Updated on 2024/03/29

写真a

 
MORO Hiroshi
 
Organization
University Medical and Dental Hospital Division of Infection Control and Prevention Associate Professor
Title
Associate Professor
External link

Degree

  • 博士(医学) ( 2002.3   新潟大学 )

Research Interests

  • 鉄代謝

  • バイオマーカー

  • 呼吸器内科学

  • 呼吸器感染症

  • 感染症内科学

  • 深在性真菌症

  • HIV感染症

  • 抗酸菌感染症

Research Areas

  • Life Science / Infectious disease medicine

  • Life Science / Respiratory medicine

Research History (researchmap)

  • Niigata University   Medical and Dental Hospital Division of Infection Control and Prevention   Associate Professor   病院教授

    2023.6

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    Country:Japan

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  • Niigata University   University Medical and Dental Hospital Division of Infection Control and Prevention   Associate Professor

    2017.7 - 2023.5

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    Country:Japan

    Notes:副部長

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  • Niigata University   University Medical and Dental Hospital Medical Laboratory Division   Assistant Professor

    2012.7 - 2017.6

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  • Niigata University   University Medical and Dental Hospital Internal Medicine II   Specially Appointed Assistant Professor

    2011.11 - 2012.6

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  • Niigata University   University Medical and Dental Hospital Intensive Care Unit   Assistant Professor

    2010.5 - 2011.10

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Research History

  • Niigata University   University Medical and Dental Hospital Division of Infection Control and Prevention   Associate Professor

    2017.7

  • Niigata University   University Medical and Dental Hospital Medical Laboratory Division   Assistant Professor

    2012.7 - 2017.6

  • Niigata University   University Medical and Dental Hospital Internal Medicine II   Specially Appointed Assistant Professor

    2011.11 - 2012.6

  • Niigata University   University Medical and Dental Hospital Intensive Care Unit   Assistant Professor

    2010.5 - 2011.10

Education

  • Niigata University   Faculty of Medicine

    1989.4 - 1995.3

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    Country: Japan

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Professional Memberships

  • JAPANESE SOCIETY FOR INFECTION PREVENTION AND CONTROL

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  • THE JAPANESE SOCIETY FOR TUBERCULOSIS

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  • THE JAPANESE RESPIRATORY SOCIETY

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  • JAPANESE SOCIETY OF CHEMOTHERAPY

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  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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  • THE JAPANESE ASSOCIATION FOR INFECTIOUS DISEASES

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  • THE JAPANESE SOCIETY FOR AIDS RESEARCH

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Studying abroad experiences

  • University of California, San Diego  

    2005.1 - 2007.7

Qualification acquired

  • 日本内科学会認定内科医/総合内科専門医

  • 日本感染症学会認定専門医/指導医

  • 日本呼吸器学会専門医/指導医

  • 抗菌化学療法指導医

  • ICD

 

Papers

  • Bacterial profiles detected in ventilator-associated pneumonia in Japan: A systematic review Reviewed

    Hiroshi Moro, Nobumasa Aoki, Hiroyuki Matsumoto, Kazuya Tone, Hisayuki Shuto, Kosaku Komiya, Toshiaki Kikuchi, Nobuaki Shime

    Respiratory Investigation   62 ( 3 )   365 - 368   2024.5

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.resinv.2024.01.012

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  • Carbapenem vs. non-carbapenem antibiotics for ventilator-associated pneumonia: A systematic review with meta-analysis. Reviewed International journal

    Hisayuki Shuto, Kosaku Komiya, Kazuya Tone, Hiroyuki Matsumoto, Hiroshi Moro, Nobuaki Shime

    Respiratory investigation   62 ( 2 )   200 - 205   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Carbapenem is recommended as one of the first-line regimens for ventilator-associated pneumonia (VAP), but no recent systematic review has fully investigated its efficacy. This systematic review aims to evaluate the efficacy of carbapenem compared with non-carbapenem for VAP treatment. METHODS: We performed a systematic review and meta-analysis of studies comparing the efficacy and the safety between carbapenem and non-carbapenem with activity to Pseudomonas aeruginosa in the treatment for VAP. The main outcome was mortality, and the additional outcomes were the clinical cure of pneumonia, length of intensive care unit stay, recurrence, adverse effects, and the development of resistant bacteria. This study was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. RESULTS: Of the initial 1,730 publications, 9 randomized control trials were enrolled. In the meta-analysis, no difference was observed between the carbapenem and non-carbapenem regimens in improving mortality (odds ratio, 0.83; 95 % confidence interval (CI) 0.67-1.02). While the carbapenem regimen was superior to the non-carbapenem regimen in studies reporting the resolution of pneumonia (odds ratio, 1.09; 95 % CI 1.01-1.17), the effectiveness of carbapenem treatment was not evident in studies assessing the other outcomes. CONCLUSIONS: Carbapenem might have no superiority in survival when treating VAP. Moreover, non-carbapenem antibiotics with activities to P. aeruginosa have a potential option to avoid inducing carbapenem-resistant pathogens.

    DOI: 10.1016/j.resinv.2023.12.006

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  • Dynamics of iron metabolism in patients with bloodstream infections: a time-course clinical study Reviewed International journal

    Hiroshi Moro, Yuuki Bamba, Kei Nagano, Mariko Hakamata, Hideyuki Ogata, Satoshi Shibata, Hiromi Cho, Nobumasa Aoki, Mizuho Sato, Yasuyoshi Ohshima, Satoshi Watanabe, Toshiyuki Koya, Toshinori Takada, Toshiaki Kikuchi

    Scientific Reports   13 ( 1 )   2023.11

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    The close relationship between infectious diseases and iron metabolism is well known, but a more detailed understanding based on current knowledge may provide new insights into the diagnosis and treatment of infectious diseases, considering the growing threat of antibiotic-resistant bacteria. This study investigated adult patients with bloodstream infections, temporal changes, and relationships between blood levels of iron and related markers, including hepcidin and lipocalin-2 (LCN2). We included 144 samples from 48 patients (mean age 72 years, 50% male), with 30 diagnosed with sepsis. During the acute phase of infection, blood levels of hepcidin and LCN2 increased rapidly, whereas iron levels decreased, with values in 95.8% of cases below the normal range (40–188 μg/dL). Later, hepcidin and LCN2 decreased significantly during the recovery phase, and the decreased iron concentrations were restored. In the case of persistent inflammation, iron remained decreased. Acute LCN2 levels were significantly higher in patients with sepsis (p < 0.01). Hypoferremia induced by increased hepcidin would reduce iron in the environment of extracellular pathogens, and the increased LCN2 would inhibit siderophores, resulting in the prevention of the pathogen’s iron acquisition in each manner during the acute phase of bloodstream infection.

    DOI: 10.1038/s41598-023-46383-7

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    Other Link: https://www.nature.com/articles/s41598-023-46383-7

  • Virological outcomes of various first-line ART regimens in patients harbouring HIV-1 E157Q integrase polymorphism: a multicentre retrospective study Reviewed

    Shunsuke Uno, Hiroyuki Gatanaga, Tsunefusa Hayashida, Mayumi Imahashi, Rumi Minami, Michiko Koga, Sei Samukawa, Dai Watanabe, Teruhisa Fujii, Masao Tateyama, Hideta Nakamura, Shuzo Matsushita, Yusuke Yoshino, Tomoyuki Endo, Masahide Horiba, Toshibumi Taniguchi, Hiroshi Moro, Hidetoshi Igari, Shigeru Yoshida, Takanori Teshima, Hideaki Nakajima, Masako Nishizawa, Yoshiyuki Yokomaku, Yasumasa Iwatani, Atsuko Hachiya, Shingo Kato, Naoki Hasegawa, Kazuhisa Yoshimura, Wataru Sugiura, Tadashi Kikuchi

    Journal of Antimicrobial Chemotherapy   2023.10

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    Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    Abstract

    Background

    Integrase strand transfer inhibitors (INSTIs) are recommended as first-line ART for people living with HIV (PLWH) in most guidelines. The INSTI-resistance-associated mutation E157Q, a highly prevalent (2%–5%) polymorphism of the HIV-1 (human immunodeficiency virus type 1) integrase gene, has limited data on optimal first-line ART regimens. We assessed the virological outcomes of various first-line ART regimens in PLWH with E157Q in real-world settings.

    Methods

    A multicentre retrospective observational study was conducted on PLWH who underwent integrase genotypic drug-resistance testing before ART initiation between 2008 and 2019 and were found to have E157Q. Viral suppression (<50 copies/mL) rate at 24 and 48 weeks, time to viral suppression and time to viral rebound (≥100 copies/mL) were compared among the first-line ART regimens.

    Results

    E157Q was detected in 167 (4.1%) of 4043 ART-naïve PLWH. Among them, 144 had available clinical data after ART initiation with a median follow-up of 1888 days. Forty-five started protease inhibitors + 2 NRTIs (PI group), 33 started first-generation INSTI (raltegravir or elvitegravir/cobicistat) + 2 NRTIs (INSTI-1 group), 58 started once-daily second-generation INSTI (dolutegravir or bictegravir) + 2 NRTIs (INSTI-2 group) and eight started other regimens. In the multivariate analysis, the INSTI-2 group showed similar or favourable outcomes compared with the PI group for viral suppression rates, time to viral suppression and time to viral rebound. Two cases in the INSTI-1 group experienced virological failure.

    Conclusions

    The general guideline recommendation of second-generation INSTI-based first-line ART for most PLWH is also applicable to PLWH harbouring E157Q.

    DOI: 10.1093/jac/dkad319

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  • Preparing of Point-of-Care Reagents for Risk Assessment in the Elderly at Home by a Home-Visit Nurse and Verification of Their Analytical Accuracy Reviewed

    Shoji Takenaka, Hiroshi Moro, Utako Shimizu, Takeshi Koizumi, Kei Nagano, Naoki Edanami, Naoto Ohkura, Hisanori Domon, Yutaka Terao, Yuichiro Noiri

    Diagnistics   ahead of online ( 14 )   2407 - 2407   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MDPI AG  

    With the rising number of older adults residing at home, there is a growing need for risk assessment and patient management in home nursing. This study aims to develop point-of-care test (POCT) reagents that can aid in risk assessment and home care, especially in settings with limited resources. Our focus was on creating a C-reactive protein (CRP) POCT, which can accurately diagnose clinically significant judgment values in home nursing. Additionally, we assessed the utility of the HemoCue WBC DIFF system in providing differential counts of white blood cells (WBC). These performances were compared with a laboratory test using blood samples from patients with pneumonia. The CRP POCT showed a comparable result to that of a laboratory method, with an average kappa index of 0.883. The leukocyte count showed good agreement with the reference method. While the correlation coefficients for both neutrophil and lymphocyte counts were deemed acceptable, it was observed that the measured values tended to be smaller in cases where the cell count was higher. This proportional error indicates a weak correlation with the neutrophil-to-lymphocyte ratio. CRP POCT and WBC counts provided reliable and accurate judgments. These tools may benefit risk management for older adults at home, patients with dementia who cannot communicate, and those living in depopulated areas.

