2025/06/30 更新

写真a

ヤマモト スグル
山本 卓
YAMAMOTO Suguru
所属
教育研究院 医歯学系 医学系列 教授
医歯学総合研究科 腎研究センター 教授
職名
教授
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外部リンク

学位

  • 新潟大学大学院医歯学総合研究科生体機能調節医学 ( 2004年3月   新潟大学 )

研究キーワード

  • CKD-MBD

  • インドキシル硫酸

  • ウレミックトキシン

  • 血液透析

  • 慢性腎臓病

  • アミロイドーシス

研究分野

  • ライフサイエンス / 腎臓内科学

経歴(researchmap)

  • 新潟大学医歯学総合病院   血液浄化療法部   病院教授

    2022年6月 - 現在

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  • 新潟大学   血液浄化療法部   准教授

    2016年7月 - 2022年5月

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  • 新潟大学   腎・膠原病内科   助教

    2015年5月 - 2016年6月

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  • 新潟大学   腎医学医療センター   特任助教

    2011年5月 - 2015年4月

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  • バンダービルト大学   小児科   リサーチフェロー

    2008年5月 - 2011年3月

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  • 福井医科大学   第二病理学教室   大学院生

    2001年7月 - 2003年6月

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  • 新潟大学   第二内科   医員

    2000年4月 - 2001年6月

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  • 新潟大学   Medical and Dental Hospital   研修医

    1998年5月 - 2000年3月

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経歴

  • 新潟大学   教育研究院 医歯学系 医学系列   教授

    2025年1月 - 現在

  • 新潟大学   医歯学総合研究科 腎研究センター   教授

    2025年1月 - 現在

  • 新潟大学   医歯学総合病院 血液浄化療法部   准教授

    2016年7月 - 2024年12月

  • 新潟大学   医歯学総合病院 腎・膠原病内科   助教

    2015年5月 - 2016年6月

  • 新潟大学   医歯学総合研究科   特任助教

    2011年5月 - 2015年4月

学歴

  • 新潟大学   大学院医歯学総合研究科   内部環境医学講座

    2001年4月 - 2004年3月

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  • 新潟大学   医学部   医学科

    1992年4月 - 1998年3月

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所属学協会

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委員歴

  • 日本アミロイドーシス学会   理事  

    2022年10月 - 現在   

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    団体区分:学協会

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  • 日本透析医学会   慢性腎臓病に伴う骨・ミネラル代謝異常の診療ガイドライン改訂ワーキンググループ  

    2022年8月 - 現在   

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  • J-DOPPS   CKD-MBD working group  

    2021年8月 - 現在   

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  • 日本透析医学会   危機管理委員会  

    2021年8月 - 現在   

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  • 日本透析医学会   統計調査委員会  

    2021年8月 - 現在   

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  • 日本透析医学会   専門医制度委員会  

    2021年8月 - 現在   

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  • 日本透析医学会   編集委員会  

    2021年8月 - 2024年7月   

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  • 日本腎臓学会   評議員  

    2020年6月 - 現在   

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  • 日本透析医学会   評議員  

    2020年4月 - 現在   

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  • 日本透析医学会   会員  

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    団体区分:学協会

    日本透析医学会

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  • 日本腎臓学会   会員  

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    団体区分:学協会

    日本腎臓学会

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  • 日本内科学会   会員  

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    団体区分:学協会

    日本内科学会

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論文

  • Appropriate Anthropometric Indices for Geriatric Nutritional Risk Index in Predicting Mortality in Older Japanese Patients: A Comparison of the Lorentz Formula and Body Mass Index. 査読

    Kou Kitabayashi, Suguru Yamamoto, Ichiei Narita

    The Tohoku journal of experimental medicine   2024年1月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1620/tjem.2024.J001

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  • Alkaline Phosphatase and Parathyroid Hormone Levels: International Variation and Associations With Clinical Outcomes in the DOPPS 査読

    Suguru Yamamoto

    Kidney International Reports   2024年1月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/J.EKIR.2024.01.002

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  • Pruritus and protein-bound uremic toxins in patients undergoing hemodialysis: a cross-sectional study. 国際誌

    Suguru Yamamoto, Takahiro Tanaka, Kentaro Omori, Isei Ei, Kaori Kikuchi, Ayano Konagai, Shin Goto, Nobutaka Kitamura, Ichiei Narita

