2021/12/04 更新

写真a

カイヅ モトキ
海津 元樹
KAIZU Motoki
所属
医歯学総合病院 放射線治療科 講師
職名
講師
通称等の別名
海津 元樹
外部リンク

学位

  • 医学博士(医学) ( 2008年9月   新潟大学 )

研究分野

  • ライフサイエンス / 放射線科学  / 放射線治療

経歴(researchmap)

  • 新潟大学   医歯学総合病院 放射線治療科   講師

    2015年4月 - 現在

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  • 新潟大学   医歯学総合病院 放射線部   助教

    2012年5月 - 2015年3月

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  • 新潟大学   医歯学総合病院 放射線科   特任助教

    2010年10月 - 2012年4月

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経歴

  • 新潟大学   医歯学総合病院 放射線治療科   講師

    2015年4月 - 現在

  • 新潟大学   医歯学総合病院 放射線部   助教

    2012年5月 - 2015年3月

  • 新潟大学   放射線科   特任助教

    2010年10月 - 2012年4月

取得資格

  • 医師

 

論文

  • Radiobiological evaluation considering setup error on single‐isocenter irradiation in stereotactic radiosurgery

    Hisashi Nakano, Satoshi Tanabe, Ryuta Sasamoto, Takeshi Takizawa, Satoru Utsunomiya, Madoka Sakai, Toshimichi Nakano, Atsushi Ohta, Motoki Kaidu, Hiroyuki Ishikawa

    Journal of Applied Clinical Medical Physics   2021年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1002/acm2.13322

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    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/acm2.13322

  • A comparative study of high-dose-rate brachytherapy boost combined with external beam radiation therapy versus external beam radiation therapy alone for high-risk prostate cancer

    Tomoya Oshikane, Motoki Kaidu, Eisuke Abe, Atsushi Ohta, Hirotake Saito, Toshimichi Nakano, Moe Honda, Satoshi Tanabe, Satoru Utsunomiya, Ryuta Sasamoto, Fumio Ishizaki, Takashi Kasahara, Tsutomu Nishiyama, Yoshihiko Tomita, Hidefumi Aoyama, Hiroyuki Ishikawa

    Journal of Radiation Research   62 ( 3 )   525 - 532   2021年5月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    <title>Abstract</title>
    We aimed to compare the outcomes of high-dose-rate brachytherapy (HDR-BT) boost and external beam radiation therapy (EBRT) alone for high-risk prostate cancer. This was a single-center, retrospective and observational study. Consecutive patients who underwent initial radical treatment by HDR-BT boost or EBRT alone from June 2009 to May 2016 at the Niigata University Medical and Dental Hospital, Japan were included. A total of 96 patients underwent HDR-BT boost, and 61 underwent EBRT alone. The prescription dose of HDR-BT boost was set to 18 Gy twice a day with EBRT 39 Gy/13 fractions. The dose for EBRT alone was mostly 70 Gy/28 fractions. The high-risk group received &amp;gt;6 months of prior androgen deprivation therapy. Overall survival, biochemical-free survival, local control and distant metastasis-free survival rates at 5 years were analyzed. The incidence of urological and gastrointestinal late adverse events of Grade 2 and above was also summarized. In the National Comprehensive Cancer Network (NCCN) high-risk calssification, HDR-BT boost had a significantly higher biochemical-free survival rate at 5 years (98.9% versus 90.7%, P = 0.04). Urethral strictures were more common in the HDR-BT boost group. We will continuously observe the progress of the study patients and determine the longer term results.

    DOI: 10.1093/jrr/rrab006

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  • Detecting MLC modeling errors using radiomics‐based machine learning in patient‐specific QA with an EPID for intensity‐modulated radiation therapy

    Madoka Sakai, Hisashi Nakano, Daisuke Kawahara, Satoshi Tanabe, Takeshi Takizawa, Akihiro Narita, Takumi Yamada, Hironori Sakai, Masataka Ueda, Ryuta Sasamoto, Motoki Kaidu, Hidefumi Aoyama, Hiroyuki Ishikawa, Satoru Utsunomiya

    Medical Physics   48 ( 3 )   991 - 1002   2021年3月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1002/mp.14699

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    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/mp.14699

  • Maximum distance in single-isocenter technique of stereotactic radiosurgery with rotational error using margin-based analysis

    Hisashi Nakano, Satoshi Tanabe, Takumi Yamada, Satoru Utsunomiya, Takeshi Takizawa, Madoka Sakai, Ryuta Sasamoto, Hironori Sakai, Toshimichi Nakano, Hirotake Saito, Atsushi Ohta, Motoki Kaidu, Hiroyuki Ishikawa

    Radiological Physics and Technology   14 ( 1 )   57 - 63   2021年3月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/s12194-020-00602-2

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    その他リンク: http://link.springer.com/article/10.1007/s12194-020-00602-2/fulltext.html

  • Calculated relative biological effectiveness (RBE) for initial DNA double-strand breaks (DSB) from flattening filter and flattening filter-free 6 MV X-ray fields

    Hisashi Nakano, Daisuke Kawahara, Satoshi Tanabe, Satoru Utsunomiya, Takeshi Takizawa, Madoka Sakai, Toshimichi Nakano, Atsushi Ohta, Motoki Kaidu, Hiroyuki Ishikawa

    BJR|Open   3 ( 1 )   20200072 - 20200072   2021年1月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:British Institute of Radiology  

    <sec><title>Objectives:</title> We evaluated the radiobiological effectiveness based on the yields of DNA double-strand breaks (DSBs) of field induction with flattening filter (FF) and FF-free (FFF) photon beams.

