUZUKA Katsuaki, OOHARA Yutaka, KUNIMOTO Youji, SUZUKI Hiroyuki, HAYASAKI Haruaki, FUKUMOTO Satoshi, FUKUMOTO Satoshi

    The Japanese Journal of Pediatric Dentistry   49 ( 1 )   20 - 28   2011.3

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    As the birthrate continues to fall and extreme aging of the population progresses, the governmentand social systems tend to focus on aged individuals. However, health conditions during childhoodgreatly affect the presence or absence of dental problems in adulthood and the older years. Oralhealth and treatment in childhood are therefore extremely important. In this study, questionnaire surveyswere conducted regarding 1) the results of the 2010 revisions in payment for dental service, and2) the periodontal tissue examination of the mixed-dentition. Questionnaires were given to 130 executivemembers of the Japanese Society of Pediatric Dentistry, and analysis was performed on 58 memberswho responded (44.6%). The following results were obtained :1. Results of the revisions in the payment for dental service were considered &quot;very good&quot; by 3.5% ofrespondents, &quot;slightly good&quot; by 39.6%, &quot;quite bad&quot; by 5.2%, &quot;slightly bad&quot; by 17.2%, and &quot;no different&quot;by 34.5%, respectively.2. Comparing the total payment between this year and last year, there was a 1.7% increase in April, a0.6% decrease in May, and a 0.7% decrease in June.3. Causes for the increases in the total payment were given as &quot;an increase of the payment in firstand subsequent visits&quot; by 92.9% of participants, &quot;re-implementation of the additional payment forthose under 6 years old&quot; by 88.9%, and &quot;expansion of infant medical and dental expense aid in municipalities&quot;by 48.0%.4. Causes for decreases of the payment were given as &quot;a decrease in the number of visits by children&quot;by 55.6% of participants, and &quot;a decrease in dental caries&quot; by 52%. Furthermore, 39.1% recognizedthe introduction of &quot;the periodontal tissue examination of the mixed dentition&quot; as causing a decreasein the payment while 60.9% did not.5. Regarding the ratios of executing the various periodontal tissue examinations, the ratio of executingthe periodontal tissue examination of the mixed-dentition was 30.7% in April, 35.7% in May, and35.2% in June. The ratio of executing the basic periodontal examinations was 31.4% in April, 29.1%in May, and 29.8% in June. The ratio of not making an estimate was 37.9% in April, 35.2% in May,and 35.0% in June, which was more than one third.6. Regarding the amount of time required for examinations, &quot;the periodontal tissue examination of themixed dentition&quot; took roughly 7.3 minutes, &quot;the basic periodontal examinations&quot; took roughly 7.2minutes, and &quot;the complete periodontal examinations&quot; took roughly 13.3 minutes.7. Widespread implementation of the periodontal tissue examination of the deciduous- and mixeddentitionis necessary for prevention of periodontal diseases in adulthood. Examination methods touse during the deciduous- and mixed-dentition period and examination forms were devised.

    DOI: 10.11411/jspd.49.1_20

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  • Evaluation of the 2010 Revision in the Payment for Dental Service by Certified Pediatric Dentists.-Implementation and problems of &quot;the periodontal tissue examination of the mixed-dentition&quot;-

    品川光春, 田中光郎, 犬塚勝昭, 大原裕, 國本洋志, 鈴木広幸, 早崎治明, 福本敏

    小児歯科学雑誌   49 ( 1 )   20 - 28   2011.3

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  • Evidence Based Dentistry in Pediatric Dentistry(1)診療ガイドラインについて

    早崎治明, 松山順子, 佐野富子, 林(坂井)幸子, 金城奈津子, 大島邦子

    小児歯科学雑誌   49 ( 1 )   66 - 66   2011.3

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  • Evidence Based Dentistry in Pediatric Dentistry(2)乳歯用既成冠

    大島邦子, 三富智恵, 河野承子, 飯沢二葉子, 川崎勝盛, 早崎治明

    小児歯科学雑誌   49 ( 1 )   66 - 67   2011.3

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  • 顎顔面表面形状の男女成長量に関する横断的研究

    新海みゆき, 稲田絵美, 齊藤一誠, 深水篤, 窪田直子, 武元嘉彦, 岩崎智憲, 長谷川大子, 徳冨順子, 佐藤秀夫, 山崎要一, 早崎治明

    小児歯科学雑誌   49 ( 1 )   134 - 134   2011.3

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  • 【乳歯冠を再考する】 乳歯冠の海外事情 審美性に配慮した乳歯冠を中心として

    早崎 治明, 大島 邦子, 齊藤 一誠, 稲田 絵美, 山崎 要一

    小児歯科臨床   16 ( 2 )   41 - 44   2011.2

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  • 青年期自閉症者に対する歯磨き支援 : 視覚支援ツールの応用

    當摩 紗衣, 大島 邦子, 早崎 治明, 富沢 美惠子

    小児歯科学雑誌   48 ( 5 )   2010.11

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  • 歯限局型低フォスファターゼ症で報告された変異型組織非特異型アルカリフォスファターゼの解析

    金城 奈津子, 大島 邦子, 織田 公光, 早崎 治明

    小児歯科学雑誌   48 ( 5 )   576 - 576   2010.11

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  • 青年期自閉症者に対する歯磨き支援―視覚支援ツールの応用―

    當摩紗衣, 大島邦子, 早崎治明, 富沢美惠子

    小児歯科学雑誌   48 ( 5 )   633 - 633   2010.11

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  • 知っておきたい「小児歯科」4.歯並び・噛み合わせの異常と口腔機能

    山崎要一, 岩崎智憲, 齊藤一誠, 早崎治明

    小児科臨床   63 ( 11 )   2253 - 2262   2010.11

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  • 実験的咬合性外傷における歯周組織破壊・改変に伴うアクアポリン1発現の変化

    河野承子, 河野芳朗, 三富智恵, 田口洋, 早崎治明, 前田健康

    Journal of Oral Biosciences   52 ( Supplement )   148 - 148   2010.9

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  • アルキル化抗腫瘍薬によるラット歯根形成障害に関する組織形態学的解析

    三富智恵, 河野芳朗, 河野承子, 田口洋, 早崎治明, 前田健康

    J Oral Biosci   52 ( Supplement )   151 - 151   2010.9

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  • 小児の顎口腔機能評価のガイドライン 顎運動検査

    志賀 博, 井上 富雄, 佐々木 啓一, 津賀 一弘, 矢谷 博文, 山口 泰彦, 吉田 教明, 山崎 要一, 早崎 治明, 日本顎口腔機能学会, 顎口腔機能評価検討委員会, 小児の顎口腔機能評価のガイドライン作成委員会

    日本顎口腔機能学会雑誌   17 ( ガイドライン )   E172 - E193   2010.9

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  • 口蓋床を用いた口唇顎口蓋裂児の早期治療―作業模型の製作方法の違いによる上顎形態に及ぼす治療効果―

    落合聡, 山田千晶, 森下格, 雑賀厚臣, 長谷川大子, 山本晋也, 齊藤一誠, 早崎治明, 山崎要一

    日本口蓋裂学会雑誌   35 ( 2 )   118 - 118   2010.4

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  • 低位乳臼歯による歯列咬合異常への対応

    徳冨 順子, 岩崎 智憲, 早崎 治明, 山崎 要一

    小児歯科学雑誌   48 ( 2 )   2010.4

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  • 上気道流体シミュレーションを用いた小児閉塞性睡眠時無呼吸症候群の通気障害部位の特定方法について

    岩崎 智憲, 早崎 治明, 嘉ノ海 龍三, 武元 嘉彦, 齋藤 一誠, 松根 彰志, 黒野 祐一, 山崎 要一

    小児歯科学雑誌   48 ( 2 )   244 - 244   2010.4

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  • 低位乳臼歯による歯列咬合異常への対応

    徳冨順子, 岩崎智憲, 早崎治明, 山崎要一

    小児歯科学雑誌   48 ( 2 )   289 - 289   2010.4

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  • 若年者顎関節症患者における下顎頭形態と関節円板前方転位の関係

    長谷川大子, 重田浩樹, 松本祐子, 早崎治明, 山崎要一, 吉原俊博

    小児歯科学雑誌   48 ( 1 )   186 - 187   2010.3

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  • Frequency of Congenitally Missing Permanent Teeth in Japanese Children

    YAMASAKI Youich, IWASAKI Tomonori, HAYASAKI Haruaki, SAITOH Issei, TOKUTOMI Junko, YAWAKA Yasutaka, INOUE Mitsuko, ASADA Yoshinobu, TAMURA Yasuo, KANOMI Ryuzo, MAKI Kensi, YOSHIHARA Toshihiro, FUNATSU Takahiro, TESHIMA Yoko, UESATO Chika, YAMASHITA Kazue, IDE Masamichi, KURIYAMA Tihiro, KONDO Tsuguko, KATOH Mikio, WATANABE Kyoko, FUJITA Yuuko, HASEGAWA Hiroko, INADA Emi, ASADA Yoshinobu

    The Japanese Journal of Pediatric Dentistry   48 ( 1 )   29 - 39   2010.3

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    Congenitally missing permanent teeth (CMPT) is one of the most frequent anomalies in dentistry. CMPT affects not only the occlusal relationships within the maxilla and mandible, but also the total occlusion. In addition CMPT can lead to future skeletal and facial problems. The purpose of this study was to estimate the nation-wide frequency of (CMPT) in Japanese children. Prior to beginning this epidemiological study, the authors obtained permission for the investigation from the ethics committee of Kagoshima University Graduate School of Medical and Dental Sciences (June 25&lt;sup&gt;th&lt;/sup&gt;, 2007).Seven pediatric clinics at dental colleges or universities and several private pediatric clinics participated in this study. The sample consisted of 15,544 pediatric dental patients (7,502 males and 7,502 females). Data were collected from longitudinal dental X-rays, orthopantomograms, and some dental models to determine CMPT (excluding 3&lt;sup&gt;rd &lt;/sup&gt;molars) within 6 months. All patients were judged to be over 7 years of age if they had all their permanent teeth in the dental films. In cases where it was difficult to judge the kind of tooth or its location, the committee members from all 7 colleges/universities reached a consensus on the number of missing teeth and their locations on a case by case basis.A total of 1,568 subjects (10.09%) were diagnosed with CMPT. Of these, 685 were males (9.13%),and 883 were females (10.98%). Differences between the maxilla and the mandible were seen in 4.37% of males and 7.58% of females. Differences between the right and left sides were seen in 0.11% of males and 0.14% of females. The most common missing tooth was the lower second premolar ; missing in 2.96% of adolescents, 2.64% of males (1.32% both sides) and 3.31% of females (1.72% on the right side and 1.59% on the left side). In descending order the next most common missing teeth were the mandibular lateral incisors, the maxillary second premolars, and the upper lateral incisors.

    DOI: 10.11411/jspd.48.1_29

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  • 動的咬合誘導終了時に上顎洞内に歯牙腫の発現を認めた一症例

    佐藤秀夫, 岩崎智憲, 早崎治明, 山崎要一

    小児歯科学雑誌   48 ( 1 )   188 - 188   2010.3

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  • 幼稚園児・保育園児の口呼吸に関する研究

    奥猛志, 井形紀子, 禧久めぐみ, 大内山晶子, 弘野美紀, 四元みか, 佐藤秀夫, 早崎治明, 山崎要一

    小児歯科学雑誌   48 ( 1 )   186 - 186   2010.3

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  • 上顎急速拡大前後の鼻腔通気状態に関する流体シミュレーション評価

    岩崎智憲, 齊藤一誠, 武元嘉彦, 嘉ノ海龍三, 早崎治明, 山崎要一

    日本矯正歯科学会大会プログラム・抄録集   69th   138 - 138   2010

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  • Three-dimensional Analysis of Facial Surface Morphology in Japanese Infant : 2. Dimensional measurements

    NISHIJIMA Naomi, FUKAMI Atsushi, IWASAKI Tomonori, TAKEMOTO Yoshihiko, KUBOTA Naoko, INADA Emi, IGATA Noriko, OKU Takeshi, SAITOH Issei, HAYASAKI Haruaki, YAMASAKI Youichi

    The Japanese Journal of Pediatric Dentistry   47 ( 5 )   726 - 731   2009.12

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    The process of facial growth is of interest in dentistry, physical anthropology, and even industry. Several Japanese national institutes, e.g., the Advanced Industrial Science and Technology and the Research Institute of Human Engineering for Quality Life have measured and reported aspects of human body size and shape, including the facial morphology of children and adults. However, the facial morphology of infants was not included in these reports.In this study, three-dimensional facial morphological measurements of infants were performed using a three-dimensional laser surface-scanner system (VIVID 910, KONICA MINOLTA SENCING, Inc. Osaka, Japan). One hundred and twenty normal developing children (20 boys and 20 girls each at 4, 5 and 6 years of age) had their faces scanned by VIVID. Four widths (inter-Exocanthion width,inter-Endocanthion width, inter-Alar crest width and inter-Cheilion width) and 6 heights (Nasal height, upper facial height, mouth height, total facial height, lower facial height and Vermilion height) were measured.Most measurements increased with age in both boys and girls. Although significant sex-related differences were detected among the three age groups, there were no consistent tendencies. The infants&#039;growth rates for the measurements were not the same as those of adults from the literature. [I do not understand the next sentence. Perhaps you mean : &quot;For example, widths in the upper part of the face at four years of age are already 80% that of adults. Most measurements differed significantly between 5 and 6 years of age, but only 2 measurements differed significantly between 4 and 5 years of age. These results suggest that facial growth is not constant between 4 and 6 years of age, with rates affected by both age and sex. Further investigation may be required to elucidate characteristics of facial growth during childhood.

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  • Three-dimensional Analysis of Facial Surface Morphology in Japanese Infant : 1. Establishing a standard coordinate system

    NISHIJIMA Norihiro, FUKAMI Atsushi, INADA Emi, HASEGAWA Hiroko, IWASE Yoko, IGATA Noriko, OKU Takeshi, SAITOH Issei, HAYASAKI Haruaki, YAMASAKI Youichi

    The Japanese Journal of Pediatric Dentistry   47 ( 5 )   719 - 725   2009.12

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    Recording and analysis of normal patterns of growth and development of the human face are among the most important clinical observations. Three-dimensional digitization technologies can now record three-dimensional coordinates of facial surfaces, allowing direct analyses of landmark coordinates that provide the basis for statistical differences in facial shape during growth and development. The aim of this study was to compare methodologies used to establish the three-dimensional coordinate system for quantifying facial morphology.The three-dimensional facial morphology of infants was recorded using a three-dimensional laser surface scanner system (VIVID 910, KONICA MINOLTA SENCING, Inc. Osaka, Japan). One hun dred and twenty normal developing children (20 boys and 20 girls each at 4, 5 and 6 years of age) had their faces scanned by VIVID.Two origins and two reference planes for the scanned data were established and compared to evaluate the effectiveness and importance of the selected coordinate system. The first origin was at Nasion on the soft tissue, and the second was defined as the mid-point of both the right and left Endocanthion points. The first reference plane was a Nasal triangle based on three reference markers : soft tissue Nasion in the midline and Alar crests on each side. The second plane was based on 8 points,Exocanthion, Endocanthion, Alar crest and Cheilion on both right and left sides. The vertical axis was defined using 6 points : G, S, Prn, Ls, Li and Pog. The lateral axis was perpendicular to the vertical axis on the established plane, and the anterior-posterior axis had the same direction as the unit vector of the plane.The Endocanthion mid-point was the better origin, resulting in slightly smaller standard deviations and coefficients of variance of all measurements, especially on the vertical axis and three-dimensional distances. When the two reference planes were compared using this origin they differed for measurements in the sagittal plane by an average of 9.7 degrees. This angle decreased with growth, and a statistically significant difference was found between 4- and 6-year-old girls. No significant differences were detected on the horizontal plane.These results suggest that the selection of the coordinate system can influence observed measurements of growth, development and even treatment effects of the face. Therefore, the coordinate system should be chosen based on the purpose of the study and the characteristics of each landmark.

