Updated on 2025/06/30

写真a

 
YAMAMOTO Suguru
 
Organization
Academic Assembly Institute of Medicine and Dentistry IGAKU KEIRETU Professor
Graduate School of Medical and Dental Sciences Center of Nephrology Professor
Title
Professor
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Degree

  • 新潟大学大学院医歯学総合研究科生体機能調節医学 ( 2004.3   新潟大学 )

Research Interests

  • CKD-MBD

  • indoxyl sulfate

  • Uremic toxins

  • Hemodialysis

  • Chronic kidney disease

  • アミロイドーシス

Research Areas

  • Life Science / Nephrology

Research History (researchmap)

  • 新潟大学医歯学総合病院   血液浄化療法部   病院教授

    2022.6

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  • Niigata University   Medical and Dental Hospital, Blood Purification Center   Associate Professor

    2016.7 - 2022.5

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  • Niigata University   Graduate School of Medical and Dental Sciences   Assistant Professor

    2015.5 - 2016.6

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  • Niigata University   Graduate School of Medical and Dental Sciences   Specially Appointed Assistant Professor

    2011.5 - 2015.4

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  • バンダービルト大学   小児科   リサーチフェロー

    2008.5 - 2011.3

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  • Fukui Medical University

    2001.7 - 2003.6

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  • Niigata University   Medical and Dental Hospital, Internal Medicine II

    2000.4 - 2001.6

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  • Niigata University   Medical and Dental Hospital

    1998.5 - 2000.3

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Research History

  • Niigata University   Institute of Medicine and Dentistry, Academic Assembly   Professor

    2025.1

  • Niigata University   Center of Nephrology, Graduate School of Medical and Dental Sciences   Professor

    2025.1

  • Niigata University   University Medical and Dental Hospital Blood Purification Center   Associate Professor

    2016.7 - 2024.12

  • Niigata University   University Medical and Dental Hospital Nephrology and Rheumatology   Assistant Professor

    2015.5 - 2016.6

  • Niigata University   Graduate School of Medical and Dental Sciences   Specially Appointed Assistant Professor

    2011.5 - 2015.4

Education

  • Niigata University   Graduate School of Medical and Dental Sciences   内部環境医学講座

    2001.4 - 2004.3

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  • Niigata University   School of Medicine   医学科

    1992.4 - 1998.3

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Professional Memberships

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Committee Memberships

  • 日本アミロイドーシス学会   理事  

    2022.10   

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    Committee type：Academic society

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  • 日本透析医学会   慢性腎臓病に伴う骨・ミネラル代謝異常の診療ガイドライン改訂ワーキンググループ  

    2022.8   

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  • J-DOPPS   CKD-MBD working group  

    2021.8   

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  • 日本透析医学会   危機管理委員会  

    2021.8   

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  • 日本透析医学会   統計調査委員会  

    2021.8   

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  • 日本透析医学会   専門医制度委員会  

    2021.8   

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  • 日本透析医学会   編集委員会  

    2021.8 - 2024.7   

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  • 日本腎臓学会   評議員  

    2020.6   

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  • 日本透析医学会   評議員  

    2020.4   

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  • 日本透析医学会   会員  

       

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    Committee type：Academic society

    日本透析医学会

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  • 日本腎臓学会   会員  

       

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    Committee type：Academic society

    日本腎臓学会

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  • 日本内科学会   会員  

       

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    日本内科学会

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Papers

  • Appropriate Anthropometric Indices for Geriatric Nutritional Risk Index in Predicting Mortality in Older Japanese Patients: A Comparison of the Lorentz Formula and Body Mass Index. Reviewed

    Kou Kitabayashi, Suguru Yamamoto, Ichiei Narita

    The Tohoku journal of experimental medicine   2024.1

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1620/tjem.2024.J001

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  • Alkaline Phosphatase and Parathyroid Hormone Levels: International Variation and Associations With Clinical Outcomes in the DOPPS Reviewed

    Suguru Yamamoto

    Kidney International Reports   2024.1

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/J.EKIR.2024.01.002

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  • Pruritus and protein-bound uremic toxins in patients undergoing hemodialysis: a cross-sectional study. International journal

    Suguru Yamamoto, Takahiro Tanaka, Kentaro Omori, Isei Ei, Kaori Kikuchi, Ayano Konagai, Shin Goto, Nobutaka Kitamura, Ichiei Narita

    Clinical kidney journal   17 ( 1 )   sfae007   2024.1

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Patients undergoing hemodialysis frequently experience pruritus; its severity is associated with poor quality of life and mortality. Recent progress in hemodialysis treatment has improved the removal of small- and middle-molecular-weight molecules; however, the removal of protein-bound uremic toxins (PBUTs) remains difficult. It is possible that pruritus is associated with serum PBUTs in patients undergoing hemodialysis. METHODS: We conducted a multicenter cross-sectional study in patients undergoing hemodialysis (n = 135). The severity of pruritus was assessed using the 5D-itch scale and medication use. Serum PBUTs, including indoxyl sulfate, p-cresyl sulfate, indole acetic acid, phenyl sulfate, and hippuric acid, were measured using mass spectrometry; the PBUT score was calculated from these toxins using principal component analysis. Univariate and multiple regression analyses were performed to examine independent predictors of pruritus. RESULTS: Pruritus was reported by 62.2%, 21.5%, and 13.3%, 1.5% and 0.7% as 5 (not at all), 6-10, 11-15, 16-20, and 21-25 points, respectively. The PBUT score was higher in patients undergoing dialysis having pruritus than those without pruritus (0.201 [-0.021 to 0.424] vs -0.120 [-0.326 to 0.087]; P = 0.046). The PBUT score was shown to have an association with the presence of pruritus (coefficient 0.498[Formula: see text]0.225, odds ratio: 1.65 [1.06-2.56]; P = 0.027). CONCLUSION: Uremic pruritus was frequently found and associated with the PBUT score in patients undergoing hemodialysis. Further studies are required to clarify the impact of PBUTs on uremic pruritus and to explore therapeutic strategies in patients undergoing hemodialysis.

    DOI： 10.1093/ckj/sfae007

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  • Removal of α1-Microglobulin Using Post-Dilution Online Hemodiafiltration with Polymethylmethacrylate Membrane: An Open-Label, Single-Arm Study. Reviewed International journal

    Shiori Yoshida, Suguru Yamamoto, Daisuke Miyauchi, Ryohei Terashima, Atsushi Hashimoto, Haruna Miyazawa, Takahiro Tanaka, Masahiro Ishizawa, Mototsugu Tanaka, Yoshihiko Tomita, Ikuo Aoike, Shin Goto, Ichiei Narita

    Blood purification   1 - 7   2023.11

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    INTRODUCTION: The removal of low- and medium-molecular-weight proteins has been improved with online hemodiafiltration (OL-HDF) and hemodialysis using high-flux membranes; however, the outcomes of patients with end-stage kidney disease (ESKD) undergoing dialysis treatment are still worse than in the general population. α1-Microglobulin (α1-m), with a molecular weight of 33,000 Da, may contribute to dialysis-related disorders and mortality. However, the removal is insufficient even with current OL-HDF using the polysulfone (PS) membrane, which is common in Japan. Polymethylmethacrylate (PMMA) membranes can remove medium- to high-molecular-weight proteins by adsorption. This study aimed to assess the efficacy of removing medium- to high-molecular-weight proteins, such as α1-m and β2-microglobulin (β2-m), through post-dilution OL-HDF with PMMA (Post-PMMA). The assessment was conducted in comparison to pre-dilution OL-HDF with PS (Pre-PS), using an open-label, single-arm study. METHODS: Seven patients with ESKD on Pre-PS underwent Post-PMMA with replacement volume of 30 mL/min (low flow) and 50 mL/min (high flow). Clearance and removal rates of α1-m, β2-m, small molecules, inflammatory cytokines, and albumin were measured at 60 and 240 min of treatment. RESULTS: Clearance rates of α1-m at 60 min were -2.8 ± 5.2 mL/min with Pre-PS, -0.4 ± 2.6 mL/min with Post-PMMA (low), and 0.6 ± 3.4 mL/min with Post-PMMA (high). The removal rate of α1-m was higher in Post-PMMA than that in Pre-HDF-PS (Post-PMMA [high] 17.7 ± 5.9%, Post-PMMA [low] 15.0 ± 5.6%, and Pre-PS 4.1 ± 5.5%). Adsorption clearance of β2-m was increased with Post-PMMA. Albumin leakage in Post-PMMA was not higher than that in Pre-PS. CONCLUSION: The removal rate of α1-m with Post-PMMA was higher than that with Pre-PS. The PMMA membrane adsorbed β2-m, suggesting the removal effect of medium- to high-molecular-weight proteins by the adsorption method. Since Post-PMMA effectively removes α1-m without excessive albumin leakage, it will be useful for patients with ESKD, especially those with a poor nutritional status.

    DOI： 10.1159/000534459

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  • Low muscle strength and physical function contribute to falls in hemodialysis patients, but not muscle mass Reviewed

    Shirai N, Yamamoto S, Osawa Y, Tsubaki A, Morishita S, Sugahara T, Narita I

    Clin Exp Nephrol   in press   2023

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    INTRODUCTION: Patients on hemodialysis (HD) have a higher incidence of fractures than the general population. Sarcopenia is frequently observed in patients on HD; however, the association of falls with sarcopenia and its diagnostic factors, including muscle mass, muscle strength, and physical function, are incompletely understood. METHODS: This prospective cohort study was conducted at a single center. Sarcopenia was assessed according to the 2019 Asian Working Group for Sarcopenia diagnostic criteria. Muscle mass was measured the bioelectrical impedance method. Grip strength was evaluated to assess muscle strength, while the Short Physical Performance Battery (SPPB) was used to assess physical function. Falls and their detailed information were surveyed every other week. RESULTS: This study analyzed 65 HD patients (median age, 74.5 [67.5-80.0] years; 33 women [49.2%]). Sarcopenia was diagnosed in 36 (55.4%) patients. During the 1-year observation period, 31 (47.7%) patients experienced accidental falls. The falls group had lower median grip strength than the non-falls group (14.7 [11.4-21.8] kg vs. 22.2 [17.9-27.6] kg; p < 0.001). The median SPPB score was also lower in the falls versus non-falls group (7.0 [5.0-11.0] vs. 11.0 [8.0-12.0]; p = 0.009). In adjusted multiple regression analysis, diagnostic factors, including grip strength (B = 0.96, p = 0.04, R2 = 0.19) and SPPB (B = 1.11, p = 0.006, R2 = 0.23), but not muscle mass, were independently associated with fall frequency. CONCLUSIONS: The frequency of falls in HD patients was related to muscle strength and physical function, but not muscle mass.

    DOI： 10.1007/s10157-023-02403-4

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  • プロテオーム解析 Invited

    羽深将人, 山本 卓, 内木宏延, 山本 格, 成田一衛

    64 ( 8 )   863 - 867   2022.12

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  • Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis Reviewed International journal

    Kichitaro Nakajima, Keiichi Yamaguchi, Masahiro Noji, César Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Lianjie Zhou, Hirotsugu Ogi, Toru Ito, Ichiei Narita, Fumitake Gejyo, Hironobu Naiki, Suguru Yamamoto, Yuji Goto

    Nature communications   13 ( 1 )   5689 - 5689   2022.10

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Cold Spring Harbor Laboratory  

    Abstract

    Dialysis-related amyloidosis (DRA), a serious complication among long-term hemodialysis patients, is caused by amyloid fibrils of β<sub>2</sub>-microglobulin (β2m). Although high serum β2m levels and a long dialysis vintage are the primary and secondary risk factors for the onset of DRA, respectively, patients with these do not always develop DRA, indicating that there are additional risk factors. To clarify these unknown factors, we investigated the effects of human sera on β2m amyloid fibril formation. Although sera markedly inhibited amyloid fibril formation, the inhibitory effects were weaker for sera collected from dialysis patients than for control sera. When sera collected before and after maintenance dialysis treatments were compared, the latter inhibited amyloid fibril formation more than the former. These results indicate that, although the inhibitory effects of sera were deteriorated in long-term dialysis patients, they were ameliorated by maintenance dialysis treatments in the short term. Maintenance dialysis decreases the body weight by 5% and consequently increases the concentrations of serum components. Among these components, we found that serum albumin prevented amyloid fibril formation based on macromolecular crowding effects, and that the decreased serum albumin concentration in dialysis patients is a tertiary risk factor for the onset of DRA. The model was constructed assuming accumulative effects of three risk factors and may be useful for predicting the onset of DRA. Furthermore, the model suggested the importance of monitoring temporary and accumulated risks to prevent the development of amyloidoses in general, which occurs based on supersaturation-limited amyloid fibril formation in a crowded milieu.

    DOI： 10.1101/2022.02.01.478730

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  • Dynamic and static balance functions in hemodialysis patients and non-dialysis dependent CKD patients. Reviewed International journal

    Nobuyuki Shirai, Suguru Yamamoto, Yutaka Osawa, Atsuhiro Tsubaki, Shinichiro Morishita, Ichiei Narita

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy   2022.9

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    INTRODUCTION: Chronic kidney disease (CKD) patients undergoing hemodialysis (HD) have a high risk of falls, whereas the impairment in balance function and their types in HD compared with non-dialysis dependent (ND) CKD have not been fully evaluated. METHODS: We conducted a cross-sectional study to assess the balance function in 91 ND-CKD and 65 HD patients. The participants underwent the timed up-and-go test (TUG) to assess dynamic balance and length of the center of pressure (CoP) with open eyes or closed eyes to evaluate static balance. RESULTS: TUG, length of CoP with open eyes, and length of CoP with closed eyes were longer in HD patients compared with those with ND-CKD. Multiple regression analysis showed that dialysis treatment independently affected TUG and length of CoP with open eyes. CONCLUSION: The dynamic and static balance functions are impaired in HD patients compared with that ND-CKD patients. This article is protected by copyright. All rights reserved.

