Updated on 2024/07/16

写真a

 
KAIZU Motoki
 
Organization
University Medical and Dental Hospital Radiation Oncology Lecturer
Title
Lecturer
Other name(s)
Motoki Kaidu
External link

Degree

  • 医学博士(医学) ( 2008.9   新潟大学 )

Research Areas

  • Life Science / Radiological sciences  / 放射線治療

Research History (researchmap)

  • Niigata University   University Medical and Dental Hospital Radiation Oncology   Lecturer

    2015.4

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  • Niigata University   University Medical and Dental Hospital Division of Radiology   Assistant Professor

    2012.5 - 2015.3

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  • Niigata University   University Medical and Dental Hospital Radiology   Specially Appointed Assistant Professor

    2010.10 - 2012.4

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Research History

  • Niigata University   University Medical and Dental Hospital Radiation Oncology   Lecturer

    2015.4

  • Niigata University   University Medical and Dental Hospital Division of Radiology   Assistant Professor

    2012.5 - 2015.3

  • Niigata University   University Medical and Dental Hospital Radiology   Specially Appointed Assistant Professor

    2010.10 - 2012.4

Qualification acquired

  • Doctor

 

Papers

  • Assessing tumor volumetric reduction with consideration for setup errors based on mathematical tumor model and microdosimetric kinetic model in single-isocenter VMAT for brain metastases

    Hisashi Nakano, Takehiro Shiinoki, Satoshi Tanabe, Satoru Utsunomiya, Motoki Kaidu, Teiji Nishio, Hiroyuki Ishikawa

    Physical and Engineering Sciences in Medicine   2024.6

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s13246-024-01451-8

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    Other Link: https://link.springer.com/article/10.1007/s13246-024-01451-8/fulltext.html

  • Prediction of patient‐specific quality assurance for volumetric modulated arc therapy using radiomics‐based machine learning with dose distribution Reviewed

    Natsuki Ishizaka, Tomotaka Kinoshita, Madoka Sakai, Shunpei Tanabe, Hisashi Nakano, Satoshi Tanabe, Sae Nakamura, Kazuki Mayumi, Shinya Akamatsu, Takayuki Nishikata, Takeshi Takizawa, Takumi Yamada, Hironori Sakai, Motoki Kaidu, Ryuta Sasamoto, Hiroyuki Ishikawa, Satoru Utsunomiya

    Journal of Applied Clinical Medical Physics   2023.11

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/acm2.14215

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  • Deep learning‐based detection and classification of multi‐leaf collimator modeling errors in volumetric modulated radiation therapy

    Sae Nakamura, Madoka Sakai, Natsuki Ishizaka, Kazuki Mayumi, Tomotaka Kinoshita, Shinya Akamatsu, Takayuki Nishikata, Shunpei Tanabe, Hisashi Nakano, Satoshi Tanabe, Takeshi Takizawa, Takumi Yamada, Hironori Sakai, Motoki Kaidu, Ryuta Sasamoto, Hiroyuki Ishikawa, Satoru Utsunomiya

    Journal of Applied Clinical Medical Physics   2023.8

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    Purpose

    The purpose of this study was to create and evaluate deep learning‐based models to detect and classify errors of multi‐leaf collimator (MLC) modeling parameters in volumetric modulated radiation therapy (VMAT), namely the transmission factor (TF) and the dosimetric leaf gap (DLG).

    Methods

    A total of 33 clinical VMAT plans for prostate and head‐and‐neck cancer were used, assuming a cylindrical and homogeneous phantom, and error plans were created by altering the original value of the TF and the DLG by ± 10, 20, and 30% in the treatment planning system (TPS). The Gaussian filters of and 1.0 were applied to the planar dose maps of the error‐free plan to mimic the measurement dose map, and thus dose difference maps between the error‐free and error plans were obtained. We evaluated 3 deep learning‐based models, created to perform the following detections/classifications: (1) error‐free versus TF error, (2) error‐free versus DLG error, and (3) TF versus DLG error. Models to classify the sign of the errors were also created and evaluated. A gamma analysis was performed for comparison.

    Results

    The detection and classification of TF and DLG error were feasible for ; however, a considerable reduction of accuracy was observed for depending on the magnitude of error and treatment site. The sign of errors was detectable by the specifically trained models for and 1.0. The gamma analysis could not detect errors.

    Conclusions

    We demonstrated that the deep learning‐based models could feasibly detect and classify TF and DLG errors in VMAT dose distributions, depending on the magnitude of the error, treatment site, and the degree of mimicked measurement doses.

    DOI: 10.1002/acm2.14136

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  • Verification of Qfix Encompass™ couch modeling using the Acuros XB algorithm and HypeArc™ using a high-spatial-resolution two-dimensional diode array. International journal

    Takumi Yamada, Hisashi Nakano, Satoshi Tanabe, Tatsuya Sakai, Shunpei Tanabe, Tetsuya Oka, Hironori Sakai, Tomoya Oshikane, Toshimichi Nakano, Atsushi Ohta, Tsutomu Kanazawa, Motoki Kaidu, Hiroyuki Ishikawa

    Medical dosimetry : official journal of the American Association of Medical Dosimetrists   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    We modeled the Qfix Encompass™ immobilization system and further verified the calculated dose distribution of the AcurosXB (AXB) dose calculation algorithm using SRS MapCHECKⓇ (SRSMC) in the HyperArc™ (HA) clinical plan. An Encompass system with a StereoPHAN™ QA phantom was scanned by SOMATOM go.Sim and imported to an Eclipse™ treatment planning system to create a treatment plan for Encompass modeling. The Encompass modeling was performed in the StereoPHAN with a pinpoint ion chamber for 6 MV and 6 MV flattening filter free (6 MV FFF), and 2 × 2 cm2, 4 × 4 cm2, and 6 × 6 cm2 irradiation field sizes. The dose calculation algorithm used was AXB ver. 15.5 with a 1.0 mm calculation grid size. The Hounsfield unit (HU) values of the Encompass modeling were set to 400, -100, -200, and -300 for Encompass, and -400, -600, -700, and -800 for the Encompass base. We evaluated the dose distribution after Encompass modeling by SRSMC using gamma analysis in 12 patients. We adopted HU values of -200 for Encompass, -800 for Encompass base for 6 MV, and -200 for Encompass and -700 for Encompass. Base for 6 MV FFF was adopted as the HU values for the Encompass modeling based on the measurement results. The proposed Encompass modeling resulted in a mean pass rate evaluation >98% for both 6 MV and 6 MV FFF when the 1%/1 mm criterion was used, demonstrating that the proposed HU value can be adopted to calculate more accurate dose distributions.

    DOI: 10.1016/j.meddos.2023.06.002

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  • Mathematical model combined with microdosimetric kinetic model for tumor volume calculation in stereotactic body radiation therapy

    Hisashi Nakano, Takehiro Shiinoki, Satoshi Tanabe, Satoru Utsunomiya, Takeshi Takizawa, Motoki Kaidu, Teiji Nishio, Hiroyuki Ishikawa

    Scientific Reports   13 ( 1 )   2023.7

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    We proposed a new mathematical model that combines an ordinary differential equation (ODE) and microdosimetric kinetic model (MKM) to predict the tumor-cell lethal effect of Stereotactic body radiation therapy (SBRT) applied to non-small cell lung cancer (NSCLC). The tumor growth volume was calculated by the ODE in the multi-component mathematical model (MCM) for the cell lines NSCLC A549 and NCI-H460 (H460). The prescription doses 48 Gy/4 fr and 54 Gy/3 fr were used in the SBRT, and the effect of the SBRT on tumor cells was evaluated by the MKM. We also evaluated the effects of (1) linear quadratic model (LQM) and the MKM, (2) varying the ratio of active and quiescent tumors for the total tumor volume, and (3) the length of the dose-delivery time per fractionated dose (t<sub>inter</sub>) on the initial tumor volume. We used the ratio of the tumor volume at 1 day after the end of irradiation to the tumor volume before irradiation to define the radiation effectiveness value (REV). The combination of MKM and MCM significantly reduced REV at 48 Gy/4 fr compared to the combination of LQM and MCM. The ratio of active tumors and the prolonging of t<sub>inter</sub> affected the decrease in the REV for A549 and H460 cells. We evaluated the tumor volume considering a large fractionated dose and the dose-delivery time by combining the MKM with a mathematical model of tumor growth using an ODE in lung SBRT for NSCLC A549 and H460 cells.

