Updated on 2026/04/23

写真a

 
KANEKO Yoshikatsu
 
Organization
Academic Assembly Institute of Medicine and Dentistry Health Sciences Professor
Graduate School of Medical and Dental Sciences Center of Nephrology Lecturer
Faculty of Medicine Professor
Title
Professor
External link

Degree

  • 博士（医学） ( 2001.3   新潟大学 )

Research Areas

  • Life Science / General internal medicine  / 老年医学

  • Life Science / Immunology

  • Life Science / Nephrology

Research History

  • Niigata University   Health Sciences, Institute of Medicine and Dentistry, Academic Assembly   Professor

    2026.4

  • Niigata University   Faculty of Medicine   Professor

    2026.4

  • Niigata University   Institute of Nephrology, Graduate School of Medical and Dental Sciences   Professor

    2026.4

  • Niigata University   Faculty of Medicine Institute of Nephrology   Lecturer

    2016.4 - 2026.3

  • Niigata University   Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Homeostatic Regulation and Developments   Lecturer

    2015.4 - 2016.3

  • Niigata University   Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Homeostatic Regulation and Developments   Assistant Professor

    2014.8 - 2015.3

  • Niigata University   University Medical and Dental Hospital Nephrology and Rheumatology   Assistant Professor

    2012.11 - 2014.7

  • Niigata University   University Medical and Dental Hospital Internal Medicine II   Assistant Professor

    2011.5 - 2012.11

  • Niigata University   Graduate School of Medical and Dental Sciences   Specially Appointed Assistant Professor

    2010.10 - 2011.4

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Qualification acquired

  • Doctor

 

Papers

  • Mood Disorder in Systemic Lupus Erythematosus Induced by Antiribosomal P Protein Antibodies Associated with Decreased Serum and Brain Tryptophan Reviewed International journal

    Takamasa Cho, Hiroe Sato, Ayako Wakamatsu, Riuko Ohashi, Yoichi Ajioka, Toshio Uchiumi, Shin Goto, Ichiei Narita, Yoshikatsu Kaneko

    The Journal of Immunology   206 ( 8 )   1729 - 1739   2021.4

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：The American Association of Immunologists  

    Antiribosomal P protein (anti-P) autoantibodies commonly develop in patients with systemic lupus erythematosus. We have previously established hybridoma clones producing anti-P mAbs. In this study, we explored the pathogenesis of behavioral disorders induced by anti-P Abs using these mAbs. New Zealand Black × New Zealand White F1, New Zealand White, C57BL/6, and BALB/c mice were treated with 1 mg of anti-P Abs once every 2 wk. The behavioral disorder was evaluated by the tail suspension test, forced swim test, and open field test. Following administration of anti-P Abs, New Zealand Black × New Zealand White F1 and C57BL/6 mice developed depressive behavior and showed increased anxiety with elevated serum TNF-α and IL-6 levels. Anti-P Abs were not deposited in the affected brain tissue; instead, this mood disorder was associated with lower serum and brain tryptophan concentrations. Tryptophan supplementation recovered serum tryptophan levels and prevented the behavioral disorder. TNF-α and IL-6 were essential for the decreased serum tryptophan and disease development, which were ameliorated by treatment with anti-TNF-α neutralizing Abs or dexamethasone. Peritoneal macrophages from C57BL/6 mice produced TNF-α, IL-6, and IDO-1 via interaction with anti-P Abs through activating FcγRs, which were required for disease development. IVIg, which has an immunosuppressive effect partly through the regulation of FcγR expression, also prevented the decrease in serum tryptophan and disease development. Furthermore, serum tryptophan concentrations were decreased in the sera of systemic lupus erythematosus patients with anti-P Abs, and lower tryptophan levels correlated with disease activity. Our study revealed some of the molecular mechanisms of mood disorder induced by anti-P Abs.

    DOI： 10.4049/jimmunol.2000260

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  • Brain‐derived neurotrophic factor is associated with sarcopenia and frailty in Japanese hemodialysis patients Reviewed

    Satoru Miyazaki, Noriaki Iino, Ryo Koda, Ichiei Narita, Yoshikatsu Kaneko

    Geriatrics & Gerontology International   21 ( 1 )   27 - 33   2021.1

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    AIM: We evaluated several sarcopenia-related hormones, cytokines and uremic toxins to identify the humoral factors associated with sarcopenia and frailty in Japanese hemodialysis patients. METHODS: Twenty Japanese patients aged ≥65 years who underwent maintenance hemodialysis therapy at Uonuma Kikan Hospital for more than 6 months were included in this retrospective cross-sectional study. Clinical data, including physical function and mental state, were obtained from the clinical records collected during the regular evaluation at the beginning of each hemodialysis therapy session, 3 days after the previous hemodialysis therapy. The diagnosis of sarcopenia and frailty was based on the Asian Working Group for Sarcopenia 2019 and the Japanese version of the Cardiovascular Health Study, respectively. The mental state of patients was evaluated using the Japanese version of the Patient Health Questionnaire 9 (J-PHQ-9). RESULTS: In univariate analyses, plasma brain-derived neurotrophic factor (BDNF) levels were significantly lower in patients with severe sarcopenia and frailty. The plasma BDNF concentration was correlated with muscle strength and physical performances, such as the 6-m walk test, Short Physical Performance Battery and 5-time chair stand test. BDNF was also correlated with body weight, hemodialysis vintage, and serum levels of total protein and indoxyl sulfate but not with body mass index, appendicular skeletal muscle mass, serum interleukin 6 levels, or J-PHQ-9 scores. The odds ratio per 100 pg/mL of BDNF for the prevalence of frailty was 0.353. CONCLUSIONS: BDNF is associated with decreased physical performance and the prevalence of severe sarcopenia and frailty in Japanese maintenance hemodialysis patients. Geriatr Gerontol Int 2021; 21: 27-33.

    DOI： 10.1111/ggi.14089

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ggi.14089

  • Attenuated Macrophage Infiltration in Glomeruli of Aged Mice Resulting in Ameliorated Kidney Injury in Nephrotoxic Serum Nephritis. Reviewed

    Kaneko Y, Cho T, Sato Y, Goto K, Yamamoto S, Goto S, Madaio MP, Narita I

    The journals of gerontology. Series A, Biological sciences and medical sciences   73 ( 9 )   1178 - 1186   2018.8

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/gerona/gly019

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  • Kidney morphological parameters measured using noncontrast-enhanced steady-state free precession MRI with spatially selective inversion recovery pulse correlate with eGFR in patients with advanced CKD Reviewed

    Tadashi Otsuka, Yoshikatsu Kaneko, Yuya Sato, Ryohei Kaseda, Ryuji Aoyagi, Suguru Yamamoto, Shin Goto, Ichiei Narita

    Clinical and Experimental Nephrology   22 ( 1 )   45 - 54   2018.2

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Tokyo  

    DOI： 10.1007/s10157-017-1413-x

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  • Prolactin Upregulates Female-Predominant P450 Gene Expressions and Downregulates Male-Predominant Gene Expressions in Mouse Liver Reviewed

    Yuya Sato, Yoshikatsu Kaneko, Takamasa Cho, Kei Goto, Tadashi Otsuka, Suguru Yamamoto, Shin Goto, Hiroki Maruyama, Ichiei Narita

    DRUG METABOLISM AND DISPOSITION   45 ( 6 )   586 - 592   2017.6

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1124/dmd.116.074658

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  • Extracapillary proliferation and arteriolar hyalinosis are associated with long-term kidney survival in IgA nephropathy Reviewed

    Yoshikatsu Kaneko, Kazuhiro Yoshita, Emiko Kono, Yumi Ito, Naofumi Imai, Suguru Yamamoto, Shin Goto, Ichiei Narita

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   20 ( 4 )   569 - 577   2016.8

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10157-015-1185-0

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  • Leptin deficiency down-regulates IL-23 production in glomerular podocytes resulting in an attenuated immune response in nephrotoxic serum nephritis Reviewed

    Kei Goto, Yoshikatsu Kaneko, Yuya Sato, Tadashi Otsuka, Suguru Yamamoto, Shin Goto, Keiko Yamamoto, Tadashi Yamamoto, Hiroshi Kawachi, Michael P. Madaio, Ichiei Narita

    INTERNATIONAL IMMUNOLOGY   28 ( 4 )   197 - 208   2016.4

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/intimm/dxv067

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  • Upregulation of prolactin receptor in proximal tubular cells was induced in cardiac dysfunction model mice Reviewed

    Yohei Tsuchida, Yoshikatsu Kaneko, Tadashi Otsuka, Kei Goto, Akihiko Saito, Keiko Yamamoto, Tadashi Yamamoto, Ichiei Narita

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   18 ( 1 )   65 - 74   2014.2

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10157-013-0820-x

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  • Integrin alpha 1/beta 1 and alpha 2/beta 1 as a receptor for IgA1 in human glomerular mesangial cells in IgA nephropathy Reviewed

    Yoshikatsu Kaneko, Tadashi Otsuka, Yohei Tsuchida, Fumitake Gejyo, Ichiei Narita

    INTERNATIONAL IMMUNOLOGY   24 ( 4 )   219 - 232   2012.4

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/intimm/dxr125

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  • Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation Reviewed

    Yoshikatsu Kaneko, Falk Nimmerjahn, Jeffrey V. Ravetch

    SCIENCE   313 ( 5787 )   670 - 673   2006.8

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1126/science.1129594

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  • Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors Reviewed

    Y Kaneko, F Nimmerjahn, MP Madaio, JV Ravetch

    JOURNAL OF EXPERIMENTAL MEDICINE   203 ( 3 )   789 - 797   2006.3

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1084/jem.20051900

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  • Monocyte chemoattractant protein-1 A-2518G gene polymorphism and renal survival of Japanese patients with immunoglobulin A nephropathy Reviewed

    Honami Mori, Yoshikatsu Kaneko, Ichiei Narita, Shin Goto, Noriko Saito, Daisuke Kondo, Fuminori Sato, Junya Ajiro, Daisuke Saga, Asa Ogawa, Minoru Sakatsume, Mitsuhiro Ueno, Kaoru Tabei, Fumitake Gejyo