    DOI： 10.1111/1744-9987.13931

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  • Association of the nutritional risk index for Japanese hemodialysis with mortality and dietary nutritional intake in patients undergoing hemodialysis during long-term hospitalization. Reviewed

    Kou Kitabayashi, Suguru Yamamoto, Ichiei Narita

    Clinical and experimental nephrology   26 ( 12 )   1200 - 1207   2022.8

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    AIM: The nutritional risk index for Japanese hemodialysis (NRI-JH) is a nutritional screening tool for predicting mortality in patients undergoing hemodialysis; however, its utility in patients undergoing hemodialysis during long-term hospitalization who have a high risk of protein-energy wasting, is unclear. METHODS: This retrospective study assessed hospitalized patients undergoing hemodialysis during long-term care at a single hospital. The NRI-JH was calculated using body mass index, serum albumin level, total cholesterol level, and serum creatinine level. The patients were categorized into three risk groups-low, medium, and high. Dietary energy and protein intake were evaluated by dietitians. The association of NRI-JH risk with nutritional intake and mortality were examined. RESULTS: In total, 133 patients were analyzed. The NRI-JH risk was low in 24%, medium in 26%, and high in 50% of the patients. The patients in the high-risk group were older and had lower energy and protein intakes than those in the low- and medium-risk groups. High-risk patients showed shorter survival times than low- and medium-risk patients, and a high NRI-JH risk was associated with a high mortality rate (hazard ratio [HR], 2.12; 95% confidence interval [CI], 1.08-4.77; p < 0.05). The association weakened when protein intake and C-reactive protein level were added as covariates (HR, 2.01; 95% CI, 0.95-4.28, p = 0.07). CONCLUSIONS: High NRI-JH risk was associated with low dietary nutritional intake and poor survival in patients undergoing hemodialysis during long-term hospitalization. Nutritional status evaluation and nutritional interventions may improve prognosis in this population.

    DOI： 10.1007/s10157-022-02259-0

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  • Relationship between Nutrition-Related Problems and Falls in Hemodialysis Patients: A Narrative Review Reviewed International journal

    Nobuyuki Shirai, Tatsuro Inoue, Masato Ogawa, Masatsugu Okamura, Shinichiro Morishita, Yamamoto Suguru, Atsuhiro Tsubaki

    Nutrients   14 ( 15 )   3225 - 3225   2022.8

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    Falls are a social problem that increase healthcare costs. Hemodialysis (HD) patients need to avoid falling because fractures increase their risk of death. Nutritional problems such as frailty, sarcopenia, undernutrition, protein-energy wasting (PEW), and cachexia may increase the risk of falls and fractures in patients with HD. This review aimed to summarize the impact of frailty, sarcopenia, undernutrition, PEW, and cachexia on falls in HD patients. The reported global incidence of falls in HD patients is 0.85–1.60 falls per patient per year. HD patients fall frequently, but few reports have investigated the relationship between nutrition-related problems and falls. Several studies reported that frailty and undernutrition increase the risk of falls in HD patients. Nutritional therapy may help to prevent falls in HD patients. HD patients’ falls are caused by nutritional problems such as iatrogenic and non-iatrogenic factors. Falls increase a person’s fear of falling, reducing physical activity, which then causes muscle weakness and further decreased physical activity; this cycle can cause multiple falls. Further research is necessary to clarify the relationships between falls and sarcopenia, cachexia, and PEW. Routine clinical assessments of nutrition-related problems are crucial to prevent falls in HD patients.

    DOI： 10.3390/nu14153225

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  • Dysfunction in dynamic, but not static balance is associated with risk of accidental falls in hemodialysis patients: a prospective cohort study Reviewed International journal

    Shirai N, Yamamoto S, Osawa Y, Tsubaki A, Morishita S, Narita I

    BMC nephrology   23 ( 1 )   237 - 237   2022.7

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Patients with chronic kidney disease undergoing hemodialysis (HD) have a high incidence of falls. Impairment of balance function is a risk factor for falls in the general elderly, and no report examining the association between balance dysfunction and fall incidence in HD patients exists. METHODS: This prospective cohort study was conducted at a single center. The timed-up-and-go test (TUG) as a dynamic balance function was performed and length of the center of pressure (CoP) as a static balance function was measured before and after the HD session at baseline. Data of the number and detailed information of accidental falls for 1 year were collected. Multiple regression analyses were performed to assess the relationships between the number of falls and balance function. RESULTS: Forty-three patients undergoing HD were enrolled in the study. During 1 year of observation, 24 (55.8%) patients experienced accidental falls. TUG time was longer, and CoP was shorter in the post-HD session than in the pre-HD session. Adjusted multiple regression analyses showed that the number of accidental falls was independently associated with TUG time in the pre-HD session (B 0.267, p < 0.001, R2 0.413) and that in the post-HD session (B 0.257, p < 0.001, R2 0.530), but not with CoP. CONCLUSIONS: Dynamic balance was associated with fall incidence in maintenance HD patients. The evaluation and intervention of dynamic balance function might reduce the risk of falls in HD patients. TRIAL REGISTRATION: This study was carried out with the approval of the Niigata Rinko Hospital Ethics Committee (approval number 2005-92) (Registered on December 11, 2019) and registered in The University Hospital Medical Information Network (registration number 000040618 ).

    DOI： 10.1186/s12882-022-02877-6

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  • Medical Director Practice of Advising Increased Dietary Protein Intake in Hemodialysis Patients With Hyperphosphatemia: Associations With Mortality in the Dialysis Outcomes and Practice Patterns Study Reviewed International journal

    Suguru Yamamoto, Brian A. Bieber, Hirotaka Komaba, Norio Hanafusa, Hiroki Kitabayashi, Takanobu Nomura, Aleix Cases, Christian Combe, Ronald L. Pisoni, Bruce M. Robinson, Masafumi Fukagawa

    Journal of Renal Nutrition   32 ( 2 )   243 - 250   2022.2

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    OBJECTIVES: Patients undergoing hemodialysis (HD) may have poor nutritional status and hyperphosphatemia. Nephrologists sometimes manage hyperphosphatemia by prescribing phosphate binders and/or recommending restriction of dietary phosphate including protein-rich foods; the later may, however, adversely affect nutritional status. DESIGN AND METHODS: The analysis includes 8805 HD patients on dialysis ≥ 120 days in 12 countries in Dialysis Outcomes and Practice Patterns Study (DOPPS) phase 4 (2009-2011), from 248 facilities. The primary exposure variable was response to the following question: "For patients with serum albumin 3.0 g/dL and phosphate 6.0 mg/dL, do you recommend to (A) increase or (B) decrease/no change in dietary protein intake (DPI)?". The association between medical director's practice of recommending an increase in DPI and all-cause mortality was analyzed with Cox regression adjusted for potential confounders. Linear and logistic regressions were used to model the cross-sectional associations between DPI advice practice and intermediate markers of patient nutrition. RESULTS: Median follow-up was 1.6 years. In the case scenario, 91% of medical directors in North America had a practice of recommending DPI increase compared to 58% in Europe (range = 36%-83% across 7 countries) and 56% in Japan. The practice of advising DPI increase was weakly associated with lower mortality [HR (95% CI): 0.88 (0.76-1.02)]. The association tended to be stronger in patients with age 70+ years [HR (95% CI): 0.82 (0.69-0.97), P = .12 for interaction]. The practice of advising DPI increase was associated with 0.276 mg/dL higher serum creatinine levels (95% CI: 0.033-0.520) after adjustment for case mix. CONCLUSIONS: Medical director's practice of recommending an increase in DPI for HD patients with low albumin and high phosphate levels was associated with higher serum creatinine levels and potentially lower all-cause mortality. To recommend protein intake liberalization in parallel with phosphate management by physicians may be a critical practice for better nutritional status and outcomes in HD patients.

    DOI： 10.1053/j.jrn.2021.02.007

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  • Magnesium intake by enteral formulation affects serum magnesium concentration in patients undergoing hemodialysis. Reviewed International journal

    Kou Kitabayashi, Suguru Yamamoto, Ichiei Narita

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy   26 ( 4 )   749 - 755   2021.11

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Decreased serum magnesium levels are associated with mortality and fractures in patients with chronic kidney disease; however, there is no recommendation for Mg intake in these populations. This study used cross-sectional analysis to examine the association between Mg intake and serum Mg levels in patients undergoing hemodialysis. Sixty-one patients were included. The daily Mg intake was 185 mg (IQR: 151-203 mg), and serum Mg level was 2.4 mg/dL (IQR: 2.2-2.7 mg/dL). Multiple regression analysis showed that intake of enteral formulation by tube feeding was an independent factor associated with serum Mg level (B = 0.90 [95% confidence interval: 0.61-1.20], p < 0.01). These findings may aid in serum Mg level management through diet and enteral formulation in patients undergoing hemodialysis.

    DOI： 10.1111/1744-9987.13760

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  • Fear of falling and physical activity in hemodialysis patients: a pilot study Reviewed

    Suguru Yamamoto

    Renal Replacement Therapy   7   63   2021.11

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/S41100-021-00383-3

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  • Comparison of muscle strength between hemodialysis patients and non-dialysis patients with chronic kidney disease. Reviewed

    Nobuyuki Shirai, Suguru Yamamoto, Yutaka Osawa, Atsuhiro Tsubaki, Shinichiro Morishita, Kanami Igarashi, Ichiei Narita

    Journal of physical therapy science   33 ( 10 )   742 - 747   2021.10

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    [Purpose] Muscle weakness in patients with chronic kidney disease is associated with several disease-related factors, and this study aimed to examine whether hemodialysis is one of risk factors for muscle weakness in patients with chronic kidney disease. [Participants and Methods] We conducted a cross-sectional study with 74 non-dialysis and 84 hemodialysis patients. Muscle strength evaluations were performed by measuring isometric knee extensor muscle strength and grip strength. Each evaluation item was compared between the hemodialysis and non-dialysis groups, and multiple regression analysis was performed to determine the factors associated with muscle strength. In addition, the correlation between lower-extremity muscle strength and grip strength was examined in each group. [Results] Isometric knee extensor muscle strength was significantly lower in the hemodialysis group than in the non-dialysis group. Grip strength was also significantly lower in the hemodialysis group than in the non-dialysis group. Hemodialysis was determined to be an independent risk factor associated with lower limb muscle strength as well as grip strength. The positive correlation between isometric knee extensor muscle strength and grip strength was almost the same in the groups. [Conclusion] Hemodialysis treatment was an independent risk factor for muscle weakness. Regular monitoring of grip strength may facilitate better management with physical therapy in hemodialysis patients.

    DOI： 10.1589/jpts.33.742

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  • Locomotive syndrome in hemodialysis patients and its association with quality of life-a cross-sectional study Reviewed

    Suguru Yamamoto

    Renal Replacement Therapy   7   36   2021.6

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/S41100-021-00352-W

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  • Serum total indoxyl sulfate and clinical outcomes in hemodialysis patients: results from the Japan Dialysis Outcomes and Practice Patterns Study Reviewed International journal

    Suguru Yamamoto, Douglas S Fuller, Hirotaka Komaba, Takanobu Nomura, Ziad A Massy, Brian Bieber, Bruce Robinson, Ronald Pisoni, Masafumi Fukagawa

    Clinical Kidney Journal   14 ( 4 )   1236 - 1243   2021.4

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

    <title>Abstract</title>
    <sec>
    <title>Background</title>
    Uremic toxins are associated with various chronic kidney disease-related comorbidities. Indoxyl sulfate (IS), a protein-bound uremic toxin, reacts with vasculature, accelerating atherosclerosis and/or vascular calcification in animal models. Few studies have examined the relationship of IS with clinical outcomes in a large cohort of hemodialysis (HD) patients.


    </sec>
    <sec>
    <title>Methods</title>
    We included 1170 HD patients from the Japan Dialysis Outcomes and Practice Patterns Study Phase 5 (2012–15). We evaluated the associations of serum total IS (tIS) levels with all-cause mortality and clinical outcomes including cardiovascular (CV)-, infectious- and malignancy-caused events using Cox regressions.


    </sec>
    <sec>
    <title>Results</title>
    The median (interquartile range) serum tIS level at baseline was 31.6 μg/mL (22.6–42.0). Serum tIS level was positively associated with dialysis vintage. Median follow-up was 2.8 years (range: 0.01–2.9). We observed 174 deaths (14.9%; crude rate, 0.06/year). Serum tIS level was positively associated with all-cause mortality [adjusted hazard ratio per 10 μg/mL higher, 1.16; 95% confidence interval (CI) 1.04–1.28]. Association with cause-specific death or hospitalization events, per 10 μg/mL higher serum tIS level, was 1.18 (95% CI 1.04–1.34) for infectious events, 1.08 (95% CI 0.97–1.20) for CV events and 1.02 (95% CI 0.87–1.21) for malignancy events after adjusting for covariates including several nutritional markers.


    </sec>
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    <title>Conclusions</title>
    In a large cohort study of HD patients, serum tIS level was positively associated with all-cause mortality and infectious events.


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  • pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro Reviewed International journal

    Suguru Yamamoto, Kenichi Sasahara, Mio Domon, Keiichi Yamaguchi, Toru Ito, Shin Goto, Yuji Goto, Ichiei Narita

    Toxins   13 ( 2 )   116 - 116   2021.2

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    Protein-bound uremic toxins (PBUTs) are difficult to remove using conventional dialysis treatment owing to their high protein-binding affinity. As pH changes the conformation of proteins, it may be associated with the binding of uremic toxins. Albumin conformation at pH 2 to 13 was analyzed using circular dichroism. The protein binding behavior between indoxyl sulfate (IS) and albumin was examined using isothermal titration calorimetry. Albumin with IS, and serum with IS, p-cresyl sulfate, indole acetic acid or phenyl sulfate, as well as serum from hemodialysis patients, were adjusted pH of 3 to 11, and the concentration of the free PBUTs was measured using mass spectrometry. Albumin was unfolded at pH &lt; 4 or &gt;12, and weakened interaction with IS occurred at pH &lt; 5 or &gt;10. The concentration of free IS in the albumin solution was increased at pH 4.0 and pH 11.0. Addition of human serum to each toxin resulted in increased free forms at acidic and alkaline pH. The pH values of serums from patients undergoing hemodialysis adjusted to 3.4 and 11.3 resulted in increased concentrations of the free forms of PBUTs. In conclusion, acidic and alkaline pH conditions changed the albumin conformation and weakened the protein binding property of PBUTs in vitro.