    DOI: 10.1038/s41598-023-38232-4

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    Other Link: https://www.nature.com/articles/s41598-023-38232-4

  • Multicomponent mathematical model for tumor volume calculation with setup error using single-isocenter stereotactic radiotherapy for multiple brain metastases

    Hisashi Nakano, Takehiro Shiinoki, Satoshi Tanabe, Toshimichi Nakano, Takeshi Takizawa, Satoru Utsunomiya, Madoka Sakai, Shunpei Tanabe, Atsushi Ohta, Motoki Kaidu, Teiji Nishio, Hiroyuki Ishikawa

    Physical and Engineering Sciences in Medicine   2023.3

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s13246-023-01241-8

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    Other Link: https://link.springer.com/article/10.1007/s13246-023-01241-8/fulltext.html

  • The Relationship between the Contouring Time of the Metal Artifacts Area and Metal Artifacts in Head and Neck Radiotherapy Reviewed

    Kouji Katsura, Satoshi Tanabe, Hisashi Nakano, Madoka Sakai, Atsushi Ohta, Motoki Kaidu, Marie Soga, Taichi Kobayashi, Masaki Takamura, Takafumi Hayashi

    Tomography   9 ( 1 )   98 - 104   2023.1

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    Publishing type:Research paper (scientific journal)   Publisher:MDPI AG  

    (1) Background: The impacts of metal artifacts (MAs) on the contouring workload for head and neck radiotherapy have not yet been clarified. Therefore, this study evaluated the relationship between the contouring time of the MAs area and MAs on head and neck radiotherapy treatment planning. (2) Methods: We used treatment planning computed tomography (CT) images for head and neck radiotherapy. MAs were classified into three severities by the percentage of CT images containing MAs: mild (&lt;25%), moderate (25–75%), and severe (&gt;75%). We randomly selected nine patients to evaluate the relationship between MAs and the contouring time of the MAs area. (3) Results: The contouring time of MAs showed moderate positive correlations with the MAs volume and the number of CT images containing MAs. Interobserver reliability of the extracted MAs volume and contouring time were excellent and poor, respectively. (4) Conclusions: Our study suggests that the contouring time of MAs areas is related to individual commitment rather than clinical experience. Therefore, the development of software combining metal artifact reduction methods with automatic contouring methods is necessary to reducing interobserver variability and contouring workload.

    DOI: 10.3390/tomography9010009

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  • The impact of target positioning error and tumor size on radiobiological parameters in robotic stereotactic radiosurgery for metastatic brain tumors.

    Takeshi Takizawa, Satoshi Tanabe, Hisashi Nakano, Satoru Utsunomiya, Madoka Sakai, Katsuya Maruyama, Shigekazu Takeuchi, Toshimichi Nakano, Atsushi Ohta, Motoki Kaidu, Hiroyuki Ishikawa, Kiyoshi Onda

    Radiological physics and technology   2022.3

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    This study aimed to evaluate the effect of target positioning error (TPE) on radiobiological parameters, such as tumor control probability (TCP) and normal tissue complication probability (NTCP), in stereotactic radiosurgery (SRS) for metastatic brain tumors of different sizes using CyberKnife. The reference SRS plans were created using the circular cone of the CyberKnife for each spherical gross tumor volume (GTV) with diameters (φ) of 5, 7.5, 10, 15, and 20 mm, contoured on computed tomography images of the head phantom. Subsequently, plans involving TPE were created by shifting the beam center by 0.1-2.0 mm in three dimensions relative to the reference plans using the same beam arrangements. Conformity index (CI), generalized equivalent uniform dose (gEUD)-based TCP, and NTCP of estimated brain necrosis were evaluated for each plan. When the gEUD parameter "a" was set to - 10, the CI and TCP for the reference plan at the φ5-mm GTV were 0.90 and 80.8%, respectively. The corresponding values for plans involving TPE of 0.5-mm, 1.0-mm, and 2.0-mm were 0.62 and 77.4%, 0.40 and 62.9%, and 0.12 and 7.2%, respectively. In contrast, the NTCP for all GTVs were the same. The TCP for the plans involving a TPE of 2-mm was 7.2% and 68.8% at the φ5-mm and φ20-mm GTV, respectively. The TPEs corresponding to a TCP reduction rate of 3% at the φ5-mm and φ20-mm GTV were 0.41 and 0.99 mm, respectively. TPE had a significant effect on TCP in SRS for metastatic brain tumors using CyberKnife, particularly for small GTVs.

    DOI: 10.1007/s12194-022-00655-5

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  • Radiobiological evaluation considering setup error on single‐isocenter irradiation in stereotactic radiosurgery

    Hisashi Nakano, Satoshi Tanabe, Ryuta Sasamoto, Takeshi Takizawa, Satoru Utsunomiya, Madoka Sakai, Toshimichi Nakano, Atsushi Ohta, Motoki Kaidu, Hiroyuki Ishikawa

    Journal of Applied Clinical Medical Physics   22 ( 7 )   266 - 275   2021.6

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/acm2.13322

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/acm2.13322

  • A comparative study of high-dose-rate brachytherapy boost combined with external beam radiation therapy versus external beam radiation therapy alone for high-risk prostate cancer

    Tomoya Oshikane, Motoki Kaidu, Eisuke Abe, Atsushi Ohta, Hirotake Saito, Toshimichi Nakano, Moe Honda, Satoshi Tanabe, Satoru Utsunomiya, Ryuta Sasamoto, Fumio Ishizaki, Takashi Kasahara, Tsutomu Nishiyama, Yoshihiko Tomita, Hidefumi Aoyama, Hiroyuki Ishikawa

    Journal of Radiation Research   62 ( 3 )   525 - 532   2021.5

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    Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    <title>Abstract</title>
    We aimed to compare the outcomes of high-dose-rate brachytherapy (HDR-BT) boost and external beam radiation therapy (EBRT) alone for high-risk prostate cancer. This was a single-center, retrospective and observational study. Consecutive patients who underwent initial radical treatment by HDR-BT boost or EBRT alone from June 2009 to May 2016 at the Niigata University Medical and Dental Hospital, Japan were included. A total of 96 patients underwent HDR-BT boost, and 61 underwent EBRT alone. The prescription dose of HDR-BT boost was set to 18 Gy twice a day with EBRT 39 Gy/13 fractions. The dose for EBRT alone was mostly 70 Gy/28 fractions. The high-risk group received &amp;gt;6 months of prior androgen deprivation therapy. Overall survival, biochemical-free survival, local control and distant metastasis-free survival rates at 5 years were analyzed. The incidence of urological and gastrointestinal late adverse events of Grade 2 and above was also summarized. In the National Comprehensive Cancer Network (NCCN) high-risk calssification, HDR-BT boost had a significantly higher biochemical-free survival rate at 5 years (98.9% versus 90.7%, P = 0.04). Urethral strictures were more common in the HDR-BT boost group. We will continuously observe the progress of the study patients and determine the longer term results.

    DOI: 10.1093/jrr/rrab006

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  • Detecting MLC modeling errors using radiomics‐based machine learning in patient‐specific QA with an EPID for intensity‐modulated radiation therapy

    Madoka Sakai, Hisashi Nakano, Daisuke Kawahara, Satoshi Tanabe, Takeshi Takizawa, Akihiro Narita, Takumi Yamada, Hironori Sakai, Masataka Ueda, Ryuta Sasamoto, Motoki Kaidu, Hidefumi Aoyama, Hiroyuki Ishikawa, Satoru Utsunomiya

    Medical Physics   48 ( 3 )   991 - 1002   2021.3

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/mp.14699

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/mp.14699

  • Maximum distance in single-isocenter technique of stereotactic radiosurgery with rotational error using margin-based analysis

    Hisashi Nakano, Satoshi Tanabe, Takumi Yamada, Satoru Utsunomiya, Takeshi Takizawa, Madoka Sakai, Ryuta Sasamoto, Hironori Sakai, Toshimichi Nakano, Hirotake Saito, Atsushi Ohta, Motoki Kaidu, Hiroyuki Ishikawa

    Radiological Physics and Technology   14 ( 1 )   57 - 63   2021.3

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1007/s12194-020-00602-2

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    Other Link: http://link.springer.com/article/10.1007/s12194-020-00602-2/fulltext.html

  • Calculated relative biological effectiveness (RBE) for initial DNA double-strand breaks (DSB) from flattening filter and flattening filter-free 6 MV X-ray fields

    Hisashi Nakano, Daisuke Kawahara, Satoshi Tanabe, Satoru Utsunomiya, Takeshi Takizawa, Madoka Sakai, Toshimichi Nakano, Atsushi Ohta, Motoki Kaidu, Hiroyuki Ishikawa

    BJR|Open   3 ( 1 )   20200072 - 20200072   2021.1

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    Publishing type:Research paper (scientific journal)   Publisher:British Institute of Radiology  

    <sec><title>Objectives:</title> We evaluated the radiobiological effectiveness based on the yields of DNA double-strand breaks (DSBs) of field induction with flattening filter (FF) and FF-free (FFF) photon beams.

    </sec><sec><title>Methods:</title> We used the particle and heavy ion transport system (PHITS) and a water equivalent phantom (30 × 30 × 30 cm<sup>3</sup>) to calculate the physical qualities of the dose-mean lineal energy (y<sub>D</sub>) with 6 MV FF and FFF. The relative biological effectiveness based on the yields of DNA-DSBs (RBE<sub>DSB</sub>) was calculated for standard radiation such as 220 kVp X-rays by using the estimating yields of SSBs and DSBs. The measurement points used to calculate the in-field y<sub>D</sub> and RBE<sub>DSB</sub> were located at a depth of 3, 5, and 10 cm in the water equivalent phantom on the central axis. Measurement points at 6, 8, and 10 cm in the lateral direction of each of the three depths from the central axis were set to calculate the out-of-field y<sub>D</sub> and RBE<sub>DSB</sub>.

