Updated on 2024/05/03

写真a

 
UEKI Satoshi
 
Organization
University Medical and Dental Hospital Ophthalmology Lecturer
Title
Lecturer
External link

Degree

  • 博士(医学) ( 2005.3   新潟大学 )

Research Areas

  • Life Science / Ophthalmology

Research History

  • Niigata University   Ophthalmology, University Medical and Dental Hospital   Lecturer

    2023.5

  • Niigata University   Ophthalmology, University Medical and Dental Hospital   Assistant Professor

    2022.4 - 2023.4

  • Niigata University   Ophthalmology, University Medical and Dental Hospital   Specially Appointed Assistant Professor

    2021.4 - 2022.3

  • Niigata University   Brain Research Institute Center for Integrated Human Brain Science   Assistant Professor

    2016.4 - 2021.3

  • Niigata University   Institute for Research Promotion Center for Transdisciplinary Research   Assistant Professor

    2011.4 - 2016.3

 

Papers

  • Hyperopic anisometropia with a shorter axial length ipsilateral to the ptotic eye in children with congenital ptosis. International journal

    Satoshi Ueki, Yuji Suzuki, Megumi Kiyokawa, Takako Hanyu, Takeo Fukuchi

    BMC ophthalmology   21 ( 1 )   358 - 358   2021.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: To investigate the clinical characteristics of children with congenital ptosis, with particular attention given to the incidence of anisometropia, and the difference in axial length (AL) between the right and left eyes. METHODS: The medical charts of 55 patients with congenital ptosis at Niigata University Medical and Dental Hospital were retrospectively analyzed. Clinical characteristics, including age, cycloplegic refraction, AL, and the presence of amblyopia and its causes were analyzed. RESULTS: Age at the initial visit was 16 ± 20 (mean ± standard deviation, the same applies below) months. Of the 49 patients whose cycloplegic refraction was measured, hyperopic anisometropia, defined as ≥ one-diopter difference in spherical equivalent (SE), was observed in 1/11, 9/27 and 5/11 patients with bilateral, right, and left ptosis, respectively. Among 14/38 patients with hyperopic anisometropia involving unilateral ptosis, 13 demonstrated a larger SE in the ptotic eye than in the non-ptotic eye. The inter-eye difference in AL (AL of the ptotic eye minus that of the non-ptotic eye) in six patients with unilateral ptosis and hyperopic anisometropia ipsilateral to the ptotic eye (-0.29 ± 0.40 mm) was significantly smaller than that in three patients with unilateral ptosis and no hyperopic anisometropia (0.38 ± 0.29 mm). CONCLUSIONS: At our institute, children with congenital ptosis had a high incidence of hyperopic anisometropia ipsilateral to the ptotic eye. Furthermore, this condition was associated with a shorter axial length. These results indicate that refractive correction for hyperopic anisometropia is important for proper visual development in children with congenital ptosis.

    DOI： 10.1186/s12886-021-02126-8

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  • Visual outcome of aquaporin-4 antibody-positive optic neuritis with maintenance therapy.

    Satoshi Ueki, Tetsuhisa Hatase, Megumi Kiyokawa, Izumi Kawachi, Etsuji Saji, Osamu Onodera, Takeo Fukuchi, Hironaka Igarashi

    Japanese journal of ophthalmology   65 ( 5 )   699 - 703   2021.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE: To assess the effect of maintenance therapy on visual outcomes in preventing recurrences one year after first onset in patients with aquaporin-4 antibody (AQP4Ab)-positive optic neuritis. STUDY DESIGN: Retrospective study. METHODS: The medical charts of 56 patients with optic neuritis (22 with AQP4Ab-positive and 34 with AQP4Ab-negative) at Niigata University Medical and Dental Hospital were retrospectively analyzed. Clinical characteristics, including visual acuity and number of recurrences one year after first onset, were compared among patients who were AQP4Ab-positivie with and those without maintenance therapy such as oral prednisolone and azathioprine, as well as those who were AQP4Ab-negative. RESULTS: The mean ages were 49.3 and 45.2 years in the AQP4Ab-positive and the AQP4Ab-negative groups. The female to male ratio was 21:1 and 18:16 in the two groups, respectively. Multiple between-group comparison showed a statistically significant difference in visual acuity one year after first onset between the AQP4Ab-positive without maintenance therapy group and the AQP4Ab-negative group (0.05 (median, same applies below) vs. 1.0, p < 0.01). There was also a statistically significant difference in the number of recurrences in the year after first onset between the AQP4Ab-positive with and without maintenance therapy groups (1 vs. 0, p < 0.01). CONCLUSION: This study demonstrates that patients with AQP4Ab-positive optic neuritis without maintenance therapy had the poorest visual acuity and the most recurrences one year after first onset. These results indicate that reducing the number of recurrences with maintenance therapy could improve the visual outcomes in patients with AQP4Ab-positive optic neuritis.

    DOI： 10.1007/s10384-021-00858-0

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  • Retinal Aquaporin-4 and Regulation of Water Inflow Into the Vitreous Body. International journal

    Satoshi Ueki, Yuji Suzuki, Hironaka Igarashi

    Investigative ophthalmology & visual science   62 ( 2 )   24 - 24   2021.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    Purpose: Details of the posterior eye water dynamics are unclear. Aquaporin-4 (AQP4), a water channel, plays an important role in water dynamics in the central nervous system and is also present in the ocular tissue. The purpose of this study was to reveal the role of AQP4 in the water dynamics of the posterior eye using in vivo JJ vicinal coupling proton exchange (JJVCPE) magnetic resonance imaging (MRI) of AQP4 knockout (KO) mice and their wild-type littermates (controls). Methods: JJVCPE MRI of the eye was performed on five AQP4 KO mice and seven control mice. We assessed the normalized signal intensities of a region of interest (ROI) set in the vitreous body after H217O administration. The results of the two groups were compared using a two-tailed Mann-Whitney U test. Results: A statistical analysis revealed that the normalized ROI signal intensities at the steady state were significantly lower (P = 0.010, <0.05) in the AQP4 KO mice (mean ± SD, 84.5% ± 2.7%) than the controls (mean ± SD, 88.8% ± 1.9%). Conclusions: The present study using JJVCPE MRI of the eye demonstrated that retinal AQP4 has a potential role in the regulation of water inflow into the vitreous body. Absence of AQP4 in the KO mice probably induces lower water outflow from the vitreous body. Our results could help clarify the pathogenesis of various ocular diseases.