    Clinical kidney journal   17 ( 1 )   sfae007   2024年1月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Patients undergoing hemodialysis frequently experience pruritus; its severity is associated with poor quality of life and mortality. Recent progress in hemodialysis treatment has improved the removal of small- and middle-molecular-weight molecules; however, the removal of protein-bound uremic toxins (PBUTs) remains difficult. It is possible that pruritus is associated with serum PBUTs in patients undergoing hemodialysis. METHODS: We conducted a multicenter cross-sectional study in patients undergoing hemodialysis (n = 135). The severity of pruritus was assessed using the 5D-itch scale and medication use. Serum PBUTs, including indoxyl sulfate, p-cresyl sulfate, indole acetic acid, phenyl sulfate, and hippuric acid, were measured using mass spectrometry; the PBUT score was calculated from these toxins using principal component analysis. Univariate and multiple regression analyses were performed to examine independent predictors of pruritus. RESULTS: Pruritus was reported by 62.2%, 21.5%, and 13.3%, 1.5% and 0.7% as 5 (not at all), 6-10, 11-15, 16-20, and 21-25 points, respectively. The PBUT score was higher in patients undergoing dialysis having pruritus than those without pruritus (0.201 [-0.021 to 0.424] vs -0.120 [-0.326 to 0.087]; P = 0.046). The PBUT score was shown to have an association with the presence of pruritus (coefficient 0.498[Formula: see text]0.225, odds ratio: 1.65 [1.06-2.56]; P = 0.027). CONCLUSION: Uremic pruritus was frequently found and associated with the PBUT score in patients undergoing hemodialysis. Further studies are required to clarify the impact of PBUTs on uremic pruritus and to explore therapeutic strategies in patients undergoing hemodialysis.

    DOI: 10.1093/ckj/sfae007

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  • Removal of α1-Microglobulin Using Post-Dilution Online Hemodiafiltration with Polymethylmethacrylate Membrane: An Open-Label, Single-Arm Study. 査読 国際誌

    Shiori Yoshida, Suguru Yamamoto, Daisuke Miyauchi, Ryohei Terashima, Atsushi Hashimoto, Haruna Miyazawa, Takahiro Tanaka, Masahiro Ishizawa, Mototsugu Tanaka, Yoshihiko Tomita, Ikuo Aoike, Shin Goto, Ichiei Narita

    Blood purification   1 - 7   2023年11月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: The removal of low- and medium-molecular-weight proteins has been improved with online hemodiafiltration (OL-HDF) and hemodialysis using high-flux membranes; however, the outcomes of patients with end-stage kidney disease (ESKD) undergoing dialysis treatment are still worse than in the general population. α1-Microglobulin (α1-m), with a molecular weight of 33,000 Da, may contribute to dialysis-related disorders and mortality. However, the removal is insufficient even with current OL-HDF using the polysulfone (PS) membrane, which is common in Japan. Polymethylmethacrylate (PMMA) membranes can remove medium- to high-molecular-weight proteins by adsorption. This study aimed to assess the efficacy of removing medium- to high-molecular-weight proteins, such as α1-m and β2-microglobulin (β2-m), through post-dilution OL-HDF with PMMA (Post-PMMA). The assessment was conducted in comparison to pre-dilution OL-HDF with PS (Pre-PS), using an open-label, single-arm study. METHODS: Seven patients with ESKD on Pre-PS underwent Post-PMMA with replacement volume of 30 mL/min (low flow) and 50 mL/min (high flow). Clearance and removal rates of α1-m, β2-m, small molecules, inflammatory cytokines, and albumin were measured at 60 and 240 min of treatment. RESULTS: Clearance rates of α1-m at 60 min were -2.8 ± 5.2 mL/min with Pre-PS, -0.4 ± 2.6 mL/min with Post-PMMA (low), and 0.6 ± 3.4 mL/min with Post-PMMA (high). The removal rate of α1-m was higher in Post-PMMA than that in Pre-HDF-PS (Post-PMMA [high] 17.7 ± 5.9%, Post-PMMA [low] 15.0 ± 5.6%, and Pre-PS 4.1 ± 5.5%). Adsorption clearance of β2-m was increased with Post-PMMA. Albumin leakage in Post-PMMA was not higher than that in Pre-PS. CONCLUSION: The removal rate of α1-m with Post-PMMA was higher than that with Pre-PS. The PMMA membrane adsorbed β2-m, suggesting the removal effect of medium- to high-molecular-weight proteins by the adsorption method. Since Post-PMMA effectively removes α1-m without excessive albumin leakage, it will be useful for patients with ESKD, especially those with a poor nutritional status.