    </sec><sec><title>Methods:</title> We used the particle and heavy ion transport system (PHITS) and a water equivalent phantom (30 × 30 × 30 cm<sup>3</sup>) to calculate the physical qualities of the dose-mean lineal energy (y<sub>D</sub>) with 6 MV FF and FFF. The relative biological effectiveness based on the yields of DNA-DSBs (RBE<sub>DSB</sub>) was calculated for standard radiation such as 220 kVp X-rays by using the estimating yields of SSBs and DSBs. The measurement points used to calculate the in-field y<sub>D</sub> and RBE<sub>DSB</sub> were located at a depth of 3, 5, and 10 cm in the water equivalent phantom on the central axis. Measurement points at 6, 8, and 10 cm in the lateral direction of each of the three depths from the central axis were set to calculate the out-of-field y<sub>D</sub> and RBE<sub>DSB</sub>.

    </sec><sec><title>Results:</title> The RBE<sub>DSB</sub> of FFF in-field was 1.7% higher than FF at each measurement depth. The RBE<sub>DSB</sub> of FFF out-of-field was 1.9 to 6.4% higher than FF at each depth measurement point. As the distance to out-of-field increased, the RBE<sub>DSB</sub> of FFF rose higher than those of FF. FFF has a larger RBE<sub>DSB</sub> than FF based on the yields of DNA-DSBs as the distance to out-of-field increased.

    </sec><sec><title>Conclusions:</title> The out-of-field radiobiological effect of FFF could thus be greater than that of FF since the spreading of the radiation dose out-of-field with FFF could be a concern compared to the FF.

    </sec><sec><title>Advances in knowledge:</title> The RBE<sub>DSB</sub> of FFF of out-of-field might be larger than FF.

    </sec>

    DOI: 10.1259/bjro.20200072

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  • Effect of setup error in the single‐isocenter technique on stereotactic radiosurgery for multiple brain metastases

    Hisashi Nakano, Satoshi Tanabe, Satoru Utsunomiya, Takumi Yamada, Ryuta Sasamoto, Toshimichi Nakano, Hirotake Saito, Takeshi Takizawa, Hironori Sakai, Atsushi Ohta, Eisuke Abe, Motoki Kaidu, Hidefumi Aoyama

    Journal of Applied Clinical Medical Physics   21 ( 12 )   155 - 165   2020年12月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1002/acm2.13081

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    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/acm2.13081

  • Radiobiological effects of the interruption time with Monte Carlo Simulation on multiple fields in photon beams

    Hisashi Nakano, Daisuke Kawahara, Satoshi Tanabe, Satoru Utsunomiya, Takeshi Takizawa, Madoka Sakai, Hirotake Saito, Atsushi Ohta, Motoki Kaidu, Hiroyuki Ishikawa

    Journal of Applied Clinical Medical Physics   21 ( 12 )   288 - 294   2020年12月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1002/acm2.13110

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    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/acm2.13110

  • Efficacy and Safety of the Radiotherapy for Liver Cancer: Assessment of Local Controllability and its Role in Multidisciplinary Therapy. 国際誌

    Marina Ohkoshi-Yamada, Kenya Kamimura, Osamu Shibata, Shinichi Morita, Motoki Kaidu, Toshimichi Nakano, Katsuya Maruyama, Atsushi Ota, Hirotake Saito, Nobuko Yamana, Tomoya Oshikane, Yukiyo Goto, Natsumi Yoshimura, Satoshi Tanabe, Hisashi Nakano, Madoka Sakai, Yuto Tanaka, Yohei Koseki, Yoshihisa Arao, Hiroyuki Abe, Toru Setsu, Akira Sakamaki, Takeshi Yokoo, Hiroteru Kamimura, Hidefumi Aoyama, Shuji Terai

    Cancers   12 ( 10 )   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    This study investigated the efficacy and safety of radiotherapy as part of multidisciplinary therapy for advanced hepatocellular carcinoma (HCC). Clinical data of 49 HCC patients treated with radiotherapy were assessed retrospectively. The efficacy of radiotherapy was assessed by progression-free survival, disease control rate, and overall survival. Safety was assessed by symptoms and hematological assay, and changes in hepatic reserve function were determined by Child-Pugh score and albumin-bilirubin (ALBI) score. Forty patients underwent curative radiotherapy, and nine patients with portal vein tumor thrombus (PVTT) underwent palliative radiotherapy as part of multidisciplinary therapy. Local disease control for curative therapy was 80.0% and stereotactic body radiotherapy was 86.7% which was greater than that of conventional radiotherapy (60.0%). Patients with PVTT had a median observation period of 651 days and 75% three-year survival when treated with multitherapy, including radiotherapy for palliative intent, transcatheter arterial chemoembolization, and administration of molecular targeted agents. No adverse events higher than grade 3 and no changes in the Child-Pugh score and ALBI score were seen. Radiotherapy is safe and effective for HCC treatment and can be a part of multidisciplinary therapy.

    DOI: 10.3390/cancers12102955

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  • 高リスク前立腺癌に対する外照射療法併用高線量率組織内照射療法の制癌効果

    笠原 隆, 石崎 文雄, 丸山 亮, 山名 一寿, 海津 元樹, 押金 智哉, 西山 勉, 冨田 善彦

    日本癌治療学会学術集会抄録集   58回   P - 351   2020年10月

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    記述言語:日本語   出版者・発行元:(一社)日本癌治療学会  

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  • High-dose-rate brachytherapy and hypofractionated external beam radiotherapy combined with long-term androgen deprivation therapy for very high-risk prostate cancer. 国際誌

    Takashi Kasahara, Fumio Ishizaki, Akira Kazama, Eri Yuki, Kazutoshi Yamana, Ryo Maruyama, Tomoya Oshikane, Motoki Kaidu, Hidefumi Aoyama, Vladimir Bilim, Tsutomu Nishiyama, Yoshihiko Tomita