    DOI: 10.3390/diagnostics13142407

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  • Association of demographics, HCV co‐infection, HIV‐1 subtypes and genetic clustering with late HIV diagnosis: a retrospective analysis from the Japanese Drug Resistance HIV‐1 Surveillance Network Reviewed

    Machiko Otani, Teiichiro Shiino, Atsuko Hachiya, Hiroyuki Gatanaga, Dai Watanabe, Rumi Minami, Masako Nishizawa, Takanori Teshima, Shigeru Yoshida, Toshihiro Ito, Tsunefusa Hayashida, Michiko Koga, Mami Nagashima, Kenji Sadamasu, Makiko Kondo, Shingo Kato, Shunsuke Uno, Toshibumi Taniguchi, Hidetoshi Igari, Sei Samukawa, Hideaki Nakajima, Yusuke Yoshino, Masahide Horiba, Hiroshi Moro, Tamayo Watanabe, Mayumi Imahashi, Yoshiyuki Yokomaku, Haruyo Mori, Teruhisa Fujii, Kiyonori Takada, Asako Nakamura, Hideta Nakamura, Masao Tateyama, Shuzo Matsushita, Kazuhisa Yoshimura, Wataru Sugiura, Tetsuro Matano, Tadashi Kikuchi

    Journal of the International AIDS Society   26 ( 5 )   2023.5

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/jia2.26086

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  • An outbreak of serotype 19A pneumococcal pneumonia in a relief facility in Japan Reviewed

    Kei Nagano, Satoshi Kawasaki, Hiroshi Moro, Bin Chang, Yuuki Bamba, Ayako Yamamoto, Masatomo Morita, Makoto Ohnishi, Satoshi Shibata, Takeshi Koizumi, Nobumasa Aoki, Yasuo Honma, Tetsuya Abe, Toshiyuki Koya, Nobuki Aoki, Toshiaki Kikuchi

    Infection Control & Hospital Epidemiology   Jul 30   1 - 3   2022.12

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1017/ice.2021.328

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  • Factors associated with cytomegalovirus antigenemia in patients with rheumatic disease: A retrospective study. Reviewed International journal

    Hideyuki Ogata, Nobumasa Aoki, Kei Nagano, Mariko Hakamata, Yuuki Bamba, Satoshi Shibata, Takeshi Koizumi, Yasuyoshi Ohshima, Satoshi Watanabe, Hiroshi Moro, Toshiyuki Koya, Toshiaki Kikuchi

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   28 ( 11 )   1471 - 1477   2022.7

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    INTRODUCTION: This study aimed to examine the factors associated with cytomegalovirus (CMV) antigenemia and the time of onset of CMV antigenemia among patients with rheumatic diseases. METHODS: A single-center, retrospective, observational study was conducted in our institution from January 2009 to December 2017. This study included patients with rheumatic diseases who had at least one CMV antigen measurement. Multivariate analysis and receiver operating characteristic analysis was performed. RESULTS: A total of 249 patients underwent CMV antigenemia assay, and 84 (33.7%) patients tested positive. When the association between CMV antigenemia and possible associated factors was investigated, multivariate analysis showed that daily steroid dose increased the odds of having CMV [odds ratio 16.25, 95% confidence interval (CI), 5.360-49.253]. In this study, the cutoff value of daily steroid dose found in this study (0.45 mg/kg/day) was reasonable in clinical practice, and the area under the curve of the steroid dose was 0.838 [95% CI 0.781-0.882], which was the largest of the known indicators. Moreover, the median time from the start of immunosuppressive therapy to the onset of CMV antigenemia was 30 (interquartile range, 21-44) days, and most of the daily steroid users (85.7%) developed CMV antigenemia within 60 days. CONCLUSIONS: The daily steroid dose is the most important factor associated with CMV antigenemia. Therefore, monitoring and treatment strategies based on the steroid dose, especially in the initial 2 months, are important.

    DOI: 10.1016/j.jiac.2022.07.004

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  • Association between extended-spectrum β-lactamase-producing Escherichia coli and oral third-generation cephalosporins. Reviewed International journal

    Hiroki Hosokawa, Satoru Mitsuboshi, Hirokazu Isobe, Kenichi Kobayashi, Hiroshi Moro, Toshiaki Kikuchi

    Infection control and hospital epidemiology   43 ( 2 )   261 - 263   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Cambridge University Press (CUP)  

    DOI: 10.1017/ice.2020.1400

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  • Efficacy of the new β-D-glucan measurement kit for diagnosing invasive fungal infections, as compared with that of four conventional kits Reviewed International journal

    Yuuki Bamba, Kei Nagano, Hiroshi Moro, Hideyuki Ogata, Mariko Hakamata, Satoshi Shibata, Takeshi Koizumi, Nobumasa Aoki, Yasuyoshi Ohshima, Satoshi Watanabe, Takeshi Nakamura, Sugako Kobayashi, Yoshiki Hoshiyama, Toshiyuki Koya, Toshinori Takada, Toshiaki Kikuchi

    PLOS ONE   16 ( 8 )   e0255172.   2021.8

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Each of the currently available (1→3)-β-D-glucan (BDG) measurement kits follows a different measurement method and cut-off value. Comparisons of diagnostic performance for invasive fungal infections (IFIs) are desirable. Additionally, ecological considerations are becoming increasingly important in the development of new measurement kits. METHODS: The plasma BDG levels in clinical samples were measured using the following currently available kits: the Fungitec G test MKII, the Fungitec G test ES, Fungitell, the β-Glucan test Wako, and the newly developed Wako kit (Wako-Eu). Wako-Eu uses a pre-treatment solution that conforms to European regulations for the registration, evaluation, authorisation, and restriction of chemicals. The values obtained for the samples using each kit were studied and compared. RESULTS: Of the 165 patients evaluated, 12 had IFIs, including pneumocystis pneumonia, aspergillosis, and candidiasis. BDG values obtained using the kits were moderately correlated with each other. Clinical diagnoses of the evaluated cases indicated that 21 false positives were diagnosed by at least one kit. The sensitivity of the Fungitell kit was relatively low, but those of the other four were over 90%. The specificity was above 90% for all kits. For positive predictive value, the Wako and the Wako-Eu methods were superior to the others owing to fewer false positive results. CONCLUSIONS: The newly developed Wako-Eu method, which considers ecological concerns, shows diagnostic performance equivalent to that of its predecessor. To improve the diagnostic accuracy of IFIs, it is necessary to interpret the results carefully, giving due consideration to the characteristics of each measurement kit.

    DOI: 10.1371/journal.pone.0255172

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  • Saliva as a potential matrix for evaluating pharmacologically active dolutegravir concentration in plasma Reviewed

    Eiko Yamada, Ritsuo Takagi, Hiroshi Moro, Koji Sudo, Shingo Kato

    PLOS ONE   16 ( 2 )   e0246994 - e0246994   2021.2

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    Therapeutic drug monitoring (TDM) is used in certain clinically selected cases and in research settings to optimize the response to antiretroviral therapy. Plasma of blood is commonly used for TDM, but blood sampling is invasive and at risk for transmission of infectious agents. On the other hand, saliva sampling is noninvasive, safe, cheap, and easily performed compared to blood. Dolutegravir (DTG) is now widely prescribed as a key component of antiretroviral therapy for HIV infection. In this study, we examined the relationship between DTG concentrations in plasma and saliva of treated patients to explore the possibility of using saliva as an alternative body fluid of TDM. A total of 17 pairs of blood and saliva samples were obtained from 15 consented HIV-1-infected subjects treated with DTG containing regimens for more than one month. Both blood and saliva samples were collected within 1 h of each other. Drug concentrations were determined by liquid chromatography-tandem mass spectrometry using DTG-d5 as an internal standard. The LLOQ was 0.5 ng/mL. The calibration curves were prepared with pooled plasma or saliva containing DTG in a range of 0.5–100 ng/mL with precision of &lt;14.4% and accuracy within ±14.7%. The DTG concentrations in the plasma and saliva were significantly correlated (Pearson’s correlation coefficient <italic>r</italic> = 0.76, <italic>p</italic> &lt; 0.001). The median ratio of the drug concentration in saliva to those in plasma was 0.0056, which is close to the rate of non-protein-bound DTG in plasma (0.70%), suggesting that only free DTG in plasma is transported to the salivary glands and secreted into saliva. The present study demonstrates that DTG concentration in saliva reflects the pharmacologically active drug concentration in plasma and may provide an easily accessible alternative for monitoring effective antiretroviral treatment.

    DOI: 10.1371/journal.pone.0246994

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  • Higher genome mutation rates of Beijing lineage of Mycobacterium tuberculosis during human infection Reviewed International journal

    Mariko Hakamata, Hayato Takihara, Tomotada Iwamoto, Aki Tamaru, Atsushi Hashimoto, Takahiro Tanaka, Shaban A. Kaboso, Gebremichal Gebretsadik, Aleksandr Ilinov, Akira Yokoyama, Yuriko Ozeki, Akihito Nishiyama, Yoshitaka Tateishi, Hiroshi Moro, Toshiaki Kikuchi, Shujiro Okuda, Sohkichi Matsumoto

    Scientific Reports   10 ( 1 )   17997 - 17997   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    <title>Abstract</title>
    <italic>Mycobacterium tuberculosis</italic> (<italic>Mtb</italic>) strains of Beijing lineage have caused great concern because of their rapid emergence of drug resistance and worldwide spread. DNA mutation rates that reflect evolutional adaptation to host responses and the appearance of drug resistance have not been elucidated in human-infected Beijing strains. We tracked and obtained an original <italic>Mtb</italic> isolate of Beijing lineage from the 1999 tuberculosis outbreak in Japan, as well as five other isolates that spread in humans, and two isolates from the patient caused recurrence. Three isolates were from patients who developed TB within one year after infection (rapid-progressor, RP), and the other three isolates were from those who developed TB more than one year after infection (slow-progressor, SP). We sequenced genomes of these isolates and analyzed the propensity and rate of genomic mutations. Generation time versus mutation rate curves were significantly higher for RP. The ratio of oxidative versus non-oxidation damages induced mutations was higher in SP than RP, suggesting that persistent <italic>Mtb</italic> are exposed to oxidative stress in the latent state. Our data thus demonstrates that higher mutation rates of <italic>Mtb</italic> Beijing strains during human infection is likely to account for the higher adaptability and an emergence ratio of drug resistance.

    DOI: 10.1038/s41598-020-75028-2

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    Other Link: http://www.nature.com/articles/s41598-020-75028-2

  • Disseminated Mycobacterium abscessus subsp. massiliense infection in a Good’s syndrome patient negative for human immunodeficiency virus and anti-interferon-γ autoantibody: a case report Reviewed

    Waki Imoto, Koichi Yamada, Yuriko Hajika, Kousuke Okamoto, Yuka Myodo, Makoto Niki, Gaku Kuwabara, Kazushi Yamairi, Wataru Shibata, Naoko Yoshii, Kiyotaka Nakaie, Kazutaka Yoshizawa, Hiroki Namikawa, Tetsuya Watanabe, Kazuhisa Asai, Hiroshi Moro, Yukihiro Kaneko, Tomoya Kawaguchi, Yoshiaki Itoh, Hiroshi Kakeya

    BMC Infectious Diseases   20 ( 1 )   2020.12

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    <title>Abstract</title><sec>
    <title>Background</title>
    Good’s syndrome (GS) is characterized by immunodeficiency, and can lead to severe infection, which is the most significant complication. Although <italic>Mycobacterium</italic> rarely causes infection in patients with GS, disseminated nontuberculous mycobacterial (NTM) infection frequently occurs in GS patients that are also positive for the human immunodeficiency virus (HIV) or anti-interferon (IFN)-γ autoantibodies. Here, we report a rare case of GS with NTM without HIV or IFN-γ autoantibodies.


    </sec><sec>
    <title>Case presentation</title>
    A 57-year-old Japanese male with GS and myasthenia gravis (treated with prednisolone and tacrolimus) was diagnosed with disseminated NTM infection caused by <italic>Mycobacterium abscessus</italic> subsp. <italic>massiliense</italic>. He presented with fever and back pain. Blood, lumbar tissue, urine, stool, and sputum cultures tested positive for <italic>M. abscessus</italic>. Bacteremia, spondylitis, intestinal lumber abscess, and lung infection were confirmed by bacteriological examination and diagnostic imaging; urinary and intestinal tract infections were suspected by bacteriological examination but not confirmed by imaging. Despite multidrug combination therapy, including azithromycin, imipenem/cilastatin, levofloxacin, minocycline, linezolid, and sitafloxacin, the patient ultimately died of the infection. The patient tested negative for HIV and anti-IFN-γ autoantibodies.


    </sec><sec>
    <title>Conclusions</title>
    Since myasthenia gravis symptoms interfere with therapy, patients with GS and their physicians should carefully consider the antibacterial treatment options against disseminated NTM.


    </sec>

    DOI: 10.1186/s12879-020-05136-x

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    Other Link: https://link.springer.com/article/10.1186/s12879-020-05136-x/fulltext.html

  • Multiplex cytokine analysis in Mycobacterium avium complex lung disease: relationship between CXCL10 and poor prognostic factors Reviewed International journal

    Yuuki Bamba, Hiroshi Moro, Nobumasa Aoki, Takeshi Koizumi, Yasuyoshi Ohshima, Satoshi Watanabe, Takuro Sakagami, Toshiyuki Koya, Toshinori Takada, Toshiaki Kikuchi

    BMC Infectious Diseases   19 ( 1 )   263 - 263   2019.12

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    BACKGROUND: Mycobacterium avium complex lung disease (MAC-LD) can deteriorate rapidly to become fatal. Reported poor prognostic factors include radiographic findings, undernutrition, anemia and high inflammation test values. However, the association of these prognostic factors with the pathophysiology of the disease remains unknown. We aimed to clarify the pathophysiology of MAC-LD and develop a new biomarker that reflects the immune response to the disease. METHODS: We performed the cytokine panel analyses of serum from patients with MAC-LD and compared each cytokine level with clinically negative prognostic factors (radiographic disease type, body mass index, albumin, C-reactive protein and hemoglobin) and high-resolution CT scores. RESULTS: We analyzed 27 patients with MAC-LD, 6 with the fibrocavitary form and 21 with the nodular bronchiectatic form on high-resolution CT. Serum CXC motif ligand 10 (CXCL10) concentration was significantly elevated in patients with the fibrocavitary form (p = 0.008). CXCL10 levels correlated with body mass index (r = - 0.60, p = 0.0008), serum albumin concentration (r = - 0.45, p = 0.016) and high-resolution CT scores (r = 0.61, p = 0.0006). Among 14 patients initially untreated, antibiotic therapy was initiated for five during the study period. CXCL10 concentration was significantly higher in these patients (p = 0.046), and receiver operating characteristic analysis for CXCL10 concentration on treatment initiation produced an area under the curve of 0.844, with a sensitivity of 100%, specificity of 66.7%, and cut-off value of 366.5 pg/mL. CONCLUSION: We revealed cytokine profiles in patients with MAC-LD. Serum CXCL10 levels probably reflect the severity of MAC-LD. Our findings suggest that CXCL10 concentration may be a promising biomarker for managing treatment for patients with MAC disease of the lung.

