2022/05/26 更新

写真a

アダチ ソウスケ
安達 聡介
ADACHI Sosuke
所属
医歯学総合研究科 特任准教授
職名
特任准教授
外部リンク

学位

  • 博士(医学) ( 2011年3月   新潟大学 )

研究分野

  • ライフサイエンス / 産婦人科学

経歴

  • 新潟大学   医歯学総合研究科   特任准教授

    2022年4月 - 現在

  • 新潟大学   医歯学総合病院 総合周産期母子医療センター   助教

    2014年7月 - 2022年3月

  • 新潟大学   医歯学総合研究科 分子細胞医学専攻 遺伝子制御   助教

    2012年4月 - 2014年6月

  • 新潟大学   医歯学総合病院 産科婦人科   特任助教

    2011年4月 - 2012年3月

 

論文

  • PET/MR imaging for the evaluation of cervical cancer during pregnancy. 国際誌

    Tatsuya Ishiguro, Nobumichi Nishikawa, Shiro Ishii, Kosuke Yoshihara, Kazufumi Haino, Masayuki Yamaguchi, Sosuke Adachi, Takafumi Watanabe, Shu Soeda, Takayuki Enomoto

    BMC pregnancy and childbirth   21 ( 1 )   288 - 288   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Malignancy during pregnancy is increasing, and the most common type of malignancy is uterine cervical cancer. When planning the treatment of cervical cancer, it is important to look for signs of metastasis before surgery, especially metastasis to the lymph nodes. In this report, we assessed the diagnostic value of positron emission tomography/magnetic resonance imaging (PET/MRI) for evaluating cervical cancer propagation before surgery, with a focus on pregnant women. CASE PRESENTATION: 18F Fluorodeoxyglucose (FDG)-PET/MRI was performed in seven pregnant cervical cancer patients (28-34 years old) at 9-18 gestational weeks. In case #5, a second PET/MRI was performed at 24 gestational weeks. Of seven FDG-PET/MRI examination series in six cases (cases #1-6), FDG-PET/MR imaging could detect cervical tumors with abnormal FDG accumulation; these tumors were confirmed with a standardized uptake value max (SUV max) titer of 4.5-16. A second PET/MRI examination in case #5 revealed the same SUV max titer as the first examination. In these six imaging series (cases #1-5), there were no signs of cancer metastasis to the parametrium and lymph nodes. However, in case #6, abnormal FDG accumulation in the left parametrial lymph nodes was also detectable. Pathological examination showed lymph node metastasis in case #6. In case #7, PET/MRI could not detect any abnormal FDG accumulation in the cervix and other sites. Cone biopsy demonstrated only micro-invasive squamous cell carcinoma. After treatment for cervical cancer, all seven patients have had no recurrence of disease within the follow-up period (2.8-5.6 years), and their children have developed appropriately. CONCLUSION: PET/MRI is an effective imaging tool to evaluate cervical cancer progression in pregnancy.

    DOI: 10.1186/s12884-021-03766-w

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  • Risk factors for HPV infection and high-grade cervical disease in sexually active Japanese women. 国際誌

    Manako Yamaguchi, Masayuki Sekine, Sharon J B Hanley, Risa Kudo, Megumi Hara, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Takayuki Enomoto

    Scientific reports   11 ( 1 )   2898 - 2898   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In Japan, recommendations for HPV vaccines were suspended in 2013 due to unfounded safety fears. Although vaccine opponents claim modifying sexual behavior can prevent cervical cancer, no comprehensive data exist on sexual behavior and the risk of high-grade cervical disease in a Japanese population. This study investigates sexual behavior and the risk of HPV infection and cervical disease in 3968 women aged 20-41 yrs undergoing cervical screening between April 2014 and March 2016. Mean age at first intercourse was 18.4 yrs ± 2.8 and 32% of women reported ≥ 6 lifetime sexual partners. In regression analyses, number of partners was a significant risk factor for HPV infection. However, for high-grade disease (CIN2+), when HPV genotype was adjusted for, number of partners was not statistically significant. The greatest risk factor was an HPV16/18 infection (adjusted odds ratio 113.7, 95% CI: 40.8-316.9). In conclusion, we found that having an HPV16/18 infection and not sexual behavior was the most significant risk factor for high grade cervical disease in young Japanese women. These infections can be prevented by a highly effective vaccine and we recommend that the Japanese government resume proactive recommendations for the HPV vaccine immediately.

    DOI: 10.1038/s41598-021-82354-6

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  • Internet Survey of Awareness and Behavior Related to HPV Vaccination in Japan. 国際誌

    Risa Kudo, Masayuki Sekine, Manako Yamaguchi, Megumi Hara, Sharon J B Hanley, Yutaka Ueda, Asami Yagi, Sosuke Adachi, Megumi Kurosawa, Etsuko Miyagi, Takayuki Enomoto

    Vaccines   9 ( 2 )   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Recommendations for HPV vaccines were suspended in 2013 due to unfounded safety fears in Japan. We aimed to clarify the differences between vaccinated and unvaccinated females in their awareness, knowledge, and behaviors toward cervical cancer, HPV vaccination and sex. Questionnaires were administered online to women aged 16 to 20. We conducted investigations for the following: awareness, knowledge, and actions for cervical cancer, HPV vaccination, and sexual activity, as well as items related to participants' social background. The survey in 828 girls revealed three points. The first is that more than half of the surveyed Japanese girls had poor knowledge about cervical cancer screening, HPV, or HPV vaccines. The second is that those in the unvaccinated group had a particularly poor knowledge of the subject and tended to have higher sexual activity. The final is that only 0.5% of the girls experienced changes in awareness about sexual activity after vaccination. In conclusion, this is the first large-scale survey analyzing the association between HPV vaccination and sexual activity in Japanese girls. Not only do unvaccinated girls not benefit from vaccines, but they also tend to engage in high-risk sexual behavior, and thus it is even more important to provide information on the effectiveness of vaccines and the usefulness of cancer screening.

    DOI: 10.3390/vaccines9020087

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  • HPVワクチンの長期的なHPV16型、18型感染予防効果

    黒澤 めぐみ, 関根 正幸, 山口 真奈子, 工藤 梨沙, 安達 聡介, 八木 麻未, 池田 さやか, 上田 豊, 宮城 悦子, 原 めぐみ, ハンリー・シャロン, 榎本 隆之

    日本癌治療学会学術集会抄録集   58回   O15 - 2   2020年10月

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    記述言語:日本語   出版者・発行元:(一社)日本癌治療学会  

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  • Epidemiologic Profile of Type-Specific Human Papillomavirus Infection after Initiation of HPV Vaccination. 国際誌

    Masayuki Sekine, Manako Yamaguchi, Risa Kudo, Sharon J B Hanley, Megumi Hara, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Sayaka Ikeda, Asami Yagi, Takayuki Enomoto

    Vaccines   8 ( 3 )   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Organized human papillomavirus vaccination (OHPV) in Japan was introduced in 2010 for girls aged 12-16 years who were born in 1994 or later. The rate of OHPV coverage was 70-80%. However, after suspension of the government vaccination recommendation, the coverage dramatically decreased. We aim to investigate the change in prevalence of HPV infection after the initiation of HPV vaccination. We recruited females aged 20-21 years attending public cervical cancer screening from 2014 to 2017 fiscal years (April 2014 to March 2018). Residual Pap test specimens were collected for HPV testing. We compared the prevalence of HPV type-specific infection between women registered in 2014 (born in 1993-1994, including the pre-OHPV generation) and registered in 2015-2017 (born in 1994-1997, the OHPV generation). We collected 2379 specimens. The vaccination coverage figures were 30.7%, 86.6%, 88.4% and 93.7% (p < 0.01) from 2014 to 2017, respectively. The prevalence of HPV16/18 infection significantly decreased from 1.3% in 2014 to 0% in 2017 (p = 0.02). The three most prevalent types were HPV52, 16 and 56 in 2014, and HPV52, 58 and 56 in 2015-2017, respectively. HPV16 and 33 infection rates decreased. On the other hand, the HPV58 infection rate was obviously increased after OHPV from 0.3% to 2.1%. Our study demonstrates that the prevalence of HPV16/18 infection dramatically decreased and the profile of type-specific HPV infection was changed after OHPV.

    DOI: 10.3390/vaccines8030425

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  • Japan's Ongoing Crisis on HPV Vaccination. 国際誌

    Masayuki Sekine, Risa Kudo, Manako Yamaguchi, Sharon J B Hanley, Megumi Hara, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Sayaka Ikeda, Asami Yagi, Takayuki Enomoto

    Vaccines   8 ( 3 )   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    : The Japanese government suspended proactive recommendations for the HPV vaccine in June 2013. The suspension is now in its seventh year, despite all the data pointing to the safety of the HPV vaccine. We reported a high vaccine effectiveness in the group of women vaccinated before their first intercourse (93.9%). The prevalence of cross-protected types of HPV 31/45/52 was also lower in the vaccinated group, and the vaccine effectiveness was 67.7%. Furthermore, prevalence of HPV16, 31 and 52 infection rates in the vaccinated group were obviously lower than that in the unvaccinated group, and no one had HPV18 or 45 infection in the vaccinated group. The addition of a cross-protective effect toward HPV types 31/45/52 to HPV types 16/18, which is the direct target of the bivalent HPV vaccine, may possibly prevent around 82% of invasive cervical cancer cases in Japan. With regard to the preventive effect of histological abnormalities, we also reported significant reduction in incidence of cervical intraepithelial neoplasia (CIN)3 or worse. Thus, the efficacy of the vaccine has been demonstrated for precancerous disease, and the diverse symptoms after HPV vaccination are likely functional somatic. For the future of Japanese girls, there is a need to resume the proactive recommendation of HPV vaccination and for immediate action to be taken by the Japanese government.

    DOI: 10.3390/vaccines8030362

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  • 卵巣卵黄嚢腫瘍に対する妊孕性温存治療後、残存卵巣に発症した成熟嚢胞性奇形腫摘出術前に卵子凍結を施行した1例(A case of mature teratoma in the residual ovary after fertility-sparing therapy for ovarian yolk sac tumor managed with oocyte cryopreservation followed by cystectomy)

    茅原 誠, 安達 聡介, 鈴木 久美子, 石黒 竜也, 西川 伸道, 関根 正幸, 荒井 勇樹, 木下 義晶, 榎本 隆之

    Journal of Mammalian Ova Research   37 ( 1 )   43 - 49   2020年7月

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    記述言語:英語   出版者・発行元:(一社)日本卵子学会  

    症例は17歳.10歳時に卵黄嚢腫瘍IIICを発症し,右付属器切除と術後化学療法が施行された.初回治療から7年後,残存左卵巣に16cm大の成熟嚢胞性奇形腫が疑われた.正常卵巣部位は画像診断で非常に小さく明らかでなかった.卵巣腫瘍摘出術を施行した場合,医原性卵巣機能不全の発症を危惧したため,腫瘍摘出前に卵子凍結保存を施行する方針とした.性交歴がない事,経腔・経腹採卵では腫瘍内容液漏出の可能性があったため,予定開腹手術時に同期して採卵する方針とした.黄体期ランダムスタートとして,排卵誘発を施行し,hCGとGnRHアゴニスト併用によるダブルトリガー後に採卵した.計10個のMII卵を回収し,同日凍結保存した.卵巣腫瘍が非常に大きい場合,開腹卵巣腫瘍直視下で超音波ガイド下に採卵することは安全かつ有効である.(著者抄録)

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  • Vaccine Hesitancy HPVワクチン 日本の今と未来

    山口 真奈子, 関根 正幸, 工藤 梨沙, 安達 聡介, 上田 豊, 宮城 悦子, 原 めぐみ, シャロン・ハンリー, 榎本 隆之

    日本小児科学会雑誌   124 ( 2 )   181 - 181   2020年2月

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    記述言語:日本語   出版者・発行元:(公社)日本小児科学会  

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  • Germline and somatic mutations of homologous recombination-associated genes in Japanese ovarian cancer patients. 査読 国際誌

    Kentaro Sugino, Ryo Tamura, Hirofumi Nakaoka, Nozomi Yachida, Manako Yamaguchi, Yutaro Mori, Kaoru Yamawaki, Kazuaki Suda, Tatsuya Ishiguro, Sosuke Adachi, Masanori Isobe, Masayuki Yamaguchi, Katsunori Kashima, Teiichi Motoyama, Ituro Inoue, Kosuke Yoshihara, Takayuki Enomoto

    Scientific reports   9 ( 1 )   17808 - 17808   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We explored the frequency of germline and somatic mutations in homologous recombination (HR)-associated genes in major histological types of ovarian cancer. We performed targeted sequencing to assess germline and somatic mutations of 16 HR-associated genes and 4 mismatch repair (MMR) genes among 207 ovarian cancer patients (50 high-grade serous carcinomas (HGSC), 99 clear cell carcinomas (CCC), 39 endometrioid carcinomas (EC), 13 mucinous carcinomas (MC), and 6 low-grade serous carcinomas (LGSC)). Germline or somatic mutations of HR-associated genes were detected in 44% of HGSC, 28% of CCC, 23% of EC, 16% of MC, and 17% of LGSC patients. The profile of HR-associated gene mutations was remarkably different among each histological type. Germline BRCA1/2 mutations were frequently detected in HGSC and were rarely observed in CCC, EC, and MC patients. ATM somatic mutation was more frequently detected in CCC (9%) and EC patients (18%) than in HGSC patients (4%). There was a positive correlation between MMR gene mutations and HR-associated gene mutations (p = 0.0072). Our findings might be useful in selection of ovarian cancer patients that should be treated with PARP inhibitors.