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  • 口唇裂・口蓋裂児のHotz型人工口蓋床による早期治療効果の検討

    山田千晶, 落合聡, 森下格, 長谷川大子, 山本晋也, 齊藤一誠, 早崎治明, 山崎要一

    障害者歯科   30 ( 3 )   413 - 413   2009.9

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  • 口唇裂・口蓋裂児の Hotz 型人工口蓋床による早期治療効果の検討

    山田 千晶, 落合 聡, 森下 格, 長谷川 大子, 山本 晋也, 齊藤 一誠, 早崎 治明, 山崎 要一

    障害者歯科   30 ( 3 )   2009.9

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  • Oropharyngeal airway in children with Class III malocclusion evaluated by cone-beam computed tomography

    Tomonori Iwasaki, Haruaki Hayasaki, Yoshihiko Takemoto, Ryuzo Kanomi, Youichi Yamasaki

    AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS   136 ( 3 )   2009.9

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    Introduction: Upper airway size is increasingly recognized as an important factor in malocclusion. However, children with Class III malocclusion are somewhat neglected compared with those with a Class II skeletal pattern. Therefore, the purpose of this study was to establish the characteristic shape of the oropharyngeal airway (OA) in children with Class III malocclusion.
    Methods: The sample comprised 45 children (average age, 8.6 +/- 1.0 years) divided into 2 groups: 25 with Class I and 20 with Class III malocclusions. OA size of each group was evaluated by cone-beam computed tomography. Cluster analysis, based on OA shape, redivided the subjects into wide, square, and long types. The distributions of Class I and Class III subjects were compared among the types.
    Results: The Class III group showed statistically larger OA area and width compared with the Class I group. Area was positively correlated with Class III severity. The square type included 84% of the Class I malocclusions but only 30% of the Class III malocclusions, indicating that the OA in Class III malocclusion tends to be flat.
    Conclusions: The Class III malocclusion is associated with a large and flat OA compared with the Class I malocclusion.

    DOI: 10.1016/j.ajodo.2009.04.010

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  • 気道と顎顔面形態との関連

    岩崎智憲, 早崎治明, 山崎要一, 嘉ノ海龍三

    成育歯科医療研究会会誌   11 ( 1 )   63 - 63   2009.8

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  • 上気道流体シミュレーションを用いた咬合治療への臨床応用

    岩崎智憲, 嘉ノ海龍三, 早崎治明, 武元嘉彦, 山崎要一

    成育歯科医療研究会会誌   11 ( 1 )   DAI13KAI,24 - 24   2009.8

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  • 呼吸と顎顔面形態との関連

    岩崎智憲, 嘉ノ海龍三, 早崎治明, 山崎要一

    成育歯科医療研究会会誌   11 ( 1 )   6 - 7   2009.8

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  • 咬合の育成と治療 小児の顎関節 その成長発育にともなう形態と機能

    早崎 治明

    日本顎関節学会雑誌   21 ( Suppl. )   75 - 75   2009.7

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  • 頭部エックス線規格写真と歯列模型を用いた顎顔面形態と歯軸傾斜角度の三次元解析

    稲田 絵美, 齊藤 一誠, 早崎 治明, 窪田 直子, 武元 嘉彦, 山崎 要一

    小児歯科学雑誌   47 ( 2 )   221 - 221   2009.4

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  • 小児における咀嚼運動の円滑性に関する研究 : Jerk cost による顎運動機能評価

    山田 千晶, 齊藤 一誠, 社 浩太郎, 早崎 治明, 高田 健治, 山崎 要一

    小児歯科学雑誌   47 ( 2 )   2009.4

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  • 小児における咀嚼運動の円滑性に関する研究―Jerk costによる顎運動機能評価―

    山田千晶, 齊藤一誠, 社浩太郎, 早崎治明, 高田健治, 山崎要一

    小児歯科学雑誌   47 ( 2 )   360 - 360   2009.4

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  • 小児の口唇閉鎖力の発達に関する研究

    深水篤, 齊藤一誠, 稲田絵美, 武元嘉彦, 山田千晶, 早崎治明, 山崎要一, 奥猛志

    小児歯科学雑誌   47 ( 1 )   194 - 194   2009.3

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  • 化学療法・放射線療法が歯の形成に与える臨床的影響

    長谷川大子, 山本晋也, 稲田絵美, 早崎治明, 山崎要一, 稲田浩子, 森下格, 落合聡, 齊藤一誠

    小児歯科学雑誌   47 ( 1 )   192 - 192   2009.3

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  • Dentition and Occlusion Management in a Patient with an Impacted Supernumerary Tooth on the Nasal side of the Inversely Impacted Right Maxillary Central Incisor

    SHIGETA Koki, IWASAKI Tomonori, SAITOH Issei, HAYASAKI Haruaki, YAMASAKI Youichi

    The Japanese Journal of Pediatric Dentistry   47 ( 1 )   111 - 118   2009.3

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    A girl, aged 8-years and 10-months old, was brought to our hospital for treatment of the maxillary impacted supernumerary teeth. A radiographic examination revealed that the right maxillary central incisor was impacted, and two supernumerary teeth were located palatal to the left maxillary central incisor and nasally to the impacted right maxillary central incisor.&lt;br/&gt;&lt;br/&gt;The right maxillary central incisor was planned to be preserved in this patient. The left supernumerary tooth was first extracted, and through the extraction space, the right supernumerary tooth was exposed and removed. Orthodontic therapy was then performed using a maxilla fixing device and sectional arch to gradually bring the right maxillary central incisor to its proper position. Since the patient&#039;s family was planning to move in one year, multibrackets were used during this period to achieve favorable tooth position and occlusion.&lt;br/&gt;&lt;br/&gt;In this patient, it was difficult to bring the inverted and impacted central incisor to the proper position orthodontically. Thorough examination and good clinical skills were required to perform the or thodontic therapy, while preserving the dental pulp without damaging the root apex of the central incisor. The impacted supernumerary teeth had to be carefully removed to prevent damage to the central incisor.&lt;br/&gt;&lt;br/&gt;The patient and her parents were satisfied with the treatment outcome. In addition to promoting oral development, we were able to gain knowledge and improve our clinical skills.

    DOI: 10.11411/jspd.47.1_111

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  • Effect of maxillary protrusion on upper airway obstruction in children by fluid-mechanical simulation

    IWASAKI Tomonori, HAYASAKI Haruaki, KANOMI Ryuzo, SAITOH Issei, YAMASAKI Youichi

    小児耳鼻咽喉科   30 ( 1 )   5 - 9   2009.3

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  • 上気道流体シミュレーションからみた通気状態が顎顔面形態に及ぼす歯科的影響

    岩崎智憲, 早崎治明, 嘉ノ海龍三, 齊藤一誠, 山崎要一

    小児耳鼻咽喉科   30 ( 1 )   5 - 9   2009.3

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  • 下顎滑走運動

    早崎 治明

    鹿児島大学歯学部紀要   29   57 - 65   2009.3

  • Measurement of Tongue Pressure during Swallowing Using Sensor Sheet System

    Terajima Masahiko, Endo Mizuki, Aoki Yoshimitsu, Yuuda Kyouko, Hayasaki Haruaki, Goto Tazuko K, Tokumori Kenji, Nakashima Akihiko

    The Journal of Japanese Society of Stomatognathic Function   14 ( 2 )   100 - 101   2008.2

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    DOI: 10.7144/sgf.14.100

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  • 流体シミュレーションからみた上気道通気障害が上顎前突に及ぼす影響―BrachyとDolicho typeの比較―

    岩崎智憲, 嘉ノ海龍三, 早崎治明, 山崎要一

    日本矯正歯科学会大会プログラム・抄録集   67th   127 - 127   2008

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  • Four-dimensional analyzing system of the stomatognathic function

    TERAJIMA Masahiko, ENDO Mizuki, AOKI Yoshimitsu, YUUDA Kyouko, HAYASAKI Haruaki, GOTO Tazuko K, TOKUMORI Kenji, NAKASIMA Akihiko

    日本顎口腔機能学会学術大会   39 ( 39 )   10 - 11   2007.10

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  • 下顎骨の成長とGHR P561T変異の関係についての分子遺伝学的研究

    佐々木 康成, 佐藤 恭子, 早崎 治明, 福本 敏, 藤原 卓, 野中 和明

    小児歯科学雑誌   44 ( 2 )   162 - 162   2006.4

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    DOI: 10.11411/jspd1963.44.2_162

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  • 就学前児童にエナメル上皮腫発症を疑った1例

    石橋 真由子, 早崎 治明, 福本 敏, 中村 誠司, 野中 和明

    小児歯科学雑誌   44 ( 2 )   191 - 191   2006.4

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    DOI: 10.11411/jspd1963.44.2_191

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  • Four-dimensional analyzing system of the stomatognathic function : Application to the patients with jaw deformities

    Terajima Masahiko, Endo Mizuki, Aoki Yoshimitsu, Yuuda Kyouko, Hayasaki Haruaki, Goto Tazuko, Tokumori Kenji, Nakashima Akihiko

    The Journal of Japanese Society of Stomatognathic Function   12 ( 2 )   100 - 109   2006.2

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    We introduce a new method of four-dimensional display of mandibular movement using the 3D-CT images of the skull and mandible, the dental surface image using a non-contact 3-D laser scanner and the mandibular movement data using a six-degree-of freedom-jaw movement analyzer. This method was employed to perform dynamic and precise simulation of the mandibular function for a patient with jaw deformity. The advantages of this system were as follows: 1. The dento-skeletal 3D image and the mandibular movement data were integrated on the same coordinates on a personal computer. The mandibular movement of multiple required points on the integrated images was displayed by the computer graphics, which make it possible clearly to grasp a relationship between the motion pattern of the mandibular movement, skeletal morphology and occlusion simultaneously. 2. This new method of analyzing the occlusal contacts and the condyle-fossa distance provides the comprehensive insight of the stomatognathic system not only at intercuspal position, but also at any mandibular positions during functional movement. 3. Our system to evaluate the intersection between morphology and function will certainly improve our understanding of the function of the temporpmandibular joint and occlusion. We believe that it is useful for diagnosing the temporomandibular disorders to patients with jaw deformities.

    DOI: 10.7144/sgf.12.100

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  • Four-dimensional analyzing system of the stomatognathic function-Application to the patients with jaw deformities-

    寺嶋雅彦, 遠藤みずき, 青木義満, 祐田京子, 早崎治明, 後藤多津子, 徳森謙二, 中島昭彦

    日本顎口腔機能学会雑誌   12 ( 2 )   100 - 109   2006.2

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  • Correlations between Incisor and Condyles during Protrusion in Anterior Crossbite Children with Primary Dentition

    Tokutomi Junko, Saitoh Issei, Hayasaki Haruaki, Iwase Yoko, Yamasaki Youichi, Nonaka Kazuaki

    The Journal of Japanese Society of Stomatognathic Function   12 ( 1 )   37 - 44   2005.10

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    The purpose of this study was to characterize mandibular movement during protrusion in anterior crossbite children with primary dentition. Mandibular movements were measured using a TRI-MET^[○!R], an optoelectronic analysis system with six degrees-of-freedom, at a sampling frequency of 100Hz. This measurement data was transferred to a graphics workstation for analysis. The subjects with primary dentition were categorized into two groups according to their interocclusal relations, group one had normal occlusion and group two had anterior crossbite. The former group consisted of 20 children (mean age : 5 years and 6 months), and the latter group consisted of 15 children (mean age : 4 years and 9 months). Anterior-posterior range, right-left range, superior-inferior range and three-dimensional linear distance of the incisal point and the condylar points during protrusion were estimated by using multilevel statistical models. Correlation coefficients between incisor and condylar distances were evaluated at both the inter-individual and intra-individual levels. The study&#039;s results were : 1) Protrusion of the anterior crossbite group was characterized by smaller ranges and distances of both the incisors and condyles than children with normal occlusion. This suggests that when the teeth are at maximum intercuspal position the condyle is located more anteriorly in anterior crossbite children than in normal children. 2) High correlation coefficients in both groups of children, suggest that condylar movements during protrusion can be reliably estimated from incisor movements. 3) Intra-individual correlations of normal occlusion children were larger than their inter-individual correlations, but the reverse was true for anterior crossbite children.

    DOI: 10.7144/sgf.12.37

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  • 当大学病院小児歯科における全身麻酔下治療の実態

    早崎 治明, 明〓 征美, 藤瀬 多佳子, 緒方 哲朗, 福本 敏, 野中 和明

    小児歯科学雑誌   43 ( 2 )   347 - 347   2005.4

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    DOI: 10.11411/jspd1963.43.2_347

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  • 顎変形症患者における下顎運動四次元表示システム

    寺嶋 雅彦, 祐田 京子, 青木 義満, 早崎 治明, 徳森 謙二, 後藤 多津子, 樋口 惣, 中島 昭彦

    日本顎関節学会雑誌   17 ( 1 )   92 - 92   2005.4

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  • 顎運動の四次元表示システムの開発

    寺嶋雅彦, 祐田京子, 青木義満, 早崎治明, 後藤多津子, 徳森謙二, 樋口惣, 中島昭彦

    日本顎変形症学会雑誌   14 ( 3 )   252 - 253   2004.12

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  • Head movement cooperated with a series of mandibular movement in children

    Kuroda Kuniyasu, Yamasaki Youichi, Hayasaki Haruaki, Nakata Minoru

    The Journal of Japanese Society of Stomatognathic Function   11 ( 1 )   63 - 65   2004.11

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    DOI: 10.7144/sgf.11.63

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  • Four-dimensional display system of mandibular movement for patients with jaw deformities

    TERAJIMA Masahiko, YUUDA Kyouko, AOKI Yoshimitsu, HAYASAKI Haruaki, TOKUMORI Kenji, GOTO Tazuko, HIGUCHI Sou, NAKASIMA Akihiko

    Orthod Waves-Jpn Ed   63 ( 3 )   193 - 205   2004.10

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    We introduce a new method for fourdimensional (4D) display of mandibular movement using the three-dimensional reconstructed computed tomography (3D-CT) of the skull and mandible, the dental surface image using a non-contact 3-D laser scanner, and the mandibular movement data using a six-degree-of freedom-jaw movement with the analyzer &quot;TRI-MET&quot;. This method was employed to perform dynamic and precise simulation of the mandibular function for a patient with jaw deformity. The advantage of this system were as follows : 1. The maxillofacial 3 D-CT image and the 3-D dental surface image were integrated on the same coordinates by using the ceramic balls as markers. The least squares method was employed to match morphological images in registration process. 2. The mandibular movement data were then converted to the same coordinates on the 3-D integrated image using the ceramic balls. The relationship between the motion pattern of the mandibular movement and the occlusal condition were visualized four dimensionally. 3. We believe that this new method to evaluate mandibular function by using computer graphics will be useful for diagnosing the temporomandibular disorders to the patients with jaw deformities. It provides easy-to-understand informations not to the orthodontists, but also the patients.

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  • Jaw Structure and Function Visualization for Diagnosis Using Head Model-4D Jaw Movement Visualization System-

    青木義満, 寺嶋雅彦, 早崎治明, 中島昭彦

    電子情報通信学会技術研究報告   104 ( 88(PRMU2004 1-11) )   1 - 6   2004.5

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  • Jaw Structure and Function Visualization for Diagnosis/Using Head Model : 4D Jaw Movement Visualization System

    AOKI Yoshimitsu, TERAJIMA Masahiko, HAYASAKI Haruaki, NAKASIMA Akihiko

    IEICE technical report. Welfare Information technology   104 ( 92 )   1 - 6   2004.5

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    Recently, several attempts to investigate the relationship between facial skeleton and temporomandibular joint morphology, occulusal condition and the characteristics of mandibular movement have been made. As for temporomandibular disorder and jaw deformity, 3D understanding of mandibular structure and movement is generally important in diagnosis. However, traditional techniques do not allow total evaluation of jaw structure and movement as 3D information. In this study, we introduce a new method for four-dimensional(4D) display system of mandibular structure (3D) and movement(+1D). Jaw and teeth structure model are exactly constructed using 3D data from 3D-CT and 3D-LS (non-contact 3-D laser scanner), respectively. 6DOF jaw trajectory measured by a motion tracker (TRI-MET) is given to the structural model. Integration of the structure model and jaw movement is performed using reference spheres attached to the jaw and teeth. We also propose an automatic extraction and position detection of spheres in 3D data for integration in high accuracy. This method was employed to perform dynamical simulation of the mandibular function for patients with jaw deformities on a computer. By this system, we can visualize invisible inner movement of jaw using 3D image processing techniques.

