Updated on 2025/01/05

写真a

 
NAGASHIMA Hiroshi
 
Organization
Academic Assembly Institute of Medicine and Dentistry IGAKU KEIRETU Associate Professor
Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Regenerative and Transplant Medicine Associate Professor
Title
Associate Professor
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Degree

  • Ph. D. ( 2005.3   Kobe University )

Research Interests

  • Morphology

  • Embryology

  • Evolutionary developmental biology

  • Experimental developmental biology

Research Areas

  • Life Science / Anatomy

Research History (researchmap)

  • Niigata University Graduate School of Medical and Dental Sciences   Division of Gross Anatomy and Morphogenesis   Associate Professor

    2015.1

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  • Niigata University Graduate School of Medical and Dental Sciences   Division of Gross Anatomy and Morphogenesis   Assistant Professor

    2011.4 - 2014.12

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  • RIKEN, Center for Developmental Biology   Lab. for Evolutionary Developmental Biology   Researcher

    2006.4 - 2011.3

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  • RIKEN, Center for Developmental Biology   Lab. for Evolutionary Developmental Biology   Technical Staff

    2005.4 - 2006.3

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Research History

  • Niigata University   Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Regenerative and Transplant Medicine   Associate Professor

    2015.1

  • Niigata University   Faculty of Medicine School of Medicine   Assistant Professor

    2011.4 - 2014.12

  • Niigata University   Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Regenerative and Transplant Medicine   Assistant Professor

    2011.4 - 2014.12

Professional Memberships

  • THE JAPANESE ASSOCIATION OF ANATOMISTS

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Papers

  • Chondrocranial variation in chicken domestication

    Daniel Núñez‐León, Hiroshi Nagashima, Marcelo R. Sánchez‐Villagra

    Journal of Experimental Zoology Part B: Molecular and Developmental Evolution   338 ( 8 )   505 - 515   2022.10

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    The chondrocranium is a key structure of the skull, but our knowledge of its embryonic development is based mostly on investigations of few stages across taxa. Variation of chondrocranial features is known across species, but little is known about intraspecific variation, or its evolution in the context of domestication. Here, we investigated two specific structures of the chondrocranium in three windows of embryonic development. The anatomy of one of these structures was also compared among adult skulls of chickens and their wild ancestor (red junglefowl [RJF]). The proccesus tectalis and the prenasal process, along with the surrounding area of the orbitonasal foramina, presented variation throughout the ontogeny and in the adults. The processus tectalis showed distinct variation from the earliest stage studied to the adult. The numbers of orbitonasal foramina were also found to be variable in the ancestor and breeds studied. Furthermore, during early embryonic development, the prenasal process is similar across breeds and RJF, but later in embryonic development this structure presents variable states. The embryonic and adult variation found herein could be an example of intraspecific variation under domestication, resulting from different types of tissue interrelationship during development.

    DOI: 10.1002/jez.b.23177

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jez.b.23177

  • Skeletal variation in bird domestication: limb proportions and sternum in chicken, with comparisons to mallard ducks and Muscovy ducks

    Carlos Manuel Herrera-Castillo, Madeleine Geiger, Daniel Núñez-León, Hiroshi Nagashima, Sabine Gebhardt-Henrich, Michael Toscano, Marcelo R. Sanchez-Villagra

    PeerJ   10   e13229 - e13229   2022.4

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    Publishing type:Research paper (scientific journal)   Publisher:PeerJ  

    Background

    Domestication, including selective breeding, can lead to morphological changes of biomechanical relevance. In birds, limb proportions and sternum characteristics are of great importance and have been studied in the past for their relation with flight, terrestrial locomotion and animal welfare. In this work we studied the effects of domestication and breed formation in limb proportions and sternum characteristics in chicken (Gallus gallus), mallard ducks (Anas plathyrhynchos) and Muscovy ducks (Cairina moschata).

    Methods

    First, we quantified the proportional length of three long bones of the forelimb (humerus, radius, and carpometacarpus) and the hind limb (femur, tibiotarsus, and tarsometatarsus) in domestic chickens, mallard ducks, and Muscovy ducks and their wild counterparts. For this, we took linear measurements of these bones and compared their proportions in the wildvs.the domestic group in each species. In chicken, these comparisons could also be conducted among different breeds. We then evaluated the proportional differences in the context of static and ontogenetic allometry. Further, we compared discrete sternum characteristics in red jungle fowl and chicken breeds. In total, we examined limb bones of 287 specimens and keel bones of 63 specimens.

    Results

    We found a lack of significant change in the proportions of limb bones of chicken and Muscovy duck due to domestication, but significant differences in the case of mallard ducks. Variation of evolvability, allometric scaling, and heterochrony may serve to describe some of the patterns of change we report. Flight capacity loss in mallard ducks resulting from domestication may have a relation with the difference in limb proportions. The lack of variation in proportions that could distinguish domestic from wild forms of chicken and Muscovy ducks may reflect no selection for flight capacity during the domestication process in these groups. In chicken, some of the differences identified in the traits discussed are breed-dependent. The study of the sternum revealed that the condition of crooked keel was not unique to domestic chicken, that some sternal characteristics were more frequent in certain chicken breeds than in others, and that overall there were no keel characteristics that are unique for certain chicken breeds. Despite some similar morphological changes identified across species, this study highlights the lack of universal patterns in domestication and breed formation.