    </sec><sec><title>Results:</title> The RBE<sub>DSB</sub> of FFF in-field was 1.7% higher than FF at each measurement depth. The RBE<sub>DSB</sub> of FFF out-of-field was 1.9 to 6.4% higher than FF at each depth measurement point. As the distance to out-of-field increased, the RBE<sub>DSB</sub> of FFF rose higher than those of FF. FFF has a larger RBE<sub>DSB</sub> than FF based on the yields of DNA-DSBs as the distance to out-of-field increased.

    </sec><sec><title>Conclusions:</title> The out-of-field radiobiological effect of FFF could thus be greater than that of FF since the spreading of the radiation dose out-of-field with FFF could be a concern compared to the FF.

    </sec><sec><title>Advances in knowledge:</title> The RBE<sub>DSB</sub> of FFF of out-of-field might be larger than FF.

    </sec>

    DOI: 10.1259/bjro.20200072

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  • Effect of setup error in the single‐isocenter technique on stereotactic radiosurgery for multiple brain metastases

    Hisashi Nakano, Satoshi Tanabe, Satoru Utsunomiya, Takumi Yamada, Ryuta Sasamoto, Toshimichi Nakano, Hirotake Saito, Takeshi Takizawa, Hironori Sakai, Atsushi Ohta, Eisuke Abe, Motoki Kaidu, Hidefumi Aoyama

    Journal of Applied Clinical Medical Physics   21 ( 12 )   155 - 165   2020.12

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/acm2.13081

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/acm2.13081

  • Radiobiological effects of the interruption time with Monte Carlo Simulation on multiple fields in photon beams

    Hisashi Nakano, Daisuke Kawahara, Satoshi Tanabe, Satoru Utsunomiya, Takeshi Takizawa, Madoka Sakai, Hirotake Saito, Atsushi Ohta, Motoki Kaidu, Hiroyuki Ishikawa

    Journal of Applied Clinical Medical Physics   21 ( 12 )   288 - 294   2020.12

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/acm2.13110

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/acm2.13110

  • Efficacy and Safety of the Radiotherapy for Liver Cancer: Assessment of Local Controllability and its Role in Multidisciplinary Therapy. International journal

    Marina Ohkoshi-Yamada, Kenya Kamimura, Osamu Shibata, Shinichi Morita, Motoki Kaidu, Toshimichi Nakano, Katsuya Maruyama, Atsushi Ota, Hirotake Saito, Nobuko Yamana, Tomoya Oshikane, Yukiyo Goto, Natsumi Yoshimura, Satoshi Tanabe, Hisashi Nakano, Madoka Sakai, Yuto Tanaka, Yohei Koseki, Yoshihisa Arao, Hiroyuki Abe, Toru Setsu, Akira Sakamaki, Takeshi Yokoo, Hiroteru Kamimura, Hidefumi Aoyama, Shuji Terai

    Cancers   12 ( 10 )   2020.10

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    This study investigated the efficacy and safety of radiotherapy as part of multidisciplinary therapy for advanced hepatocellular carcinoma (HCC). Clinical data of 49 HCC patients treated with radiotherapy were assessed retrospectively. The efficacy of radiotherapy was assessed by progression-free survival, disease control rate, and overall survival. Safety was assessed by symptoms and hematological assay, and changes in hepatic reserve function were determined by Child-Pugh score and albumin-bilirubin (ALBI) score. Forty patients underwent curative radiotherapy, and nine patients with portal vein tumor thrombus (PVTT) underwent palliative radiotherapy as part of multidisciplinary therapy. Local disease control for curative therapy was 80.0% and stereotactic body radiotherapy was 86.7% which was greater than that of conventional radiotherapy (60.0%). Patients with PVTT had a median observation period of 651 days and 75% three-year survival when treated with multitherapy, including radiotherapy for palliative intent, transcatheter arterial chemoembolization, and administration of molecular targeted agents. No adverse events higher than grade 3 and no changes in the Child-Pugh score and ALBI score were seen. Radiotherapy is safe and effective for HCC treatment and can be a part of multidisciplinary therapy.

    DOI: 10.3390/cancers12102955

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  • 高リスク前立腺癌に対する外照射療法併用高線量率組織内照射療法の制癌効果

    笠原 隆, 石崎 文雄, 丸山 亮, 山名 一寿, 海津 元樹, 押金 智哉, 西山 勉, 冨田 善彦

    日本癌治療学会学術集会抄録集   58回   P - 351   2020.10

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    Language:Japanese   Publisher:(一社)日本癌治療学会  

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  • High-dose-rate brachytherapy and hypofractionated external beam radiotherapy combined with long-term androgen deprivation therapy for very high-risk prostate cancer

    Takashi Kasahara, Fumio Ishizaki, Akira Kazama, Eri Yuki, Kazutoshi Yamana, Ryo Maruyama, Tomoya Oshikane, Motoki Kaidu, Hidefumi Aoyama, Vladimir Bilim, Tsutomu Nishiyama, Yoshihiko Tomita

    INTERNATIONAL JOURNAL OF UROLOGY   27 ( 9 )   800 - 806   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Objective To estimate the outcomes of high-dose-rate brachytherapy combined with hypofractionated external beam radiotherapy in prostate cancer patients classified as very high risk by the National Comprehensive Cancer Network. Methods Between June 2009 and September 2015, 66 patients meeting the criteria for very high-risk disease received high-dose-rate brachytherapy (2 fractions of 9 Gy) as a boost of external beam radiotherapy (13 fractions of 3 Gy). Androgen deprivation therapy was administered for approximately 3 years. Biochemical failure was assessed using the Phoenix definition. Results The median follow-up period was 53 months from the completion of radiotherapy. The 5-year biochemical failure-free, distant metastasis-free, prostate cancer-specific and overall survival rates were 88.7, 89.2, 98.5 and 97.0%, respectively. The independent contribution of each component of the very high-risk criteria was assessed in multivariable models. Primary Gleason pattern 5 was associated with increased risks of biochemical failure (P = 0.017) and distant metastasis (P = 0.049), whereas clinical stage >= T3b or >4 biopsy cores with Gleason score 8-10 had no significant impact on the two outcomes. Grade 3 genitourinary toxicities were observed in two (3.0%) patients, whereas no grade >= 3 gastrointestinal toxicities occurred. Conclusions The present study shows that this multimodal approach provides potentially excellent cancer control and acceptable associated morbidity for very high-risk disease. Patients with primary Gleason pattern 5 are at a higher risk of poor outcomes, indicating the need for more aggressive approaches in these cases.

    DOI: 10.1111/iju.14305

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  • High-dose-rate brachytherapy and hypofractionated external beam radiotherapy combined with long-term androgen deprivation therapy for very high-risk prostate cancer. International journal

    Takashi Kasahara, Fumio Ishizaki, Akira Kazama, Eri Yuki, Kazutoshi Yamana, Ryo Maruyama, Tomoya Oshikane, Motoki Kaidu, Hidefumi Aoyama, Vladimir Bilim, Tsutomu Nishiyama, Yoshihiko Tomita

    International journal of urology : official journal of the Japanese Urological Association   27 ( 9 )   800 - 806   2020.9

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    OBJECTIVE: To estimate the outcomes of high-dose-rate brachytherapy combined with hypofractionated external beam radiotherapy in prostate cancer patients classified as very high risk by the National Comprehensive Cancer Network. METHODS: Between June 2009 and September 2015, 66 patients meeting the criteria for very high-risk disease received high-dose-rate brachytherapy (2 fractions of 9 Gy) as a boost of external beam radiotherapy (13 fractions of 3 Gy). Androgen deprivation therapy was administered for approximately 3 years. Biochemical failure was assessed using the Phoenix definition. RESULTS: The median follow-up period was 53 months from the completion of radiotherapy. The 5-year biochemical failure-free, distant metastasis-free, prostate cancer-specific and overall survival rates were 88.7, 89.2, 98.5 and 97.0%, respectively. The independent contribution of each component of the very high-risk criteria was assessed in multivariable models. Primary Gleason pattern 5 was associated with increased risks of biochemical failure (P = 0.017) and distant metastasis (P = 0.049), whereas clinical stage ≥T3b or >4 biopsy cores with Gleason score 8-10 had no significant impact on the two outcomes. Grade 3 genitourinary toxicities were observed in two (3.0%) patients, whereas no grade ≥3 gastrointestinal toxicities occurred. CONCLUSIONS: The present study shows that this multimodal approach provides potentially excellent cancer control and acceptable associated morbidity for very high-risk disease. Patients with primary Gleason pattern 5 are at a higher risk of poor outcomes, indicating the need for more aggressive approaches in these cases.