    Clinical and Experimental Nephrology   9 ( 4 )   297 - 303   2005.12

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10157-005-0375-6

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  • Natural saline-flush is sufficient to maintain patency of immobilized-urokinase double-lumen catheter used to provide temporary blood access for hemodialysis Reviewed

    Y Kaneko, M Iwano, H Yoshida, M Kosuge, S Ito, Narita, I, F Gejyo, M Suzuki

    BLOOD PURIFICATION   22 ( 5 )   473 - 479   2004

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000081811

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  • Transferrin saturation versus reticulocyte hemoglobin content for iron deficiency in Japanese hemodialysis patients Reviewed

    Y Kaneko, S Miyazaki, Y Hirasawa, F Gejyo, M Suzuki

    KIDNEY INTERNATIONAL   63 ( 3 )   1086 - 1093   2003.3

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1046/j.1523-1755.2003.00826.x

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  • Macrophage metalloelastase as a major factor for glomerular injury in anti-glomerular basement membrane nephritis Reviewed

    Y Kaneko, M Sakatsume, YS Xie, T Kuroda, M Igashima, Narita, I, F Gejyo

    JOURNAL OF IMMUNOLOGY   170 ( 6 )   3377 - 3385   2003.3

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  • Augmentation of V alpha 14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis Reviewed

    Y Kaneko, M Harada, T Kawano, M Yamashita, Y Shibata, F Gejyo, T Nakayama, M Taniguchi

    JOURNAL OF EXPERIMENTAL MEDICINE   191 ( 1 )   105 - 114   2000.1

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1084/jem.191.1.105

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  • Antitumor cytotoxicity mediated by ligand-activated human V alpha 24 NKT cells Reviewed

    T Kawano, T Nakayama, N Kamada, Y Kaneko, M Harada, N Ogura, Y Akutsu, S Motohashi, T Iizasa, H Endo, T Fujisawa, H Shinkai, M Taniguchi

    CANCER RESEARCH   59 ( 20 )   5102 - 5105   1999.10

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  • A novel recognition motif of human NKT antigen receptor for a glycolipid ligand Reviewed

    T Kawano, Y Tanaka, E Shimizu, Y Kaneko, N Kamata, H Sato, H Osada, S Sekiya, T Nakayama, M Taniguchi

    INTERNATIONAL IMMUNOLOGY   11 ( 6 )   881 - 887   1999.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/intimm/11.6.881

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  • Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated V alpha 14 NKT cells Reviewed

    T Kawano, JQ Cui, Y Koezuka, Toura, I, Y Kaneko, H Sato, E Kondo, M Harada, H Koseki, T Nakayama, Y Tanaka, M Taniguchi

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   95 ( 10 )   5690 - 5693   1998.5

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    DOI： 10.1073/pnas.95.10.5690

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  • Requirement for V(α)14 NKT cells in IL-12-mediated rejection of tumors Reviewed

    Junqing Cui, Tahiro Shin, Tetsu Kawano, Hiroshi Sato, Eisuke Kondo, Isao Toura, Yoshikatsu Kaneko, Haruhiko Koseki, Masamoto Kanno, Masaru Taniguchi

    Science   278 ( 5343 )   1623 - 1626   1997.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1126/science.278.5343.1623

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  • CD1d-restricted and TCR-mediated activation of V(alpha)14 NKT cells by glycosylceramides Reviewed

    T Kawano, JQ Cui, Y Koezuka, Toura, I, Y Kaneko, K Motoki, H Ueno, R Nakagawa, H Sato, E Kondo, H Koseki, M Taniguchi

    SCIENCE   278 ( 5343 )   1626 - 1629   1997.11

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    DOI： 10.1126/science.278.5343.1626

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  • Shared T-Cell Receptor Repertoire in the Tonsils of Patients with Immunoglobulin A Nephropathy

    Kazunori Satokata, Shin Goto, Hiroki Yamaguchi, Hirofumi Watanabe, Nao Takahashi, Koichi Higashi, Suguru Yamamoto, Yoshikatsu Kaneko, Arata Horii, Ken Kurokawa, Ichiei Narita

    Kidney360   2026.2

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    Publishing type：Research paper (scientific journal)   Publisher：Ovid Technologies (Wolters Kluwer Health)  

    Background:

    Aberrant mucosal immune responses are underlying causes of Immunoglobulin A nephropathy (IgAN), the most prevalent type of chronic glomerulonephritis. However, the role of T cells in IgAN pathogenesis remains elusive. To address this knowledge gap, we profiled the T-cell receptor (TCR) repertoire in the tonsils of patients with IgAN.

    Methods:

    This study included 27 and 20 patients with biopsy-confirmed IgAN and recurrent tonsillitis (RT), respectively, who underwent tonsillectomy. The TCR repertoire was determined by high-throughput sequencing coupled with unbiased adaptor ligation polymerase chain reaction (PCR). Furthermore, the usage of variable and joining regions in TCRα (TRA) and β (TRB) genes in each group was assessed. TRA clonotypes shared among the patients were characterized by complementary determining region 3 (CDR3) lengths, types of mucosal-associated invariant T (MAIT) cells, hydrophobicity, and their relationships with tonsillar galactose-deficient IgA1 (Gd-IgA1) and tonsillar IgA-binding indices of tonsillar bacteria.

    Results:

    The TRA repertoire exhibited significantly lower similarity in patients with IgAN than did in RT cases ( P < 0.001). Sharing TRA clonotypes among patients with IgAN was significantly sparser than that among RT cases. The relative abundance of shared TRA clonotypes with shorter CDR3 lengths was significantly increased in patients with IgAN ( P_adj = 0.041), which was characterized by low MAIT match scores. Significant negative correlations were observed between the MAIT scores and hydrophobicity for these TRA clonotypes in patients with IgAN. The relative abundances of these clonotypes significantly and positively correlated with the IgA binding indices of the phylum Bacteroidetes ( P_adj = 0.008) in both groups and tonsillar Gd-IgA1 levels in patients with IgAN ( P = 0.035).

    Conclusions:

    The results in this study suggest aberrant T-cell subsets involvement in tonsillar immunity in patients with IgAN.

    DOI： 10.34067/kid.0000001154

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  • Oral iptacopan therapy in patients with C3 glomerulopathy: a randomised, double-blind, parallel group, multicentre, placebo-controlled, phase 3 study

    David Kavanagh, Andrew S Bomback, Marina Vivarelli, Carla M Nester, Giuseppe Remuzzi, Ming-Hui Zhao, Edwin K S Wong, Yaqin Wang, Induja Krishnan, Imelda Schuhmann, Angelo J Trapani, Nicholas J A Webb, Matthias Meier, Rubeen K Israni, Richard J H Smith, Alejandra Ines Espinosa, Rita Marcela Fortunato, Magali Freijo Freijo, Nadia Fretes, Pablo Miguel Raffaele, Gianna Mastroianni Kirsztajn, Juliana Mansur Siliano, Laila Almeida Viana, Dervla Connaughton, Susan Huang, Faisal Rehman, Pavel Roshanav, Matthew A. Weir, Dong-Yuan Chang, Pei Chen, Bixia Gao, Ying Tan, Li Yang, Xiao-Juan Yu, Xin Zhang, Ming-Hui Zhao, Chuan-Ming Hao, Ling-Yun Lai, Shao-Jun Liu, Eva Jancova, Vladimir Tesar, Anne Blanchard, Sophie Chauvet, Nathalie Chavarot, Roxane Gaisset, François Provôt, Myriam Dao, Hamza Sakhi, Aude Servais, Julia Weinmann-Menke, Ute Eisenberger, Anja Gäckler, Benjamin Wilde, Anne Dieterle, Michael Wiesener, Tobias Huber, Malte Andreas Kluger, Eleftheria-Kleio Dermitzaki, Charikleia Gakiopoulou, Konstantinos Stylianou, Narayan Prasad, Dharmendra Singh Bhadauria, Dinesh Khullar, Soumita Bagchi, Naomi Ben-Dor, Valeria Morduhovich, Benaya Rozen-Zvi, Yael Borovitz, Daniel Landau, Camillo Carrara, Erica Daina, Amantia Imeraj, Maddalena Marasà, Piero Luigi Ruggenenti, Giuseppe Remuzzi, Luca Antonucci, Marcello Chinali, Antonio Gargiulo, Marina Vivarelli, Federica Zotta, Sosuke Fukui, Hangsoo Kim, Masashi Mizuno, Yasuhiro Suzuki, Shin Goto, Michihiro Hosojima, Hideyuki Kabasawa, Yoshikatsu Kaneko, Ryohie Kaseda, Ichiei Narita Narita, Tadashi Otsuka, Hirofumi Watanabe, Suguru Yamamoto, Motoki Matsuki, Naoki Nagakawa, Wataru Ohwada, Arata Osanami, Hidemichi Kouzu, Tomohisa Yamashita, Toshiyuki Yano, Hanneke Bouwsma, Aiko Popke Jan de Vries, Soufiane Meziyerh, Wouter Moest, Dennis A.J. Van den Broek, Y.K. Onno Teng, Teresa Cavero Escribano, Wenceslao Adrian Aguilera Morales, Francisco Jose de la Prada Alvarez, Fabiola Alonso Garcia, Mercedes Salgueira Lazo, Katarina Benackova, Uyen Huynh-Do, Laila-Yasmin Mani, Sibylle Tschumi, Asil Demirezen, Özant Helvaci, Betul Ogut, Saliha Yildirim, David Kavanagh, Edwin K.S. Wong, Tom Cairns, Stephen Paul McAdoo, Liz Lightstone, Nicholas Medjeral-Thomas, Matthew Pickering, Wooin Ahn, Gerald B. Appel, Andrew S. Bomback, Pietro Canetta, Elizabeth Hendren, Allyson Medina, Mariela Navarro-Torress, Jai Radhakrishnan, Jennifer Jetton, Christina Michels, Carla M. Nester, Richard J.H. Smith, James Alan Tumlin

    The Lancet   406 ( 10512 )   1587 - 1598   2025.10

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/s0140-6736(25)01148-1

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  • Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1 Promotes the Progression of Renal Fibrosis Mediated by Versican 1 in Mouse Remnant Kidney. International journal