    DOI: 10.1159/000534459

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  • Low muscle strength and physical function contribute to falls in hemodialysis patients, but not muscle mass 査読

    Shirai N, Yamamoto S, Osawa Y, Tsubaki A, Morishita S, Sugahara T, Narita I

    Clin Exp Nephrol   in press   2023年

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: Patients on hemodialysis (HD) have a higher incidence of fractures than the general population. Sarcopenia is frequently observed in patients on HD; however, the association of falls with sarcopenia and its diagnostic factors, including muscle mass, muscle strength, and physical function, are incompletely understood. METHODS: This prospective cohort study was conducted at a single center. Sarcopenia was assessed according to the 2019 Asian Working Group for Sarcopenia diagnostic criteria. Muscle mass was measured the bioelectrical impedance method. Grip strength was evaluated to assess muscle strength, while the Short Physical Performance Battery (SPPB) was used to assess physical function. Falls and their detailed information were surveyed every other week. RESULTS: This study analyzed 65 HD patients (median age, 74.5 [67.5-80.0] years; 33 women [49.2%]). Sarcopenia was diagnosed in 36 (55.4%) patients. During the 1-year observation period, 31 (47.7%) patients experienced accidental falls. The falls group had lower median grip strength than the non-falls group (14.7 [11.4-21.8] kg vs. 22.2 [17.9-27.6] kg; p < 0.001). The median SPPB score was also lower in the falls versus non-falls group (7.0 [5.0-11.0] vs. 11.0 [8.0-12.0]; p = 0.009). In adjusted multiple regression analysis, diagnostic factors, including grip strength (B = 0.96, p = 0.04, R2 = 0.19) and SPPB (B = 1.11, p = 0.006, R2 = 0.23), but not muscle mass, were independently associated with fall frequency. CONCLUSIONS: The frequency of falls in HD patients was related to muscle strength and physical function, but not muscle mass.

    DOI: 10.1007/s10157-023-02403-4

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  • プロテオーム解析 招待

    羽深将人, 山本 卓, 内木宏延, 山本 格, 成田一衛

    64 ( 8 )   863 - 867   2022年12月

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    担当区分:責任著者  

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  • Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis 査読 国際誌

    Kichitaro Nakajima, Keiichi Yamaguchi, Masahiro Noji, César Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Lianjie Zhou, Hirotsugu Ogi, Toru Ito, Ichiei Narita, Fumitake Gejyo, Hironobu Naiki, Suguru Yamamoto, Yuji Goto

    Nature communications   13 ( 1 )   5689 - 5689   2022年10月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Cold Spring Harbor Laboratory  

    Abstract

    Dialysis-related amyloidosis (DRA), a serious complication among long-term hemodialysis patients, is caused by amyloid fibrils of β<sub>2</sub>-microglobulin (β2m). Although high serum β2m levels and a long dialysis vintage are the primary and secondary risk factors for the onset of DRA, respectively, patients with these do not always develop DRA, indicating that there are additional risk factors. To clarify these unknown factors, we investigated the effects of human sera on β2m amyloid fibril formation. Although sera markedly inhibited amyloid fibril formation, the inhibitory effects were weaker for sera collected from dialysis patients than for control sera. When sera collected before and after maintenance dialysis treatments were compared, the latter inhibited amyloid fibril formation more than the former. These results indicate that, although the inhibitory effects of sera were deteriorated in long-term dialysis patients, they were ameliorated by maintenance dialysis treatments in the short term. Maintenance dialysis decreases the body weight by 5% and consequently increases the concentrations of serum components. Among these components, we found that serum albumin prevented amyloid fibril formation based on macromolecular crowding effects, and that the decreased serum albumin concentration in dialysis patients is a tertiary risk factor for the onset of DRA. The model was constructed assuming accumulative effects of three risk factors and may be useful for predicting the onset of DRA. Furthermore, the model suggested the importance of monitoring temporary and accumulated risks to prevent the development of amyloidoses in general, which occurs based on supersaturation-limited amyloid fibril formation in a crowded milieu.