    DOI: 10.1111/iju.14305

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  • Dosimetric comparison of analytic anisotropic algorithm and Acuros XB algorithm in VMAT plans for high-grade glioma Reviewed

    Takeshi Takizawa, Satoshi Tanabe, Satoru Utsunomiya, Hisashi Nakano, Takumi Yamada, Hironori Sakai, Atsushi Ohta, Hirotake Saito, Toshimichi Nakano, Eisuke Abe, Motoki Kaidu, Hidefumi Aoyama

    Physica Medica   73   73 - 82   2020.5

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    DOI: 10.1016/j.ejmp.2020.04.007

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  • The neurocognitive function change criteria after whole-brain radiation therapy for brain metastasis, in reference to health-related quality of life changes: a prospective observation study. Reviewed International journal

    Toshimichi Nakano, Hidefumi Aoyama, Hirotake Saito, Satoshi Tanabe, Kensuke Tanaka, Katsuya Maruyama, Tomoya Oshikane, Atsushi Ohta, Eisuke Abe, Motoki Kaidu

    BMC cancer   20 ( 1 )   66 - 66   2020.1

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    BACKGROUND: We sought to construct the optimal neurocognitive function (NCF) change criteria sensitive to health-related quality of life (HR-QOL) in patients who have undergone whole-brain radiation therapy (WBRT) for brain metastasis. METHODS: We categorized the patients by the changes of NCF into groups of improvement versus deterioration if at least one domain showed changes that exceeded the cut-off while other domains remained stable. The remaining patients were categorized as stable, and the patients who showed both significant improvement and deterioration were categorized as 'both.' We examined the clinical meaning of NCF changes using the cut-off values 1.0, 1.5, and 2.0 SD based on the percentage of patients whose HR-QOL changes were ≥ 10 points. RESULTS: Baseline, 4-month and 8-month data were available in 78, 41 (compliance; 85%), and 29 (81%) patients, respectively. At 4 months, improvement/stable/deterioration/both was seen in 15%/12%/41%/32% of the patients when 1.0 SD was used; 19%/22%/37%/22% with 1.5 SD, and 17%/37%/37%/9% with 2.0 SD. The HR-QOL scores on the QLQ-C30 functional scale were significantly worse in the deterioration group versus the others with 1.0 SD (p = 0.013) and 1.5 SD (p = 0.015). With 1.5 SD, the HR-QOL scores on the QLQ-BN20 was significantly better in the improvement group versus the others (p = 0.033). However, when 'both' was included in 'improvement' or 'deterioration,' no significant difference in HR-QOL was detected. CONCLUSIONS: The NCF cut-off of 1.5 SD and the exclusion of 'both' patients from the 'deterioration' and 'improvement' groups best reflects HR-QOL changes.

    DOI: 10.1186/s12885-020-6559-3

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  • The association between oral candidiasis and severity of chemoradiotherapy-induced dysphagia in head and neck cancer patients: A retrospective cohort study Reviewed

    Hirotake Saito, Ryusuke Shodo, Keisuke Yamazaki, Kouji Katsura, Yushi Ueki, Toshimichi Nakano, Tomoya Oshikane, Nobuko Yamana, Satoshi Tanabe, Satoru Utsunomiya, Atsushi Ohta, Eisuke Abe, Motoki Kaidu, Ryuta Sasamoto, Hidefumi Aoyama

    Clinical and Translational Radiation Oncology   20   13 - 18   2020.1

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    DOI: 10.1016/j.ctro.2019.10.006

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  • 多発脳転移に対する単一アイソセンタ照射法における患者セットアップの並進誤差が線量不確かさに及ぼす影響

    中野 永, 棚邊 哲史, 宇都宮 悟, 中野 智成, 斎藤 紘丈, 滝澤 健司, 山田 巧, 坂井 裕則, 太田 篤, 阿部 英輔, 海津 元樹, 青山 英史

    定位的放射線治療   24   81 - 89   2020.1

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  • 消化器癌脳転移に対する定位照射の治療成績

    斎藤 紘丈, 中野 智成, 押金 智哉, 太田 篤, 阿部 英輔, 海津 元樹, 青山 英史

    定位的放射線治療   24   73 - 79   2020.1

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    定位放射線治療を受けた消化器癌(胃、小腸、大腸、肝臓、胆、膵)からの脳転移患者の治療成績について検討した。25名の消化器癌脳転移患者が当科を受診し、生存期間中央値は5.1ヵ月であった。25名のうち定位照射を施行されたのは5人(男性4人、女性1人、中央値77歳)で、原発巣は肝臓4人、直腸1人であった。初診時の病期はstage Iが1人、stage IIIが4人、不明が1人であり、4人が脳転移診断時に頭蓋外転移をすでに有していた。治療方針は定位照射単独が3人、定位+全脳照射が1人、定位+全脳照射+手術が1人であった。定位照射の線量分割は22Gy/1回が5病変、28Gy/4回が2病変、32Gy/4回が2病変、30.4Gy/4回が1病変であった。定位照射後の一次治療効果判定はPDが3人、制御が1人、体幹部転移の増大のため未評価が1人であった。適切な画像フォローアップおよび体幹部転移のコントロールを改善することが予後改善につながる可能性があると考えられた。

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  • 多発脳転移に対する単一アイソセンタ照射法における患者セットアップの並進誤差が線量不確かさに及ぼす影響

    中野 永, 棚邊 哲史, 宇都宮 悟, 中野 智成, 斎藤 紘丈, 滝澤 健司, 山田 巧, 坂井 裕則, 太田 篤, 阿部 英輔, 海津 元樹, 青山 英史

    定位的放射線治療   24   81 - 89   2020.1

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    複数の脳転移に対する単一アイソセンタVMAT(SIVMAT)の患者セットアップの並進誤差が線量の不確かさに及ぼす影響を評価した。治療計画装置上において、30×30×30cm3の仮想水等価ファントム上で、二つの模擬腫瘍肉眼腫瘍体積(GTV)を作成した。並進誤差が増加するにつれて、各GTVと計画標的体積(PTV)の線量カバレッジは低下し、GTVとPTVの直径が小さい場合、線量カバレッジはより低下した。各GTVおよびPTVの線量カバレッジは、GTVおよびPTVの体積が小さいほど、並進誤差が大きくなるにつれて低下した。GTVの直径が0.5cm、1.0cm、1.5cm、2.0cmの場合、至適PTVマージンはそれぞれ8.6mm、6.1mm、3.6mm、1.0mmであった。また、GTVの体積が1.0cm3、5.0cm3、10.0cm3、14.0cm3の場合、至適PTVマージンはそれぞれ7.0mm、3.4mm、1.8mm、1.0mmであった。1.0mm PTVマージンを設定した場合、PTV線量カバレッジの低下率5%以内を満たすためには、2.0cm以上の直径または14.0cm3以上の体積をもつGTVが必要であった。

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  • 超高リスク前立腺癌に対する内分泌療法併用高線量率組織内照射療法の有効性の検討

    笠原 隆, 山名 一寿, 丸山 亮, 石崎 文雄, 海津 元樹, 青山 英史, 西山 勉, 冨田 善彦

    日本癌治療学会学術集会抄録集   57回   P107 - 1   2019.10

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  • 転移全脳照射後8ヵ月時点までの認知機能とHR-QOL

    中野 智成, 斎藤 紘丈, 棚邊 哲史, 押金 智哉, 太田 篤, 阿部 英輔, 海津 元樹, 青山 英史

    日本癌治療学会学術集会抄録集   57回   P53 - 3   2019.10

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  • The impact of the three degrees-of-freedom fiducial marker-based setup compared to soft tissue-based setup in hypofractionated intensity-modulated radiotherapy for prostate cancer. Reviewed International journal

    Tanabe S, Utsunomiya S, Abe E, Sato H, Ohta A, Sakai H, Yamada T, Kaidu M, Aoyama H

    Journal of applied clinical medical physics   20 ( 6 )   53 - 59   2019.6

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    PURPOSE: We evaluated the setup accuracy of a three-degree-of-freedom fiducial marker (3DOF-FM)-based setup compared to a soft tissue (ST)-based setup in hypofractionated intensity-modulated radiotherapy (IMRT) for prostate cancer. MATERIALS AND METHODS: We analyzed the setup accuracy for 17 consecutive prostate cancer patients with three implanted FMs who underwent hypofractionated IMRT. The 3DOF-ST-based setup using cone-beam computed tomography (CT) was performed after a six DOF-bony structure (BS)-based setup using an ExacTrac x-ray system. The 3DOF-FM-based matching using the ExacTrac x-ray system was done during the BS- and ST-based setups. We determined the mean absolute differences and the correlation between the FM- and ST-based translational shifts relative to the BS-based setup position. The rotational mean shifts detected by the ExacTrac x-ray system were also evaluated. RESULTS: The mean differences in the anterior-posterior (AP), superior-inferior (SI), and left-right (LR) dimensions were 0.69, 0.0, and 0.30 mm, respectively. The Pearson correlation coefficients for both shifts were 0.92 for AP, 0.91 for SI, and 0.68 for LR. The percentages of shift agreements within 2 mm were 85% for AP, 93% for SI, and 99% for LR. The absolute values of rotational shifts were 0.1° for AP, 0.3°, and 1.2° for LR. CONCLUSIONS: The setup accuracy of the 3DOF-FM-based setup has the potential to be interchangeable with a ST-based setup. Our data are likely to be useful in clinical practice along with the popularization of the hypofractionated IMRT in prostate cancer.