    Yoshikatsu Kaneko, Yuya Suzuki, Kaho Sato, Kosei Takeuchi, Michihiro Igarashi, Ichiei Narita

    Nephrology (Carlton, Vic.)   30 ( 8 )   e70109   2025.8

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    AIM: Renal fibrosis is a final common pathway for progressive chronic kidney diseases. Immune cell infiltration and production of tumour growth factor-β (TGF-β) are essential factors for fibrosis development. We examined the role of chondroitin sulfate (CS) proteoglycan, which is one of the main extracellular matrix components induced by TGF-β signalling. We also examined CS N-acetylgalactosaminyltransferase 1 (T1), an enzyme that catalyses the first step of CS-specific synthesis. METHODS: T1-/- mice, genetically lacking T1, and T1+/+ mice underwent 5/6 nephrectomy (Nx) or sham operation. Kidney function, urine marker, mRNA expression, and TGF-β signalling were evaluated 1 month after Nx or sham operation. Renal fibrotic area was quantified 3 months later. RESULTS: Both T1+/+ and T1-/- mice with Nx showed equivalent loss of kidney function; however, a tubular damage marker, upregulation of TGF-β and collagen expression, and renal fibrosis were suppressed in T1-/- mice with Nx. Versican, one of the core proteins of CS proteoglycan, was exclusively upregulated in T1+/+ mice with Nx. Among the versican splicing variants, versican 1 (V1) was expressed in the medullary interstitium of the remnant kidney in T1+/+ mice. V1 was produced in the interstitial macrophages, fibroblasts/myofibroblasts, and endothelial cells, whereas TGF-β was expressed in fibroblasts/myofibroblasts. Phosphorylation of the TGF-β signalling molecules Smad2/3 was not induced in T1-/- mice with Nx. In vivo administration of TGF-β inhibitor into Nx mice reduced V1 and Tgfb expression. CONCLUSION: T1 was essential for effective TGF-β signalling, V1 upregulation, and subsequent renal fibrosis.

    DOI： 10.1111/nep.70109

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  • 常染色体顕性Alport症候群と遺伝性心筋緻密化障害の合併例の遺伝子解析による原因変異の同定

    相田 涼, 渡辺 博文, 椎谷 貴光, 大塚 忠司, 忰田 亮平, 金子 佳賢, 後藤 眞, 山本 卓

    日本腎臓学会誌   67 ( 4 )   510 - 510   2025.6

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    Language：Japanese   Publisher：(一社)日本腎臓学会  

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  • 長期レニン-アンジオテンシン系阻害による腎輸入細動脈肥厚と腎障害に対するネプリライシン阻害の保護効果

    椎谷 貴光, 渡辺 博文, 相田 涼, 大塚 忠司, 忰田 亮平, 金子 佳賢, 後藤 眞, 山本 卓

    日本腎臓学会誌   67 ( 4 )   489 - 489   2025.6

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  • 近位尿細管特異的蛋白ACSM2の急性腎障害回復過程における機能

    渡辺 博文, 椎谷 貴光, 相田 涼, 大塚 忠司, 忰田 亮平, 金子 佳賢, 後藤 眞, 山本 卓

    日本腎臓学会誌   67 ( 4 )   498 - 498   2025.6

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  • Genetic and protein structure prediction analyses identify a rare pathogenic PKD1 variant causing autosomal dominant polycystic kidney disease.

    Takamitsu Shiiya, Hirofumi Watanabe, Ryo Aida, Tadashi Otsuka, Ryohei Kaseda, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Ichiei Narita

    CEN case reports   2025.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenic kidney disorders. The diagnosis of ADPKD requires imaging findings showing multiple kidney cysts or genetic testing, in cases where a family history is unknown. We report a patient diagnosed with ADPKD based on the identification of a rare PKD1 variant. The patient was a 41-year-old female in whom cysts and calcification in the kidneys were incidentally detected. Whole-exome sequencing identified a rare PKD1 variant (NM_001009944.3: c.11557G > A/p.E3853K). Protein structure prediction of the PKD1-PKD2 complex showed that the variant may be pathogenic, leading to the diagnosis of autosomal dominant polycystic kidney disease. A detailed family history revealed that her relatives also had ADPKD, further supporting the diagnosis of ADPKD. Comprehensive genetic analysis and protein structure prediction led to the diagnosis of ADPKD and the identification of rare causative genes. These methods are useful for diagnosing hereditary kidney diseases of unknown etiologies.

    DOI： 10.1007/s13730-025-00985-4

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  • Nephrotic syndrome induces the upregulation of cell proliferation-related genes in tubular cells in mice

    Yuya Suzuki, Ryohei Kaseda, Yusuke Nakagawa, Hirofumi Watanabe, Tadashi Otsuka, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Taiji Matsusaka, Ichiei Narita

    Clinical and Experimental Nephrology   2024.12

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Background

    Massive proteinuria, dyslipidemia, and hypoalbuminemia induced by nephrotic syndrome (NS) secondarily affect tubular cells. We conducted an RNA sequencing (RNA-seq) analysis using a mouse model of focal segmental glomerulosclerosis to clarify the impact of NS on tubular cells.

    Methods

    We used transgenic mice expressing hCD25 in podocytes (Nep25) to induce NS by injecting human CD25-specific immunotoxin (LMB2) at a dose of 0.625 ng/g body weight. Seven days after LMB2 injection, we extracted RNA from the whole kidney and conducted an RNA-seq analysis. Subsequently, we conducted multiple immunostaining and in situ hybridization (ISH) of differentially expressed genes (DEGs) to identify their locations and associated cell types. We also investigated the expression levels of DEGs in an additional mouse model of NS induced by adriamycin.

    Results

    After NS induction, 562 upregulated and 430 downregulated DEGs were identified using RNA-seq. An enrichment analysis revealed the upregulation of cell proliferation-related genes. We observed significant upregulation of Foxm1, a transcription factor linked to cell proliferation. Immunostaining and ISH showed that various tubular cells expressed Mki67 and Foxm1 during NS development. The adriamycin-induced NS model also demonstrated the upregulation of Mki67 and Foxm1 in tubular cells.

    Conclusions

    NS induced the upregulation of cell proliferation-related genes in tubular cells without detectable renal dysfunction. Our findings may contribute to understanding the pathological effects of nephrotic syndrome on tubular cells.

    DOI： 10.1007/s10157-024-02608-1

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  • CD38 ligation in sepsis promotes nicotinamide phosphoribosyltransferase-mediated IL-6 production in kidney stromal cells. International journal

    Yuya Suzuki, Tadashi Otsuka, Yusuke Takahashi, Shingo Maruyama, Alexey Annenkov, Yasuhiro Kanda, Tomoya Katakai, Hirofumi Watanabe, Riuko Ohashi, Yoshikatsu Kaneko, Ichiei Narita

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   2024.11

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    BACKGROUND AND HYPOTHESIS: Activated macrophages, pivotal for driving the immune response in sepsis, express high levels of CD38. Although the circulating levels of its ligand, CD31, increase in sepsis, the functions of CD38 and its ligation remain elusive. This study aimed to elucidate the impact of CD38 ligation on sepsis using single-cell and single-nucleus RNA sequencing (scRNA-seq and snRNA-seq, respectively) to identify a novel therapeutic target for severe sepsis. METHODS: We performed scRNA-seq analysis of mouse peritoneal immune cells to precisely identify cell types exhibiting increased CD38 expression upon exposure to lipopolysaccharide (LPS). Subsequently, we induced CD38 ligation using a well-established agonistic anti-CD38 antibody in a mouse model of LPS-induced sepsis. We analyzed its pathophysiological effects using kidney snRNA-seq. Finally, we performed histological analysis of septic tissues collected from patients to ensure consistency of our findings between mice and humans. RESULTS: LPS stimulation upregulated CD38 expression in peritoneal macrophages. CD38 ligation significantly exacerbated LPS-induced inflammation in vivo, particularly in the kidneys. Kidney snRNA-seq analysis revealed that CD38 ligation induced interleukin (IL)-6 production in renal stromal cells via nicotinamide phosphoribosyltransferase (NAMPT) signaling originating from CD38-positive macrophages. NAMPT inhibition significantly ameliorated LPS-induced IL-6 production and kidney injury. Histological analysis of human septic tissues demonstrated upregulation of IL6 mRNA and NAMPT in renal stromal cells and CD38-positive macrophages, respectively. CONCLUSION: Our findings elucidate the implications of CD38 ligation in an LPS-induced sepsis model and uncover shared signaling pathways between mice and human sepsis. NAMPT signaling identified in this study may be a novel therapeutic target for mitigating systemic inflammation and kidney injury associated with severe sepsis.

    DOI： 10.1093/ndt/gfae269

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  • 網羅的遺伝子解析と蛋白構造予測で病原PKD1バリアントを同定し常染色体顕性(優性)多発性嚢胞腎と診断した一例

    椎谷 貴光, 渡辺 博文, 相田 涼, 大塚 忠司, 忰田 亮平, 山本 卓, 金子 佳賢, 後藤 眞

    日本腎臓学会誌   66 ( 6-E )   899 - 899   2024.9

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  • 網羅的遺伝子解析と蛋白構造予測で病原PKD1バリアントを同定し常染色体顕性(優性)多発性嚢胞腎と診断した一例

    椎谷 貴光, 渡辺 博文, 相田 涼, 大塚 忠司, 忰田 亮平, 山本 卓, 金子 佳賢, 後藤 眞

    日本腎臓学会誌   66 ( 6-E )   899 - 899   2024.9

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  • Pathogenetic associations of anti-ribosomal P protein antibody titres and its subclasses in patients with systemic lupus erythematosus

    Yoshikatsu Kaneko, Hiroe Sato, Ayako Wakamatsu, Daisuke Kobayashi, Kaho Sato, Yoichi Kurosawa, Eriko Hasegawa, Takeshi Nakatsue, Takeshi Kuroda, Ichiei Narita

    Rheumatology   2023.8

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    Abstract

    Objectives

    We evaluated the association between anti-ribosomal P antibody (anti-RibP) titres and disease activity in Japanese systemic lupus erythematosus (SLE) patients.