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  • Inorganic polyphosphate potentiates lipopolysaccharide-induced macrophage inflammatory response. Reviewed International journal

    Toru Ito, Suguru Yamamoto, Keiichi Yamaguchi, Mami Sato, Yoshikatsu Kaneko, Shin Goto, Yuji Goto, Ichiei Narita

    The Journal of biological chemistry   295 ( 12 )   4014 - 4023   2020.3

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    Inorganic polyphosphate (polyP) is a linear polymer of orthophosphate units that are linked by phosphoanhydride bonds and is involved in various pathophysiological processes. However, the role of polyP in immune cell dysfunction is not well-understood. In this study, using several biochemical and cell biology approaches, including cytokine assays, immunofluorescence microscopy, receptor-binding assays with quartz crystal microbalance, and dynamic light scanning, we investigated the effect of polyP on in vitro lipopolysaccharide (LPS)-induced macrophage inflammatory response. PolyP up-regulated LPS-induced production of the inflammatory cytokines, such as tumor necrosis factor α, interleukin-1β, and interleukin-6, in macrophages, and the effect was polyP dose- and chain length-dependent. However, orthophosphate did not exhibit this effect. PolyP enhanced the LPS-induced intracellular macrophage inflammatory signals. Affinity analysis revealed that polyP interacts with LPS, inducing formation of small micelles, and the polyP-LPS complex enhanced the binding affinity of LPS to Toll-like receptor 4 (TLR4) on macrophages. These results suggest that inorganic polyP plays a critical role in promoting inflammatory response by enhancing the interaction between LPS and TLR4 in macrophages.

    DOI： 10.1074/jbc.RA119.011763

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  • Adsorption of Protein-Bound Uremic Toxins Using Activated Carbon through Direct Hemoperfusion in vitro Reviewed

    Suguru Yamamoto, Toru Ito, Mami Sato, Shin Goto, Junichiro J. Kazama, Fumitake Gejyo, Ichiei Narita

    Blood Purification   48 ( 3 )   215 - 222   2019

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    DOI： 10.1159/000500014

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  • Mineral and bone disorder management in hemodialysis patients: comparing PTH control practices in Japan with Europe and North America: the Dialysis Outcomes and Practice Patterns Study (DOPPS) Reviewed

    Yamamoto Suguru, Karaboyas Angelo, Komaba Hirotaka, Taniguchi Masatomo, Nomura Takanobu, Bieber Brian A, De Sequera Patricia, Christensson Anders, Pisoni Ronald L, Robinson Bruce M, Fukagawa Masafumi

    BMC NEPHROLOGY   19 ( 1 )   2018.10

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    DOI： 10.1186/s12882-018-1056-5

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  • Molecular mechanisms underlying uremic toxin-related systemic disorders in chronic kidney disease: focused on β2-microglobulin-related amyloidosis and indoxyl sulfate-induced atherosclerosis—Oshima Award Address 2016 Reviewed

    Suguru Yamamoto

    Clinical and Experimental Nephrology   23 ( 2 )   1 - 7   2018.6

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    DOI： 10.1007/s10157-018-1588-9

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  • Indoxyl sulfate promotes macrophage il-1β production by activating aryl hydrocarbon receptor/nf-κ/mapk cascades, but the nlrp3 inflammasome was not activated Reviewed

    Takuya Wakamatsu, Suguru Yamamoto, Toru Ito, Yoko Sato, Koji Matsuo, Yoshimitsu Takahashi, Yoshikatsu Kaneko, Shin Goto, Junichiro James Kazama, Fumitake Gejyo, Ichiei Narita

    Toxins   10 ( 3 )   2018.3

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    DOI： 10.3390/toxins10030124

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  • Adsorption of Protein-Bound Uremic Toxins Through Direct Hemoperfusion With Hexadecyl-Immobilized Cellulose Beads in Patients Undergoing Hemodialysis Reviewed

    Suguru Yamamoto, Mami Sato, Yoko Sato, Takuya Wakamatsu, Yoshimitsu Takahashi, Akira Iguchi, Kentaro Omori, Yasushi Suzuki, Isei Ei, Yoshikatsu Kaneko, Shin Goto, Junichiro J. Kazama, Fumitake Gejyo, Ichiei Narita

    Artificial Organs   42 ( 1 )   88 - 93   2018.1

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    DOI： 10.1111/aor.12961

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  • Uremic Toxicity and Bone in CKD Reviewed

    Suguru Yamamoto, Masafumi Fukagawa

    JOURNAL OF NEPHROLOGY   30 ( 5 )   623 - 627   2017.10

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    DOI： 10.1007/s40620-017-0406-x

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  • Direct hemoperfusion with β2-microglobulin adsorption column for patients with end-stage kidney disease

    Suguru Yamamoto, Junichro J. Kazama

    Hemoperfusion, Plasmaperfusion and Other Clinical Uses of General, Biospecific, Immuno and Leucocyte Adsorbents   4   285 - 296   2017.4

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Part of collection (book)   Publisher：World Scientific Publishing Co. Pte. Ltd.  

    DOI： 10.1142/9919

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  • Hemodiafiltration for hepatic encephalopathy induced by Budd-Chiari syndrome in a patient with end-stage kidney disease. Reviewed

    Wakamatsu T, Yamamoto S, Kamimura K, Nakatsue T, Iino N, Iguchi S, Kaneko Y, Goto S, Kazama JJ, Narita I

    CEN case reports   5 ( 2 )   125 - 130   2016.11

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    DOI： 10.1007/s13730-015-0209-7

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  • The macrophage and its related cholesterol efflux as a HDL function index in atherosclerosis Reviewed

    Suguru Yamamoto, Ichiei Narita, Kazuhiko Kotani

    CLINICA CHIMICA ACTA   457   117 - 122   2016.6

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    DOI： 10.1016/j.cca.2016.04.012

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  • Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype Reviewed

    Suguru Yamamoto, Jiayong Zhong, Patricia G. Yancey, Yiqin Zuo, MacRae F. Linton, Sergio Fazio, Haichun Yang, Ichiei Narita, Valentina Kon

    ATHEROSCLEROSIS   242 ( 1 )   56 - 64   2015.9

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    DOI： 10.1016/j.atherosclerosis.2015.06.055

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  • Continuous Reduction of Protein-Bound Uraemic Toxins with Improved Oxidative Stress by Using the Oral Charcoal Adsorbent AST-120 in Haemodialysis Patients Reviewed

    Suguru Yamamoto, Junichiro J. Kazama, Kentaro Omori, Koji Matsuo, Yoshimitsu Takahashi, Kazuko Kawamura, Takayuki Matsuto, Hiroshi Watanabe, Toru Maruyama, Ichiei Narita

    SCIENTIFIC REPORTS   5   14381   2015.9

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    DOI： 10.1038/srep14381

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  • Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate Reviewed

    Koji Matsuo, Suguru Yamamoto, Takuya Wakamatsu, Yoshimitsu Takahashi, Kazuko Kawamura, Yoshikatsu Kaneko, Shin Goto, Junichiro J. Kazama, Ichiei Narita

    TOXINS   7 ( 8 )   3155 - 3166   2015.8

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    DOI： 10.3390/toxins7083155

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  • Risk Score to Predict 1-Year Mortality after Haemodialysis Initiation in Patients with Stage 5 Chronic Kidney Disease under Predialysis Nephrology Care Reviewed

    Toshiki Doi, Suguru Yamamoto, Takatoshi Morinaga, Ken-ei Sada, Noriaki Kurita, Yoshihiro Onishi

    PLOS ONE   10 ( 6 )   e0129180   2015.6

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    DOI： 10.1371/journal.pone.0129180

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  • Use of Renin-Angiotensin System Inhibitors Is Associated with Reduction of Fracture Risk in Hemodialysis Patients Reviewed

    Suguru Yamamoto, Ryo Kido, Yoshihiro Onishi, Shingo Fukuma, Tadao Akizawa, Masafumi Fukagawa, Junichiro J. Kazama, Ichiei Narita, Shunichi Fukuhara

    PLOS ONE   10 ( 4 )   e0122691   2015.4

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    DOI： 10.1371/journal.pone.0122691

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  • Chronic kidney disease induced dysfunction of high density lipoprotein Reviewed

    Suguru Yamamoto, Valentina Kon

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   18 ( 2 )   251 - 254   2014.4

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    DOI： 10.1007/s10157-013-0857-x

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  • Autophagy: a two-edged sword in diabetes mellitus. Reviewed

    Yamamoto S, Kazama JJ, Fukagawa M

    The Biochemical journal   456 ( 3 )   e1 - 3   2013.12

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  • Dysfunctional High-Density Lipoprotein in Patients on Chronic Hemodialysis Reviewed

    Suguru Yamamoto, Patricia G. Yancey, Alp Ikizler, W. Gray Jerome, Ryohei Kaseda, Brian Cox, Aihua Bian, Ayumi Shintani, Agnes B. Fogo, MacRae F. Linton, Sergio Fazio, Valentina Kon

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   60 ( 23 )   2372 - 2379   2012.12

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    DOI： 10.1016/j.jacc.2012.09.013

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  • β2-Microglobulin Reviewed

    Suguru Yamamoto, Junichiro James Kazama, Hiroki Maruyama, Ichiei Narita, Fumitake Gejyo

    Uremic Toxins   249 - 258   2012.9

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    DOI： 10.1002/9781118424032.ch16

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  • Macrophage Polarization by Angiotensin II-Type 1 Receptor Aggravates Renal Injury-Acceleration of Atherosclerosis Reviewed

    Suguru Yamamoto, Patricia G. Yancey, Yiqin Zuo, Li-Jun Ma, Ryohei Kaseda, Agnes B. Fogo, Iekuni Ichikawa, MacRae F. Linton, Sergio Fazio, Valentina Kon

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   31 ( 12 )   2856 - U277   2011.12

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    DOI： 10.1161/ATVBAHA.111.237198

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  • Oral activated charcoal adsorbent (AST-120) ameliorates extent and instability of atherosclerosis accelerated by kidney disease in apolipoprotein E-deficient mice Reviewed

    Suguru Yamamoto, Yiqin Zuo, Ji Ma, Patricia G. Yancey, Tracy E. Hunley, Masaru Motojima, Agnes B. Fogo, MacRae F. Linton, Sergio Fazio, Iekuni Ichikawa, Valentina Kon

    NEPHROLOGY DIALYSIS TRANSPLANTATION   26 ( 8 )   2491 - 2497   2011.8

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    DOI： 10.1093/ndt/gfq759

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  • Recent progress in understanding dialysis-related amyloidosis Reviewed

    Suguru Yamamoto, Junichiro James Kazama, Ichiei Narita, Hironobu Naiki, Fumitake Gejyo

    BONE   45   S39 - S42   2009.7

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    DOI： 10.1016/j.bone.2009.03.655

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  • Mechanisms for increased cardiovascular disease in chronic kidney dysfunction Reviewed

    Suguru Yamamoto, Valentina Kon

    CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION   18 ( 3 )   181 - 188   2009.5

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    DOI： 10.1097/MNH.0b013e328327b360

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  • Patients undergoing dialysis therapy for 30 years or more survive with serious osteoarticular disorders Reviewed

    S. Yamamoto, J. J. Kazama, H. Maruyama, S. Nishi, I. Narita, F. Gejyo

    CLINICAL NEPHROLOGY   70 ( 6 )   496 - 502   2008.12

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  • Historical background and clinical treatment of dialysis-related amyloidosis Reviewed

    S Yamamoto, F Gejyo

    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS   1753 ( 1 )   4 - 10   2005.11

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    DOI： 10.1016/j.bbapap.2005.09.006

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  • Kinetic analysis of the polymerization and depolymerization of beta(2)-microglobulin-related amyloid fibrils in vitro. Reviewed

    Yamamoto S, Hasegawa K, Yamaguchi I, Goto Y, Gejyo F, Naiki H

    Biochimica et biophysica acta   1753 ( 1 )   34 - 43   2005.11

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  • Low concentrations of sodium dodecyl sulfate induce the extension of beta(2)-microglobulin-related amyloid fibrils at a neutral pH Reviewed

    S Yamamoto, K Hasegawa, Yamaguchi, I, S Tsutsumi, J Kardos, Y Goto, F Gejyo, H Naiki

    BIOCHEMISTRY   43 ( 34 )   11075 - 11082   2004.8

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    DOI： 10.1021/bi049262u

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  • Glycosaminoglycans enhance the trifluoroethanol-induced extensionof beta(2)-microglobulin-related amyloid fibrils at a neutral pH Reviewed

    S Yamamoto, Yamaguchi, I, K Hasegawa, S Tsutsumi, Y Goto, F Gejyo, H Naiki

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   15 ( 1 )   126 - 133   2004.1

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    DOI： 10.1097/01.ASN.0000103228.81623.C7

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  • High peritoneal clearance of small molecules did not provide low serum beta(2)-microglobulin concentrations in peritoneal dialysis patients Reviewed

    S Yamamoto, A Kasai, H Shimada

    PERITONEAL DIALYSIS INTERNATIONAL   23   S34 - S36   2003

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  • Impact of Dialysis Duration and Frailty on Frailty Progression: A Japanese Nationwide Cohort Study

    Kakuya Niihata, Noriaki Kurita, Ryohei Inanaga, Tatsunori Toida, Masanori Abe, Takao Masaki, Suguru Yamamoto

    2025.6

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  • An end-stage kidney disease patient undergoing dialysis treatment for 50 years with dialysis-related amyloidosis in multiple organs

    Toru Ito, Takashi Kato, Suguru Yamamoto, Hisaki Shimada, Hideyuki Kabasawa, Shin Goto, Riuko Ohashi, Ichiei Narita

    CEN Case Reports   2025.6

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    DOI： 10.1007/s13730-025-01003-3

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  • Genetic and protein structure prediction analyses identify a rare pathogenic PKD1 variant causing autosomal dominant polycystic kidney disease.