    DOI: 10.1002/acm2.12603

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  • 前立腺癌放射線治療後の血中テストステロン値の上昇が治療成績に及ぼす影響

    原 昇, 笠原 隆, 丸山 亮, 山名 一寿, 石崎 文雄, 鳥羽 智貴, 黒木 大生, 海津 元樹, 青山 英史, 冨田 善彦

    日本泌尿器科学会総会   107回   OP - 276   2019.4

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  • Selection criteria for 3D conformal radiotherapy versus volumetric-modulated arc therapy in high-grade glioma based on normal tissue complication probability of brain Reviewed

    Satoshi Tanabe, Haruna Takahashi, Hirotake Saito, Atsushi Ohta, Toshimichi Nakano, Ryuta Sasamoto, Miki Shioi, Satoru Utsunomiya, Eisuke Abe, Motoki Kaidu, Hidefumi Aoyama

    Journal of Radiation Research   60 ( 2 )   249 - 256   2019.3

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    DOI: 10.1093/jrr/rry106

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  • Complementary Relation Between the Improvement of Dose Delivery Technique and PTV Margin Reduction in Dose-Escalated Radiation Therapy for Prostate Cancer. Reviewed International journal

    Utsunomiya S, Yamamoto J, Tanabe S, Oishi M, Satsuma A, Kaidu M, Abe E, Ohta A, Kushima N, Aoyama H

    Practical radiation oncology   9 ( 3 )   172 - 178   2019.2

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    PURPOSE: The purpose of this study is to demonstrate quantitatively the complementary relationship between the introduction of intensity modulated radiation therapy (IMRT) and planning target volume (PTV) margin reduction with an image guided technique in reducing the risk of rectal toxicity in dose-escalating prostate radiation therapy. METHODS AND MATERIALS: Three-dimensional conformal radiation therapy (CRT) and IMRT plans were generated for 10 patients with prostate cancer based on 2 PTV margin protocols (10/8 mm and 6/5 mm) and 2 dose prescriptions (70 Gy and 78 Gy). The normal tissue complication probability (NTCP) for each of the 8 scenarios was calculated using the Lyman-Kutcher-Burman model to estimate the risk of rectal and bladder late toxicity. The conformity and homogeneity indices of PTVs were calculated for each plan. RESULTS: The IMRT plans showed superiority in conformity and inferiority in homogeneity over 3-dimensional CRT plans. The rectal NTCPs were increased 3.5 to 4.1 times when the prescribed total dose was changed from 70 Gy to 78 Gy and the dose delivery and the image guided radiation therapy techniques remained unchanged. PTV margin reduction was shown to reduce the value of rectal NTCP significantly. Overall, implementing the IMRT technique alone could reduce the NTCP values only by 2.1% to 7.3% from those of 3-dimensional CRT. The introduction of both IMRT and PTV margin reduction was found to be necessary for rectal NTCP to remain <5% in the dose escalation from 70 to 78 Gy. CONCLUSIONS: The complementary relationship between the introduction of IMRT and PTV margin reduction was proven. We found that both approaches need to be implemented to safely deliver a curative dose in dose-escalating prostate radiation therapy.

    DOI: 10.1016/j.prro.2019.02.001

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  • 前立腺癌IMRT後のQOL評価

    冨永 理喜, 阿部 英輔, 海津 元樹, 押金 智哉, 丸山 克也, 田中 研介, 中野 智成, 塩井 美希, 齋藤 紘丈, 太田 篤, 青山 英史

    Japanese Journal of Radiology   37 ( Suppl. )   7 - 7   2019.2

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  • Definitive chemoradiotherapy with low-dose continuous 5-fluorouracil reduces hematological toxicity without compromising survival in esophageal squamous cell carcinoma patients. Reviewed

    Saito H, Ohta A, Abe E, Kaidu M, Shioi M, Nakano T, Oshikane T, Tanaka K, Maruyama K, Kushima N, Tanabe S, Utsunomiya S, Sasamoto R, Aoyama H

    Clinical and translational radiation oncology   9   12 - 17   2018.2

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    DOI: 10.1016/j.ctro.2017.12.003

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  • 悪性神経膠腫における寡分割照射を考慮した3DCRT/VMATの正常脳組織障害確率の比較

    高橋 春奈, 棚邊 哲史, 斎藤 紘丈, 中野 智成, 太田 篤, 海津 元樹, 青山 英史, 宇都宮 悟

    Japanese Journal of Radiology   36 ( Suppl. )   8 - 8   2018.2

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  • 前立腺癌に対する高線量率組織内照射 5年経過例の尿道狭窄の検討

    丸山 克也, 海津 元樹, 阿部 英輔, 田中 研介, 太田 篤, 塩井 美希, 斎藤 紘丈, 中野 智成, 青山 英史, 笹本 龍太

    Japanese Journal of Radiology   36 ( Suppl. )   11 - 11   2018.2

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  • 前立腺癌に対する強度変調放射線治療と高線量率組織内照射の治療成績の比較検討

    瀧澤 逸大, 笠原 隆, 丸山 亮, 山名 一寿, 阿部 英輔, 海津 元樹, 青山 英史, 冨田 善彦

    日本癌治療学会学術集会抄録集   55回   P72 - 1   2017.10

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  • Nationwide multi-institutional retrospective analysis of high-dose-rate brachytherapy combined with external beam radiotherapy for localized prostate cancer: An Asian Prostate HDR-BT Consortium Reviewed

    Hiromichi Ishiyama, Nobuhiko Kamitani, Hidemasa Kawamura, Shingo Kato, Manabu Aoki, Shinji Kariya, Taisei Matsumura, Motoki Kaidu, Ken Yoshida, Yaichiro Hashimoto, Yasutaka Noda, Keith H. C. Lim, Takatsugu Kawase, Takeo Takahashi, Koji Inaba, Motoyasu Kumano, Nobuhiko Yoshikawa, Yasuo Yoshioka, Katsumasa Nakamura, Junichi Hiratsuka, Jun Itami, Kazushige Hayakawa

    BRACHYTHERAPY   16 ( 3 )   503 - 510   2017.5

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    PURPOSE: To report outcomes and risk factors of high-dose-rate (HDR) brachytherapy combined with external beam radiotherapy with or without androgen deprivation therapy (ADT) in prostate cancer patients.
    MATERIALS AND METHODS: This multi-institutional retrospective analysis comprised 3424 patients with localized prostate cancer at 16 Asian hospitals. One-thirds (27.7%) of patients received only neoadjuvant ADT, whereas almost half (49.5%) of patients received both neoadjuvant and adjuvant ADT. Mean duration of neoadjuvant and adjuvant ADT were 8.6 months and 27.9 months, respectively. Biochemical failure was defined by Phoenix ASTRO consensus. Biochemical control rate, clinical disease-free survival (cDFS), cause-specific survival, and overall survival (OS) were calculated.
    RESULTS: Median followup was 66 months. Ten-year biochemical control, cDFS, cause-specific survival, and OS rate were 81.4%, 81.0%, 97.2%, and 85.6%, respectively. Receiving both neoadjuvant and adjuvant ADT was detected as a favorable factor for biochemical control, cDFS, and OS, but pelvic irradiation was detected as an adverse factor for cause-specific survival, and OS. Ten-year cumulative rates of late Grade &gt;= 2 genitourinary and gastrointestinal toxicities were 26.8% and 4.1%, respectively; receiving both neoadjuvant and adjuvant ADT was detected as a favorable factor for preventing both toxicities.
    CONCLUSIONS: HDR combined with external beam radiotherapy was an effective and safe treatment for localized prostate cancer. Combination of long-term ADT was suggested to be necessary, even for HDR brachytherapy, and was useful in suppressing late toxicities. Meanwhile, pelvic irradiation was suggested to have an adverse effect on OS of our study population. (C) 2017 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.brachy.2017.01.006

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  • 局所進行性前立腺癌(臨床病期C)に対する、外照射併用高線量率組織内照射の治療成績

    笠原 隆, 山名 一寿, 丸山 亮, 瀧澤 逸大, 海津 元樹, 青山 英史, 西山 勉, 冨田 善彦

    日本泌尿器科学会総会   105回   PP19 - 11   2017.4

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  • Respiratory gating and multifield technique radiotherapy for esophageal cancer Reviewed

    Atsushi Ohta, Motoki Kaidu, Satoshi Tanabe, Satoru Utsunomiya, Ryuta Sasamoto, Katsuya Maruyama, Kensuke Tanaka, Hirotake Saito, Toshimichi Nakano, Miki Shioi, Haruna Takahashi, Naotaka Kushima, Eisuke Abe, Hidefumi Aoyama

    JAPANESE JOURNAL OF RADIOLOGY   35 ( 3 )   95 - 100   2017.3

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    To investigate the effects of a respiratory gating and multifield technique on the dose-volume histogram (DVH) in radiotherapy for esophageal cancer.
    Twenty patients who underwent four-dimensional computed tomography for esophageal cancer were included. We retrospectively created the four treatment plans for each patient, with or without the respiratory gating and multifield technique: No gating-2-field, No gating-4-field, Gating-2-field, and Gating-4-field plans. We compared the DVH parameters of the lung and heart in the No gating-2-field plan with the other three plans.
    In the comparison of the parameters in the No gating-2-field plan, there are significant differences in the Lung V-5Gy, V-20Gy, mean dose with all three plans and the Heart V-25Gy-V-40Gy with Gating-2-field plan, V-35Gy, V-40Gy, mean dose with No Gating-4-field plan and V-30Gy-V-40Gy, and mean dose with Gating-4-field plan. The lung parameters were smaller in the Gating-2-field plan and larger in the No gating-4-field and Gating-4-field plans. The heart parameters were all larger in the No gating-2-field plan.
    The lung parameters were reduced by the respiratory gating technique and increased by the multifield technique. The heart parameters were reduced by both techniques. It is important to select the optimal technique according to the risk of complications.