    DOI: 10.1186/s12879-019-3888-4

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    Other Link: http://link.springer.com/article/10.1186/s12879-019-3888-4/fulltext.html

  • Comparison Between Three (1→3)-β-D-glucan Measurement Kits in Japan for the Diagnosis of Invasive Fungal Infection Reviewed

    Yuuki BAMBA, Hiroshi MORO, Kei NAGANO, Mariko HAKAMATA, Sho SHIMAZU, Hideyuki OGATA, Takeshi KOIZUMI, Hitomi CHO, Nobumasa AOKI, Masachika HAYASHI, Mizuho SATO, Akiko SAKAGAMI, Toshiyuki KOYA, Toshiaki KIKUCHI

    Kansenshogaku Zasshi   93 ( 4 )   500 - 506   2019.8

  • Increased presepsin levels are associated with the severity of fungal bloodstream infections Reviewed International journal

    Yuuki Bamba, Hiroshi Moro, Nobumasa Aoki, Takeshi Koizumi, Yasuyoshi Ohshima, Satoshi Watanabe, Takuro Sakagami, Toshiyuki Koya, Toshinori Takada, Toshiaki Kikuchi

    PLOS ONE   13 ( 10 )   e0206089 - e0206089   2018.10

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Public Library of Science (PLoS)  

    BACKGROUND: Presepsin is a widely recognized biomarker for sepsis. However, little is known about the usefulness of presepsin in invasive fungal infection. The aim of this study was to determine the plasma levels of presepsin in fungal bloodstream infections and to investigate whether it reflects the disease severity, similar to its utility in bacterial infections. METHODS: We prospectively measured presepsin in plasma samples from participants with fungemia from April 2016 to December 2017. The associations of C-reactive protein, procalcitonin, and presepsin concentrations with the severity of fungemia were statistically analyzed. In vitro assay was performed by incubating Escherichia coli, Candida albicans, and lipopolysaccharide to whole blood cells collected from healthy subjects; after 3 h, the presepsin concentration was measured in the supernatant and was compared among the bacteria, fungi, and LPS groups. RESULTS: Presepsin was increased in 11 patients with fungal bloodstream infections. Serial measurement of presepsin levels demonstrated a prompt decrease in 7 patients in whom treatment was effective, but no decrease or further increase in the patients with poor improvement. Additionally, presepsin concentrations were significantly correlated with the Sequential Organ Failure Assessment score (r = 0.89, p < 0.001). In vitro assay with co-incubation of C. albicans and human whole blood cells indicated that the viable cells of C. albicans caused an increase in presepsin, as seen with E. coli. CONCLUSIONS: Plasma presepsin levels increased in patients with fungal bloodstream infection, with positive association with the disease severity. Presepsin could be a useful biomarker of sepsis secondary to fungal infections.

    DOI: 10.1371/journal.pone.0206089

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  • Clinical Significance of Interferon-γ Neutralizing Autoantibodies Against Disseminated Nontuberculous Mycobacterial Disease Reviewed

    Ami Aoki, Takuro Sakagami, Kazutaka Yoshizawa, Kenjiro Shima, Mio Toyama, Yoshinari Tanabe, Hiroshi Moro, Nobumasa Aoki, Satoshi Watanabe, Toshiyuki Koya, Takashi Hasegawa, Kozo Morimoto, Atsuyuki Kurashima, Yoshihiko Hoshino, Bruce C Trapnell, Toshiaki Kikuchi

    Clinical Infectious Diseases   66 ( 8 )   1239 - 1245   2018.4

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  • A-DROP system for prognostication of NHCAP inpatients Reviewed International journal

    Takeshi Koizumi, Hiroki Tsukada, Kazuhiko Ito, Satoshi Shibata, Satoshi Hokari, Takafumi Tetsuka, Nobumasa Aoki, Hiroshi Moro, Yoshinari Tanabe, Toshiaki Kikuchi

    Journal of Infection and Chemotherapy   23 ( 8 )   523 - 530   2017.8

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    Nursing and healthcare-associated pneumonia (NHCAP) is a category of healthcare-associated pneumonia that was modified for the healthcare system of Japan. The NHCAP guidelines stated the difficulty in assessing the severity classifications, for instance, A-DROP. We compared the usefulness of different severity classifications (A-DROP, CURB-65, PSI, and I-ROAD) in predicting the prognosis of nursing and healthcare-associated pneumonia. We conducted a retrospective analysis on 303 adult patients hospitalized for nursing healthcare-associated pneumonia and community-acquired pneumonia, which were diagnosed at the Department of Respiratory Medicine of Niigata General City Hospital between January 2012 and December 2014. We evaluated 159 patients with community-acquired pneumonia and 144 with nursing and healthcare-associated pneumonia. In the nursing and healthcare-associated pneumonia group, 30-days mortality and in-hospital mortality rates were 6.5% and 8.7%, respectively, in severe cases and 16.1% and 25.0%, respectively, in the most severe cases, based on A-DROP. With I-ROAD, these rates were 11.1% and 11.1%, respectively, in group B and 14.9% and 20.7%, respectively, in group C. With PSI, the rates were 2.3% and 6.8%, respectively, in class IV and 14.3% and 19.8%, respectively, in class V. Despite some variability due to the small sample size, both the 30-days and in-hospital mortality rates increased as the severity increased. In this study, both the 30-days mortality and in-hospital mortality rates in the nursing and healthcare-associated pneumonia group tended to increase in severity with the A-DROP. We found that A-DROP was useful in predicting the prognosis of nursing and healthcare-associated pneumonia.

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  • Elevated serum interferon Î 3-induced protein 10 kDa is associated with TAFRO syndrome Reviewed

    Noriko Iwaki, Yuka Gion, Eisei Kondo, Mitsuhiro Kawano, Taro Masunari, Hiroshi Moro, Koji Nikkuni, Kazue Takai, Masao Hagihara, Yuko Hashimoto, Kenji Yokota, Masataka Okamoto, Shinji Nakao, Tadashi Yoshino, Yasuharu Sato

    Scientific Reports   7   2017.2

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    Multicentric Castleman disease (MCD) is a heterogeneous lymphoproliferative disorder. It is characterized by inflammatory symptoms, and interleukin (IL)-6 contributes to the disease pathogenesis. Human herpesvirus 8 (HHV-8) often drives hypercytokinemia in MCD, although the etiology of HHV-8-negative MCD is idiopathic (iMCD). A distinct subtype of iMCD that shares a constellation of clinical features including thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O) has been reported as TAFRO-iMCD, however the differences in cytokine profiles between TAFRO-iMCD and iMCD have not been established. We retrospectively compared levels of serum interferon Î 3-induced protein 10 kDa (IP-10), platelet-derived growth factor (PDGF)-AA, interleukin (IL)-10, and other cytokines between 11 cases of TAFRO-iMCD, 6 cases of plasma cell type iMCD, and 21 healthy controls. During flare-ups, patients with TAFRO-iMCD had significantly higher serum IP-10 and tended to have lower PDGF-AA levels than the other 2 groups. In addition, serum IL-10, IL-23, and vascular endothelial growth factor-A were elevated in both TAFRO-iMCD and iMCD. Elevated serum IP-10 is associated with inflammatory diseases including infectious diseases. There was a strong correlation between high serum IP-10 and the presence of TAFRO-iMCD, suggesting that IP-10 might be involved in the pathogenesis of TAFRO-iMCD.

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  • [The Effect of Intravenous Gamma-globulin Reagents on the Measurement Results of (1➔3)-β-D-glucan]. Reviewed

    Hiroshi Moro, Nao Koshio, Yuuki Bamba, Takeshi Koizumi, Hiromi Cho, Nobumasa Aoki, Masachika Hayashi, Chikako Tsubata, Akiko Sakagami, Mizuho Sato, Takuro Sakagami, Toshiyuki Koya, Yoshinari Tanabe, Toshiaki Kikuchi

    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases   91 ( 1 )   1 - 6   2017.1

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    Serum (1→3) beta-D-glucan (BG) measurement is a useful test for systemic mycoses, and often used. On the other hand, various factors, including administration of intravenous immunoglobulins (IVIG) may cause false-positives. In the present study, we measured BG concentration of seven IVIG preparations with three lots respectively. BG levels varied with individual IVIG preparations (<3.0 - >300 pg/mL), and contamination from manufacturing processes was suspected.

    With serum BG concentration of clinical specimens obtained in Niigata University Medical & Dental Hospital, the difference between before and after administration of IVIG were calculated.

    The false-positive rate of BG due to IVIG administration was 9.8 %, and the positive predective value was reduced to 37.5%. Above all, administration of IVIG can complicate the BG test's interpretation, and caution is required.

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  • Transfer of in vitro-expanded naïve T cells after lymphodepletion enhances antitumor immunity through the induction of polyclonal antitumor effector T cells Reviewed

    Tanaka, T., Watanabe, S., Takahashi, M., Sato, K., Saida, Y., Baba, J., Arita, M., Sato, M., Ohtsubo, A., Shoji, S., Nozaki, K., Ichikawa, K., Kondo, R., Aoki, N., Ohshima, Y., Sakagami, T., Abe, T., Moro, H., Koya, T., Tanaka, J., Kagamu, H., Yoshizawa, H., Kikuchi, T.

    PLoS ONE   12 ( 8 )   2017

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  • Pneumonia Severity Assessment Tools for Predicting Mortality in Patients with Healthcare-Associated Pneumonia: A Systematic Review and Meta-Analysis Reviewed

    Noguchi, S., Yatera, K., Kawanami, T., Fujino, Y., Moro, H., Aoki, N., Komiya, K., Kadota, J.-I., Shime, N., Tsukada, H., Kohno, S., Mukae, H.

    Respiration   93 ( 6 )   441 - 450   2017

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  • 医療従事者のHIV感染者受け入れへの不安 HIV出張研修アンケートからの検討 Reviewed

    中川 雄真, 茂呂 寛, 川口 玲, 内山 正子, 新保 明日香, 三枝 祐美, 野田 順子, 鈴木 啓記, 柴田 怜, 張 仁美, 佐藤 瑞穂, 菊地 利明

    日本エイズ学会誌   23 ( 3 )   113 - 121   2021.8

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    2012〜2018年に新潟県内のエイズ治療拠点病院以外の病院を対象にHIV/エイズ出張研修会を行い、研修会前後のアンケート結果を分析した。事前アンケート回答者6791名、事後アンケート回答者4529名で、職種は事前・事後とも看護師が最も多く、次いで事務職・クラークであった。回答は、研修会は実践に非常に役立った4452名(98.3%)、HIV患者や診療に対する気持ちや考え方に変化があった3365名(74.3%)、利用者の受入れ可能3827名(84.5%)で、HIV感染者受入れ促進の取組みとしての研修会の有効性が示唆された。しかし、HIV感染者と関わることへの不安は研修会前後で変化がなく、感染への不安がHIV診療の受入れを妨げていることが示唆された。

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  • 当院におけるVentilator-Associated Events(VAE)サーベイランスと旧定義Ventilator-Associated Pneumonia(VAP)サーベイランスとの比較検討 Reviewed

    佐藤瑞穂, 内山正子, 青木美栄子, 坂上亜希子, 津畑千佳子, 茂呂寛, 田邊嘉也, 菊地利明

    日本環境感染学会誌   34 ( 3 )   162 - 168   2019

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  • サルコイドーシス/サルコイド反応合併肺癌の病期決定におけるEBUS-TBNAの有用性