    DOI: 10.1038/s41598-019-54116-y

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  • 当院でのプラチナ製剤感受性再発卵巣癌に対するオラパリブ投与に関する検討

    西川 伸道, 堀内 綾乃, 春谷 千智, 明石 英彦, 鈴木 美保, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西野 幸治, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   114 ( 1 )   32 - 32   2019年11月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • Different mutation profiles between epithelium and stroma in endometriosis and normal endometrium. 査読 国際誌

    Kazuaki Suda, Hirofumi Nakaoka, Kosuke Yoshihara, Tatsuya Ishiguro, Sosuke Adachi, Hiroaki Kase, Teiichi Motoyama, Ituro Inoue, Takayuki Enomoto

    Human reproduction (Oxford, England)   34 ( 10 )   1899 - 1905   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    STUDY QUESTION: Are there common mutation profiles between epithelial and stromal cells in ovarian endometriotic tissue and the normal endometrium? SUMMARY ANSWER: Our study revealed no common mutations between epithelial and stromal cells in ovarian endometriotic tissue and the normal endometrium. WHAT IS KNOWN ALREADY: Epithelial cells in both ovarian endometriotic tissue and the normal endometrium harbor somatic mutations in cancer-associated genes such as phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and KRAS proto-oncogene, GTPase (KRAS). STUDY DESIGN, SIZE, DURATION: We performed a retrospective study to identify the mutation profiles of stromal cells in endometriotic tissue and the normal endometrium. We collected 11 endometriotic stroma samples and 10 normal endometrial stroma samples between 2013 and 2017 at a tertiary care center. PARTICIPANTS/MATERIALS, SETTING, METHODS: The laser microdissection method was used to obtain stromal cells in ovarian endometriotic and normal endometrial tissues from patients with ovarian endometriosis and/or other non-invasive gynecological diseases. Target gene sequencing was performed to assess and compare the mutation profiles of stromal cells with those of epithelial cells obtained in our previous study. For target gene sequencing, 76 genes were selected based on previous genomic analyses for ovarian endometriosis, normal endometrium, endometriosis-related ovarian cancer and endometrial cancer. MAIN RESULTS AND THE ROLE OF CHANCE: Stromal samples in ovarian endometrioma and normal endometrium harbor somatic mutations (18 mutations in 11 endometriosis samples and 16 mutations in 10 normal endometrial samples) but did not share any mutations with paired epithelial samples. The mutant allele frequency of stromal samples was significantly lower than that of epithelial samples in ovarian endometrioma (P = 6.0 × 10-11) and normal endometrium (P = 1.4 × 10-7). LIMITATIONS, REASONS FOR CAUTION: The number of genes evaluated in the mutational analysis was limited. Additionally, the functional roles of somatic mutations in stromal cells remain unclear. WIDER IMPLICATIONS OF THE FINDINGS: Different mutation profiles between paired epithelial and stromal cells in both ovarian endometrioma and normal endometrium suggest that origins of epithelial and stromal cells would be independent of each other in both normal endometrium and ovarian endometrioma; however, the theory of epithelial-mesenchymal transition is proposed in ovarian endometrioma. STUDY FUNDING/COMPETING INTEREST(S): This work was supported in part by the Japan Society for the Promotion of Science KAKENHI grant number JP15H02373 (Grant-in-Aid for Scientific Research A for I.I.), JP16H06267 (Grant-in-Aid for Young Scientists A for K.Y.), JP17K08688 (Grant-in-Aid for Scientific Research C for H.N.) and JP16H06279 (Grant-in-Aid for Scientific Research on Innovative Areas-Platforms for Advanced Technologies and Research Resources for H.N. and K.Y). There are no conflicts of interest to declare. TRIAL REGISTRATION NUMBER: Not applicable.

    DOI: 10.1093/humrep/dez155

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  • Recurrence, death, and secondary malignancy after ovarian conservation for young women with early-stage low-grade endometrial cancer. 国際誌

    Koji Matsuo, James C Cripe, Katherine C Kurnit, Michiko Kaneda, Audrey S Garneau, Gretchen E Glaser, Aaron Nizam, Rachel M Schillinger, Michelle L Kuznicki, Akira Yabuno, Shiori Yanai, Denise M Garofalo, Jiro Suzuki, Jessica D St Laurent, Ting-Tai Yen, Annie Y Liu, Masako Shida, Mamoru Kakuda, Tetsuro Oishi, Shin Nishio, Jenna Z Marcus, Sosuke Adachi, Tetsuji Kurokawa, Malcolm S Ross, Max P Horowitz, Marian S Johnson, Min K Kim, Alexander Melamed, Karime K Machado, Kosuke Yoshihara, Yoshio Yoshida, Takayuki Enomoto, Kimio Ushijima, Shinya Satoh, Yutaka Ueda, Mikio Mikami, Bobbie J Rimel, Rebecca L Stone, Whitfield B Growdon, Aikou Okamoto, Saketh R Guntupalli, Kosei Hasegawa, Mian M K Shahzad, Dwight D Im, Marina Frimer, Bobbie S Gostout, Frederick R Ueland, Shoji Nagao, Pamela T Soliman, Premal H Thaker, Jason D Wright, Lynda D Roman

    Gynecologic oncology   155 ( 1 )   39 - 50   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To examine the association between ovarian conservation and oncologic outcome in surgically-treated young women with early-stage, low-grade endometrial cancer. METHODS: This multicenter retrospective study examined women aged <50 with stage I grade 1-2 endometrioid endometrial cancer who underwent primary surgery with hysterectomy from 2000 to 2014 (US cohort n = 1196, and Japan cohort n = 495). Recurrence patterns, survival, and the presence of a metachronous secondary malignancy were assessed based on ovarian conservation versus oophorectomy. RESULTS: During the study period, the ovarian conservation rate significantly increased in the US cohort from 5.4% to 16.4% (P = 0.020) whereas the rate was unchanged in the Japan cohort (6.3-8.7%, P = 0.787). In the US cohort, ovarian conservation was not associated with disease-free survival (hazard ratio [HR] 0.829, 95% confidence interval [CI] 0.188-3.663, P = 0.805), overall survival (HR not estimated, P = 0.981), or metachronous secondary malignancy (HR 1.787, 95% CI 0.603-5.295, P = 0.295). In the Japan cohort, ovarian conservation was associated with decreased disease-free survival (HR 5.214, 95% CI 1.557-17.464, P = 0.007) and an increased risk of a metachronous secondary malignancy, particularly ovarian cancer (HR 7.119, 95% CI 1.349-37.554, P = 0.021), but was not associated with overall survival (HR not estimated, P = 0.987). Ovarian recurrence or metachronous secondary ovarian cancer occurred after a median time of 5.9 years, and all cases were salvaged. CONCLUSION: Our study suggests that adoption of ovarian conservation in young women with early-stage low-grade endometrial cancer varies by population. Ovarian conservation for young women with early-stage, low-grade endometrial cancer may be potentially associated with increased risks of ovarian recurrence or metachronous secondary ovarian cancer in certain populations; nevertheless, ovarian conservation did not negatively impact overall survival.

    DOI: 10.1016/j.ygyno.2019.08.007

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  • 日本人女性における性的活動性とHPV感染、子宮頸部組織診異常との関係

    山口 真奈子, 関根 正幸, 工藤 梨沙, 安達 聡介, 上田 豊, 宮城 悦子, 原 めぐみ, Hanley Sharon J.B., 榎本 隆之

    日本癌治療学会学術集会抄録集   57回   O1 - 1   2019年10月

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    記述言語:英語   出版者・発行元:(一社)日本癌治療学会  

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  • Tumor characteristics and outcome of uterine carcinosarcoma in women aged ≥80 years. 査読 国際誌

    Matsuo K, Ross MS, Yunokawa M, Johnson MS, Machida H, Omatsu K, Klobocista MM, Im DD, Satoh S, Baba T, Ikeda Y, Bush SH, Hasegawa K, Blake EA, Takekuma M, Shida M, Nishimura M, Adachi S, Pejovic T, Takeuchi S, Yokoyama T, Ueda Y, Iwasaki K, Miyake TM, Yanai S, Nagano T, Takano T, Shahzad MM, Ueland FR, Kelley JL, Roman LD

    Surgical oncology   29   25 - 32   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.suronc.2019.02.002

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  • Precision medicineクリニカルシークエンスの現状と課題 HBOC診療の連携確立に向けて 新潟県の取り組み

    西野 幸治, 山口 雅幸, 安達 聡介, 吉原 弘祐, 関根 正幸, 榎本 隆之, 須田 一暁, 五十嵐 真由子, 土田 純子, 永橋 昌幸, 田澤 立之, 栗山 洋子, 藤田 沙織里, 小山 諭, 菊池 朗, 佐藤 信昭, 金子 耕司, 田村 恵美子, 三冨 亜希, 後藤 清恵

    日本婦人科腫瘍学会雑誌   37 ( 3 )   328 - 328   2019年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • Association of statins, aspirin, and venous thromboembolism in women with endometrial cancer. 査読 国際誌

    Koji Matsuo, Marianne S Hom, Akira Yabuno, Masako Shida, Mamoru Kakuda, Sosuke Adachi, Rachel S Mandelbaum, Yutaka Ueda, Kosei Hasegawa, Takayuki Enomoto, Mikio Mikami, Lynda D Roman

    Gynecologic oncology   152 ( 3 )   605 - 611   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: The anti-thrombogenic effects of statins and aspirin have been reported in various malignancies but have not been well examined in endometrial cancer. This study examined the association between statin and/or aspirin use and venous thromboembolism (VTE) risk in endometrial cancer. METHODS: This is a multi-center retrospective study examining 2527 women with endometrial cancer between 2000 and 2015. Statin and aspirin use at diagnosis was correlated to VTE risk during follow-up on multivariable analysis. RESULTS: There were 132 VTE events with a 5-year cumulative incidence rate of 6.1%. There were 392 (15.5%) statin users and 219 (8.7%) aspirin users, respectively. On multivariable analysis, statin use was associated with an approximately 60% decreased risk of VTE when compared to non-users (5-year cumulative rates 2.5% versus 6.7%, adjusted-hazard ratio [HR] 0.42, 95% confidence interval [CI] 0.19-0.92, P = 0.030) whereas aspirin did not demonstrate statistical significance (2.0% versus 6.5%, adjusted-HR 0.54, 95%CI 0.19-1.51, P = 0.24). There was a trend of joint effect between statin and aspirin although it did not demonstrate statistical significance: VTE risks for dual statin/aspirin user (adjusted-HR 0.27, 95%CI 0.04-2.07), statin alone (adjusted-HR 0.40, 95%CI 0.18-0.93), and aspirin alone (adjusted-HR 0.51, 95%CI 0.16-1.64) compared to non-use after adjusting for patient characteristics, tumor factors, treatment types, and survival events (P-interaction = 0.090). When stratified by statin type, simvastatin demonstrated the largest reduction of VTE risk (5-year cumulative rates 1.1% versus 6.7%, adjusted-HR 0.17, 95%CI 0.02-1.30, P = 0.088). Obesity, absence of diabetes mellitus, type II histology, and recurrent disease were the factors associated with decreased VTE risk with statin use (all, P-interaction<0.05). CONCLUSION: Our study suggests that statin use may be associated with decreased risk of VTE in women with endometrial cancer.

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  • Ectopic pregnancy following oral levonorgestrel emergency contraception use. 査読 国際誌

    Kitani Y, Ishiguro T, Kobayashi A, Tamura R, Ueda H, Adachi S, Nishikawa N, Sekine M, Enomoto T

    J Obstet Gynaecol Res.   45 ( 2 )   473 - 476   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jog.13815

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  • Bivalent Human Papillomavirus Vaccine Effectiveness in a Japanese Population: High Vaccine-Type-Specific Effectiveness and Evidence of Cross-Protection. 査読 国際誌

    Kudo R, Yamaguchi M, Sekine M, Adachi S, Ueda Y, Miyagi E, Hara M, Hanley SJB, Enomoto T

    J Infect Dis.   219 ( 3 )   382 - 390   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/infdis/jiy516

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  • Proposal for a Risk-Based Categorization of Uterine Carcinosarcoma. 査読 国際誌

    Koji Matsuo, Yutaka Takazawa, Malcolm S Ross, Esther Elishaev, Mayu Yunokawa, Todd B Sheridan, Stephen H Bush, Merieme M Klobocista, Erin A Blake, Tadao Takano, Tsukasa Baba, Shinya Satoh, Masako Shida, Yuji Ikeda, Sosuke Adachi, Takuhei Yokoyama, Munetaka Takekuma, Shiori Yanai, Satoshi Takeuchi, Masato Nishimura, Keita Iwasaki, Marian S Johnson, Masayuki Yoshida, Ardeshir Hakam, Hiroko Machida, Paulette Mhawech-Fauceglia, Yutaka Ueda, Kiyoshi Yoshino, Hiroshi Kajiwara, Kosei Hasegawa, Masanori Yasuda, Takahito M Miyake, Takuya Moriya, Yoshiaki Yuba, Terry Morgan, Tomoyuki Fukagawa, Tanja Pejovic, Tadayoshi Nagano, Takeshi Sasaki, Abby M Richmond, Miriam D Post, Mian M K Shahzad, Dwight D Im, Hiroshi Yoshida, Takayuki Enomoto, Kohei Omatsu, Frederick R Ueland, Joseph L Kelley, Rouzan G Karabakhtsian, Lynda D Roman

    Annals of surgical oncology   25 ( 12 )   3676 - 3684   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PURPOSE: To propose a categorization model of uterine carcinosarcoma (UCS) based on tumor cell types (carcinoma and sarcoma) and sarcoma dominance. METHODS: This secondary analysis of a prior multicenter retrospective study examined 889 cases of UCS with available histologic evaluation. Based on survival outcome, cases were clustered into three groups: low-grade carcinoma with nondominant homologous sarcoma [type A, n = 96 (10.8%)], (1) low-grade carcinoma with heterologous sarcoma or any sarcoma dominance and (2) high-grade carcinoma with nondominant homologous sarcoma [type B, n = 412 (46.3%)], and high-grade carcinoma with heterologous sarcoma or any sarcoma dominance [type C, n = 381 (42.9%)]. Tumor characteristics and outcome were examined based on the categorization. RESULTS: Women in type C category were more likely to be older, obese, and Caucasian, whereas those in type A category were younger, less obese, Asian, and nulligravid (all P < 0.01). Type C tumors were more likely to have metastatic implants, large tumor size, lymphovascular space invasion with sarcoma cells, and higher lymph node ratio, whereas type A tumors were more likely to be early-stage disease and small (all P < 0.05). On multivariate analysis, tumor categorization was independently associated with progression-free survival (5-year rates: 70.1% for type A, 48.3% for type B, and 35.9% for type C, adjusted P < 0.01) and cause-specific survival (5-year rates: 82.8% for type A, 63.0% for type B, and 47.1% for type C, adjusted P < 0.01). CONCLUSION: Characteristic differences in clinicopathological factors and outcomes in UCS imply that different underlying etiologies and biological behaviors may be present, supporting a new classification system.