    DOI: 10.1007/s11604-016-0606-7

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  • 当科での進行食道癌CRT成績の検討

    斎藤 紘丈, 中野 智成, 山名 加菜子, 山名 展子, 棚邊 哲史, 太田 篤, 田中 研介, 丸山 克也, 阿部 英輔, 鮎川 文夫, 宇都宮 悟, 劉 君陽, 海津 元樹, 青山 英史, 笹本 龍太

    Japanese Journal of Radiology   35 ( Suppl. )   4 - 4   2017.2

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  • Two-fraction high-dose-rate brachytherapy within a single day combined with external beam radiotherapy for prostate cancer: single institution experience and outcomes Reviewed

    Junyang Liu, Motoki Kaidu, Ryuta Sasamoto, Fumio Ayukawa, Nobuko Yamana, Hiraku Sato, Kensuke Tanaka, Gen Kawaguchi, Atsushi Ohta, Katsuya Maruyama, Eisuke Abe, Takashi Kasahara, Tsutomu Nishiyama, Yoshihiko Tomita, Hidefumi Aoyama

    JOURNAL OF RADIATION RESEARCH   57 ( 3 )   280 - 287   2016.6

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    We investigated the outcomes of treatment for patients with localized prostate cancer (PCa) treated with 3D conformal radiation therapy (3D-CRT) followed by two-fraction high-dose-rate brachytherapy within a single day (2-fr.-HDR-BT/day) at a single institution. A total of 156 consecutive Asian males (median age, 67 years) were enrolled. To compare our findings with those of other studies, we analyzed our results using the D'Amico classification, assigning the patients to low-(n = 5; 3.2%), intermediate-(n = 36; 23.1%) and high-risk (n = 115; 73.7%) groups (Stage T3 PCa patients were classified as high-risk). One patient in the D'Amico low-risk group (20%), 13 intermediate-risk patients (36.1%) and 99 high-risk patients (86.1%) underwent androgen deprivation therapy. We administered a prescription dose of 39 Gy in 13 fractions of 3D-CRT combined with 18 Gy of HDR-BT in two 9-Gy fractions delivered within a single day. We did not distinguish between risk groups in determining the prescription dose. The median follow-up period was 38 months. Of the 156 patients, one died from primary disease and five died from other diseases. The 3-year overall survival (OS) rates were 100%, 100% and 93.7%, and the 3-year 'biochemical no evidence of disease (bNED)' rates were 100%, 100% and 96.9% for the D'Amico low-, intermediate-and high-risk groups, respectively. No patient developed &gt;= Grade 3 early toxicity. The Grade 3 late genitourinary toxicity rate was 2.6%, and no &gt;= Grade 3 late gastrointestinal toxicity occurred. The efficacy and safety of this study were satisfactory, and longer-term follow-up is necessary.

    DOI: 10.1093/jrr/rrw003

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  • 新潟大学における高リスク前立腺癌に対する高線量率組織内照射の治療経験

    瀧澤 逸大, 笠原 隆, 海津 元樹, 青山 英史, 冨田 善彦

    泌尿器外科   29 ( 臨増 )   900 - 900   2016.5

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  • 食道癌根治照射での血清炎症マーカーに関する検討

    斎藤 紘丈, 鈴木 邦恵, 山名 展子, 棚邉 哲史, 田中 研介, 太田 篤, 佐藤 啓, 丸山 克也, 劉 君陽, 川口 弦, 宇都宮 悟, 鮎川 文夫, 阿部 英輔, 海津 元樹, 青山 英史, 笹本 龍太

    Japanese Journal of Radiology   34 ( Suppl. )   9 - 9   2016.2

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  • G-CSF産生腫瘍が疑われた食道癌の1例

    斎藤 紘丈, 田中 研介, 太田 篤, 佐藤 啓, 丸山 克也, 劉 君陽, 山名 展子, 川口 弦, 鮎川 文夫, 阿部 英輔, 海津 元樹, 青山 英史, 笹本 龍太

    Japanese Journal of Radiology   34 ( Suppl. )   4 - 4   2016.2

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  • 前立腺癌に対する体外照射を併用した高線量率小線源療法 4年間の経験(HIGH-DOSE-RATE BRACHYTHERAPY WITH EXTERNAL BEAM RADIOTHERAPY FOR PROSTATE CANCER: 4-YEAR EXPERIECE)

    劉 君陽, 海津 元樹, 鮎川 文夫, 小日向 美華, 山名 展子, 佐藤 啓, 田中 研介, 川口 弦, 太田 篤, 丸山 克也, 阿部 英輔, 青山 英史, 笹本 龍太

    Japanese Journal of Radiology   34 ( Suppl. )   5 - 5   2016.2

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  • A case of pancreatic neuroendocrine tumors. Reviewed International journal

    Moriyama M, Kaidu M, Aoyama H

    International Cancer Conference Journal   5 ( 1 )   1 - 4   2015.7

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    Pancreatic neuroendocrine tumors (pNETs) are an uncommon malignancy arising from the neuroendocrine cells of pancreas. Most cases of pNETs present with metastatic disease, but there are few reports in the literature describing pNETs metastasis to the lung and mediastinal lymph nodes [1]. Moreover, although a multimodal treatment including surgical resection and chemotherapy is acceptable for management of pNETs, advanced pNETs still remain a difficult therapeutic challenge [2, 3]. Radiotherapy or combined chemoradiotherapy has not been standard in the treatment of pNETs. An 80-year-old female was admitted to our hospital with cough and anorexia. She had been diagnosed and resected pNETs 8 years ago. Mass shadow was pointed out with chest X-ray, and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) was performed. Pathological examination revealed neuroendocrine tumors, so the lung mass was considered as metastasis of pNETs. Then, we discussed her treatment at Cancer Board, and radiotherapy was chosen. We hope this case suggests that radiotherapy will be one of the treatment options for metastatic pNETs.

    DOI: 10.1007/s13691-015-0230-x

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  • The effectiveness of endoscopic submucosal dissection followed by chemoradiotherapy for superficial esophageal cancer Reviewed

    Gen Kawaguchi, Ryuta Sasamoto, Eisuke Abe, Atsushi Ohta, Hiraku Sato, Kensuke Tanaka, Katsuya Maruyama, Motoki Kaizu, Fumio Ayukawa, Nobuko Yamana, Junyang Liu, Manabu Takeuchi, Masaaki Kobayashi, Hidefumi Aoyama

    RADIATION ONCOLOGY   10 ( 1 )   2015.1

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    Background: To evaluate the risks and benefits of endoscopic submucosal dissection (ESD) in addition to chemoradiotherapy (CRT) for the treatment of superficial esophageal squamous cell carcinoma (SESCC).
    Methods and materials: We retrospectively reviewed the treatment outcomes of 47 patients with SESCC treated between October 2000 and December 2011. Sixteen patients with invasion into the submucosal layer (T1b) or the muscularis mucosa (m3) with positive vascular invasion were treated with CRT after ESD (ESD-CRT group). The lymph node area was irradiated to a total dose of 40-44 Gy and a boost radiation was administered if PET-positive lymph nodes or positive margins were observed. The remaining 31 patients received definitive CRT only (dCRT group).
    Results: The radiation field was significantly larger in the ESD-CRT group; the "long T" was used in 11 patients (35.4%) in the dCRT group and 15 (93.7%) in the ESD-CRT group (p = 0.0001). The total radiation dose was smaller in the ESD-CRT group; 40 Gy was used in 10 patients (62.5%) in the ESD-CRT group and all but one patient in the dCRT group received &gt;= 60 Gy (p = 0.00001). The 3-year overall survival rates in the dCRT and ESD-CRT groups were 63.2% and 90.0% respectively (p = 0.118). Recurrence developed in nine patients (29.0%) in the dCRT group and one (6.3%) in the ESD-CRT group. Local recurrence was observed in six patients (19%) in the dCRT group and none in the ESD-CRT-group (p = 0.029). Pericardial effusion (&gt;= Grade 3) occurred in three patients (9.7%) in the dCRT group and none in the ESD-CRT group.
    Conclusions: ESD followed by CRT is an effective and safe approach for SESCC at m3 or T1b. This combination of ESD and CRT improves the local control rate, and it could decrease the number of cardiac toxicities due to a radiation-dose reduction relative to CRT alone.