    DOI： 10.1167/iovs.62.2.24

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  • Age-Dependent Changes in Regulation of Water Inflow Into the Vitreous Body. International journal

    Satoshi Ueki, Yuji Suzuki, Yukimi Nakamura, Hironaka Igarashi

    Investigative ophthalmology & visual science   64 ( 12 )   22 - 22   2023.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE: Water inflow into the vitreous body regulated by retinal aquaporin-4 distributed within Müller cells has been observed in mice; however, the changes in this phenomenon with age remain unknown. This study aimed to evaluate whether intravenously injected H2O also flows into the vitreous body of human subjects and to investigate whether water dynamics in the human posterior eye change with age using [15O]H2O positron emission tomography (PET). METHODS: Forty-six normal adult volunteers underwent [15O]H2O PET, and the standard uptake value (SUV) in the center of the vitreous body after 1000-MBq [15O]H2O administration was assessed. The SUV was fitted to an exponential curve, and y0, the steady state of the SUV, and b, the speed of increase in the SUV, were calculated. The results for patients ranging from in age from 20 to 39, 40 to 59, and 60 to 79 years were compared using analyses of variance followed by Games to Howell tests. RESULTS: For the parameter y0, statistical analysis revealed no statistically significant differences among the three groups. For parameter b, statistical analysis revealed statistically significant differences between the 20 to 39 and 60 to 79 age groups (P = 0.000), the 40 to 59 and 60 to 79 age groups (P = 0.025), and the 20 to 39 and 40 to 59 age groups (P = 0.037). CONCLUSIONS: The present study revealed that H2O injected into the vein flows into the human vitreous body and that the speed of increase in water flow into the vitreous body decreases with aging. This study suggests that water dynamics in the posterior eye, or the retinal glymphatic pathway, change significantly with aging.

    DOI： 10.1167/iovs.64.12.22

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  • Spasm of Near Reflex in a Patient with Autism Spectrum Disorder: A Case Report

    Satoshi Ueki, Yukari Hasegawa, Tetsuhisa Hatase, Takako Hanyu, Jun Egawa, Atsushi Miki, Takeo Fukuchi

    Reports   6 ( 3 )   38 - 38   2023.8

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    Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    Spasm of near reflex (SNR) involves intermittent spasm of one or more of the three near reflex components. Psychiatric disorders are one cause of SNR. We describe a patient with SNR diagnosed with autism spectrum disorder (ASD). A 36-year-old male with esotropia since childhood was referred due to headache and dizziness. The alternate prism cover test showed 30 prism diopters at both near and distant fixation. Four months after his first visit, he was diagnosed with ASD. Twenty-nine months after his first visit, he underwent strabismus surgery to treat concomitant esotropia. Postoperatively, the angle of strabismus improved but remained variable. Because the angle of strabismus varied, we suspected SNR; the diagnosis was performed after evaluating the patient’s microfluctuations in accommodation with Speedy-K. However, it was difficult to distinguish convergence spasm from concomitant esotropia in this patient because he has had a history of esotropia since childhood. In a patient with concomitant esotropia, if the symptoms are not exclusively due to strabismus, SNR should be suspected. Although the relationship between SNR and the pathology of ASD is unknown, it is possible that patients with ASD are more likely to develop SNR.

    DOI： 10.3390/reports6030038

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  • Posterior microphthalmos with achievement of good visual acuity and disappearance of papillomacular retinal folds: a case report

    Takako Hanyu, Satoshi Ueki, Yukari Hasegawa, Megumi Kiyokawa, Takeo Fukuchi

    BMC Ophthalmology   22 ( 1 )   2022.11

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Background

    Posterior microphthalmos (PM) is a rare condition with poor visual prognosis even after amblyopia treatment. We report a case of PM with achievement of good visual acuity and disappearance of papillomacular retinal folds (PFs) over a period of 7 years.

    Case presentation

    A girl aged 3 years and 5 months was referred to our hospital, after poor visual acuity was identified at a medical checkup for 3-year-olds. She had severe spherical hyperopia: + 17.25 D in the right eye (RE) and + 18 D in the left eye (LE). Her corrected visual acuity was 20/200 in the RE and 20/250 in the LE. PFs were observed in both eyes on optical coherence tomography (OCT), and the diagnosis of PM was made based on the normal corneal diameter and anterior chamber depth. During the course of the disease, a gradual decrease in the height of the PFs was observed on OCT. The corrected visual acuity at age 10 years was 20/20 in the RE and 20/25 in the LE.

    Conclusions

    The visual prognosis of PM is poor, and only one case with good visual acuity has been reported in the literature. The patient in the present case not only developed good visual acuity, but also showed improvement in macular morphology, which was not noted in previous reports. Early diagnosis of PM and early amblyopia treatment is important for the visual development in PM.

    DOI： 10.1186/s12886-022-02648-9

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    Other Link： https://link.springer.com/article/10.1186/s12886-022-02648-9/fulltext.html

  • One-year recurrence rate of Graves ophthalmopathy presenting as diplopia in the primary position after varied doses of intravenous methylprednisolone followed by oral prednisolone with dosing based on the magnetic resonance imaging findings

    Satoshi Ueki, Yukari Hasegawa, Tetsuhisa Hatase, Megumi Kiyokawa, Takeo Fukuchi

    Japanese Journal of Ophthalmology   67 ( 1 )   91 - 96   2022.10

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1007/s10384-022-00954-9

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    Other Link： https://link.springer.com/article/10.1007/s10384-022-00954-9/fulltext.html

  • The Prevalence of Brain Abnormalities in Japanese Patients with Optic Nerve Hypoplasia. International journal

    Megumi Kiyokawa, Satoshi Ueki, Tetsuhisa Hatase, Takako Hanyu, Takeo Fukuchi

    Neuro-ophthalmology (Aeolus Press)   45 ( 4 )   265 - 270   2021

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    Language：English  

    The purpose of this study was to investigate the clinical characteristics of Japanese patients with optic nerve hypoplasia (ONH), with particular attention to the prevalence of brain abnormalities. We retrospectively analysed the medical charts of 16 patients who were diagnosed with ONH and who underwent magnetic resonance imaging (MRI) at Niigata University Medical and Dental Hospital. We recorded the age, sex, laterality, initial eye and visual symptoms, best-corrected visual acuity, and brain abnormalities on MRI (excluding ONH). The median age at the first visit to the Ophthalmology Clinic was 2.4 years old. Four patients were male and 12 were female. ONH was bilateral in 11 patients and unilateral in five. Best-corrected visual acuity ranged from no light perception to 20/20. Seven patients (43.8%) had brain abnormalities including agenesis of the septum pellucidum, pituitary gland hypofunction, cerebral dysplasia, and West syndrome. Five of these seven patients had general manifestations since the neonatal or infantile period. Our study revealed the prevalence of brain abnormalities associated with optic nerve hypoplasia in Japanese patients at a single institute. Because two of 11 patients had no general manifestations since the neonatal or infantile period but demonstrated brain abnormalities, MRI should be performed to investigate all patients with ONH.