    DOI: 10.1101/2022.02.01.478730

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  • Dynamic and static balance functions in hemodialysis patients and non-dialysis dependent CKD patients. 査読 国際誌

    Nobuyuki Shirai, Suguru Yamamoto, Yutaka Osawa, Atsuhiro Tsubaki, Shinichiro Morishita, Ichiei Narita

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy   2022年9月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: Chronic kidney disease (CKD) patients undergoing hemodialysis (HD) have a high risk of falls, whereas the impairment in balance function and their types in HD compared with non-dialysis dependent (ND) CKD have not been fully evaluated. METHODS: We conducted a cross-sectional study to assess the balance function in 91 ND-CKD and 65 HD patients. The participants underwent the timed up-and-go test (TUG) to assess dynamic balance and length of the center of pressure (CoP) with open eyes or closed eyes to evaluate static balance. RESULTS: TUG, length of CoP with open eyes, and length of CoP with closed eyes were longer in HD patients compared with those with ND-CKD. Multiple regression analysis showed that dialysis treatment independently affected TUG and length of CoP with open eyes. CONCLUSION: The dynamic and static balance functions are impaired in HD patients compared with that ND-CKD patients. This article is protected by copyright. All rights reserved.

    DOI: 10.1111/1744-9987.13931

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  • Association of the nutritional risk index for Japanese hemodialysis with mortality and dietary nutritional intake in patients undergoing hemodialysis during long-term hospitalization. 査読

    26 ( 12 )   1200 - 1207   2022年8月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10157-022-02259-0

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  • Relationship between Nutrition-Related Problems and Falls in Hemodialysis Patients: A Narrative Review 査読 国際誌

    Nobuyuki Shirai, Tatsuro Inoue, Masato Ogawa, Masatsugu Okamura, Shinichiro Morishita, Yamamoto Suguru, Atsuhiro Tsubaki

    Nutrients   14 ( 15 )   3225 - 3225   2022年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI AG  

    Falls are a social problem that increase healthcare costs. Hemodialysis (HD) patients need to avoid falling because fractures increase their risk of death. Nutritional problems such as frailty, sarcopenia, undernutrition, protein-energy wasting (PEW), and cachexia may increase the risk of falls and fractures in patients with HD. This review aimed to summarize the impact of frailty, sarcopenia, undernutrition, PEW, and cachexia on falls in HD patients. The reported global incidence of falls in HD patients is 0.85–1.60 falls per patient per year. HD patients fall frequently, but few reports have investigated the relationship between nutrition-related problems and falls. Several studies reported that frailty and undernutrition increase the risk of falls in HD patients. Nutritional therapy may help to prevent falls in HD patients. HD patients’ falls are caused by nutritional problems such as iatrogenic and non-iatrogenic factors. Falls increase a person’s fear of falling, reducing physical activity, which then causes muscle weakness and further decreased physical activity; this cycle can cause multiple falls. Further research is necessary to clarify the relationships between falls and sarcopenia, cachexia, and PEW. Routine clinical assessments of nutrition-related problems are crucial to prevent falls in HD patients.

    DOI: 10.3390/nu14153225

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  • Dysfunction in dynamic, but not static balance is associated with risk of accidental falls in hemodialysis patients: a prospective cohort study 査読 国際誌

    BMC Nephrology   23 ( 1 )   237 - 237   2022年7月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s12882-022-02877-6

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  • Medical Director Practice of Advising Increased Dietary Protein Intake in Hemodialysis Patients With Hyperphosphatemia: Associations With Mortality in the Dialysis Outcomes and Practice Patterns Study 査読 国際誌

    Suguru Yamamoto, Brian A. Bieber, Hirotaka Komaba, Norio Hanafusa, Hiroki Kitabayashi, Takanobu Nomura, Aleix Cases, Christian Combe, Ronald L. Pisoni, Bruce M. Robinson, Masafumi Fukagawa