    Takamitsu Shiiya, Hirofumi Watanabe, Ryo Aida, Tadashi Otsuka, Ryohei Kaseda, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Ichiei Narita

    CEN case reports   2025.3

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    Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenic kidney disorders. The diagnosis of ADPKD requires imaging findings showing multiple kidney cysts or genetic testing, in cases where a family history is unknown. We report a patient diagnosed with ADPKD based on the identification of a rare PKD1 variant. The patient was a 41-year-old female in whom cysts and calcification in the kidneys were incidentally detected. Whole-exome sequencing identified a rare PKD1 variant (NM_001009944.3: c.11557G > A/p.E3853K). Protein structure prediction of the PKD1-PKD2 complex showed that the variant may be pathogenic, leading to the diagnosis of autosomal dominant polycystic kidney disease. A detailed family history revealed that her relatives also had ADPKD, further supporting the diagnosis of ADPKD. Comprehensive genetic analysis and protein structure prediction led to the diagnosis of ADPKD and the identification of rare causative genes. These methods are useful for diagnosing hereditary kidney diseases of unknown etiologies.

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  • Peristaltic pump-triggered amyloid formation suggests shear stresses are in vivo risks for amyloid nucleation

    Yuji Goto, Tomoki Ota, Wenlou Yuan, Ikuko Yumen, Keiichi Yamaguchi, Hirokazu Matsuda, Suguru Yamamoto, Hirotsugu Ogi

    npj Biosensing   2 ( 1 )   2025.1

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    DOI： 10.1038/s44328-025-00027-0

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  • Nutritional changes in patients undergoing hemodialysis who develop COVID-19

    Kou Kitabayashi, Suguru Yamamoto, Shin Goto

    Renal Replacement Therapy   2025.1

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    DOI： 10.1186/s41100-024-00600-9

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  • Response to Letter to the Editor: Is the “Nutritional Risk Index for Japanese Hemodialysis” Validated as a Nutritional and Prognostic Indicator?

    Katsuhito Mori, Yosuke Yamamoto, Norio Hanafusa, Suguru Yamamoto, Shingo Fukuma, Yoshihiro Onishi, Masanori Emoto, Masaaki Inaba

    Journal of Renal Nutrition   2025

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    DOI： 10.1053/j.jrn.2024.12.004

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  • Systemic AA amyloidosis with amyloid deposition in the peritoneum at the time of initiating peritoneal dialysis

    Suguru Yamamoto

    CEN Case Reports   2025

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    DOI： 10.1007/S13730-025-00981-8

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  • Nephrotic syndrome induces the upregulation of cell proliferation-related genes in tubular cells in mice

    Yuya Suzuki, Ryohei Kaseda, Yusuke Nakagawa, Hirofumi Watanabe, Tadashi Otsuka, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Taiji Matsusaka, Ichiei Narita

    Clinical and Experimental Nephrology   2024.12

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    Abstract

    Background

    Massive proteinuria, dyslipidemia, and hypoalbuminemia induced by nephrotic syndrome (NS) secondarily affect tubular cells. We conducted an RNA sequencing (RNA-seq) analysis using a mouse model of focal segmental glomerulosclerosis to clarify the impact of NS on tubular cells.

    Methods

    We used transgenic mice expressing hCD25 in podocytes (Nep25) to induce NS by injecting human CD25-specific immunotoxin (LMB2) at a dose of 0.625 ng/g body weight. Seven days after LMB2 injection, we extracted RNA from the whole kidney and conducted an RNA-seq analysis. Subsequently, we conducted multiple immunostaining and in situ hybridization (ISH) of differentially expressed genes (DEGs) to identify their locations and associated cell types. We also investigated the expression levels of DEGs in an additional mouse model of NS induced by adriamycin.

    Results

    After NS induction, 562 upregulated and 430 downregulated DEGs were identified using RNA-seq. An enrichment analysis revealed the upregulation of cell proliferation-related genes. We observed significant upregulation of Foxm1, a transcription factor linked to cell proliferation. Immunostaining and ISH showed that various tubular cells expressed Mki67 and Foxm1 during NS development. The adriamycin-induced NS model also demonstrated the upregulation of Mki67 and Foxm1 in tubular cells.

    Conclusions

    NS induced the upregulation of cell proliferation-related genes in tubular cells without detectable renal dysfunction. Our findings may contribute to understanding the pathological effects of nephrotic syndrome on tubular cells.

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  • Fanconi syndrome with acute proximal tubular injury induced by a dietary supplement containing beni-koji: a case series report. International journal

    Masato Habuka, Michihiro Hosojima, Yusuke Yata, Kenshiro Kurumada, Moeri Yamagiwa, Masataka Yonezawa, Masanori Sudo, Hideyuki Kabasawa, Asa Ogawa, Hitomi Hama, Yumi Ito, Naofumi Imai, Suguru Yamamoto, Akihiko Saito, Shin Goto

    BMC nephrology   25 ( 1 )   446 - 446   2024.12

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    BACKGROUND: Fanconi syndrome is a disorder of the proximal tubule that leads to malabsorption of various electrolytes and substances and is a common consequence of drug-induced nephrotoxicity. However, cases of dietary supplement-induced Fanconi syndrome are rare, and detailed reports on the evaluation of renal histology in patients with this syndrome are lacking. CASE PRESENTATION: We present two cases of dietary supplement-induced Fanconi syndrome that was confirmed by kidney biopsy. Based on their medical history and laboratory and histological findings, both cases were diagnosed as acute proximal tubular injury caused by ingestion of a lipid-lowering dietary supplement containing beni-koji leading to Fanconi syndrome. After discontinuation of the dietary supplement and correction of dehydration and electrolyte imbalance, renal function completely recovered in one case but progressed to chronic kidney disease in the other. CONCLUSIONS: Clinicians should consider dietary supplement-induced Fanconi syndrome as a differential diagnosis in patients who become ill while taking a dietary supplement. Kidney biopsy is useful for diagnosing acute tubular injury with Fanconi syndrome and investigating its pathogenesis. Patients who have developed dietary supplement-induced Fanconi syndrome require long-term monitoring to detect and prevent progression to chronic kidney disease.

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  • Ectopic Production of Parathyroid Hormone and Production of Parathyroid Hormone-related Protein in Dedifferentiated Endometrial Carcinoma Induced Severe Hypercalcemia.

    Takeru Ogino, Hirofumi Watanabe, Shoko Yamazaki, Megumi Kurosawa, Akiko Kobayashi, Naofumi Imai, Takahiro Taguchi, Hajime Umezu, Ryo Aida, Kazuki Watanabe, Tadashi Otsuka, Hideyuki Kabasawa, Ryohei Kaseda, Suguru Yamamoto, Kosuke Yoshihara, Shin Goto, Ichiei Narita

    Internal medicine (Tokyo, Japan)   2024.9

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    Hypercalcemia is a significant complication in cancer patients, primarily caused by parathyroid hormone-related peptide (PTHrP) and, rarely, by parathyroid hormone (PTH) production from tumors. We report a case of severe hypercalcemia in a woman with uterine cancer who exhibited elevated PTH and PTHrP levels. Surgical intervention revealed dedifferentiated endometrial carcinoma. Postoperatively, PTH and PTHrP levels normalized but subsequently increased due to metastases. A molecular analysis confirmed the expression of the PTH gene and protein within the tumor, indicating ectopic PTH production. In diagnosing and treating cancers, it is necessary to consider not only PTHrP production but also ectopic PTH production.

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  • 網羅的遺伝子解析と蛋白構造予測で病原PKD1バリアントを同定し常染色体顕性(優性)多発性嚢胞腎と診断した一例

    椎谷 貴光, 渡辺 博文, 相田 涼, 大塚 忠司, 忰田 亮平, 山本 卓, 金子 佳賢, 後藤 眞

    日本腎臓学会誌   66 ( 6-E )   899 - 899   2024.9

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  • 近位尿細管に限局した上皮細胞障害を呈したサプリメントによるファンコニー症候群の1例

    羽深 将人, 蒲澤 秀門, 細島 康宏, 小川 麻, 山本 卓, 伊藤 由美, 今井 直史, 後藤 眞

    日本腎臓学会誌   66 ( 6-E )   892 - 892   2024.9

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  • マルチビタミンの長期過剰摂取による高Ca血症の遷延と二次性シュウ酸腎症を認めた一例

    入沢 大喜, 逸見 太郎, 後藤 佐和子, 蒲澤 秀門, 細島 康宏, 伊藤 由美, 今井 直史, 山本 卓, 後藤 眞, 成田 一衛

    日本腎臓学会誌   66 ( 6-E )   889 - 889   2024.9

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  • The combined effect of leucine-enriched essential amino acid supplements and locomotion training on physical functions and quality of life in hemodialysis patients

    Kou Kitabayashi, Suguru Yamamoto, Yumi Katano, Ichiei Narita

    Renal Replacement Therapy   2024.6

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    DOI： 10.1186/s41100-024-00551-1

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  • Frailty and Duration of Maintenance Dialysis: A Japanese Nationwide Cross-Sectional Study Reviewed

    Suguru Yamamoto

    American Journal of Kidney Diseases   (in press)   2024.6

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    DOI： 10.1053/J.AJKD.2024.04.012

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  • Indoxyl Sulfate-Induced Macrophage Toxicity and Therapeutic Strategies in Uremic Atherosclerosis

    Takuya Wakamatsu, Suguru Yamamoto, Shiori Yoshida, Ichiei Narita

    Toxins   2024.5

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    DOI： 10.3390/toxins16060254

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  • Effectiveness of calcimimetics on fractures in dialysis patients with secondary hyperparathyroidism: meta-analysis of randomized trials Reviewed

    Takuya Wakamatsu, Suguru Yamamoto, Koji Matsuo, Masatomo Taniguchi, Takayuki Hamano, Masafumi Fukagawa, Junichiro James Kazama

    Journal of Bone and Mineral Metabolism   2024.5

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    DOI： 10.1007/s00774-024-01500-y

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  • Protein intake and its relationship with frailty in chronic kidney disease Reviewed

    Nobuyuki Shirai, Suguru Yamamoto, Yutaka Osawa, Atsuhiro Tsubaki, Shinichiro Morishita, Toshiko Murayama, Ichiei Narita

    Clinical and Experimental Nephrology   2024.5

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    DOI： 10.1007/s10157-023-02452-9

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  • シングルルーメンカテーテル有用性の検討

    吉澤 優太, 大塚 忠司, 山本 卓, 永野 敦嗣, 甲田 亮, 飯野 則昭, 宮崎 慧, 若松 拓也, 飯田 倫理, 青柳 竜治, 伊藤 徹, 亀田 茂美

    日本透析医学会雑誌   57 ( Suppl.1 )   619 - 619   2024.5

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  • Polyacrylic acid-polyvinylpyrrolidone complex for achieving hemostasis after hemodialysis: study protocol for an open-label crossover randomized controlled trial (PAA-PVP study)

    Ryohei Terashima, Mototsugu Tanaka, Atsushi Hashimoto, Daiki Omori, Takahiro Tanaka, Haruna Miyazawa, Masahiro Ishizawa, Yoshihiko Tomita, Tomoko Ito, Yoshiyuki Koyama, Kokichi Saito, Suguru Yamamoto, Shin Goto, Ichiei Narita

    2024.4

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  • 慢性腎臓病における感染症の重症化に関連する因子の検討

    若松 拓也, 山本 卓, 成田 一衛

    新潟県医師会報   ( 888 )   8 - 9   2024.3

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  • Supersaturation, a critical factor underlying proteostasis of amyloid fibril formation. International journal

    Yuji Goto, Kichitaro Nakajima, Suguru Yamamoto, Keiichi Yamaguchi

    Journal of molecular biology   168475 - 168475   2024.2

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    From a physicochemical viewpoint, amyloid fibril formation is a phase transition from soluble to crystal-like sates limited by supersaturation. It occurs only above solubility (i.e., the solubility limit) coupled with a breakdown of supersaturation. Although many studies have examined the role of molecular chaperones in the context of proteostasis, the role of supersaturation has not been addressed. Moreover, although molecular chaperone-dependent disaggregations have been reported for preformed amyloid fibrils, amyloid fibrils will not dissolve above the solubility of monomers, even if agitations fragment long fibrils to shorter amyloid particles. On the other hand, on considering a reversible and coupled equilibrium of interactions, folding/unfolding and amyloid formation/disaggregation, molecules stabilizing native states can work as a disaggregase reversing the amyloid fibrils to monomers. It is likely that the proteostasis network has various intra- and extracellular components which disaggregate preformed amyloid fibrils as well as prevent amyloid formation. Further studies with a view of solubility and supersaturation will be essential for comprehensive understanding of proteostasis.