    International journal of urology : official journal of the Japanese Urological Association   27 ( 9 )   800 - 806   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To estimate the outcomes of high-dose-rate brachytherapy combined with hypofractionated external beam radiotherapy in prostate cancer patients classified as very high risk by the National Comprehensive Cancer Network. METHODS: Between June 2009 and September 2015, 66 patients meeting the criteria for very high-risk disease received high-dose-rate brachytherapy (2 fractions of 9 Gy) as a boost of external beam radiotherapy (13 fractions of 3 Gy). Androgen deprivation therapy was administered for approximately 3 years. Biochemical failure was assessed using the Phoenix definition. RESULTS: The median follow-up period was 53 months from the completion of radiotherapy. The 5-year biochemical failure-free, distant metastasis-free, prostate cancer-specific and overall survival rates were 88.7, 89.2, 98.5 and 97.0%, respectively. The independent contribution of each component of the very high-risk criteria was assessed in multivariable models. Primary Gleason pattern 5 was associated with increased risks of biochemical failure (P = 0.017) and distant metastasis (P = 0.049), whereas clinical stage ≥T3b or >4 biopsy cores with Gleason score 8-10 had no significant impact on the two outcomes. Grade 3 genitourinary toxicities were observed in two (3.0%) patients, whereas no grade ≥3 gastrointestinal toxicities occurred. CONCLUSIONS: The present study shows that this multimodal approach provides potentially excellent cancer control and acceptable associated morbidity for very high-risk disease. Patients with primary Gleason pattern 5 are at a higher risk of poor outcomes, indicating the need for more aggressive approaches in these cases.

    DOI: 10.1111/iju.14305

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  • High-dose-rate brachytherapy and hypofractionated external beam radiotherapy combined with long-term androgen deprivation therapy for very high-risk prostate cancer

    Takashi Kasahara, Fumio Ishizaki, Akira Kazama, Eri Yuki, Kazutoshi Yamana, Ryo Maruyama, Tomoya Oshikane, Motoki Kaidu, Hidefumi Aoyama, Vladimir Bilim, Tsutomu Nishiyama, Yoshihiko Tomita

    INTERNATIONAL JOURNAL OF UROLOGY   27 ( 9 )   800 - 806   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Objective To estimate the outcomes of high-dose-rate brachytherapy combined with hypofractionated external beam radiotherapy in prostate cancer patients classified as very high risk by the National Comprehensive Cancer Network. Methods Between June 2009 and September 2015, 66 patients meeting the criteria for very high-risk disease received high-dose-rate brachytherapy (2 fractions of 9 Gy) as a boost of external beam radiotherapy (13 fractions of 3 Gy). Androgen deprivation therapy was administered for approximately 3 years. Biochemical failure was assessed using the Phoenix definition. Results The median follow-up period was 53 months from the completion of radiotherapy. The 5-year biochemical failure-free, distant metastasis-free, prostate cancer-specific and overall survival rates were 88.7, 89.2, 98.5 and 97.0%, respectively. The independent contribution of each component of the very high-risk criteria was assessed in multivariable models. Primary Gleason pattern 5 was associated with increased risks of biochemical failure (P = 0.017) and distant metastasis (P = 0.049), whereas clinical stage >= T3b or >4 biopsy cores with Gleason score 8-10 had no significant impact on the two outcomes. Grade 3 genitourinary toxicities were observed in two (3.0%) patients, whereas no grade >= 3 gastrointestinal toxicities occurred. Conclusions The present study shows that this multimodal approach provides potentially excellent cancer control and acceptable associated morbidity for very high-risk disease. Patients with primary Gleason pattern 5 are at a higher risk of poor outcomes, indicating the need for more aggressive approaches in these cases.

    DOI: 10.1111/iju.14305

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  • Dosimetric comparison of analytic anisotropic algorithm and Acuros XB algorithm in VMAT plans for high-grade glioma 査読

    Takeshi Takizawa, Satoshi Tanabe, Satoru Utsunomiya, Hisashi Nakano, Takumi Yamada, Hironori Sakai, Atsushi Ohta, Hirotake Saito, Toshimichi Nakano, Eisuke Abe, Motoki Kaidu, Hidefumi Aoyama

    Physica Medica   73   73 - 82   2020年5月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier {BV}  

    DOI: 10.1016/j.ejmp.2020.04.007

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  • The neurocognitive function change criteria after whole-brain radiation therapy for brain metastasis, in reference to health-related quality of life changes: a prospective observation study. 査読 国際誌

    Toshimichi Nakano, Hidefumi Aoyama, Hirotake Saito, Satoshi Tanabe, Kensuke Tanaka, Katsuya Maruyama, Tomoya Oshikane, Atsushi Ohta, Eisuke Abe, Motoki Kaidu

    BMC cancer   20 ( 1 )   66 - 66   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: We sought to construct the optimal neurocognitive function (NCF) change criteria sensitive to health-related quality of life (HR-QOL) in patients who have undergone whole-brain radiation therapy (WBRT) for brain metastasis. METHODS: We categorized the patients by the changes of NCF into groups of improvement versus deterioration if at least one domain showed changes that exceeded the cut-off while other domains remained stable. The remaining patients were categorized as stable, and the patients who showed both significant improvement and deterioration were categorized as 'both.' We examined the clinical meaning of NCF changes using the cut-off values 1.0, 1.5, and 2.0 SD based on the percentage of patients whose HR-QOL changes were ≥ 10 points. RESULTS: Baseline, 4-month and 8-month data were available in 78, 41 (compliance; 85%), and 29 (81%) patients, respectively. At 4 months, improvement/stable/deterioration/both was seen in 15%/12%/41%/32% of the patients when 1.0 SD was used; 19%/22%/37%/22% with 1.5 SD, and 17%/37%/37%/9% with 2.0 SD. The HR-QOL scores on the QLQ-C30 functional scale were significantly worse in the deterioration group versus the others with 1.0 SD (p = 0.013) and 1.5 SD (p = 0.015). With 1.5 SD, the HR-QOL scores on the QLQ-BN20 was significantly better in the improvement group versus the others (p = 0.033). However, when 'both' was included in 'improvement' or 'deterioration,' no significant difference in HR-QOL was detected. CONCLUSIONS: The NCF cut-off of 1.5 SD and the exclusion of 'both' patients from the 'deterioration' and 'improvement' groups best reflects HR-QOL changes.