    DOI： 10.1080/01658107.2020.1844758

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  • Longitudinal GluCEST MRI Changes and Cerebral Blood Flow in 5xFAD Mice

    Hironaka Igarashi, Satoshi Ueki, Hiroki Kitaura, Tae Kera, Ken Ohno, Masaki Ohkubo, Mika Terumitsu-Tsujita, Akiyoshi Kakita, Ingrid L Kwee

    Contrast Media & Molecular Imaging   2020   1 - 12   2020.11

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    Publishing type：Research paper (scientific journal)   Publisher：Hindawi Limited  

    Many of the focal neurological symptoms associated with Alzheimer’s disease (AD) are due to synaptic loss. Glutamate chemical exchange saturation transfer (GluCEST) magnetic resonance imaging (MRI) is a candidate method to assess synaptic dysfunction. We assessed chronological changes in GluCEST in a 5xFAD mouse model of AD, comparing Glucest effects and regional cerebral blood flow (CBF). GluCEST effects and CBF in 5xFAD mice aged 1–15 months and their littermates (WT) were measured. Neurite orientation dispersion and density imaging (NODDI) MRI reflecting dendritic/axonal density was also measured and compared with GluCEST in 7-month-old mice. While regional CBF’s decrease began at 7 months, GluCEST-reduction effects preceded hypoperfusion of the temporal cortex and hippocampus. While longitudinal 5xFAD mouse measurements revealed a correlation between the regional GluCEST effects and CBF, a generalized linear mixed model revealed statistically different correlations in cortical and basal brain regions. Further, NODDI-derived neurite density correlated with GluCEST effects in the parietal cortex, but not in the hippocampus, thereby revealing regional differences in pathophysiological mechanisms. Finally, GluCEST’s effects correlated with regional synaptophysin. These results demonstrate that GluCEST can reflect subtle synaptic changes and may be a potential imaging method for AD diagnosis as well as serve as a biomarker of AD progression.

    DOI： 10.1155/2020/8831936

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    Other Link： http://downloads.hindawi.com/journals/cmmi/2020/8831936.xml

  • Participant-driven Simulation Protocol With a Mock Scanner for Pediatric Magnetic Resonance Neuroimaging Preparation Without Sedation Reviewed

    Kenichi Yamada, Yuji Suzuki, Satoshi Ueki, Kosuke Itoh, Masaki Watanabe, Kiyotaka Suzuki, Hironaka Igarashi

    Clinical Simulation in Nursing   47   40 - 47   2020.10

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.ecns.2020.07.002

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  • 正常眼圧緑内障の経過中に視交叉部腫瘍合併が明らかになった4例

    長谷川 友加里, 坂上 悠太, 植木 智志, 飯川 龍, 中野 里絵子, 末武 亜紀, 栂野 哲哉, 福地 健郎

    日本眼科学会雑誌   123 ( 12 )   1101 - 1108   2019.12

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    Language：Japanese   Publisher：(公財)日本眼科学会  

    目的:正常眼圧緑内障の加療中に視交叉部腫瘍の合併が明らかになった4例を提示し,腫瘍合併を疑うべき所見について検討する.症例:合併した視交叉部腫瘍は,3例は下垂体腺腫,1例は鞍結節部髄膜腫であった.いずれの症例も急速な視野障害進行と片眼もしくは両眼の視力低下を伴っていた.2例では乳頭蒼白を伴っていたが,2例ではなかった.症例1の両耳側半盲所見は,10°内視野測定で初めて検出された.結論:緑内障症例に視交叉部腫瘍合併を疑う眼科的所見として,垂直経線を境界とする視野障害,急激な視力低下・視野悪化,乳頭蒼白などが挙げられるが,進行した緑内障症例では耳側半盲所見が判別しづらいことがあり,10°内視野測定が有用な場合がある.疑われる場合には積極的に頭蓋内画像検索を行うことが勧められる.(著者抄録)

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  • グルタミン酸CEST-MRイメージング法の開発とアルツハイマー病モデルマウスへの応用 Reviewed

    大野 健, 植木 智志, 大久保 真樹, 鈴木 清隆, 五十嵐 博中, 中田 力

    脳循環代謝   31 ( 1 )   99 - 99   2019.11

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    Language：Japanese   Publisher：(一社)日本脳循環代謝学会  

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  • Visualizing the Distribution of Matrix Metalloproteinases in Ischemic Brain Using In Vivo 19F-Magnetic Resonance Spectroscopic Imaging. Reviewed International journal

    Vincent J Huber, Hironaka Igarashi, Satoshi Ueki, Mika Terumitsu-Tsujita, Chikako Nito, Ken Ohno, Yuji Suzuki, Kosuke Itoh, Ingrid L Kwee, Tsutomu Nakada

    Contrast media & molecular imaging   2019   8908943 - 8908943   2019

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    Matrix metalloproteinases (MMPs) damage the neurovascular unit, promote the blood-brain barrier (BBB) disruption following ischemic stroke, and play essential roles in hemorrhagic transformation (HT), which is one of the most severe side effects of thrombolytic therapy. However, no biomarkers have presently been identified that can be used to track changes in the distribution of MMPs in the brain. Here, we developed a new 19F-molecular ligand, TGF-019, for visualizing the distribution of MMPs in vivo using 19F-magnetic resonance spectroscopic imaging (19F-MRSI). We demonstrated TGF-019 has sufficient sensitivity for the specific MMPs suspected in evoking HT during ischemic stroke, i.e., MMP2, MMP9, and MMP3. We then utilized it to assess those MMPs at 22 to 24 hours after experimental focal cerebral ischemia on MMP2-null mice, as well as wild-type mice with and without the systemic administration of the recombinant tissue plasminogen activator (rt-PA). The 19F-MRSI of TGN-019-administered mice showed high signal intensity within ischemic lesions that correlated with total MMP2 and MMP9 activity, which was confirmed by zymographic analysis of ischemic tissues. Based on the results of this study, 19F-MRSI following TGN-019 administration can be used to assess potential therapeutic strategies for ischemic stroke.