    肺癌   58 ( 2 )   88 - 92   2018.4

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    目的. サルコイドーシスやサルコイド反応は肺門・縦隔リンパ節腫大を呈し、これらを合併した肺癌症例には、リンパ節病変の評価が治療方針決定上で問題となる。本研究では、これらサルコイド反応合併肺癌症例の病期診断におけるEBUS-TBNAの有用性を検討した。対象と方法. 2009年1月から2016年12月に気管支鏡検査を実施され、サルコイドーシス/サルコイド反応と肺癌の合併と診断された症例におけるEBUS-TBNAの有効性について検討した。結果. EBUS-TBNAにより、サルコイドーシス/サルコイド反応と肺癌との合併と診断された症例は4例であった。造影CT、FDG-PET/CTでは癌のリンパ節転移とサルコイドーシス/サルコイド反応の鑑別は困難であった。4例中3例はI期の非小細胞肺癌と診断され、2例は手術が施行された。術後検体でも転移はなく、granulomaが認められたことから、サルコイド反応と診断された。4例中1例は全身性サルコイドーシスに合併したIII期の肺癌症例であった。結論. サルコイドーシス/サルコイド反応合併肺癌症例におけるN因子の評価に、EBUS-TBNAは有用であると考えられる。(著者抄録)

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J01244&link_issn=&doc_id=20180515270004&doc_link_id=%2Fec7jaluc%2F2018%2F005802%2F004%2F0088-0092%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fec7jaluc%2F2018%2F005802%2F004%2F0088-0092%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • HIV感染症患者のメンタルヘルスとそのスクリーニングに関する考察 GHQ30の継続的評価と孤独感やソーシャルサポートとの量的分析から Reviewed

    早津正博, 古谷野淳子, 川口玲, 石塚さゆり, 青木信将, 茂呂寛, 田邊嘉也

    日本エイズ学会誌   20 ( 1 )   53 - 69   2018

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    継続的に受診していたHIV感染症患者(2009年29人、2011年31人、2013年41人、2014年38人)を臨床群、HIVおよび慢性疾患に罹患していない92人を対照群とした。[情緒的ソーシャルサポート]、[現実的ソーシャルサポート]、[対他的孤独感]、[実存的孤独感]、[孤独不安耐性]の信頼性係数は十分な値であった。ウェルチの検定で、[希死念慮うつ傾向]と[情緒的ソーシャルサポート]、[対他的孤独感]において有意差を認めた。ウェルチの検定の結果も踏まえれば、臨床群は対照群との平均値の比較において、[希死念慮うつ傾向]は高く、[情緒的ソーシャルサポート]は低く、[他的孤独感]は高いことが有意にいえるがその差はわずかであった。GHQ30の陽性判定の繰り返しに注目し、その説明因子やリスクについて検討し、希死念慮や抑うつ気分を持つかどうかが、メンタルヘルス不調の反復性を説明する上で重要であることが示された。メンタルヘルスのリスク因子と考えられる[希死念慮うつ傾向]に対しては、[対他的孤独感]が促進的影響、[孤独不安耐性]が抑制的影響を与えることが示された。

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  • Prognostic implications of aspiration pneumonia in patients with community acquired pneumonia: A systematic review with meta-analysis Reviewed International journal

    Kosaku Komiya, Bruce K. Rubin, Jun-ichi Kadota, Hiroshi Mukae, Tomohiro Akaba, Hiroshi Moro, Nobumasa Aoki, Hiroki Tsukada, Shingo Noguchi, Nobuaki Shime, Osamu Takahashi, Shigeru Kohno

    Scientific Reports   6 ( 1 )   38097 - 38097   2016.12

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    Aspiration pneumonia is thought to be associated with a poor outcome in patients with community acquired pneumonia (CAP). However, there has been no systematic review regarding the impact of aspiration pneumonia on the outcomes in patients with CAP. This review was conducted using the MOOSE guidelines: Patients: patients defined CAP. EXPOSURE: aspiration pneumonia defined as pneumonia in patients who have aspiration risk. Comparison: confirmed pneumonia in patients who were not considered to be at high risk for oral aspiration. OUTCOMES: mortality, hospital readmission or recurrent pneumonia. Three investigators independently identified published cohort studies from PubMed, CENTRAL database, and EMBASE. Nineteen studies were included for this systematic review. Aspiration pneumonia increased in-hospital mortality (relative risk, 3.62; 95% CI, 2.65-4.96; P < 0.001, seven studies) and 30-day mortality (3.57; 2.18-5.86; P < 0.001, five studies). In contrast, aspiration pneumonia was associated with decreased ICU mortality (relative risk, 0.40; 95% CI, 0.26-0.60; P < 0.00001, four studies). Although there are insufficient data to perform a meta-analysis on long-term mortality, recurrent pneumonia, and hospital readmission, the few reported studies suggest that aspiration pneumonia is also associated with these poor outcomes. In conclusion, aspiration pneumonia was associated with both higher in-hospital and 30-day mortality in patients with CAP outside ICU settings.

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  • Clinicopathologic analysis of TAFRO syndrome demonstrates a distinct subtype of HHV-8-negative multicentric Castleman disease Reviewed

    Noriko Iwaki, David C. Fajgenbaum, Christopher S. Nabel, Yuka Gion, Eisei Kondo, Mitsuhiro Kawano, Taro Masunari, Isao Yoshida, Hiroshi Moro, Koji Nikkuni, Kazue Takai, Kosei Matsue, Mitsutoshi Kurosawa, Masao Hagihara, Akio Saito, Masataka Okamoto, Kenji Yokota, Shinichiro Hiraiwa, Naoya Nakamura, Shinji Nakao, Tadashi Yoshino, Yasuharu Sato

    American Journal of Hematology   91 ( 2 )   220 - 226   2016.2

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    Multicentric Castleman disease (MCD) describes a heterogeneous group of disorders involving systemic inflammation, characteristic lymph node histopathology, and multi-organ dysfunction because of pathologic hypercytokinemia. Whereas Human Herpes Virus-8 (HHV-8) drives the hypercytokinemia in a cohort of immunocompromised patients, the etiology of HHV-8-negative MCD is idiopathic (iMCD). Recently, a limited series of iMCD cases in Japan sharing a constellation of clinical features, including thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O) has been described as TAFRO syndrome. Herein, we report clinicopathological findings on 25 patients (14 males and 11 females
    23 Japanese-born and two US-born), the largest TAFRO syndrome case series, including the first report of cases from the USA. The median age of onset was 50 years old (range: 23-72). The frequency of each feature was as follows: thrombocytopenia (21/25), anasarca (24/25), fever (21/25), organomegaly (25/25), and reticulin fibrosis (13/16). These patients frequently demonstrated abdominal pain, elevated serum alkaline phosphatase levels, and acute kidney failure. Surprisingly, none of the cases demonstrated marked hypergammoglobulinemia, which is frequently reported in iMCD. Lymph node biopsies revealed atrophic germinal centers with enlarged nuclei of endothelial cells and proliferation of endothelial venules in interfollicular zone. 23 of 25 cases were treated initially with corticosteroids
    12 patients responded poorly and required further therapy. Three patients died during the observation period (median: 9 months) because of disease progression or infections. TAFRO syndrome is a unique subtype of iMCD that demonstrates characteristic clinicopathological findings. Further study to clarify prognosis, pathophysiology, and appropriate treatment is needed.

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  • A case of severe thrombocytopaenia associated with acute HIV-1 infection Reviewed

    Ami Aoki, Hiroshi Moro, Takayuki Watanabe, Katsuaki Asakawa, Satoru Miura, Masato Moriyama, Yoshinari Tanabe, Hiroshi Kagamu, Ichiei Narita

    INTERNATIONAL JOURNAL OF STD & AIDS   26 ( 3 )   209 - 211   2015.3

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    A 23-year-old man was admitted to our hospital with severe thrombocytopaenia. He had unprotected sexual contact 6 weeks earlier. He was diagnosed with acute HIV infection by means of HIV RNA viral load testing and HIV-associated thrombocytopaenia. Although his thrombocytopaenia improved immediately with short-term dexamethasone therapy, this effect was not sustained after cessation of therapy. Antiretroviral therapy including raltegravir was initiated, and the patient recovered from severe thrombocytopaenia within several days. The findings from this case suggest that acute HIV infection should be suspected with unexplained thrombocytopaenia, and that antiretroviral therapy is the treatment of choice for severe HIV-associated thrombocytopaenia, even when in the early period following acquisition of the virus.

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  • Advanced Thymic Cancer Treated with Carboplatin and Paclitaxel in a Patient Undergoing Hemodialysis Reviewed

    Satoru Miura, Hiroshi Kagamu, Takehito Sakai, Koichiro Nozaki, Katsuaki Asakawa, Hiroshi Moro, Masaaki Okajima, Satoshi Watanabe, Suguru Yamamoto, Noriaki Iino, Shin Goto, Junichiro James Kazama, Hirohisa Yoshizawa, Ichiei Narita

    INTERNAL MEDICINE   54 ( 1 )   55 - 58   2015

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    A 53-year-old man with an asymptomatic anterior mediastinal tumor undergoing hemodialysis was referred to our institution. He was diagnosed with thymic basaloid carcinoma based on the findings of a chest tomography-guided biopsy and successfully treated with carboplatin (300 mg/m(2)/day) and paclitaxel (200 mg/ m2/day) on day 1 for six three-week cycles. To our knowledge, this is the first report regarding the efficiency of a carboplatin dose-definition method based on the body surface area with paclitaxel in a hemodialysis patient. This report may therefore be useful for treating hemodialysis patients who are candidates for carboplatin and paclitaxel therapy.

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  • Novel assay to detect increased level of neutralizing anti-interferon gamma autoantibodies in non-tuberculous mycobacterial patients Reviewed

    Kenjiro Shima, Takuro Sakagami, Yoshinari Tanabe, Nobumasa Aoki, Hiroshi Moro, Toshiyuki Koya, Hiroshi Kagamu, Takashi Hasegawa, Ei-ichi Suzuki, Ichiei Narita

    Journal of Infection and Chemotherapy   20 ( 1 )   52 - 56   2014.1

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  • T Cell-Intrinsic and -Extrinsic Contributions of the IFNAR/STAT1-Axis to Thymocyte Survival Reviewed

    Hiroshi Moro, Dennis C. Otero, Yoshinari Tanabe, Michael David

    PLOS ONE   6 ( 9 )   e24972   2011.9

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    STAT1 is an essential part of interferon signaling, and STAT1-deficiency results in heightened susceptibility to infections or autoimmunity in both mice and humans. Here we report that mice lacking the IFN alpha/beta-receptor (IFNAR1) or STAT1 display impaired deletion of autoreactive CD4(+)CD8(+)-T-cells. Strikingly, co-existence of WT T cells restored thymic elimination of self-reactive STAT1-deficient CD4(+)CD8(+)-T cells. Analysis of STAT1-deficient thymocytes further revealed reduced Bim expression, which was restored in the presence of WT T cells. These results indicate that type I interferons and STAT1 play an important role in the survival of MHC class I-restricted T cells in a T cell intrinsic and non-cell intrinsic manner that involves regulation of Bim expression through feedback provided by mature STAT1-competent T cells.

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  • [Results of antifungal susceptibility testing of Candida species and trends of antifungal use in Niigata university medical and dental hospital]. Reviewed

    Aoki, T., Moro, H., Koshio, N., Tamura, T., Tanabe, Y., Kawai, H., Matsuto, T., Okada, M.

    Rinsho byori. The Japanese journal of clinical pathology   58 ( 7 )   658 - 663   2010

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  • HELLP syndrome, multiple liver infarctions, and intrauterine fetal death in a patient with systemic lupus erythematosus and antiphospholipid syndrome

    Wada, Y., Sakamaki, Y., Kobayashi, D., Ajiro, J., Moro, H., Murakami, S., Ooki, I., Kikuchi, A., Takakuwa, K., Tanaka, K., Sato, T., Nakano, M., Narita, I.

    Internal Medicine   48 ( 17 )   2009

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    DOI: 10.2169/internalmedicine.48.2284

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  • Rhabdomyolysis after simvastatin therapy in an HIV-infected patient with chronic renal failure Reviewed

    H Moro, H Tsukada, A Tanuma, A Shirasaki, N Iino, T Nishibori, S Nishi, F Gejyo

    AIDS PATIENT CARE AND STDS   18 ( 12 )   687 - 690   2004.12

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    We encountered a 49-year-old HIV-infected man with chronic renal insufficiency who developed rhabdomyolysis after treatment with simvastatin. He recovered after initiating hemodialysis and discontinuing oral medications. Rhabdomyolysis most likely resulted from an excessive blood concentration of simvastatin caused by concomitant use of fluconazole in the presence of renal insufficiency.