    Methods

    Eighty patients admitted and treated in Niigata University Hospital for new-onset or flare-up of SLE were included in this retrospective cross-sectional study. Clinical data were obtained from medical records at admission. Anti-RibP index, and cytokine and tryptophan metabolite levels were determined by ELISA.

    Results

    Of the 80 SLE patients, 30 had anti-RibP. Anti-RibP presence was associated with a greater prevalence of skin rash and more severe inflammatory responses, demonstrated by higher inflammatory cytokine levels, hypocomplementemia, and accelerated tryptophan metabolism, in younger patients. The serum anti-RibP index correlated with age at diagnosis, clinical indicators, initial prednisolone dose, and cytokines and tryptophan metabolite levels in univariate analysis. Multivariate analysis showed the anti-RibP index was independently associated with initial prednisolone dose and prevalence of skin rash. Anti-RibP IgG were mainly IgG2 and IgG3 subclasses, and anti-RibP IgG3 was associated with hypocomplementemia, higher disease activity score, accelerated kynurenine pathway activity, and higher proinflammatory cytokine production. The coexistence of anti-dsDNA IgG and anti-RibP IgG2 or IgG3 accompanied higher IL-10 and IFN-α2 levels; furthermore, anti-RibP IgG3 coexistence with anti-dsDNA antibody contributed to the requirement for higher initial prednisolone doses and accelerated kynurenine pathway activity.

    Conclusion

    Anti-RibP was associated with clinical manifestations and parameters in SLE, and its index might be a useful indicator of disease severity. Anti-RibP IgG3 was the IgG subclass most strongly associated with the pathogenesis of SLE.

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  • Sodium magnetic resonance imaging shows impairment of the counter-current multiplication system in diabetic mice kidney. International journal

    Yusuke Nakagawa, Ryohei Kaseda, Yuya Suzuki, Hirofumi Watanabe, Tadashi Otsuka, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Yasuhiko Terada, Tomoyuki Haishi, Susumu Sasaki, Ichiei Narita

    Kidney360   4 ( 5 )   582 - 590   2023.3

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    Sodium magnetic resonance imaging can non-invasively assess sodium distribution, specifically sodium concentration in the countercurrent multiplication system in the kidney, which forms a sodium concentration gradient from the cortex to the medulla, enabling efficient water reabsorption. This study aimed to investigate whether sodium magnetic resonance imaging can detect changes in sodium concentrations under normal conditions in mice and in disease models such as a mouse model with diabetes mellitus. Methods: We performed sodium and proton nuclear magnetic resonance imaging using a 9.4-T vertical standard-bore super-conducting magnet. Results: A condition of deep anesthesia, with widened breath intervals, or furosemide administration in 6-week-old C57BL/6JJcl mice showed a decrease in both tissue sodium concentrations in the medulla and sodium concentration gradients from the cortex to the medulla. Further, sodium magnetic resonance imaging revealed reductions in the sodium concentration of the medulla and in the gradient from the cortex to the medulla in BKS.Cg-Leprdb+/+ Leprdb/Jcl mice at very early type-2 diabetes mellitus stages compared to corresponding control BKS.Cg-m+/m+/Jcl mice. Conclusions: The kidneys of BKS.Cg-Leprdb+/+ Leprdb/Jcl mice aged 6 weeks showed impairments in the countercurrent multiplication system. We propose the utility of 23Na MRI for evaluating functional changes in diabetic kidney disease, not as markers that reflect structural damage. Thus, 23Na MRI may be a potential very early marker for structures beyond the glomerulus; this may prompt intervention with novel efficacious tubule-targeting therapies.

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  • Assessing fluid volume and determining outcomes of acute heart failure using plasma human atrial natriuretic peptide.

    Yuya Suzuki, Tadashi Otsuka, Yuki Yoshioka, Tomomichi Iida, Shingo Maruyama, Hirofumi Watanabe, Ryohei Kaseda, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Ryuji Aoyagi, Ichiei Narita

    Clinical and experimental nephrology   27 ( 6 )   565 - 573   2023.3

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    BACKGROUND: The post-dialysis plasma level of human atrial natriuretic peptide (hANP) reflects the fluid volume in patients on hemodialysis. The threshold hANP level is reportedly 100 pg/mL; however, the clinical usefulness of the threshold hANP level for volume control has not been sufficiently studied. METHODS: We conducted a single-center, retrospective, observational study that included 156 hemodialysis patients without atrial fibrillation. First, we examined the usefulness of the threshold hANP level (100 pg/mL) for predicting hypoxemia due to congestion in a short-term observational study from December 30, 2015 to January 5, 2016. Subsequently, we conducted a 5-year follow-up study wherein the outcomes were hospitalization due to acute heart failure (AHF), development of cardiovascular diseases (CVD), and all-cause death. Finally, we collected echocardiography data to investigate the relationship between cardiac function and hANP. RESULTS: Our short-term observational study showed that patients with an hANP level ≥ 100 pg/mL developed hypoxemia due to congestion (odds ratio, 3.52; 95% confidence interval, 1.06-11.71; P = 0.040). At the 5-year follow-up, patients with an hANP level ≥ 100 pg/mL had significantly higher rates of hospitalization due to AHF, CVD, and all-cause death based on the log-rank test (P = 0.003, P = 0.019, P < 0.001, respectively). Cardiac disfunctions were significantly associated with the high hANP level. CONCLUSIONS: The hANP level is indicative of both fluid volume and cardiac dysfunction. A threshold hANP level of 100 pg/mL can serve as a predictive marker for AHF and a practical indicator for volume control.

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  • IgA腎症患者の扁桃陰窩におけるT細胞受容体publicレパトアの解析

    里方 一紀, 後藤 眞, 渡辺 博文, 山口 浩毅, 土田 雅史, 米澤 正貴, 山本 卓, 金子 佳賢, 成田 一衛

    日本腎臓学会誌   64 ( 3 )   219 - 219   2022.5

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  • A digest from evidence-based Clinical Practice Guideline for Polycystic Kidney Disease 2020.

    Saori Nishio, Ken Tsuchiya, Shinya Nakatani, Satoru Muto, Toshio Mochizuki, Haruna Kawano, Kazushige Hanaoka, Sumi Hidaka, Daisuke Ichikawa, Eiji Ishikawa, Kiyotaka Uchiyama, Eri Koshi-Ito, Hiroki Hayashi, Shiho Makabe, Soshiro Ogata, Michihiro Mitobe, Akinari Sekine, Tatsuya Suwabe, Hiroshi Kataoka, Hirayasu Kai, Yoshikatsu Kaneko, Mahiro Kurashige, Koichi Seta, Keiji Shimazu, Taketsugu Hama, Kenichiro Miura, Koichi Nakanishi, Shigeo Horie, Kengo Furuichi, Hirokazu Okada, Ichiei Narita

    Clinical and experimental nephrology   25 ( 12 )   1292 - 1302   2021.9

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    DOI： 10.1007/s10157-021-02097-6

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  • 糸球体結節性病変と係蹄壁へのIgG線状沈着を呈した境界型糖尿病の1例

    山口 浩毅, 細島 康宏, 蒲澤 秀門, 後藤 佐和子, 後藤 慧, 伊藤 由美, 今井 直史, 金子 佳賢, 鈴木 芳樹, 齋藤 亮彦, 成田 一衛

    糖尿病   64 ( 7 )   411 - 411   2021.7

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  • 糸球体結節性病変と係蹄壁へのIgG線状沈着を呈した境界型糖尿病の1例

    山口 浩毅, 細島 康宏, 蒲澤 秀門, 後藤 佐和子, 後藤 慧, 伊藤 由美, 今井 直史, 金子 佳賢, 鈴木 芳樹, 齋藤 亮彦, 成田 一衛

    糖尿病   64 ( 7 )   411 - 411   2021.7

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  • IgA腎症患者の扁桃陰窩におけるT嚢胞受容体レパトア解析

    里方 一紀, 後藤 眞, 渡辺 博文, 山口 浩毅, 土田 雅史, 米澤 正貴, 山本 卓, 金子 佳賢, 成田 一衛

    日本腎臓学会誌   63 ( 4 )   422 - 422   2021.6

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  • 膜性腎症における抗リボソームP抗体の関与

    佐藤 弘恵, 金子 佳賢, 若松 彩子, 伊藤 由美, 黒澤 陽一, 長谷川 絵理子, 小林 大介, 中枝 武司, 成田 一衛

    日本腎臓学会誌   63 ( 4 )   497 - 497   2021.6

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  • IgA腎症患者の扁桃陰窩におけるT細胞受容体レパトア解析

    里方 一紀, 後藤 眞, 渡辺 博文, 山口 浩毅, 土田 雅史, 米澤 正貴, 山本 卓, 金子 佳賢, 成田 一衛

    日本腎臓学会誌   63 ( 4 )   422 - 422   2021.6

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  • 日本腎臓学会でのバーチャルスライド登録とその展望

    忰田 亮平, 大塚 忠司, 金子 佳賢, 杉山 斉, 清水 章, 横山 仁, 佐藤 博, 成田 一衛

    腎臓内科   13 ( 4 )   534 - 541   2021.4

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  • Association of coexisting anti-ribosomal P and anti-dsDNA antibodies with histology and renal prognosis in lupus nephritis patients Reviewed International journal

    Ayako Wakamatsu, Hiroe Sato, Yoshikatsu Kaneko, Takamasa Cho, Yumi Ito, Yoichi Kurosawa, Eriko Hasegawa, Daisuke Kobayashi, Takeshi Nakatsue, Takeshi Kuroda, Yoshiki Suzuki, Toshio Uchiumi, Ichiei Narita

    Lupus   30 ( 3 )   096120332098390 - 096120332098390   2021.1

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    <sec><title>Objectives</title> Anti-ribosomal P protein autoantibodies (anti-P) specifically develop in patients with systemic lupus erythematosus. Associations of anti-P with lupus nephritis (LN) histological subclass and renal outcome remain inconclusive. We sought to determine the association of anti-P and anti-double-stranded DNA antibody (anti-dsDNA) with renal histology and prognosis in LN patients.