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  • Jaw Structure and Function Visualization for Diagnosis/Using Head Model : 4D Jaw Movement Visualization System

    AOKI Yoshimitsu, TERAJIMA Masahiko, HAYASAKI Haruaki, NAKASIMA Akihiko

    IEICE technical report.   104 ( 90 )   1 - 6   2004.5

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    Recently, several attempts to investigate the relationship between facial skeleton and temporomandibular joint morphology, occulusal condition and the characteristics of mandibular movement have been made. As for temporomandibular disorder and jaw deformity, 3D understanding of mandibular structure and movement is generally important in diagnosis. However, traditional techniques do not allow total evaluation of jaw structure and movement as 3D information. In this study, we introduce a new method for four-dimensional(4D) display system of mandibular structure (3D) and movement(+1D). Jaw and teeth structure model are exactly constructed using 3D data from 3D-CT and 3D-LS (non-contact 3-D laser scanner), respectively. 6DOF jaw trajectory measured by a motion tracker (TRI-MET) is given to the structural model. Integration of the structure model and jaw movement is performed using reference spheres attached to the jaw and teeth. We also propose an automatic extraction and position detection of spheres in 3D data for integration in high accuracy. This method was employed to perform dynamical simulation of the mandibular function for patients with jaw deformities on a computer. By this system, we can visualize invisible inner movement of jaw using 3D image processing techniques.

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  • Jaw Structure and Function Visualization for Diagnosis/Using Head Model : 4D Jaw Movement Visualization System

    AOKI Yoshimitsu, TERAJIMA Masahiko, HAYASAKI Haruaki, NAKASIMA Akihiko

    Technical report of IEICE. PRMU   104 ( 88 )   1 - 6   2004.5

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    Recently, several attempts to investigate the relationship between facial skeleton and temporomandibular joint morphology, occulusal condition and the characteristics of mandibular movement have been made. As for temporomandibular disorder and jaw deformity, 3D understanding of mandibular structure and movement is generally important in diagnosis. However, traditional techniques do not allow total evaluation of jaw structure and movement as 3D information. In this study, we introduce a new method for four-dimensional(4D) display system of mandibular structure (3D) and movement(+1D). Jaw and teeth structure model are exactly constructed using 3D data from 3D-CT and 3D-LS (non-contact 3-D laser scanner), respectively. 6DOF jaw trajectory measured by a motion tracker (TRI-MET) is given to the structural model. Integration of the structure model and jaw movement is performed using reference spheres attached to the jaw and teeth. We also propose an automatic extraction and position detection of spheres in 3D data for integration in high accuracy. This method was employed to perform dynamical simulation of the mandibular function for patients with jaw deformities on a computer. By this system, we can visualize invisible inner movement of jaw using 3D image processing techniques.

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  • 低位乳臼歯に伴って臼歯部開こうを生じた症例

    斉藤一誠, 山崎要一, 早崎治明, 渡辺里香, 岩瀬陽子

    小児歯科学雑誌   42 ( 2 )   326   2004.4

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  • 反対こう合を有する混合歯列前期小児の習慣性開閉口運動について

    佐藤恭子, 山崎要一, 早崎治明, 西めぐみ, 徳冨順子

    小児歯科学雑誌   42 ( 2 )   204   2004.4

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  • 三次元模型計測システムを用いた乳歯列解析 : システムおよび上下顎歯列の咬頭頂曲線

    明〓 征美, 落合 聡, 齊藤 一誠, 早崎 治明, 山崎 要一

    小児歯科学雑誌   42 ( 2 )   2004.4

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  • 乳歯列期きょう状こう合の2治験例

    石谷徳人, 山崎要一, 舛元康浩, 早崎治明, 明州征美

    小児歯科学雑誌   42 ( 2 )   318   2004.4

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  • 反対咬合を有する混合歯列前期小児の習慣性開閉口運動について

    佐藤 恭子, 山崎 要一, 早崎 治明, 西 めぐみ, 徳冨 順子

    小児歯科学雑誌   42 ( 2 )   204 - 204   2004.4

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    DOI: 10.11411/jspd1963.42.2_204

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  • 三次元模型計測システムを用いた乳歯列解析‐システムおよび上下顎歯列のこう頭頂曲線‐

    明しゅう征美, 落合聡, 斉藤一誠, 早崎治明, 山崎要一

    小児歯科学雑誌   42 ( 2 )   248 - 248   2004.4

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  • 低位乳臼歯に伴って臼歯部開咬を生じた症例

    齊藤 一誠, 山崎 要一, 早崎 治明, 渡辺 里香, 岩瀬 陽子

    小児歯科学雑誌   42 ( 2 )   326 - 326   2004.4

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    DOI: 10.11411/jspd1963.42.2_326

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  • 乳歯列期鋏状咬合の2治験例

    石谷 徳人, 山崎 要一, 舛元 康浩, 早崎 治明, 明〓 征美

    小児歯科学雑誌   42 ( 2 )   318 - 318   2004.4

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    DOI: 10.11411/jspd1963.42.2_318

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  • An Analysis of Head Movements during Habitual Mandibular Opening and Closing Movements in Children

    KURODA Kuniyasu, YAMASAKI Youichi, HAYASAKI Haruaki, NAKATA Minoru

    小児歯科学雑誌   42 ( 1 )   27 - 35   2004.3

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  • Development of a Measuring System for Sequential Occlusal Aspects

    大谷周平, 早崎治明, 岩瀬陽子, 中田志保, 中田稔

    小児歯科学雑誌   42 ( 1 )   1 - 11   2004.3

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  • Development of a Measuring System for Sequential Occlusal Aspects

    OTANI Shuhei, HAYASAKI Haruaki, IWASE Yoko, NAKATA Shiho, NAKATA Minoru

    小児歯科学雑誌   42 ( 1 )   1 - 11   2004.3

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  • Three-dimensional Areas of Curved Mesh Diagrams of Mandibular Excursion (CMDME) in Children with Primary Dentition

    SAWAMI Tadashi, HAYASAKI Haruaki, NAKATA Shiho, NAKATA Minoru

    小児歯科学雑誌   42 ( 1 )   19 - 26   2004.3

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  • 三次元顎顔面骨格モデルを用いた顎運動の可視化

    祐田京子, 寺嶋雅彦, 青木義満, 早崎治明, 中島昭彦

    日本矯正歯科学会大会プログラム・抄録集   63rd   315 - 315   2004

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  • Relationship between the Lower Incisal Point and Condylar Point during the Habitual Opening Movements of the Mandible in Children with Primary Dentition

    HUANG Raoqing, HAYASAKI Haruaki, NAKATA Shiho, NAKATA Minoru

    Jpn.j.Ped.Dent.   41 ( 3 )   573 - 579   2003.6

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    Mouth opening movements have been used as a method to evaluate mandibular function. This should be based on the fact that both the lower incisal and the condylar movements are deeply interrelated each other, as far as the authors know, no report has been published on children with primary dentition concerning this important matter.&lt;BR&gt;To clarify this point, twenty-fou r children with primary dentition and twenty-six women with healthy permanent dentition were selected as the subjects. Their habitual open-close movements were measured three times, respectively by using an optoelectronic analysis system (TRIMET) with 6 degrees movement at a sampling frequency of 100 Hz. 1) anterior-posterior and 2) vertical ranges,3)three-dimensional straight distance and 4) three-dimensional curvilinear distance were measured and analyzed for both the lower incisor and right and left condyles. Their coefficient variances were also calculated. Coefficient correlations between the lower incisor and condyles among all four variables were calculated to find the relationships between two measuring points. The following results were obtained,&lt;BR&gt;1) Children showed smaller ranges and distances than women for both the lower incisor and condyles.&lt;BR&gt;2) Children had smaller coefficient variances in all variables than children, with the exception of the vertical range for both incisor and condyles.&lt;BR&gt;3) Variables for the lower incisor significantly correlated with those of at condyles both in children and women.&lt;BR&gt;4) The individual coefficient correlation for the items of measurement for the lower incisor and the condyles showed a tendency to be lower for the women than for the children, but the individual coefficient con-elation within each group was smaller for the children than for the women.&lt;BR&gt;According to these results, the habitual opening movement was justified as a subjective movement to estimate the condylar movement from that of the lower incisor for children with primary dentition. Repeated measurements were, however, recommended to apply this movement to children with primary dentition.

    DOI: 10.11411/jspd1963.41.3_573

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  • Relationship between the Lower Incisal Point and Condylar Point during the Habitual Opening Movements of the Mandible in Children with Primary Dentition

    RAOQING H, 早崎治明, 中田志保, 中田稔

    小児歯科学雑誌   41 ( 3 )   573 - 579   2003.6

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  • そしゃく運動における上下の歯のかみ合わせ状態

    早崎治明, 落合聡

    食生活科学・文化及び地球環境科学に関する研究助成研究紀要   16   47 - 53   2003.5

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  • 経時的な咬合面形態計測システムの開発

    大谷 周平, 早崎 治明, 中田 志保, 中田 稔

    小児歯科学雑誌   41 ( 2 )   326 - 326   2003.4

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    DOI: 10.11411/jspd1963.41.2_326

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  • 経時的なこう合面形態計測システムの開発

    大谷周平, 早崎治明, 中田志保, 中田稔

    小児歯科学雑誌   41 ( 2 )   326   2003.4

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  • The Change of the Main Occluding Area at Mastication by Dental Stage

    NAKATA Shiho, WATANABE Rica, HAYASAKI Haruaki, NAKATA Minoru

    小児歯科学雑誌   41 ( 1 )   252 - 258   2003.3

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  • The Change of the Main Occluding Area at Mastication by Dental Stage

    中田志保, 渡辺里香, 早崎治明, 中田稔

    小児歯科学雑誌   41 ( 1 )   252 - 258   2003.3

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  • Masticatory movement during occlusal phase in children with primary dentition and women

    Saitoh Issei, Hayasaki Haruaki, Nakata Shiho, Iwase Yoko, Nakata Minoru

    The Journal of Japanese Society of Stomatognathic Function   9 ( 1 )   23 - 29   2002.11

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    The purpose of this research is to clarify the feature of a chewing movement, especially during occlusal phase, in children with primary dentition. Two groups of subjects were used; children with primary dentition (20 children) and adults with permanent dentition (32 females). Gum chewing motion of the mandible of each subject was measured using a TRIMETR, which can three-dimensionally analyze the simultaneous movements of multiple points on the mandible of a subject. A series of chewing motions were divided into its component cycles, and then chewing patterns were analyzed and compared between two groups. As results, the chopping type was dominant in children, however, it was the grinding type in adults. Also more than 30% of cycles in children were reverse type. The pathway of the movement had relatively larger anterior-posterior and smaller lateral ranges in children compared with adults. Longer occlusal contacts were suggested on the opening stroke than the closing in children. The underlying reason for these findings may be due to physiological growth, maturation, and adaptation of the occlusal function.

    DOI: 10.7144/sgf.9.23

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  • 小児の習慣性開口運動における切歯点と顆頭点との関係

    黄 饒青, 早崎 治明, 中田 志保, 中田 稔

    小児歯科学雑誌   40 ( 2 )   2002.4

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  • 小児の習慣性開口運動における切歯点とか頭点との関係

    黄じょう青, 早崎治明, 中田志保, 中田稔

    小児歯科学雑誌   40 ( 2 )   343 - 343   2002.4

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  • Gum-chewing strokes around occlusal phase.

    H Hayasaki, Saitoh, I, S Nakata, Y Iwase, M Nakata

    JOURNAL OF DENTAL RESEARCH   81   A212 - A212   2002.3

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  • Glucose intolerance and alveolar bone loss in Japanese men.

    T Marugame, H Hayasaki, H Eguchi, S Matsumoto

    JOURNAL OF DENTAL RESEARCH   81   A370 - A370   2002.3

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  • Occlusal angles of working molars during gum-chewing in children.

    Saitoh, I, H Hayasaki, Y Iwase, S Nakata, M Nakata

    JOURNAL OF DENTAL RESEARCH   81   A212 - A212   2002.3

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  • 電動麻酔薬注入器具を用いた局所麻酔

    落合聡, 宮崎葉子, 山下伸子, 永田英子, 倉田可奈子, 鰐石清佳, 佐々木康成, 早崎治明, 中田稔

    障害者歯科   22 ( 4 )   354 - 354   2001.11

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  • 口唇裂口蓋裂児に対するHotz型人工口蓋床を用いた早期治療の効果 合併症を有する症例の体重変化について

    落合聡, 佐々木康成, 柳田憲一, 武田康男, 早崎治明, 中田稔, 渡辺里香, 藤崎みずほ

    日本口蓋裂学会雑誌   26 ( 2 )   177   2001.4

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  • 口唇裂口蓋裂児に対する Hotz 型人工口蓋床を用いた早期治療の効果 : 合併症を有する症例の体重変化について

    落合 聡, 柳田 憲一, 早崎 治明, 渡辺 里香, 藤崎 みずほ, 佐々木 康成, 武田 康男, 中田 稔

    日本口蓋裂学会雑誌   26 ( 2 )   177 - 177   2001.4

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  • 反対こう合を有する混合歯列期小児の習慣性開閉口運動について 切歯点運動路の検討

    佐藤恭子, 山崎要一, 早崎治明, 西めぐみ, 中田稔

    小児歯科学雑誌   39 ( 2 )   445   2001.4

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  • 乳歯列期小児におけるそしゃく運動の特徴 そしゃく終末位付近の経路の解析

    斉藤一誠, 早崎治明, 中田志保, 中田稔

    小児歯科学雑誌   39 ( 2 )   305   2001.4

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  • 小児の開閉口運動時の頭部運動について : 第2報 頭部運動の運動収束点の検索

    黒田 國康, 山崎 要一, 早崎 治明, 中田 稔

    小児歯科学雑誌   39 ( 2 )   306 - 306   2001.4

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    DOI: 10.11411/jspd1963.39.2_306

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  • 乳歯列期小児における咀嚼運動の特微 : 咀嚼終末位付近の経路の解析

    齊藤 一誠, 早崎 治明, 中田 志保, 中田 稔

    小児歯科学雑誌   39 ( 2 )   305 - 305   2001.4

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    DOI: 10.11411/jspd1963.39.2_305

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  • 乳歯列期小児の下顎滑走運動面について

    澤味 規, 早崎 治明, 中田 稔

    小児歯科学雑誌   39 ( 2 )   304 - 304   2001.4

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    DOI: 10.11411/jspd1963.39.2_304

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  • 反対咬合を有する混合歯列期小児の習慣性開閉口運動について : 切歯点運動路の検討

    佐藤 恭子, 山崎 要一, 早崎 治明, 西 めぐみ, 中田 稔

    小児歯科学雑誌   39 ( 2 )   445 - 445   2001.4

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    DOI: 10.11411/jspd1963.39.2_445

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  • A Method to Divide Gum-chewing Mandibular Movement into its Component Cycles in Children

    IWASE Yoko, HAYASAKI Haruaki, NAKATA Shiho, NAKATA Minoru

    Jpn.j.Ped.Dent.   38 ( 5 )   1025 - 1033   2000.12

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    Since mastication is one of the most important mandibular functions, much attention has been paid to this. Numerous reports, which analyzed this function from the viewpoint of the mandibular movement, have been published on this subject, and the dividing of this masticatory movement into its component cycle has been mandatory in such studies. Although the method to divide these movements greatly influenced the results, less attention has been paid, especially with respect to children with primary dentition. In this study an appropriate method to divide the masticatory movement into component cycles was sought in order to apply this to children.&lt;BR&gt;The subject group for children with primary dentition consisted of 9 girls ranging in age from 4 to 6 years. They were instructed to chew gum. The mandibular movement at the lower incisal point was recorded and analyzed to find the best method for dividing of the chewing movement. First, the best frame for the terminal position of each component cycle was looked for, using two conditions, namely the method to smooth the mandibular movement and a cycle duration. Next, it was examined whether the maximum opening positions, which existed between the terminal positions, would be appropriate. The number of cycles divided from the masticatory movements using these two steps compared with the number of cycles visually recognized as a cycle. In addition,27 women, ranging in age from 16 to 27 years, also participated in this study. Comparison between children with primary dentition and adults with permanent dentition was carried out.&lt;BR&gt;1) More than 99% of the terminal positions were able to be recognized automatically by the smoothing method and minimum cycle duration in children.&lt;BR&gt;2) The same method was applicable to adults with permanent dentition, though the minimum cycle duration was not the same in case of children with primary dentition.&lt;BR&gt;3) Movements, which were not considered as an active chewing cycle could be excludable from the masticatory movement using the condition both of the terminal position and the vertical position of the lower incisal point.

    DOI: 10.11411/jspd1963.38.5_1025

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  • A Method to Divide Gum-chewing Mandibular Movement into its Component Cycles in Children.