    DOI: 10.1245/s10434-018-6695-z

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  • Clinical utility of CA-125 in the management of uterine carcinosarcoma.

    Matsuo K, Ross MS, Yunokawa M, Johnson MS, Machida H, Omatsu K, Klobocista MM, Im DD, Satoh S, Baba T, Ikeda Y, Bush SH, Hasegawa K, Blake EA, Takekuma M, Shida M, Nishimura M, Adachi S, Pejovic T, Takeuchi S, Yokoyama T, Ueda Y, Iwasaki K, Miyake TM, Yanai S, Nagano T, Takano T, Shahzad MM, Ueland FR, Kelley JL, Roman LD

    J Gynecol Oncol.   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • HPVワクチン接種による子宮頸がん検診細胞診異常例におけるハイリスクHPV感染率の変化

    工藤 梨沙, 関根 正幸, 山口 真奈子, 安達 聡介, 八木 麻美, 上田 豊, 原 めぐみ, Hanley Sharon, 宮城 悦子, 榎本 隆之

    日本癌治療学会学術集会抄録集   56回   PS - 6   2018年10月

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    記述言語:英語   出版者・発行元:(一社)日本癌治療学会  

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  • Significance of Lymphovascular Space Invasion by the Sarcomatous Component in Uterine Carcinosarcoma. 査読 国際誌

    Koji Matsuo, Yutaka Takazawa, Malcolm S Ross, Esther Elishaev, Mayu Yunokawa, Todd B Sheridan, Stephen H Bush, Merieme M Klobocista, Erin A Blake, Tadao Takano, Tsukasa Baba, Shinya Satoh, Masako Shida, Yuji Ikeda, Sosuke Adachi, Takuhei Yokoyama, Munetaka Takekuma, Shiori Yanai, Satoshi Takeuchi, Masato Nishimura, Keita Iwasaki, Marian S Johnson, Masayuki Yoshida, Ardeshir Hakam, Hiroko Machida, Paulette Mhawech-Fauceglia, Yutaka Ueda, Kiyoshi Yoshino, Hiroshi Kajiwara, Kosei Hasegawa, Masanori Yasuda, Takahito M Miyake, Takuya Moriya, Yoshiaki Yuba, Terry Morgan, Tomoyuki Fukagawa, Tanja Pejovic, Tadayoshi Nagano, Takeshi Sasaki, Abby M Richmond, Miriam D Post, Mian M K Shahzad, Dwight D Im, Hiroshi Yoshida, Takayuki Enomoto, Kohei Omatsu, Frederick R Ueland, Joseph L Kelley, Rouzan G Karabakhtsian, Lynda D Roman

    Annals of surgical oncology   25 ( 9 )   2756 - 2766   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: The aim of this study was to examine the significance of lymphovascular space invasion (LVSI) with a sarcomatous component on the tumor characteristics and clinical outcomes of women with uterine carcinosarcoma (UCS). METHODS: This was a secondary analysis of a prior multicenter retrospective study that examined women with stage I-IV UCS who underwent primary hysterectomy. Archived histopathology slides were reviewed and LVSI was scored as follows: LVSI with a carcinomatous component alone (LVSI-carcinoma; n = 375, 76.8%) or LVSI containing a sarcomatous component with or without a carcinomatous component (LVSI-sarcoma; n = 113, 23.2%). Qualitative metrics of LVSI were correlated to clinicopathological factors and survival outcome. RESULTS: Tumors in the LVSI-sarcoma group were more likely to have sarcoma dominance (82.1 vs. 26.4%) heterologous sarcomatous component (51.3 vs. 37.9%), low-grade carcinoma (42.5 vs. 22.4%), and large tumor size (81.0 vs. 70.2%) in the primary tumor site compared with tumors in the LVSI-carcinoma group (all p < 0.05). On multivariate analysis, LVSI-sarcoma was independently associated with decreased progression-free survival (5-year rates: 34.9 vs. 40.8%, adjusted hazard ratio [HR] 1.84, 95% confidence interval [CI] 1.36-2.50, p < 0.001), and cause-specific survival (5-year rates: 41.8 vs. 55.9%, adjusted HR 1.95, 95% CI 1.39-2.75, p < 0.001) compared with LVSI-carcinoma. Postoperative radiotherapy for women with LVSI-sarcoma had a higher reduction rate of recurrence/progression of disease (54% reduction, p = 0.04) compared with postoperative radiotherapy for women with LVSI-carcinoma (26% reduction, p = 0.08). CONCLUSION: In UCS, the presence of a sarcomatous component in LVSI is particularly prevalent when a tumor has sarcoma dominance. Our study suggests that LVSI containing a sarcomatous component may be a predictor of decreased survival for women with UCS.

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  • Characterizing sarcoma dominance pattern in uterine carcinosarcoma: Homologous versus heterologous element. 査読 国際誌

    Koji Matsuo, Yutaka Takazawa, Malcolm S Ross, Esther Elishaev, Mayu Yunokawa, Todd B Sheridan, Stephen H Bush, Merieme M Klobocista, Erin A Blake, Tadao Takano, Tsukasa Baba, Shinya Satoh, Masako Shida, Yuji Ikeda, Sosuke Adachi, Takuhei Yokoyama, Munetaka Takekuma, Shiori Yanai, Satoshi Takeuchi, Masato Nishimura, Keita Iwasaki, Marian S Johnson, Masayuki Yoshida, Ardeshir Hakam, Hiroko Machida, Paulette Mhawech-Fauceglia, Yutaka Ueda, Kiyoshi Yoshino, Hiroshi Kajiwara, Kosei Hasegawa, Masanori Yasuda, Takahito M Miyake, Takuya Moriya, Yoshiaki Yuba, Terry Morgan, Tomoyuki Fukagawa, Tanja Pejovic, Tadayoshi Nagano, Takeshi Sasaki, Abby M Richmond, Miriam D Post, Mian M K Shahzad, Dwight D Im, Hiroshi Yoshida, Kohei Omatsu, Frederick R Ueland, Joseph L Kelley, Rouzan G Karabakhtsian, Lynda D Roman

    Surgical oncology   27 ( 3 )   433 - 440   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: To examine significance of sarcoma dominance (SD) patterns in uterine carcinosarcoma (UCS). METHODS: This is a secondary analysis of multicenter retrospective study examining women with stages I-IV UCS who underwent primary surgery. SD was defined as >50% of sarcoma component in uterine tumor. SD patterns were grouped as homologous sarcoma without SD (homo/non-dominance, n = 351), heterologous sarcoma without SD (hetero/non-dominance, n = 174), homologous sarcoma with SD (homo/dominance, n = 175), and heterologous sarcoma with SD (hetero/dominance, n = 189), and correlated to tumor characteristics and survival. RESULTS: SD patterns were significantly associated with age, body habitus, carcinoma type, tumor size, depth of myometrial invasion, and nodal metastasis (all, P < 0.05). On univariate analysis, SD was associated with decreased progression-free survival (PFS) and cause-specific survival (CSS) in homologous cases (both, P < 0.05) but not in heterologous cases. On multivariate models, both homologous and heterologous SD patterns remained independent prognostic factors for decreased PFS (adjusted-hazard ratio [HR] ranges: homo/dominance 1.35-1.69, and hetero/dominance 1.47-1.64) and CSS (adjusted-HR ranges: 1.52-1.84 and 1.66-1.81, respectively) compared to homo/non-dominance (all, P < 0.05). Among stage I-III disease, when tumors had SD, adding radiotherapy to chemotherapy was significantly associated with improved PFS (adjusted-HR: homo/dominance 0.49, and hetero/dominance 0.45) and CSS (0.36 and 0.31, respectively) compared to chemotherapy alone (all, P < 0.05); contrary, this association was not observed with absence of SD (all, P > 0.05). CONCLUSION: In UCS, SD impacts survival in homologous but not in heterologous type. Regardless of sarcoma types, SD was associated with decreased survival in UCS; adding radiotherapy to chemotherapy may be an effective postoperative strategy.

    DOI: 10.1016/j.suronc.2018.05.017

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  • Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium. 査読 国際誌

    Suda K, Nakaoka H, Yoshihara K, Ishiguro T, Tamura R, Mori Y, Yamawaki K, Adachi S, Takahashi T, Kase H, Tanaka K, Yamamoto T, Motoyama T, Inoue I, Enomoto T

    Cell Rep.   24 ( 7 )   1777 - 1789   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.celrep.2018.07.037

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  • 女性の家族性がん 新潟県におけるHBOC診療体制の確立に向けての取り組み

    西野 幸治, 須田 一暁, 安達 聡介, 吉原 弘祐, 関根 正幸, 榎本 隆之, 五十嵐 真由子, 土田 純子, 中島 真人, 永橋 昌幸, 田澤 立之, 栗山 洋子, 藤田 沙織里, 小山 諭, 菊池 朗, 佐藤 信昭, 金子 耕司, 田村 恵美子, 三富 亜希, 後藤 清恵

    人間ドック   33 ( 2 )   232 - 232   2018年8月

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    記述言語:日本語   出版者・発行元:(公社)日本人間ドック学会  

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  • Significance of abnormal peritoneal cytology on survival of women with stage I–II endometrioid endometrial cancer 査読

    Koji Matsuo, Akira Yabuno, Marianne S. Hom, Masako Shida, Mamoru Kakuda, Sosuke Adachi, Rachel S. Mandelbaum, Yutaka Ueda, Kosei Hasegawa, Takayuki Enomoto, Mikio Mikami, Lynda D. Roman

    Gynecologic Oncology   149 ( 2 )   301 - 309   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Academic Press Inc.  

    Objective: To examine survival of women with stage I–II endometrioid endometrial cancer whose peritoneal cytology showed malignant or atypical cells (abnormal peritoneal cytology). Methods: This is a multi-center retrospective study examining 1668 women with stage I–II endometrioid endometrial cancer who underwent primary hysterectomy with available peritoneal cytology results between 2000 and 2015. Abnormal peritoneal cytology was correlated to clinico-pathological characteristics and oncological outcome. Results: Malignant and atypical cells were seen in 125 (7.5%) and 58 (3.5%) cases, respectively. On multivariate analysis, non-obesity, non-diabetes mellitus, cigarette use, and lympho-vascular space invasion were independently associated with abnormal peritoneal cytology (all, P &lt
    0.05). Abnormal peritoneal cytology was independently associated with decreased disease-free survival (hazard ratio 3.07, P &lt
    0.001) and cause-specific survival (hazard ratio 3.42, P = 0.008) on multivariate analysis. Abnormal peritoneal cytology was significantly associated with increased risks of distant-recurrence (5-year rates: 8.8% versus 3.6%, P = 0.001) but not local-recurrence (5.2% versus 3.0%, P = 0.32) compared to negative cytology. Among women with stage I disease, abnormal peritoneal cytology was significantly associated with an increased risk of distant-recurrence in the low risk group (5-year rates: 5.5% versus 1.0%, P &lt
    0.001) but not in the high-intermediate risk group (13.3% versus 10.8% P = 0.60). Among 183 women who had abnormal peritoneal cytology, postoperative chemotherapy significantly reduced the rate of peritoneal recurrence (5-year rates: 1.3% versus 9.2%, P = 0.039) whereas postoperative radiotherapy did not (7.1% versus 5.5%, P = 0.63). Conclusion: Our study suggests that abnormal peritoneal cytology may be a prognostic factor for decreased survival in women with stage I–II endometrioid endometrial cancer, particularly for low-risk group.

    DOI: 10.1016/j.ygyno.2018.02.012

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  • The Safety and Effectiveness of Abdominal Radical Trachelectomy for Early-Stage Cervical Cancer During Pregnancy. 査読

    Yoshihara K, Ishiguro T, Chihara M, Shima E, Adachi S, Isobe M, Haino K, Yamaguchi M, Sekine M, Kashima K, Takakuwa K, Nishikawa N, Enomoto T

    Int J Gynecol Cancer.   28 ( 4 )   782 - 787   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/IGC.0000000000001218

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  • Differential misclassification between self-reported status and official HPV vaccination records in Japan: Implications for evaluating vaccine safety and effectiveness. 査読

    Yamaguchi M, Sekine M, Kudo R, Adachi S, Ueda Y, Miyagi E, Hara M, Hanley SJB, Enomoto T

    Papillomavirus Res.   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Survival outcome of women with stage IV uterine carcinosarcoma who received neoadjuvant chemotherapy followed by surgery 査読

    Koji Matsuo, Marian S. Johnson, Dwight D. Im, Malcolm S. Ross, Stephen H. Bush, Mayu Yunokawa, Erin A. Blake, Tadao Takano, Merieme M. Klobocista, Kosei Hasegawa, Yutaka Ueda, Masako Shida, Tsukasa Baba, Shinya Satoh, Takuhei Yokoyama, Hiroko Machida, Yuji Ikeda, Sosuke Adachi, Takahito M. Miyake, Keita Iwasaki, Shiori Yanai, Satoshi Takeuchi, Masato Nishimura, Tadayoshi Nagano, Munetaka Takekuma, Mian M. K. Shahzad, Tanja Pejovic, Kohei Omatsu, Joseph L. Kelley, Frederick R. Ueland, Lynda D. Roman

    Journal of Surgical Oncology   117 ( 3 )   488 - 496   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:John Wiley and Sons Inc.  

    Background and Objectives: To examine survival of women with stage IV uterine carcinosarcoma (UCS) who received neoadjuvant chemotherapy followed by hysterectomy. Methods: This is a nested case-control study within a retrospective cohort of 1192 UCS cases. Women who received neoadjuvant chemotherapy followed by hysterectomy based-surgery for stage IV UCS (n = 26) were compared to those who had primary hysterectomy-based surgery without neoadjuvant chemotherapy for stage IV UCS (n = 120). Progression-free survival (PFS) and cause-specific survival (CSS) were examined. Results: The most common regimen for neoadjuvant chemotherapy was carboplatin/paclitaxel (53.8%). Median number of neoadjuvant chemotherapy cycles was 4. PFS was similar between the neoadjuvant chemotherapy group and the primary surgery group (unadjusted-hazard ratio [HR] 1.19, 95% confidence interval [CI] 0.75-1.89, P = 0.45). Similarly, CSS was comparable between the two groups (unadjusted-HR 1.13, 95%CI 0.68-1.90, P = 0.64). When the types of neoadjuvant chemotherapy regimens were compared, women who received a carboplatin/paclitaxel regimen had better survival outcomes compared to those who received other regimens: PFS, unadjusted-HR 0.38, 95%CI 0.15-0.93, P = 0.027
    and CSS, unadjusted-HR 0.21, 95%CI 0.07-0.61, P = 0.002. Conclusion: Our study found that there is no statistically significant difference in survival between women with stage IV UCS who are tolerated neoadjuvant chemotherapy and those who undergo primary surgery.