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  • Mass spectrometry-based proteomic analysis of proteins adsorbed by hexadecyl-immobilized cellulose bead column for the treatment of dialysis-related amyloidosis Reviewed

    Suguru Yamamoto

    Amyloid: the International Journal of Experimental and Clinical Investigation: the Official Journal of the International Society of Amyloidosis   2024

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1080/13506129.2024.2315148

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  • Association of Nutritional Risk Index With Infection-Related Hospitalization and Death After Hospitalization in Patients Undergoing Maintenance Hemodialysis

    Katsuhito Mori, Yosuke Yamamoto, Norio Hanafusa, Suguru Yamamoto, Shingo Fukuma, Yoshihiro Onishi, Masanori Emoto, Masaaki Inaba

    Journal of Renal Nutrition   2024

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    DOI： 10.1053/j.jrn.2024.07.017

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  • A case of multiorgan failure due to carbamazepine intoxication successfully treated with multimodal blood purification therapy

    Suguru Yamamoto

    CEN Case Reports   2024

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    DOI： 10.1007/S13730-024-00900-3

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  • <i>Tsukamurella conjunctivitidis</i> peritonitis diagnosed by 16S rRNA gene sequencing in a patient undergoing peritoneal dialysis

    Suguru Yamamoto

    CEN Case Reports   2024

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    DOI： 10.1007/S13730-024-00958-Z

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  • シングルルーメンカテーテルの有用性について

    吉澤 優太, 大塚 忠司, 山本 卓, 永野 敦嗣, 甲田 亮, 飯野 則昭, 宮崎 慧, 若松 拓也, 飯田 倫理, 青柳 竜治, 伊藤 徹, 亀田 茂美, 成田 一衛

    Niigata Blood Purification Conferenceプログラム・一般演題抄録   2023   10 - 10   2023.12

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  • Frailty in Patients on Dialysis Surviving for More than 40 Years is Common and Severe: A Nationwide Cross-Sectional Study

    Yamamoto Suguru, Niihata Kakuya, Toida Tatsunori, Abe Masanori, Hanafusa Norio, Kurita Noriaki

    SSRN   2023.10

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  • Active vitamin D use and fractures in hemodialysis patients: Results from the international DOPPS. Reviewed International journal

    Hirotaka Komaba, Junhui Zhao, Angelo Karaboyas, Suguru Yamamoto, Indranil Dasgupta, Mohamed Hassan, Li Zuo, Anders Christensson, Christian Combe, Bruce Robinson M, Masafumi Fukagawa

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research   2023.9

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    Active vitamin D is commonly used to control secondary hyperparathyroidism in dialysis patients, but it is unknown whether active vitamin D directly improves bone strength, independent of its effect to suppress parathyroid hormone (PTH). We analyzed the association between prescription of active vitamin D and incidence of any fracture and hip fracture in 41,677 in-center hemodialysis patients from 21 countries in phases 3-6 (2005-2018) of the Dialysis Outcomes and Practice Patterns Study (DOPPS). We used Cox regression, adjusted for PTH and other potential confounders, and used a per-protocol approach to censor patients at treatment switch during follow-up. We also used a facility preference approach to minimize confounding by indication. Overall, 55% of patients were prescribed active vitamin D at study enrollment. Event rates (per patient-year) were 0.024 for any fracture and 0.010 for hip fracture. The adjusted hazard ratio (95% confidence interval) comparing patients prescribed vs. not prescribed active vitamin D was 1.02 (0.90-1.17) for any fracture and 1.00 (0.81-1.23) for hip fracture. In the facility preference approach, there was no difference in fracture rate between facilities with higher vs. lower active vitamin D prescriptions. Thus, our results do not suggest a PTH-independent benefit of active vitamin D in fracture prevention and support the current KDIGO guideline suggesting the use of active vitamin D only in subjects with elevated or rising PTH. Further research is needed to determine the role of active vitamin D beyond PTH control. This article is protected by copyright. All rights reserved.

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  • A Case of Systemic Amyloid A Amyloidosis Secondary to Xanthogranulomatous Pyelonephritis. Reviewed

    Masato Habuka, Mizusa Nishikiori, Chihiro Oikawa, Megumi Takahashi, Yuichi Sakamaki, Asa Ogawa, Norio Miyajima, Yasuhiko Tanabe, Keiichi Honma, Kunihiko Wakaki, Suguru Yamamoto, Ichiei Narita

    Internal medicine (Tokyo, Japan)   2023.7

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    The combination of systemic amyloid A (AA) amyloidosis and xanthogranulomatous pyelonephritis (XGP) resulting from a chronic urinary tract infection is extremely rare. We herein report a case of systemic AA amyloidosis secondary to XGP for which clinical remission developed after nephrectomy. To our knowledge, this is the first case report describing the clinical improvement of systemic AA amyloidosis secondary XGP after nephrectomy in Japan. Clinicians should be aware of this uncommon combination and search for amyloid depositions in cases of XGP.

    DOI： 10.2169/internalmedicine.1806-23

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  • Sodium magnetic resonance imaging shows impairment of the counter-current multiplication system in diabetic mice kidney. Reviewed International journal

    Yusuke Nakagawa, Ryohei Kaseda, Yuya Suzuki, Hirofumi Watanabe, Tadashi Otsuka, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Yasuhiko Terada, Tomoyuki Haishi, Susumu Sasaki, Ichiei Narita

    Kidney360   4 ( 5 )   582 - 590   2023.3

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    Sodium magnetic resonance imaging can non-invasively assess sodium distribution, specifically sodium concentration in the countercurrent multiplication system in the kidney, which forms a sodium concentration gradient from the cortex to the medulla, enabling efficient water reabsorption. This study aimed to investigate whether sodium magnetic resonance imaging can detect changes in sodium concentrations under normal conditions in mice and in disease models such as a mouse model with diabetes mellitus. Methods: We performed sodium and proton nuclear magnetic resonance imaging using a 9.4-T vertical standard-bore super-conducting magnet. Results: A condition of deep anesthesia, with widened breath intervals, or furosemide administration in 6-week-old C57BL/6JJcl mice showed a decrease in both tissue sodium concentrations in the medulla and sodium concentration gradients from the cortex to the medulla. Further, sodium magnetic resonance imaging revealed reductions in the sodium concentration of the medulla and in the gradient from the cortex to the medulla in BKS.Cg-Leprdb+/+ Leprdb/Jcl mice at very early type-2 diabetes mellitus stages compared to corresponding control BKS.Cg-m+/m+/Jcl mice. Conclusions: The kidneys of BKS.Cg-Leprdb+/+ Leprdb/Jcl mice aged 6 weeks showed impairments in the countercurrent multiplication system. We propose the utility of 23Na MRI for evaluating functional changes in diabetic kidney disease, not as markers that reflect structural damage. Thus, 23Na MRI may be a potential very early marker for structures beyond the glomerulus; this may prompt intervention with novel efficacious tubule-targeting therapies.

    DOI： 10.34067/KID.0000000000000072

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  • Assessing fluid volume and determining outcomes of acute heart failure using plasma human atrial natriuretic peptide. Reviewed

    Yuya Suzuki, Tadashi Otsuka, Yuki Yoshioka, Tomomichi Iida, Shingo Maruyama, Hirofumi Watanabe, Ryohei Kaseda, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Ryuji Aoyagi, Ichiei Narita

    Clinical and experimental nephrology   27 ( 6 )   565 - 573   2023.3

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    BACKGROUND: The post-dialysis plasma level of human atrial natriuretic peptide (hANP) reflects the fluid volume in patients on hemodialysis. The threshold hANP level is reportedly 100 pg/mL; however, the clinical usefulness of the threshold hANP level for volume control has not been sufficiently studied. METHODS: We conducted a single-center, retrospective, observational study that included 156 hemodialysis patients without atrial fibrillation. First, we examined the usefulness of the threshold hANP level (100 pg/mL) for predicting hypoxemia due to congestion in a short-term observational study from December 30, 2015 to January 5, 2016. Subsequently, we conducted a 5-year follow-up study wherein the outcomes were hospitalization due to acute heart failure (AHF), development of cardiovascular diseases (CVD), and all-cause death. Finally, we collected echocardiography data to investigate the relationship between cardiac function and hANP. RESULTS: Our short-term observational study showed that patients with an hANP level ≥ 100 pg/mL developed hypoxemia due to congestion (odds ratio, 3.52; 95% confidence interval, 1.06-11.71; P = 0.040). At the 5-year follow-up, patients with an hANP level ≥ 100 pg/mL had significantly higher rates of hospitalization due to AHF, CVD, and all-cause death based on the log-rank test (P = 0.003, P = 0.019, P < 0.001, respectively). Cardiac disfunctions were significantly associated with the high hANP level. CONCLUSIONS: The hANP level is indicative of both fluid volume and cardiac dysfunction. A threshold hANP level of 100 pg/mL can serve as a predictive marker for AHF and a practical indicator for volume control.

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  • THE EVALUATION OF FLUID VOLUME AND PROGNOSIS IN HEMODIALYSIS PATIENTS UTILIZING PLASMA HUMAN ATRIAL NATRIURETIC PEPTIDE

    Suguru Yamamoto

    Nephrology Dialysis Transplantation   2023

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  • Secondary hyperparathyroidism, weight loss, and longer term mortality in haemodialysis patients: results from the DOPPS Reviewed International journal

    Hirotaka Komaba, Junhui Zhao, Suguru Yamamoto, Takanobu Nomura, Douglas S. Fuller, Keith P. McCullough, Pieter Evenepoel, Anders Christensson, Xinju Zhao, Mona Alrukhaimi, Fadwa Al‐Ali, Eric W. Young, Bruce M. Robinson, Masafumi Fukagawa

    Journal of Cachexia, Sarcopenia and Muscle   12 ( 4 )   855 - 865   2021.8

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    BACKGROUND: Wasting is a common complication of kidney failure that leads to weight loss and poor outcomes. Recent experimental data identified parathyroid hormone (PTH) as a driver of adipose tissue browning and wasting, but little is known about the relations among secondary hyperparathyroidism, weight loss, and risk of mortality in dialysis patients. METHODS: We included 42,319 chronic in-centre haemodialysis patients from the Dialysis Outcomes and Practice Patterns Study phases 2-6 (2002-2018). Linear mixed models were used to estimate the association between baseline PTH and percent weight change over 12 months, adjusting for country, demographics, comorbidities, and labs. Accelerated failure time models were used to assess 12 month weight loss as a mediator between baseline high PTH and mortality after 12 months. RESULTS: Baseline PTH was inversely associated with 12 month weight change: 12 month weight loss >5% was observed in 21%, 18%, 18%, 17%, 15%, and 14% of patients for PTH ≥600 pg/mL, 450-600, 300-450, 150-300, 50-150, and <50 pg/mL, respectively. In adjusted analyses, 12 month weight change compared with PTH 150-299 pg/mL was -0.60%, -0.12%, -0.10%, +0.15%, and +0.35% for PTH ≥600, 450-600, 300-450, 50-150, and <50 pg/mL, respectively. This relationship was robust regardless of recent hospitalization and was more pronounced in persons with preserved appetite. During follow-up after the 12 month weight measure [median, 1.0 (interquartile range, 0.6-1.7) years; 6125 deaths], patients with baseline PTH ≥600 pg/mL had 11% [95% confidence interval (CI), 9-13%] shorter lifespan, and 18% (95% CI, 14-23%) of this effect was mediated through weight loss ≥2.5%. CONCLUSIONS: Secondary hyperparathyroidism may be a novel mechanism of wasting, corroborating experimental data, and, among chronic dialysis patients, this pathway may be a mediator between elevated PTH levels and mortality. Future research should determine whether PTH-lowering therapy can limit weight loss and improve longer term dialysis outcomes.

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jcsm.12722

  • Erratum to: Aberrant mucosal immunoreaction to tonsillar microbiota in immunoglobulin A nephropathy. International journal

    Hiroki Yamaguchi, Shin Goto, Nao Takahashi, Masafumi Tsuchida, Hirofumi Watanabe, Suguru Yamamoto, Yoshikatsu Kaneko, Koichi Higashi, Hiroshi Mori, Yukio Nakamura, Arata Horii, Ken Kurokawa, Ichiei Narita

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   2021.1

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    DOI： 10.1093/ndt/gfaa319

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  • Aberrant mucosal immunoreaction to tonsillar microbiota in immunoglobulin A nephropathy Reviewed International journal

    Hiroki Yamaguchi, Shin Goto, Nao Takahashi, Masafumi Tsuchida, Hirofumi Watanabe, Suguru Yamamoto, Yoshikatsu Kaneko, Koichi Higashi, Hiroshi Mori, Yukio Nakamura, Arata Horii, Ken Kurokawa, Ichiei Narita

    Nephrology Dialysis Transplantation   36 ( 1 )   75 - 86   2021.1

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    <title>Abstract</title>
    <sec>
    <title>Background</title>
    Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis worldwide, characterized by mesangial polymeric IgA1 deposition. IgAN is believed to develop owing to aberrant mucosal immunoreaction against commensals in the tonsils. However, the exact interrelation between pathogenic IgA and mucosal microbiota in IgAN patients is unclear.


    </sec>
    <sec>
    <title>Methods</title>
    Biopsy-proven IgAN or recurrent tonsillitis (RT) patients who had undergone tonsillectomy were enrolled. We used 16S ribosomal RNA gene amplicon sequencing with a flow cytometry-based bacterial cell sorting technique) and immunoglobulin repertoire sequencing of the IgA heavy chain to characterize IgA-coated bacteria of the tonsillar microbiota (IgA-SEQ) and their corresponding IgA repertoire. Furthermore, we fractionated patient serum using gel-filtration chromatography and performed flow cytometry-based analysis of IgA binding to bacteria cultured from incised tonsils.


    </sec>
    <sec>
    <title>Results</title>
    Tonsillar proliferation-inducing ligand and B-cell activating factor levels were significantly higher in IgAN than in RT patients. IgA-SEQ for tonsillar microbiota revealed the preferential binding ability of IgA to Bacteroidetes in IgAN tonsils compared with those from RT patients. Expression of immunoglobulin heavy (IGH) constant alpha 1 with IGH variable 3–30 was significantly higher in IgAN than that in RT, and positively correlated with the IgA-coated enrichment score of Bacteroidetes. Serum polymeric IgA, comprising high levels of GdIgA1, exhibited considerable binding to Bacteroidetes strains cultured from the tonsils of IgAN patients.