    DOI: 10.1186/s12885-020-6559-3

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  • The association between oral candidiasis and severity of chemoradiotherapy-induced dysphagia in head and neck cancer patients: A retrospective cohort study 査読

    Hirotake Saito, Ryusuke Shodo, Keisuke Yamazaki, Kouji Katsura, Yushi Ueki, Toshimichi Nakano, Tomoya Oshikane, Nobuko Yamana, Satoshi Tanabe, Satoru Utsunomiya, Atsushi Ohta, Eisuke Abe, Motoki Kaidu, Ryuta Sasamoto, Hidefumi Aoyama

    Clinical and Translational Radiation Oncology   20   13 - 18   2020年1月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier {BV}  

    DOI: 10.1016/j.ctro.2019.10.006

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  • 多発脳転移に対する単一アイソセンタ照射法における患者セットアップの並進誤差が線量不確かさに及ぼす影響

    中野 永, 棚邊 哲史, 宇都宮 悟, 中野 智成, 斎藤 紘丈, 滝澤 健司, 山田 巧, 坂井 裕則, 太田 篤, 阿部 英輔, 海津 元樹, 青山 英史

    定位的放射線治療   24   81 - 89   2020年1月

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    記述言語:日本語   出版者・発行元:日本定位放射線治療学会  

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  • 超高リスク前立腺癌に対する内分泌療法併用高線量率組織内照射療法の有効性の検討

    笠原 隆, 山名 一寿, 丸山 亮, 石崎 文雄, 海津 元樹, 青山 英史, 西山 勉, 冨田 善彦

    日本癌治療学会学術集会抄録集   57回   P107 - 1   2019年10月

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    記述言語:英語   出版者・発行元:(一社)日本癌治療学会  

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  • The impact of the three degrees-of-freedom fiducial marker-based setup compared to soft tissue-based setup in hypofractionated intensity-modulated radiotherapy for prostate cancer. 査読 国際誌

    Tanabe S, Utsunomiya S, Abe E, Sato H, Ohta A, Sakai H, Yamada T, Kaidu M, Aoyama H

    Journal of applied clinical medical physics   20 ( 6 )   53 - 59   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/acm2.12603

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  • 前立腺癌放射線治療後の血中テストステロン値の上昇が治療成績に及ぼす影響

    原 昇, 笠原 隆, 丸山 亮, 山名 一寿, 石崎 文雄, 鳥羽 智貴, 黒木 大生, 海津 元樹, 青山 英史, 冨田 善彦

    日本泌尿器科学会総会   107回   OP - 276   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本泌尿器科学会総会事務局  

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  • Selection criteria for 3D conformal radiotherapy versus volumetric-modulated arc therapy in high-grade glioma based on normal tissue complication probability of brain 査読

    Satoshi Tanabe, Haruna Takahashi, Hirotake Saito, Atsushi Ohta, Toshimichi Nakano, Ryuta Sasamoto, Miki Shioi, Satoru Utsunomiya, Eisuke Abe, Motoki Kaidu, Hidefumi Aoyama

    Journal of Radiation Research   60 ( 2 )   249 - 256   2019年3月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press ({OUP})  

    DOI: 10.1093/jrr/rry106

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  • Complementary Relation Between the Improvement of Dose Delivery Technique and PTV Margin Reduction in Dose-Escalated Radiation Therapy for Prostate Cancer. 査読 国際誌

    Utsunomiya S, Yamamoto J, Tanabe S, Oishi M, Satsuma A, Kaidu M, Abe E, Ohta A, Kushima N, Aoyama H

    Practical radiation oncology   9 ( 3 )   172 - 178   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.prro.2019.02.001

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  • Definitive chemoradiotherapy with low-dose continuous 5-fluorouracil reduces hematological toxicity without compromising survival in esophageal squamous cell carcinoma patients. 査読

    Saito H, Ohta A, Abe E, Kaidu M, Shioi M, Nakano T, Oshikane T, Tanaka K, Maruyama K, Kushima N, Tanabe S, Utsunomiya S, Sasamoto R, Aoyama H

    Clinical and translational radiation oncology   9   12 - 17   2018年2月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ctro.2017.12.003

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  • 前立腺癌に対する強度変調放射線治療と高線量率組織内照射の治療成績の比較検討

    瀧澤 逸大, 笠原 隆, 丸山 亮, 山名 一寿, 阿部 英輔, 海津 元樹, 青山 英史, 冨田 善彦

    日本癌治療学会学術集会抄録集   55回   P72 - 1   2017年10月

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    記述言語:日本語   出版者・発行元:(一社)日本癌治療学会  

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  • Nationwide multi-institutional retrospective analysis of high-dose-rate brachytherapy combined with external beam radiotherapy for localized prostate cancer: An Asian Prostate HDR-BT Consortium 査読

    Hiromichi Ishiyama, Nobuhiko Kamitani, Hidemasa Kawamura, Shingo Kato, Manabu Aoki, Shinji Kariya, Taisei Matsumura, Motoki Kaidu, Ken Yoshida, Yaichiro Hashimoto, Yasutaka Noda, Keith H. C. Lim, Takatsugu Kawase, Takeo Takahashi, Koji Inaba, Motoyasu Kumano, Nobuhiko Yoshikawa, Yasuo Yoshioka, Katsumasa Nakamura, Junichi Hiratsuka, Jun Itami, Kazushige Hayakawa