    DOI： 10.1155/2019/8908943

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  • Aquaporin-4 facilitator TGN-073 promotes interstitial fluid circulation within the blood-brain barrier: [17O]H2O JJVCPE MRI study. International journal

    Vincent J Huber, Hironaka Igarashi, Satoshi Ueki, Ingrid L Kwee, Tsutomu Nakada

    Neuroreport   29 ( 9 )   697 - 703   2018.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    The blood-brain barrier (BBB), which imposes significant water permeability restriction, effectively isolates the brain from the systemic circulation. Seemingly paradoxical, the abundance of aquaporin-4 (AQP-4) on the inside of the BBB strongly indicates the presence of unique water dynamics essential for brain function. On the basis of the highly specific localization of AQP-4, namely, astrocyte end feet at the glia limitans externa and pericapillary Virchow-Robin space, we hypothesized that the AQP-4 system serves as an interstitial fluid circulator, moving interstitial fluid from the glia limitans externa to pericapillary Virchow-Robin space to ensure proper glymphatic flow draining into the cerebrospinal fluid. The hypothesis was tested directly using the AQP-4 facilitator TGN-073 developed in our laboratory, and [O]H2O JJ vicinal coupling proton exchange MRI, a method capable of tracing water molecules delivered into the blood circulation. The results unambiguously showed that facilitation of AQP-4 by TGN-073 increased turnover of interstitial fluid through the system, resulting in a significant reduction in [O]H2O contents of cortex with normal flux into the cerebrospinal fluid. The study further suggested that in addition to providing the necessary water for proper glymphatic flow, the AQP-4 system produces a water gradient within the interstitial space promoting circulation of interstitial fluid within the BBB.

    DOI： 10.1097/WNR.0000000000000990

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  • 視線解析装置を用いた網膜色素変性患者の読書評価

    村田 憲章, 宮本 ふう子, 木下 直彦, 植木 智志, 畑瀬 哲尚, 福地 健郎

    日本視能訓練士協会誌   46   245 - 256   2017.12

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：(公社)日本視能訓練士協会  

    【目的】網膜色素変性(RP)患者の黙読能力の他覚的評価を試みた。【対象及び方法】新潟大学医歯学総合病院通院中のRP患者11名(37.4±17.6歳)と健常者(N)20名(46.9±17.2歳)。視線解析装置(Tobii Tx300)にて横書き文黙読時の平均停留時間およびsaccade時間、100文字あたりの読み時間、停留回数を算出した。また読書時のsaccadeを幅と角度の2変数から混合ガウスモデルによるクラスタ分類およびクラス分類し、その割合をχ2検定で検討した。【結果】平均停留時間はRP群256.3±41.6msec、N群215.7±24.9msec(p<0.01)、saccade時間RP群44.28±8.26msec、N群50.78±11.45msec(P=0.11)、停留回数はRP群31.1±7.9回、N群32.7±10.6回(p=0.66)、読み時間はRP群9.4±3.0sec、N群8.8±3.4sec(p=0.65)で、RP群において停留時間が延長した。各saccadeは短・長順行、逆行、行替えに分類されその構成に両群間で有意差を認めた(p=0.03)。RP群において短順行、長順行saccadeが多く、逆行saccadeが少なかった(p<0.01)。【結論】RP群は平均停留時間が延長しsaccadeパターンに変化がみられたが、読み時間は延長しなかった。今後は視野異常の重症度に着目した解析が必要である。(著者抄録)

    DOI： 10.4263/jorthoptic.046F128

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    Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J01962&link_issn=&doc_id=20180306160031&doc_link_id=130006515549&url=http%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F130006515549&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

  • Maturational decrease of glutamate in the human cerebral cortex from childhood to young adulthood: a 1H-MR spectroscopy study. Reviewed International journal

    Mami Shimizu, Yuji Suzuki, Kenichi Yamada, Satoshi Ueki, Masaki Watanabe, Hironaka Igarashi, Tsutomu Nakada

    Pediatric research   82 ( 5 )   749 - 752   2017.11

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    BackgroundThe aim of the present study was to investigate maturational changes in glutamate (Glu) in the human cerebral cortex from childhood to young adulthood using 3.0-Tesla proton magnetic resonance spectroscopy (1H-MRS), which is capable of quantifying Glu in vivo.MethodsNormal volunteers comprising 11 children (aged 4-13 years) and 11 young adults (aged 18-33 years) participated in the study. Single-voxel point-resolved spectroscopy (PRESS, repetition time/echo time=2,000/80 ms) was performed on the frontal and occipital cortices, and the Glu-to-creatine ratio (Glu/Cr) and N-acetylaspartate-to-creatine ratio (NAA/Cr) were determined.ResultsIn both the frontal and occipital cortices, Glu/Cr was significantly lower during young adulthood relative to that during childhood. NAA/Cr did not differ significantly between the two age groups.ConclusionThis study has provided objective evidence that cerebral cortical Glu/Cr decreases between childhood and young adulthood. The observed decrease in Glu/Cr may reflect the simultaneous occurrence of maturational changes, such as changes in cortical microstructure and the intercellular compartmentation of Glu metabolism.

    DOI： 10.1038/pr.2017.101

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  • Clinicopathological features in anterior visual pathway in neuromyelitis optica Reviewed

    Mariko Hokari, Akiko Yokoseki, Musashi Arakawa, Etsuji Saji, Kaori Yanagawa, Fumihiro Yanagimura, Yasuko Toyoshima, Kouichirou Okamoto, Satoshi Ueki, Tetsuhisa Hatase, Riuko Ohashi, Takeo Fukuchi, Kohei Akazawa, Mitsunori Yamada, Akiyoshi Kakita, Hitoshi Takahashi, Masatoyo Nishizawa, Izumi Kawachi

    ANNALS OF NEUROLOGY   79 ( 4 )   605 - 624   2016.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-BLACKWELL  

    ObjectiveNeuromyelitis optica spectrum disorder (NMOsd) is an autoimmune disorder of the central nervous system characterized by aquaporin-4 (AQP4) autoantibodies. The aim of this study was to elucidate the characteristics of involvement of the anterior visual pathway (AVP) and neurodegeneration via glia-neuron interaction in NMOsd.
    MethodsThirty Japanese patients with serologically verified NMOsd were assessed with a neuro-ophthalmological study. Using 27 tissue blocks from 13 other cases of NMOsd, we performed neuropathological analysis of glial and neuroaxonal involvement in the AVP.
    ResultsThe AVP involvement in NMOsd was characterized by the following, compared to multiple sclerosis: (1) longitudinally extensive optic neuritis (ON); (2) more severe visual impairment and worse prognosis for ON; (3) unique AQP4 dynamics, including loss of AQP4 immunoreactivity on astrocytes with complement activation in ON lesions, loss of AQP4 immunoreactivity on Muller cells with no deposition of complement in the retinas, and densely packed AQP4 immunoreactivity on astrocytes in gliosis of secondary anterograde/retrograde degeneration in the optic nerves and retinal nerve fiber layer (RNFL); and (4) more severe neurodegeneration, including axonal accumulation of degenerative mitochondria and transient receptor potential melastatin 4 channel with complement-dependent astrocyte pathology in ON lesions, mild loss of horizontal cells, and RNFL thinning and loss of ganglion cells with abundance of AQP4(+) astrocytes, indicating secondary retrograde degeneration after ON.
    InterpretationSevere and widespread neuroaxonal damage and unique dynamics of astrocytes/Muller cells with alterations of AQP4 were prominent in the AVP and may be associated with poor visual function and prognosis in NMOsd. Ann Neurol 2016;79:605-624