    DOI: 10.1002/jso.24861

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  • Significance of venous thromboembolism in women with uterine carcinosarcoma. 査読

    Matsuo K, Ross MS, Im DD, Klobocista MM, Bush SH, Johnson MS, Takano T, Blake EA, Ikeda Y, Nishimura M, Ueda Y, Shida M, Hasegawa K, Baba T, Adachi S, Yokoyama T, Satoh S, Machida H, Yanai S, Iwasaki K, Miyake TM, Takeuchi S, Takekuma M, Nagano T, Yunokawa M, Pejovic T, Omatsu K, Shahzad MMK, Kelley JL, Ueland FR, Roman LD

    Gynecol Oncol.   148 ( 2 )   267 - 274   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ygyno.2017.11.036

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  • Salvage chemotherapy with taxane and platinum for women with recurrent uterine carcinosarcoma 査読

    Koji Matsuo, Malcolm S. Ross, Mayu Yunokawa, Marian S. Johnson, Hiroko Machida, Kohei Omatsu, Merieme M. Klobocista, Dwight D. Im, Shinya Satoh, Tsukasa Baba, Yuji Ikeda, Stephen H. Bush, Kosei Hasegawa, Erin A. Blake, Munetaka Takekuma, Masako Shida, Masako Nishimura, Sosuke Adachi, Tanja Pejovic, Satoshi Takeuchi, Takuhei Yokoyama, Yutaka Ueda, Keita Iwasaki, Takahito M. Miyake, Shiori Yanai, Tadayoshi Nagano, Tadao Takano, Mian M. K. Shahzad, Frederick R. Ueland, Joseph L. Kelley, Lynda D. Roman

    GYNECOLOGIC ONCOLOGY   147 ( 3 )   565 - 571   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Objective. To examine survival after recurrence (SAR) among women with recurrent uterine carcinosarcoma who received a taxane/platinum doublet as the first-line salvage chemotherapy.
    Methods. We retrospectively examined 148 women with recurrent uterine carcinosarcoma who received salvage chemotherapy within a cohort of 906 uterine carcinosarcomas. An independent association of salvage chemotherapy type and SAR was examined with multivariate analysis.
    Results. There were 71 (48.0%) women who received a taxane/platinum regimen. On univariate analysis, women who received a taxane/platinum doublet had a higher 2-year SAR rate compared to women who received non-taxane/platinum regimens (55.5% versus 34.8%, P &lt; 0.001). On multivariate analysis, use of taxane/platinum regimen was independently associated with improved SAR compared to the non-taxane/platinum regimens (adjusted-hazard ratio [HR] 0.56, 95% confidence interval [CI] 035 to 0.91, P = 0.02). When stratified by disease-free interval, women with a disease-free interval &gt;= 6 months who received a taxane/platinum doublet had a higher 2-year SAR rate compared to those who received non-taxane/platinum regimens (61.9% versus 40.0%, HR 0.46, 95% CI 028 to 0.75, P = 0.002); conversely, in women with a disease-free interval &lt;6 months, 2-year SAR rates were similar between the two groups (20.5% versus 18.4%, HR 0.80, 95% CI 033 to 1.90, P = 0.61). Among women who received a taxane/platinum doublet as adjuvant chemotherapy, re-treatment with taxane/platinum doublet as salvage chemotherapy remained beneficial (2-year SAR rate, 62.1% versus 39.7%, HR 0.40, 95% CI 0.18 to 0.86, P = 0.019).
    Conclusion. Our study suggests that taxane/platinum doublet may be a more effective chemotherapy regimen compared to other regimens among women with recurrent uterine carcinosarcoma, especially for those who had a disease-free interval of &gt;= 6 months. (C) 2017 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.ygyno.2017.10.008

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  • 日本人若年女性のsexual activityとHPV感染、子宮頸部細胞診異常との相関 査読

    山口 真奈子, 工藤 梨沙, 安達 聡介, 関根 正幸, 八木 麻未, 田中 佑典, 上田 豊, 宮城 悦子, 榎本 隆之

    日本癌治療学会学術集会抄録集   55回   P165 - 1   2017年10月

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    記述言語:日本語   出版者・発行元:(一社)日本癌治療学会  

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  • 日本人若年女性におけるHPVワクチン公費接種者のHPV感染予防効果 査読

    工藤 梨沙, 山口 真奈子, 安達 聡介, 関根 正幸, 八木 麻未, 田中 佑典, 上田 豊, 宮城 悦子, 榎本 隆之

    日本癌治療学会学術集会抄録集   55回   PS - 6   2017年10月

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    記述言語:日本語   出版者・発行元:(一社)日本癌治療学会  

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  • Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism. 査読

    Sapkota Y, Steinthorsdottir V, Morris AP, Fassbender A, Rahmioglu N, De Vivo I, Buring JE, Zhang F, Edwards TL, Jones S, O D, Peterse D, Rexrode KM, Ridker PM, Schork AJ, MacGregor S, Martin NG, Becker CM, Adachi S, Yoshihara K, Enomoto T, Takahashi A, Kamatani Y, Matsuda K, Kubo M, Thorleifsson G, Geirsson RT, Thorsteinsdottir U, Wallace LM, iPSYCH-SSI-Broad Group, Yang J, Velez Edwards DR, Nyegaard M, Low SK, Zondervan KT, Missmer SA, D'Hooghe T, Montgomery GW, Chasman DI, Stefansson K, Tung JY, Nyholt DR

    Nat Commun.   8   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/ncomms15539

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  • Impact of adjuvant therapy on recurrence patterns in stage I uterine carcinosarcoma 査読

    Koji Matsuo, Kohei Omatsu, Malcolm S. Ross, Marian S. Johnson, Mayu Yunokawa, Merieme M. Klobocista, Dwight D. Im, Stephen H. Bush, Yutaka Ueda, Tadao Takano, Erin A. Blake, Kosei Hasegawa, Tsukasa Baba, Masako Shida, Shinya Satoh, Takuhei Yokoyama, Hiroko Machida, Sosuke Adachi, Yuji Ikeda, Keita Iwasaki, Takahito M. Miyake, Shiori Yanai, Masato Nishimura, Tadayoshi Nagano, Munetaka Takekuma, Satoshi Takeuchi, Tanja Pejovic, Mian Mk Shahzad, Frederick R. Ueland, Joseph L. Kelley, Lynda D. Roman

    GYNECOLOGIC ONCOLOGY   145 ( 1 )   78 - 87   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Background. To examine recurrence patterns in women with stage I uterine carcinosarcoma (UCS) stratified by adjuvant therapy pattern.
    Methods. We examined 443 cases of stage I UCS derived from a retrospective cohort of 1192 UCS cases from 26 institutions. Adjuvant therapy patterns after primary hysterectomy-based surgery were correlated to recurrence patterns.
    Results. The most common adjuvant therapy was chemotherapy alone (41.5%) followed by chemotherapy/radiotherapy (15.8%) and radiotherapy alone (8.4%). Distant-recurrence was the most common recurrence pattern (5-year cumulative rate, 28.1%) followed by local-recurrence (13.3%). On multivariate analysis, chemotherapy but not radiotherapy remained an independent prognostic factor for decreased risk of local-recurrence (5-year cumulative rates 8.7% versus 19.8%, adjusted-hazard ratio [HR] 0.46, 95% confidence interval [CI] 0.25-0.83, P = 0.01) and distant-recurrence (21.2% versus 38.0%, adjusted-HR 0.41, 95%Cl 027-0.62, P &lt; 0.001). The chemotherapy/radiotherapy group had a lower 5-year cumulative local-recurrence rate compared to the chemotherapy alone group but it did not reach statistical significance (5.1% versus 10.1%, adjusted-HR 0.46, 95%Cl 0.13-1.58, P = 022). Radiotherapy significantly decreased local-recurrence when tumors had high-grade carcinoma, sarcoma component dominance, and deep myometrial tumor invasion (all, P &lt; 0.05); and combining radiotherapy with chemotherapy was significantly associated with decreased local-recurrence compared to chemotherapy alone in the presence of multiple risk factors (5-year cumulative rates, 2.5% versus 21.8%, HR 0.12, 95%CI 0.02-0.90; P = 0.013) but not in none/single factor (P = 0.36).
    Conclusion. Adjuvant chemotherapy appears to be effective to control both local- and distant-recurrences in stage I UCS; adding radiotherapy to chemotherapy may be effective to control local-recurrence when the tumor exhibits multiple risk factors. (C) 2017 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.ygyno.2017.02.001

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  • Tumor characteristics and survival outcomes of women with tamoxifen-related uterine carcinosarcoma 査読

    Koji Matsuo, Malcolm S. Ross, Stephen H. Bush, Mayu Yunokawa, Erin A. Blake, Tadao Takano, Yutaka Ueda, Tsukasa Baba, Shinya Satoh, Masako Shida, Yuji Ikeda, Sosuke Adachi, Takuhei Yokoyama, Munetaka Takekuma, Satoshi Takeuchi, Masato Nishimura, Keita Iwasaki, Shiori Yanai, Merieme M. Klobocista, Marian S. Johnson, Hiroko Machida, Kosei Hasegawa, Takahito M. Miyake, Tadayoshi Nagano, Tanja Pejovic, Mian M. K. Shahzad, Dwight D. Im, Kohei Omatsu, Frederick R. Ueland, Joseph L. Kelley, Lynda D. Roman

    GYNECOLOGIC ONCOLOGY   144 ( 2 )   329 - 335   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Objective. To examine tumor characteristics and survival outcome of women with uterine carcinosarcoma who had a history of tamoxifen use.
    Methods. This is a multicenter retrospective study examining stage I-IV uterine carcinosarcoma cases based on history of tamoxifen use. Patient demographics, tumor characteristics, treatment pattern, and survival outcomes were compared between tamoxifen users and non-users.
    Results. Sixty-six cases of tamoxifen-related uterine carcinosarcoma were compared to 1009 cases with no history of tamoxifen use. Tamoxifen users were more likely to be older (mean age, 69 versus 64, P &lt; 0.001) and had a past history of malignancy (100% versus 12.7%, P &lt; 0.001). Tamoxifen-related uterine carcinosarcoma was significantly associated with a higher proportion of stage IA disease (48.4% versus 29.9%) and a lower risk of stage IVB disease (7.8% versus 16.0%) compared to tamoxifen-unrelated carcinosarcoma (P = 0.034). Deep myometrial tumor invasion was less common in uterine carcinosarcoma related to tamoxifen use (28.3% versus 48.8%, P = 0.002). On univariate analysis, tamoxifen use was not associated with progression-free survival (5-year rates 44.5% versus 46.8%, P = 0.48) and disease-specific survival (64.0% versus 59.1%, P = 0.39). After adjusting for age, past history of malignancy, stage, residual disease status at surgery, and postoperative treatment patterns, tamoxifen use was not associated with progression-free survival (adjusted-hazard ratio 0.86, 95% confidence interval 0.50 to 1.50, P = 0.60) and disease-specific survival (adjusted-hazard ratio 0.68, 95% confidence interval 0.36 to 1.29, P = 0.24).
    Conclusion. Our study suggests that tamoxifen-related uterine carcinosarcoma may have favorable tumor characteristics but have comparable stage-specific survival outcomes compared to tamoxifen-unrelated uterine carcinosarcoma. (C) 2016 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.ygyno.2016.11.042

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  • ヒトパピローマウイルス(HPV)検査におけるハイリスクスクリーニング法とジェノタイピング法による結果不一致例の検討 査読

    工藤 梨沙, 関根 正幸, 山口 真奈子, 安達 聡介, 榎本 隆之, 上田 豊, 高田 友美, 森本 晶子, 田中 佑典, 八木 麻未

    日本産科婦人科学会雑誌   69 ( 2 )   674 - 674   2017年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • Realistic fear of cervical cancer risk in Japan depending on birth year. 査読

    Yagi A, Ueda Y, Egawa-Takata T, Tanaka Y, Nakae R, Morimoto A, Terai Y, Ohmichi M, Ichimura T, Sumi T, Murata H, Okada H, Nakai H, Mandai M, Matsuzaki S, Kobayashi E, Yoshino K, Kimura T, Saito J, Hori Y, Morii E, Nakayama T, Suzuki Y, Motoki Y, Sukegawa A, Asai-Sato M, Miyagi E, Yamaguchi M, Kudo R, Adachi S, Sekine M, Enomoto T, Horikoshi Y, Takagi T, Shimura K

    Hum Vaccin Immunother.   13 ( 7 )   1700 - 1704   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/21645515.2017.1292190

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  • Project conducted in Hirakata to improve cervical cancer screening rates in 20-year-old Japanese: Influencing parents to recommend that their daughters undergo cervical cancer screening 査読

    Asami Yagi, Yutaka Ueda, Tomomi Egawa-Takata, Yusuke Tanaka, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Masaki Mandai, Shinya Matsuzaki, Eiji Kobayashi, Kiyoshi Yoshino, Tadashi Kimura, Junko Saito, Yumiko Hori, Eiichi Morii, Tomio Nakayama, Yukio Suzuki, Yoko Motoki, Akiko Sukegawa, Mikiko Asai-Sato, Etsuko Miyagi, Manako Yamaguchi, Risa Kudo, Sosuke Adachi, Masayuki Sekine, Takayuki Enomoto, Yorihiko Horikoshi, Tetsu Takagi, Kentaro Shimura

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   42 ( 12 )   1802 - 1807   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Aim: In Japan, the rate of routine cervical cancer screening is quite low, and the incidence of cervical cancer has recently been increasing. Our objective was to investigate ways to effectively influence parental willingness to recommend that their 20-year-old daughters undergo cervical cancer screening.
    Methods: We targeted parents whose 20-year-old daughters were living with them. In fiscal year 2013, as usual, the daughter received a reminder postcard several months after they had received a free coupon for cervical cancer screening. In fiscal year 2014, the targeted parents received a cervical cancer information leaflet, as well as a cartoon about cervical cancer to show to their daughters, with a request that they recommend to their daughter that she undergo cervical cancer screening. The subsequent screening rates for fiscal years 2013 and 2014 were compared.
    Results: The cervical cancer screening rate of 20-year-old women whose parents received the information packet in fiscal year 2014 was significantly higher than for the women who, in fiscal year 2013, received only a simple reminder postcard (P &lt; 0.001). As a result, the total screening rate for 20-year-old women for the whole of the 2014 fiscal year was significantly increased over 2013 (P &lt; 0.001).
    Conclusion: For the first time, we have shown that the parents of 20-year-old daughters can be motivated to recommend that their daughters receive their first cervical cancer screening. This was achieved by sending a cervical cancer information leaflet and a cartoon about cervical cancer for these parents to show to their daughters. This method was significantly effective for improving cervical cancer screening rates.