    DOI: 10.1186/s13014-015-0337-4

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  • Superiority of a soft tissue-based setup using cone-beam computed tomography over a bony structure-based setup in intensity-modulated radiotherapy for prostate cancer Reviewed

    Hiraku Sato, Eisuke Abe, Satoru Utsunomiya, Motoki Kaidu, Nobuko Yamana, Kensuke Tanaka, Atsushi Ohta, Mika Obinata, Junyang Liu, Gen Kawaguchi, Katsuya Maruyama, Fumio Ayukawa, Hidefumi Aoyama

    JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS   16 ( 5 )   239 - 245   2015

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    The purpose of this study was to test the superiority of a soft tissue-based setup using cone-beam computed tomography (CBCT) to a bony structure-based setup using the ExacTrac system in intensity-modulated radiotherapy (IMRT) for prostate cancer. We studied 20 patients with localized prostate cancer who received IMRT between November 2010 and February 2012. After the initial setup, the pelvic bony structure-based setup and ExacTrac system were applied. After that, CBCT and a soft tissue-based setup were used. A shift in the isocenter between the ExacTrac-based and CBCT-based setup was recorded in the anterior-posterior (AP), superior-inferior (SI), and left-right (LR) axes. The shift was considered an interfractional prostate shift. Post-treatment CBCT was also taken once a week to measure the intrafractional prostate shift, based on the coordinates of the isocenter between pre- and post-treatment CBCT. The planning target volume (PTV) margins were determined using van Herk's method. We measured the elapsed time required for soft tissue matching and the entire treatment time using CBCT. The means +/- standard deviation (SD) of the inter-and intrafractional shifts were 0.9 +/- 2.8 mm and -0.3 +/- 1.4 mm in the AP, 0.9 +/- 2.2 mm and -0.1 +/- 1.2 mm in the SI, and 0.1 +/- 0.7 mm and -0.1 +/- 0.7 mm in the LR directions. The PTV margins in the cases of bony structure-based and soft tissue-based setups were 7.3 mm and 2.7 mm in the AP, 5.8 mm and 2.3 mm in the SI, and 1.9 mm and 1.2 mm in the LR directions. Even though the median elapsed time using CBCT was expanded in 5.9 min, the PTV margins were significantly reduced. We found the calculated PTV margins in the soft tissue-based setup using CBCT were small, and this arrangement was superior to the bony structure-based setup in prostate IMRT.

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  • 外照射後の去勢抵抗性前立腺癌に対し高線量率組織内照射が奏功した1例

    鳥羽 智貴, 笠原 隆, 新井 啓, 谷川 俊貴, 西山 勉, 高橋 公太, 海津 元樹, 青山 英史

    日本泌尿器科学会総会   102回   484 - 484   2014.4

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  • 新潟大学病院における前立腺癌高線量率組織内照射治療の経験

    笠原 隆, 西山 勉, 谷川 俊貴, 原 昇, 笹本 龍太, 海津 元樹, 鮎川 文夫, 丸山 克也, 青山 英史, 高橋 公太

    日本泌尿器科学会雑誌   104 ( 2 )   352 - 352   2013.3

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  • 子宮頸癌の放射線治療

    鮎川 文夫, 海津 元樹, 阿部 英輔, 笹本 龍太, 土田 恵美子, 杉田 公, 松本 康男, 伊藤 猛, 青山 英史

    日本医学放射線学会学術集会抄録集   72回   S295 - S295   2013.2

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  • 新潟大学における、前立腺癌高線量率組織内照射療法の初期治療経験

    笠原 隆, 西山 勉, 笹本 龍太, 海津 元樹, 丸山 克也, 小日向 美華, 青山 英史, 高橋 公太

    泌尿器外科   25 ( 8 )   1663 - 1666   2012.8

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    当院では、2009年より前立腺癌に対する放射線外照射併用による高線量率組織内照射療法(HDRBT)を開始した。初期経験(58例)における治療成績およびQOLの変化について検討した。周術期合併症(grade 2)が8例で認められた。追跡期間中央値20ヵ月にて、再発は1例のみであった。QOLに関しては、包括的尺度の一部および排尿機能においてHDRBT施行後早期より有意に低下したが、いずれも時間経過とともに改善する傾向が認められた。(著者抄録)

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  • 限局期前立腺癌に対する外照射併用高線量率組織内照射の初期経験

    丸山 克也, 笹本 龍太, 川口 弦, 福田 貴徳, 阿部 英輔, 海津 元樹, 青山 英史, 笠原 隆, 西山 勉, 高橋 公太

    Japanese Journal of Radiology   30 ( Suppl.I )   6 - 6   2012.2

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  • 前立腺癌高線量率組織内照射療法における急性期有害事象の検討

    海津 元樹, 丸山 克也, 小日向 美華, 山名 展子, 佐藤 啓, 田中 研介, 阿部 英輔, 笹本 龍太, 青山 英史

    日本医学放射線学会学術集会抄録集   71回   S289 - S289   2012.2

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  • 食道癌に対する多門照射と対向2門照射の肺線量に関する比較検討

    笹本 龍太, 阿部 英輔, 福田 貴徳, 川口 弦, 丸山 克也, 海津 元樹, 青山 英史

    日本食道学会学術集会プログラム・抄録集   65回   238 - 238   2011.9

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  • PP-871 外照射併用による高線量率組織内照射療法を受けた前立腺癌患者における、有害事象および健康関連QOLについての検討(発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)

    笠原 隆, 西山 勉, 笹本 龍太, 丸山 克也, 海津 元樹, 青山 英史, 高橋 公太

    日本泌尿器科学会雑誌   102 ( 2 )   550 - 550   2011

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    DOI: 10.5980/jpnjurol.102.550_3

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  • Diagnostic limitations of 10 mm thickness single-slice computed tomography for patients with suspected appendicitis Reviewed

    Motoki Kaidu, Manabu Oyamatu, Kenji Sato, Akira Saitou, Satoshi Yamamoto, Norihiko Yoshimura, Keisuke Sasai

    Radiation Medicine - Medical Imaging and Radiation Oncology   26 ( 2 )   63 - 69   2008.2

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    Purpose. The aim of this retrospective analysis was to evaluate the accuracy of 10 mm thickness single helical computed tomography (CT) examination for confirming the diagnosis of appendicitis or providing a diagnosis other than appendicitis, including underlying periappendical neoplasms. Materials and methods. From April 1, 2001 to March 30, 2005, a total of 272 patients with suspected appendicitis underwent CT examinations. Of the 272 patients, 106 (39%) underwent surgery. Seven CT examinations for seven patients were excluded because of inconsistency of the CT protocol. We therefore reviewed 99 CT images (99 patients) with correlation to surgical-pathological findings to clarify the diagnostic accuracy of CT examinations. We compared the postoperative diagnosis with the preoperative CT report. The final diagnoses were confirmed by macroscopic findings at surgery and pathological evaluations if necessary. Results. Of the 99 patients, 87 had acute appendicitis at surgery. The sensitivity, specificity, and accuracy of CT were 98.9%, 75.0%, and 96.0%, respectively. The positive predictive value and negative predictive value were 96.6% and 90.0%, respectively. Among nine patients in the true-negative category, five had colon cancers
    and among three patients in the false-positive category, two had cancer of the cecal-appendiceal region as the underlying disease. Conclusion. CT examination is useful for patients with suspected appendicitis, but radiologists should be aware of the limitation of thick-sliced single helical CT. They should also be aware of the possibility of other diseases, including coincident abdominal neoplasms and underlying cecal-appendiceal cancer. © 2008 Japan Radiological Society.

    DOI: 10.1007/s11604-007-0196-5

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  • Diagnostic limitations of 10 mm thickness single-slice computed tomography for patients with suspected appendicitis Reviewed

    Motoki Kaidu, Manabu Oyamatu, Kenji Sato, Akira Saitou, Satoshi Yamamoto, Norihiko Yoshimura, Keisuke Sasai

    RADIATION MEDICINE   26 ( 2 )   63 - 69   2008.2

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    Purpose. The aim of this retrospective analysis was to evaluate the accuracy of 10 mm thickness single helical computed tomography (CT) examination for confirming the diagnosis of appendicitis or providing a diagnosis other than appendicitis, including underlying periappendical neoplasms.
    Materials and methods. From April 1, 2001 to March 30, 2005, a total of 272 patients with suspected appendicitis underwent CT examinations. Of the 272 patients, 106 (39%) underwent surgery. Seven CT examinations for seven patients were excluded because of inconsistency of the CT protocol. We therefore reviewed 99 CT images (99 patients) with correlation to surgical-pathological findings to clarify the diagnostic accuracy of CT examinations. We compared the postoperative diagnosis with the preoperative CT report. The final diagnoses were confirmed by macroscopic findings at surgery and pathological evaluations if necessary.
    Results. Of the 99 patients, 87 had acute appendicitis at surgery. The sensitivity, specificity, and accuracy of CT were 98.9%, 75.0%, and 96.0%, respectively. The positive predictive value and negative predictive value were 96.6% and 90.0%, respectively. Among nine patients in the true-negative category, five had colon cancers; and among three patients in the false-positive category, two had cancer of the cecal-appendiceal region as the underlying disease.
    Conclusion. CT examination is useful for patients with suspected appendicitis, but radiologists should be aware of the limitation of thick-sliced single helical CT. They should also be aware of the possibility of other diseases, including coincident abdominal neoplasms and underlying cecal-appendiceal cancer.