    BRACHYTHERAPY   16 ( 3 )   503 - 510   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    PURPOSE: To report outcomes and risk factors of high-dose-rate (HDR) brachytherapy combined with external beam radiotherapy with or without androgen deprivation therapy (ADT) in prostate cancer patients.
    MATERIALS AND METHODS: This multi-institutional retrospective analysis comprised 3424 patients with localized prostate cancer at 16 Asian hospitals. One-thirds (27.7%) of patients received only neoadjuvant ADT, whereas almost half (49.5%) of patients received both neoadjuvant and adjuvant ADT. Mean duration of neoadjuvant and adjuvant ADT were 8.6 months and 27.9 months, respectively. Biochemical failure was defined by Phoenix ASTRO consensus. Biochemical control rate, clinical disease-free survival (cDFS), cause-specific survival, and overall survival (OS) were calculated.
    RESULTS: Median followup was 66 months. Ten-year biochemical control, cDFS, cause-specific survival, and OS rate were 81.4%, 81.0%, 97.2%, and 85.6%, respectively. Receiving both neoadjuvant and adjuvant ADT was detected as a favorable factor for biochemical control, cDFS, and OS, but pelvic irradiation was detected as an adverse factor for cause-specific survival, and OS. Ten-year cumulative rates of late Grade &gt;= 2 genitourinary and gastrointestinal toxicities were 26.8% and 4.1%, respectively; receiving both neoadjuvant and adjuvant ADT was detected as a favorable factor for preventing both toxicities.
    CONCLUSIONS: HDR combined with external beam radiotherapy was an effective and safe treatment for localized prostate cancer. Combination of long-term ADT was suggested to be necessary, even for HDR brachytherapy, and was useful in suppressing late toxicities. Meanwhile, pelvic irradiation was suggested to have an adverse effect on OS of our study population. (C) 2017 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.brachy.2017.01.006

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  • 局所進行性前立腺癌(臨床病期C)に対する、外照射併用高線量率組織内照射の治療成績

    笠原 隆, 山名 一寿, 丸山 亮, 瀧澤 逸大, 海津 元樹, 青山 英史, 西山 勉, 冨田 善彦

    日本泌尿器科学会総会   105回   PP19 - 11   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本泌尿器科学会総会事務局  

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  • Respiratory gating and multifield technique radiotherapy for esophageal cancer 査読

    Atsushi Ohta, Motoki Kaidu, Satoshi Tanabe, Satoru Utsunomiya, Ryuta Sasamoto, Katsuya Maruyama, Kensuke Tanaka, Hirotake Saito, Toshimichi Nakano, Miki Shioi, Haruna Takahashi, Naotaka Kushima, Eisuke Abe, Hidefumi Aoyama

    JAPANESE JOURNAL OF RADIOLOGY   35 ( 3 )   95 - 100   2017年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    To investigate the effects of a respiratory gating and multifield technique on the dose-volume histogram (DVH) in radiotherapy for esophageal cancer.
    Twenty patients who underwent four-dimensional computed tomography for esophageal cancer were included. We retrospectively created the four treatment plans for each patient, with or without the respiratory gating and multifield technique: No gating-2-field, No gating-4-field, Gating-2-field, and Gating-4-field plans. We compared the DVH parameters of the lung and heart in the No gating-2-field plan with the other three plans.
    In the comparison of the parameters in the No gating-2-field plan, there are significant differences in the Lung V-5Gy, V-20Gy, mean dose with all three plans and the Heart V-25Gy-V-40Gy with Gating-2-field plan, V-35Gy, V-40Gy, mean dose with No Gating-4-field plan and V-30Gy-V-40Gy, and mean dose with Gating-4-field plan. The lung parameters were smaller in the Gating-2-field plan and larger in the No gating-4-field and Gating-4-field plans. The heart parameters were all larger in the No gating-2-field plan.
    The lung parameters were reduced by the respiratory gating technique and increased by the multifield technique. The heart parameters were reduced by both techniques. It is important to select the optimal technique according to the risk of complications.

    DOI: 10.1007/s11604-016-0606-7

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  • Two-fraction high-dose-rate brachytherapy within a single day combined with external beam radiotherapy for prostate cancer: single institution experience and outcomes 査読

    Junyang Liu, Motoki Kaidu, Ryuta Sasamoto, Fumio Ayukawa, Nobuko Yamana, Hiraku Sato, Kensuke Tanaka, Gen Kawaguchi, Atsushi Ohta, Katsuya Maruyama, Eisuke Abe, Takashi Kasahara, Tsutomu Nishiyama, Yoshihiko Tomita, Hidefumi Aoyama

    JOURNAL OF RADIATION RESEARCH   57 ( 3 )   280 - 287   2016年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    We investigated the outcomes of treatment for patients with localized prostate cancer (PCa) treated with 3D conformal radiation therapy (3D-CRT) followed by two-fraction high-dose-rate brachytherapy within a single day (2-fr.-HDR-BT/day) at a single institution. A total of 156 consecutive Asian males (median age, 67 years) were enrolled. To compare our findings with those of other studies, we analyzed our results using the D'Amico classification, assigning the patients to low-(n = 5; 3.2%), intermediate-(n = 36; 23.1%) and high-risk (n = 115; 73.7%) groups (Stage T3 PCa patients were classified as high-risk). One patient in the D'Amico low-risk group (20%), 13 intermediate-risk patients (36.1%) and 99 high-risk patients (86.1%) underwent androgen deprivation therapy. We administered a prescription dose of 39 Gy in 13 fractions of 3D-CRT combined with 18 Gy of HDR-BT in two 9-Gy fractions delivered within a single day. We did not distinguish between risk groups in determining the prescription dose. The median follow-up period was 38 months. Of the 156 patients, one died from primary disease and five died from other diseases. The 3-year overall survival (OS) rates were 100%, 100% and 93.7%, and the 3-year 'biochemical no evidence of disease (bNED)' rates were 100%, 100% and 96.9% for the D'Amico low-, intermediate-and high-risk groups, respectively. No patient developed &gt;= Grade 3 early toxicity. The Grade 3 late genitourinary toxicity rate was 2.6%, and no &gt;= Grade 3 late gastrointestinal toxicity occurred. The efficacy and safety of this study were satisfactory, and longer-term follow-up is necessary.

