Faculty Profiles - UEKI Satoshi

Intravitreal injection of methotrexate was effective in a case of optic disc invasion of systemic malignant lymphoma Reviewed

眼科健診から専門医を受診した小児の検討

石井雅子, 医療技術学部, 落合竣, 松浦将人, 畑瀬哲尚, 植木智志, 羽入貴子, 福地健郎

眼科臨床紀要 7 ( 2 ) 131 - 135 2014.2

Background of children consulted ophthalmologist from visual screening in health check program

Masako Ishii, Shun Ochiai, Masato Matsuura, Tetsuhisa Hatase, Satoshi Ueki, Takako Hanyu, Takeo Fukuchi

Folia Japonica de Ophthalmologica Clinica 7 ( 2 ) 131 - 135 2014.2

高度の視野障害が見られたoptic disc drusenの1例

上田潤, 大湊絢, 植木智志, 栂野哲哉, 坂上悠太, 五十嵐遼子, 福地健郎, 田沢博

眼科臨床紀要 6 ( 12 ) 987 - 987 2013.12

66 ( 3 ) 355 - 360 2012.3

Three children of pontine glioma with esotropia as the initial manifestation Reviewed

66 ( 1 ) 49 - 56 2012.1

前立腺癌による眼窩および脈絡膜転移を併発し診断が困難であった1例 Reviewed

植木智志, 高木峰夫, 村上健治, 尾山徳秀, 阿部春樹

神経眼科 28 ( 3 ) 320 - 325 2011.9

A case of orbital and choroidal metastases from prostate cancer

Satoshi Ueki, Mineo Takagi, Kenji Murakami, Tokuhide Oyama, Haruki Abe

Neuro-Ophthalmology Japan 28 ( 3 ) 320 - 325 2011

Language：Japanese Publishing type：Research paper (scientific journal)

A 68-year-old man who had received hormone therapy for prostate cancer was referred to our hospital with complaints of left visual loss. An ophthalmoscopic examination revealed, a yellowish-white, subretinal elevation in his left eye. One week later, a left exophthalmos appeared, and computed tomography and magnetic resonance imaging were conducted. The images revealed tumors in the left orbit and left middle cranial fossa. The left optic nerve was deviated by the left orbital tumor, but not directly compressed. With his past history of multiple bone metastases from prostate cancer and a finding by computed tomography of osteoblastic changes of the left anterior clinoid process of the sphenoid bone, we regarded the tumors as metastases from prostate cancer. We also regarded the subretinal elevation as a choroidal metastasis from prostate cancer. The signal intensity of the metastatic tumor was reduced in T2-weighted magnetic resonance images after radiation therapy. Although orbital and choroidal metastases from prostate cancer are rare, clinicians should not overlook these.

Evaluation of the Optic Nerve Complex in the Orbit Using Coronal Fast Magnetic Resonance Imaging Reviewed

Tetsuhisa Hatase, Mineo Takagi, Kouichirou Okamoto, Shoichi Inagawa, Atsuhiko Iijima, Satoshi Ueki, Haruki Abe

NEURO-OPHTHALMOLOGY 34 ( 2 ) 88 - 95 2010.4

Language：English Publishing type：Research paper (scientific journal) Publisher：INFORMA HEALTHCARE