    </sec><sec><title>Methods</title> Thirty-four patients with LN, having undergone kidney biopsy, were included. The 2018 revised ISN/RPS classification system was used for pathophysiological evaluation. Chronic kidney disease (CKD) was defined as an estimated glomerular filtration rate &lt; 60 mL/min/1.73 m<sup>2</sup> for &gt; 3 months.

    </sec><sec><title>Results</title> Six patients (17.6%) were positive for anti-P and 26 (76.5%) for anti-dsDNA. Among the six patients with anti-P, one did not have anti-dsDNA, but did have anti-Sm antibody, and showed a histological subtype of class V. This patient maintained good renal function for over 14 years. The remaining five patients, who had both anti-P and anti-dsDNA, exhibited proliferative nephritis and were associated with prolonged hypocomplementemia, and the incidence of CKD did not differ from patients without anti-P.

    </sec><sec><title>Conclusion</title> Although this study included a small number of patients, the results indicated that histology class and renal prognosis associated with anti-P depend on the coexistence of anti-dsDNA. Further studies with a large number of patients are required to confirm this conclusion.

    </sec>

    DOI： 10.1177/0961203320983906

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  • Erratum to: Aberrant mucosal immunoreaction to tonsillar microbiota in immunoglobulin A nephropathy. International journal

    Hiroki Yamaguchi, Shin Goto, Nao Takahashi, Masafumi Tsuchida, Hirofumi Watanabe, Suguru Yamamoto, Yoshikatsu Kaneko, Koichi Higashi, Hiroshi Mori, Yukio Nakamura, Arata Horii, Ken Kurokawa, Ichiei Narita

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   2021.1

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    DOI： 10.1093/ndt/gfaa319

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  • Aberrant mucosal immunoreaction to tonsillar microbiota in immunoglobulin A nephropathy Reviewed International journal

    Hiroki Yamaguchi, Shin Goto, Nao Takahashi, Masafumi Tsuchida, Hirofumi Watanabe, Suguru Yamamoto, Yoshikatsu Kaneko, Koichi Higashi, Hiroshi Mori, Yukio Nakamura, Arata Horii, Ken Kurokawa, Ichiei Narita

    Nephrology Dialysis Transplantation   36 ( 1 )   75 - 86   2021.1

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    <title>Abstract</title>
    <sec>
    <title>Background</title>
    Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis worldwide, characterized by mesangial polymeric IgA1 deposition. IgAN is believed to develop owing to aberrant mucosal immunoreaction against commensals in the tonsils. However, the exact interrelation between pathogenic IgA and mucosal microbiota in IgAN patients is unclear.


    </sec>
    <sec>
    <title>Methods</title>
    Biopsy-proven IgAN or recurrent tonsillitis (RT) patients who had undergone tonsillectomy were enrolled. We used 16S ribosomal RNA gene amplicon sequencing with a flow cytometry-based bacterial cell sorting technique) and immunoglobulin repertoire sequencing of the IgA heavy chain to characterize IgA-coated bacteria of the tonsillar microbiota (IgA-SEQ) and their corresponding IgA repertoire. Furthermore, we fractionated patient serum using gel-filtration chromatography and performed flow cytometry-based analysis of IgA binding to bacteria cultured from incised tonsils.


    </sec>
    <sec>
    <title>Results</title>
    Tonsillar proliferation-inducing ligand and B-cell activating factor levels were significantly higher in IgAN than in RT patients. IgA-SEQ for tonsillar microbiota revealed the preferential binding ability of IgA to Bacteroidetes in IgAN tonsils compared with those from RT patients. Expression of immunoglobulin heavy (IGH) constant alpha 1 with IGH variable 3–30 was significantly higher in IgAN than that in RT, and positively correlated with the IgA-coated enrichment score of Bacteroidetes. Serum polymeric IgA, comprising high levels of GdIgA1, exhibited considerable binding to Bacteroidetes strains cultured from the tonsils of IgAN patients.


    </sec>
    <sec>
    <title>Conclusions</title>
    These findings provide evidence that aberrant mucosal immune responses to tonsillar anaerobic microbiota, primarily consisting of members of the phylum Bacteroidetes, are involved in IgAN pathophysiology.


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    DOI： 10.1093/ndt/gfaa223

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  • 【腎疾患領域における難病対策】わが国の難治性腎障害に関する調査研究班の取り組み

    成田 一衛, 忰田 亮平, 大塚 忠司, 金子 佳賢

    腎臓内科   13 ( 1 )   12 - 16   2021.1

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  • IgA腎症患者の扁桃陰窩におけるIgAレパトアとIgA結合細菌叢の関連

    山口 浩毅, 後藤 眞, 山本 卓, 金子 佳賢, 成田 一衛

    日本腎臓学会誌   62 ( 4 )   256 - 256   2020.7

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  • IgA腎症患者の扁桃陰窩におけるIgAレパトアとIgA結合細菌叢の関連

    山口 浩毅, 後藤 眞, 山本 卓, 金子 佳賢, 成田 一衛

    日本腎臓学会誌   62 ( 4 )   2020.7

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  • 抗リボソームP抗体とループス腎炎の長期腎予後との関連について

    佐藤 弘恵, 若松 彩子, 張 高正, 須藤 真則, 長谷川 絵理子, 細島 康宏, 小林 大介, 中枝 武司, 金子 佳賢, 成田 一衛

    日本腎臓学会誌   62 ( 4 )   268 - 268   2020.7

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  • Inorganic polyphosphate potentiates lipopolysaccharide-induced macrophage inflammatory response. Reviewed International journal

    Toru Ito, Suguru Yamamoto, Keiichi Yamaguchi, Mami Sato, Yoshikatsu Kaneko, Shin Goto, Yuji Goto, Ichiei Narita

    The Journal of biological chemistry   295 ( 12 )   4014 - 4023   2020.3

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    Inorganic polyphosphate (polyP) is a linear polymer of orthophosphate units that are linked by phosphoanhydride bonds and is involved in various pathophysiological processes. However, the role of polyP in immune cell dysfunction is not well-understood. In this study, using several biochemical and cell biology approaches, including cytokine assays, immunofluorescence microscopy, receptor-binding assays with quartz crystal microbalance, and dynamic light scanning, we investigated the effect of polyP on in vitro lipopolysaccharide (LPS)-induced macrophage inflammatory response. PolyP up-regulated LPS-induced production of the inflammatory cytokines, such as tumor necrosis factor α, interleukin-1β, and interleukin-6, in macrophages, and the effect was polyP dose- and chain length-dependent. However, orthophosphate did not exhibit this effect. PolyP enhanced the LPS-induced intracellular macrophage inflammatory signals. Affinity analysis revealed that polyP interacts with LPS, inducing formation of small micelles, and the polyP-LPS complex enhanced the binding affinity of LPS to Toll-like receptor 4 (TLR4) on macrophages. These results suggest that inorganic polyP plays a critical role in promoting inflammatory response by enhancing the interaction between LPS and TLR4 in macrophages.

    DOI： 10.1074/jbc.RA119.011763

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  • 腎移植後に腹膜透析を再導入した一例

    山崎 翔子, 飯田 倫理, 蒲澤 秀門, 忰田 亮平, 山本 卓, 金子 佳賢, 成田 一衛

    日本腎臓学会誌   61 ( 6 )   759 - 759   2019.8

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  • 腎移植後長期生着例2例を含む、WT1遺伝子変異によるFSGSの1家系

    酒巻 裕一, 後藤 眞, 今井 直史, 伊藤 由美, 山本 卓, 金子 佳賢, 田崎 正行, 齋藤 和英, 高橋 公太, 成田 一衛

    日本腎臓学会誌   61 ( 6 )   708 - 708   2019.8

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  • IgA腎症患者の口蓋扁桃陰窩におけるIgA結合細菌群と糖鎖不全IgA1

    山口 浩毅, 後藤 眞, 山本 卓, 金子 佳賢, 成田 一衛

    日本腎臓学会誌   61 ( 3 )   287 - 287   2019.5

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  • ポリリン酸はマクロファージのLPSに対する炎症反応を増幅する

    伊藤 徹, 山本 卓, 金子 佳賢, 後藤 眞, 下條 文武, 成田 一衛

    日本腎臓学会誌   61 ( 3 )   326 - 326   2019.5

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  • Successful treatment of gamma 1 heavy chain deposition disease with bortezomib and dexamethasone

    Masanori Sudo, Takuya Wakamatsu, Tomomi Ishikawa, Masato Habuka, Michihiro Hosojima, Suguru Yamamoto, Yumi Ito, Naofumi Imai, Yoshikatsu Kaneko, Akira Shimizu, Ichiei Narita

    Human Pathology: Case Reports   15   99 - 104   2019.3

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    DOI： 10.1016/j.ehpc.2019.01.001

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  • Cryofibrinogen-associated glomerulonephritis diagnosed by mass spectrometry and immunoelectron microscopy

    Masanori Sudo, Yuichi Sakamaki, Michihiro Hosojima, Suguru Yamamoto, Yumi Ito, Naofumi Imai, Yoshikatsu Kaneko, Shin Goto, Chih Ping Li, Akira Shimizu, Ichiei Narita

    Human Pathology: Case Reports   15   83 - 87   2019.3

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    DOI： 10.1016/j.ehpc.2018.12.002

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  • 全身性自己免疫疾患 抗リボソームP抗体はTNF-α産生を介してFcγ受容体依存性多臓器不全を誘導する(Systemic autoimmune diseases-3 Anti-ribosomal P antibody induces Fcγ receptor-dependent multiple organ dysfunction through TNF-α production)

    Cho Takamasa, Sato Hiroe, Kaneko Yoshikatsu

    日本免疫学会総会・学術集会記録   47 ( Proceedings )   2 - P   2018.12

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  • SLEモデルマウスにおける抗リボソームP抗体による精神障害・腎障害・肝障害の解明

    張 高正, 佐藤 弘恵, 金子 佳賢, 成田 一衛

    新潟県医師会報   ( 824 )   11 - 12   2018.11

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  • 膜性腎症にMPO-ANCA陽性の半月体形成を伴う糸球体腎炎を合併した一例