    DOI: 10.1093/jrr/rrw003

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  • 食道癌根治照射での血清炎症マーカーに関する検討

    斎藤 紘丈, 鈴木 邦恵, 山名 展子, 棚邉 哲史, 田中 研介, 太田 篤, 佐藤 啓, 丸山 克也, 劉 君陽, 川口 弦, 宇都宮 悟, 鮎川 文夫, 阿部 英輔, 海津 元樹, 青山 英史, 笹本 龍太

    Japanese Journal of Radiology   34 ( Suppl. )   9 - 9   2016年2月

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    記述言語:日本語   出版者・発行元:(公社)日本医学放射線学会  

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  • A case of pancreatic neuroendocrine tumors. 査読

    Moriyama M, Kaidu M, Aoyama H

    International Cancer Conference Journal   5 ( 1 )   1 - 4   2015年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s13691-015-0230-x

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  • The effectiveness of endoscopic submucosal dissection followed by chemoradiotherapy for superficial esophageal cancer 査読

    Gen Kawaguchi, Ryuta Sasamoto, Eisuke Abe, Atsushi Ohta, Hiraku Sato, Kensuke Tanaka, Katsuya Maruyama, Motoki Kaizu, Fumio Ayukawa, Nobuko Yamana, Junyang Liu, Manabu Takeuchi, Masaaki Kobayashi, Hidefumi Aoyama

    RADIATION ONCOLOGY   10 ( 1 )   2015年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BIOMED CENTRAL LTD  

    Background: To evaluate the risks and benefits of endoscopic submucosal dissection (ESD) in addition to chemoradiotherapy (CRT) for the treatment of superficial esophageal squamous cell carcinoma (SESCC).
    Methods and materials: We retrospectively reviewed the treatment outcomes of 47 patients with SESCC treated between October 2000 and December 2011. Sixteen patients with invasion into the submucosal layer (T1b) or the muscularis mucosa (m3) with positive vascular invasion were treated with CRT after ESD (ESD-CRT group). The lymph node area was irradiated to a total dose of 40-44 Gy and a boost radiation was administered if PET-positive lymph nodes or positive margins were observed. The remaining 31 patients received definitive CRT only (dCRT group).
    Results: The radiation field was significantly larger in the ESD-CRT group; the "long T" was used in 11 patients (35.4%) in the dCRT group and 15 (93.7%) in the ESD-CRT group (p = 0.0001). The total radiation dose was smaller in the ESD-CRT group; 40 Gy was used in 10 patients (62.5%) in the ESD-CRT group and all but one patient in the dCRT group received &gt;= 60 Gy (p = 0.00001). The 3-year overall survival rates in the dCRT and ESD-CRT groups were 63.2% and 90.0% respectively (p = 0.118). Recurrence developed in nine patients (29.0%) in the dCRT group and one (6.3%) in the ESD-CRT group. Local recurrence was observed in six patients (19%) in the dCRT group and none in the ESD-CRT-group (p = 0.029). Pericardial effusion (&gt;= Grade 3) occurred in three patients (9.7%) in the dCRT group and none in the ESD-CRT group.
    Conclusions: ESD followed by CRT is an effective and safe approach for SESCC at m3 or T1b. This combination of ESD and CRT improves the local control rate, and it could decrease the number of cardiac toxicities due to a radiation-dose reduction relative to CRT alone.

    DOI: 10.1186/s13014-015-0337-4

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  • Superiority of a soft tissue-based setup using cone-beam computed tomography over a bony structure-based setup in intensity-modulated radiotherapy for prostate cancer 査読

    Hiraku Sato, Eisuke Abe, Satoru Utsunomiya, Motoki Kaidu, Nobuko Yamana, Kensuke Tanaka, Atsushi Ohta, Mika Obinata, Junyang Liu, Gen Kawaguchi, Katsuya Maruyama, Fumio Ayukawa, Hidefumi Aoyama

    JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS   16 ( 5 )   239 - 245   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MULTIMED INC  

    The purpose of this study was to test the superiority of a soft tissue-based setup using cone-beam computed tomography (CBCT) to a bony structure-based setup using the ExacTrac system in intensity-modulated radiotherapy (IMRT) for prostate cancer. We studied 20 patients with localized prostate cancer who received IMRT between November 2010 and February 2012. After the initial setup, the pelvic bony structure-based setup and ExacTrac system were applied. After that, CBCT and a soft tissue-based setup were used. A shift in the isocenter between the ExacTrac-based and CBCT-based setup was recorded in the anterior-posterior (AP), superior-inferior (SI), and left-right (LR) axes. The shift was considered an interfractional prostate shift. Post-treatment CBCT was also taken once a week to measure the intrafractional prostate shift, based on the coordinates of the isocenter between pre- and post-treatment CBCT. The planning target volume (PTV) margins were determined using van Herk's method. We measured the elapsed time required for soft tissue matching and the entire treatment time using CBCT. The means +/- standard deviation (SD) of the inter-and intrafractional shifts were 0.9 +/- 2.8 mm and -0.3 +/- 1.4 mm in the AP, 0.9 +/- 2.2 mm and -0.1 +/- 1.2 mm in the SI, and 0.1 +/- 0.7 mm and -0.1 +/- 0.7 mm in the LR directions. The PTV margins in the cases of bony structure-based and soft tissue-based setups were 7.3 mm and 2.7 mm in the AP, 5.8 mm and 2.3 mm in the SI, and 1.9 mm and 1.2 mm in the LR directions. Even though the median elapsed time using CBCT was expanded in 5.9 min, the PTV margins were significantly reduced. We found the calculated PTV margins in the soft tissue-based setup using CBCT were small, and this arrangement was superior to the bony structure-based setup in prostate IMRT.