    DOI： 10.1002/ana.24608

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  • 抗アクアポリン4抗体陽性視神経炎診療ガイドライン

    三村 治, 不二門 尚, 植木 智志, 毛塚 剛司, 敷島 敬悟, 菅澤 淳, 中馬 秀樹, 中尾 雄三, 中村 誠, 山上 明子, 抗アクアポリン4抗体陽性視神経炎診療ガイドライン作成委員会

    神経眼科   31 ( 4 )   509 - 525   2014.12

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  • Secondary Glaucoma Associated With Bilateral Complete Ring Cysts of the Ciliary Body Reviewed

    Masaaki Seki, Takeo Fukuchi, Takaiko Yoshino, Jun Ueda, Hiruma Hasebe, Satoshi Ueki, Tokuhide Oyama, Atsushi Fukushima, Haruki Abe

    JOURNAL OF GLAUCOMA   23 ( 7 )   477 - 481   2014.9

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    Purpose: To report a case of acute glaucoma due to complete ring cyst of the ciliary body.
    Patients and Methods: A 33-year-old woman experienced blurred vision in her left eye. Intraocular pressure of the left eye was elevated accompanied with a very shallow anterior chamber. Anterior segment-optical coherence tomography and ultrasound biomicroscopy detected ring-shaped ciliary masses in the both eyes. Myopic change and contact between the ciliary mass and lens in the left eye suggested the presence of aqueous misdirection resulting in forward displacement of the lens-iris diaphragm. Because elevated intraocular pressure was refractory to conservative management, the left eye underwent clear lens aspiration and implantation of intraocular lens.
    Results: Although the anterior chamber became deep in the left eye initially after lens extraction in conjunction with core vitrectomy, possible aqueous misdirection recurred. Second vitrectomy in the left eye together with posterior and anterior capsulotomies, to establish humoral communication between the anterior and posterior chambers, deepened the anterior chamber and lowered the intraocular pressure. The anterior chamber in the fellow right eye remained deep a year after the episode.
    Conclusions: This is the first reported case of bilateral ring cysts of the ciliary body. The manifestation caused secondary glaucoma, which was resolved by lensectomy and vitrectomy.

    DOI： 10.1097/IJG.0b013e31827a088c

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  • 眼科健診から専門医を受診した小児の検討

    石井 雅子, 医療技術学部, 落合 竣, 松浦 将人, 畑瀬 哲尚, 植木 智志, 羽入 貴子, 福地 健郎

    眼科臨床紀要   7 ( 2 )   131 - 135   2014.2

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  • 高度の視野障害が見られたoptic disc drusenの1例

    上田 潤, 大湊 絢, 植木 智志, 栂野 哲哉, 坂上 悠太, 五十嵐 遼子, 福地 健郎, 田沢 博

    眼科臨床紀要   6 ( 12 )   987 - 987   2013.12

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  • Intravitreal injection of methotrexate was effective in a case of optic disc invasion of systemic malignant lymphoma Reviewed

    66 ( 3 )   355 - 360   2012.3

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    DOI： 10.11477/mf.1410104132

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    Other Link： http://search.jamas.or.jp/link/ui/2012151248

  • Three children of pontine glioma with esotropia as the initial manifestation Reviewed

    66 ( 1 )   49 - 56   2012.1

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    DOI： 10.11477/mf.1410104061

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    Other Link： http://search.jamas.or.jp/link/ui/2012092785

  • 前立腺癌による眼窩および脈絡膜転移を併発し診断が困難であった1例 Reviewed

    植木 智志, 高木 峰夫, 村上 健治, 尾山 徳秀, 阿部 春樹

    神経眼科   28 ( 3 )   320 - 325   2011.9

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  • Evaluation of the Optic Nerve Complex in the Orbit Using Coronal Fast Magnetic Resonance Imaging Reviewed

    Tetsuhisa Hatase, Mineo Takagi, Kouichirou Okamoto, Shoichi Inagawa, Atsuhiko Iijima, Satoshi Ueki, Haruki Abe

    NEURO-OPHTHALMOLOGY   34 ( 2 )   88 - 95   2010.4

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    Recently available coronal fast magnetic resonance imaging (MRI) has very high spatial resolution with good contrast between the optic nerves and cerebrospinal fluid (CSF). The aim of this study was to evaluate the diagnostic value of coronal fast imaging in optic nerve diseases. Thirty-five patients with various Neuro-ophthalmic conditions including 9 with optic neuritis, 6 with optic atrophy, 5 with glaucoma, 4 with segmental optic nerve hypoplasia and 11 with other optic neuropathies including orbital apex syndrome were evaluated with the three-dimensional fast imaging employing steady-state acquisition (FIESTA) sequence in addition to standard MRI protocols. The optic nerve complexes were evaluated on coronal images of the orbits. Detailed demonstration of the optic nerve complex-the optic nerve, the perineural CSF space and dural sheath-could be readily obtained with FIESTA sequence. The acute phase of both optic neuritis and perineuritis showed enlargement of the perineural CSF space; the optic nerve was swollen in optic neuritis but not in perineuritis. Cases of optic atrophy and glaucoma showed perineural CSF space enlargement with normal optic sheath circumference and a thinner optic nerve, while optic nerve hypoplasia showed a smaller dural sheath circumference without perineural CSF space enlargement. In the cases of orbital apex syndrome optic nerve compression by the extraocular muscles was clearly shown. Coronal FIESTA imaging of the orbit is capable of delineating detailed structural changes in the optic nerve complex and is of diagnostic value for the differentiation of optic nerve diseases.

    DOI： 10.3109/01658101003587825

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  • Retinal nerve fiber layer thickness in recovered and persistent amblyopia Reviewed

    Atsushi Miki, Motohiro Shirakashi, Kiyoshi Yaoeda, Yu Kabasawa, Satoshi Ueki, Mineo Takagi, Haruki Abe

    Clinical Ophthalmology   4 ( 1 )   1061 - 1064   2010

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    Purpose: To investigate, using optical coherence tomography (OCT), whether retinal nerve fiber layer thickness (RNFLT) is affected in amblyopic eyes. Methods: Using OCT (Stratus OCTTM [Carl Zeiss, Dublin, CA]), the RNFLT was measured in 26 patients with persistent unilateral amblyopia and in 25 patients with recovered unilateral amblyopia. The RNFLT was compared between the affected and fellow eyes in patients with persistent amblyopia and in those with recovered amblyopia, and between the amblyopic eyes of patients with persistent amblyopia and the previously amblyopic eyes of patients with recovered amblyopia. Results: In patients with persistent amblyopia and in those with recovered amblyopia, the affected eyes were significantly more hyperopic than the fellow eyes. The average (±standard deviation) RNFLT measured 105.5 ± 14.0 μm for the persistently amblyopic eyes
    this value did not significantly differ from that of the fellow eyes (105.2 ± 13.0 μm) or the previously amblyopic eyes of recovered amblyopia (107.1 ± 11.7 μm). Also, logistic regression analysis adjusting for refraction showed no significant difference in the RNFLT between the persistently amblyopic eyes and the previously amblyopic eyes. Conclusions: Our results indicate that there is no significant change in the RNFLT in amblyopic eyes. © 2010 Miki et al.