    若松 拓也, 蒲澤 秀門, 忰田 亮平, 金子 佳賢, 伊藤 由美, 今井 直史, 成田 一衛

    日本腎臓学会誌   60 ( 6 )   875 - 875   2018.8

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  • 抗リボソームP抗体による腎障害とTNF-α阻害薬による治療効果

    張 高正, 佐藤 弘恵, 金子 佳賢, 成田 一衛

    日本腎臓学会誌   60 ( 3 )   433 - 433   2018.4

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  • 抗リボソームP抗体・抗dsDNA抗体とループス腎炎病理組織所見の関連について

    若松 彩子, 佐藤 弘恵, 張 高正, 黒澤 陽一, 野澤 由貴子, 中枝 武司, 和田 庸子, 今井 直史, 伊藤 由美, 金子 佳賢, 中野 正明, 成田 一衛

    日本腎臓学会誌   60 ( 3 )   439 - 439   2018.4

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  • Indoxyl sulfate promotes macrophage il-1β production by activating aryl hydrocarbon receptor/nf-κ/mapk cascades, but the nlrp3 inflammasome was not activated Reviewed

    Takuya Wakamatsu, Suguru Yamamoto, Toru Ito, Yoko Sato, Koji Matsuo, Yoshimitsu Takahashi, Yoshikatsu Kaneko, Shin Goto, Junichiro James Kazama, Fumitake Gejyo, Ichiei Narita

    Toxins   10 ( 3 )   2018.3

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    DOI： 10.3390/toxins10030124

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  • Adsorption of Protein-Bound Uremic Toxins Through Direct Hemoperfusion With Hexadecyl-Immobilized Cellulose Beads in Patients Undergoing Hemodialysis Reviewed

    Suguru Yamamoto, Mami Sato, Yoko Sato, Takuya Wakamatsu, Yoshimitsu Takahashi, Akira Iguchi, Kentaro Omori, Yasushi Suzuki, Isei Ei, Yoshikatsu Kaneko, Shin Goto, Junichiro J. Kazama, Fumitake Gejyo, Ichiei Narita

    Artificial Organs   42 ( 1 )   88 - 93   2018.1

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    DOI： 10.1111/aor.12961

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  • ヘキサデキル基固定セルロースビーズによる蛋白結合尿毒症物質の吸着効果

    山本 卓, 佐藤 茉美, 佐藤 容子, 若松 拓也, 高橋 良光, 井口 昭, 大森 健太郎, 鈴木 靖, 惠 以盛, 金子 佳賢, 後藤 眞, 風間 順一郎, 下條 文武, 成田 一衛

    日本透析医会雑誌   32 ( 3 )   516 - 519   2017.12

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  • 全身性自己免疫疾患(1) 抗リボソームタンパク質抗体は精神病および肝炎を誘発する(Systemic autoimmune disease(1) Anti-ribosomal-P antibody induces psychosis and hepatitis)

    Cho Takamasa, Kaneko Yoshikatsu, Sato Hiroe

    日本免疫学会総会・学術集会記録   46 ( Proceedings )   2 - O/P   2017.12

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  • ボルテゾミブが奏功した意義不明の単クローン性ガンマグロブリン血症(MGUS)に伴う重鎖沈着症(HCDD)の一例

    須藤 真則, 若松 拓也, 石川 友美, 羽深 将人, 細島 康宏, 山本 卓, 伊藤 由美, 今井 直史, 金子 佳賢, 瀧澤 淳, 成田 一衛

    日本腎臓学会誌   59 ( 6 )   869 - 869   2017.9

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  • 維持透析妊婦の周産期心筋症を来した一例

    宮崎 慧, 土田 雅史, 蒲澤 秀門, 保坂 聖子, 忰田 亮平, 金子 佳賢, 成田 一衛

    日本腎臓学会誌   59 ( 6 )   874 - 874   2017.9

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  • 腎臓病のゲノム研究

    成田 一衛, 後藤 眞, 金子 佳賢

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   6回   97 - 97   2017.5

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  • PAX2遺伝子変異患者におけるiPS細胞樹立と後腎ネフロン前駆細胞への分化に関する研究

    酒巻 裕一, 金子 佳賢, 成田 一衛

    日本透析医会雑誌   32 ( 1 )   180 - 184   2017.4

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  • Comparison of methods of steroid administration combined with tonsillectomy for IgA nephropathy patients Reviewed

    Hirofumi Watanabe, Shin Goto, Daisuke Kondo, Takuma Takata, Hajime Yamazaki, Michihiro Hosojima, Suguru Yamamoto, Yoshikatsu Kaneko, Ryuji Aoyagi, Ichiei Narita

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   21 ( 2 )   257 - 265   2017.4

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    DOI： 10.1007/s10157-016-1282-8

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  • インドキシル硫酸はマクロファージのAhR/NF-κB/MAPK系を活性化させる一方、NLRP3インフラマソーム活性を抑制する

    若松 拓也, 山本 卓, 松尾 浩司, 金子 佳賢, 後藤 眞, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   59 ( 3 )   283 - 283   2017.4

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  • レニン-アンギオテンシン系阻害は腎不全ラットの破骨細胞活性を抑制し、石灰化障害を改善させる

    佐藤 容子, 若松 拓也, 山本 卓, 伊藤 明美, 岩崎 香子, 金子 佳賢, 後藤 眞, 深川 雅史, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   59 ( 3 )   276 - 276   2017.4

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  • Hemodiafiltration for hepatic encephalopathy induced by Budd-Chiari syndrome in a patient with end-stage kidney disease. Reviewed

    Wakamatsu T, Yamamoto S, Kamimura K, Nakatsue T, Iino N, Iguchi S, Kaneko Y, Goto S, Kazama JJ, Narita I

    CEN case reports   5 ( 2 )   125 - 130   2016.11

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    DOI： 10.1007/s13730-015-0209-7

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  • 透析非導入に至った超高齢者慢性腎臓病患者の1例

    山本 卓, 吉澤 優太, 後藤 慧, 高井 千夏, 酒巻 裕一, 金子 佳賢, 後藤 眞, 風間 順一郎, 丸山 弘樹, 成田 一衛

    日本老年医学会雑誌   53 ( 4 )   447 - 448   2016.10

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  • Is IgA nephropathy (IgAN) a familial or sporadic disease? Reviewed

    Ichiei Narita, Yoshikatsu Kaneko, Yumi Itoh, Yuichi Sakamaki, Seitaro Iguchi, Suguru Yamamoto, Minako Wakasugi, Junichiro J. Kazama, Shin Goto

    Pathogenesis and Treatment in IgA Nephropathy: An International Comparison   43 - 51   2016.3

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    DOI： 10.1007/978-4-431-55588-9_3

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  • [112th Scientific Meeting of the Japanese Society of Internal Medicine: Educational Lecture: The Pathophysiology of IgA Nephropathy: Recent Advancement and Perspectives]. Reviewed

    Narita I, Goto S, Kaneko Y

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   104 ( 9 )   1930 - 1936   2015.9

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  • IgA腎症の病態解明 最近の進歩と課題

    成田 一衛, 後藤 眞, 金子 佳賢

    日本内科学会雑誌   104 ( 9 )   1930 - 1936   2015.9

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  • Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate Reviewed

    Koji Matsuo, Suguru Yamamoto, Takuya Wakamatsu, Yoshimitsu Takahashi, Kazuko Kawamura, Yoshikatsu Kaneko, Shin Goto, Junichiro J. Kazama, Ichiei Narita

    TOXINS   7 ( 8 )   3155 - 3166   2015.8

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    DOI： 10.3390/toxins7083155

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  • TAFRO症候群に合併した急性腎障害に対してCRRTを要した1例

    須藤 真則, 酒巻 裕一, 若松 彩子, 渡辺 博文, 蒲澤 秀門, 山本 卓, 金子 佳賢, 山崎 肇, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   57 ( 6 )   951 - 951   2015.8

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  • 経皮的腎動脈形成術により腎機能の著明な改善が得られた片側腎動脈狭窄の一例

    大塚 忠司, 酒巻 裕一, 山本 卓, 金子 佳賢, 伊藤 由美, 今井 直史, 成田 一衛, 猪俣 繁, 捧 博輝

    日本腎臓学会誌   56 ( 6 )   863 - 863   2014.8

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  • A case of membranoproliferative glomerulonephritis developed over twenty years with three different findings of renal pathology. Reviewed

    Kaneko Y, Yoshita K, Kabasawa H, Imai N, Ito Y, Ueno M, Nishi S, Narita I

    CEN case reports   2 ( 1 )   76 - 83   2013.5

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    A 31-year-old woman with proteinuria, hypocomplementemia, rheumatoid factor, and high serum polyclonal IgM concentration was admitted to our hospital for renal biopsy. She had a past history of two renal biopsies. When she was 12 years old, she developed proteinuria, microscopic hematuria, and hypocomplementemia. She was diagnosed as having 'IgM nephropathy' based on minor glomerular abnormalities as determined by light microscopy and IgM and C3 deposition in the mesangial region by immunofluorescence microscopy at the first biopsy. Despite corticosteroid treatment, her proteinuria did not improve and she discontinued regular outpatient checkups. When she was 29 years old and pregnant, she developed preeclampsia and, after delivery, a second renal biopsy was implemented. She was diagnosed as having progressed 'IgM nephropathy' with endotheliosis induced by preeclampsia. She was treated with angiotensin II receptor blocker and her proteinuria diminished; however, 1 year after the delivery, she developed proteinuria again, along with microscopic hematuria and hypocomplementemia. A third renal biopsy was conducted at 31 years of age and she was diagnosed as having membranoproliferative glomerulonephritis (MPGN) type I on the basis of diffuse mesangial proliferation, endocapillary hypercellularity with double contour of the capillary wall, and lobular formation in glomeruli, as determined by light microscopy. Immunofluorescence staining demonstrated deposits of C3, C4, C1q, and IgM in the mesangial region and capillary wall. She underwent corticosteroid therapy followed by normalization of urinalysis and serum complement level. Although she had initially been diagnosed with 'IgM nephropathy', she was finally diagnosed with secondary MPGN and was successfully treated by corticosteroid therapy.