    DOI: 10.1111/jog.13122

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  • Association of Low-Dose Aspirin and Survival of Women With Endometrial Cancer 査読

    Koji Matsuo, Sigita S. Cahoon, Kosuke Yoshihara, Masako Shida, Mamoru Kakuda, Sosuke Adachi, Aida Moeini, Hiroko Machida, Jocelyn Garcia-Sayre, Yutaka Ueda, Takayuki Enomoto, Mikio Mikami, Lynda D. Roman, Anil K. Sood

    OBSTETRICS AND GYNECOLOGY   128 ( 1 )   127 - 137   2016年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    OBJECTIVE: To examine the survival outcomes in women with endometrial cancer who were taking low-dose aspirin (81-100 mg/d).
    METHODS: A multicenter retrospective study was conducted examining patients with stage I-IV endometrial cancer who underwent hysterectomy-based surgical staging between January 2000 and December 2013 (N=1,687). Patient demographics, medical comorbidities, medication types, tumor characteristics, and treatment patterns were correlated to survival outcomes. A Cox proportional hazard regression model was used to estimate adjusted hazard ratio for disease-free and disease-specific overall survival.
    RESULTS: One hundred fifty-eight patients (9.4%, 95% confidence interval [CI] 8.8-11.9) were taking low-dose aspirin. Median follow-up time for the study cohort was 31.5 months. One hundred twenty-seven patients (7.5%) died of endometrial cancer. Low-dose aspirin use was significantly correlated with concurrent obesity, hypertension, diabetes mellitus, and hypercholesterolemia (all P&lt;.001). Low-dose aspirin users were more likely to take other antihypertensive, antiglycemic, and anticholesterol agents (all P&lt;.05). Low-dose aspirin use was not associated with histologic subtype, tumor grade, nodal metastasis, or cancer stage (all P&gt;.05). On multivariable analysis, low-dose aspirin use remained an independent prognostic factor associated with an improved 5-year disease-free survival rate (90.6% compared with 80.9%, adjusted hazard ratio 0.46, 95% CI 0.25-0.86, P=.014) and disease-specific overall survival rate (96.4% compared with 87.3%, adjusted hazard ratio 0.23, 95% CI 0.08-0.64, P=.005). The increased survival effect noted with low-dose aspirin use was greatest in patients whose age was younger than 60 years (5-year disease-free survival rates, 93.9% compared with 84.0%, P=.013), body mass index was 30 or greater (92.2% compared with 81.4%, P=.027), who had type I cancer (96.5% compared with 88.6%, P=.029), and who received postoperative whole pelvic radiotherapy (88.2% compared with 61.5%, P=.014). These four factors remained significant for disease-specific overall survival (all P&lt;.05).
    CONCLUSION: Our results suggest that low-dose aspirin use is associated with improved survival outcomes in women with endometrial cancer, especially in those who are young, obese, with low-grade disease, and who receive postoperative radiotherapy.

    DOI: 10.1097/AOG.0000000000001491

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  • Significance of histologic pattern of carcinoma and sarcoma components on survival outcomes of uterine carcinosarcoma. 査読

    Matsuo K, Takazawa Y, Ross MS, Elishaev E, Podzielinski I, Yunokawa M, Sheridan TB, Bush SH, Klobocista MM, Blake EA, Takano T, Matsuzaki S, Baba T, Satoh S, Shida M, Nishikawa T, Ikeda Y, Adachi S, Yokoyama T, Takekuma M, Fujiwara K, Hazama Y, Kadogami D, Moffitt MN, Takeuchi S, Nishimura M, Iwasaki K, Ushioda N, Johnson MS, Yoshida M, Hakam A, Li SW, Richmond AM, Machida H, Mhawech-Fauceglia P, Ueda Y, Yoshino K, Yamaguchi K, Oishi T, Kajiwara H, Hasegawa K, Yasuda M, Kawana K, Suda K, Miyake TM, Moriya T, Yuba Y, Morgan T, Fukagawa T, Wakatsuki A, Sugiyama T, Pejovic T, Nagano T, Shimoya K, Andoh M, Shiki Y, Enomoto T, Sasaki T, Fujiwara K, Mikami M, Shimada M, Konishi I, Kimura T, Post MD, Shahzad MM, Im DD, Yoshida H, Omatsu K, Ueland FR, Kelley JL, Karabakhtsian RG, Roman LD

    Annals of oncology : official journal of the European Society for Medical Oncology   27 ( 7 )   1257 - 1266   2016年7月

  • 20-21歳女性におけるHPVワクチン接種とHPV感染率、および性活動性との相関 査読

    関根 正幸, 山口 真奈子, 工藤 梨沙, 安達 聡介, 田中 佑典, 森本 晶子, 高田 友美, 八木 麻未, 上田 豊, 榎本 隆之

    日本婦人科腫瘍学会雑誌   34 ( 3 )   411 - 411   2016年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • Japanese crisis of HPV vaccination 査読

    Masayuki Sekine, Risa Kudo, Sosuke Adachi, Manako Yamaguchi, Yutaka Ueda, Tomomi Takata, Akiko Morimoto, Yusuke Tanaka, Asami Yagi, Etsuko Miyagi, Takayuki Enomoto

    Int J Pathol Clin Res   2 ( 039s )   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Tumor Characteristics and Survival Outcome of Endometrial Cancer Arising in Adenomyosis: An Exploratory Analysis 査読

    Koji Matsuo, Aida Moeini, Hiroko Machida, Christopher A. Scannell, Jennifer K. Casabar, Mamoru Kakuda, Sosuke Adachi, Jocelyn Garcia-Sayre, Yutaka Ueda, Lynda D. Roman

    ANNALS OF SURGICAL ONCOLOGY   23 ( 3 )   959 - 967   2016年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Background. Endometrial cancer arising in adenomyosis (EC-AIA) is a rare entity of endometrial cancer, and its clinical significance has not been well studied. This study aimed to examine the tumor characteristics and survival outcomes of EC-AIA.
    Methods. An exploratory analysis was performed to compare EC-AIA and historical control cases. For this study, EC-AIA cases were identified via a systematic literature search using PubMed/MEDLINE with entry keywords "endometrial cancer OR uterine cancer'' AND "adenomyosis'' (n = 46). The control group comprised consecutive non-EC-AIA cases from four institutions that had hysterectomy-based surgical staging (n = 1294). Patient demographics, pathology results, and survival outcomes were evaluated between the two groups.
    Results. The EC-AIA group was significantly older than the control group (58.9 vs. 55.3 years; P = 0.032). In terms of tumor characteristics, 56.5 % of the EC-AIA cases showed tumor within the myometrium without endometrial extension, and the EC-AIA group was significantly more likely to have tumors with more than 50 % myometrial invasion (51.6 vs. 26.6 %; P = 0.002) and serous/clear cell histology (22.2 vs. 8.2 %, P = 0.002) while less likely to express estrogen receptor (14.3 vs. 84.6 %; P &lt; 0.001). Grade and stage distributions were similar (P &gt; 0.05). In the univariate analysis, the EC-AIA group had a significantly poorer disease-free survival than the control group (5-year rate: 71.4 vs. 80.6 %; P = 0.014). In the multi-variate analysis, with control for age, ethnicity, histology, grade, and stage, EA-CIC remained an independent prognostic factor for decreased disease-free survival (adjusted hazard ratio, 3.07; 95 % confidence interval 1.55-6.08; P = 0.001).
    Conclusions. The study suggested that endometrial cancer arising in adenomyosis may be an aggressive variant of endometrial cancer.

    DOI: 10.1245/s10434-015-4952-y

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  • インターネット調査による子宮頸癌検診に対する意識調査と有効な勧奨手法 査読

    安達 聡介, 山口 真奈子, 工藤 梨沙, 関根 正幸, 榎本 隆之, 上田 豊, 高田 友美, 森本 晶子, 田中 佑典, 八木 麻未

    日本産科婦人科学会雑誌   68 ( 2 )   825 - 825   2016年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 20-21歳女性におけるHPVワクチン接種とHPV感染率および性活動性との相関 査読

    関根 正幸, 山口 真奈子, 工藤 梨沙, 安達 聡介, 榎本 隆之, 上田 豊, 高田 友美, 森本 晶子, 田中 佑典, 八木 麻未

    日本産科婦人科学会雑誌   68 ( 2 )   825 - 825   2016年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 若年女性を対象としたHPVワクチンに対するインターネット意識調査と有効な勧奨手法 査読

    山口 真奈子, 関根 正幸, 工藤 梨沙, 安達 聡介, 榎本 隆之, 上田 豊, 高田 友美, 森本 晶子, 田中 佑典, 八木 麻未

    日本産科婦人科学会雑誌   68 ( 2 )   823 - 823   2016年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • Association of NR3C1/Glucocorticoid Receptor gene SNP with azoospermia in Japanese men 査読

    Makoto Chihara, Kosuke Yoshihara, Tatsuya Ishiguro, Sosuke Adachi, Hiroyuki Okada, Katsunori Kashima, Takaaki Sato, Atsushi Tanaka, Kenichi Tanaka, Takayuki Enomoto

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   42 ( 1 )   59 - 66   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    AimThe molecular pathogenesis of non-obstructive azoospermia (NOA) is unclear. Our aim was to identify the genetic susceptibility for NOA in Japanese men by using a combination of transcriptome network analysis and SNP genotyping.
    Material and MethodsWe searched for candidate genes using RNA transcriptome network analysis of 2611 NOA-related genes that we had previously reported. We analyzed candidate genes for disease linkage with single nucleotide polymorphisms (SNP) in the genomes of 335 Japanese men with NOA and 410 healthy controls using SNP-specific real-time polymerase chain reaction TaqMan assays.
    ResultsThree candidate genes (NR3C1, YBX2, and BCL2) were identified by the transcriptome network analysis, each with three SNP. Allele frequency analysis of the nine SNP indicated a significantly higher frequency of the NR3C1 rs852977 G allele in NOA cases compared with controls (corrected P = 5.7e-15; odds ratio = 3.20; 95% confidence interval, 2.40-4.26). The other eight candidate polymorphisms showed no significant association.
    ConclusionThe NR3C1 rs852977 polymorphism is a potential marker for genetic susceptibility to NOA in Japanese men. Further studies are necessary to clarify the association between the NR3C1 polymorphism and alterations of glucocorticoid signaling pathway leading to male infertility.

    DOI: 10.1111/jog.12877

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  • Novel kinase fusion transcripts found in endometrial cancer

    Ryo Tamura, Kosuke Yoshihara, Kaoru Yamawaki, Kazuaki Suda, Tatsuya Ishiguro, Sosuke Adachi, Shujiro Okuda, Ituro Inoue, Roel G. W. Verhaak, Takayuki Enomoto

    SCIENTIFIC REPORTS   5   2015年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATURE PUBLISHING GROUP  

    Recent advances in RNA-sequencing technology have enabled the discovery of gene fusion transcripts in the transcriptome of cancer cells. However, it remains difficult to differentiate the therapeutically targetable fusions from passenger events. We have analyzed RNA-sequencing data and DNA copy number data from 25 endometrial cancer cell lines to identify potential therapeutically targetable fusion transcripts, and have identified 124 high-confidence fusion transcripts, of which 69% are associated with gene amplifications. As targetable fusion candidates, we focused on three in-frame kinase fusion transcripts that retain a kinase domain (CPQ-PRKDC, CAPZA2-MET, and VGLL4-PRKG1). We detected only CPQ-PRKDC fusion transcript in three of 122 primary endometrial cancer tissues. Cell proliferation of the fusion-positive cell line was inhibited by knocking down the expression of wild-type PRKDC but not by blocking the CPQ-PRKDC fusion transcript expression. Quantitative real-time RT-PCR demonstrated that the expression of the CPQ-PRKDC fusion transcript was significantly lower than that of wild-type PRKDC, corresponding to a low transcript allele fraction of this fusion, based on RNA-sequencing read counts. In endometrial cancers, the CPQ-PRKDC fusion transcript may be a passenger aberration related to gene amplification. Our findings suggest that transcript allele fraction is a useful predictor to find bona-fide therapeutic-targetable fusion transcripts.

    DOI: 10.1038/srep18657

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  • Susceptibility to male infertility: replication study in Japanese men looking for an association with four GWAS-derived loci identified in European men 査読

    Makoto Chihara, Kosuke Yoshihara, Tatsuya Ishiguro, Yuki Yokota, Sosuke Adachi, Hiroyuki Okada, Katsunori Kashima, Takaaki Sato, Atsushi Tanaka, Kenichi Tanaka, Takayuki Enomoto

    JOURNAL OF ASSISTED REPRODUCTION AND GENETICS   32 ( 6 )   903 - 908   2015年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER/PLENUM PUBLISHERS  

    A previous genome-wide association study in European men identified four single nucleotide polymorphism (SNP) loci associated with male infertility. Our aim was to replicate, if possible, the association of these SNPs with Japanese male infertility.
    We genotyped four SNPs (rs5911500, rs10246939, rs2059807, and rs11204546) in 517 Japanese patients with male infertility and 369 fertile controls using SNP-specific real-time polymerase chain reaction TaqMan assays. Subsequently, we divided patients with male infertility into azoospermia (n = 417) and oligospermia subgroups (n = 70).
    The four SNPs previously identified in European men showed no significant association with collective male infertility in our Japanese cohort. However, allele frequency analysis did indicate a significantly higher frequency of the rs11204546 C allele of the OR2W3 gene in the oligospermia subset of infertility patients compared with controls (p = 0.0037; odds ratio = 1.74; 95 % confidence interval, 1.21-2.53).
    Although this study was somewhat limited by overall sample size, the OR2W3 gene polymorphism rs11204546 was significantly associated with oligospermia in Japanese men, suggesting that OR2W3 might be involved in genetic susceptibility to Japanese male infertility as well as in European males.