    Journal of Renal Nutrition   32 ( 2 )   243 - 250   2022年2月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    OBJECTIVES: Patients undergoing hemodialysis (HD) may have poor nutritional status and hyperphosphatemia. Nephrologists sometimes manage hyperphosphatemia by prescribing phosphate binders and/or recommending restriction of dietary phosphate including protein-rich foods; the later may, however, adversely affect nutritional status. DESIGN AND METHODS: The analysis includes 8805 HD patients on dialysis ≥ 120 days in 12 countries in Dialysis Outcomes and Practice Patterns Study (DOPPS) phase 4 (2009-2011), from 248 facilities. The primary exposure variable was response to the following question: "For patients with serum albumin 3.0 g/dL and phosphate 6.0 mg/dL, do you recommend to (A) increase or (B) decrease/no change in dietary protein intake (DPI)?". The association between medical director's practice of recommending an increase in DPI and all-cause mortality was analyzed with Cox regression adjusted for potential confounders. Linear and logistic regressions were used to model the cross-sectional associations between DPI advice practice and intermediate markers of patient nutrition. RESULTS: Median follow-up was 1.6 years. In the case scenario, 91% of medical directors in North America had a practice of recommending DPI increase compared to 58% in Europe (range = 36%-83% across 7 countries) and 56% in Japan. The practice of advising DPI increase was weakly associated with lower mortality [HR (95% CI): 0.88 (0.76-1.02)]. The association tended to be stronger in patients with age 70+ years [HR (95% CI): 0.82 (0.69-0.97), P = .12 for interaction]. The practice of advising DPI increase was associated with 0.276 mg/dL higher serum creatinine levels (95% CI: 0.033-0.520) after adjustment for case mix. CONCLUSIONS: Medical director's practice of recommending an increase in DPI for HD patients with low albumin and high phosphate levels was associated with higher serum creatinine levels and potentially lower all-cause mortality. To recommend protein intake liberalization in parallel with phosphate management by physicians may be a critical practice for better nutritional status and outcomes in HD patients.

    DOI: 10.1053/j.jrn.2021.02.007

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  • Magnesium intake by enteral formulation affects serum magnesium concentration in patients undergoing hemodialysis. 査読 国際誌

    Kou Kitabayashi, Suguru Yamamoto, Ichiei Narita

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy   26 ( 4 )   749 - 755   2021年11月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Decreased serum magnesium levels are associated with mortality and fractures in patients with chronic kidney disease; however, there is no recommendation for Mg intake in these populations. This study used cross-sectional analysis to examine the association between Mg intake and serum Mg levels in patients undergoing hemodialysis. Sixty-one patients were included. The daily Mg intake was 185 mg (IQR: 151-203 mg), and serum Mg level was 2.4 mg/dL (IQR: 2.2-2.7 mg/dL). Multiple regression analysis showed that intake of enteral formulation by tube feeding was an independent factor associated with serum Mg level (B = 0.90 [95% confidence interval: 0.61-1.20], p < 0.01). These findings may aid in serum Mg level management through diet and enteral formulation in patients undergoing hemodialysis.

    DOI: 10.1111/1744-9987.13760

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  • Fear of falling and physical activity in hemodialysis patients: a pilot study 査読

    Suguru Yamamoto

    Renal Replacement Therapy   7   63   2021年11月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/S41100-021-00383-3

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  • Comparison of muscle strength between hemodialysis patients and non-dialysis patients with chronic kidney disease. 査読

    Nobuyuki Shirai, Suguru Yamamoto, Yutaka Osawa, Atsuhiro Tsubaki, Shinichiro Morishita, Kanami Igarashi, Ichiei Narita

    Journal of physical therapy science   33 ( 10 )   742 - 747   2021年10月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    [Purpose] Muscle weakness in patients with chronic kidney disease is associated with several disease-related factors, and this study aimed to examine whether hemodialysis is one of risk factors for muscle weakness in patients with chronic kidney disease. [Participants and Methods] We conducted a cross-sectional study with 74 non-dialysis and 84 hemodialysis patients. Muscle strength evaluations were performed by measuring isometric knee extensor muscle strength and grip strength. Each evaluation item was compared between the hemodialysis and non-dialysis groups, and multiple regression analysis was performed to determine the factors associated with muscle strength. In addition, the correlation between lower-extremity muscle strength and grip strength was examined in each group. [Results] Isometric knee extensor muscle strength was significantly lower in the hemodialysis group than in the non-dialysis group. Grip strength was also significantly lower in the hemodialysis group than in the non-dialysis group. Hemodialysis was determined to be an independent risk factor associated with lower limb muscle strength as well as grip strength. The positive correlation between isometric knee extensor muscle strength and grip strength was almost the same in the groups. [Conclusion] Hemodialysis treatment was an independent risk factor for muscle weakness. Regular monitoring of grip strength may facilitate better management with physical therapy in hemodialysis patients.