    DOI： 10.1007/s13730-012-0042-1

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  • IgA腎症感受性の責任遺伝子

    成田 一衛, 後藤 眞, 金子 佳賢

    日本腎臓学会誌   55 ( 3 )   264 - 264   2013.4

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  • [Nephritis and nephrotic syndrome]. Reviewed

    Kaneko Y, Narita I

    Nihon Jinzo Gakkai shi   55 ( 1 )   35 - 41   2013

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  • 肉眼的血尿が持続し急速に腎機能が低下したIgA腎症の一例

    蒲澤 秀門, 笹川 泰司, 金子 佳賢, 後藤 眞, 河野 恵美子, 吉田 一浩, 伊藤 由美, 今井 直史, 大澤 豊, 山崎 肇, 成田 一衛

    日本腎臓学会誌   53 ( 6 )   923 - 923   2011.8

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  • Three cases of gastric antral vascular ectasia in chronic renal failure. Reviewed International journal

    Iguchi A, James Kazama J, Komatsu M, Kaneko Y, Iino N, Goto S, Narita I

    Case reports in nephrology and urology   1 ( 1 )   15 - 19   2011.7

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    Gastric antral vascular ectasia (GAVE) is currently recognized as an important cause of gastrointestinal bleeding. Chronic kidney disease (CKD) is associated with a high incidence of GAVE. We report 3 patients with CKD who presented with severe anemia and were diagnosed with GAVE; they were resistant to endoscopic argon plasma coagulation. However, remission of anemia and improvement in GAVE lesions were observed after the initiation of hemodialysis. The pathogenesis of GAVE remains largely unknown, but mechanical stress of the antrum could play an important role. This stress may be reduced by hemodialysis through improvement of uremia-associated gastrointestinal symptoms. Therefore, the initiation of hemodialysis might be effective for intractable GAVE in CKD patients.

    DOI： 10.1159/000332832

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  • 妊娠中にレニン活性が著しく上昇した1例

    後藤 眞, 竹山 綾, 金子 佳賢, 坂爪 実, 成田 一衛, 山田 京子, 菊池 朗, 高桑 好一, 田中 憲一

    新潟医学会雑誌   125 ( 5 )   286 - 286   2011.5

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  • 合併症(その他) 上行結腸癌を腹腔鏡補助下にて治癒切除し、腹膜透析を再開できた1例

    酒巻 裕一, 後藤 眞, 金子 佳賢, 中村 茂樹, 川原 聖佳子, 関根 和彦, 野上 仁, 谷 達夫, 坂爪 実, 西 慎一, 成田 一衛, 下条 文武, 丸山 弘樹

    腎と透析   69 ( 別冊 腹膜透析2010 )   586 - 589   2010.9

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    55歳男。慢性腎不全が進行して51歳時に腹膜透析導入され、以後CAPDを継続していた。今回、便潜血陽性を指摘され、大腸内視鏡検査にて上行結腸肝彎曲よりに0-I sp型の腫瘍性病変を認め、生検で大腸癌、深達度smと診断された。入院時の諸検査より上行結腸癌[A]cSMcN0cH0cM0 cStage Iと術前診断し、腹腔鏡下右半結腸切除術D3郭清を施行した。腫瘍は漿膜面に引きつれを認め、術後診断はMPsN0sH0sP0sM0 sStage Iであった。なお、手術に際しては第3病日より血液透析を週3回併用し、CAPDは手術日早朝に排液した。術後は2日目よりHD週3回を継続し、約2週間でCAPD再開して15日目に退院となった。術後85日目に腹膜機能検査を行ったが、術前と比べ明らかな低下は認めなかった。

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  • IgA腎症患者における尿中Angiotensinogenと組織障害との関連

    井口 昭, 後藤 眞, 金子 佳賢, 坂爪 実, 成田 一衛

    日本腎臓学会誌   52 ( 3 )   372 - 372   2010.5

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  • バスキュラーアクセス作造困難のため右腋窩動脈に人工血管を用いて動脈-動脈ループを作製した1例

    山本 佳子, 酒巻 裕一, 金子 佳賢, 後藤 眞, 西 慎一, 坂爪 実, 成田 一衛, 渡邉 マヤ, 竹久保 賢

    日本透析医学会雑誌   43 ( Suppl.1 )   746 - 746   2010.5

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  • [Membranoproliferative glomerulonephritis]. Reviewed

    Kaneko Y, Narita I

    Nihon Jinzo Gakkai shi   52 ( 7 )   899 - 902   2010

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  • 総排泄腔遺残を伴う慢性腎不全患児の二次献腎移植 鎖骨下静脈長期留置型カテーテルによる血液透析療法

    金子 佳賢, 後藤 眞, 坂爪 実, 成田 一衛, 西 慎一

    今日の移植   22 ( 5 )   551 - 557   2009.10

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  • 2度の急性増悪時に異なる病理像を呈したIgA腎症の一例

    山本 佳子, 大森 健太郎, 金子 佳賢, 飯野 則昭, 後藤 眞, 風間 順一郎, 坂爪 実, 今井 直史, 西 慎一, 成田 一衛

    日本腎臓学会誌   51 ( 6 )   654 - 654   2009.8

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  • ヒト腎疾患およびラット腎疾患モデルにおける糸球体上皮細胞障害分子SM22α発現の病理学的意義

    王 興智, 坂爪 実, 酒巻 裕一, 猪俣 繁, 三浦 隆義, 金子 佳賢, 後藤 眞, 成田 一衛, 下条 文武

    日本腎臓学会誌   51 ( 3 )   236 - 236   2009.4

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  • 各種腎障害モデルにおける腎細胞障害マーカーSM22αの発現

    猪俣 繁, 坂爪 実, 酒巻 裕一, 王 興智, 井口 昭, 和田 真一, 三浦 隆義, 金子 佳賢, 後藤 眞, 成田 一衛, 下条 文武

    日本腎臓学会誌   51 ( 3 )   330 - 330   2009.4

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  • 家族性IgA腎症における糖鎖不全IgA1の測定

    和田 真一, 後藤 眞, 三浦 隆義, 金子 佳賢, 坂爪 実, 成田 一衛

    日本腎臓学会誌   51 ( 3 )   321 - 321   2009.4

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  • Egg on the Table Reviewed

    Junichiro J. Kazama, Yoshikatsu Kaneko

    CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   4 ( 1 )   14 - 15   2009.1

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  • 腎細胞障害マーカーSM22α 抗GBM抗体腎炎慢性期モデルにおける経時的検討

    酒巻 裕一, 坂爪 実, 王 興智, 猪俣 繁, 和田 真一, 三浦 隆義, 金子 佳賢, 後藤 眞, 成田 一衛, 下條 文武

    日本腎臓学会誌   50 ( 3 )   361 - 361   2008.4

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  • 新規ヒト糸球体上皮細胞障害分子SM22αの病理学的意義

    王 興智, 坂爪 実, 酒巻 裕一, 猪俣 繁, 和田 真一, 三浦 隆義, 金子 佳賢, 近藤 大介, 後藤 眞, 成田 一衛, 下条 文武

    日本腎臓学会誌   50 ( 3 )   337 - 337   2008.4

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  • 化膿性脊椎炎に薬剤性間質性腎炎が合併した一例

    三船 大樹, 霜鳥 正明, 川村 和子, 金子 佳賢, 後藤 眞, 今井 直史, 西 慎一, 下條 文武, 宮林 貴大, 捧 博輝

    日本腎臓学会誌   49 ( 6 )   614 - 614   2007.8

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  • A case of nephrotic syndrome 11 yr post-kidney transplantation Reviewed

    S. Nishi, N. Imai, G. Nakamura, M. Ueno, K. Kawamura, Y. Kaneko, S. Goto, B. Alchi, K. Saito, K. Takahashi, F. Gejyo

    Clinical Transplantation   21 ( 18 )   31 - 35   2007.7

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    DOI： 10.1111/j.1399-0012.2007.00715.x

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  • IgA腎症関連遺伝子 現状と今後の展望

    成田 一衛, 三浦 隆義, 金子 佳賢, 後藤 眞, 近藤 大介, 下条 文武

    腎臓   29 ( 3 )   177 - 181   2007.3

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  • [Clinical nephrology]. Reviewed

    Kaneko Y, Narita I, Gejyo F

    Nihon Jinzo Gakkai shi   49 ( 1 )   19 - 24   2007

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  • Expression of allograft inflammatory factor-1 in kidneys: A novel molecular component of podocyte. Reviewed

    Tsubata Y, Sakatsume M, Ogawa A, Alchi B, Kaneko Y, Kuroda T, Kawachi H, Narita I, Yamamoto T, Gejyo F

    Kidney Int   70   1948 - 1954   2006.12

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    DOI： 10.1038/sj.ki.5001941

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  • Bezafibrate suppresses rat antiglomerular basement membrane crescentic glomerulonephritis Reviewed

    D Saga, M Sakatsume, A Ogawa, Y Tsubata, Y Kaneko, T Kuroda, F Sato, J Ajiro, D Kondo, T Miida, Narita, I, F Gejyo

    KIDNEY INTERNATIONAL   67 ( 5 )   1821 - 1829   2005.5

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    DOI： 10.1111/j.1523-1755.2005.00280.x

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  • Osteopontin expression in acute renal allograft rejection Reviewed

    B Alchi, S Nishi, D Kondo, Y Kaneko, A Matsuki, N Imai, M Ueno, S Iguchi, M Sakatsume, Narita, I, T Yamamoto, F Gejyo

    KIDNEY INTERNATIONAL   67 ( 3 )   886 - 896   2005.3

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    DOI： 10.1111/j.1523-1755.2005.00153.x

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  • Transforming growth factor-beta 1 gene polymorphism modifies the histological and clinical manifestations in Japanese patients with IgA nephropathy Reviewed

    F Sato, Narita, I, S Goto, D Kondo, N Saito, J Ajiro, D Saga, A Ogawa, M Kadomura, F Akiyama, Y Kaneko, M Ueno, M Sakatsume, F Gejyo

    TISSUE ANTIGENS   64 ( 1 )   35 - 42   2004.7

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    DOI： 10.1111/j.1399-0039.2004.00256.x