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  • Clinical evaluation of performance of a new diagnostic method for deep mycosis by measuring beta-glucan concentration in the blood Reviewed

    Hiroshi Moro, Hiroki Tsukada, Tatsuki Ohara, Ritsuko Susa, Yoshinari Tanabe, Eiichi Suzuki, Fumitake Gejyo

    Kansenshogaku Zasshi   77 ( 4 )   219 - 226   2003.4

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    β-Glucan Test MARUHA for high sensitive diagnosis of deep mycosis which was developed recently detects (1→3)-β-D-glucan, a component of the cell wall. The performance of β-Glucan Test MARUHA is evaluated in this report.<BR>Although existing methods to detect (1→3)-β-D-glucan have trouble with sulfa drugs, hemolysis, and immunoglobulin G (IgG), these problems were overcome by the β-Glucan Test MARUHA: No effect was observed for β-Glucan Test MARUHA at lower than 200μg/ml, 500mg/dl, and 6, 000mg/dl of sulfa drugs, hemoglobin, and IgG, respectively.<BR>The effect of drugs administrated on the measurement value of β-glucan Test MARUHA was checked at several concentrations. However, almost no effect of drugs, such as, 5 kinds of antifungals, 8 kinds of antibiotics, a kind of antibacterial, 2 kinds of infusions, and a kind of contrast media was observed at the practical concentrations.

    DOI: 10.11150/kansenshogakuzasshi1970.77.219

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  • Comparison of four diagnostic methods using clinical blood by measuring (1-->3)-beta-D-glucan Reviewed

    Hiroshi Moro, Hiroki Tsukada, Tatsuki Ohara, Ritsuko Susa, Yoshinari Tanabe, Eiichi Suzuki, Fumitake Gejyo

    Kansenshogaku Zasshi   77 ( 4 )   227 - 234   2003.4

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    Using Amebocyte lysate of horseshoe crab to measure (1→3)-β-D-glucan specifically, acomponent of the cell wall, several kinds of diagnostic methods for deep mycosis are in practical use in Japan. However, the most important problem is that the judgment of positive or negative is method dependent.<BR>To elucidate the cause of the problem, each measurement value of the identical sample by four methods, β-Glucan Test Maruha (MARUHA), β-Glucan Test Wako (WAKO), FUNGITEC G Test (FUNGITEC-G) and FUNGITEC G Test MK (FUNGITEC-MK) was compared with the clinical data using 119 cases and 289 tests.<BR>Each case was divided into three groups; proven fungal infection, probable fungal infection and non-fungal infection. The negative cases for all the methods tested in the groups of proven fungal infection and probable fungal infection were allergic bronchopulmonary aspergillosis and cryptococcosis, and that for all the methods tested except FUNGITEC-MK method in the group was pulmonary aspergilloma. It seems that these cases cannot be detected correctly by only measuring (1→3)-β-Dglucan.<BR>On the other hand, the ratio of false positive, positive for non-fungal infection group was high in the case of FUNGITEC-MK. About 23% against the total case was positive for FUNGITEC-MK method, but negative for MARUHA, WAKO, and FUNGITEC-G methods. Although the difference of the sensitivity among four methods was not observed, the specificity, the diagnostic efficiency, and the positive predictive value of FUNGITEC-MK method were remarkably lower than those of the other methods due to false positive measurement.<BR>In conclusion, MARUHA, WAKO and FUNGITEC-G except FUNGITEC-MK is not method dependent. It is suggested that FUNGITEC-MK detects non-specific reaction resulted in false positive.

    DOI: 10.11150/kansenshogakuzasshi1970.77.227

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  • A case of Churg-Strauss syndrome with heart failure developed by use of fluticasone propionate

    Koya, T., Takemoto, A., Hosaka, K., Moro, H., Hasegawa, T., Suzuki, E., Gejyo, F.

    Japanese Journal of Allergology   51 ( 11 )   2002

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  • Interleukin-2-dependent but not independent T-cell lines infected with human T-cell leukemia virus type 1 selectively express CD45RO, a marker for persistent infection in vivo Reviewed

    Moro, H., Iwai, K., Mori, N., Watanabe, M., Fukushi, M., Oie, M., Arai, M., Tanaka, Y., Miyawaki, T., Gejyo, F., Arakawa, M., Fujii, M.

    Virus Genes   23 ( 3 )   263 - 271   2001

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    DOI: 10.1023/A:1012565105098

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  • 医の手帳 発熱のメカニズム Invited

    茂呂寛

    朝日新聞 新潟版   2024.1

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  • Clinical Aspects of Pulmonary Nontuberculous Mycobacteriosis

    Hiroshi Moro, Toshiaki Kikuchi

    Internal Medicine   Apr 12. ( 1 )   23 - 27   2021.4

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    Nontuberculous mycobacterial (NTM) infections are an emerging problem. Common organisms include Mycobacterium avium, M. intracellulare, and M. kansasii, along with the M. avium intracellulare complex (MAC), which includes both M. avium and M. intracellulare. Typically, NTM infections affect the lungs and subsequently demonstrate a chronic course. Therefore, persistent respiratory symptoms generally indicate of the presence of pulmonary NTM diseases, and chest radiography, along with a sputum examination, are essential for its diagnosis. Because NTM are ubiquitous environmental organisms, a positive culture from a minimum of two separate expectorated sputum samples are required to make a diagnosis. The repertoire of effective drugs for treatment is considerably limited, indicating the need for long-term management with multiple drugs. Establishing a treatment regimen with high therapeutic efficacy and safety is an important issue for the future.

    DOI: 10.2169/internalmedicine.4361-19

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  • 今月の特集1 やっぱり大事なCRP 感染症におけるCRP

    茂呂 寛

    臨床検査   64 ( 9 )   946 - 951   2020.9

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    DOI: 10.11477/mf.1542202453

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    Other Link: https://search.jamas.or.jp/link/ui/2020376547

  • 感染症で、CRPとWBCが上がるのはなぜ?—特集 知っているとアセスメント・報告が変わる! 異常な検査値の読み方

    茂呂 寛

    Expert nurse = エキスパートナース   36 ( 2 )   20 - 25   2020.2

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    Other Link: https://search.jamas.or.jp/link/ui/2020137104

  • 肺MAC症の臨床経過と対応

    茂呂 寛, 菊地 利明

    日本医事新報   ( 4975 )   18 - 22   2019.8

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    Other Link: https://search.jamas.or.jp/link/ui/2019316603

  • 感染症における鉄代謝~宿主,病原体,抗微生物薬の視点から~ Reviewed

    茂呂 寛

    日本化学療法学会雑誌   67   169 - 175   2019

  • 【抗酸菌感染症の最新情報と展望】 非結核性抗酸菌症の菌側の要因

    菊地 利明, 茂呂 寛

    日本医師会雑誌   147 ( 1 )   53 - 56   2018.4

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  • 【結核・非結核性抗酸菌感染症の今-併発・合併症としての対策を踏まえて】 併発・合併症としての非結核性抗酸菌症の実際 病態・治療・予防まで 関節リウマチと非結核性抗酸菌症 生物学的製剤投与時を中心に

    茂呂 寛, 菊地 利明

    感染と抗菌薬   20 ( 1 )   65 - 70   2017.3

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    生物学的製剤は関節リウマチ(RA)に対して高い治療効果を発揮する一方、非結核性抗酸菌(NTM)症の合併に注意が必要である。事前のスクリーニングが不可欠であるが、診断の確定にあたり、典型的な画像所見に加え、細菌学的検査による厳密な判定を要する。NTM症の存在が明らかな場合、確実な治癒を見込める抗菌薬治療が存在しないため、生物学的製剤は原則として禁忌とされるが、RAの病勢コントロールに対する需要の高まりと、使用経験の蓄積を背景に、一定の条件を満たす場合においてのみ、生物学的製剤の使用が許容されるようになってきた。(著者抄録)

    DOI: 10.34426/j03177.2017146997

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  • 【呼吸器疾患におけるバイオマーカー(BM)】 呼吸器感染症とBM

    番場 祐基, 茂呂 寛, 菊地 利明

    呼吸器内科   30 ( 5 )   401 - 403   2016.11

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  • 【関節リウマチ治療における生物学的製剤を使いこなすためには】 結核症/非結核性抗酸菌症の対策と予防

    茂呂 寛, 菊地 利明

    リウマチ科   56 ( 1 )   58 - 63   2016.7

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  • がん薬物療法を受けた非結核性抗酸菌症併存悪性腫瘍の検討

    田中 知宏, 番場 祐基, 柴田 玲, 大坪 亜矢, 尾形 英至, 庄子 聡, 野嵜 幸一郎, 才田 優, 近藤 利恵, 穂苅 諭, 木村 陽介, 大嶋 康義, 茂呂 寛, 渡部 聡, 小屋 俊之, 菊地 利明

    日本呼吸器学会誌   12 ( 増刊 )   228 - 228   2023.3

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  • 新型コロナウイルス感染症の概要とその対応について—特集 未知の事象への対策

    茂呂 寛

    安全安心社会研究   ( 9 )   1 - 7   2021.9

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  • 【結核を考える-肺結核を中心に】結核の分子疫学検査

    袴田 真理子, 茂呂 寛, 松本 壮吉, 菊地 利明

    呼吸器内科   37 ( 5 )   465 - 470   2020.5

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  • 市中病院の医療介護関連肺炎入院症例のADLと死亡率の検討

    小泉健, 小泉健, 島津翔, 幸田敦, 袴田真理子, 永野啓, 尾方英至, 柴田怜, 張仁美, 佐藤瑞穂, 青木信将, 茂呂寛, 菊地利明, 近幸吉, 原勝人, 堀好寿, 田邊嘉也

    感染症学雑誌   94   2020

  • Iron Metabolism in Infectious Diseases

    NIIGATA MEDICAL JOURNAL   133 ( 3 )   97 - 102   2019.3

  • Treatment and prevention of pneumonia in older adults

    Moro, H., Tsukada, H.

    Japanese Journal of Chemotherapy   67 ( 1 )   2019

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  • Iron metabolism in infectious diseases-Competition of iron acquisition between the host and bacterial pathogens

    Moro, H.

    Japanese Journal of Chemotherapy   67 ( 2 )   2019

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  • 肺MAC症の経過における鉄代謝の動態について

    茂呂寛, 番場祐基, 小泉健, 大嶋康義, 菊地利明

    結核   94 ( 3 )   2019

  • 誤嚥性肺炎の禁食期間と予後の検討

    小泉健, 小泉健, 近幸吉, 原勝人, 島津翔, 尾方英至, 永野啓, 里方真理子, 番場祐基, 張仁美, 青木信将, 佐藤瑞穂, 坂上亜希子, 茂呂寛, 菊地利明, 長谷川隆志, 鈴木榮一, 田邊嘉也, 塚田弘樹

    感染症学雑誌   93   2019

  • 血流感染症における鉄制御因子Lipocalin2の動態について

    茂呂寛, 茂呂寛, 番場祐基, 永野啓, 小泉健, 青木信将, 菊地利明

    感染症学雑誌   93   2019

  • 呼吸器感染症における黄色ブドウ球菌の毒素発現について

    永野啓, 青木信将, 袴田真理子, 尾方英至, 柴田怜, 小泉健, 張仁美, 佐藤瑞穂, 茂呂寛, 菊地利明

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集   68th-66th   2019

  • HIV感染症患者の睡眠障害 多角的視点からの検討

    中川 雄真, 茂呂 寛, 村松 芳幸, 川口 玲, 石田 順子, 野田 順子, 菊地 利明

    日本エイズ学会誌   20 ( 4 )   520 - 520   2018.11

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  • 真菌血流感染症における敗血症バイオマーカーPresepsinの挙動とその有用性

    番場 祐基, 茂呂 寛, 里方 真理子, 尾方 英至, 小泉 健, 青木 信将, 林 正周, 坂上 拓郎, 小屋 俊之, 菊地 利明

    感染症学雑誌   92 ( 3 )   475 - 475   2018.5

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  • CRP上昇を伴わない黄色ブドウ球菌感染症を繰り返し抗IL-6自己抗体の存在が疑われた1例

    吉澤 和孝, 坂上 拓郎, 番場 祐基, 青木 亜美, 林 正周, 青木 信将, 茂呂 寛, 田邊 嘉也, 長谷川 隆志, 小屋 俊之, 菊地 利明

    感染症学雑誌   92 ( 3 )   481 - 481   2018.5

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  • 深在性真菌症における各β-D-グルカン測定試薬の比較

    番場 祐基, 茂呂 寛, 里方 真理子, 尾方 英至, 小泉 健, 青木 信将, 林 正周, 坂上 拓郎, 小屋 俊之, 菊地 利明

    日本化学療法学会雑誌   66 ( Suppl.A )   342 - 342   2018.4

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  • QuantiFERON(QFT)は抗IFN-γ自己抗体のスクリーニングツールになり得る

    吉澤 和孝, 坂上 拓郎, 青木 亜美, 青木 信将, 茂呂 寛, 小屋 俊之, 菊地 利明

    日本呼吸器学会誌   7 ( 増刊 )   186 - 186   2018.3

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  • QuantiFERON(QFT)は抗IFN-γ自己抗体のスクリーニングツールになり得る

    吉澤 和孝, 坂上 拓郎, 青木 亜美, 青木 信将, 茂呂 寛, 小屋 俊之, 菊地 利明

    日本呼吸器学会誌   7 ( 増刊 )   186 - 186   2018.3

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  • 医学と医療の最前線 肺非結核性抗酸菌症の最前線

    菊地 利明, 坂上 拓郎, 茂呂 寛

    日本内科学会雑誌   107 ( 2 )   292 - 297   2018.2

  • Usefulness of EBUS-TBNA in the staging of lung cancer in patients with sarcoidosis and sarcoid reactions

    Ichikawa, K., Watanabe, S., Kondo, R., Shoji, S., Aoki, N., Ohshima, Y., Sakagami, T., Moro, H., Koya, T., Kikuchi, T.