    DOI: 10.1007/s10815-015-0468-4

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  • 骨盤リンパ節郭清後、外腸骨血管に腸管が絞扼されたイレウスの2例

    西野 幸治, 安達 聡介, 西川 伸道, 関根 正幸, 榎本 隆之, 山田 沙季, 佐藤 優, 石川 卓, 若井 俊文

    日本婦人科腫瘍学会雑誌   33 ( 3 )   620 - 620   2015年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • Survival outcome of stage I ovarian clear cell carcinoma with lympho-vascular space invasion 査読

    Koji Matsuo, Kiyoshi Yoshino, Kosei Hasegawa, Ryusuke Murakami, Yuji Ikeda, Sosuke Adachi, Kosuke Hiramatsu, Takuhei Yokoyama, Masato Nishimura, Todd B. Sheridan, Takayuki Enomoto, Keiichi Fujiwara, Noriomi Matsumura, Ikuo Konishi, Christina Fotopoulou, Lynda D. Roman, Anil K. Sood

    GYNECOLOGIC ONCOLOGY   136 ( 2 )   198 - 204   2015年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Background. The clinical impact of lympho-vascular space invasion (LVSI) in early-stage ovarian clear cell carcinoma (OCCC) is not well understood. Given the distinct tumor biology and survival patterns of OCCC, the significance of LVSI on survival outcome and treatment response was examined in OCCC.
    Methods. A multicenter study was conducted to examine stage IA-IC3 OCCC cases that underwent primary surgical staging including lymphadenectomy. LVSI status was determined from archived histopathology slides, correlated with clinico-pathological results, chemotherapy patterns, and survival outcomes.
    Results. LVSI was observed in 47 (20.3%) among 232 cases. In univariate analysis, LVSI was associated with older age (p = 0.042), large tumor size (p = 0.048), and stage IC (p = 0.035). In survival analysis, LVSI was associated with decreased disease-free survival (DFS, 5-year rate, 70.6% versus 92.1%, p = 0.0004) and overall survival (OS, 78.8% versus 93.3%, p = 0.008) on univariate analysis. After controlling for age, tumor size, stage, and chemotherapy use, LVSI remained an,independent prognostic factor for decreased survival outcomes (DFS, hazard ratio [HR] 4.35, 95% confidence interval [CI] 1.73-10.9, p = 0.002; and OS, HR 4.73, 95%CI 1.60-14.0, p = 0.015). Among 210 cases who received postoperative chemotherapy, while regimen type did not impact survival outcome regardless of LVSI status (DFS, p = 0.63), the number of administered cycles showed a survival benefit towards cycles for patients with LVSI-positive tumors (DFS, p = 0.009; and OS, p = 0.016).
    Conclusion. LVSI is an important marker to predict survival outcome of stage I OCCC. Regardless of chemotherapy type, patients with stage I OCCC showing LVSI may benefit from receiving postoperative chemotherapy. (C) 2014 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.ygyno.2014.12.006

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  • Identification of novel exonic mobile element insertions in epithelial ovarian cancers. 査読 国際誌

    Hayano T, Yamada S, Hosomichi K, Nakaoka H, Yoshihara K, Adachi S, Kashima K, Tanaka K, Enomoto T, Inoue I

    Hum Genome Var.   2   15030 - 15030   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/hgv.2015.30

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  • Molecular characterization of an intact p53 pathway subtype in high-grade serous ovarian cancer. 査読 国際誌

    Takahide Hayano, Yuki Yokota, Kazuyoshi Hosomichi, Hirofumi Nakaoka, Kosuke Yoshihara, Sosuke Adachi, Katsunori Kashima, Hitoshi Tsuda, Takuya Moriya, Kenichi Tanaka, Takayuki Enomoto, Ituro Inoue

    PloS one   9 ( 12 )   e114491   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    High-grade serous ovarian cancer (HGSOC) is the most aggressive histological type of epithelial ovarian cancer, which is characterized by a high frequency of somatic TP53 mutations. We performed exome analyses of tumors and matched normal tissues of 34 Japanese patients with HGSOC and observed a substantial number of patients without TP53 mutation (24%, 8/34). Combined with the results of copy number variation analyses, we subdivided the 34 patients with HGSOC into subtypes designated ST1 and ST2. ST1 showed intact p53 pathway and was characterized by fewer somatic mutations and copy number alterations. In contrast, the p53 pathway was impaired in ST2, which is characterized by abundant somatic mutations and copy number alterations. Gene expression profiles combined with analyses using the Gene Ontology resource indicate the involvement of specific biological processes (mitosis and DNA helicase) that are relevant to genomic stability and cancer etiology. In particular we demonstrate the presence of a novel subtype of patients with HGSOC that is characterized by an intact p53 pathway, with limited genomic alterations and specific gene expression profiles.

    DOI: 10.1371/journal.pone.0114491

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  • 初期子宮体癌に対する腹腔鏡下根治手術 複数術者によるfeasibilityと予後の検討 査読

    安達聡介, 八幡哲郎, 工藤梨沙, 山岸葉子, 山脇芳, 須田一暁, 田村亮, 茅原誠, 南川高廣, 萬歳千秋, 西野幸治, 西川伸道, 加嶋克則, 榎本隆之

    日本産科婦人科内視鏡学会雑誌   2013年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.5180/jsgoe.29.313

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  • A nonsynonymous variant of IL1A is associated with endometriosis in Japanese population. 査読 国際誌

    Yuki Hata, Hirofumi Nakaoka, Kosuke Yoshihara, Sosuke Adachi, Kazufumi Haino, Masayuki Yamaguchi, Nobumichi Nishikawa, Katsunori Kashima, Tetsuro Yahata, Atsushi Tajima, Atsushi Watanabe, Shigeo Akira, Kazuyoshi Hosomichi, Ituro Inoue, Kenichi Tanaka

    Journal of human genetics   58 ( 8 )   517 - 20   2013年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Our previous genome-wide association study has demonstrated that single-nucleotide polymorphisms (SNPs) located in intronic and downstream regions of IL1A (interleukin 1α) were associated with the risk of endometriosis. These SNPs on the genome-wide association study platform could be only surrogates for the true causal variant. Thus, we resequenced all the exons of IL1A in 377 patients with endometriosis and 457 healthy controls. We detected seven rare variants (minor allele frequency <0.01) and four common variants. All the rare variants were not associated with endometriosis. The four common variants (rs17561, rs1304037, rs2856836 and rs3783553) in IL1A were significantly associated with endometriosis (P=0.0024, 0.0024, 0.0014 and 0.0061, respectively). All the four SNPs were within a linkage disequilibrium block. Among them, only rs17561 was nonsynonymous (p.A114S), which has been reported to be associated with susceptibility to ovarian cancer. Taken together, we examined association between rs17561 and endometriosis in an independent validation data set (524 patients and 533 healthy controls) replicating significant association (P=4.0 × 10(-5); odds ratio (OR), 1.91; 95% confidence interval (CI), 1.41-2.61). Meta-analysis by combining results from the two stages strengthened the evidence of association (P=2.5 × 10(-7); OR, 1.90; 95% CI, 1.49-2.43). Our findings demonstrated that the nonsynonymous variant of IL1A might confer genetic susceptibility to endometriosis in Japanese population.

    DOI: 10.1038/jhg.2013.32

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  • Genome-wide association meta-analysis identifies new endometriosis risk loci. 国際誌

    Dale R Nyholt, Siew-Kee Low, Carl A Anderson, Jodie N Painter, Satoko Uno, Andrew P Morris, Stuart MacGregor, Scott D Gordon, Anjali K Henders, Nicholas G Martin, John Attia, Elizabeth G Holliday, Mark McEvoy, Rodney J Scott, Stephen H Kennedy, Susan A Treloar, Stacey A Missmer, Sosuke Adachi, Kenichi Tanaka, Yusuke Nakamura, Krina T Zondervan, Hitoshi Zembutsu, Grant W Montgomery

    Nature genetics   44 ( 12 )   1355 - 9   2012年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We conducted a genome-wide association meta-analysis of 4,604 endometriosis cases and 9,393 controls of Japanese and European ancestry. We show that rs12700667 on chromosome 7p15.2, previously found to associate with disease in Europeans, replicates in Japanese (P = 3.6 × 10(-3)), and we confirm association of rs7521902 at 1p36.12 near WNT4. In addition, we establish an association of rs13394619 in GREB1 at 2p25.1 with endometriosis and identify a newly associated locus at 12q22 near VEZT (rs10859871). Excluding cases of European ancestry of minimal or unknown severity, we identified additional previously unknown loci at 2p14 (rs4141819), 6p22.3 (rs7739264) and 9p21.3 (rs1537377). All seven SNP effects were replicated in an independent cohort and associated at P <5 × 10(-8) in a combined analysis. Finally, we found a significant overlap in polygenic risk for endometriosis between the genome-wide association cohorts of European and Japanese descent (P = 8.8 × 10(-11)), indicating that many weakly associated SNPs represent true endometriosis risk loci and that risk prediction and future targeted disease therapy may be transferred across these populations.

    DOI: 10.1038/ng.2445

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  • Possible involvement of the E-cadherin gene in genetic susceptibility to endometriosis 査読

    Kunihiko Yoshida, Kosuke Yoshihara, Sosuke Adachi, Kazufumi Haino, Koji Nishino, Masayuki Yamaguchi, Nobumichi Nishikawa, Katsunori Kashima, Tetsuro Yahata, Hideaki Masuzaki, Hidetaka Katabuchi, Kenichiro Ikuma, Hiroshi Suginami, Kenichi Tanaka

    HUMAN REPRODUCTION   27 ( 6 )   1685 - 1689   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    Endometriotic cells display invasive characteristics, despite their benign histological appearance. Recently, the epithelialmesenchymal transition, in which epithelial cells acquire mesenchymal and migratory properties, has attracted attention as a mechanism of tumor invasion. We aimed to investigate the association between endometriosis and polymorphisms of the E-cadherin gene, a central player in the epithelialmesenchymal transition, in Japanese women.
    Twelve single-nucleotide polymorphisms (SNPs) in the E-cadherin gene were identified by real-time polymerase chain reaction using a TaqMan assay in 511 women with endometriosis (the majority in Stages III and IV) and 498 healthy controls.
    Allele frequency analysis indicated that there was a marginally higher frequency of the rs4783689 C allele in women with endometriosis compared with controls (corrected P 0.007; odds ratio 1.37; 95 confidence interval, 1.141.64). No significant associations with endometriosis were found for the other 11 SNPs.
    Although this study was limited by sample size, the E-cadherin gene polymorphism rs4783689 was marginally associated with endometriosis in the Japanese population, suggesting that E-cadherin might be involved in genetic susceptibility to endometriosis.

    DOI: 10.1093/humrep/des080

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  • Germline Copy Number Variations in BRCA1-Associated Ovarian Cancer Patients 査読

    Kosuke Yoshihara, Atsushi Tajima, Sosuke Adachi, Jinhua Quan, Masayuki Sekine, Hiroaki Kase, Tetsuro Yahata, Ituro Inoue, Kenichi Tanaka

    GENES CHROMOSOMES & CANCER   50 ( 3 )   167 - 177   2011年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-LISS  

    We investigated characteristics of germline copy number variations (CNV) in BRCA1-associated ovarian cancer patients by comparing them to CNVs present in sporadic ovarian cancer patients. Germline CNVs in 51 BRCA1-associated, 33 sporadic ovarian cancer patients, and 47 healthy women were analyzed by both signal intensity and genotyping data using the Affymetrix Genome-Wide Human SNP Array 6.0. The total number of CNVs per genome was greater in the sporadic group (median 26, range 12-34) than in the BRCA1 group (median 21, range 11-35; post hoc P &lt; 0.05) or normal group (median 20, range 7-32; post hoc P &lt; 0.05). While the number of amplifications per genome was higher in the sporadic group (median 13, range 7-26) than in the BRCA1 group (median 8, range 3-23; post hoc P &lt; 0.001), the number of deletions per genome was higher in the BRCA1 group (median 12, range 6-24) than in the sporadic group (median 9, range 3 17; post hoc P &lt; 0.01). In addition, 31 previously unknown CNV regions were present specifically in the BRCA1 group. When we performed pathway analysis on the 241 overlapping genes mapped to these novel CNV regions, the &apos;purine metabolism&apos; and &apos;14-3-3-mediated signaling&apos; pathways were over-represented (Fisher&apos;s exact test, P &lt; 0.01). Our study shows that there are qualitative differences in genomic CNV profiles between BRCA1-associated and sporadic ovarian cancer patients. Further studies are necessary to clarify the significance of the genomic CNV profile unique to BRCA1-associated ovarian cancer patients. (C) 2010 Wiley-Liss, Inc.

    DOI: 10.1002/gcc.20841

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  • Identification of Receptor Tyrosine Kinase, Discoidin Domain Receptor 1 (DDR1), as a Potential Biomarker for Serous Ovarian Cancer 査読

    Jinhua Quan, Tetsuro Yahata, Sosuke Adachi, Kosuke Yoshihara, Kenichi Tanaka

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   12 ( 2 )   971 - 982   2011年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI AG  

    Ovarian cancer, one of the most common gynecological malignancies, has an aggressive phenotype. It is necessary to develop novel and more effective treatment strategies against advanced disease. Protein tyrosine kinases (PTKs) play an important role in the signal transduction pathways involved in tumorigenesis, and represent potential targets for anticancer therapies. In this study, we performed cDNA subtraction following polymerase chain reaction (PCR) using degenerate oligonucleotide primers to identify specifically overexpressed PTKs in ovarian cancer. Three PTKs, janus kinase 1, insulin-like growth factor 1 receptor, and discoidin domain receptor 1 (DDR1), were identified and only DDR1 was overexpressed in all ovarian cancer tissues examined for the validation by quantitative real-time PCR. The DDR1 protein was expressed in 63% (42/67) of serous ovarian cancer tissue, whereas it was undetectable in normal ovarian surface epithelium. DDR1 was expressed significantly more frequently in high-grade (79%) and advanced stage (77%) tumors compared to low-grade (50%) and early stage (43%) tumors. The expression of the DDR1 protein significantly correlated with poor disease-free survival. Although its functional role and clinical utility remain to be examined in future studies, our results suggest that the expression of DDR1 may serve as both a potential biomarker and a molecular target for advanced ovarian cancer.