    DOI: 10.1007/s11604-007-0196

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  • Distance Education Issue and Challenges Telemedicine and Distance Education in The Medical Field in Japan

    Kouhei Akazawa, Motoki Kaidu

    Nova Science Publisher, Inc.   2007

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  • Development and evaluation of a teleradiology and videoconferencing system. Reviewed

    Motoki Kaidu, Shin-ichi Toyabe, Jun-ichi Oda, Keiske Sasai, Kouhei Akazawa

    Journal of Telemedicine and Telecare   10 ( 4 )   214 - 218   2004.10

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    We developed a teleradiology system linking a general hospital on Sado Island to tertiary care hospitals in Niigata City. The island is 40 km from Niigata City on the mainland and has only one diagnostic radiologist (for 72,000 islanders). Fibre optic cables between Sado Island and Niigata City were used for transmission. The introduction of the teleradiology system facilitated diagnostic and therapeutic consultation with specialists in Niigata City. The performance of the system was evaluated (on a scale of 0-6, with higher scores indicating better performance) by five diagnostic radiologists, who rated 32 features of the system twice, once in April 2002 and once in September 2003. The performance ratings improved from 1.38 to 2.86. While many of the initial problems with the software had been resolved, many still remained.

    DOI: 10.1258/1357633041424430

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  • Development and evaluation of a teleradiology and videoconferencing system. Reviewed

    Kaidu M, Toyabe S, Oda J, Okamoto K, Ozaki T, Shiina M, Sasai K, Akazawa K

    Journal of telemedicine and telecare   10 ( 4 )   214 - 218   2004

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  • 当院の前立腺癌照射法別治療成績の各リスク分類・因子における比較検討 外照射併用HDR-BT vs. IMRT単独

    押金 智哉, 海津 元樹, 阿部 英輔, 丸山 克也, 太田 篤, 斎藤 紘丈, 中野 智成, 後藤 侑世, 青山 英史, 棚邊 哲史, 宇都宮 悟, 笹本 龍太

    臨床放射線   64 ( 6 )   831 - 840   2019.5

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    当院における前立腺癌の放射線治療成績を三次元原体照射(3D-CRT)併用高線量率組織内照射(HDR-BT)と強度変調放射線治療(IMRT)について遡及的にまとめ、各リスク分類やリスク因子別に検討し、どのような症例が3D-CRT併用HDR-BTの良い適応となるのかを探索した。HDR-BTまたはIMRTを施行した前立腺癌の初発根治治療目的の連続症例を対象とした。症例の内訳はHDR-BT 230例、IMRT 140例である。HDR-BT群とIMRT群における5年時点での全生存率、生化学的非再発生存率、局所制御率は各94.7%/95.2%、95.2%/93.7%、98.4%/95.2%であり、両群間に有意差はなかった。CAPRA分類が高リスクの症例ではHDR-BTの局所制御率がIMRTよりも有意に高く、CAPRA中リスクの症例では全生存率、生化学的非再発生存率、局所制御率に有意差はなかった。D'Amico分類での高リスク症例、NCCN分類での高リスク以上の症例でも、両者には有意差がなかった。このほか、年齢、Tステージ、グリソンスコア、PSA、生検陽性本数で解析を行った結果、両群の差が統計学的有意となる因子は5年時点では見いだせなかった。

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J01565&link_issn=&doc_id=20190531180011&doc_link_id=10.18888%2Frp.0000000891&url=https%3A%2F%2Fdoi.org%2F10.18888%2Frp.0000000891&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  • 悪性神経膠腫のVMAT治療計画における2つの線量計算アルゴリズム Analytic Anisotropic AlgorithmとAcuros XBの違いが線量分布へ与える影響

    滝澤 健司, 棚邊 哲史, 宇都宮 悟, 久島 尚隆, 中野 永, 太田 篤, 斎藤 紘丈, 中野 智成, 阿部 英輔, 海津 元樹, 青山 英史

    定位的放射線治療   23   43 - 54   2019.1

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    悪性神経膠腫に対する強度変調回転放射線治療(VMAT)の治療計画におけるAnalytical Anisotropic Algorithm(AAA)とAcuros XB(AXB)の線量分布の違いを明らかにし、AXBの臨床的意義を明らかにすることを目的とした。悪性神経膠腫に対してVMATが施行された連続16症例を対象とした。計画標的体積(PTV)60のD95%およびV95%はAXB治療計画の方が有意に低く、各々効果量は大きかった。CTV60のD95%およびV95%は各々AXB治療計画の方が有意に低く、D95%の効果量は中等度で、V95%の効果量は小さかった。PTV60_skullのD95%およびV95%はAXB治療計画の方が有意に低く、各々効果量は大きかった。一方、PTV60_airについては、D95%はAXB治療計画の方が有意に高かったが、V95%の有意差は認められず、各々効果量は小さかった。また、頭蓋骨体積とPTV60、PTV50の各々の線量差に対する相関係数は0.66、0.71と高い正の相関が認められ、PTV内の頭蓋骨体積の割合が大きいほど線量差は大きくなった。

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  • 前立腺癌放射線治療後の血中テストステロン値の上昇が治療成績に及ぼす影響

    原昇, 笠原隆, 丸山亮, 山名一寿, 石崎文雄, 鳥羽智貴, 黒木大生, 海津元樹, 青山英史, 冨田善彦

    日本泌尿器科学会総会(Web)   107th   2019

  • 悪性神経膠腫における正常脳の正常組織障害発生確率を用いた強度変調回転放射線療法の適応基準の検討

    高橋春奈, 棚邊哲史, 斎藤紘丈, 太田篤, 中野智成, 笹本龍太, 宇都宮悟, 阿部英輔, 海津元樹, 青山英史

    定位放射線治療22   22   125 - 133   2018

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    Language:Japanese   Publisher:日本定位放射線治療学会  

    悪性神経膠腫において強度変調回転放射線療法(VMAT)がより有効である症例の選別基準の方法を構築することを目的として、VMATと三次元原体照射法(3DCRT)の治療計画を放射線誘発性脳壊死のリスク指標とした正常組織障害発生確率(NTCP)を用いて比較した。3DCRTで放射線治療が施行された20例を対象とした。PTVinitialについては、Conformity index(CI)に関してVMATが3DCRTよりも有意に向上しており、PTVboostについてもCIはVMATが有意に向上した。正常脳の平均線量については両治療計画間に有意差は認められなかった。3DCRTにおける正常脳のNTCP 5%未満の群においては、3DCRTとVMATのNTCPの中央値は各々1.2%、0.8%であり有意差は認められなかった。しかし、3DCRTにおける正常脳NTCP 5%以上の群においてはそれぞれ9.6%、4.0%であり、VMATで有意に減少した。また、肉眼的標的体積はNTCP 5%以上の群で大きく、カットオフ値は130.5ccであった。

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  • Examination of acute toxicities after high dose rate (HDR) radiationtherapy for localized prostatic cancer

    58 ( 5 )   717 - 723   2013.5

Presentations

  • Salvage High Dose Rate Brachytherapy for Locally Recurrent Prostatic Cancer After Radiation Therapy. International conference

    Kaidu M, Tanaka K, Nakano T, Maruyama K, Saito H, Shioi M, Utunomiya S, Tanabe S, Takahashi H, Ohta A, Abe E, Sasamoto R, Aoyama H

    American Society for Radiation Oncology  2017.9 

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    Language:English   Presentation type:Poster presentation  

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  • High-Dose-Rate Brachytherapy in Which Two Fractions Were Administered within a Single Day Combined with External Beam Radiotherapy for Prostate Cancer: 4-year Experience and Outcomes Invited International conference

    Kaidu M, Liu J, Sasamoto R, Ayukawa F, Yamana N, Tanaka K, Kawaguchi G, Ohta A, Maruyama K, Saito H, Nakano T, Abe E, Aoyama H

    American Society for Radiation Oncology  2016.9 

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    Language:English   Presentation type:Poster presentation  

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  • DVH-based Comparison Analyses of PTV-coverage and Doses to Organs at Risk (OARs) between Localized Cancers of Large and Regular Volume Prostate Treated with High Dose Rate Brachytherapy (HDR-BT) International conference

    Kaidu M, Ayukawa F, Tanaka K, Obinata M, Sato H, Yamana N, Kawaguchi G, Oota A, Abe E, Sasamoto R, Aoyama H

    Radiation Society of North America  2013.12 

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    Language:English   Presentation type:Oral presentation (general)  

    Venue:Chicago  

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Research Projects

  • 前立腺癌に対する高線量率組織内照射

    2009.8

    System name:放射線医学重点研究

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    Grant type:Competitive

    強度変調放射線治療と比較した治療成績の優劣因子

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