    岩瀬陽子, 早崎治明, 中田志保, 中田稔

    小児歯科学雑誌   38 ( 5 )   1025 - 1033   2000.12

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  • Masticatory movements of the mandible around the terminal position in children with primary dentition

    Hayasaki Haruaki, Saitoh Issei, Nakata Shiho, Iwase Youko, Okamoto Atsuyoshi, Yamasaki Youichi, Nakata Minoru

    The Journal of Japanese Society of Stomatognathic Function   6 ( 2 )   153 - 161   2000.8

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    The purpose of this study was to investigate the characteristics of the movement at the lower incisal point around the occlusal phase during gum-chewing movement in children with primary dentition. Mandibular movement was measured using the TRI-MET, which is an opto-electronic analysts system with six degrees-of-freedom at a sampling frequency of 100 Hz. This measurement data was transferred to a graphics workstation via a personal computer and Ethernet. The subjects were categorized according to their age into two groups. The subject group for children with primary dentition consisted of 12 children, 4 boys and 8 girls, ranging in age from 4 to 6 years. These subjects had no dental caries, or had slightly restored teeth, did not have any trouble with, occlusion, or mandibular function, and had no history of orthodontic treatment. The subject group for the adults with permanent dentition consisted of 18 women, ranging in age from 19 to 27 years, and had a normal occlusionwith no history of orthodontic treatment. Each subject was instructed to chew the gum freely from maximum intercuspal position for twenty seconds. The entire chewing movement was divided into cycles at the lower position of the movement to prevent from damaging the occlusal phase. Cycles were classified into four patterns according to their closing and opening pathways. Both closing and opening pathways were classified based on their preferred and non-preferred sides. A three-dimensional velocity curve was estimated by using multilevel model analysis. As a result, the gum-chewing movement in children with primary dentition was characterized as below: 1)80% of cycles were chewed on the preferred side. 2)only 35% of cycles used both preferred side and non-preferred side in children. howeyer, 65% of adults used both sides, 3)the speed in children was faster than in adults, 4)the difference of the velocity between types was smaller than that of between groups. These characteristics might be related to their morphological specific Teature, shallow occlusal relationship, flat occlusal plane and/or shallow fossa and nat eminence relationship of the condyle. (334words)

    DOI: 10.7144/sgf.6.153

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  • Hotz 床が上顎歯槽部および口蓋形態に及ぼす変化について : 口蓋裂単独の場合

    猪之鼻 美和, 渡辺 里香, 落合 聡, 二見 志保, 陣内 みさき, 緒方 哲朗, 早崎 治明, 中田 稔, 中村 典史, 窪田 泰孝, 武田 康男

    日本口蓋裂学会雑誌   25 ( 2 )   211 - 211   2000.5

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  • 小児の開閉口運動と協調する頭部運動 成人との比較

    黒田国康, 山崎要一, 早崎治明, 田中稔

    小児歯科学雑誌   38 ( 2 )   461 - 461   2000.4

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  • 乳歯列期小児のそしゃく終末位におけるこう合接触の解析

    岩瀬陽子, 早崎治明, 岡本篤剛, 中田志保, 中田稔

    小児歯科学雑誌   38 ( 2 )   281   2000.4

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  • 小児のそしゃく運動の終末位付近における開閉口路の解析

    斉藤一誠, 早崎治明, 中田志保, 中田稔

    小児歯科学雑誌   38 ( 2 )   280   2000.4

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  • 乳歯列期小児のガムそしゃく運動の特徴について 新しいサイクル選択方法とMultilevel Model Analysisの応用

    早崎治明, 中田志保, 岡本篤剛, 永田めぐみ, 岩瀬陽子, 山崎要一, 中田稔

    小児歯科学雑誌   38 ( 2 )   279 - 279   2000.4

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  • 歯年齢の発達にともなうそしゃく時の主そしゃく部位の変化

    中田志保, 岩瀬陽子, 渡辺里香, 早崎治明, 岡本篤剛, 中田稔

    小児歯科学雑誌   38 ( 2 )   402   2000.4

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  • 歯年齢の発達にともなう咀嚼時の主咀嚼部位の変化

    中田 志保, 岩瀬 陽子, 渡辺 里香, 早崎 治明, 岡本 篤剛, 中田 稔

    小児歯科学雑誌   38 ( 2 )   402 - 402   2000.4

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    DOI: 10.11411/jspd1963.38.2_402

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  • 乳歯列期小児の開閉口運動経路について

    澤味 規, 早崎 治明, 中田 志保, 中田 稔

    小児歯科学雑誌   38 ( 2 )   462 - 462   2000.4

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    DOI: 10.11411/jspd1963.38.2_462

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  • 小児の開閉口運動と協調する頭部運動 : 成人との比較

    黒田 國康, 山崎 要一, 早崎 治明, 中田 稔

    小児歯科学雑誌   38 ( 2 )   2000.4

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  • 小児の咀嚼運動の終末位付近における開閉口路の解析

    斉藤 一誠, 早崎 治明, 中田 志保, 中田 稔

    小児歯科学雑誌   38 ( 2 )   280 - 280   2000.4

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    DOI: 10.11411/jspd1963.38.2_280

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  • 乳歯列期小児のガム咀嚼運動の特徴について : 新しいサイクル選択方法とMultilevel Model Analysisの応用

    早崎 治明, 中田 志保, 岡本 篤剛, 永田 めぐみ, 岩瀬 陽子, 山崎 要一, 中田 稔

    小児歯科学雑誌   38 ( 2 )   2000.4

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  • 乳歯列期小児の咀嚼終末位における咬合接触の解析

    岩瀬 陽子, 早崎 治明, 岡本 篤剛, 中田 志保, 中田 稔

    小児歯科学雑誌   38 ( 2 )   281 - 281   2000.4

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    DOI: 10.11411/jspd1963.38.2_281

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  • 咀嚼運動における上下の歯のかみ合わせ状態

    早崎 治明

    食生活科学・文化及び地球環境科学に関する研究助成研究紀要   16   47 - 53   2000

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  • ファンクショナル・アプライアンスを使用した咬合誘導

    山崎要一, 渡辺里香, 永田めぐみ, 黒田國康, 佐藤恭子, 早崎治明, 中田稔

    咬合誘導研究会会誌   4 ( 1 )   21 - 24   2000

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  • The Three-dimensional Changes of the Dental Arches and Occlusion in the Treatment of Anterior Crossbite with Primary Dentition.

    肥川員子, 渡辺里香, 早崎治明, 山崎要一, 丸亀知美, 永田めぐみ, 中田稔

    小児歯科学雑誌   37 ( 4 )   716 - 725   1999.9

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  • The Three-dimensional Changes of the Dental Arches and Occlusion in the Treatment of Anterior Crossbite with Primary Dentition

    KOIKAWA Kazuko, WATANABE Rika, HAYASAKI Haruaki, YAMASAKI Youichi, MARUGAME Tomomi, NAGATA Megumi, NAKATA Minoru

    小児歯科学雑誌   37 ( 4 )   716 - 725   1999.9

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  • Development of a System for Analyzing Occlusal Contacts During Lateral Excursions in the Primary Dentition

    OKAMOTO Atsuyoshi, HAYASAKI Haruaki, YAMASAKI Youichi, NAKATA Minoru

    Jpn.j.Ped.Dent.   37 ( 3 )   580 - 589   1999.6

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    The purpose of this study was to investigate occlusal contact relationships during lateral excursions in the primary dentition.&lt;BR&gt;A custom computer system combining lower jaw movement and three-dimensional tooth shape to display tooth contacts during mandibular movements. Lower jaw movement along all 6 degrees of freedom was measured with an opto-electronic movement analysis system at a sampling frequency of 100 Hz. Tooth shape was measured using a three-dimensional digitizer at 0.2 mm intervals. These two sets of measurements were then converted to the same coordinate system in order to establish the three-dimensional relationship between upper and lower occlusal surfaces at any mandibular position. At every mandibular position, the distance between the upper and lower occlusal tables was calculated. Distances of less than 0.2 mm were defined as an area of occlusal contact.&lt;BR&gt;Occlusal contact areas of 5 children (3 boys and 2 girls, with a mean age of 5 year-7 month) were analyzed during lateral excursion using this system. None of the subjects had dental caries. The normal primary occlusion of the children was under continuous oral management in our department.&lt;BR&gt;The results of this preliminary study are as follows:&lt;BR&gt;1. Computer graphics can be used to visually display changing occlusal contact area during lateral excursions in the primary dentition.&lt;BR&gt;2. The occlusal contact area of every tooth can be quantified during lateral excursions in the primary dentition using this system.&lt;BR&gt;3. Our preliminary results indicate that occlusal contact occurs at the primary deciduous second molars on both the working and non-working sides during lateral excursion.&lt;BR&gt;4. Further studies are needed to determine the functional role of these occlusal contacts in the primary dentition.

    DOI: 10.11411/jspd1963.37.3_580

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  • A Study of the Effect of the Eruption and Transition of the First Permanent Molar on the Occlusion, Occlusal Contact Area and Occlusal Force : 2 The Longitudinal Data Analyses

    MASUMOTO Yasuhiro, MORINUSHI Takanobu, OGURA Tadashi, NAGATA Megumi, YAMASAKI Youichi, MINEMATU Kiyohito, FUJISE Takako, HAYASAKI Haruaki, NAKATA Minoru, KUMASAKA Sumio, UCHIMURA Noboru, DOI Masanao, AKASAKA Morito, KARIBE Hiroyuki, OGATA Kiyokazu, KIKUCHI Susumu, NAKASHIMA Midori, MIYAZAWA Hiroo

    Jpn.j.Ped.Dent.   37 ( 3 )   475 - 481   1999.6

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    This study is a part of the study on the development of the occlusal function in children that was carried out by the department of pediatric dentistries of six colleges to examine the longitudinal change regarding the occlusal contact for a period of 2 years starting from around the time of the eruption of the first permanent molar. We examined longitudinally the occlusal contact area, the mean pressure, the occlusal power and the maximum power for the first permanent molar and second deciduous molar in 18 cases using data obtained four times every six month from around the time of the eruption of the first permanent molar. There was consequently a positive correlation between the contact area and each other parameter. The occlusion of the first permanent molar demonstrated maturating with fluctuations in each of the four types of contact area during the examination&#039;s period. It was in the end suggested that the first permanent molar in every type could be obtained finally a stable situation bilaterally with cooperation of the deciduous second molar. One of the types however did not obtain bilateral harmony of the contact area in cooperation with the deciduous second molar with the final data. It was indicated that this case should be further considered to obtain a conclusion. If further follow-up survey for this research can be succeeded, it will provide a more definite conclusion.

    DOI: 10.11411/jspd1963.37.3_475

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  • Development of a System for Analyzing Occlusal Contacts During Lateral Excursions in the Primary Dentition.

    岡本篤剛, 早崎治明, 山崎要一, 中田稔

    小児歯科学雑誌   37 ( 3 )   580 - 589   1999.6

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  • 聖マリア病院における Hotz 型人工口蓋床と口唇癒着術を併用した両側性唇顎口蓋裂症例に対する治療効果について

    落合 聡, 吉川 厚重, 上村 哲司, 柳田 憲一, 江藤 順, 中嶋 敏子, 藤崎 みずほ, 渡辺 里香, 早崎 治明, 武田 康男, 中田 稔

    日本口蓋裂学会雑誌   24 ( 2 )   186 - 186   1999.6

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  • 片側性交叉咬合治療前後の咀嚼運動変化 : 指示側咀嚼達成率の変化

    早崎 治明, BUSCHANG Peter H, THROCKMORTON Gaylord S, 中田 稔

    小児歯科学雑誌   37 ( 2 )   311 - 311   1999.4

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    DOI: 10.11411/jspd1963.37.2_311

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  • Effect of hardness of food on mastication motion ranging from start of chewing to just before swallow - Comparison among deciduous tooth row stage, mixing dentition stage and adult stage.

    中田志保, 早崎治明, 岡本篤剛, 岩瀬陽子, 永田めぐみ, 中田稔

    小児歯科学雑誌   37 ( 2 )   356   1999.4

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  • 食品の硬さが噛み始めから嚥下直前に至る咀嚼運動の変化に及ぼす影響 : 乳歯列期・混合歯列期・成人の比較

    中田 志保, 早崎 治明, 岡本 篤剛, 岩瀬 陽子, 永田 めぐみ, 中田 稔

    小児歯科学雑誌   37 ( 2 )   356 - 356   1999.4

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  • Change in chewing motion after treatment for unilateral cross occlusion - Indication side mastication achievement ratio.

    早崎治明, BUSCHANG P H, THROCKMORTON G S, 中田稔

    小児歯科学雑誌   37 ( 2 )   311   1999.4

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  • Application of Six-Degree-of-Freedom Jaw Movement Tracking Devices for Analysis of Stomatognathic Function in Children

    NAKATA Minoru, YAMASAKI Youichi, HAYASAKI Haruaki

    Nihon Hotetsu Shika Gakkai Zasshi   42 ( 6 )   921 - 927   1998.12

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    Pediatric dentistry comprehensively covers the oral health care through the active period of growth and development in human life cycle. Not only the normal physical growth in the orofacial region, but also the developmental process of stomatognathic function in this period are necessary to clarify it, because the functional development of children is always progressing and leads to the maturation of masticatory function in adulthood. Jaw motion should give a lot of important information about oral function because it is performed by the functional integration of teeth, maxillary and mandibular bones, masticatory muscle, nervous system, and other organs. The application of six-degree-of-freedom jaw movement tracking devices must be the most suitable method to evaluate jaw motion, and to detect in detail the dynamic characteristics of the whole mandibular function. In this study, the application of a few measurement systems to children was discussed including two sets of our systems, and some results on jaw motion analyses of children were presented, 1) Characteristics of mandibular excursion of children, 2) Relationship between occlusal facets and lateral excursions of primary molars, 3) Six year longitudinal changes of jaw tracks of one child, 4) Characteristics of condylar motion during opening-closing movement, 5) Focusing characteristics of the condylar tracks, 6) Design of the curved mesh diagram of mandibular excursion, etc. Jaw motion of children had many different characteristics in comparison with adults.

    DOI: 10.2186/jjps.42.921

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  • Application of Six-Degree-of-Freedom Jaw Movement Tracking Devices for Analysis of Stomatognathic Function in Children.

    中田稔, 山崎要一, 早崎治明

    日本補綴歯科学会雑誌   42 ( 6 )   921 - 927   1998.12

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  • Clinical effects of Hotz plate on the patient of cleft lip and palate

    OCHIAI S, ETO J, FUJISAKI M, WATANABE R, YANAGITA K, HAYASAKI H, TAKEDA Y, NAKATA M

    障害者歯科 = JOURNAL OF THE JAPANESE SOIETY FOR DISABILITY AND ORAL HEALTH   19 ( Suppl. )   365 - 365   1998.8

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  • 反対咬合を有する小児の顎運動の特徴

    永田 めぐみ, 山崎 要一, 早崎 治明, 岡本 篤剛, 中田 志保, 中田 稔

    小児歯科学雑誌   36 ( 2 )   1998.4

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  • 小児の口輪筋の強さについての研究 : 成人との比較

    片渕 桂子, 石井 光治, 早崎 治明, 一村 智美, 渡辺 里香, 山崎 要一, 中田 稔

    小児歯科学雑誌   36 ( 2 )   1998.4

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  • 小児における下顎側方滑走運動時の顆頭移動の特徴

    岩瀬 陽子, 早崎 治明, 山崎 要一, 中田 志保, 岡本 篤剛, 中田 稔

    小児歯科学雑誌   36 ( 2 )   1998.4

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  • Bite Force and Occlusal Condition in Children Measured During Dental Checkups in Schools

    OKUSHI Kanako, NISHIJIMA Norihiro, HAYASAKI Haruaki, INAMI Toru, NAKATA Minoru

    小児歯科学雑誌   36 ( 1 )   65 - 70   1998.3

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  • Bite Force and Occlusal condition in Children Measured During Dental Checkups in Schools.

    大串香奈子, 西嶋憲博, 早崎治明, 居波徹, 中田稔

    小児歯科学雑誌   36 ( 1 )   65 - 70   1998.3

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  • 顎機能異常を有する小児の顆頭運動について

    山崎要一, 早崎治明, 岡本篤剛, 中田志保, 永田めぐみ, 西嶋憲博, 中田 稔

    咬合誘導研究会会誌   2 ( 1 )   28 - 29   1998

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  • Effect of food texture on masticatory movement in children

    S Nakata, H Hayasaki, M Nakata

    JOURNAL OF DENTAL RESEARCH   77   876 - 876   1998

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  • Excursive condylar kinematics of unilateral posterior crossbite patients.