    DOI: 10.7717/peerj.13229

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    Other Link: https://peerj.com/articles/13229.xml

  • Development of fin‐innervating motor neurons after peripheral target removal in medaka fish

    Akina Chiba, Kenichi Soma, Keisuke Watanabe, Hiroshi Nagashima, Noboru Sato

    Developmental Neurobiology   81 ( 2 )   110 - 122   2020.12

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    Peripheral targets regulate the development and survival of the nerve centers that serve them, because the elimination of the target normally results in massive death of the developing neurons that innervate it. This widely accepted theory appears to be well supported by developing limbs and their innervation in tetrapods, but it is unclear whether this concept applies to primitive vertebrates that have paired appendages. In this study, we examined the development of spinal motor neurons following pectoral fin bud removal (FBR) in medaka fish. After FBR, motor axons initially extended to the plexus region in a morphologically normal pattern. During the period of fin innervation, motor axons in the FBR‐medaka failed to form the normal brachial plexus and elongated ventrally toward the abdominal region. In the ventral horn that would normally innervate the pectoral fin, however, neurons did not undergo cell death following FBR. There were no differences in the numbers of axons in the ventral roots between the FBR and control sides. Motor neuron markers, RALDH2 and FOXP1, that are expressed in limb‐innervating motor neurons in the lateral motor column in tetrapods, were also expressed in the ventral horns of both the control and FBR sides in medaka fish. These results suggest that, although both tetrapod and medaka motor neurons share the same molecular characteristics for innervating paired appendages, the fates of neurons differ following the removal of their peripheral target. Therefore, the relationship between the peripheral target and its nerve center may be altered among vertebrates.

    DOI: 10.1002/dneu.22799

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/dneu.22799

  • Novel concept for the epaxial/hypaxial boundary based on neuronal development Reviewed International journal

    Hiroshi Nagashima, Daisuke Koga, Satoshi Kusumi, Katsuki Mukaigasa, Hiroyuki Yaginuma, Tatsuo Ushiki, Noboru Sato

    Journal of Anatomy   237 ( 3 )   427 - 438   2020.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Trunk muscles in vertebrates are classified as either dorsal epaxial or ventral hypaxial muscles. Epaxial and hypaxial muscles are defined as muscles innervated by the dorsal and ventral rami of spinal nerves, respectively. Each cluster of spinal motor neurons passing through dorsal rami innervates epaxial muscles, whereas clusters traveling on the ventral rami innervate hypaxial muscles. Herein, we show that some motor neurons exhibiting molecular profiles for epaxial muscles follow a path in the ventral rami. Dorsal deep-shoulder muscles and some body wall muscles are defined as hypaxial due to innervation via the ventral rami, but a part of these ventral rami has the molecular profile of motor neurons that innervate epaxial muscles. Thus, the epaxial and hypaxial boundary cannot be determined simply by the ramification pattern of spinal nerves. We propose that, although muscle innervation occurs via the ventral rami, dorsal deep-shoulder muscles and some body wall muscles represent an intermediate group that lies between epaxial and hypaxial muscles.

    DOI: 10.1111/joa.13219

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/joa.13219

  • Morphological diversity of integumentary traits in fowl domestication: Insights from disparity analysis and embryonic development

    Daniel Núñez‐León, Gabriel Aguirre‐Fernández, Andrea Steiner, Hiroshi Nagashima, Per Jensen, Esther Stoeckli, Richard A. Schneider, Marcelo R. Sánchez‐Villagra

    Developmental Dynamics   248 ( 11 )   1044 - 1058   2019.9

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    The domestication of the fowl resulted in a large diversity of integumental structures in chicken breeds. Several integumental traits have been investigated from a developmental genetics perspective. However, their distribution among breeds and their developmental morphology remain unexplored. We constructed a discrete trait‐breed matrix and conducted a disparity analysis to investigate the variation of these structures in chicken breeds; 20 integumental traits of 72 chicken breeds and the red junglefowl were assessed. The analyses resulted in slight groupings of breed types comparable to standard breed classification based on artificial selection and chicken type use. The red junglefowl groups together with bantams and European breeds. We provide new data on the red junglefowl and four chicken breeds, demonstrating where and when variation arises during embryonic development. We document variation in developmental timing of the egg tooth and feather formation, as well as other kinds of developmental patterning as in the anlagen of different type of combs. Changes in epithelial‐mesenchymal signaling interactions may drive the highly diverse integument in chickens. Experimental and comparative work has revealed that the cranial neural crest mesenchyme mediates its interactions with the overlying epithelium and is the likely source of patterning that generates diversity in integumental structures.