    DOI： 10.2147/OPTH.S13145

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  • Optic disc measurements using the Heidelberg Retina Tomograph in amblyopia Reviewed

    Atsushi Miki, Motohiro Shirakashi, Kiyoshi Yaoeda, Yu Kabasawa, Satoshi Ueki, Mineo Takagi, Haruki Abe

    Clinical Ophthalmology   4 ( 1 )   1025 - 1028   2010

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    Purpose: To investigate the characteristics of optic disc parameters in amblyopic eyes in which retinal involvement is uncertain. Methods: A total of 44 patients with a history of unilateral amblyopia (27 patients with persistent amblyopia and 17 patients with resolved amblyopia) were examined using the Heidelberg Retina Tomograph (HRT) II. Parameters examined included disc area, cup area, cup volume, rim area, rim volume, cup-to-disc area ratio, and mean retinal nerve fiber layer thickness. Results: In patients with persistent amblyopia, the amblyopic eyes were significantly more hyperopic than the fellow eyes. In the HRT parameters, there were no significant differences between the amblyopic and fellow eyes. In addition, after adjusting for refraction, the presence of strabismus, and the disc area, there was no significant difference in any HRT parameter between the amblyopic eyes of patients with persistent amblyopia and the previously amblyopic eyes of patients with resolved amblyopia. Conclusions: We did not find any strong evidence for the deformity of the optic disc of amblyopic eyes. © 2010 Miki et al.

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  • Preoperative depiction of cavernous sinus invasion by pituitary macroadenoma using three-dimensional anisotropy contrast periodically rotated overlapping parallel lines with enhanced reconstruction imaging on a 3-tesla system Reviewed

    Yuichiro Yoneoka, Naoto Watanabe, Hitoshi Matsuzawa, Itaru Tsumanuma, Satoshi Ueki, Tsutomu Nakada, Yukihiko Fujii

    JOURNAL OF NEUROSURGERY   108 ( 1 )   37 - 41   2008.1

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    Object. Three-dimensional anisotropy contrast (CDAC) magnetic resonance (MR) imaging provides clear depiction of neuronal fibers. The aim of this study was to identify intracavernous cranial nerves in patients with pituitary macro-adenoma and in healthy volunteers by using 3DAC MR imaging on a 3-tesla system and to preoperatively predict cavernous sinus invasion by pituitary macroadenoma.
    Methods. Thirty-three patients (cavernous sinuses in 66 sides) with pituitary macroadenomas and 25 healthy volunteers (50 sides) participated in this study. Coronal 3DAC MR images constructed from diffusion weighted images, acquired with periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) sequences, and T2-weighted reverse images were obtained at the same anatomical locations using a 3-tesla MR imaging system. Attempts were made to identify the cranial nerves.
    Results. The oculomotor and ophthalmic/maxillary nerves were preoperatively identified in all sides (66 sides in patients and 50 sides in healthy volunteers) on 3DAC MR images. In the 33 patients, cavernous sinus invasion was revealed in 10 (12 [18.2%] of 66 sides) by intraoperative endoscopic observation. Coronal 3DAC MR images revealed that the oculomotor nerves were half surrounded with adenoma in all 12 of these sides, and the ophthalmic/maxillary nerves were half encapsulated with tumor (sensitivity/specificity: 100%/100% and 83%/100%, respectively).
    Conclusions. Preoperative evaluation of pituitary macroadenomas using 3DAC PROPELLER MR imaging on a 3-tesla system is likely to be a powerful noninvasive method of detecting cavernous sinus invasion, which can potentially dominate the therapeutic strategy for these lesions.

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  • Assessment of axonal degeneration along the human visual pathway using diffusion trace analysis Reviewed

    Satoshi Ueki, Yukihiko Fujii, Hitoshi Matsuzawa, Mineo Takagi, Haruki Abe, Ingrid L. Kwee, Tsutomu Nakada

    AMERICAN JOURNAL OF OPHTHALMOLOGY   142 ( 4 )   591 - 596   2006.10

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    center dot PURPOSE: The effectiveness of diffusion trace value analysis for non-invasive assessment of retinal ganglion cell (RGC) axonal degeneration at multiple anatomic levels along the human visual pathway under clinical setting was evaluated.
    center dot DESIGN: Imaging study.
    center dot METHODS: Ten patients with unilateral chronic optic neuropathy of varying cause and 16 age-matched normal subjects were studied. Trace, a tensor invariant that is considered to be a sensitive index for pathologic changes in axons, was analyzed at nine anatomic sites in each subject, namely, bilaterally at the level of the optic nerves, uncrossed chiasmal fibers, optic tracts and optic radiations, and crossed chiasmal fibers, using a 3.0 Tesla magnetic resonance imaging system.
    center dot RESULTS: Trace values of the optic nerve and un- crossed chiasmal fibers ipsilateral to the affected eye, the crossed chiasmal fibers, and optic tracts bilaterally were significantly higher than those of the corresponding anatomic sites in normal subjects. The optic nerve and uncrossed chiasmal fibers ipsilateral to the unaffected side and optic radiations, bilaterally, had trace values which were not significantly different from the values of the corresponding anatomic levels in normal subjects. The increase in trace value in the optic nerve and uncrossed chiasmal fibers ipsilateral to the affected side was greater than those of the crossed chiasmal fibers and optic tracts.
    center dot CONCLUSIONS: Findings are highly consistent with a degenerative process of RGC axons and trace values are quantitatively well correlated to predicted pathology at the given anatomical sites. Trace value measurement at multiple sites along fiber pathways appears to be a powerful addition to clinical assessment of the functionality of components of the visual pathways during various stages of a pathologic process. (Am J Ophthalmol 2006; 142:591-596. (c) 2006 by Elsevier Inc. All rights reserved.)