    Japanese Journal of Lung Cancer   58 ( 2 )   2018

  • 臨床検体を用いた血中(1-3)-β-D-グルカン測定キット国内外4種類の比較検討

    永野啓, 番場祐基, 尾方英至, 袴田真理子, 島津翔, 小泉健, 青木信将, 茂呂寛, 菊地利明

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集   67th-65th   2018

  • 自己免疫疾患に対して免疫抑制療法中の患者におけるサイトメガロウイルス感染のリスク因子の検討

    尾方英至, 里方真理子, 番場祐基, 小泉健, 青木信将, 津畑千佳子, 坂上亜希子, 佐藤瑞穂, 茂呂寛, 菊地利明

    日本化学療法学会雑誌   66 ( Supplement-A )   2018

  • 市中病院における医療介護関連肺炎の治療状況

    小泉健, 近幸吉, 里方真理子, 尾方英至, 番場祐基, 青木信将, 青木信将, 張仁美, 津畑千佳子, 坂上亜希子, 佐藤瑞穂, 茂呂寛, 田邊嘉也, 塚田弘樹, 長谷川隆志, 鈴木榮一, 菊地利明

    日本化学療法学会雑誌   66 ( Supplement-A )   2018

  • 壊死性気管気管支炎の病像を呈した気管気管支アスペルギルス症の2例

    尾方英至, 青木信将, 袴田真理子, 永野啓, 島津翔, 番場祐基, 小泉健, 張仁美, 佐藤瑞穂, 坂上亜希子, 茂呂寛, 菊地利明

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集   67th-65th   2018

  • 多系統萎縮症患者に合併した睡眠関連呼吸障害の経時的変化の検討

    大嶋 康義, 中山 秀章, 松山 菜穂, 穂苅 諭, 渡部 聡, 坂上 拓郎, 茂呂 寛, 小屋 俊之, 菊地 利明, 下畑 享良

    日本睡眠学会定期学術集会プログラム・抄録集   42回   180 - 180   2017.6

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  • 肺抗酸菌症 病態解析 抗IFN-γ自己抗体陽性播種性非結核性抗酸菌症の臨床表現型

    青木 亜美, 坂上 拓郎, 吉澤 和孝, 島 賢治郎, 青木 信将, 茂呂 寛, 田邊 嘉也, 小屋 俊之, 長谷川 隆志, 菊地 利明

    日本呼吸器学会誌   6 ( 増刊 )   121 - 121   2017.3

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  • メガリンを標的とした、バンコマイシン腎障害の予防及び早期検査法の開発

    青木 信将, 小泉 健, 津畑 千佳子, 佐藤 瑞穂, 坂上 亜希子, 茂呂 寛, 田邊 嘉也, 菊地 利明, 斎藤 亮彦

    日本化学療法学会雑誌   65 ( Suppl.A )   281 - 281   2017.3

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  • 菌血症・敗血症の急性期における鉄代謝 鉄調節因子Hepcidin-25の動態をふまえて

    茂呂 寛, 番場 祐基, 小泉 健, 青木 信将, 林 正周, 坂上 拓郎, 小屋 俊之, 田邊 嘉也, 菊地 利明

    感染症学雑誌   91 ( 臨増 )   366 - 366   2017.3

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  • 肺抗酸菌症 病態解析 肺MAC症におけるサイトカインの網羅的解析

    番場 祐基, 茂呂 寛, 青木 信将, 朝川 勝明, 林 正周, 大嶋 康義, 渡部 聡, 坂上 拓郎, 阿部 徹哉, 小屋 俊之, 高田 俊範, 菊地 利明

    日本呼吸器学会誌   6 ( 増刊 )   121 - 121   2017.3

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  • わが国における成人市中肺炎の原因微生物の変遷(Meta-analysis and systematic review)

    藤倉 雄二, 茂呂 寛, 堀田 信之, 丸山 貴也, 松本 哲哉, 今村 圭文, 川名 明彦, 河野 茂

    感染症学雑誌   91 ( 臨増 )   312 - 312   2017.3

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  • 2015/2016シーズンにおけるインフルエンザ肺炎の臨床的検討

    林 正周, 青木 信将, 坂上 拓郎, 茂呂 寛, 小屋 俊之, 田邊 嘉也, 長谷川 隆志, 斎藤 玲子, 鈴木 榮一, 菊地 利明

    感染症学雑誌   91 ( 1 )   105 - 105   2017.1

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  • 自己免疫性肺胞蛋白症に播種性帯状疱疹を合併した1例

    吉澤 和孝, 青木 亜美, 林 正周, 青木 信将, 茂呂 寛, 田邊 嘉也, 坂上 拓郎, 小屋 俊之, 菊地 利明

    感染症学雑誌   91 ( 1 )   121 - 122   2017.1

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  • 脾機能低下との関連が示唆されたCapnocytophaga感染症による電撃性紫斑病の1例

    青木 信将, 茂呂 寛, 田邊 嘉也, 長谷川 隆志, 鈴木 栄一, 菊地 利明

    感染症学雑誌   91 ( 1 )   123 - 124   2017.1

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  • 当院における抗MRSA薬の薬剤感受性推移と測定法による影響

    横山 和弘, 草間 文子, 小林 めぐみ, 吉田 彩, 近藤 千草, 古川 久美子, 町田 良子, 高野 操, 茂呂 寛, 松戸 隆之, 曽根 博仁

    新潟医学会雑誌   131 ( 1 )   58 - 59   2017.1

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  • 高齢者肺炎入院症例のADL低下の原因の検討

    小泉健, 近幸吉, 里方真理子, 尾方英至, 番場祐基, 青木信将, 張仁美, 津畑千佳子, 坂上亜希子, 佐藤瑞穂, 茂呂寛, 田邊嘉也, 塚田弘樹, 長谷川隆志, 鈴木榮一, 菊地利明

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集   66th-64th   2017

  • 菌血症・敗血症の急性期における鉄代謝~鉄調節因子Hepcidin-25の動態をふまえて

    茂呂寛, 番場祐基, 小泉健, 青木信将, 林正周, 坂上拓郎, 小屋俊之, 田邊嘉也, 菊地利明

    日本化学療法学会雑誌   65 ( Supplement-A )   2017

  • 肺MAC症におけるサイトカインの網羅的解析

    番場祐基, 茂呂寛, 青木信将, 朝川勝明, 林正周, 大嶋康義, 渡部聡, 坂上拓郎, 阿部徹哉, 小屋俊之, 高田俊範, 菊地利明

    日本呼吸器学会誌(Web)   6   2017

  • 胸部放射線治療後に合併した慢性進行性肺アスペルギルス症の2例 Reviewed

    上野 浩志, 坂上 拓郎, 大嶋 康義, 渡部 聡, 茂呂 寛, 菊地 利明

    日本呼吸器学会誌   5 ( 6 )   341 - 345   2016.11

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    症例1は75歳、男性。症例2は64歳、男性。いずれも、術後再発非小細胞肺癌に対する胸部照射後に出現した浸潤影を放射線肺炎と診断し、ステロイド治療を行った。陰影は急速に増大したために抗菌薬治療を行ったが不応性であった。喀痰または肺洗浄検体よりアスペルギルス属を検出し、その後長期にわたる抗真菌薬治療を必要とした。呼吸器内科医として日常遭遇する可能性が高く、鑑別診断に慎重を要する2症例と考えられ報告する。(著者抄録)

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  • 気管支温熱療法を施行した重症気管支喘息の1例

    林 正周, 渡邊 伸, 佐藤 美由紀, 穂苅 諭, 近藤 利恵, 渡部 聡, 青木 信将, 大嶋 康義, 坂上 拓郎, 阿部 徹哉, 茂呂 寛, 小屋 俊之, 菊地 利明

    気管支学   38 ( 4 )   347 - 347   2016.7

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  • 抗IFN-γ自己抗体価と播種性非結核性抗酸菌症の病勢

    青木 亜美, 坂上 拓郎, 島 賢治郎, 青木 信将, 茂呂 寛, 田邊 嘉也, 小屋 俊之, 各務 博, 菊地 利明, 長谷 衣佐乃, 神白 麻衣子, 田中 健之, 小泉 祐介

    感染症学雑誌   90 ( 3 )   411 - 411   2016.5

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  • 当院における胸水貯留例に対する局所麻酔下胸腔鏡検査の有用性と安全性の検討

    吉澤 和孝, 近藤 利恵, 佐藤 美由紀, 上野 浩志, 穂苅 諭, 朝川 勝明, 林 正周, 青木 信将, 岡島 正明, 大嶋 康義, 渡邊 伸, 渡部 聡, 坂上 拓郎, 阿部 徹哉, 茂呂 寛, 小屋 俊之, 田中 純太, 森山 寛史, 菊地 利明, 田島 俊児

    気管支学   38 ( Suppl. )   S271 - S271   2016.5

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  • 当院におけるEBUS-TBNAによるサルコイドーシス診断の後方視的検討

    林 正周, 上野 浩志, 吉澤 和孝, 佐藤 美由紀, 穂苅 諭, 青木 信将, 朝川 勝明, 大嶋 康義, 岡島 正明, 近藤 利恵, 渡邊 伸, 渡部 聡, 坂上 拓郎, 阿部 徹哉, 茂呂 寛, 小屋 俊之, 田中 純太, 森山 寛史, 菊地 利明, 田島 俊児

    気管支学   38 ( Suppl. )   S197 - S197   2016.5

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  • 生体肺移植後の閉塞性細気管支炎症候群に合併した肺アスペルギルス症の1例

    有田 将史, 林 正周, 青木 信将, 坂上 拓郎, 茂呂 寛, 小屋 俊之, 田邊 嘉也, 各務 博, 長谷川 隆志, 鈴木 榮一, 菊地 利明

    感染症学雑誌   90 ( 3 )   389 - 390   2016.5

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  • 気管支鏡施行時の大量出血により気道確保を要した症例の検討

    近藤 利恵, 佐藤 美由紀, 吉澤 和孝, 上野 浩志, 穂苅 諭, 朝川 勝明, 林 正周, 青木 信将, 岡島 正明, 大嶋 康義, 渡邊 伸, 渡部 聡, 坂上 拓郎, 阿部 徹哉, 茂呂 寛, 小屋 俊之, 森山 寛史, 菊地 利明

    気管支学   38 ( Suppl. )   S256 - S256   2016.5

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  • 非結核性抗酸菌症の今日的問題 抗IFN-γ自己抗体価と播種性非結核性抗酸菌症の病勢に関する検討

    青木 亜美, 坂上 拓郎, 島 賢治郎, 茂呂 寛, 田邊 嘉也, 小屋 俊之, 各務 博, 菊地 利明, 長谷 衣佐乃, 神白 麻衣子, 田中 健之, 小泉 祐介, 田村 厚久

    日本呼吸器学会誌   5 ( 増刊 )   147 - 147   2016.3

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  • 敗血症における鉄代謝と鉄調節因子Hepcidin-25の動態について

    茂呂 寛, 青木 信将, 坂上 拓郎, 小屋 俊之, 田邊 嘉也, 菊地 利明

    感染症学雑誌   90 ( 臨増 )   337 - 337   2016.3

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  • 抗IFN-γ自己抗体陽性播種性非結核性抗酸菌症の臨床表現型