    DOI: 10.3390/ijms12020971

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  • Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population 査読

    Sosuke Adachi, Atsushi Tajima, Jinhua Quan, Kazufumi Haino, Kosuke Yoshihara, Hideaki Masuzaki, Hidetaka Katabuchi, Kenichiro Ikuma, Hiroshi Suginami, Nao Nishida, Ryozo Kuwano, Yuji Okazaki, Yoshiya Kawamura, Tsukasa Sasaki, Katsushi Tokunaga, Ituro Inoue, Kenichi Tanaka

    JOURNAL OF HUMAN GENETICS   55 ( 12 )   816 - 821   2010年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATURE PUBLISHING GROUP  

    To identify susceptibility genes for endometriosis in Japanese women, genome-wide association (GWA) analysis was performed using two case-control cohorts genotyped with the Affymetrix Mapping 500K Array or Genome-Wide Human SNP Array 6.0. In each of the two array cohorts, stringent quality control (QC) filters were applied to newly obtained genotype data, together with previously analyzed data from the Japanese Integrated Database Project. After QC-based filtering of samples and single nucleotide polymorphisms (SNPs) in each cohort, 282 838 SNPs in both genotyping platforms were tested for association with endometriosis using a meta-analysis of the two GWA studies with 696 patients with endometriosis and 825 controls. The meta-analysis revealed that a common susceptibility locus conferring a large effect on the disease risk was unlikely. On the other hand, an excess of SNPs with P-values &lt;10(-4) (36 vs 28 SNPs expected by chance) was observed in the meta-analysis. Of note, four of the top five SNPs with P-values &lt;10(-5) were located in and around IL1A (interleukin 1 alpha), which might be a functional candidate gene for endometriosis. Further studies with larger case-control cohorts will be necessary to elucidate the genetic risk factors. Journal of Human Genetics (2010) 55, 816-821; doi:10.1038/jhg.2010.118; published online 16 September 2010

    DOI: 10.1038/jhg.2010.118

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  • Serum leptin-adiponectin ratio and endometrial cancer risk in postmenopausal female subjects 査読

    Naohiro Ashizawa, Tetsuro Yahata, Jinhua Quan, Sosuke Adachi, Kosuke Yoshihara, Kenichi Tanaka

    GYNECOLOGIC ONCOLOGY   119 ( 1 )   65 - 69   2010年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    Objective. Obesity is a well-known risk factor for the development of endometrial cancer. Elevated endogenous estrogen and insulin resistance are recognized to be major factors that link obesity and cancer development. However, there is increasing evidence that the adipokines adiponectin and leptin, which are directly produced in adipose tissue, impact several obesity-related cancers. The purpose of the current study was to investigate the relationships of the concentration of leptin, adiponectin, and the leptin-to-adiponectin ratio (L/A ratio) with the endometrial cancer risk in postmenopausal female subjects.
    Methods. A case-control study was performed in 146 postmenopausal female subjects with endometrial cancer and 150 control subjects with no history of cancer. The serum levels of the adipokines leptin and adiponectin were measured, and the associations of these adipokines and the L/A ratios with the endometrial cancer risk were analyzed.
    Results. The leptin levels and the L/A ratios were significantly higher in the incident cases of endometrial cancer (8.2 +/- 0.5, 2.05 +/- 1.08 ng/ml) than in the controls subjects (4.5 +/- 0.5, 0.98 +/- 0.18, P&lt;0.0001), whereas the adiponectin levels were significantly lower in the incident cases (6.2 +/- 0.4 mu g/ml) than in the control subjects (9.0 +/- 0.4 mu g/ml, P&lt;0.0001). For the incident cases, the serum levels of the adipokines were significantly correlated with the patient body mass index (BMI) (P&lt;0.001 for leptin, P&lt;0.05 for adiponectin), and the leptin levels and the L/A ratios were significantly correlated with the homeostasis model assessment ratio (HOMA-R) and the fasting insulin levels (P&lt;.001). Higher L/A ratios were found to be significantly associated with an increased risk of endometrial cancer [OR (95% Cl) for the top vs. the bottom tertile of the L/A ratio was 6.0 (3.2-11.9), P-value&lt;0.0001]. Moreover, the ORs of the L/A ratios were higher than those of leptin or adiponectin alone. The association of the L/A ratios with endometrial cancer risk remained after adjusting for the obesity indices, hypertension, and presence of diabetes mellitus.
    Conclusion. The present results suggested that the L/A ratio was independently associated with an increased risk for endometrial cancer development. Additional research will elucidate the molecular mechanisms by which these adipokines are associated with the development of endometrial cancer. (C) 2010 Published by Elsevier Inc.

    DOI: 10.1016/j.ygyno.2010.07.007

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MISC

  • 女性の家族性がん 新潟県におけるHBOC診療体制の確立に向けての取り組み

    西野 幸治, 須田 一暁, 安達 聡介, 吉原 弘祐, 関根 正幸, 榎本 隆之, 五十嵐 真由子, 土田 純子, 中島 真人, 永橋 昌幸, 田澤 立之, 栗山 洋子, 藤田 沙織里, 小山 諭, 菊池 朗, 佐藤 信昭, 金子 耕司, 田村 恵美子, 三富 亜希, 後藤 清恵

    人間ドック   33 ( 2 )   232 - 232   2018年8月

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    記述言語:日本語   出版者・発行元:(公社)日本人間ドック学会  

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  • 腹腔鏡による迅速な診断が可能であった悪性リンパ腫の一例

    西野 幸治, 安達 聡介, 明石 英彦, 工藤 梨沙, 茅原 誠, 石黒 竜也, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   34 ( Suppl.I )   202 - 202   2018年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 機能性子宮体部を持つ先天性腟・頸管欠損症に対する腹腔鏡下広汎頸部摘出術を応用した腹腔鏡下形成手術

    小林 暁子, 磯部 真倫, 上田 遥香, 工藤 梨沙, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   34 ( Suppl.I )   399 - 399   2018年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 機能性単角子宮を伴う先天性腟閉鎖に対する腹腔鏡下頸管形成造腟術を施行した1例

    小林 暁子, 磯部 真倫, 上田 遥香, 工藤 梨沙, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    産婦人科手術   ( 29 )   165 - 165   2018年6月

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    記述言語:日本語   出版者・発行元:(株)メジカルビュー社  

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  • 新潟県におけるHBOC診療の取り組み

    西野 幸治, 須田 一暁, 安達 聡介, 吉原 弘祐, 関根 正幸, 榎本 隆之, 菊池 朗

    日本産科婦人科学会雑誌   70 ( 2 )   685 - 685   2018年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 2歳女児の腟内異物の一症例

    上田 遥香, 茅原 誠, 磯部 真倫, 山口 真奈子, 小木 幹奈, 工藤 梨沙, 石黒 竜也, 安達 聡介, 吉原 弘祐, 小林 暁子, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   112 ( 2 )   99 - 99   2017年12月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 当院における前回帝王切開症例の膀胱挙上、癒着に対する剥離の工夫

    小林 暁子, 磯部 真倫, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   1501 - 1501   2017年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 当科で経験した腹腔鏡手術中における器具破損・紛失症例について

    安達 聡介, 磯部 真倫, 上田 遥香, 茅原 誠, 石黒 竜也, 郷戸 千賀子, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   112 ( 1 )   48 - 48   2017年8月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 先進医療「腹腔鏡下広汎子宮全摘術」施設認定の報告

    磯部 真倫, 上田 遥香, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 小林 暁子, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   112 ( 1 )   43 - 43   2017年8月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 癌性腹膜炎との鑑別に腹腔鏡下生検が有用であった結核性腹膜炎の2例

    上田 遥香, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 郷戸 千賀子, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   1460 - 1460   2017年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 当科で経験した腹腔鏡手術中における器具破損・紛失症例について

    安達 聡介, 磯部 真倫, 上田 遥香, 工藤 梨沙, 茅原 誠, 石黒 竜也, 吉原 弘祐, 小林 暁子, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   1153 - 1153   2017年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 深化 TLHこんな時どうする 教育、普及する側から見たTLH難症例への対応

    磯部 真倫, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   33 ( Suppl.I )   358 - 358   2017年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 進行卵巣癌に対する腹腔鏡生検の意義

    谷地田 希, 西野 幸治, 安達 聡介, 上田 遥香, 工藤 梨沙, 茅原 誠, 石黒 竜也, 郷戸 千賀子, 吉原 弘祐, 小林 暁子, 西川 伸道, 関根 正幸, 榎本 隆之

    日本婦人科腫瘍学会雑誌   35 ( 3 )   553 - 553   2017年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 卵巣癌に対するベバシズマブ投与後の手術は安全に施行可能か?

    西野 幸治, 上田 遥香, 茅原 誠, 石黒 竜也, 安達 聡介, 郷戸 千賀子, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西川 伸道, 関根 正幸, 榎本 隆之

    日本婦人科腫瘍学会雑誌   35 ( 3 )   634 - 634   2017年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 癌性腹膜炎が疑われた結核性腹膜炎の2症例

    安達 聡介, 上田 遥香, 工藤 梨沙, 茅原 誠, 石黒 竜也, 郷戸 千賀子, 吉原 弘祐, 磯部 真倫, 小林 暁子, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本婦人科腫瘍学会雑誌   35 ( 3 )   614 - 614   2017年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 腹腔鏡下付属器手術後に境界悪性あるいは悪性卵巣腫瘍と診断された9例の検討

    小林 暁子, 茅原 誠, 石黒 竜也, 安達 聡介, 郷戸 千賀子, 吉原 弘祐, 磯部 真倫, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本婦人科腫瘍学会雑誌   35 ( 3 )   596 - 596   2017年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 完全型アンドロゲン不応症に対し腹腔鏡下性腺摘出術を施行した症例の検討

    茅原 誠, 安達 聡介, 谷地田 希, 田村 亮, 石黒 竜也, 吉田 邦彦, 吉原 弘祐, 磯部 真倫, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   111 ( 2 )   84 - 88   2016年12月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

    完全型アンドロゲン不応症(AIS)に対し腹腔鏡下性腺摘出術を施行した4例について検討した。年齢は16歳が2例、19歳が2例であった。性腺が鼠径管内に存在した1例も含めて、全例で腹腔鏡下に性腺摘出が可能であった。全例、術後経過は良好で、外来通院にてエストロゲン補充療法中である。今回の検討から、術前画像診断(特にMRI所見)により性腺の存在位置を予測し、鼠径管内に存在が疑われる場合には開腹手術への移行に備えることで、腹腔鏡下手術をAISに対する予防的性腺摘出術に適応することが可能であると考えられた。

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  • 卵巣 卵巣がんに対する抗がん剤治療 卵巣癌に対するベバシズマブの投与状況 著効例の提示と今後の課題

    西野 幸治, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 郷戸 千賀子, 吉原 弘祐, 磯部 真倫, 西川 伸道, 関根 正幸, 榎本 隆之

    日本癌治療学会学術集会抄録集   54回   WS55 - 5   2016年10月

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    記述言語:日本語   出版者・発行元:(一社)日本癌治療学会  

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  • 子宮頸癌と結腸癌の重複傍大動脈リンパ節転移を呈した1例

    杉野 健太郎, 関根 正幸, 工藤 梨沙, 島 英里, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西野 幸治, 西川 伸道, 榎本 隆之

    日本癌治療学会学術集会抄録集   54回   P17 - 4   2016年10月

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    記述言語:日本語   出版者・発行元:(一社)日本癌治療学会  

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  • 医師の人材育成における「メンター制度」の有効性 新潟県における腹腔鏡手術の教育から得たもの

    磯部 真倫, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   64回   147 - 147   2016年9月

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    記述言語:日本語   出版者・発行元:東北連合産科婦人科学会・北日本産科婦人科学会  

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  • 当科における胞状奇胎症例の後方視的検討

    森 裕太郎, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   64回   158 - 158   2016年9月

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    記述言語:日本語   出版者・発行元:東北連合産科婦人科学会・北日本産科婦人科学会  

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  • 腹腔鏡下卵巣腫瘍摘出術術後血腫感染に対して腹腔鏡下ドレナージを施行した1例

    杉野 健太郎, 磯部 真倫, 工藤 梨沙, 島 英里, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   32 ( Suppl.I )   216 - 216   2016年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 腹腔鏡下に腫大リンパ節を摘出後、迅速診断でリンパ節転移陽性と診断し、開腹による根治術を施行したMPA療法後子宮体癌の一例

    茅原 誠, 西野 幸治, 磯部 真倫, 島 英里, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   32 ( Suppl.I )   206 - 206   2016年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 骨盤腹腔鏡手術の若手教育 地方における腹腔鏡手術の教育、普及をいかに行うか? 腹腔鏡に関連した地域全体での「メンター制度」の有効性

    磯部 真倫, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   32 ( Suppl.I )   118 - 118   2016年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • 腹腔鏡下リンパ節生検が診断に有用であった原発不明癌の一例

    吉原 弘祐, 磯部 真倫, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   32 ( Suppl.I )   304 - 304   2016年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • BMI40以上の高度肥満3症例に対する腹腔鏡手術の経験

    西野 幸治, 磯部 真倫, 工藤 梨沙, 島 英里, 茅原 誠, 石黒 竜也, 安達 聡介, 郷戸 千賀子, 吉原 弘祐, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   32 ( Suppl.I )   241 - 241   2016年8月

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    記述言語:日本語   出版者・発行元:(一社)日本産科婦人科内視鏡学会  

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  • Identification of novel kinase fusion transcripts in endometrial cancer

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    CANCER RESEARCH   76   2016年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER ASSOC CANCER RESEARCH  

    DOI: 10.1158/1538-7445.AM2016-1504

    Web of Science

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  • 当科における腹腔鏡下準広汎子宮全摘術の工夫

    磯部 真倫, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   111 ( 1 )   51 - 51   2016年7月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 腹腔鏡下卵巣腫瘍摘出術 術後血腫感染に対して腹腔鏡下ドレナージを施行した1例