Recently available coronal fast magnetic resonance imaging (MRI) has very high spatial resolution with good contrast between the optic nerves and cerebrospinal fluid (CSF). The aim of this study was to evaluate the diagnostic value of coronal fast imaging in optic nerve diseases. Thirty-five patients with various Neuro-ophthalmic conditions including 9 with optic neuritis, 6 with optic atrophy, 5 with glaucoma, 4 with segmental optic nerve hypoplasia and 11 with other optic neuropathies including orbital apex syndrome were evaluated with the three-dimensional fast imaging employing steady-state acquisition (FIESTA) sequence in addition to standard MRI protocols. The optic nerve complexes were evaluated on coronal images of the orbits. Detailed demonstration of the optic nerve complex-the optic nerve, the perineural CSF space and dural sheath-could be readily obtained with FIESTA sequence. The acute phase of both optic neuritis and perineuritis showed enlargement of the perineural CSF space; the optic nerve was swollen in optic neuritis but not in perineuritis. Cases of optic atrophy and glaucoma showed perineural CSF space enlargement with normal optic sheath circumference and a thinner optic nerve, while optic nerve hypoplasia showed a smaller dural sheath circumference without perineural CSF space enlargement. In the cases of orbital apex syndrome optic nerve compression by the extraocular muscles was clearly shown. Coronal FIESTA imaging of the orbit is capable of delineating detailed structural changes in the optic nerve complex and is of diagnostic value for the differentiation of optic nerve diseases.

DOI： 10.3109/01658101003587825

Retinal nerve fiber layer thickness in recovered and persistent amblyopia Reviewed

Atsushi Miki, Motohiro Shirakashi, Kiyoshi Yaoeda, Yu Kabasawa, Satoshi Ueki, Mineo Takagi, Haruki Abe

Clinical Ophthalmology 4 ( 1 ) 1061 - 1064 2010

Language：English Publishing type：Research paper (scientific journal)

Purpose: To investigate, using optical coherence tomography (OCT), whether retinal nerve fiber layer thickness (RNFLT) is affected in amblyopic eyes. Methods: Using OCT (Stratus OCTTM [Carl Zeiss, Dublin, CA]), the RNFLT was measured in 26 patients with persistent unilateral amblyopia and in 25 patients with recovered unilateral amblyopia. The RNFLT was compared between the affected and fellow eyes in patients with persistent amblyopia and in those with recovered amblyopia, and between the amblyopic eyes of patients with persistent amblyopia and the previously amblyopic eyes of patients with recovered amblyopia. Results: In patients with persistent amblyopia and in those with recovered amblyopia, the affected eyes were significantly more hyperopic than the fellow eyes. The average (±standard deviation) RNFLT measured 105.5 ± 14.0 μm for the persistently amblyopic eyes
this value did not significantly differ from that of the fellow eyes (105.2 ± 13.0 μm) or the previously amblyopic eyes of recovered amblyopia (107.1 ± 11.7 μm). Also, logistic regression analysis adjusting for refraction showed no significant difference in the RNFLT between the persistently amblyopic eyes and the previously amblyopic eyes. Conclusions: Our results indicate that there is no significant change in the RNFLT in amblyopic eyes. © 2010 Miki et al.

DOI： 10.2147/OPTH.S13145

Optic disc measurements using the Heidelberg Retina Tomograph in amblyopia Reviewed

Atsushi Miki, Motohiro Shirakashi, Kiyoshi Yaoeda, Yu Kabasawa, Satoshi Ueki, Mineo Takagi, Haruki Abe

Clinical Ophthalmology 4 ( 1 ) 1025 - 1028 2010

Language：English Publishing type：Research paper (scientific journal)

Purpose: To investigate the characteristics of optic disc parameters in amblyopic eyes in which retinal involvement is uncertain. Methods: A total of 44 patients with a history of unilateral amblyopia (27 patients with persistent amblyopia and 17 patients with resolved amblyopia) were examined using the Heidelberg Retina Tomograph (HRT) II. Parameters examined included disc area, cup area, cup volume, rim area, rim volume, cup-to-disc area ratio, and mean retinal nerve fiber layer thickness. Results: In patients with persistent amblyopia, the amblyopic eyes were significantly more hyperopic than the fellow eyes. In the HRT parameters, there were no significant differences between the amblyopic and fellow eyes. In addition, after adjusting for refraction, the presence of strabismus, and the disc area, there was no significant difference in any HRT parameter between the amblyopic eyes of patients with persistent amblyopia and the previously amblyopic eyes of patients with resolved amblyopia. Conclusions: We did not find any strong evidence for the deformity of the optic disc of amblyopic eyes. © 2010 Miki et al.