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  • 外照射後の去勢抵抗性前立腺癌に対し高線量率組織内照射が奏功した1例

    鳥羽 智貴, 笠原 隆, 新井 啓, 谷川 俊貴, 西山 勉, 高橋 公太, 海津 元樹, 青山 英史

    日本泌尿器科学会総会   102回   484 - 484   2014年4月

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    記述言語:日本語   出版者・発行元:(一社)日本泌尿器科学会総会事務局  

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  • Diagnostic limitations of 10 mm thickness single-slice computed tomography for patients with suspected appendicitis 査読

    Motoki Kaidu, Manabu Oyamatu, Kenji Sato, Akira Saitou, Satoshi Yamamoto, Norihiko Yoshimura, Keisuke Sasai

    Radiation Medicine - Medical Imaging and Radiation Oncology   26 ( 2 )   63 - 69   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Purpose. The aim of this retrospective analysis was to evaluate the accuracy of 10 mm thickness single helical computed tomography (CT) examination for confirming the diagnosis of appendicitis or providing a diagnosis other than appendicitis, including underlying periappendical neoplasms. Materials and methods. From April 1, 2001 to March 30, 2005, a total of 272 patients with suspected appendicitis underwent CT examinations. Of the 272 patients, 106 (39%) underwent surgery. Seven CT examinations for seven patients were excluded because of inconsistency of the CT protocol. We therefore reviewed 99 CT images (99 patients) with correlation to surgical-pathological findings to clarify the diagnostic accuracy of CT examinations. We compared the postoperative diagnosis with the preoperative CT report. The final diagnoses were confirmed by macroscopic findings at surgery and pathological evaluations if necessary. Results. Of the 99 patients, 87 had acute appendicitis at surgery. The sensitivity, specificity, and accuracy of CT were 98.9%, 75.0%, and 96.0%, respectively. The positive predictive value and negative predictive value were 96.6% and 90.0%, respectively. Among nine patients in the true-negative category, five had colon cancers
    and among three patients in the false-positive category, two had cancer of the cecal-appendiceal region as the underlying disease. Conclusion. CT examination is useful for patients with suspected appendicitis, but radiologists should be aware of the limitation of thick-sliced single helical CT. They should also be aware of the possibility of other diseases, including coincident abdominal neoplasms and underlying cecal-appendiceal cancer. © 2008 Japan Radiological Society.

    DOI: 10.1007/s11604-007-0196-5

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  • Diagnostic limitations of 10 mm thickness single-slice computed tomography for patients with suspected appendicitis 査読

    Motoki Kaidu, Manabu Oyamatu, Kenji Sato, Akira Saitou, Satoshi Yamamoto, Norihiko Yoshimura, Keisuke Sasai

    RADIATION MEDICINE   26 ( 2 )   63 - 69   2008年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Purpose. The aim of this retrospective analysis was to evaluate the accuracy of 10 mm thickness single helical computed tomography (CT) examination for confirming the diagnosis of appendicitis or providing a diagnosis other than appendicitis, including underlying periappendical neoplasms.
    Materials and methods. From April 1, 2001 to March 30, 2005, a total of 272 patients with suspected appendicitis underwent CT examinations. Of the 272 patients, 106 (39%) underwent surgery. Seven CT examinations for seven patients were excluded because of inconsistency of the CT protocol. We therefore reviewed 99 CT images (99 patients) with correlation to surgical-pathological findings to clarify the diagnostic accuracy of CT examinations. We compared the postoperative diagnosis with the preoperative CT report. The final diagnoses were confirmed by macroscopic findings at surgery and pathological evaluations if necessary.
    Results. Of the 99 patients, 87 had acute appendicitis at surgery. The sensitivity, specificity, and accuracy of CT were 98.9%, 75.0%, and 96.0%, respectively. The positive predictive value and negative predictive value were 96.6% and 90.0%, respectively. Among nine patients in the true-negative category, five had colon cancers; and among three patients in the false-positive category, two had cancer of the cecal-appendiceal region as the underlying disease.
    Conclusion. CT examination is useful for patients with suspected appendicitis, but radiologists should be aware of the limitation of thick-sliced single helical CT. They should also be aware of the possibility of other diseases, including coincident abdominal neoplasms and underlying cecal-appendiceal cancer.

    DOI: 10.1007/s11604-007-0196

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  • Distance Education Issue and Challenges Telemedicine and Distance Education in The Medical Field in Japan

    Kouhei Akazawa, Motoki Kaidu

    Nova Science Publisher, Inc.   2007年

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    記述言語:英語   掲載種別:研究論文(大学,研究機関等紀要)   出版者・発行元:Nova Science Publisher, Inc.  

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  • Development and evaluation of a teleradiology and videoconferencing system. 査読

    Motoki Kaidu, Shin-ichi Toyabe, Jun-ichi Oda, Keiske Sasai, Kouhei Akazawa

    Journal of Telemedicine and Telecare   10 ( 4 )   214 - 218   2004年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We developed a teleradiology system linking a general hospital on Sado Island to tertiary care hospitals in Niigata City. The island is 40 km from Niigata City on the mainland and has only one diagnostic radiologist (for 72,000 islanders). Fibre optic cables between Sado Island and Niigata City were used for transmission. The introduction of the teleradiology system facilitated diagnostic and therapeutic consultation with specialists in Niigata City. The performance of the system was evaluated (on a scale of 0-6, with higher scores indicating better performance) by five diagnostic radiologists, who rated 32 features of the system twice, once in April 2002 and once in September 2003. The performance ratings improved from 1.38 to 2.86. While many of the initial problems with the software had been resolved, many still remained.