    PH Buschang, A Santos-Pinto, GS Throckmorton, H Hayasaki

    JOURNAL OF DENTAL RESEARCH   77   1019 - 1019   1998

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  • A Study on the Mandibular Movement During the Masticatory Process in Children

    NAKATA Shiho, HAYASAKI Naruaki, NISHIJIMA Norihiro, NAKATA Minoru

    小児歯科学雑誌   35 ( 5 )   783 - 789   1997.12

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  • Three Dimensional Treatment Changes of the Maxillary and Palate on Deciduous Crossbite

    MARUGAME Tomomi, HAYASAKI Haruaki, WATANABE Rika, FUJISAKI Mizuho, YAMASAKI Youichi, NAKATA Minoru

    Jpn J Ped Dent   35 ( 5 )   790 - 798   1997.12

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  • A Study on the Mandibular Movement During the Masticatory Process in Children.

    中田志保, 早崎治明, 西嶋憲博, 中田稔

    小児歯科学雑誌   35 ( 5 )   783 - 789   1997.12

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  • Three Dimensional Treatment Changes of the Maxillary and Palate on Deciduous Crossbite.

    丸亀知美, 早崎治明, 渡辺里香, 藤崎みずほ, 山崎要一, 中田稔

    小児歯科学雑誌   35 ( 5 )   790 - 798   1997.12

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  • 咀嚼運動時の上下の歯の接触滑走範囲に関する研究

    早崎 治明

    日本咀嚼学会雑誌   7 ( 2 )   89 - 89   1997.12

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  • A study on concordance between intercuspal position and terminal position of masticatory movement in children

    Nakata Shiho, Hayasaki Haruaki, Nakata Minoru

    The Journal of Japanese Society of Stomatognathic Function   4 ( 1 )   31 - 36   1997.8

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    Masticatory movement in children and adults has been studied from several perspective. The movement around the terminal position of mastication in children is a matter that is still not well understood. The purpose of this study was to clarify the concordance between the intercuspal position and the terminal position of chewing movement in children. We divided the subjects into three groups according to dental age:primary dentition group (5 boys, 1 girl); early mixed dentition group (4 boys, 3 girls);and permanent dentition group (9 women). The lower incisal point and the working and non-working condyles were used as reference points for tridimensional tracking. The concordance of these reference points was evaluated by calculating the distance between the intercuspal and terminal positions of mastication. Chewing gum was used as food sample for this study. At the lower incisal point, the distance between the intercuspal and terminal positions decreased with dental age. Moreover, the primary dentition group had the largest distance in the anterior-posterior direction in three directions. At the condyles as well, the distance between the intercuspal and terminal positions decreased with dental age. Furthermore, for the early mixed dentition group, the movement resembled that of the permanent dentition group. The underlying reason for these findings may be physiological growth, maturation, and adaptation of the occlusal function.

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  • A study on the reproducibility and stability of terminal position of masticatorty movement in children

    Hayasaki Haruaki, Nakata Shiho, Nishijima Norihiro, Okamoto Atsuyoshi, Yamasaki Youichi, Nakata Minoru

    The Journal of Japanese Society of Stomatognathic Function   4 ( 1 )   25 - 30   1997.8

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    The purpose of this study was to determine the stability of the terminal point of chewing movement in children. The subjects were divided in three groups:the primary dentition group which consisted of six subjects (5 boys, 1 girl);the early mixed dentition group which consisted of seven subjects (4 boys, 3 girls), and the permanent dentition group consisting of nine women. Chewing gum was chosen as the experimental foodstuff, and chewing cycles were recorded from each subject. The lower incisal poing and the working and non-working condyle were selected as reference movement points and tracked tridimensionally in six degrees of freedom with the TRIMET system. The most superior measuring point of each cycle was recognized as the terminal position of the masticator cycle. The standard deviation (SD) of 10 cycles from each subject, regarded as an index of stability, was calculated and compared between groups. Results:The SD was highest in the primary dentition group, and smallest in the permanent dentition group. In all groups, the SD of right and left directions was largest in three directions at the lower incisal points, and the anteroposterior direction was largest in both condyles. The lower incisal point&#039;s SD of the early mixed dentition group was similar to that of the primary dentition group, and the condyles&#039; similar to the permanent dentition group.

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  • The effect of a bionator on the volume changes of the proper oral cavity in the treatment of Class II malocclusion

    YAMASAKI Youichi, HAYASAKI Haruaki, NISHIJIMA Norihiro, NAGATA Megumi, NAKATA Minoru

    7 ( 1 )   25 - 33   1997.7

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  • 小児の集団歯科検診における咬合力および咬合接触状態の調査結果

    大串 香奈子, 西嶋 憲博, 早崎 治明, 居波 徹, 中田 稔

    小児歯科学雑誌   35 ( 2 )   320 - 320   1997.4

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    DOI: 10.11411/jspd1963.35.2_320

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  • 小児の下顎滑走運動時おける上下歯牙間距離の変化について

    岡本 篤剛, 早崎 治明, 西嶋 憲博, 中田 志保, 山崎 要一, 中田 稔

    小児歯科学雑誌   35 ( 2 )   201 - 201   1997.4

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    DOI: 10.11411/jspd1963.35.2_201

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  • 小児の下顎切歯点における咀嚼運動終末位の安定性に関する研究

    早崎 治明, 中田 志保, 西嶋 憲博, 岡本 篤剛, 山崎 要一, 中田 稔

    小児歯科学雑誌   35 ( 2 )   1997.4

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    DOI: 10.11411/jspd1963.35.2_203

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  • 小児における咀嚼の進行に伴う下顎運動の変化

    中田 志保, 早崎 治明, 西嶋 憲博, 岡本 篤剛, 山崎 要一, 中田 稔

    小児歯科学雑誌   35 ( 2 )   202 - 202   1997.4

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    DOI: 10.11411/jspd1963.35.2_202

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  • Research on stability of terminal place of mastication motion in incisal point of infantile lower jaw.

    早崎治明, 中田志保, 西嶋憲博, 岡本篤剛, 山崎要一, 中田稔

    小児歯科学雑誌   35 ( 2 )   203 - 203   1997.4

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  • Changes in mandibular movement with progress of infantile mastication.

    中田志保, 早崎治明, 西嶋憲博, 岡本篤剛, 山崎要一, 中田稔

    小児歯科学雑誌   35 ( 2 )   202 - 202   1997.4

  • Survey results of bite force and occlusion contact conditions of infants in a group dental check up.

    大串香奈子, 西嶋憲博, 早崎治明, 居波徹, 中田稔

    小児歯科学雑誌   35 ( 2 )   320 - 320   1997.4

  • Investigation of the relationship between the curved mesh diagram of mandibular excursion and the occlusal phase of mastication

    Hayasaki Haruaki, Nakata Shiho, Yamasaki Youichi, Nishijima Norihiro, Okamoto Atsuyoshi, Minematsu Kiyohito, Nakata Minoru

    The Journal of Japanese Society of Stomatognathic Function   3 ( 2 )   147 - 152   1997.1

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    The aim of this study was to develop a method to measure the range of the mandible during the occlusal phase of mastication. The mandibular movement of one healthy male subject(age 25 yrs), with normal occlusion, was measured with an opto-electronic motion analysis system(TRIMET, Tokyo shizaisha, Tokyo, Japan). This system is able to measure mandibular motion with six degrees of freedom, and has a sampling frequency of 100 Hz. the subject was initially instructed to perform mandibular excursive movements, with tooth contact, on 4 occasions each lasting 30 seconds. Thus 12, 000 positions of the mandible were obtained. From this a three-dimensional curved mesh diagram of mandibular excursion was constructed for the mandibular incisal point which extended 15 mm anteriorly, 13 mm posteriorly(x axis), and 14 mm to the left and to the right(y axis), with intercuspal position at the origin with the resolution of 0.1 mm. To determine the supero-inferior position(z axis)of this mesh, the 12, 000 mandibular positions were searched and, if two or more z values corresponded to a single x-y coordinate, the z value closest to the horizontal plane was chosen. In addition, this curvilinear mesh deiagram could be constructed for any mandibular landmark. A masticatory cycle(for chewing gum)from the subject was compared to this mesh diagram. Coincidence between this cycle and the mesh indicated occlusal contact during mastication, and for this subject contact was observed for a distance of 3.8 mm(opening phase: 3.4 mm; closing phase: 0.4 mm). The curved mesh diagram of mandibular excursion enabled visualization of excursive movements of any point on the mandible, and is useful in examining and understanding the mandibular function.

    DOI: 10.7144/sgf.3.147

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  • A Study of The Effect of The Eruption of The First Permanent Molar To Occlusion, Contact Area and Occlusal Force : 1 The Analysis of The First Examination

    NAGATA Megumi, YAMASAKI Youichi, MINEMATU Kiyohito, FUJISE Takako, HAYASAKI Haruaki, NAKATA Minoru, TOYOSHIMA Syouzaburo, OGURA Tadashi, UCHIMURA Noboru, DOHI Masanao, AKASAKA Morito, KARIBE Hiroyuki, OGATA Kiyokazu, KIKUCHI Susumu, NAKASHIMA Midori, MIYAZAWA Hiroo

    小児歯科学雑誌   34 ( 5 )   1171 - 1180   1996.12

  • The crown diameter and dental arch size of primary dentition in Indonesian Javanese children

    INDIARTI Ike Siti, YAMASAKI Youichi, HAYASAKI Haruaki, NAKATA Minoru

    Pediat Dent J   6 ( 1 )   9 - 17   1996.7

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  • 第一大臼歯の萌出、咬合推移と咬合接触面積および咬合力の変化 : 第1報 初回採得資料の分析結果について

    永田 めぐみ, 山崎 要一, 峰松 清仁, 藤瀬 多佳子, 早崎 治明, 中田 稔, 豊島 正三郎, 小椋 正, 内村 登, 土肥 順尚, 赤坂 守人, 苅部 洋行, 小方 清和, 菊池 進, 中島 みどり, 宮沢 裕夫

    小児歯科学雑誌   34 ( 2 )   1996.4

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  • 健全歯列を有する小児のIIC期からIIIC期にわたる下顎滑走運動の経年的変化を追った一症例

    岡本 篤剛, 西嶋 憲博, 早崎 治明, 中田 志保, 峰松 清仁, 山崎 要一, 中田 稔

    小児歯科学雑誌   34 ( 2 )   1996.4

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  • 小児における咬頭嵌合位付近の咀嚼運動経路と側方滑走運動経路の一致性について

    中田 志保, 早崎 治明, 西嶋 憲博, 岡本 篤剛, 山崎 要一, 中田 稔

    小児歯科学雑誌   34 ( 2 )   1996.4

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  • 口唇口蓋裂患児に対するHotz型人工口蓋床の効果 : 片側性唇顎口蓋裂に関して

    江藤 順, 藤崎 みずほ, 早崎 治明, 平野 洋子, 武山 康男, 落合 聡, 中田 稔

    小児歯科学雑誌   34 ( 2 )   1996.4

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  • 小児の咀嚼筋活動と下顎運動の関連性に関する研究 : 第2報 乳歯列期小児の咀嚼パターンの相違と咀嚼筋活動の特徴について

    石井 光治, 山崎 要一, 早崎 治明, 永田 めぐみ, 中田 稔

    小児歯科学雑誌   34 ( 2 )   1996.4

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  • A Study of Three-dimensional Condylar Movement in Children : In the Cases of Protrusive Mandibular Excursions

    NISHIJIMA Norihiro, HAYASAKI Haruaki, YAMASAKI Youichi, NAKATA Minoru

    小児歯科学雑誌   33 ( 5 )   985 - 994   1995.12

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  • A Study of Three-dimensional Condylar Movement in Children. In the Cases of Protrusive Mandibular Excursions.

    西嶋憲博, 早崎治明, 山崎要一, 中田稔

    小児歯科学雑誌   33 ( 5 )   985 - 994   1995.12

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  • Practical application of computer aided simulation in occlusal guidance.

    中田稔, 早崎治明, 西嶋憲博, 峰松清仁, 山崎要一

    Quintessence   14 ( 7 )   1695 - 1702   1995.7

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  • An Investigation on the Patients Records of the First Visit in Pediatric Dental Clinic of Kyushu University Dental Hospital

    NAGATA Megumi, TANAKA Katsuaki, HAYASAKI Hasuaki, WATANABE Rika, YAMASAKI Youichi, NAKATA Minoru

    Jpn.j.Ped.Dent.   33 ( 3 )   543 - 551   1995.6

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    Language:Japanese   Publisher:The Japanese Society of Pediatric Dentistry  

    The purpose of this investigation was to gain insight into the actual condition of patients who visited the Pediatric Dental Clinic of Kyushu University Dental Hospital during the period from April 1979 to March 1993. The subjects were 6229 children (3107 boys and 3122 girls).&lt;BR&gt;The findings were as follows:&lt;BR&gt;(1) As for the age of the patients at the first visit,2 year-old and 3 year-old patients represented a large percentage (26.2%).&lt;BR&gt;(2) As for the chief complaint, the complaint of dental caries was the most frequent, followed by malocclusion, trauma, oral check up and soft tissue disease. However, the rate of dental caries decreased every year while that of the other complaints increased.&lt;BR&gt;(3) As for the number of patients who were referred to our clinic, patients from private general dental clinics were the most numerous, followed by those from Kyushu University Medical Hospital, friends, The Oral Surgery Clinic of this hospital as well as the staff of this hospital and general hospitals. The number of these patients increased every year and has occupied over 55% of all patients sinse 1991.&lt;BR&gt;(4) The rate of patients afflicted with other than dental diseases or handicapped patients was 20.4%. Most of them were from Kyushu University Medical Hospital. The number of the patients from general hospitals has increased rapidly every year.&lt;BR&gt;(5) 61.18% of all patients had experienced dental treatment before they visited our clinic. Most of the patients with malocclusion as the chief complaint had experienced dental treatment before, while most of the patients who came for oral chek up or whose chief complaint was soft tissue diseases had no such experience.

    DOI: 10.11411/jspd1963.33.3_543

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  • 小児の顆頭部三次元動態に関する研究 : 第1報 下顎前方滑走運動時について

    西嶋 憲博, 早崎 治明, 山崎 要一, 中田 稔

    小児歯科学雑誌   33 ( 2 )   1995.4

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    DOI: 10.11411/jspd1963.33.2_269

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  • 小児のか頭部三次元動態に関する研究 第1報 下顎前方滑走運動時について

    西嶋憲博, 早崎治明, 山崎要一, 中田稔

    小児歯科学雑誌   33 ( 2 )   269   1995.4

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  • 歯年齢2A,3Aおよび成人における側方滑走運動の比較

    早崎 治明

    小児歯科学雑誌   30 ( 1 )   270 - 270   1992.3

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  • A research of relationship between protrusive excursion of mandible and the overlap of frontal teeth in children

    Hayasaki Haruaki, Yamasaki Youichi, Naruse Katsuko, Ogata Tetsurou, Ishii Mitsuharu, Nakata Minoru

    Proceeding of Japanese Society of Stomatognathic Function   11   139 - 142   1992

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    Language:Japanese   Publisher:Japanese Society of Stomatognathic Function  

    DOI: 10.7144/sgf1982.11.139

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  • The stomatognathic function in a case of hemifacial hypertrophy-Findings of mandibular movement.

    山崎要一, 早崎治明, 緒方哲朗, 中田稔, 浜野良彦

    小児歯科学雑誌   29 ( 1 )   186 - 195   1991.3

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  • A resarch of children's mandibular excursion : An analysis protusive excursion

    Hayasaki Haruaki, Yamasaki Youithi, Nakata Minoru

    Proceeding of Japanese Society of Stomatognathic Function   10   87 - 90   1991

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    Language:Japanese   Publisher:Japanese Society of Stomatognathic Function  

    DOI: 10.7144/sgf1982.10.87

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  • 小児の下顎運動に関する研究(第5報) 歯牙年齢2Aと3Aの滑走運動の比較

    早崎 治明

    小児歯科学雑誌   28 ( 3 )   878 - 878   1990.9

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  • Three-dimensional change of the occlusal facets in primary dentition before and after the eruption of first permanent molars.