DOI： 10.2147/OPTH.S13143

Preoperative depiction of cavernous sinus invasion by pituitary macroadenoma using three-dimensional anisotropy contrast periodically rotated overlapping parallel lines with enhanced reconstruction imaging on a 3-tesla system Reviewed

Yuichiro Yoneoka, Naoto Watanabe, Hitoshi Matsuzawa, Itaru Tsumanuma, Satoshi Ueki, Tsutomu Nakada, Yukihiko Fujii

JOURNAL OF NEUROSURGERY 108 ( 1 ) 37 - 41 2008.1

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER ASSOC NEUROLOGICAL SURGEONS

Object. Three-dimensional anisotropy contrast (CDAC) magnetic resonance (MR) imaging provides clear depiction of neuronal fibers. The aim of this study was to identify intracavernous cranial nerves in patients with pituitary macro-adenoma and in healthy volunteers by using 3DAC MR imaging on a 3-tesla system and to preoperatively predict cavernous sinus invasion by pituitary macroadenoma.
Methods. Thirty-three patients (cavernous sinuses in 66 sides) with pituitary macroadenomas and 25 healthy volunteers (50 sides) participated in this study. Coronal 3DAC MR images constructed from diffusion weighted images, acquired with periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) sequences, and T2-weighted reverse images were obtained at the same anatomical locations using a 3-tesla MR imaging system. Attempts were made to identify the cranial nerves.
Results. The oculomotor and ophthalmic/maxillary nerves were preoperatively identified in all sides (66 sides in patients and 50 sides in healthy volunteers) on 3DAC MR images. In the 33 patients, cavernous sinus invasion was revealed in 10 (12 [18.2%] of 66 sides) by intraoperative endoscopic observation. Coronal 3DAC MR images revealed that the oculomotor nerves were half surrounded with adenoma in all 12 of these sides, and the ophthalmic/maxillary nerves were half encapsulated with tumor (sensitivity/specificity: 100%/100% and 83%/100%, respectively).
Conclusions. Preoperative evaluation of pituitary macroadenomas using 3DAC PROPELLER MR imaging on a 3-tesla system is likely to be a powerful noninvasive method of detecting cavernous sinus invasion, which can potentially dominate the therapeutic strategy for these lesions.

DOI： 10.3171/JNS/2008/108/01/0037

Unusual strabismus fixus

Mineo Takagi, Tetsuhisa Hatase, Satoshi Ueki, Atsuhiko Iijima, Ritsuko Takada, Atsushi Miki, Haruki Abe

Neuro-Ophthalmology Japan 24 ( 3 ) 267 - 273 2007

Language：Japanese Publishing type：Research paper (scientific journal)

A 66-year-old Japanese man had bilateral extraocular muscle swelling, followed by an obvious change in his bilateral eye position along with motility limitation over a one-year period. His right eye with high myopia and poor vision showed extreme eye deviation three times, which mimicked 'strabismus fixus' towards the upper temporal, down and lower nasal directions, although the extraocular muscle swelling was milder than that observed in his left eye. Usually cases of strabismus fixus with high myopia are irreversible and associated with an extraocular muscle path shift along with posterior eyeball prolapse from the muscle cone. However in this case, in the eye with high myopia, there was a rotation to an extreme eye position that occurred without any shift or prolapse, and which was reversible. Therefore, it is hypothesized that extreme ocular rotation due to an extraocular muscle disorder can easily occur in eyes with high myopia.