    DOI: 10.1258/1357633041424430

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  • Development and evaluation of a teleradiology and videoconferencing system. 査読

    Kaidu M, Toyabe S, Oda J, Okamoto K, Ozaki T, Shiina M, Sasai K, Akazawa K

    Journal of telemedicine and telecare   10 ( 4 )   214 - 218   2004年

▶ 全件表示

MISC

  • 当院の前立腺癌照射法別治療成績の各リスク分類・因子における比較検討 外照射併用HDR-BT vs. IMRT単独

    押金 智哉, 海津 元樹, 阿部 英輔, 丸山 克也, 太田 篤, 斎藤 紘丈, 中野 智成, 後藤 侑世, 青山 英史, 棚邊 哲史, 宇都宮 悟, 笹本 龍太

    臨床放射線   64 ( 6 )   831 - 840   2019年5月

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    記述言語:日本語   出版者・発行元:金原出版(株)  

    当院における前立腺癌の放射線治療成績を三次元原体照射(3D-CRT)併用高線量率組織内照射(HDR-BT)と強度変調放射線治療(IMRT)について遡及的にまとめ、各リスク分類やリスク因子別に検討し、どのような症例が3D-CRT併用HDR-BTの良い適応となるのかを探索した。HDR-BTまたはIMRTを施行した前立腺癌の初発根治治療目的の連続症例を対象とした。症例の内訳はHDR-BT 230例、IMRT 140例である。HDR-BT群とIMRT群における5年時点での全生存率、生化学的非再発生存率、局所制御率は各94.7%/95.2%、95.2%/93.7%、98.4%/95.2%であり、両群間に有意差はなかった。CAPRA分類が高リスクの症例ではHDR-BTの局所制御率がIMRTよりも有意に高く、CAPRA中リスクの症例では全生存率、生化学的非再発生存率、局所制御率に有意差はなかった。D'Amico分類での高リスク症例、NCCN分類での高リスク以上の症例でも、両者には有意差がなかった。このほか、年齢、Tステージ、グリソンスコア、PSA、生検陽性本数で解析を行った結果、両群の差が統計学的有意となる因子は5年時点では見いだせなかった。

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  • 悪性神経膠腫のVMAT治療計画における2つの線量計算アルゴリズム Analytic Anisotropic AlgorithmとAcuros XBの違いが線量分布へ与える影響

    滝澤 健司, 棚邊 哲史, 宇都宮 悟, 久島 尚隆, 中野 永, 太田 篤, 斎藤 紘丈, 中野 智成, 阿部 英輔, 海津 元樹, 青山 英史

    定位的放射線治療   23   43 - 54   2019年1月

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    記述言語:日本語   出版者・発行元:日本定位放射線治療学会  

    悪性神経膠腫に対する強度変調回転放射線治療(VMAT)の治療計画におけるAnalytical Anisotropic Algorithm(AAA)とAcuros XB(AXB)の線量分布の違いを明らかにし、AXBの臨床的意義を明らかにすることを目的とした。悪性神経膠腫に対してVMATが施行された連続16症例を対象とした。計画標的体積(PTV)60のD95%およびV95%はAXB治療計画の方が有意に低く、各々効果量は大きかった。CTV60のD95%およびV95%は各々AXB治療計画の方が有意に低く、D95%の効果量は中等度で、V95%の効果量は小さかった。PTV60_skullのD95%およびV95%はAXB治療計画の方が有意に低く、各々効果量は大きかった。一方、PTV60_airについては、D95%はAXB治療計画の方が有意に高かったが、V95%の有意差は認められず、各々効果量は小さかった。また、頭蓋骨体積とPTV60、PTV50の各々の線量差に対する相関係数は0.66、0.71と高い正の相関が認められ、PTV内の頭蓋骨体積の割合が大きいほど線量差は大きくなった。

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  • 前立腺癌放射線治療後の血中テストステロン値の上昇が治療成績に及ぼす影響

    原昇, 笠原隆, 丸山亮, 山名一寿, 石崎文雄, 鳥羽智貴, 黒木大生, 海津元樹, 青山英史, 冨田善彦

    日本泌尿器科学会総会(Web)   107th   2019年

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  • 限局性の前立腺癌に対する高線量率組織内照射療法による急性期有害事象の検討

    海津 元樹, 丸山 克也, 小日向 美華

    臨床放射線   58 ( 5 )   717 - 723   2013年5月

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    記述言語:日本語   出版者・発行元:金原出版  

    CiNii Article

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    その他リンク: http://search.jamas.or.jp/link/ui/2013243329

講演・口頭発表等

  • Salvage High Dose Rate Brachytherapy for Locally Recurrent Prostatic Cancer After Radiation Therapy. 国際会議

    Kaidu M, Tanaka K, Nakano T, Maruyama K, Saito H, Shioi M, Utunomiya S, Tanabe S, Takahashi H, Ohta A, Abe E, Sasamoto R, Aoyama H

    American Society for Radiation Oncology  2017年9月 

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    記述言語:英語   会議種別:ポスター発表  

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  • High-Dose-Rate Brachytherapy in Which Two Fractions Were Administered within a Single Day Combined with External Beam Radiotherapy for Prostate Cancer: 4-year Experience and Outcomes 招待 国際会議

    Kaidu M, Liu J, Sasamoto R, Ayukawa F, Yamana N, Tanaka K, Kawaguchi G, Ohta A, Maruyama K, Saito H, Nakano T, Abe E, Aoyama H

    American Society for Radiation Oncology  2016年9月 

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    記述言語:英語   会議種別:ポスター発表  

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  • DVH-based Comparison Analyses of PTV-coverage and Doses to Organs at Risk (OARs) between Localized Cancers of Large and Regular Volume Prostate Treated with High Dose Rate Brachytherapy (HDR-BT) 国際会議

    Kaidu M, Ayukawa F, Tanaka K, Obinata M, Sato H, Yamana N, Kawaguchi G, Oota A, Abe E, Sasamoto R, Aoyama H

    Radiation Society of North America  2013年12月 

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    記述言語:英語   会議種別:口頭発表(一般)  

    開催地:Chicago  

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