    竹中稔, 山崎要一, 緒方哲朗, 小田博, 早崎治明, 阿部和久, 中田稔

    小児歯科学雑誌   28 ( 2 )   313 - 326   1990.6

  • 小児の下顎運動に関する研究 (第4報) 乳歯列・永久歯列における側方滑走運動の比較

    早崎治明, 山崎要一, 中田稔

    小児歯科学雑誌   27 ( 3 )   816 - 816   1989.9

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Research Projects

  • 再植歯の人為的髄床底穿孔と神経伝達シグナル調節による歯髄再生療法の開発

    Grant number:23K09411

    2023.4 - 2026.3

    System name:科学研究費助成事業

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    大島 邦子, 大島 勇人, 早崎 治明, 佐野 拓人

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    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

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  • The mechanism of oral pressure formation in developmental process of feeding function after weaning

    Grant number:22K10267

    2022.4 - 2025.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

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  • 早産児の口腔発達支援プログラムの開発

    Grant number:21K10901

    2021.4 - 2025.3

    System name:科学研究費助成事業 基盤研究(C)

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    松原 まなみ, 早崎 治明, 中村 由紀

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    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    本研究の目的は、早産児の『口腔機能発達支援プ ログラム』を作成し,有効性を検証することである。
    『口腔機能発達支援プ ログラム』の作成に先立ち、1)早産児の口腔機能発達の実態調査として、2021 年度には、(1)質問紙調査による実態調査を予定していた。また、今年度の経費執行計画では、2年目以降に計画していた2)早産児の吸啜・咀嚼機能の運動生理学的分析で使用予定の(1)咀嚼運動の動作解析用機器、および、(2)吸啜運動の動画解析用の計測機器の購入を計画していた。しかしながら、協力施設がCOVID-19蔓延防止法/緊急事態宣言対象地域(福岡、東京)にあり、予備調査や打ち合わせができない状況が続いたこと、さらに、本研究の対象者である乳幼児にオミクロン株が流行したことから、調査協力の内諾は得られたにもかかわらず、調査開始の見通しがたたないまま、今日に至っている。このような状況下で、2021年度に予定していた計画は大幅に遅れ、2022年度も現地フィールドでのデータ収集実施の見通しが不透明なことから、2022年度以降に予定していた研究の内容を、研究目的の達成に必要な項目に厳選し、研究計画の見直しを行った。(研究計画の変更に関しては、「今後の研究の推進方策」で述べる。)
    また、2023年度に計画していた(2)乳児の吸啜運動の動画解析(舌運動の超音波映像解析)に関して、 年度の科研で購入した機器を活用する予定であったが、前任地からの計測機器の移管ができない状況が判明した。そのため、2)早産児の吸啜・咀嚼機能の運動生理学的分析については、咀嚼機能の分析に焦点化し、吸啜運動の分析は、調査項目から除外することとした。

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  • 外傷歯における神経伝達シグナルと人為的血流調節による歯髄静的幹細胞賦活化の試み

    Grant number:20K10224

    2020.4 - 2023.3

    System name:科学研究費助成事業 基盤研究(C)

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    大島 邦子, 大島 勇人, 早崎 治明

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    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    小児の歯の完全脱臼における第一選択は再植だが,歯根完成歯では再植後の歯髄再生は期待できず,長期保存の保証はない.我々はこれまで,マウスの歯を再植前に歯根短縮術を施すと,歯髄内に早期の血行回復がおこり,歯髄静的幹細胞の活性化を促すことを明らかにした.しかし,歯根短縮術は根尖部歯髄に存在する幹細胞群SCAPを失うこと,また歯根が短いことは歯の長期予後を悪化させることから,歯根短縮術を行わずに,早期の血行回復と歯髄幹細胞の賦活化を惹起する方法として以下の実験を考案し,実施した.
    ①再植時の髄床底部への意図的穿孔形成
    深麻酔下で3週齢マウス上顎右側第一臼歯を抜去後,髄床底に直径0.5mmのカーバイドバーで穿孔形成し,抜歯窩に再植した.術後3日~8週まで継時的にマウスを麻酔下で灌流固定し,歯髄治癒過程を解析した.その結果,対照群に比較し,実験群では穿孔部から早期の血行回復が起こり,術後3~5日の歯髄内アポトーシスの減少と細胞増殖活性の増加を促進し,術後2週の実験群の再植歯遠心根でNestin陽性率が有意に増加し,歯冠部の第三象牙質形成が増加した.従って,髄床底部への意図的穿孔形成が髄床底部からの早期の血行回復を促し,歯髄静的幹細胞を賦活し,歯の再植後の歯髄治癒を促進することが示唆された.しかし,今回の実験では髄床底穿孔部での骨形成・アンキローキスが惹起され,7日後のマラッセの上皮遺残の有意な減少を伴った.
    ②再植歯のβ3アドレナリン受容体作動薬溶液への浸漬
    Hanks液にイソプロテレノールを5~20%の濃度で添加した溶液に,抜去歯を5分間浸漬後に再植し,2週後の治癒過程を解析した.その結果,有意差はないものの,Hanks液のみの対照群に比較して,10%実験群でNestin陽性率が高い傾向がみられた.すなわち,歯髄治癒が促進する可能性が示唆された。

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  • Exploring effective methods for reducing dental treatment loads during home visit dentistry.

    Grant number:19K10223

    2019.4 - 2022.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Kon Haruka

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    This study investigates the postures of both patients in wheelchairs and dentists while performing at-home dental treatment with the aim to detect effective conditions in which both participants feel less load. We set several conditions during simulated dental treatment home visits. Postures were recorded using an optical 3D motion analysis device.
    Patient backbend angles without a headrest were greater than with a headrest. Consequently, without the presence of a headrest, a patient’s head and neck muscles need to be constantly active. Therefore, patients’ head and neck muscle fatigue might be reduced by the use of headrests. Furthermore, while performing dental treatment for patients in wheelchairs, dentists’ forward bending angles of the trunk and upper arm elevation angles were greater in comparison to normal dental treatment conditions. Accordingly, for dentists, performing dental treatment on patients in wheelchairs is more difficult than in normal conditions.

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  • Risk evaluation of food suffocation from feature analysis of food capturing and processing in children

    Grant number:19K10402

    2019.4 - 2022.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Nakamura Yuki

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    Understanding the refinement of self-feeding skills is useful for the assessment of oral functional development in children. To determine normative data on lip closing during food intake in the development of independent spoon-feeding in normal children, we tested the hypothesis that lip-closing pressure and spoon operation differ depending on food type. Lip-closing force and spoon operation varied depending on food type in preschool and early elementary school children compared to adult. Our findings suggest the need to consider the importance of food diversity when assessing the development and maturation of lip function.

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  • Food intake motion affects tooth erupting timing.

    Grant number:19K10379

    2019.4 - 2022.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    HAYASAKI HARUAKI

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    The background of this study is that the eruption time of primary teeth in Japan tends to be "earlier for anterior and later for molars", and this tendency is observed in developed countries such as the United States, but not in developing countries. It can be understood that tooth eruption timing is related to feeding behavior.
    Continuous measurement in children could not be performed because of the spread of coronavirus infection, especially for children. We intend to continue measurements in children as soon as the epidemic is under control, thereby achieving the objective of this research project. In this study, we investigated the lip function, which is closely related to the tooth eruption of children, and found that the lip function of children during feeding was different from that of adults.

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  • Elucidation of mechanisms maintaining the homeostasis of quiescent periodontal stem cells demonstrated by tooth germ transplantation

    Grant number:17K11953

    2017.4 - 2021.3

    System name:Grants-in-Aid for Scientific Research

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Nakakura-Ohshima Kuniko

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    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    In order to search the dynamics of periodontal ligament stem cells, we conducted a tooth germ transplantation experiment using mice. Since periodontal ligament stem cells cannot be labeled by the BrdU labeling method, stem cells/progenitor cells were labeled by administering doxycycline to the pregnant mother on 14.5 days of embryonic period. As a result, 25.0% of the transplanted tooth germs were found to have both odontoblast differentiation and root formation, and some specimens were erupted and occluded. Strongly GFP-positive cells, which are considered to be static stem cells, were maintained in the center of the pulp or the sub-odontoblastic layer, and differentiate into odontoblasts, whereas strongly GFP-positive cells were not found in the periodontal ligament. These results suggest that GFP-positive periodontal ligament stem cells maintained during tooth development are affected by allogenic tooth germ transplantation.

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  • 歯胚移植を応用した歯根膜静的幹細胞の恒常性維持機構の解明

    2017.4 - 2020.3

    System name:基盤研究(C)

    Awarding organization:日本学術振興会

    大島 邦子

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    Grant type:Competitive

    Grant amount:\360000 ( Direct Cost: \300000 、 Indirect Cost:\60000 )

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  • Improvement of lip closure strength cures its masticatory motion

    Grant number:16K11802

    2016.4 - 2019.3

    System name:Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Hayasaki Haruaki

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    Authorship:Principal investigator  Grant type:Competitive

    T he improvement of the oral function was observed by performing training to improve the lip closure strength in children with deep overbite, anterior crossbite, crowding, open bite, and maxillary protrusion. However, anterior crossbite and open bite gave priority to improvement of the removal the oral habits, including the weak lip closure strength, it was effective to perform training of the lip closure strength at first. Consequently, the improvement of the lip closure strength normalized the chewing motion.
    The results of our study provides basic information concerning oral health promotion during childhood.

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  • Body posture influences the mandibular and head movements during feeding.

    Grant number:15K11193

    2015.4 - 2018.3

    System name:Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Satoh Naoko

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    Grant type:Competitive

    We analyzed the feeding movements of oral cavity using a motion capture, when subjects chewed food with various kinds of posture and when a meal was provided from various kinds of directions during assisted feeding. It was suggested that the posture of the body affects the chewing motion, and that the head posture and then the food-intake movement of mouth come under an influence of the direction of feeding assistance. We note that attention on food-intake and mastication is required during management of posture and an assistance method during feeding.

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  • Effects of root resection and antibacterial drugs on the pulpal and periodontal tissue healing following tooth replantation

    Grant number:26463111

    2014.4 - 2018.3

    System name:Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Nakakura-Ohshima Kuniko

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    Grant type:Competitive

    This study aimed to analyze the effects of the enlarged apical foramina on the pulpal healing process using a model for tooth replantation/transplantation. After the extraction of ICR or GFP mouse teeth, the tooth roots from the experimental group were shortened before replantation/transplantation, whereas in the control group the teeth were immediately replanted. The occurrence of abundant tertiary dentin formation was observed in the resected teeth, whereas, divergent healing patterns including dentin, bone, and fibrous tissues were observed in the control group. Tooth transplantation using GFP or wild-type mice demonstrated that the root resection accelerated the revascularization and donor-derived odontoblast-like cell differentiation, resulting in the rapid pulpal healing. In conclusion, the root resection accelerates the dental pulp regeneration following tooth replantation/transplantation due to the better environment for revascularization in the replants.

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  • Effect of taste stimulation into pharynx on swallowing in the developmental process

    Grant number:26463108

    2014.4 - 2017.3

    System name:Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Nakamura Yuki

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    Grant type:Competitive

    Chemical stimulation of the pharynx is effective in eliciting swallowing. We investigated the effect of taste solutions on the elicitation of swallowing in human. The results indicated that stimulation of the pharyngeal region with sour solutions facilitates swallowing, suggesting that the facilitation may be due to increases of sensory inputs. Moreover, we tested in anesthetized or unanethetized rats whether there were particular neuron activities in cortical area and brain stem during feeding by using multi-channel neural recordings and stimulation applications.

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  • The excessive inspiration negative pressure of upper airway ventilation obstructed children makes mandible retreat -Using fluid structure interaction analysis

    Grant number:26670889

    2014.4 - 2016.3

    System name:Grant-in-Aid for Challenging Exploratory Research

    Research category:Grant-in-Aid for Challenging Exploratory Research

    Awarding organization:Japan Society for the Promotion of Science

    Yamasaki Youichi

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    Grant type:Competitive

    This study examined the influence of the negative pressure of the airway on mandibular retraction during inspiration of children with nasal obstruction.
    Sixty-two children were divided into Class I, II, and III groups. Airflow pressure was simulated using computational fluid dynamics to calculate nasal resistance and airway pressure during inspiration and expiration. Nasal resistance of the Class II group was significantly higher than that of the other two groups, and oropharyngeal airway inspiration pressure in the Class II (-247.64 Pa) group was larger than that in the Class I (-43.51 Pa) and Class III (-31.81 Pa) groups (P < 0.001). Airway inspiration-expiration pressure difference in the Class II (-27.38 Pa) group was larger than that in the Class I (-5.17 Pa) and Class III (0.68 Pa) groups (P = 0.006). Large negative inspiratory airway pressure due to nasal obstruction in children with Class II malocclusion may be related to their retrognathia.

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  • Behavior management by Nitrous oxide inhalation and Dexmedetomidine-containing Lidocaine

    Grant number:25463176

    2013.4 - 2017.3

    System name:Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Saitoh Yoko

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    Grant type:Competitive

    We planned to use Nitrous oxide inhalation and Dexmedetomidine-containing Lidocaine in this research and to manage behavior by sedative effect thought as a side effect and a demerit. To secure safety was the absolute condition in this research. It was very important how to monitor vital signs such as subject's breathing and circulation. And to perform blood pressure measurements on continuous occasions was so difficult for special needs persons and noncooperative children. To secure safety was the dominate the agenda until induction of sedation and it was impossible to warranty of sure safety in a like way of healthy adults.

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  • Motion Analysis of Food Intake during Weaning Period

    Grant number:25463174

    2013.4 - 2016.3

    System name:Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Hayasaki Haruaki

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    Authorship:Principal investigator  Grant type:Competitive

    Food intake during weaning period has been paid little attention. However, this motion may be crucial for the development of oral morphology and function. Three-dimensional measurement and analysis of this motion was performed, however, children of this period were too young as subjective person to obtain the precise data. Their food intake motions consisted of the backward tilting motion of the head rather than the downward motion of the mandible.
    Measurement of the motion of the mandible during mastication from female adults revealed that the weight of the subjective foods affected the entire cycle time and ranges along three orthogonal axes.

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  • The comprehensive studies that an airway ventilation disorder and hyperplasia of palatine tonsil give to chewing and the deglutition function of children

    Grant number:25293420

    2013.4 - 2016.3

    System name:Grant-in-Aid for Scientific Research (B)

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    Yamasaki Youichi

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    Grant type:Competitive

    When the mouth serves as not only the chewing but also the respiratory function and has a chronic nose disease, a large burden has both chewing and respiration, and the influence on chewing function is expected.
    We evaluated airway ventilation condition, hyperplasia of palatine tonsil, lingual movement at deglutition to clarify the influence that an airway ventilation disorder and hyperplasia of palatine tonsil gave to chewing, the deglutition of children in this study.As a result, it was, and, as for the tongue, anteposition was able to clarify what lingual movement influenced by the amount at the deglutition of the water when a tongue became the low position when there was an airway ventilation disorder, and there was hyperplasia of palatine tonsil.

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  • Relationship of pharyngeal airway respiration pressure on anteroposterior skeletal patterns of children: A CFD study of expiration and inspiration

    Grant number:25670878

    2013.4 - 2015.3

    System name:Grant-in-Aid for Challenging Exploratory Research

    Research category:Grant-in-Aid for Challenging Exploratory Research

    Awarding organization:Japan Society for the Promotion of Science

    Iwasaki Tomonori

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    Grant type:Competitive

    Introduction: The pharyngeal airway inspiration pressure may influence maxillofacial form. This study tested the null hypothesis that pharyngeal airway respiration pressures in children with malocclusion due to different anterior-posterior skeletal patterns do not differ. Methods: Sixty-two average-FMA-angle children were divided into Class I, Class II, and Class III malocclusion groups. Cone-beam computed tomography data was used to reconstruct 3-dimensional shapes of the nasal and pharyngeal airways. Airflow pressure was simulated using computational fluid dynamics to calculate the pharyngeal airway pressure during inspiration. Results: The pharyngeal airway inspiration pressure in the Class II (-247.64 Pa) group was larger than that in the Class I (-43.51 Pa) and Class III (-31.81 Pa) groups. Conclusion: The large negative inspiratory pharyngeal airway pressure due to nasal obstruction in Class II children is related to their retrognathia.