    </sec>
    <sec>
    <title>Conclusions</title>
    These findings provide evidence that aberrant mucosal immune responses to tonsillar anaerobic microbiota, primarily consisting of members of the phylum Bacteroidetes, are involved in IgAN pathophysiology.


    </sec>

    DOI： 10.1093/ndt/gfaa223

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  • Type-I Angiotensin II Receptor Blockade Reduces Uremia-induced Deterioration of Bone Material Properties. Reviewed International journal

    Takuya Wakamatsu, Yoshiko Iwasaki, Suguru Yamamoto, Koji Matsuo, Shin Goto, Ichiei Narita, Junichiro J Kazama, Kennichi Tanaka, Akemi Ito, Ryosuke Ozasa, Takayoshi Nakano, Chisato Miyakoshi, Yoshihiro Onishi, Shingo Fukuma, Shunichi Fukuhara, Hideyuki Yamato, Masafumi Fukagawa, Tadao Akizawa

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research   36 ( 1 )   67 - 79   2020.8

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    Chronic kidney disease (CKD) is associated with a high incidence of fractures. However, the pathophysiology of this disease is not fully understood, and limited therapeutic interventions are available. This study aimed to determine the impact of type-1 angiotensin II receptor blockade (AT-1RB) on preventing CKD-related fragility fractures and elucidate its pharmacological mechanisms. AT-1RB use was associated with a lower risk of hospitalization due to fractures in 3276 patients undergoing maintenance hemodialysis. In nephrectomized rats, administration of olmesartan suppressed osteocyte apoptosis, skeletal pentosidine accumulation and apatite disorientation, and partially inhibited the progression of the bone elastic mechanical properties, while the bone mass unchanged. Olmesartan suppressed angiotensin II-dependent oxidation stress and apoptosis in primary cultured osteocytes in vitro. In conclusion, angiotensin II-dependent intraskeletal oxidation stress deteriorated the bone elastic mechanical properties by promoting osteocyte apoptosis and pentosidine accumulation. Thus, AT-1RB contributes to the underlying pathogenesis of abnormal bone quality in the setting of CKD, possibly by oxidative stress.

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  • FGF23 and mortality among prevalent hemodialysis patients in the Japan Dialysis Outcomes and Practice Patterns Study Reviewed

    Hirotaka Komaba, Douglas S. Fuller, Masatomo Taniguchi, Suguru Yamamoto, Takanobu Nomura, Junhui Zhao, Brian A. Bieber, Bruce M. Robinson, Ronald L. Pisoni, Masafumi Fukagawa

    Kidney International Reports   2020.8

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    DOI： 10.1016/j.ekir.2020.08.013

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  • Effect of sucroferric oxyhydroxide on gastrointestinal microbiome and uremic toxins in patients with chronic kidney disease undergoing hemodialysis. Reviewed

    Akira Iguchi, Suguru Yamamoto, Akira Oda, Kenichi Tanaka, Junichiro James Kazama, Takako Saeki, Hajime Yamazaki, Ken Ishioka, Tatsuo Suzutani, Ichiei Narita

    Clinical and experimental nephrology   24 ( 8 )   725 - 733   2020.4

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    BACKGROUND: In patients with chronic kidney disease (CKD), dysbiosis in the gastrointestinal microbiome is thought to be associated with increased production of uremic toxins, such as indoxyl sulfate (IS) and p-cresyl sulfate (PCS). Sucroferric oxyhydroxide (SFO), an iron-based phosphate binder, may affect the gastrointestinal microbiome and the production of uremic toxins. We aimed to examine whether SFO administration affected distribution of gastrointestinal microbiome and serum uremic toxin levels in CKD patients undergoing hemodialysis. METHODS: In this single-center, open-label, interventional study, 18 maintenance hemodialysis patients with hyperphosphatemia were prescribed with SFO. We collected serum samples before and after 3 months of administration, and serum levels of IS and PCS were measured. A control group of 20 hemodialysis patients without SFO was evaluated. We evaluated gastrointestinal microbiome of patients pre- and post-SFO administration by 16S rDNA sequencing and bioinformatics analysis. RESULTS: Serum IS and PCS levels were significantly elevated after administration of SFO (IS before 2.52 ± 1.60 mg/dl vs. after 3.13 ± 1.51 mg/dl, P = 0.008; PCS before 2.32 ± 2.44 mg/dl vs. after 3.45 ± 2.11 mg/dl, P = 0.002), while serum IS and PCS levels did not change in the control group. Microbiome analysis in the SFO group showed no significant change in diversity and major components in phylum, class, order, family, gene, and species. CONCLUSION: Administration of SFO increased the serum levels of IS and PCS with no change of major components of gastrointestinal microbiome.

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  • SEVERITY OF PRURITUS IN HEMODIALYSIS PATIENTS: RELATIONSHIP TO UREMIC TOXINS AND DIALYSIS MODALITY

    Suguru Yamamoto

    Nephrology Dialysis Transplantation   2020

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  • PRIORITIZATION BY MEDICAL DIRECTORS OF NUTRITIONAL PROTEIN VERSUS DIETARY PHOSPHORUS CONTROL IN HEMODIALYSIS PATIENTS: ASSOCIATION WITH MORTALITY IN THE DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (DOPPS)

    Suguru Yamamoto

    Nephrology Dialysis Transplantation   2020

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    DOI： 10.1093/NDT/GFAA142|III1769

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  • 血液透析患者における透析実施時間帯の早朝空腹時呼吸商に及ぼす影響の検討

    北林 紘, 片野 佑美, 山本 卓, 石井 雄士

    日本栄養士会雑誌   62 ( 12 )   641 - 647   2019.12

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  • Disrupted tubular parathyroid hormone/parathyroid hormone receptor signaling and damaged tubular cell viability possibly trigger postsurgical kidney injury in patients with advanced hyperparathyroidism. Reviewed

    Sato T, Kikkawa Y, Yamamoto S, Tanaka Y, Kazama JJ, Tominaga Y, Ichimori T, Okada M, Hiramitsu T, Fukagawa M

    Clinical kidney journal   12 ( 5 )   686 - 692   2019.10

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    DOI： 10.1093/ckj/sfy136

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  • Possible mechanisms of polyphosphate-induced amyloid fibril formation of beta(2)-microglobulin Reviewed

    Suguru Yamamoto

    Proceedings of the National Academy of Sciences   116 ( 26 )   12833 - 12838   2019.6

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  • The features of bone articular lesions in dialysis-related amyloidosis (DRA) and criteria for the clinical diagnosis of DRA Reviewed

    Suguru Yamamoto

    Renal Replacement Therapy   2019.5

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    DOI： 10.1186/S41100-019-0205-Z

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  • Cryofibrinogen-associated glomerulonephritis diagnosed by mass spectrometry and immunoelectron microscopy Reviewed

    Masanori Sudo, Yuichi Sakamaki, Michihiro Hosojima, Suguru Yamamoto, Yumi Ito, Naofumi Imai, Yoshikatsu Kaneko, Shin Goto, Chih Ping Li, Akira Shimizu, Ichiei Narita

    Human Pathology: Case Reports   15   83 - 87   2019.3

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  • Successful treatment of gamma 1 heavy chain deposition disease with bortezomib and dexamethasone

    Suguru Yamamoto

    Human Pathology: Case Reports   2019

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    DOI： 10.1016/J.EHPC.2019.01.001

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  • Attenuated Macrophage Infiltration in Glomeruli of Aged Mice Resulting in Ameliorated Kidney Injury in Nephrotoxic Serum Nephritis. Reviewed

    Kaneko Y, Cho T, Sato Y, Goto K, Yamamoto S, Goto S, Madaio MP, Narita I

    The journals of gerontology. Series A, Biological sciences and medical sciences   73 ( 9 )   1178 - 1186   2018.8

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  • 自己末梢血幹細胞移植後に血栓性微小血管症(TMA)による腎障害を合併した一例

    白柏 由佳, 後藤 佐和子, 細島 康宏, 保坂 聖子, 山本 卓, 今井 直史, 伊藤 由美, 後藤 眞, 成田 一衛

    日本腎臓学会誌   60 ( 6 )   876 - 876   2018.8

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  • Multicentre cross-sectional study for bone-articular lesions associated with dialysis related amyloidosis in Japan. Reviewed

    Nishi S, Hoshino J, Yamamoto S, Goto S, Fujii H, Ubara Y, Motomiya Y, Morita H, Takaichi K, Yamagata K, Shigematsu T, Ueda M, Ando Y

    Nephrology (Carlton, Vic.)   23 ( 7 )   640 - 645   2018.7

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  • ABO血液型不適合生体腎移植前に行った二重膜濾過血漿交換施行中に全身膨隆疹を発症した一例

    宮内 大輔, 斎藤 将名, 土田 良樹, 谷江 駿矢, 近藤 友希, 長谷川 進, 西塔 毅, 田崎 正行, 中川 由紀, 齋藤 和英, 蒲澤 秀門, 山本 卓, 成田 一衛

    日本臨床工学技士会会誌   ( 63 )   194 - 194   2018.4

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  • Fatal visceral disseminated varicella zoster infection during initial remission induction therapy in a patient with lupus nephritis and rheumatoid arthritis - Possible association with mycophenolate mofetil and high-dose glucocorticoid therapy: A case report Reviewed

    Masato Habuka, Yoko Wada, Yoichi Kurosawa, Suguru Yamamoto, Yusuke Tani, Riuko Ohashi, Yoichi Ajioka, Masaaki Nakano, Ichiei Narita

    BMC Research Notes   11 ( 1 )   165   2018.3

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    DOI： 10.1186/s13104-018-3271-3

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  • Kidney morphological parameters measured using noncontrast-enhanced steady-state free precession MRI with spatially selective inversion recovery pulse correlate with eGFR in patients with advanced CKD Reviewed

    Tadashi Otsuka, Yoshikatsu Kaneko, Yuya Sato, Ryohei Kaseda, Ryuji Aoyagi, Suguru Yamamoto, Shin Goto, Ichiei Narita

    Clinical and Experimental Nephrology   22 ( 1 )   45 - 54   2018.2

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    DOI： 10.1007/s10157-017-1413-x

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  • INDOXYL SULFATE AND MORTALITY IN HAEMODIALYSIS PATIENTS: RESULTS FROM THE JAPAN DIALYSIS OUTCOMESAND PRACTICE PATTERNS STUDY (J-DOPPS)

    Suguru Yamamoto

    Nephrology Dialysis Transplantation   2018

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  • Suction towards a vessel wall by hemodialysis catheters—the establishment of a new experimental extracorporeal circulation system using pig veins

    Suguru Yamamoto

    Renal Replacement Therapy   2018

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    DOI： 10.1186/S41100-018-0161-Z

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  • ヘキサデキル基固定セルロースビーズによる蛋白結合尿毒症物質の吸着効果

    山本 卓, 佐藤 茉美, 佐藤 容子, 若松 拓也, 高橋 良光, 井口 昭, 大森 健太郎, 鈴木 靖, 惠 以盛, 金子 佳賢, 後藤 眞, 風間 順一郎, 下條 文武, 成田 一衛

    日本透析医会雑誌   32 ( 3 )   516 - 519   2017.12

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  • Effect of ferric citrate hydrate on FGF23 and PTH levels in patients with non-dialysis-dependent chronic kidney disease with normophosphatemia and iron deficiency Reviewed

    Akira Iguchi, Suguru Yamamoto, Mihoko Yamazaki, Kazuyuki Tasaki, Yasushi Suzuki, Junichiro James Kazama, Ichiei Narita

    Clinical and Experimental Nephrology   22 ( 4 )   1 - 8   2017.11

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    DOI： 10.1007/s10157-017-1510-x

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  • 原因不明の低Na血症および急性肺水腫に対してCHDFが奏功した一例

    村竹 佑太, 黒澤 陽一, 若松 拓也, 細島 康宏, 保坂 聖子, 山本 卓, 後藤 眞, 成田 一衛

    新潟急性血液浄化研究会抄録集   4回   6 - 7   2017.11

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  • Prevalence of Earlobe Creases and Their Association With History of Cardiovascular Disease in Patients Undergoing Hemodialysis: A Cross-Sectional Study Reviewed

    Minako Wakasugi, Junichiro James Kazama, Kazuko Kawamura, Suguru Yamamoto, Masaaki Nagai, Kentaro Omori, Saori Yokota, Hirokazu Fujikawa, Ikuo Aoike, Tsukasa Omori, Ichiei Narita

    Therapeutic Apheresis and Dialysis   21 ( 5 )   478 - 484   2017.10

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    DOI： 10.1111/1744-9987.12567

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  • Initiation of Sevelamer and Mortality among Hemodialysis Patients Treated with Calcium-Based Phosphate Binders Reviewed

    Hirotaka Komaba, Mia Wang, Masatomo Taniguchi, Suguru Yamamoto, Takanobu Nomura, Douglas E. Schaubel, Abigail R. Smith, Jarcy Zee, Angelo Karaboyas, Brian Bieber, Masafumi Fukagawa, Francesca Tentori

    CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   12 ( 9 )   1489 - 1497   2017.9

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    DOI： 10.2215/CJN.13091216

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  • ボルテゾミブが奏功した意義不明の単クローン性ガンマグロブリン血症(MGUS)に伴う重鎖沈着症(HCDD)の一例

    須藤 真則, 若松 拓也, 石川 友美, 羽深 将人, 細島 康宏, 山本 卓, 伊藤 由美, 今井 直史, 金子 佳賢, 瀧澤 淳, 成田 一衛

    日本腎臓学会誌   59 ( 6 )   869 - 869   2017.9

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  • Potential Benefit Associated With Delaying Initiation of Hemodialysis in a Japanese Cohort. Reviewed International journal