    青木 亜美, 坂上 拓郎, 島 賢治郎, 青木 信将, 茂呂 寛, 田邊 嘉也, 小屋 俊之, 菊地 利明

    結核   91 ( 3 )   401 - 401   2016.3

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  • MRSAのVCMにおける薬剤感受性の検討

    草間 文子, 横山 和弘, 小林 めぐみ, 古川 久美子, 町田 良子, 吉田 彩, 近藤 千草, 高野 操, 茂呂 寛, 曽根 博仁

    日本臨床微生物学雑誌   26 ( Suppl. )   309 - 309   2015.12

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  • 1 稀少な菌種による非結核性抗酸菌症の2例 (Ⅰ.一般演題, 第53回新潟化学療法研究会)

    茂呂 寛, 野嵜 幸一郎, 朝川 勝明, 三浦 理, 田邊 嘉也, 各務 博, 成田 一衛

    新潟医学会雑誌   129 ( 11 )   703 - 703   2015.11

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  • NTM症における今日的問題点 肺非結核性抗酸菌症、肺結核症における抗Interferon-γ自己抗体に関する検討

    青木 亜美, 坂上 拓郎, 島 賢治郎, 青木 信将, 茂呂 寛, 田邊 嘉也, 小屋 俊之, 各務 博, 成田 一衛, 星野 仁彦, 森本 耕三, 倉島 繁行

    日本呼吸器学会誌   4 ( 増刊 )   128 - 128   2015.3

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  • 2013/2014シーズンにおけるインフルエンザA/H 1N1pdm09肺炎8症例の臨床的検討

    林 正周, 坂上 拓郎, 青木 信将, 茂呂 寛, 小屋 俊之, 田邊 嘉也, 各務 博, 長谷川 隆志, 齋藤 玲子, 鈴木 榮一, 成田 一衛

    感染症学雑誌   89 ( 2 )   346 - 347   2015.3

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  • 静注用人免疫グロブリン製剤が血清(1→3)-β-Dグルカン測定結果に及ぼす影響

    茂呂 寛, 林 正周, 青木 信将, 坂上 拓郎, 小屋 俊之, 田邊 嘉也, 各務 博, 成田 一衛

    感染症学雑誌   89 ( 臨増 )   210 - 210   2015.3

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  • 肺非結核性抗酸菌症、肺結核症、健常者における抗Interferon-γ自己抗体に関する検討

    青木 亜美, 坂上 拓郎, 島 賢治郎, 青木 信将, 茂呂 寛, 田邊 嘉也, 小屋 俊之, 各務 博, 成田 一衛, 星野 仁彦, 森本 耕三, 倉島 篤行

    結核   90 ( 2 )   362 - 362   2015.2

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  • Brevibacterium luteolumによる感染性心内膜炎の1例

    草間 文子, 高野 操, 茂呂 寛, 小林 めぐみ, 横山 和弘, 吉田 彩, 町田 良子, 古川 久美子, 若杉 嵩幸, 南野 徹, 大楠 清文

    日本臨床微生物学雑誌   25 ( Suppl.1 )   230 - 230   2014.12

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  • HIV感染症の経過中に膵島関連自己抗体が陽性となった3例

    保川亮太, 細島康宏, 青木信将, 若松拓也, 石川友美, 茂呂寛, 田邊嘉也, 成田一衛, 鈴木芳樹, 斎藤亮彦

    糖尿病   57 ( 6 )   456   2014.6

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  • 腫瘍随伴症候群によるII型呼吸不全で発症した胸腺癌の1例

    佐藤 健, 木村 夕香, 宮尾 浩美, 黒羽 泰子, 小池 亮子, 斎藤 泰晴, 大平 徹郎, 朝川 勝明, 三浦 理, 茂呂 寛, 各務 博, 若杉 尚宏, 金澤 雅人, 河内 泉, 西澤 正豊

    新潟医学会雑誌   128 ( 6 )   280 - 280   2014.6

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  • インフルエンザワクチン接種後に好酸球性血管浮腫を来した1例

    林 正周, 小屋 俊之, 堀 好寿, 青木 信将, 坂上 拓郎, 茂呂 寛, 田邊 嘉也, 長谷川 隆志, 成田 一衛

    日本化学療法学会雑誌   62 ( Suppl.A )   328 - 328   2014.5

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  • 抗Interferon-γ中和自己抗体陽性の播種性非結核性抗酸菌症の検討

    坂上 拓郎, 島 賢治郎, 田邊 嘉也, 青木 信将, 茂呂 寛, 長谷川 隆志, 成田 一衛

    日本化学療法学会雑誌   62 ( Suppl.A )   388 - 388   2014.5

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  • 重篤な血小板減少を認めた急性HIV感染症の1例

    青木 亜美, 茂呂 寛, 田邊 嘉也, 成田 一衛

    感染症学雑誌   88 ( 2 )   259 - 259   2014.3

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  • 抗Interferon-γ中和自己抗体陽性の播種性非結核性抗酸菌症 新たな疾患概念

    島 賢治郎, 坂上 拓郎, 青木 信将, 茂呂 寛, 田邊 嘉也, 各務 博, 長谷川 隆志, 高田 俊範, 成田 一衛

    日本内科学会雑誌   103 ( Suppl. )   229 - 229   2014.2

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  • 播種性非結核性抗酸菌症における抗IFNγ自己抗体検出法の確立

    島 賢治郎, 坂上 拓郎, 青木 信将, 茂呂 寛, 田邊 嘉也, 鈴木 栄一, 成田 一衛, 桑原 克弘

    日本呼吸器学会誌   2 ( 増刊 )   313 - 313   2013.3

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  • 播種性非結核性抗酸菌症における抗IFNγ自己抗体検出法の確立

    島 賢治郎, 坂上 拓郎, 青木 信将, 茂呂 寛, 田邉 嘉也, 鈴木 栄一, 成田 一衛, 桑原 克弘

    感染症学雑誌   87 ( 1 )   156 - 156   2013.1

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  • A Novel Assay To Detect Neutralizing Anti-Interferon-Gamma Autoantibody In Clinical Samples With Disseminated Non-Tuberculous Mycobacterial Infection

    K. Shima, T. Sakagami, N. Aoki, H. Moro, Y. Tanabe, E. Suzuki, K. Kuwabara, I. Narita

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   187   2013

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  • テノホビルによる尿細管細胞機能障害の可逆性

    影向晃, 竹田徹朗, 田邊嘉也, 古塩奈央, 堀好寿, 青木信将, 茂呂寛, 齋藤亮彦, 成田一衛, 岡慎一

    日本エイズ学会誌   14 ( 4 )   387 - 387   2012.11

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  • 抗IFN-gamma自己抗体の存在が発症に関与したと考えられた播種性非結核性抗酸菌症の1例

    大久保 猛司, 田邊 嘉也, 小山 建一, 津畑 千佳子, 手塚 貴文, 茂呂 寛, 小屋 俊之, 各務 博, 下条 文武, 長谷川 隆志, 鈴木 栄一, 伊藤 拓緯

    結核   83 ( 2 )   131 - 131   2008.2

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  • テリスロマイシンの呼吸器感染症治療薬における位置づけ—第5土曜特集 抗菌薬 UPDATE ; 第4章 新しい抗菌薬

    青木 信樹, 茂呂 寛

    医学のあゆみ   209 ( 9 )   653 - 658   2004.5

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  • 注射用抗菌薬の投与はいつ止めるか—特集 注射用抗菌薬をどのように選び,どう使い,いつ止めるか ; 注射用抗菌薬使用のエンドポイント

    青木 信樹, 茂呂 寛

    感染と抗菌薬 = Infection and antimicrobials   7 ( 1 )   55 - 58   2004.3

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    Other Link: https://search.jamas.or.jp/link/ui/2004195777

  • プロピオン酸フルチカゾンの使用により顕在化した心不全合併のChurg-Strauss症候群の1例

    小屋 俊之, 竹本 淳紀, 保坂 公徳, 茂呂 寛, 長谷川 隆志, 鈴木 栄一, 下条 文武

    アレルギー   51 ( 11 )   1127 - 1130   2002.11

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    61歳男.気管支喘息であり,プロピオン酸フルチカゾン(フルタイド)吸入療法を導入された.以後喘息のコントロールは明らかに良好となり,ステロイド内服は減量され,その後中止となった.しかし労作時息切れ・喘鳴が出現して気管支喘息発作を疑い,吸入・点滴を行われたが改善せず胸部X線写真で鬱血性心不全の所見が認められ,又,好酸球が著増した.臨床経過より心不全を合併したChurg-Strauss症候群と診断してプレドニゾロン 60mg/日の内服を開始した.これにより末梢血の好酸球は速やかに減少し,心不全の所見も軽快して心エコー上壁運動も改善を認め,皮膚の紫斑も消失した

    DOI: 10.15036/arerugi.51.1127

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  • 筋緊張性ジストロフィー症に合併した糖尿病の2症例

    阪田 郁, 赤岩 靖久, 茂呂 寛, 金子 佳賢, 桑原 克弘, 笠井 昭男, 柄澤 良, 木村 秀樹, 鈴木 芳樹, 荒川 正昭

    新潟医学会雑誌   112 ( 10 )   650 - 650   1998.10

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Presentations

  • 院内肺炎におけるempiric therapyの最適化について Invited

    茂呂寛

    第97回日本感染症学会総会  2023.4 

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    Event date: 2023.4

    Presentation type:Symposium, workshop panel (nominated)  

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  • 教育講演4 鉄代謝からみた感染症~診断・治療への応用に向けて Invited

    茂呂寛

    第94回日本感染症学会総会・学術講演会  2020.8 

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    Event date: 2020.8

    Presentation type:Oral presentation (invited, special)  

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  • Comparison of the new Wako beta-D-glucan measurement kit and the four conventional kits for the diagnosis of the invasive fungal infections

    Bamba Y, Moro H, Nagano K, Aoki N, Koizumi T, Ohshima Y, Watanabe S, Koya T, Takada T, Kikuchi T

    29th ECCMID  2019.4 

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    Event date: 2019.4

    Language:English   Presentation type:Poster presentation  

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  • コロナ禍における呼吸器感染症への対応を考える ~レスピラトリーキノロンに期待される役割 Invited

    茂呂寛

    第52回 結核・非定型抗酸菌症治療研究会  2021.12 

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  • ランチョンセミナー8 感染症における鉄調節因⼦ ヘプシジン-25の動態 Invited

    茂呂寛

    第61回⽇本臨床化学会  2021.11 

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  • シンポジウム21「非結核性抗酸菌症ー長期管理の時代へ」 慢性閉塞性肺疾患と抗酸菌症 Invited

    茂呂寛

    第70回日本感染症学会東日本地方会学術集会  2021.10 

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  • 深在性真菌症における (1→3)β-D-グルカン検査の活用を考える Invited

    茂呂寛

    第57回 日臨技 関甲信支部・首都圏支部医学検査学会  2021.10 

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  • The hepcidin-25 and iron kinetics during the acute phase of systemic infection

    Hiroshi Moro, Yuuki Bamba, Kei Nagano, Takeshi Koizumi, Nobumasa Aoki, Yasuyoshi Ohshima, Satoshi Watanabe, Toshiyuki Koya, Toshinori Takada, Toshiaki Kikuchi

    IDWeek2018  2018 

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    Language:English  

    Venue:San Francisco  

    一般演題

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  • 有機リン中毒患者に合併した肺炎の起因菌に関する後方視的検討

    番場 祐基, 山岸 郁美, 佐藤 和茂, 青木 志門, 袴田 真理子, 尾方 英至, 柴田 怜, 張 仁美, 佐藤 瑞穂, 青木 信将, 茂呂 寛, 小屋 俊之, 菊地 利明

    日本感染症学会総会・学術講演会・日本化学療法学会学術集会合同学会プログラム・抄録集  2023.3  日本感染症学会・日本化学療法学会

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    Event date: 2023.3

    Language:Japanese  

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  • 当院における腹膜透析(PD)関連抗酸菌感染症について

    山岸 郁美, 佐藤 和茂, 袴田 真理子, 番場 祐基, 尾方 英至, 柴田 怜, 張 仁美, 佐藤 瑞穂, 青木 信将, 茂呂 寛, 小屋 俊之, 菊地 利明

    日本感染症学会総会・学術講演会・日本化学療法学会学術集会合同学会プログラム・抄録集  2023.3  日本感染症学会・日本化学療法学会

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    Event date: 2023.3

    Language:Japanese  

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  • 医療介護関連肺炎のADLによる死亡率の変化の検討

    小泉 健, 島津 翔, 山岸 郁美, 佐藤 和茂, 青木 志門, 宇井 雅博, 番場 祐基, 袴田 真理子, 尾方 英至, 柴田 怜, 張 仁美, 佐藤 瑞穂, 青木 信将, 茂呂 寛, 小屋 俊之, 菊地 利明, 近 幸吉, 原 勝人