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  • Establishment of effective sucking and oral function for cleft lip and palate infants

    Grant number:24390502

    2012.4 - 2017.3

    System name:Grant-in-Aid for Scientific Research (B)

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    Matsubara Manami

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    Grant type:Competitive

    Cleft lip and palate infants usually used Hotz plate to assist their sucking function. To provide effective sucking and development of mastication and swallowing function, we improved the Hotz plate, developed a special shaped feeding bottle, brought about new breastfeeding technique. We sat up a hypothesis that improved Hotz formed a small cavity (called sucking fossa) more activate sucking movement .The tongue movements of twelve infants were recorded under two conditions, with normal Hotz and with improved Hotz by an ultrasonic apparatus. The movements were processed by DIPP Motion Pro to draw as waveforms. Displacement were measured in all subjects. The displacement was 23.4±0.9 in improved Hotz while 24.7±2.27 in normal Hotz. It indicated the tongue movement in improved was significantly greater than normal. Since tongue movement was deeply related to lip, jaw movement and oral function, the result implied development of those functions as well as effective sucking.

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  • Collection and Construction of database for physiological and physical support of children

    Grant number:24390463

    2012.4 - 2016.3

    System name:Grant-in-Aid for Scientific Research (B)

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    Fujiwara Taku

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    Grant type:Competitive

    The purpose of this study is to analyze the data of patients’ background using machine learning method and to develop an application that could output helpful information. We also tried to construct a new system that will enable to continuously collect and utilize these data using tablet. We included data collection system of dental trauma.
    Data collection system was completed. We will continue data collection using this system.
    We tried to make decision tree from questionnaire of the mother class using application Weka (Machine Learning Group at the University of Waikato, New Zealand) . Several decision trees were generated, but we could not obtain proper decision trees according with the conventional theory. Since the contents of the sheet were slightly different at each clinic, missing values were likely to influence the analysis. A unified questionnaires style would be necessary. In addition, selection of the objective variable should be more important.

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  • Construction of the airway obstruction evaluation system of the childhood sleep apnea syndrome using Fluid-structure analysis

    Grant number:24659914

    2012.4 - 2014.3

    System name:Grant-in-Aid for Challenging Exploratory Research

    Research category:Grant-in-Aid for Challenging Exploratory Research

    Awarding organization:Japan Society for the Promotion of Science

    Yamasaki Youichi

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    Grant type:Competitive

    Obstructive sleep apnea syndrome (OSAS) in children is not rare and is a major health problem. Unfortunately, surgery's success rate is not always high because obstruction sites of the upper airway vary considerably. Morphological findings from computed-tomography (CT) do not always coincide precisely with the functional obstruction sites in the upper airway. Consequently, establishing a method to detect the specific obstruction sites of the whole upper airway is indispensable to successful treatment of OSAS. We examined the obstruction sites in an upper airway model of a OSAS child by fluid-structure interaction (FSI) analysis.
    We established a new method combining an airway model with FSI analysis. This method can locate the obstruction sites and simulate the magnitude of air pressure and velocity, evaluating the ventilation condition more precisely than with a morphological evaluation alone.

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  • Elucidation of the role of dental pulp stem cells and Wnt signaling during pulpal formation demonstrated by tooth germ transplantation

    Grant number:23593026

    2011.4 - 2015.3

    System name:Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Nakakura-Ohshima Kuniko

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    Grant type:Competitive

    The goal of this study is to characterize the healing of allogenic tooth grafts in an animal model using GFP-labeled donor or host postnatal mice. In addition, the putative stem cells were labeled before transplantation with a pulse-chase paradigm. Transplanted molars formed cusps and roots and erupted into occlusion by 2 wk postoperatively. Donor label-retaining cells (LRCs) were maintained in the center of pulp tissue associating with blood vessels. Dual labeling showed that a proportion of LRCs were incorporated into the odontoblast layer. Host cells, including putative dendritic cells and the endothelium, also immigrated into the pulp tissue but did not contribute to the odontoblast layer. Therefore, LRCs or putative mesenchymal stem cells are retained in the transplanted pulps. Thus, the dynamic donor-host interaction occurred in the developing transplant, suggesting that these changes affect the characteristics of the dental pulp.

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  • Effect of the antineoplastic agent busulfan on rat molar root development

    2011.4 - 2014.3

    System name:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Mitomi Tomoe

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    Grant type:Competitive

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  • Enrichment of the tooth constitution cell derived from human iPS cells using an original technique

    2011.4 - 2014.3

    System name:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Hasegawa Hiroko

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    Grant type:Competitive

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  • Effect of the antineoplastic agent busulfan on rat molar root development

    Grant number:23593024

    2011 - 2013

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    TOMOE MItomi, KAWANO Yoshiro, MAEDA Takeyasu, HAYASAKI Haruaki

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    Grant amount:\5070000 ( Direct Cost: \3900000 、 Indirect Cost:\1170000 )

    The antineoplastic bifunctional-alkylating agent busulfan (Bu) induces developmental anomalies of the teeth. The aims of this study were to clarify the effect of the administering Bu at different stages of rat molar root development. The rats receiving Bu at an early stage showed osteodentin formation and complete destruction of the Hertwig's epithelial root sheath (HERS). The root lengths in rats treated with an early stage were lower than that in the control rats. A narrowed apical foramen and an increased amount of osteodentin were also present, depending on the rat's age at the time of treatment. Busulfan treatment in rats resulted in abnormal root development, depending on the stage at which Bu was administered. The administration of Bu caused a shortage of HERS cells, which are required for normal root development. This disturbs root formation, resulting in osteodentin formation and a narrowed apex foramen.

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  • Enrichment of the tooth constitution cell derived from human iPS cells using an original technique

    Grant number:23593038

    2011 - 2013

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    HASEGAWA Hiroko, SATO Masahiro, SAITOH Issei, YAMASAKI Youichi, HAYASAKI Haruaki, NOGUCHI Hirofumi

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    Grant amount:\5070000 ( Direct Cost: \3900000 、 Indirect Cost:\1170000 )

    We obtained a primary culture of teratoma cells from a nude mouse that was transplanted with a pT-ARIP introduced in an iPS cell. We attempted to detect cells responsible for tooth development based on the expression of the fluorescent gene; however, the cells were not detected.. In the process in which a teratoma was formed, repression of gene expression likes gene silencing may have started the introduced gene. Hence, RT-PCR analysis of the primary teratoma cell culture obtained from iPS cells before transgenesis was conducted. The expression of OCT3/4, NANOG, NESTIN, OC (osteocalcin), DMP, DSPP, and BGP was observed. Moreover, the existence of AMELX was confirmed by immunohistological analysis.

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  • Biomechanical properties of human primary enamel derived the fracture toughness -comparative study of permanent enamel-

    Grant number:22592279

    2010.4 - 2014.3

    System name:基盤研究(C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Hayashi-Sakai Sachiko

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    Grant type:Competitive

    The purpose of the present study was to examine the fracture toughness and Vickers microhardness number of permanent and primary human enamel using the indentation microfracture method. Crack resistance and a parameter indirectly related to fracture toughness were measured in 48 enamel specimens from 16 permanent teeth and 12 enamel specimens obtained from six primary teeth.
    The Vickers microhardness number of the middle portion was greater than the upper portion in primary enamel. The fracture toughness was highest in the middle portion of permanent enamel, because fracture toughness greatly depends upon microstructure. These findings suggest that primary teeth are not miniature permanent teeth but have specific and characteristic mechanical properties.

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  • Hypothesis: Feeding behavior is conjectured from occlusal condition.

    2010.4 - 2013.3

    System name:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Hayasaki Haruaki

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    Authorship:Principal investigator  Grant type:Competitive

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  • Identification of ventilation obstructionsite of OSAS of children by the fluid simulation and construction of the treatment predictive model

    Grant number:22592292

    2010.4 - 2012.3

    System name:Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Iwasaki Tomonori

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    Grant type:Competitive

    The fluid mechinical simulation (FMS) was shown to be effectiveto detect a site of the upper airway obstruction. When we planned OSAS treatment, we proved efficacy of the combination of FMS and CBCT to diagnose the obstruction of the upper airway. And we evaluated the effect to nasal cavity ventilation, tongue posture, the pharynx airway volume of the maxillary rapid expansion (RME). RME enlarged pharynx airway with or without the improvement of the nasal cavity aeration state. This effectis effective for OSAS of children. We consider that the above-mentioned results help the construction of the future treatment predictive model.

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  • A ventilation function of the three-dimensional lumenairway form by the fluid simulation technique and allied evaluation of the jaw occlusion state

    Grant number:22390392

    2010.4 - 2012.3

    System name:Grant-in-Aid for Scientific Research (B)

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    Yamasaki Yoichi

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    Grant type:Competitive

    The fluid simulation technique was able to evaluate a ventilation condition of the three-dimensional lumen airway. Specifically, we were shown to be effective in the detection of the ventilation obstruction site of the upper airway. Furthermore, the evaluation of the partial ventilation condition of the upper airway was possible, and this method was able to confirm the improvement situation of the nasal cavity ventilation condition by the maxillary rapid expansion. Also, we evaluated a ventilation condition of dolichofacial type and brachyfaicial type of Class II by this method, and upper respiratory tract aeration disorder was able to show that maxillofacial vertical growth and association were deep. We were able to show that a ventilation disorder of the upper airway was associated with maxillofacial vertical growth.

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  • Hypothesis: Feeding behavior is conjectured from occlusal condition.

    Grant number:22592291

    2010 - 2012

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    HAYASAKI Haruaki, HASEGAWA Hiroko, IWASAKI Tomonori, YAMASAKI Youichi, SAITOH Issei

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    Because the chewing motion dramatically changes by the occlusal condition, the relationship may hold among three developmental factors: "feeding behavior ⇔ chewing motions ⇔ occlusal condition". From results of analyzing feeding behaviors and chewing motions, smaller within-individual variations, compared to between-individual variations, were observed in adults. On the other hand, it is well knownthat occlusal condition is dominated by lip closure pressure, tongue motion and masticatory muscles even in younger children. The establishment of stable motions with smaller within-individual variations is affected by these elements. Therefore it might be suggested that the occlusal condition also affectedfeeding behaviors.

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  • Fluid mechanical study of the airway of the child and the maxillofacial form using CBCT

    Grant number:19592360

    2007.4 - 2009.3

    System name:Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Iwasaki Tomonori

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    Grant type:Competitive

    This study established a system of ventilation condition and the obstruction site specification from a nose to a throat using CT data. From the system, (1) The Class III malocclusion is associated with shape of the oropharyngeal airway. (2) Most dolichofacial children with a Class II malocclusion have an obstructed upper airway. (3) It was useful for a diagnosis and treatment of OSAS and the upper airway obstruction of the maxillofacial malformation person.

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  • Protrusion and retrusion are dominant mandibular movements during nursing. How long do these movements continue

    2007.4 - 2009.3

    System name:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Hayasaki Haruakai

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    Authorship:Principal investigator  Grant type:Competitive

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  • An epidemiological survey about the prevalence of congenitally missing permanent teeth of Japanese children

    Grant number:19390532

    2007.4 - 2008.3

    System name:Grant-in-Aid for Scientific Research (B)

    Research category:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    Yamasaki Youichi

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    Grant type:Competitive

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  • Protrusion and retrusion are dominant mandibular movements during nursing. How long do these movements continue

    Grant number:19592357

    2007 - 2008

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    HAYASAKI Haruaki, YAMAMOTO Shinya, INADA Emi

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    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

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  • Functional food physics by using multi-body system.

    2005.4 - 2007.3

    System name:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Hayasaki Haruaki

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    Authorship:Principal investigator  Grant type:Competitive

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  • Functional food physics by using multi-body system.

    Grant number:17592141

    2005 - 2006

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    HAYASAKI Haruaki

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    Grant amount:\3700000 ( Direct Cost: \3700000 )

    Although "maintenance of the masticatory function" is hung up in "Healthy Japan 21" as one of the targets which should be attained, it is exactly a reason that this has high correlation in elderly people's digestion and the physical action of the whole body. It being required, when considering acquisition and recovery of a normal masticatory function and performing medical treatment and rehabilitation using food or an auxiliary implement is what kind of movement being performed for every food, and clarifying what kind of load (effort) being required. The child and elderly people of low age are especially asked for application of the "functional physical properties" of food. Although some standards exist in and outside the country about selection of subjective food, these are classified as mechanical physical properties of foods in many cases, and are not in agreement with the case where it actually digests after cooking, in many cases. Moreover, subjective foods were selected by using overseas literature to reference, in order to avoid food unique to Japan. However, the definition of "functional physical properties" is attained only after the functional data and masticatory efficiency which were acquired from these living bodies are connected organically. Moreover, it is indispensable for visualizing it to connect physical properties to a function (movement and line activity). Then, a multi-body system analysis and integrated IDL analysis were introduced. The special feature of this research grazes the load in the masticatory movement in fixed quantity functionally, and was clinical very interesting. Since it was enabled to acquire the diagnostic method and to carry out a simulation as a result of this research, the meaning of this research is large. While many results were obtained as follows, it is also a fact that many questions which should be solved from now on newly blew off, and the further development is desired that clinical application of the system and result which were obtained by this research from now on should be carried out more.

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  • The development of the diagnostic system of the dynamic function in patients with jaw deformity by using three dimensional MRI.

    2004.4 - 2007.3

    System name:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Goto Tazuko

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    Grant type:Competitive

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  • 顎変形症患者の顎口腔機能三次元統合解析システムの構築

    Grant number:16659573

    2004.4 - 2005.3

    System name:萌芽研究

    Research category:萌芽研究

    Awarding organization:日本学術振興会

    中島 昭彦

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    Grant type:Competitive

    外科矯正治療を必要とする患者に対しては、形態異常部位の特定やその程度を知ることを目的として通常の不正咬合者の検査と同じく頭部エックス線規格写真や歯列模型の検査が行われるが、それに加えて全身麻酔下での大掛かりな手術を受けることからComputed Tomography (CT)が撮影される。またこのような重症の顎顔面形態異常患者には種々の顎口腔機能異常が付随していることが考えられるため術前後の機能検査が必須となっているが、両者をまとめた形態と機能の総合的解析システムはまだ報告されてはいない。本研究は患者の顎顔面形態をコンピュータ画面上に三次元で表示し、それを機能検査データに基づいてアニメーションで動かす顎口腔機能の三次元解析システムを構築するとともに、その結果を患者へのインフォームドコンセントにおける分かり易いコミュニケーションツールとして利用することを目的として開始した。
    平成17年度は、まず正・側方頭部エックス線規格写真の二次元画像から頭部形態の三次元画像を構築する方法とその画像に歯列画像を合体させる方法を報告した(文献1)。一方、口腔内に設置したセラミック真球を媒体として、立体構築したCT(3D-CT)に歯列三次元画像と咀嚼筋MRI画像や顔表面画像を組み入れる方法と、それらの顎変形症患者への応用について報告した(文献1)。現在、三次元頭部画像に顎運動および顎関節動態を表示するシステムについて日本顎変形症学会雑誌とAmer J Orthod & Orthopに投稿中であり、前者は採択が決定している。論文のほかにもここまでの成果は平成17年度に開催された日本矯正歯科学会と日本顎変形症学会にそれぞれ2題ずつ発表しており、前者の学会発表「顎変形症における顎顔面骨格および咀嚼筋形態の三次元的評価」には優秀発表賞が授与されている。

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  • The development of the diagnostic system of the dynamic function in patients with jaw deformity by using three dimensional MRI.

    Grant number:16591887

    2004 - 2006

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    GOTO Tazuko K., HAYASAKI Haruaki, TOKUMORI Kenji, NAKASHIMA Akihiko, NAKAYMA Eiji, YOSHIURA Kazunori

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    Grant amount:\3500000 ( Direct Cost: \3500000 )

    1. Three-dimensional morphology.
    (1) Jaw bone : We decided the most appropriate sequence of MRI for jaw bone. The accuracy of the 3D MRimages of dry mandible in vitro was similar to that from CT. We therefore perform the investigation of the jaw in vivo.
    (2) Masticatory muscles : In patients, a comparison of deviated and non-deviated sides showed, in orientation, differences for masseter and medial pterygoid muscles, but in size, differences only for the masseter muscle. Nevertheless, muscle sizes in patients were much smaller than in controls. Lateral displacement of the mandible can explain the orientation differences, but not the smaller muscle size, in patients.
    (3) Temporomandibular joint : The TMJ on the deviated side showed a smaller condyle.
    2. Three dimensional function
    (1) TMJ : The TMJ on the deviated side showed a higher incidence of disk displacement than the non- deviated side and those in the controls. However, the clinical symptoms showed no differences between the deviated and non-deviated sides, and no association with disk displacement.
    (2) Occlusal force : There was no significant difference in the balance of the occlusal contact area and the occlusal force between the right and left sides in the controls, while the balance was shifted to the deviated side in the patients. It is therefore considered important to establish and maintain adequate occlusion through appropriate orthodontic treatment to improve the orthognathic function in patients.
    3. We developed the diagnostic system of the dynamic function in patients with jaw deformity by combining the morphology data and functional data.