Assessment of axonal degeneration along the human visual pathway using diffusion trace analysis Reviewed

Satoshi Ueki, Yukihiko Fujii, Hitoshi Matsuzawa, Mineo Takagi, Haruki Abe, Ingrid L. Kwee, Tsutomu Nakada

AMERICAN JOURNAL OF OPHTHALMOLOGY 142 ( 4 ) 591 - 596 2006.10

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

center dot PURPOSE: The effectiveness of diffusion trace value analysis for non-invasive assessment of retinal ganglion cell (RGC) axonal degeneration at multiple anatomic levels along the human visual pathway under clinical setting was evaluated.
center dot DESIGN: Imaging study.
center dot METHODS: Ten patients with unilateral chronic optic neuropathy of varying cause and 16 age-matched normal subjects were studied. Trace, a tensor invariant that is considered to be a sensitive index for pathologic changes in axons, was analyzed at nine anatomic sites in each subject, namely, bilaterally at the level of the optic nerves, uncrossed chiasmal fibers, optic tracts and optic radiations, and crossed chiasmal fibers, using a 3.0 Tesla magnetic resonance imaging system.
center dot RESULTS: Trace values of the optic nerve and un- crossed chiasmal fibers ipsilateral to the affected eye, the crossed chiasmal fibers, and optic tracts bilaterally were significantly higher than those of the corresponding anatomic sites in normal subjects. The optic nerve and uncrossed chiasmal fibers ipsilateral to the unaffected side and optic radiations, bilaterally, had trace values which were not significantly different from the values of the corresponding anatomic levels in normal subjects. The increase in trace value in the optic nerve and uncrossed chiasmal fibers ipsilateral to the affected side was greater than those of the crossed chiasmal fibers and optic tracts.
center dot CONCLUSIONS: Findings are highly consistent with a degenerative process of RGC axons and trace values are quantitatively well correlated to predicted pathology at the given anatomical sites. Trace value measurement at multiple sites along fiber pathways appears to be a powerful addition to clinical assessment of the functionality of components of the visual pathways during various stages of a pathologic process. (Am J Ophthalmol 2006; 142:591-596. (c) 2006 by Elsevier Inc. All rights reserved.)

DOI： 10.1016/j.ajo.2006.05.042

中心暗点をきたした両側後頭側頭葉障害による相貌失認の1例 Reviewed

三木淳司, 大学院医歯学総合研究科眼科, 高木峰夫, 谷本直之, 植木智志, 臼井知聡, 長谷川茂, 阿部春樹

臨床眼科 60 ( 6 ) 1083 - 1086 2006.6

糖尿病乳頭症と前部虚血性視神経症 Reviewed

小川涼太, 高木峰夫, 佐野友紀, 植木智志, 三木淳司, 臼井知聡, 長谷川茂, 阿部春樹

神経眼科 23 ( 1 ) 63 - 70 2006.3

甲状腺眼症急性期の治療 Reviewed

高木峰夫, 松田英伸, 植木智志, 三木淳司, 臼井知聡, 長谷川茂, 阿部春樹

神経眼科 23 ( 2 ) 238-247 - 247 2006

A case with diabetic papillopathy and anterior ischemic optic neuropathy

Ryota Ogawa, Mineo Takagi, Tomonori Sano, Satoshi Ueki, Atsushi Miki, Tomoaki Usui, Shigeru Hasegawa, Haruki Abe

Neuro-Ophthalmology Japan 23 ( 1 ) 63 - 70 2006

Language：Japanese Publishing type：Research paper (scientific journal)

We report a case of simultaneous onset of diabetic papillopathy and anterior ischemic optic neuropathy. A 60-year-old female noticed decreased left visual acuity and upon examination was found to exhibit optic disc swelling in both eyes. There was hyperemic optic disc swelling with only an enlarged blind spot in her right eye, while the left eye showed pallid swelling with a relatively lower visual field defect. Fluorescein angiography showed filling defect in the upper portion of the left disc. Because of the bilateral onset, we treated her with steroid semi-pulse therapy. After the treatment she exhibited high blood sugar and HbAIc, and subsequently, we diagnosed her as having diabetic papillopathy (DP) in the right eye and anterior ischemic optic neuropathy (AION) in the left eye. After six months, her right eye was also found to have AION. This suggests that the pathogenesis of DP and AION are similar and that DP is a mild type of AION.