    Higuchi S, Nakaya I, Yoshikawa K, Chikamatsu Y, Sada KE, Yamamoto S, Takahashi S, Sasaki H, Soma J

    Kidney international reports   2 ( 4 )   594 - 602   2017.7

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    DOI： 10.1016/j.ekir.2017.01.015

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  • Prolactin Upregulates Female-Predominant P450 Gene Expressions and Downregulates Male-Predominant Gene Expressions in Mouse Liver Reviewed

    Yuya Sato, Yoshikatsu Kaneko, Takamasa Cho, Kei Goto, Tadashi Otsuka, Suguru Yamamoto, Shin Goto, Hiroki Maruyama, Ichiei Narita

    DRUG METABOLISM AND DISPOSITION   45 ( 6 )   586 - 592   2017.6

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    DOI： 10.1124/dmd.116.074658

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  • Comparison of methods of steroid administration combined with tonsillectomy for IgA nephropathy patients Reviewed

    Hirofumi Watanabe, Shin Goto, Daisuke Kondo, Takuma Takata, Hajime Yamazaki, Michihiro Hosojima, Suguru Yamamoto, Yoshikatsu Kaneko, Ryuji Aoyagi, Ichiei Narita

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   21 ( 2 )   257 - 265   2017.4

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    DOI： 10.1007/s10157-016-1282-8

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  • インドキシル硫酸はマクロファージのAhR/NF-κB/MAPK系を活性化させる一方、NLRP3インフラマソーム活性を抑制する

    若松 拓也, 山本 卓, 松尾 浩司, 金子 佳賢, 後藤 眞, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   59 ( 3 )   283 - 283   2017.4

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  • レニン-アンギオテンシン系阻害は腎不全ラットの破骨細胞活性を抑制し、石灰化障害を改善させる

    佐藤 容子, 若松 拓也, 山本 卓, 伊藤 明美, 岩崎 香子, 金子 佳賢, 後藤 眞, 深川 雅史, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   59 ( 3 )   276 - 276   2017.4

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  • Net cholesterol efflux capacity of HDL enriched serum and coronary atherosclerosis in rheumatoid arthritis Reviewed

    Suguru Yamamoto

    IJC Metabolic & Endocrine   13   6 - 11   2016.12

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    DOI： 10.1016/J.IJCME.2016.08.002

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  • 透析非導入に至った超高齢者慢性腎臓病患者の1例

    山本 卓, 吉澤 優太, 後藤 慧, 高井 千夏, 酒巻 裕一, 金子 佳賢, 後藤 眞, 風間 順一郎, 丸山 弘樹, 成田 一衛

    日本老年医学会雑誌   53 ( 4 )   447 - 448   2016.10

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  • [Teriparatide:benefit and safety for bone disease in CKD patients undergoing hemodialysis]. Reviewed

    Yamamoto S, Ei I, Narita I

    Clinical calcium   26 ( 9 )   1301 - 1307   2016.9

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  • Extracapillary proliferation and arteriolar hyalinosis are associated with long-term kidney survival in IgA nephropathy Reviewed

    Yoshikatsu Kaneko, Kazuhiro Yoshita, Emiko Kono, Yumi Ito, Naofumi Imai, Suguru Yamamoto, Shin Goto, Ichiei Narita

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   20 ( 4 )   569 - 577   2016.8

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    DOI： 10.1007/s10157-015-1185-0

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  • 治療中に播種性水痘感染を発症したループス腎炎の2例

    羽深 将人, 永野 敦嗣, 細島 康宏, 山本 卓, 中枝 武司, 和田 庸子, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   58 ( 6 )   779 - 779   2016.8

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  • 血液透析導入後に腎生検を施行しIgA腎症と診断した一例

    熊木 隆之, 石川 友美, 羽深 将人, 細島 康宏, 山本 卓, 今井 直史, 伊藤 由美, 風間 順一郎, 成田 一衛

    日本透析医学会雑誌   49 ( Suppl.1 )   583 - 583   2016.5

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  • ヘキサデシル基固定セルロースビーズは蛋白結合尿毒症物質を吸着する

    山本 卓, 風間 順一郎, 佐藤 茉美, 若松 拓也, 高橋 良光, 惠 以盛, 大森 健太郎, 井口 昭, 鈴木 靖, 成田 一衛

    日本透析医学会雑誌   49 ( Suppl.1 )   530 - 530   2016.5

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  • レニン-アンギオテンシン系阻害は腎不全ラットの骨石灰化と弾性を改善させる

    若松 拓也, 山本 卓, 松尾 浩司, 岩崎 香子, 伊藤 明美, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   58 ( 3 )   293 - 293   2016.5

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  • Leptin deficiency down-regulates IL-23 production in glomerular podocytes resulting in an attenuated immune response in nephrotoxic serum nephritis Reviewed

    Kei Goto, Yoshikatsu Kaneko, Yuya Sato, Tadashi Otsuka, Suguru Yamamoto, Shin Goto, Keiko Yamamoto, Tadashi Yamamoto, Hiroshi Kawachi, Michael P. Madaio, Ichiei Narita

    INTERNATIONAL IMMUNOLOGY   28 ( 4 )   197 - 208   2016.4

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    DOI： 10.1093/intimm/dxv067

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  • Is IgA nephropathy (IgAN) a familial or sporadic disease? Reviewed

    Ichiei Narita, Yoshikatsu Kaneko, Yumi Itoh, Yuichi Sakamaki, Seitaro Iguchi, Suguru Yamamoto, Minako Wakasugi, Junichiro J. Kazama, Shin Goto

    Pathogenesis and Treatment in IgA Nephropathy: An International Comparison   43 - 51   2016.3

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    DOI： 10.1007/978-4-431-55588-9_3

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  • Removal of uremic toxins by renal replacement therapies: a review of current progress and future perspectives

    Suguru Yamamoto

    Renal Replacement Therapy   2016

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    DOI： 10.1186/S41100-016-0056-9

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  • Intact parathyroid hormone and whole parathyroid hormone assay results disagree in hemodialysis patients under cinacalcet hydrochloride therapy Reviewed

    Ryo Koda, Junichiro James Kazama, Koji Matsuo, Kazuko Kawamura, Suguru Yamamoto, Minako Wakasugi, Tetsuro Takeda, Ichiei Narita

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   19 ( 4 )   710 - 717   2015.8

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    DOI： 10.1007/s10157-014-1045-3

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  • 生体腎移植2例が長期生着中の家族性巣状分節性糸球体硬化症の1家系

    坪野 俊介, 酒巻 裕一, 山本 卓, 今井 直史, 伊藤 由美, 田崎 正行, 中川 由紀, 齋藤 和英, 後藤 眞, 高橋 公太, 成田 一衛

    日本腎臓学会誌   57 ( 6 )   947 - 947   2015.8

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  • TAFRO症候群に合併した急性腎障害に対してCRRTを要した1例

    須藤 真則, 酒巻 裕一, 若松 彩子, 渡辺 博文, 蒲澤 秀門, 山本 卓, 金子 佳賢, 山崎 肇, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   57 ( 6 )   951 - 951   2015.8

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  • Advanced Thymic Cancer Treated with Carboplatin and Paclitaxel in a Patient Undergoing Hemodialysis Reviewed

    Satoru Miura, Hiroshi Kagamu, Takehito Sakai, Koichiro Nozaki, Katsuaki Asakawa, Hiroshi Moro, Masaaki Okajima, Satoshi Watanabe, Suguru Yamamoto, Noriaki Iino, Shin Goto, Junichiro James Kazama, Hirohisa Yoshizawa, Ichiei Narita

    INTERNAL MEDICINE   54 ( 1 )   55 - 58   2015

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    DOI： 10.2169/internalmedicine.54.3484

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  • Administration of Ferric Citrate Hydrate Decreases Circulating FGF23 Levels Independently of Serum Phosphate Levels in Hemodialysis Patients with Iron Deficiency Reviewed

    Akira Iguchi, Junichiro J. Kazama, Suguru Yamamoto, Kazuhiro Yoshita, Yasuo Watanabe, Noriaki Iino, Ichiei Narita

    NEPHRON   131 ( 3 )   161 - 166   2015

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    DOI： 10.1159/000440968

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  • ブタ静脈血管を用いた短期カテーテルの評価システムの開発に関する検討

    髙橋 良光, 風間 順一郎, 山本 卓, 成田 一衛, 追手 巍

    日本透析医学会雑誌   48 ( 6 )   393 - 394   2015

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    DOI： 10.4009/jsdt.48.393

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  • 経皮的腎動脈形成術により腎機能の著明な改善が得られた片側腎動脈狭窄の一例

    大塚 忠司, 酒巻 裕一, 山本 卓, 金子 佳賢, 伊藤 由美, 今井 直史, 成田 一衛, 猪俣 繁, 捧 博輝

    日本腎臓学会誌   56 ( 6 )   863 - 863   2014.8

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  • A hip fracture in a dialysis patient with A beta 2M amyloidosis Reviewed

    Junichiro J. Kazama, Suguru Yamamoto, Minako Wakasugi, Ichiei Narita

    KIDNEY INTERNATIONAL   85 ( 1 )   214 - 215   2014.1

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  • 肝性脳症による意識障害が血液透析濾過により改善しえたバッド・キアリ症候群合併透析患者の一例

    若松 拓也, 矢田 雄介, 山本 卓, 中枝 武司, 飯野 則昭, 後藤 眞, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   55 ( 6 )   1045 - 1045   2013.8

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  • Cause-specific excess mortality among dialysis patients: Comparison with the general population in Japan Reviewed

    Minako Wakasugi, Junichiro James Kazama, Suguru Yamamoto, Kazuko Kawamura, Ichiei Narita

    Therapeutic Apheresis and Dialysis   17 ( 3 )   298 - 304   2013.6

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    DOI： 10.1111/j.1744-9987.2012.01144.x

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  • 血液透析患者に合併した進行期胸腺癌に対し全身化学療法を施行した1例

    片桐 隆幸, 三浦 理, 山崎 美穂子, 山本 卓, 坂井 勇仁, 飯野 則昭, 後藤 眞, 各務 博, 風間 順一郎, 成田 一衛

    日本透析医学会雑誌   46 ( Suppl.1 )   547 - 547   2013.5

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  • 新潟県における腹膜透析医療の実際

    飯野 則昭, 山本 卓, 川村 和子, 後藤 眞, 風間 順一郎, 丸山 弘樹, 成田 一衛

    日本透析医学会雑誌   46 ( Suppl.1 )   769 - 769   2013.5

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  • 腹膜透析患者におけるESA切替用量の検討、新潟県内多施設共同研究

    飯野 則昭, 川村 和子, 山本 卓, 後藤 眞, 丸山 弘樹, 風間 順一郎, 成田 一衛

    日本透析医学会雑誌   46 ( Suppl.1 )   913 - 913   2013.5

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  • A combination of healthy lifestyle factors is associated with a decreased incidence of chronic kidney disease: A population-based cohort study Reviewed

    Minako Wakasugi, Junichiro J. Kazama, Suguru Yamamoto, Kazuko Kawamura, Ichiei Narita

    Hypertension Research   36 ( 4 )   328 - 333   2013.4

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    DOI： 10.1038/hr.2012.186

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  • [Kidney and bone update : the 5-year history and future of CKD-MBD. Treatment for dialysis-related amyloidosis update]. Reviewed

    Yamamoto S, Kazama JJ, Narita I

    Clinical calcium   22 ( 7 )   1089 - 1098   2012.7

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  • High Mortality Rate of Infectious Diseases in Dialysis Patients: A Comparison With the General Population in Japan Reviewed

    Minako Wakasugi, Kazuko Kawamura, Suguru Yamamoto, Junichiro James Kazama, Ichiei Narita

    THERAPEUTIC APHERESIS AND DIALYSIS   16 ( 3 )   226 - 231   2012.6

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    DOI： 10.1111/j.1744-9987.2012.01062.x

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  • Hypogammaglobulinemic Patient with Polyarthritis Mimicking Rheumatoid Arthritis Finally Diagnosed as Septic Arthritis Caused by Mycoplasma hominis Reviewed

    Hiroe Sato, Noriaki Iino, Riuko Ohashi, Takako Saeki, Tomoyuki Ito, Maki Saito, Yutaka Tsubata, Suguru Yamamoto, Shuichi Murakami, Takeshi Kuroda, Yoshinari Tanabe, Junichi Fujisawa, Takehiro Murai, Masaaki Nakano, Ichiei Narita, Fumitake Gejyo

    INTERNAL MEDICINE   51 ( 4 )   425 - 429   2012

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    DOI： 10.2169/internalmedicine.51.6058

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  • Nuclear Chromatin-concentrated Osteoblasts in Renal Bone Diseases Reviewed

    Junichiro James Kazama, Suguru Yamamoto, Ichiei Narita, Satoshi Kurihara

    THERAPEUTIC APHERESIS AND DIALYSIS   15   9 - 13   2011.6

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    DOI： 10.1111/j.1744-9987.2011.00919.x

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  • Cancellous Bone Volume Is an Indicator for Trabecular Bone Connectivity in Dialysis Patients Reviewed

    Junichiro James Kazama, Ryo Koda, Suguru Yamamoto, Ichiei Narita, Fumitake Gejyo, Akihide Tokumoto

    CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   5 ( 2 )   292 - 298   2010.2

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    DOI： 10.2215/CJN.04150609

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  • Comparison of Quantitative Cancellous Bone Connectivity Analyses at Two- and Three-Dimensional Levels in Dialysis Patients Reviewed

    Junichiro James Kazama, Ryo Koda, Suguru Yamamoto, Ichiei Narita, Fumitake Gejyo, Akihide Tokumoto

    CALCIFIED TISSUE INTERNATIONAL   84 ( 1 )   38 - 44   2009.1

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    DOI： 10.1007/s00223-008-9194-6