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  • 中心暗点をきたした両側後頭側頭葉障害による相貌失認の1例 Reviewed

    三木 淳司, 大学院医歯学総合研究科眼科, 高木 峰夫, 谷本 直之, 植木 智志, 臼井 知聡, 長谷川 茂, 阿部 春樹

    臨床眼科   60 ( 6 )   1083 - 1086   2006.6

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    DOI： 10.11477/mf.1410101685

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    Other Link： http://search.jamas.or.jp/link/ui/2006314914

  • 糖尿病乳頭症と前部虚血性視神経症 Reviewed

    小川涼太, 高木峰夫, 佐野友紀, 植木智志, 三木淳司, 臼井知聡, 長谷川茂, 阿部春樹

    神経眼科   23 ( 1 )   63 - 70   2006.3

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    DOI： 10.20566/18810624_23(1)_63

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  • 甲状腺眼症急性期の治療 Reviewed

    高木峰夫, 松田英伸, 植木智志, 三木淳司, 臼井知聡, 長谷川茂, 阿部春樹

    神経眼科   23 ( 2 )   238-247 - 247   2006

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  • [Multifocal visually evoked responses in two children with optic neuritis] Reviewed

    Hatase T, Hasegawa S, Tanimoto N, Miki A, Ueki S, Usui T, Takaki M, Abe H

    Nihon Ganka Gakkai Zasshi   109 ( 8 )   497 - 503   2005.8

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  • Multifocal Visually Evoked Responses in Two Children with Optic Neuritis Reviewed

    HATASE Tetsuhisa, HASEGAWA Shigeru, TANIMOTO Naoyuki, MIKI Atsushi, UEKI Satoshi, USUI Tomoaki, TAKAKI Mineo, ABE Haruki

    Journal of Japanese Ophthalmological Society   109 ( 8 )   497 - 503   2005.8

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  • Quantitative Assessment of Axonal Function in the Human Optic nerve using Diffusion-weighted Magnetic Resonance Imaging on a High-field System

    UEKI Satoshi

    Niigata medical journal   119 ( 8 )   474 - 480   2005.8

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    Other Link： http://hdl.handle.net/10191/3485

  • Night blindness with depolarizing pattern of ON/OFF response in electroretinogram: A case report Reviewed

    T Usui, N Tanimoto, S Ueki, A Miki, M Takagi, S Hasegawa, H Abe

    DOCUMENTA OPHTHALMOLOGICA   111 ( 1 )   15 - 21   2005.7

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    Purpose: To present a patient who has night blindness with a depolarizing pattern of ON/OFF response by electroretinography (ERG). Case: A 43-year-old woman had had night blindness and poorly corrected visual acuity since childhood. Parental consanguinity was noted. The patient had suffered from mental retardation, epilepsy, and mild cerebellar ataxia. Corrected visual acuity was 20/30 in the right eye and 20/25 in the left. Goldmann perimetry showed no scotoma but slight depression with internal isoptors. No evidence for rod activity was observed by Goldmann-Weekers adaptometry. The ocular fundi appeared normal. Methods: Conventional full-field ERGs to scotopic (dim and bright flash) and photopic (bright flash and flicker) stimuli were recorded. Photopic ERG responses to long flash stimulation (200 ms) were also examined. Results: The scotopic responses to dim flash were non-recordable, while those to bright flash were severely reduced. The photopic responses to bright flash were decreased. The amplitudes of flicker responses also were significantly decreased, and the implicit times of those responses were prolonged. Although the amplitudes of a- and d-waves to long flash stimulation were reduced, those of the b-wave were within normal range. The implicit times of a-, b- and d-waves were significantly prolonged. The patient showed a normal rise for the photopic b-wave but lacked a normal failing slope after the b-wave peak. An OFF-response late-negativity was also noted. Conclusions: The abnormal ON/OFF response found in the patient could be diagnosed as depolarizing pattern, characterized by elevation of the plateau to a positive potential above the prestimulus baseline. Since the ERG waveforms and clinical features found in our patient were different from those in previous reports, her ERG findings might reflect another retinal physiological mechanism.

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  • Ocular fundus images by scanning laser ophthalmoscopy in a patient with enhanced S-cone syndrome Reviewed

    T Usui, M Ichibe, N Tanimoto, S Ueki, M Takagi, S Hasegawa, H Abe, Y Miyagawa, M Nakazawa

    RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES   24 ( 6 )   946 - 952   2004.12

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    Purpose: To present ocular fundus images in a patient with enhanced S-cone syndrome by scanning laser ophthalmoscopy. A 34-year-old Japanese woman whose parents were consanguineous showed mismatched electroretinographic responses to photopically balanced single-flash stimuli, with a larger signal to blue light than to red light. The central macula lacked a foveal reflex, and the surface was dull. Yellowish flecks and retinal pigment epithelium atrophy were evident in a ring at and around the vascular arcades. Faint black pigmentation was deposited in the mid peripheral retina.
    Methods: The ocular fundus of the patient was observed by scanning laser ophthalmoscopy with the use of an argon blue laser (wavelength, 488 nm), a helium-neon laser (633 nm), and an infrared laser (780 nm).
    Results: The argon blue laser showed numerous black spots of pigment, which were observed as faint pigmentation by conventional ophthalmoscopy. The spots were more enhanced with the argon blue laser than with the helium-neon laser. The white spots, which corresponded to the yellowish flecks in a ring at and around the vascular arcades, were more enhanced with the helium-neon laser than with the argon blue or infrared laser. Hypopigmentation of the retinal pigment epithelium was best shown with the infrared laser.
    Conclusion: An abnormality of the retinal structure in enhanced S-cone syndrome may exist in the inner and outer retinal levels, in at least some patients.

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  • [A case of acute angle-closure glaucoma secondary to annular ciliochoroidal detachment after unsutured cataract surgery] Reviewed

    Ueki S, Fukuchi T, Funaki S, Wakai M, Sawada H, Suda K, Tanaka Y, Nakatsue T, Ohta A, Hara H, Shirakashi M, Abe H

    Nihon Ganka Gakkai Zasshi   108 ( 4 )   219 - 225   2004.4

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  • A Case of Acute Angle-closure Glaucoma Secondary to Annular Ciliochoroidal Detachment after Unsutured Cataract Surgery Reviewed

    UEKI Satoshi, FUKUCHI Takeo, FUNAKI Shigeo, WAKAI Mikiko, SAWADA Hideko, SUDA Kieko, TANAKA Yoko, NAKATSUE Tomoko, OHTA Akiko, HARA Hiroaki, SHIRAKASHI Motohiro, ABE Haruki

    108 ( 4 )   219 - 225   2004.4

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  • ERG rod a-wave in Oguchi disease Reviewed

    T Usui, N Tanimoto, S Ueki, M Takagi, S Hasegawa, H Abe, K Sekiya, M Nakazawa

    VISION RESEARCH   44 ( 5 )   535 - 540   2004.3

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    We analyzed the change in the ERG rod a-wave waveform during the course of dark adaptation in two patients with Oguchi disease. Two Japanese patients showed a homozygous arrestin 1147delA mutation. Scotopic flash ERGs were recorded after different periods of dark adaptation. ERG rod a-waves were obtained after subtraction of the cone ERG contribution. The rod a-waves were fitted with a model of the rod receptor signal. The parameters, Rm(p3) (maximum a-wave amplitude) and S (sensitivity) were calculated. Longer periods in the dark produced larger rod a-wave but only to the first flash presented. The amplitude of the response to subsequent flashes was essentially independent of the period of dark adaptation. Rm(p3) increased with advance of dark adaptation. However, S was nearly constant. Our results suggest that the cause of delayed dark adaptation is not to be sought in the activation of phototransduction process or the regeneration of rhodopsin per se but rather in the deactivation process of the phototransduction cascade. (C) 2003 Elsevier Ltd. All rights reserved.