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  • The functional analysis of mandibular movements and bite force using the dentofacial model of children

    2003.4 - 2006.3

    System name:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Yamasaki Youichi

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    Grant type:Competitive

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  • The functional analysis of mandibular movements and bite force using the dentofacial model of children

    Grant number:15592168

    2003 - 2005

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    YAMASAKI Youichi, HAYASAKI Haruaki, ISHITANI Norihito, SAITOH Issei

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    Grant amount:\3600000 ( Direct Cost: \3600000 )

    The analyzed parameters for the research of "The functional analysis of mandibular movements and bite force using the dentofacial model of children" were below,
    1.A new way of analyzing occlusion three-dimensionally was developed.
    2.Occlusal glide movements of the terminal phase during mastication were analyzed in detail.
    3.Mandibular movements such as protrusion, habitual mouth opening and closing movements, and mastication of anterior reverse bite children were analyzed.
    4.Biomechanical effects of changes in the mandibular morphology on the temporomandibular joint, Part 1. Condylar displacement, and Part 2. Disc displacement, were analyzed.
    5.Many articles and books related to the subject of this research were presented.
    The detailed results were described on the research articles which were inserted in the undermentioned list of references.

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  • ヒト家族性・非家族性骨格性反対咬合における早期診断法開発に関する分子遺伝学的研究

    Grant number:15659494

    2003 - 2004

    System name:科学研究費助成事業 萌芽研究

    Research category:萌芽研究

    Awarding organization:日本学術振興会

    佐々木 康成, 早崎 治明, 落合 聡

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    Grant amount:\3200000 ( Direct Cost: \3200000 )

    本研究の目的は、骨格性不正咬合の早期診断を可能にし、治療方針や予後を確かに推察するために、被検者に負担なく簡便にDNAを抽出する方法を確立し、さらに下顎骨の過成長に関与する遺伝子を明らかにすることである。そこで、昨年度に引き続き、(1)小児児歯科臨床において頭部X線規格写真より骨格性反対咬合と診断された患児とその家族について、家族歴の有無に分類し、対照として、咬合に異常のない個性正常咬合の患児を選出し、リストを作成した。(2)上記リストのうち、保護者から同意の得られた69名の患児およびその家族について、来院日において、それぞれ頬粘膜内側を、cytologyブラシ(Scientific Products, Romulus, MI)を用いて擦った。それよりDNAを抽出後、吸光度計を用いて核酸濃度を算出し、DNA増幅(PCR)に使用できることを確認した。今年度は特に、下顎枝の成長に影響を及ぼすことが示唆されている候補遺伝子の一つであるGHR(Growth Hormone Receptor)遺伝子のPro561Thr変異をもつExon10について、特異的プライマーを用いて増幅した。さらに、PCR RFLP法を用いて、Pro561Thrの変異の有無を調べた。そして、得られた遺伝子の変異の有無と、頭部X線規格写真の分析値、特に下顎骨の過成長との間の関連性について検索した。結果、69名の被験者のうち、9名にPro561Thrの変異が認められたが、反対咬合の有無や、下顎骨の大きさを表すパラメーターとの有意な統計学的関係は認められなかった。しかし、外胚葉異形成症を有する一患児の下顎枝長を含めた下顎骨の計測項目が標準値と比較して大きい原因を調べる目的で、GHRのPro561Thrの変異の有無を調べた。結果、変異は認められず、この患児の特異的な下顎骨の形態が、遺伝子型により裏づけられた。この症例については、ケースレポートとして、論文提出中である。

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  • Research of the occlusal phase during the masticatory movement

    2000.4 - 2003.3

    System name:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Hayasaki Haruaki

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    Authorship:Principal investigator  Grant type:Competitive

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  • Research of the occlusal phase during the masticatory movement

    Grant number:12672004

    2000 - 2002

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    HAYASAKI Haruaki, OCHIAI Satoru, YAMASAKI Youichi

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    Grant amount:\3100000 ( Direct Cost: \3100000 )

    The purposes of this study were 1) to establish the system, which could observe the occlusal contacts and the length of the glide during functional masticatory movements, and 2) to investigate the characteristics of the occlusal phase during chewing movements. The system has been built and reported in 2000 (J Dent Res, 79: 1890-1895). Also several characteristics of chewing movements in children with primary dentition compare with adults with healthy permanent dentition has been reported in 2000, 2001 and 2002 by means of this system (J Jpn Soc Stomatognath Funct, 6: 153-161, 2000; Jpn J Ped Dent, 38, 1025-1033, 2000; J Oral Rehabil, 28, 328-334, 2001; J Oral Rehabil, 29, 64-71, 2002). To elucidate the characteristics of occlusal phase in children, 1) the length of occlusal glides, 2) the stability of this length, 3) the stability of the position of the minimum opening position, 4) the stability of the maximum intercuspal position, 5) the sagittal and frontal projected angles both on the closing and opening pathway of masticatory cycles, and 6) correlations between the opening and closing pathways were examined.
    As results, 1) children with primary dentition had less variability on almost all variables, 2) chewing pattern was not the same between two groups, and 3) adults had relatively high correlations between the opening and closing pathway compared with children. These results might be caused by 1) relatively flat occlusal morphology including dentitions and TMJ, and 2) imprinted sucking behavior might exist even in children with primary dentition. Some finding suggested that these characteristics would be decreasing with their growth and development.
    This study could provide good information for the characteristics of the occlusal phase in children with primary dentition. However, further investigation will be required to obtain the clues for the functional diagnosis of the mandible.

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  • The research of the influence of mastication on general health from the view of brain function

    1997.4 - 2001.3

    System name:Grant-in-Aid for Scientific Research (B)

    Awarding organization:Japan Society for the Promotion of Science

    Nakata Minoru

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    Grant type:Competitive

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  • The research of the influence of mastication on general health from the view of brain function

    Grant number:09470473

    1997 - 2000

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B).

    Research category:Grant-in-Aid for Scientific Research (B).

    Awarding organization:Japan Society for the Promotion of Science

    NAKATA Minoru, HAYASAKI Haruaki, YAMASAKI Youichi, FUJISE Takako

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    Grant amount:\11500000 ( Direct Cost: \11500000 )

    One of the main goals of dentistry is to achieve lifelong health of the masticatory function. Until very recently, however, the influence and significance of mastication on the global health of the human body have remained uncertain. The purpose of this study is to clarify the relationship between mastication and general health.
    In the basic study, it was indicated that brain histamine function activated by mastication began earlier in the mesencephalic trigeminal nucleus and later in the ventromedial hypothalamic nucleus, the satiety center, due to a signal originating from the oral proprioceptors and initiated by chewing. And it was suggested the difference of oral proprioceptive sensation originated from food consistency and its signal procession in the hypothalamus caused the changes in energy balance that affects adiposity.
    In the clinical study, the changes of chewing movement in the process of mastication of jelly with different texture were compared between children and adults. The new method was developed for easy visualization and diagnosis of mandibular movement measured by an opto-electonic movement analysis system. The measurement system that combined a tracking system for mandibular movements with a three-dimensioned digitizer for tooth shape was developed to record occlusal contacts during mandibular movement. Incisal and condylar paths during habitual mouth opening movement of children with anterior reverse bite in the primary dentition compared to those of children with normal dentition. These findings indicate that mastication is of great importance not only for the intake of food but also for the systemic and physical functions.

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  • 咀嚼が心身の発達に及ぼす影響を中枢メカニズムから解明する研究

    1995.4 - 1997.3

    System name:基盤研究(C)

    Awarding organization:日本学術振興会

    中田 稔

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    Grant type:Competitive

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  • The effect to masticatory development by mandibular movement and blood flow

    1995.4 - 1997.3

    System name:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Hayasaki Haruaki, Yamasaki Youichi

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    Authorship:Principal investigator  Grant type:Competitive

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  • 小児反対咬合の機能的特徴の検索に関する研究

    1995.4 - 1996.3

    System name:奨励研究(A)

    Awarding organization:日本学術振興会

    早崎 治明

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    Authorship:Principal investigator  Grant type:Competitive

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  • S STUDY ON THE EFFECT OF CHEWING UPON THE PHYSICAL & MENTAL DEVELOPMENT FROM THE CENTRAL NEURAL SYSTEM

    Grant number:07838024

    1995 - 1996

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    NAKATA Minoru, FUJISE Takako, HAYASAKI Haruaki, NONAKA Kazuaki

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    Grant amount:\2600000 ( Direct Cost: \2600000 )

    Latest studies have shown the relationship between mastication and general health. We previously reported brain histamine modulates satiation through the ventromedial hypothalamic nucleus and masticatory function through the mesencephalic trigeminal nucleus. To examine the involvement of mastication to general health, we measured the physiological feeding behavior of the WKA rats fed with pellets or liquid diet in the circadian analyzing box illuminated daily from 0800 to 2000 h (a 12 : 12-h light-dark cycle). The following parameters mentioned below were evaluated : a size of the meal with food and liquid diet, water intake, activity and caloric intake calculated from meal size in both light- and dark-period. The telemetry rats were surgically implanted with transmitters which measured activity, temperature and heart rate. Variables, temperature and heart rate, before and after a spontaneous feeding were compared between two groups. There were no difference of the increases of body weight between two groups during the experiment period. The caloric intake in light period increased in the rats fed liquid diet compared to that of the rats fed with pellets. The average temperature in the liquid diet group were higher than that in the pellet group in both light- and dark-period. While the temperature increased in the pellet group in 30 min after initiation of feeding, it once decreased in 15 mine and then increased in 30 min after initiation of feeding in the liquid diet group. The heart rate increased in 15 min after start of feeding in both groups.
    These findings suggest that pellets and liquid diet which have the different food consistency suppose to induce different oral sensation at the mastication and have different effects on the digestive process and metabolism in rats.

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  • The effect to masticatory development by mandibular movement and blood flow

    Grant number:07838026

    1995 - 1996

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    HAYASAKI Haruaki

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    Grant amount:\2300000 ( Direct Cost: \2300000 )

    The research summary was as follows ;
    (1) With use of a Selspot system, the protrusive and lateral excursions of nine children with the primary dentition and nine adults with the permanent dentition were measured and compared. It was found that the excursions of the primary dentition can move more horizontally and more forward with small descent compared with the permanent dentition. The underlying reason for these findings may be physiological growth, maturation, and adaptation of the occlusal function.
    (2) The aim of this study was to estimate dynamic characteristics of passive and active muscle tensions, tensions in the oblique ligament of the TMJ and condylar forces during simulated midline jaw opening and closing in children. The simplified active tension curve for each muscle was modeled by a trigonometric function Y=A^<**>sin (2pi^<**> B^<**> (t-C) 2), in which A represented the EMG amplitude, B the cycle duration, and C the onset time. Midline jaw opening and closing (maximum interincisal distance 10mm, cycle duration 0.8s), were simulated according to jaw motion data from the same child. During the opening phase, tensions of 3N in the digastric muscle and 7N in the inferior head of lateral pterygoid muscle were necessary to open the jaw 10mm. In all mandibular elevator muscles during the closing phase, passive tensionsless than 3N occurred at the beginning of closing phase. There was no tension in the oblique ligament during function. The condylar force increased up to 7N at the end of jaw opening, decreasing to about 1N during jaw closing.
    (3) The purpose of this study was to exactly estimate the volume changes of the proper oral cavity before and after treatment for Angle's Class II malocclusion using a bionator. The cephalometric analyzes revealed a decrease in the ANB angle, an increase in the SNP angle, a lingual inclination of the maxillary central incisor and a labial inclination of the mandibular central incisor after treatment. The dimensional analyzes of the study models showed that the inter-molar width increased while, in contrast, both the overbiteand overjet decreased. The volume of the proper oral cavity was measured by the non-contact three-dimensional measuring system. Both the maxillary part and the mandibular part of the proper oral cavity as well as the total volume of that increased by 20% after treatment.

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  • 小児反対咬合の機能的特徴の検索に関する研究

    Grant number:07772030

    1995

    System name:科学研究費助成事業 奨励研究(A)

    Research category:奨励研究(A)

    Awarding organization:日本学術振興会

    早崎 治明

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    Grant amount:\900000 ( Direct Cost: \900000 )

    本研究の目的は小児の反対咬合の機能的特徴を検索することであり、そのために(1)総合的な計測システム,(2)その結果を客観的に把握できるようなシステムの構築ならびに(3)反対咬合,正常な咬合を有する小児の計測を行ないその機能的な特徴の評価および比較を行なうことを予定した。以下その達成度について報告する。
    (1)下顎運動計測装置や歯冠形態計測装置など複数の現有設備と本研究費で購入したIndy(SiliconGraphics社製)とをEthernetで接続し,Indy上で情報を一元管理し,(2)のシステムが可能となった。
    (2)AVS(Application Visualizing System)とGL(SiliconGraphics Graphic Library)を利用して,下顎運動軌跡や咬合接触状態を表示することができ,現在外来患者の保護者等への治療の説明やインフォームド・コンセントを得るために使用している。この一部は論文として既に報告している(11.研究発表中)。
    (3)反対咬合患者では,下顎が咬合の終末位において上顎前歯により前方に誘導されることが考えられ,その特徴は下顎顆頭部の動きに表れると思われた。そのため比較の対象となる下顎顆頭部の運動の正常像を歯年齢別に明らかにすることを優先的に行ない,論文として報告した(11.研究発表中)。また,いくつかの症例については計測を行ない,その特徴については(2)文中の論文中に報告した。
    上記のようにシステムの構築は当初の予定通り行なえたが,研究の途中で下顎顆頭部の動きを調べる必要が生じたため,最終目的である反対咬合の機能的特徴の検索は症例数がやや少なく,明確な結論は出せていない。今後この点を明確にし,予防的な治療の必要性が論ぜられる方向で研究を継続する予定である。

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Teaching Experience (researchmap)

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Teaching Experience

  • 「食べる」

    2021
    Institution name:新潟大学

  • 成育歯科学IIB

    2021
    Institution name:新潟大学

  • 成育歯科学IB

    2021
    Institution name:新潟大学

  • 臨床歯学コースワーク(小児歯科関係コースワークII)

    2021
    Institution name:新潟大学

  • 臨床歯学コースワーク(小児歯科関係コースワークI)

    2021
    Institution name:新潟大学

  • 成育歯科学IIA

    2021
    Institution name:新潟大学

  • 成育歯科学IA

    2021
    Institution name:新潟大学

  • 障害者歯科学

    2020
    Institution name:新潟大学

  • 齲蝕学

    2020
    Institution name:新潟大学

  • 臨床歯学コースワーク(小児歯科関係コースワークⅠ)

    2018
    Institution name:新潟大学

  • 臨床歯学コースワーク(小児歯科関係コースワークⅡ)

    2018
    Institution name:新潟大学

  • 成育歯科学ⅡA

    2018
    Institution name:新潟大学

  • 成育歯科学ⅠA

    2017
    -
    2018
    Institution name:新潟大学

  • 成育歯科学ⅠB

    2017
    Institution name:新潟大学

  • 統合科目Ⅱ

    2016
    -
    2019
    Institution name:新潟大学

  • 口腔機能管理学

    2016
    -
    2018
    Institution name:新潟大学

  • 臨床予備実習

    2016
    Institution name:新潟大学

  • 臨床歯科学Ⅳ

    2015
    -
    2016
    Institution name:新潟大学

  • 歯科臨床概論

    2015
    -
    2016
    Institution name:新潟大学

  • 「食べる」

    2012
    -
    2020
    Institution name:新潟大学

  • 早期臨床実習ⅠB

    2012
    -
    2014
    Institution name:新潟大学

  • 小児歯科学

    2011
    Institution name:新潟大学

  • 成長発育学

    2011
    Institution name:新潟大学

  • 歯学研究入門

    2011
    -
    2017
    Institution name:新潟大学

  • 早期臨床実習Ⅱ

    2011
    -
    2016
    Institution name:新潟大学

  • 早期臨床実習Ⅰ

    2011
    -
    2016
    Institution name:新潟大学

  • 臨床歯科学Ⅱ

    2011
    -
    2014
    Institution name:新潟大学

  • 臨床歯科学Ⅲ

    2011
    -
    2014
    Institution name:新潟大学

  • 食=「人」に「良」

    2011
    Institution name:新潟大学

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