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  • The Risk of Gallbladder Stone Formation Is Increased in Patients with Predialysis Chronic Kidney Disease but Not Those Undergoing Chronic Hemodialysis Therapy Reviewed

    Junichiro James Kazama, Sakumi Kazama, Ryo Koda, Suguru Yamamoto, Ichiei Narita, Fumitake Gejyo

    NEPHRON CLINICAL PRACTICE   111 ( 3 )   C167 - C172   2009

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    DOI： 10.1159/000199456

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  • The Risk of Gallbladder Stone Formation Is Increased in Patients with Predialysis Chronic Kidney Disease but Not Those Undergoing Chronic Hemodialysis Therapy Reviewed

    Suguru Yamamoto

    Nephron Clinical Practice   111 ( 3 )   c167 - 72   2009

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    DOI： 10.1159/000199456

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  • Alterations in serum phosphate levels predict the long-term response to intravenous calcitriol therapy in dialysis patients with secondary hyperparathyroidism Reviewed

    Kiyoko Hosaka, Junichiro James Kazama, Suguru Yamamoto, Yumi Ito, Noriaki Iino, Hiroki Maruyama, Akihiko Saito, Ichiei Narita, Fumitake Gejyo

    JOURNAL OF BONE AND MINERAL METABOLISM   26 ( 2 )   185 - 190   2008.3

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    DOI： 10.1007/s00774-007-0809-1

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  • [Mechanism of beta(2)-microglobulin-related amyloid fibril formation in CKD]. Reviewed

    Yamamoto S, Kazama JJ

    Clinical calcium   17 ( 5 )   740 - 744   2007.5

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  • Circulating osteoprotegerin affects bone metabolism in dialysis patients with mild secondary hyperparathyroidism Reviewed

    JJ Kazama, K Omori, S Yamamoto, Y Ito, H Maruyama, Narita, I, F Gejyo, Y Iwasaki, M Fukagawa

    THERAPEUTIC APHERESIS AND DIALYSIS   10 ( 3 )   262 - 266   2006.6

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    DOI： 10.1111/j.1744-9987.2006.00375.x

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  • A beta-2M-amyloidosis and related bone diseases Reviewed

    JJ Kazama, S Yamamoto, N Takahashi, Y Ito, H Maruyama, Narita, I, F Gejyo

    JOURNAL OF BONE AND MINERAL METABOLISM   24 ( 2 )   182 - 184   2006.3

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  • Pretreatment plasma intact parathyroid hormone and serum calcium levels, but not serum phosphate levels, predict the response to maxacalcitol therapy in dialysis patients with secondary hyperparathyroidism Reviewed

    Yuko Oyama, Junichiro James Kazama, Kentaro Omori, Noboru Higuchi, Shigemi Kameda, Suguru Yamamoto, Yumi Ito, Hiroki Maruyama, Ichiei Narita, Fumitake Gejyo

    Clinical and Experimental Nephrology   9 ( 2 )   142 - 147   2005.6

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    DOI： 10.1007/s10157-005-0342-2

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  • Molecular interactions in the formation and deposition of beta(2)-microglobuhn-related amyloid fibrils Reviewed

    H Naiki, S Yamamoto, K Hasegawa, Yamaguchi, I, Y Goto, F Gejyo

    AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS   12 ( 1 )   15 - 25   2005.3

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  • Pretreatment serum FGF-23 levels predict the efficacy of calcitriol therapy in dialysis patients Reviewed

    JJ Kazama, F Sato, K Omori, H Hama, S Yamamoto, H Maruyama, Narita, I, F Gejyo, T Yamashita, S Fukumoto, M Fukagawa

    KIDNEY INTERNATIONAL   67 ( 3 )   1120 - 1125   2005.3

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    DOI： 10.1111/j.1523-1755.2005.00178.x

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  • Direct comparison between two 1-84PTH assays in dialysis patients. Reviewed

    Kazama JJ, Yamamoto S, Kameda S, Maruyama H, Narita I, Shigematsu T, Gejyo F

    Nephron. Clinical practice   99 ( 1 )   c8 - 12   2005

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  • Direct comparison between two 1-84PTH assays in dialysis patients Reviewed

    JJ Kazama, S Yamamoto, S Kameda, H Maruyama, Narita, I, T Shigematsu, F Gejyo

    NEPHRON CLINICAL PRACTICE   99 ( 1 )   C8 - C12   2005

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    DOI： 10.1159/000081788

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  • Glycosaminoglycan and proteoglycan inhibit the depolymerization of beta(2)-microglobulin amyloid fibrils in vitro Reviewed

    Yamaguchi, I, H Suda, N Tsuzuike, K Seto, M Seki, Y Yamaguchi, K Hasegawa, N Takahashi, S Yamamoto, F Gejyo, H Naiki

    KIDNEY INTERNATIONAL   64 ( 3 )   1080 - 1088   2003.9

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    DOI： 10.1046/j.1523-1755.2003.00167.x

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  • Successful perioperative blood purification therapy in patients with maintenance hemodialysis therapy who underwent living donor liver transplantation Reviewed

    JJ Kazama, N Takahashi, Y Ito, Y Watanabe, N Iino, S Iguchi, A Oyanagi, H Obayashi, S Ito, H Maruyama, Narita, I, S Yamamoto, Y Sato, A Tsuchiya, T Ichida, F Gejyo

    CLINICAL NEPHROLOGY   59 ( 3 )   229 - 233   2003.3

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  • Molecular remission induced by fractionated dose-escalating donor leukocyte infusion without graft-versus-host disease in a patient with chronic myelogenous leukemia relapsed after allogeneic bone marrow transplantation

    K Inai, Y Wano, S Yamamoto, Y Ikebata, H Iwasaki, H Tsutani, H Naiki, T Ueda

    ANTICANCER RESEARCH   19 ( 6C )   5631 - 5634   1999.11

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MISC

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Presentations

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Awards

  • 平成29年度 日本医師会 医学研究奨励賞

    2017   日本医師会   蛋白結合尿毒症物質に着目した慢性腎臓病関連疾患のメカニズム解明と治療法の開発 ―尿毒症物質の生成減少と除去向上を目指すー

    山本卓

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  • 平成28年度 新潟県医師会 学術奨励賞

    2016   新潟県医師会   尿毒症物質に着目した慢性腎臓病関連疾患の病態解明と治療

    山本卓

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  • 平成28年度 日本腎臓学会 大島賞

    2016   日本腎臓学会   尿毒症物質に着目した慢性腎臓病関連疾患の病態解明と治療

    山本卓

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  • 平成24年度 第16回有壬記念学術奨励賞（基礎医学）

    2012   新潟大学医学部学士会   1. 腎障害で増悪する動脈硬化病変におけるマクロファージアンギオテンシンII受容体の役割 2. 腎障害で増悪する動脈硬化における経口吸着薬AST-120の改善効果

    山本卓

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  • ベストアブストラクト賞

    2012   第57回日本透析医学会学術集会・総会   平成24年：透析患者HDLは動脈硬化病変におけるマクロファージの泡沫細胞化を促進する

    山本卓

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Research Projects

  • ウレミックトキシンによるアルブミン機能異常の解析と恒常性を回復する治療法の開発

    Grant number：24K11427

    2024.4 - 2028.3

    System name：科学研究費助成事業

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    山本 卓, 後藤 祐児, 渡邊 博志, 山口 圭一

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    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

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  • Exploring the supersaturation-dependent protein science

    Grant number：22H02584

    2022.4 - 2026.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）

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  • 新規リン代謝マーカー：ポリリン酸と腎臓病で増悪する感染症の関連

    Grant number：20K08628

    2020.4 - 2024.3

    System name：科学研究費助成事業 基盤研究(C)

    Research category：基盤研究(C)

    Awarding organization：日本学術振興会

    山本 卓

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    Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）

    ポリリン酸が腎臓病患者で増悪する感染症に影響するメカニズムを調査している。免疫細胞とポリリン酸の反応とそれに関わる尿毒症病態について検討した。
    培養細胞マクロファージは少量のリポポリサッカライド(LPS)で炎症性サイトカインの産生を軽微に生じるが、そこにポリリン酸を加えるとその反応が高度に増強された。このポリリン酸の効果は反応させた量と鎖長に依存することが明らかになった。LPSが存在しないとポリリン酸が作用しないため、細胞とLPSの反応におけるポリリン酸の作用点について検討した。その結果、LPSとマクロファージToll-like receptor4との結合をポリリン酸が細胞表面で作用していることが明らかとなった。すなわちポリリン酸はLPSのマクロファージとの反応を細胞表面で促進することで、より炎症反応を増強していることが理解できた。
    腎臓病では多彩なウレミックトキシンが作用し感染症の増悪に寄与している可能性が考えられる。マクロファージにインドキシル硫酸を長期間反応させ、尿毒症状態のマクロファージを作成した。そこにLPSやポリリン酸を反応させるとインドキシル硫酸のない細胞と比較して炎症性サイトカインの発現に違いがみられた。現在、その詳細なメカニズムの解明に取り掛かっている。

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  • The role of abnormal mucosal immunity in renal senescence

    Grant number：19H03674

    2019.4 - 2023.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

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    Grant amount：\17030000 （ Direct Cost: \13100000 、 Indirect Cost：\3930000 ）

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  • 慢性腎臓病患者のtrabecular bone scoreによる臨床的骨質評価

    2018.4

    System name：腎不全病態研究助成

    Awarding organization：(公財)日本腎臓財団

    山本卓

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    Authorship：Principal investigator  Grant type：Competitive

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  • 蛋白結合尿毒素物質のHDL機能への作用と治療―腎臓病による動脈硬化を予防する―

    2015.4 - 2018.3

    System name：平成27年度 基盤研究（C）

    Awarding organization：科学研究費助成事業

    山本卓

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    Authorship：Principal investigator  Grant type：Competitive

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  • Hologenome analysis for elucidation of the pathogenesis and identification of the therapeutic target of IgA nephropathy

    Grant number：26293201

    2014.4 - 2018.3

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

    Narita Ichiei, YAMAMOTO Tadashi, YAMAGUCHI Hiroki, WATANABE Hirohumi, TUCHIDA Masahumi, CHO Takamasa

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    Grant amount：\16250000 （ Direct Cost: \12500000 、 Indirect Cost：\3750000 ）

    To elucidate the etiology of IgA nephropathy, we tried to clarify the functional abnormality and disease process by analyzing simultaneously the host genomics, metagenomics of tonsils, and glomerular proteomics of samples from patients with IgAN. We observed the up-regulation of APRIL and production of galactose-deficient IgA1 (GdIgA1) in the tonsils, which was well correlated with the amount of deposition of GdIgA1 in the glomerulus. The possible involvement of periodontal anaerobic bacilli was suggested by IgA-Seq analysis of tonsils from the patients. The high activity of biosynthesis, TCA cycle, and carbon metabolism, whereas reduced activity of cytoskeleton structure of podocyte, were revealed by glomerular proteomics.
    Genome analyses of both isolated and familial cases indicated that the abnormality in natural innate immunity and antigen presentation may be involved in the initiation of the IgA nephropathy.

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  • 蛋白結合尿毒素物質の除去に関する透析器と血液浄化器の効果検討

    2014.4 - 2015.3

    System name：平成26年度 日本透析医会 研究助成

    Awarding organization：日本透析医会

    山本卓

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    Authorship：Principal investigator  Grant type：Competitive

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  • 経口吸着炭薬による透析患者の蛋白結合尿毒素物質除去と動脈硬化抑制効果

    2014.4 - 2015.3

    System name：第13回循環医学分野一般研究助成

    Awarding organization：先進医薬研究振興財団

    山本卓

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    Authorship：Principal investigator  Grant type：Competitive

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  • 腎臓病で増悪する動脈硬化病変内マクロファージに対する尿毒素分子の関与と治療対策

    2013.4 - 2015.3

    System name：2013年度 医学系研究奨励

    Awarding organization：武田科学振興財団

    山本卓

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    Authorship：Principal investigator  Grant type：Competitive

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  • 腎臓病によって増悪する動脈硬化におけるHDLとマクロファージの機能と治療

    2012.4 - 2014.3

    System name：平成24年度 若手研究(B)

    Awarding organization：科学研究費助成事業

    山本卓

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    Authorship：Principal investigator  Grant type：Competitive

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  • 透析導入に関する予後予測ツールの作成

    2011.4 - 2012.3

    System name：塾生研究助成

    Awarding organization：iHope-協和発酵キリン

    山本卓

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    Authorship：Principal investigator  Grant type：Competitive

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  • 腎臓病で増悪する動脈硬化病変におけるマクロファージの脂質代謝の解明と治療

    2008.4 - 2009.3

    System name：海外留学助成リサーチフェローシップ

    Awarding organization：上原記念生命科学財団

    山本卓

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    Authorship：Principal investigator  Grant type：Competitive

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  • 細胞培養下におけるbeta2-ミクログロブリン関連アミロイド線維形成の機序解明

    2007.4 - 2009.3

    System name：平成19年度 若手研究(B)

    Awarding organization：科学研究費助成事業

    山本卓

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    Authorship：Principal investigator  Grant type：Competitive

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  • Genomics and proteomics analyses ofpathophysiological mechanism in complications associated with long term hemodialysis therapy

    Grant number：19390230

    2007 - 2008

    System name：Grants-in-Aid for Scientific Research

    Research category：Grant-in-Aid for Scientific Research (B)

    Awarding organization：Japan Society for the Promotion of Science

    KAZAMA Junichiro, NARITA Ichiei

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    Grant amount：\14690000 （ Direct Cost: \11300000 、 Indirect Cost：\3390000 ）

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  • 透析アミロイドーシスの研究

    2001 - 2003

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    Grant type：Competitive

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Teaching Experience (researchmap)

  • 腎・膠原病内科学

    Institution name：新潟大学医歯学総合病院

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  • 血液浄化療法

    Institution name：新潟大学医歯学総合病院

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