    杉野 健太郎, 磯部 真倫, 工藤 梨沙, 島 英里, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   111 ( 1 )   48 - 48   2016年7月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 新潟大学と関連病院における腹腔鏡手術教育の現況(その2) 関連病院全体での安全な手術の普及を目指して

    磯部 真倫, 杉野 健太郎, 山口 真奈子, 島 英里, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   111 ( 1 )   37 - 37   2016年7月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

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  • 婦人科悪性腫瘍手術の周術期予防的抗菌薬投与について

    西川 伸道, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西野 幸治, 関根 正幸, 榎本 隆之

    新潟産科婦人科学会会誌   111 ( 1 )   26 - 28   2016年7月

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    記述言語:日本語   出版者・発行元:新潟産科婦人科学会  

    婦人科悪性腫瘍手術の周術期予防的抗菌薬投与について検討した。開腹による悪性腫瘍根治術を施行し、術後の抗生剤を使用せず周術期のみセファゾリン(CEZ)を使用した140例を対象とした。手術部位感染(SSI)を発症した感染例6例、非感染例134例であった。6例でSSIを認めたが、6時間以上の手術20例では3例でSSIを発症した。術後1日目のCRP値は、感染群で高値の傾向があった。発症率は、腸管切除施行83%、施行していない32%であったが、有意差を認めなかった。抗菌剤投与が適正に行われていた60例中1例、適正投与されなかった44例中3例でSSIを発症していたが、有意差は認めなかった。腸管切除を施行した12例のうち8例に3時間毎の適正な抗菌剤投与が施行された。

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  • 当科の過去9年間で治療した子宮頸癌I・II期の治療成績について

    西川 伸道, 吉原 弘祐, 島 英里, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 磯部 真倫, 西野 幸治, 関根 正幸, 榎本 隆之

    日本婦人科腫瘍学会雑誌   34 ( 3 )   435 - 435   2016年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 卵巣成熟奇形腫内の呼吸上皮の腸上皮化生から発生した粘液性癌の一例

    工藤 梨沙, 吉原 弘祐, 西野 幸治, 谷地田 希, 島 英里, 茅原 誠, 石黒 竜也, 安達 聡介, 磯部 真倫, 西川 伸道, 関根 正幸, 榎本 隆之

    日本婦人科腫瘍学会雑誌   34 ( 3 )   526 - 526   2016年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 肝細胞癌あるいは肝様癌との鑑別に苦慮した再発を繰り返す卵巣未分化癌の一例

    市川 希, 石黒 竜也, 西野 幸治, 工藤 梨沙, 島 英里, 茅原 誠, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西川 伸道, 関根 正幸, 榎本 隆之

    日本婦人科腫瘍学会雑誌   34 ( 3 )   525 - 525   2016年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 腹腔鏡下に摘出した卵巣Sertoli-Leydig cell tumorの2症例

    磯部 真倫, 山口 真奈子, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本婦人科腫瘍学会雑誌   34 ( 3 )   517 - 517   2016年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 当院における卵巣癌に対するベバシズマブの使用状況 著効例の提示と今後の課題を踏まえて

    西野 幸治, 谷地田 希, 工藤 梨沙, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西川 伸道, 関根 正幸, 榎本 隆之

    日本婦人科腫瘍学会雑誌   34 ( 3 )   441 - 441   2016年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 子宮頸癌に対する広汎子宮全摘後の腸閉塞と術後補助放射線療法についての検討

    西野 幸治, 山口 真奈子, 杉野 健太郎, 工藤 梨沙, 石黒 竜也, 安達 聡介, 吉原 弘祐, 五日市 美奈, 磯部 真倫, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科学会雑誌   68 ( 2 )   696 - 696   2016年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 難症例に対する腹腔鏡下子宮全摘術 剥離層にこだわる

    磯部 真倫, 杉野 健太郎, 山口 真奈子, 森 裕太郎, 工藤 梨沙, 石黒 竜也, 安達 聡介, 吉原 弘祐, 五日市 美奈, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之, 南川 高廣

    新潟産科婦人科学会会誌   110 ( 2 )   96 - 96   2015年12月

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  • 新潟大学における腹腔鏡手術教育の現況(その2) 関連病院全体での安全な腹腔鏡手術の普及を目指して

    磯部 真倫, 安達 聡介, 吉原 弘祐, 藤原 和子, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集   63回   111 - 111   2015年9月

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    記述言語:日本語   出版者・発行元:東北連合産科婦人科学会・北日本産科婦人科学会  

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  • BMI40の高度肥満を合併するダグラス窩閉鎖子宮内膜症に腹腔鏡手術が有用であった一例

    西野 幸治, 磯部 真倫, 森 裕太郎, 工藤 梨沙, 茅原 誠, 吉田 邦彦, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   31 ( Suppl.I )   164 - 164   2015年8月

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  • 当院における腹腔鏡下子宮体癌手術の成績 開腹手術との比較検討

    磯部 真倫, 茅原 誠, 石黒 竜也, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   31 ( Suppl.I )   247 - 247   2015年8月

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  • 新潟大学とその関連病院における腹腔鏡手術教育の現況 関連病院全体での安全な腹腔鏡手術の普及を目指して

    磯部 真倫, 高木 偉博, 安達 聡介, 吉原 弘祐, 藤原 和子, 西野 幸治, 西川 伸道, 関根 正幸, 榎本 隆之

    日本産科婦人科内視鏡学会雑誌   31 ( Suppl.I )   207 - 207   2015年8月

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  • 当院における腹腔鏡下子宮体癌手術の成績 開腹手術との比較検討

    磯部 真倫, 茅原 誠, 石黒 竜也, 吉田 邦彦, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 芹川 武大, 関根 正幸, 加嶋 克則, 榎本 隆之

    日本婦人科腫瘍学会雑誌   33 ( 3 )   599 - 599   2015年6月

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    記述言語:日本語   出版者・発行元:(公社)日本婦人科腫瘍学会  

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  • 妊娠を契機に診断されたUpshaw-Schulman症候群症例における第二子妊娠の周産期管理

    森山 雅人, 玉木 悦子, 松本 雅則, 石西 綾美, 松本 吉史, 冨永 麻理恵, 工藤 理沙, 安達 聡介, 生野 寿史, 高桑 好一, 宮腰 淑子, 小堺 貴司, 小林 弘典, 牛木 隆志, 柴崎 康彦, 増子 正義, 瀧澤 淳, 成田 美和子, 曽根 博仁, 西條 康夫

    日本血栓止血学会誌   26 ( 2 )   193 - 193   2015年4月

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  • 子宮体癌における卵巣転移のリスク因子に関する検討

    戸田 紀夫, 加嶋 克則, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西野 幸治, 西川 伸道, 芹川 武大, 関根 正幸, 榎本 隆之

    日本産科婦人科学会雑誌   67 ( 2 )   680 - 680   2015年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 当院における腹腔鏡下子宮体癌手術の成績 開腹手術との比較検討

    磯部 真倫, 吉田 邦彦, 安達 聡介, 吉原 弘祐, 西野 幸治, 西川 伸道, 関根 正幸, 芹川 武大, 加嶋 克則, 榎本 隆之

    日本産科婦人科学会雑誌   67 ( 2 )   842 - 842   2015年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • P2-11-6 子宮体癌における卵巣転移のリスク因子に関する検討(Group52 子宮体部腫瘍 予後,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

    戸田 紀夫, 加嶋 克則, 安達 聡介, 吉原 弘祐, 磯部 真倫, 西野 幸治, 西川 伸道, 芹川 武大, 関根 正幸, 榎本 隆之

    日本産科婦人科學會雜誌   67 ( 2 )   680 - 680   2015年

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    記述言語:日本語   出版者・発行元:日本産科婦人科学会  

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  • P3-47-3 子宮筋腫核出術の妊娠・分娩への影響について(Group 149 合併症妊娠12,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

    安達 聡介, 能 伸太郎, 冨永 麻理恵, 工藤 梨沙, 松本 賢典, 佐藤 ひとみ, 能仲 智加, 生野 寿史, 山口 雅幸, 高桑 好一, 榎本 隆之

    日本産科婦人科學會雜誌   67 ( 2 )   944 - 944   2015年

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    記述言語:日本語   出版者・発行元:日本産科婦人科学会  

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    その他リンク: https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=455199

  • P3-47-7 既往子宮手術による子宮筋層欠損を伴った3妊娠症例(Group 149 合併症妊娠12,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

    山口 雅幸, 冨永 麻理恵, 工藤 梨沙, 松本 賢典, 能仲 智加, 佐藤 ひとみ, 安達 聡介, 能仲 太郎, 榎本 隆之, 生野 寿史, 高桑 好一

    日本産科婦人科學會雜誌   67 ( 2 )   945 - 945   2015年

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    記述言語:日本語   出版者・発行元:日本産科婦人科学会  

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  • ISP-4-1 Integrated analysis of high-grade serous ovarian cancer revealed two subtypes related to p53 signaling pathway(Group 4 Oncology 4,IS Poster,International Session) :

    Suda Kazuaki, Yokota Yuki, Yoshihara Kosuke, Adachi Sosuke, Kashima Katsunori, Tanaka Kenichi, Enomoto Takayuki

    日本産科婦人科學會雜誌   67 ( 2 )   1012 - 1012   2015年

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    記述言語:英語   出版者・発行元:日本産科婦人科学会  

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  • 動静脈瘻との鑑別が困難であった絨毛癌

    関塚智之, 芹川武大, 安達聡介, 磯部真倫, 関根正幸, 加嶋克則, 榎本隆之

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集(Web)   62nd   2014年

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  • P2-11-7 血性帯下を契機に診断された腟原発ブドウ状肉腫の1例(Group49 腟・外陰癌,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)

    山岸 葉子, 横田 有紀, 南川 高廣, 安達 聡介, 関根 正幸, 八幡 哲郎, 榎本 隆之

    日本産科婦人科學會雜誌   66 ( 2 )   614 - 614   2014年

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    記述言語:日本語   出版者・発行元:日本産科婦人科学会  

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    その他リンク: https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=452390

  • P3-11-8 後腹膜リンパ節郭清を含む卵巣癌の術後に,腎動脈血栓症による腎梗塞を発症した1例(Group 116 卵巣腫瘍・診断・治療(症例)1,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)

    島 英里, 南川 高廣, 須田 一暁, 安達 聡介, 西野 幸治, 西川 伸道, 加嶋 克則, 八幡 哲郎, 榎本 隆之

    日本産科婦人科學會雜誌   65 ( 2 )   887 - 887   2013年

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    記述言語:日本語   出版者・発行元:日本産科婦人科学会  

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    その他リンク: https://projects.repo.nii.ac.jp/?action=repository_uri&item_id=450994

  • 子宮内膜症の遺伝的関与 子宮内膜症疾患感受性遺伝子の同定

    安達 聡介, 畑 有紀, 吉原 弘祐, 田中 憲一

    日本エンドメトリオーシス学会会誌   33   102 - 102   2012年7月

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    記述言語:日本語   出版者・発行元:日本エンドメトリオーシス学会  

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  • 無精子症と遺伝子多型との関連解析

    茅原 誠, 吉原 弘祐, 安達 聡介, 田中 憲一

    日本産科婦人科学会雑誌   64 ( 2 )   582 - 582   2012年2月

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  • P1-13-3 婦人科悪性腫瘍患者における化学療法後の悪心・嘔吐に対するパロノセトロンの有用性の検討(Group13 婦人科腫瘍全般・症例5,一般演題,第64回日本産科婦人科学会学術講演会)

    安達 聡介, 萬歳 千秋, 西野 幸治, 山口 雅幸, 西川 伸道, 加嶋 克則, 藤田 和之, 八幡 哲郎, 田中 憲一

    日本産科婦人科學會雜誌   64 ( 2 )   458 - 458   2012年

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  • 子宮体癌の発癌・進展機構 血清レプチン/アディポネクチン比と子宮体癌発症リスク

    芦澤 直浩, 八幡 哲郎, 安達 聡介, 吉原 弘祐, 田中 憲一

    日本婦人科腫瘍学会雑誌   29 ( 3 )   498 - 498   2011年6月

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  • 上皮性卵巣癌組織におけるCopy Neutral LOH領域の解析

    安達 聡介, 吉原 弘祐, 田中 憲一

    日本婦人科腫瘍学会雑誌   29 ( 3 )   551 - 551   2011年6月

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  • BRCA1変異陽性卵巣癌患者における胚細胞性コピー数多型プロファイル

    吉原 弘祐, 安達 聡介, 関根 正幸, 加勢 宏明, 八幡 哲郎, 田中 憲一

    日本産科婦人科学会雑誌   63 ( 2 )   443 - 443   2011年2月

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  • E-cadherin遺伝子多型と子宮内膜症の発症リスクとの関連

    吉田 邦彦, 吉原 弘祐, 安達 聡介, 生野 寿史, 加嶋 克則, 藤田 和之, 八幡 哲郎, 増崎 英明, 片渕 秀隆, 伊熊 健一郎, 杉並 洋, 田中 憲一

    日本産科婦人科学会雑誌   63 ( 2 )   906 - 906   2011年2月

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  • 子宮内膜症の全ゲノム関連解析による疾患感受性SNPの探索

    安達 聡介, 吉原 弘祐, 生野 寿史, 八幡 哲郎, 伊熊 健一郎, 杉並 洋, 片渕 秀隆, 増崎 英明, 田中 憲一

    日本産科婦人科学会雑誌   63 ( 2 )   904 - 904   2011年2月

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  • 子宮体癌症例におけるレプチンおよびレプチン受容体の組織内発現に関する検討

    芦澤 直浩, 安達 聡介, 吉原 弘祐, 八幡 哲郎, 田中 憲一

    日本産科婦人科学会雑誌   62 ( 2 )   527 - 527   2010年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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  • 子宮内胎児発育遅延の病態解明を目的とした胎盤血管での発現遺伝子群の解析

    吉原 弘祐, 山口 雅幸, 安達 聡介, 田中 憲一

    日本産科婦人科学会雑誌   61 ( 2 )   648 - 648   2009年2月

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    記述言語:日本語   出版者・発行元:(公社)日本産科婦人科学会  

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