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  • IgA腎症の発症と進展における分子遺伝学的解析

    成田 一衛, 近藤 大介, 後藤 眞, 斎藤 徳子, 佐藤 文則, 安城 淳哉, 嵯峨 大介, 小川 麻, 金子 佳賢, 坂爪 実, 下条 文武

    新潟医学会雑誌   118 ( 3 )   149 - 153   2004.3

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    Language：Japanese   Publisher：新潟医学会  

    腎糸球体メサンギウム領域への免疫グロブリンA(IgA)沈着を伴う増殖性腎炎を特徴とするIgA腎症は,最も頻度の高い原発性糸球体腎炎であり,慢性腎不全の主要な原疾患でもある.本症におけるIgA沈着機序と腎機能低下速度の個人差の機序は不明であるが,遺伝的な背景が,本症の発症と進行の両者に関与する可能性が,近年指摘されてきた.この遺伝的背景を明らかにできれば,IgA腎症の病態と進行機序をより詳細に理解することが可能となる.最近の著者らによる臨床分子遺伝学的な研究を紹介した

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    Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2004&ichushi_jid=J00990&link_issn=&doc_id=20040519030001&doc_link_id=%2Fdg3nigta%2F2004%2F011803%2F001%2F0149-0153%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg3nigta%2F2004%2F011803%2F001%2F0149-0153%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • Impaired IFN-gamma production of V(alpha)24NKT cells in non-remitting sarcoidosis Reviewed

    S Kobayashi, Y Kaneko, K Seino, Y Yamada, S Motohashi, J Koike, K Sugaya, T Kuriyama, S Asano, T Tsuda, H Wakao, M Harada, S Kojo, T Nakayama, M Taniguchi

    INTERNATIONAL IMMUNOLOGY   16 ( 2 )   215 - 222   2004.2

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    DOI： 10.1093/intimm/dxh020

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  • Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity Reviewed

    C Shimizu, H Kawamoto, M Yamashita, M Kimura, E Kondou, Y Kaneko, S Okada, T Tokuhisa, M Yokoyama, M Taniguchi, Y Katsura, T Nakayama

    INTERNATIONAL IMMUNOLOGY   13 ( 1 )   105 - 117   2001.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/intimm/13.1.105

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  • The role of alpha-galactosylceramide-activated V alpha 14 natural killer T cells in the regulation of Th2 cell differentiation Reviewed

    Nakayama T, Yamashita M, Kawano T, Shimizu C, Shibata Y, Kamata T, Kaneko Y, Kobayashi S, Takeda U, Motohashi S, Cui J. Q, Taniguchi M

    International Archives of Allergy and Immunology   124 ( 1-3 )   38 - 42   2001

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Awards

  • 平成27年度学術奨励賞

    2015   新潟県医師会   免疫学的アプローチによる腎炎発症の分子生化学的機序の解明と治療応用

    金子佳賢

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  • International Immunology Outstanding Merit Award 2012

    2013   Japanese Society for Immunology   Integrin α1/β1 and α2/β1 as a receptor for IgA1 in human glomerular mesangial cells in IgA nephropathy.

    Yoshikatsu Kaneko

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  • 第4回腎疾患と高血圧研究会奨励賞

    2012   腎疾患と高血圧研究会   心腎連関モデルマウスにおける近位尿細管でのプロラクチン受容体発現上昇とその役割

    金子佳賢

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Research Projects

  • Gene expression analysis of peripheral blood immune cells induced by anti-ribosomal P protein antibody in patients with systemic lupus erythematosus

    Grant number：24K11595

    2024.4 - 2027.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

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  • Role of Ephrin-Nephrin-Neurexin complex in maintaining slit diaphragm function

    Grant number：22H03086

    2022.4 - 2025.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\17290000 （ Direct Cost: \13300000 、 Indirect Cost：\3990000 ）

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  • 抗リボソームP抗体特異的免疫異常によるSLE病態悪化メカニズムの解明

    Grant number：22K08540

    2022.4 - 2025.3

    System name：科学研究費助成事業

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    佐藤 弘恵, 金子 佳賢, 若松 彩子, 黒澤 陽一

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    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

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  • Role of Ephrin-Nephrin-Neurexin complex in maintaining slit diaphragm function

    Grant number：23K24347

    2022.4 - 2025.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\17290000 （ Direct Cost: \13300000 、 Indirect Cost：\3990000 ）

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  • Mechanism of the glomerular injury after IgA deposition on mesangial cells in IgA nephropathy model mice

    Grant number：20K08588

    2020.4 - 2023.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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  • The role of abnormal mucosal immunity in renal senescence

    Grant number：19H03674

    2019.4 - 2023.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\17030000 （ Direct Cost: \13100000 、 Indirect Cost：\3930000 ）

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  • ループス腎炎の発症病態における抗リボソームP抗体の関与

    2018.4 - 2021.3

    System name：科学研究費 基盤研究 (C)

    Awarding organization：日本学術振興会

    佐藤弘惠

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    Grant type：Competitive

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  • 腎糸球体メサンギウム細胞とIgA1の相互作用および関連分子による修飾機構

    2016.4 - 2019.3

    System name：科学研究費 基盤研究 (C)

    Awarding organization：日本学術振興会

    金子佳賢

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    Authorship：Principal investigator  Grant type：Competitive

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  • 腎臓病モデルマウスにおける加齢の影響とプロラクチンの尿蛋白減少作用

    2015.4 - 2016.3

    System name：ノバルティス老化および老年医学研究基金研究助成

    Awarding organization：ノバルティスファーマ

    金子佳賢

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    Authorship：Principal investigator  Grant type：Competitive

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  • ホロゲノム解析によるIgA腎症の病態解析と治療ターゲット探索

    2014.4 - 2018.3

    System name：科学研究費 基盤研究 (B)

    Awarding organization：日本学術振興会

    成田一衛

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    Grant type：Competitive

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  • 腎臓病患者におけるiPS細胞由来腎糸球体上皮細胞の機能解析と病態解明

    2014.4 - 2017.3

    System name：科学研究費 挑戦的萌芽研究

    Awarding organization：日本学術振興会

    成田一衛

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    Grant type：Competitive

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  • 肥満ホルモンと免疫細胞の相互作用による腎疾患への関与

    2014.4 - 2015.3

    System name：平成26年度調査研究助成金

    Awarding organization：鈴木謙三記念医科学応用研究財団

    金子佳賢

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    Authorship：Principal investigator  Grant type：Competitive

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  • 腎糸球体上皮細胞におけるプロラクチン受容体の腎疾患における役割の解明

    2012.4 - 2015.3

    System name：科学研究費 基盤研究 (C)

    Awarding organization：日本学術振興会

    金子佳賢

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    Authorship：Principal investigator  Grant type：Competitive

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  • IgA腎症におけるメサンギウム細胞へのIgA沈着メカニズムの解明と治療への応用

    2009.4 - 2012.3

    System name：科学研究費 若手研究 (B)

    Awarding organization：日本学術振興会

    金子佳賢

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    Authorship：Principal investigator  Grant type：Competitive

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  • 糖鎖不全IgAに対する新規受容体の同定と解析によるIgA腎症発症機序の解明

    2008.4 - 2011.3

    System name：科学研究費 基盤研究 (B)

    Awarding organization：日本学術振興会

    金子佳賢

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    Authorship：Principal investigator  Grant type：Competitive

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  • 糖鎖不全IgAに対するメサンギウム細胞新規受容体の同定とIgA腎症発症メカニズムの解明

    2008.4 - 2009.3

    System name：第37回かなえ医薬振興財団研究助成金

    Awarding organization：かなえ医薬振興財団

    金子佳賢

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    Authorship：Principal investigator  Grant type：Competitive

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  • ガラクトース欠損IgAと結合するメサンギウム細胞新規受容体の同定

    2007.4 - 2008.3

    System name：2007年度IgA腎症研究会研究助成金

    Awarding organization：IgA腎症研究会

    金子佳賢

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    Authorship：Principal investigator  Grant type：Competitive

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  • 免疫グロブリンによる免疫抑制機序の解明

    2005.4 - 2006.3

    System name：平成16年度上原記念生命科学財団海外留学助成リサーチフェローシップ

    Awarding organization：上原記念生命科学財団

    金子佳賢

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    Authorship：Principal investigator  Grant type：Competitive

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  • マクロファージ抑制性レセプターFcγRIIBの発現調節機構の解明と疾患モデルへの臨床応用

    2004.4 - 2005.3

    System name：第20回内藤記念科学振興財団海外研究留学助成金

    Awarding organization：内藤記念科学振興財団

    金子佳賢

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    Authorship：Principal investigator  Grant type：Competitive

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  • マクロファージ抑制性レセプターFcγRIIBの発現調節機構の解明と疾患モデルへの臨床応用

    2004.4 - 2005.3

    System name：第32回かなえ医薬振興財団海外留学助成金

    Awarding organization：かなえ医薬振興財団

    金子佳賢

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    Authorship：Principal investigator  Grant type：Competitive

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Teaching Experience

  • 疾病の原因と成り立ち

    2026
    Institution name：新潟大学

  • 成人・老年看護学特講演習

    2026
    Institution name：新潟大学

  • 臨床薬理学

    2026
    Institution name：新潟大学

  • 病態生理学

    2026
    Institution name：新潟大学

  • 成人・老年看護技術論II

    2026
    Institution name：新潟大学

  • スタディスキルズ (看護)

    2026
    Institution name：新潟大学

  • 成人・老年看護技術論I

    2026
    Institution name：新潟大学

  • 救急救護法

    2026
    Institution name：新潟大学

  • 疾病の予防と治療

    2026
    Institution name：新潟大学

  • 疾病の成因と治療

    2026
    Institution name：新潟大学

  • 治療法概説

    2026
    Institution name：新潟大学

  • 病態論

    2026
    Institution name：新潟大学

  • 成人・老年看護学特講

    2026
    Institution name：新潟大学

  • アキュートケア看護論

    2026
    Institution name：新潟大学

  • 人体の構造と機能II

    2026
    Institution name：新潟大学

  • 腎分子生物学演習

    2026
    Institution name：新潟大学

  • 人体の構造と機能II(生理学)

    2024
    Institution name：新潟大学

  • 内科学2

    2011
    -
    2020
    Institution name：新潟大学

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