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  • Mizuo phenomenon observed by scanning laser ophthalmoscopy in a patient with Oguchi disease Reviewed

    T Usui, M Ichibe, S Ueki, M Takagi, S Hasegawa, H Abe, K Sekiya, M Nakazawa

    AMERICAN JOURNAL OF OPHTHALMOLOGY   130 ( 3 )   359 - 361   2000.9

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    PURPOSE: To elucidate the origin of the abnormal fundus reflex in Oguchi disease,
    METHODS: The ocular fundus of a 63-year-old woman who showed a homozygous arrestin 1147delA mutation was observed by scanning laser ophthalmoscopy with the use of an argon blue laser (wavelength, 488 nm), a helium neon laser (633 nm), and an infrared laser (780 nm).
    RESULTS: Diffuse, fine, white particles, which do not exist in normal subjects, were clearly demonstrated only with the helium-neon laser. After 4-hour dark adaptation, the abnormal particles disappeared, but then they reappeared gradually during 30 minutes of light adaptation, in accordance with the golden metallic reflex.
    CONCLUSION: The white particles found by helium-neon laser could be the origin of the abnormal fundus reflex in Oguchi disease. (C) 2000 by Elsevier Science Inc. All rights reserved.

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  • 眼圧上昇を伴った甲状腺眼症 Reviewed

    高木峰夫, 植木智志, 長谷川茂, 臼井知聡, 長谷部日, 三木淳司, 高田律子, 早川祐貴, 阿部春樹

    神経眼科   16 ( 3 )   331-336 - 336   1999

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  • 視神経乳頭部の先天異常. 仁科幸子(編): 専門医のための眼科診療クオリファイ9 子どもの眼と疾患.

    植木智志（ Role： Sole author）

    文光堂  2011 

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  • 抗アクアポリン4抗体陽性視神経炎. 中馬秀樹(編): 専門医のための眼科診療クオリファイ7 視神経疾患のすべて.

    高木峰夫, 植木智志（ Role： Joint author）

    文光堂  2011 

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Research Projects

  • 緑内障による構造と機能の変化はどのように患者のQOLを障害するのか？

    Grant number：22K09764

    2022.4 - 2025.3

    System name：科学研究費助成事業

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    福地 健郎, 赤木 忠道, 坂上 悠太, 五十嵐 遼子, 植木 智志, 奥田 修二郎

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    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

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  • 活動時機能画像のエントロピー解析を用いた発達性読み書き障害の脳活動の解明研究

    Grant number：20K20514

    2020.7 - 2025.3

    System name：科学研究費助成事業

    Research category：挑戦的研究(開拓)

    Awarding organization：日本学術振興会

    鈴木 雄治, 酒多 穂波, 小枝 達也, 渡辺 将樹, 植木 智志

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    Grant amount：\25740000 （ Direct Cost: \19800000 、 Indirect Cost：\5940000 ）

    発達性読み書き障害（Dyslexia）は、主に音韻処理に関する特異的な発達障害を呈し、約
    ２％弱の学童が困難な状況にあると報告されている。適切な早期治療介入の機会が増し一定の効果が見込めるようになったが、読字における脳活動の異常メカニズムは解明されていない為、より高次な学習である漢字の読字や書字に対する効果的な介入は困難な状況のまま残されている。
    本研究では、超高磁場MRI装置のもつ特性を最大限に利用した脳機能画像のエントロピー解析に着目し、安静時及び読書時における脳活動の解析方法の開発研究を進める。fMRIデータにはミクロな機能連結の状態を反映する情報が含まれており、信号時系列のエントロピー解析によってランダムネス（複雑さの度合い）を評価できる。7.0T-fMRIの高空間分解能及び高信号雑音比を最大限に活かした撮像方法を用いることにより、個々の到達レベルに合わせた「読み」といった複雑な活動時の脳機能の詳細な評価を可能にするものと考えている。
    我々が提唱する情報理論的観点からのエントロピー解析は、脳活動をダイナミックに捉え
    てDyslexia特有の脳活動の異常メカニズムの評価を行う試みで、これは世界で類のない独創性・新規性があり、そこから得られる研究結果はDyslexia 児のみならず学校教育をはじめとした社会全体に大きな影響をもたらすことが期待できる挑戦的な研究である。新たなる非侵襲的な解析方法の開発は、様々な医療介入に伴う異常活動部位やパターンの変化の検出に繋がり、Dyslexiaの客観的な診断方法の開発や効果判定のツールとなることが期待できる。これは、問題を抱える児童に適切な環境・医療介入を与えることに貢献し、さらなる社会的状況の困難さの回避を可能とする。

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  • Role of aqauaporin-4 in the aqueous humor dynamics

    Grant number：18K09441

    2018.4 - 2021.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (C)

    Awarding organization：Japan Society for the Promotion of Science

    Ueki Satoshi

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

    The purpose of this study was to clarify the role of aquaporin-4 in post-iridial flow, the pathway of aqueous humor through the vitreous to the retina. We performed JJ vicinal coupling proton exchange magnetic resonance imaging (JJVCPE MRI), a technique to observe the signal changes induced by H2(17)O injected through the femoral vein in aquaporin -4 knockout and control mice. The signal changes in the vitreous body were significantly greater in the aquaporin-4 knockout mice group than in the control mice group. This result suggests that H2(17)O injected into the femoral vein of mice becomes as a part of aqueous humor and flows into the vitreous body, and that the inflow of water from the vitreous into the retina via aquaporin-4 in Muller cells of the retina probably be diminished in aquaporin-4 knockout mice. The inflow of water into the retina via aquaporin-4 suggested in this study indicates that the system called glymphatic flow in the brain may also exist in the retina.

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Teaching Experience

  • 臨床実習IA

    2015
    Institution name：新潟大学

  • 臨床実習IB

    2015
    Institution name：新潟大学

  • 臨床実習Ⅰ

    2012
    -
    2017
    Institution name：新潟大学

  • 視覚器

    2012
    -
    2017
    Institution name：新潟大学