    感染症学雑誌  2022.3  (一社)日本感染症学会

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    Event date: 2022.3

    Language:Japanese  

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  • 当施設における肺非結核抗酸菌症の状況 治療の状況を中心に

    青木 志門, 小泉 健, 阿部 静太郎, 袴田 真理子, 永野 啓, 柴田 怜, 青木 信将, 茂呂 寛, 小屋 俊之, 菊地 利明

    日本内科学会雑誌  2021.2  (一社)日本内科学会

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    Event date: 2021.2

    Language:Japanese  

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  • 誤嚥性肺炎の禁食期間と予後の検討

    小泉 健, 近 幸吉, 原 勝人, 島津 翔, 尾方 英至, 永野 啓, 里方 真理子, 番場 祐基, 張 仁美, 青木 信将, 佐藤 瑞穂, 坂上 亜希子, 茂呂 寛, 菊地 利明, 長谷川 隆志, 鈴木 榮一, 田邊 嘉也, 塚田 弘樹

    感染症学雑誌  2019.3  (一社)日本感染症学会

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    Event date: 2019.3

    Language:Japanese  

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  • 肺MAC症の経過における鉄代謝の動態について

    茂呂 寛, 番場 祐基, 小泉 健, 大嶋 康義, 菊地 利明

    結核  2019.3  (一社)日本結核・非結核性抗酸菌症学会

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    Event date: 2019.3

    Language:Japanese  

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  • 血流感染症における鉄制御因子Lipocalin2の動態について

    茂呂 寛, 番場 祐基, 永野 啓, 小泉 健, 青木 信将, 菊地 利明

    感染症学雑誌  2019.3  (一社)日本感染症学会

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    Event date: 2019.3

    Language:Japanese  

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  • 臨床検体を用いた血中(1-3)-β-D-グルカン測定キット国内外4種類の比較検討

    永野 啓, 番場 祐基, 尾方 英至, 袴田 真理子, 島津 翔, 小泉 健, 青木 信将, 茂呂 寛, 菊地 利明

    感染症学雑誌  2019.1  (一社)日本感染症学会

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    Event date: 2019.1

    Language:Japanese  

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  • 壊死性気管気管支炎の病像を呈した気管気管支アスペルギルス症の2例

    尾方 英至, 青木 信将, 袴田 真理子, 永野 啓, 島津 翔, 番場 祐基, 小泉 健, 張 仁美, 佐藤 瑞穂, 坂上 亜希子, 茂呂 寛, 菊地 利明, 中枝 武司, 和田 庸子, 成田 一衛

    感染症学雑誌  2019.1  (一社)日本感染症学会

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    Event date: 2019.1

    Language:Japanese  

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  • 準高齢者・高齢者・超高齢者の肺炎入院症例の予後の検討

    島津 翔, 小泉 健, 袴田 真理子, 永野 啓, 尾方 英至, 張 仁美, 青木 信将, 佐藤 瑞穂, 坂上 亜希子, 茂呂 寛, 菊地 利明, 長谷川 隆志, 鈴木 榮一, 近 幸吉, 原 勝人, 石塚 修, 田邊 嘉也, 西堀 武明, 塚田 弘樹

    感染症学雑誌  2019.1  (一社)日本感染症学会

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    Event date: 2019.1

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  • HIV感染症患者の睡眠障害 多角的視点からの検討

    中川 雄真, 茂呂 寛, 村松 芳幸, 川口 玲, 石田 順子, 野田 順子, 菊地 利明

    日本エイズ学会  2018.11  (一社)日本エイズ学会

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • CRP上昇を伴わない黄色ブドウ球菌感染症を繰り返し抗IL-6自己抗体の存在が疑われた1例

    吉澤 和孝, 坂上 拓郎, 番場 祐基, 青木 亜美, 林 正周, 青木 信将, 茂呂 寛, 田邊 嘉也, 長谷川 隆志, 小屋 俊之, 菊地 利明

    感染症学雑誌  2018.5  (一社)日本感染症学会

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    Event date: 2018.5

    Language:Japanese  

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  • 真菌血流感染症における敗血症バイオマーカーPresepsinの挙動とその有用性

    番場 祐基, 茂呂 寛, 里方 真理子, 尾方 英至, 小泉 健, 青木 信将, 林 正周, 坂上 拓郎, 小屋 俊之, 菊地 利明

    感染症学雑誌  2018.5  (一社)日本感染症学会

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    Event date: 2018.5

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  • 深在性真菌症における各β-D-グルカン測定試薬の比較

    番場 祐基, 茂呂 寛, 里方 真理子, 尾方 英至, 小泉 健, 青木 信将, 林 正周, 坂上 拓郎, 小屋 俊之, 菊地 利明

    日本化学療法学会雑誌  2018.4  (公社)日本化学療法学会

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    Event date: 2018.4

    Language:Japanese  

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  • 敗血症診療におけるバイオマーカーの役割

    茂呂寛

    第45回日本集中治療医学会学術集会  2018 

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    Language:Japanese  

    Venue:千葉  

    特別講演

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  • 当施設におけるMRSA診療の現状と課題

    茂呂寛

    新潟MRSAフォーラム2018  2018 

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    Venue:新潟  

    特別講演

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  • 感染症における鉄代謝の動態〜診断・治療への応用に向けて〜

    茂呂寛

    第734回新潟医学会  2018 

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    Venue:新潟  

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  • 感染症と抗菌薬選択のロジック

    茂呂寛

    日本薬学会関東支部 薬剤師向け研修講演会  2018 

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    Venue:新潟  

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  • 肺炎診療アップデート〜ガイドライン改訂をふまえて〜

    茂呂寛

    第12回下越エリア感染症勉強会  2018 

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    Venue:新潟  

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  • NHCAP診療アップデート〜ガイドライン改訂をふまえて〜

    茂呂寛

    第13回東日本NHCAP懇話会  2018 

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    Venue:新潟  

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  • 抗真菌薬適正使用支援におけるβ-D-グルカン検査活用のポイント

    茂呂寛

    第65回日本臨床検査医学会学術集会  2018 

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    Venue:東京  

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  • 重症感染症におけるプレセプシンの有用性

    茂呂寛

    第65回日本臨床検査医学会学術集会  2018 

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    Venue:東京  

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  • 抗菌薬の適正使用とは〜薬剤耐性対策アクションプランをふまえて

    茂呂寛

    平成30年度専門医共通講習会  2018 

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    Venue:新潟  

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Research Projects

  • 非加熱血液凝固因子製剤によるHIV感染血友病患者の長期療養体制構築に関する患者参加型研究

    2023.4 - 2024.4

    System name:厚生労働行政推進調査事業費補助金

    Research category:エイズ対策政策研究事業

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    Authorship:Coinvestigator(s) 

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  • 国内流行HIV及びその薬剤耐性株の長期的動向把握に関する研究

    2023.4 - 2024.3

    System name:日本医療研究開発機構 AMED

    Research category:エイズ対策実用化研究事業

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  • HIV感染症の医療体制の整備に関する研究

    2023.4 - 2024.3

    System name:厚生労働行政推進調査事業費補助金

    Research category:エイズ対策政策研究事業

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  • 非加熱血液凝固因子製剤によるHIV感染血友病等患者に合併する 腫瘍への包括的対策に関する研究

    2023.4 - 2024.3

    System name:厚生労働行政推進調査事業費補助金

    Research category:エイズ対策政策研究事業

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  • Usefulness of CXCL10 as a biomarker for pulmonary MAC disease

    Grant number:20K08536

    2020.4 - 2024.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

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  • リスクアセスメントとオーラルリテラシーを向上する誤嚥性肺炎の危険予知システム開発

    Grant number:19H03958

    2019.4 - 2023.3

    System name:科学研究費助成事業 基盤研究(B)

    Research category:基盤研究(B)

    Awarding organization:日本学術振興会

    竹中 彰治, 定方 美恵子, 山崎 達也, 土門 久哲, 清水 詩子, 黒瀬 雅之, 茂呂 寛, 野杁 由一郎, 佐藤 信枝

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    Authorship:Coinvestigator(s) 

    Grant amount:\17420000 ( Direct Cost: \13400000 、 Indirect Cost:\4020000 )

    地域包括ケアシステムの確立が推進される中で、在宅高齢者の身体状態の変化を察知するリスクアセスメントが重要となっている。本研究の目的は、これからの医療の中心を担う看護師が、高齢者の協力度に関係なく、誤嚥性肺炎のリスクの進行を予知できる科学的評価システムを開発することである。これまで、看護師が経験の中で見抜いていたリスク評価に、科学的かつ客観的パラメータを追加することで、在宅介護のエビデンスの裏付けが可能となる。これまでのバイオフィルム研究の成果を基に、誤嚥性肺炎のリスク上昇を唾液中の細菌検査と口腔細菌の血清抗体価検査から予知する手法の開発に取り組む。 さらに、嚥下機能の低下をビジュアル化するウェアラブル嚥下機能評価機器を開発する。科学的手法を用いた“健康状態の見える化”により、看護師のリスクアセスメント力の強化とオーラルリテラシーの向上が期待できる。
    初年度は、解析対象となる肺炎患者の血清抗体を集めるため、本学倫理審査委員会の承認を得るとともに、バイオバンクおよび新潟市の中核病院と共同研究について協議を行なった。
    入院による治療が必要と判断された10名の患者を対象に、治療上必要な血液検査を行うタイミングで残余検体を回収した。国内外で販売されているCRP迅速診断キットを用いてCRP値(定性)を測定し、定量値との相関性を検討した。その結果、すべてのキットが90%以上の高い相関性を示したが、Actim CRPは1-4, 4-8, >8mg/dlの3段階判定において、98%の高い相関性を示した。しかし、これらの迅速診断キットは、簡便性(操作の手順)と判定方法に課題があり、在宅で応用するには難がある。簡便かつ、判定が用意な高感度カセットの開発に取り組む必要がある。

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  • Mechanisms of iron metabolism by hepcidin and its role in acute phase of sepsis.

    Grant number:17K10015

    2017.4 - 2020.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Moro Hiroshi

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    During the acute phase of infectious disease with severe inflammation, iron levels were immediately decreased along with enhanced production of hepcidin. Additionally, each behavior of hepcidin and lipocalin 2 may suggest a different role during the acute phase of infection. Understanding of iron metabolism is expected to be applied in diagnosis and treatment

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  • Iron status and cytokine profile in pulmonary MAC disease

    Grant number:26461157

    2014.4 - 2017.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Research category:Grant-in-Aid for Scientific Research (C)

    Awarding organization:Japan Society for the Promotion of Science

    Moro Hiroshi

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    Authorship:Principal investigator 

    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

    Patients with fibrocavitary MAC lung disease tend to have elevated inflammatory markers, poor nutritional status and deterioration of iron status, and long-term management is necessary. Serum IP-10 levels were significantly increased in the cavitary form, and it is significantly correlated with CRP, Fe, pre-Alb. With prolonged pro-inflammatory state of pulmonary MAC disease, IP-10 might associated with comorbid poor nutritional status and deterioration of iron status, and it might reflect the disease forms and severity of pulmonary MAC disease, as well as pulmonary tuberculosis.

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  • 認知症に対応し在宅医療を支援する血中抗体価を指標とした誤嚥性肺炎診断キットの開発

    Grant number:22K19667

    2022.6 - 2024.3

    System name:科学研究費助成事業 挑戦的研究(萌芽)

    Research category:挑戦的研究(萌芽)

    Awarding organization:日本学術振興会

    竹中 彰治, 清水 詩子, 茂呂 寛, 野杁 由一郎

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    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

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  • Development of a rapid diagnostic kit for determining the risk of aspiration pneumonia corresponding to dementia for visiting nurses

    Grant number:20K21702

    2020.7 - 2022.3

    System name:Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)

    Research category:Grant-in-Aid for Challenging Research (Exploratory)

    Awarding organization:Japan Society for the Promotion of Science

    Takenaka Shoji

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    Authorship:Coinvestigator(s) 

    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

    The purpose of this study was to develop a scientific evaluation system that does not require special equipment and does not depend on the degree of cooperation of patients and can determine the risk of disease onset at home. And this study aimed to support the risk assessment ability of visiting nurses who are active in community-based comprehensive care. We have developed a rapid diagnostic cassette that determines the CRP value from a small amount of blood from the fingertip. This cassette is based on the principle of an immunochromatography method that utilizes the color development phenomenon of colloidal gold, and can be determined by 10 ul of whole blood collected from the fingertip with a capillary. This cassette can diagnose 20 mg and 60 mg/L in 5 minutes and 4 mg/L in 10 minutes. No special equipment is required for the measurement, and the value measured by this cassette was highly consistent with the clinical laboratory values performed in the hospital.

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