    DOI: 10.1002/dvdy.105

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/dvdy.105

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Books

  • このは, 8巻, 52-53

    長島 寛(カメの不思議な体)

    文一総合出版  2014 

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  • 進化学事典

    長島 寛( Role: Contributor ,  12.3 甲羅の発生とカメの起源)

    共立出版  2012 

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  • 遺伝. 64巻2号, 35-40頁

    長島 寛, 倉谷 滋(カメはどうやって甲羅を作ったのか?)

    エヌ•ティー•エス  2010 

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  • 科学. 79巻11号, 1177-1180頁

    倉谷 滋, 長島 寛( Role: Contributor ,  カメの謎 甲羅はどのようにして獲得されたのか)

    岩波書店  2009 

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MISC

Awards

  • Anatomical Society Journal of Anatomy Best Paper Prize 2020

    2021.5  

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  • Journal of Anatomy Best Paper Prize 2016

    2017.5   Anatomical Society  

    Hiroshi Nagashima

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  • Journal of Anatomy Runner-Up Best Paper Prize 2013

    2014.5   Anatomical Society, UK  

    Hiroshi Nagashima

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  • 奨励賞

    2011.3   日本解剖学会  

    長島 寛

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  • 理化学研究所 研究奨励賞

    2011.3  

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Research Projects

  • 哺乳類特異的構造、横隔膜を進化させた発生機構の解明

    Grant number:21K06751

    2021.4 - 2024.3

    System name:科学研究費助成事業

    Research category:基盤研究(C)

    Awarding organization:日本学術振興会

    長島 寛

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    ヒトの呼吸は胸式呼吸と腹式呼吸がある。肺自体には筋がないから、肺を容れるカゴである胸郭の容積を変えて、間接的に肺を膨らませたり縮ませたりしている。呼気は主に膨らんだ胸郭や肺が元に戻る復元力である弾性収縮力によって行われるが、吸気は胸郭の容積を拡大して行われる。胸式呼吸では肋骨を引き上げて胸郭を広げ、腹式呼吸では胸郭の底に張っている横隔膜を緊張させて底を下げ胸郭を拡大している。安静時には主に腹式呼吸が働いている。この横隔膜は哺乳類で進化した形質であるが、それがどのような発生基盤を元にして進化したのか不明である。横隔膜は頸部で作られるが、まずコントロールとして、横隔膜のないニワトリの頸神経の発生の特徴を明らかにしようと試みた。ニワトリの前肢、後肢の間に肢芽を移植すると、形成された過剰肢には筋と胸神経が侵入するが、頸部に肢芽を移植しても筋は侵入するものの、頸神経は侵入しないことが知られている。この要因を探るため、肢芽と共に様々な組織を頸部に移植したところ、肢芽に隣接する体節を移植した時に過剰肢に頸神経が侵入することが分かった。さらに頸神経の伸長に肢芽領域体節からの栄養因子が必要なのか、あるいは頸神経の伸長を頸部体節が阻害しているのかを確かめるため、頸部に肢芽を移植し同時に頸部体節を除去したところ、過剰肢に頸神経が侵入した。よって頸部体節が過剰肢への軸索侵入を阻害していたのである。しかしながら、前肢部の体節を頸部体節へ入れ替えても前肢に神経線維が入ったので、頸部体節による軸索伸長阻害は頸神経に対してだけ有効なようである。これは正常発生においては頸神経が前肢に誤って侵入するのを頸部体節が防いでいる、換言すれば腕神経叢の頭側端の位置を頸部体節が決定している可能性を示唆していると考えられた。

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  • 比較・実験発生学からさぐる頸部の筋、神経系の進化

    2018.4 - 2020.3

    System name:科学研究費補助金, 基盤研究(C)

    Awarding organization:日本学術振興会

    長島 寛

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    Authorship:Principal investigator  Grant type:Competitive

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  • 頸部およびそれに関わる解剖学的諸構造の比較、実験発生学的解析

    2015.4 - 2018.3

    System name:科学研究費補助金, 基盤研究(C)

    Awarding organization:日本学術振興会

    長島 寛

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    Authorship:Principal investigator  Grant type:Competitive

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  • 脊椎動物頸部の比較解剖学的、比較発生学的解析

    2012.4 - 2015.3

    System name:科学研究費補助金, 基盤研究(C)

    Awarding organization:日本学術振興会

    長島 寛

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    Authorship:Principal investigator  Grant type:Competitive

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  • 四肢に対する新たな考え方の提案

    2012 - 2015

    System name:医学系研究奨励(基礎)

    Awarding organization:武田科学振興財団

    長島 寛

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    Authorship:Principal investigator  Grant type:Competitive

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Teaching Experience

  • 人体の構造と機能I(肉眼解剖学)

    2024
    Institution name:新潟大学

  • 人体の構造と機能II(神経の構造)

    2024
    Institution name:新潟大学

  • 人体の構造と機能II(組織学各論)

    2024
    Institution name:新潟大学

  • 人体の構造と機能I(組織学総論)

    2024
    Institution name:新潟大学

  • 人体の構造と機能I(解剖総論)

    2024
    Institution name:新潟大学