    DOI: 10.1589/jpts.33.742

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  • Locomotive syndrome in hemodialysis patients and its association with quality of life-a cross-sectional study 査読

    Suguru Yamamoto

    Renal Replacement Therapy   7   36   2021年6月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/S41100-021-00352-W

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  • Serum total indoxyl sulfate and clinical outcomes in hemodialysis patients: results from the Japan Dialysis Outcomes and Practice Patterns Study 査読 国際誌

    Suguru Yamamoto, Douglas S Fuller, Hirotaka Komaba, Takanobu Nomura, Ziad A Massy, Brian Bieber, Bruce Robinson, Ronald Pisoni, Masafumi Fukagawa

    Clinical Kidney Journal   14 ( 4 )   1236 - 1243   2021年4月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    <title>Abstract</title>
    <sec>
    <title>Background</title>
    Uremic toxins are associated with various chronic kidney disease-related comorbidities. Indoxyl sulfate (IS), a protein-bound uremic toxin, reacts with vasculature, accelerating atherosclerosis and/or vascular calcification in animal models. Few studies have examined the relationship of IS with clinical outcomes in a large cohort of hemodialysis (HD) patients.


    </sec>
    <sec>
    <title>Methods</title>
    We included 1170 HD patients from the Japan Dialysis Outcomes and Practice Patterns Study Phase 5 (2012–15). We evaluated the associations of serum total IS (tIS) levels with all-cause mortality and clinical outcomes including cardiovascular (CV)-, infectious- and malignancy-caused events using Cox regressions.


    </sec>
    <sec>
    <title>Results</title>
    The median (interquartile range) serum tIS level at baseline was 31.6 μg/mL (22.6–42.0). Serum tIS level was positively associated with dialysis vintage. Median follow-up was 2.8 years (range: 0.01–2.9). We observed 174 deaths (14.9%; crude rate, 0.06/year). Serum tIS level was positively associated with all-cause mortality [adjusted hazard ratio per 10 μg/mL higher, 1.16; 95% confidence interval (CI) 1.04–1.28]. Association with cause-specific death or hospitalization events, per 10 μg/mL higher serum tIS level, was 1.18 (95% CI 1.04–1.34) for infectious events, 1.08 (95% CI 0.97–1.20) for CV events and 1.02 (95% CI 0.87–1.21) for malignancy events after adjusting for covariates including several nutritional markers.


    </sec>
    <sec>
    <title>Conclusions</title>
    In a large cohort study of HD patients, serum tIS level was positively associated with all-cause mortality and infectious events.


    </sec>

    DOI: 10.1093/ckj/sfaa121

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  • pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro 査読 国際誌

    Suguru Yamamoto, Kenichi Sasahara, Mio Domon, Keiichi Yamaguchi, Toru Ito, Shin Goto, Yuji Goto, Ichiei Narita

    Toxins   13 ( 2 )   116 - 116   2021年2月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI AG  

    Protein-bound uremic toxins (PBUTs) are difficult to remove using conventional dialysis treatment owing to their high protein-binding affinity. As pH changes the conformation of proteins, it may be associated with the binding of uremic toxins. Albumin conformation at pH 2 to 13 was analyzed using circular dichroism. The protein binding behavior between indoxyl sulfate (IS) and albumin was examined using isothermal titration calorimetry. Albumin with IS, and serum with IS, p-cresyl sulfate, indole acetic acid or phenyl sulfate, as well as serum from hemodialysis patients, were adjusted pH of 3 to 11, and the concentration of the free PBUTs was measured using mass spectrometry. Albumin was unfolded at pH &lt; 4 or &gt;12, and weakened interaction with IS occurred at pH &lt; 5 or &gt;10. The concentration of free IS in the albumin solution was increased at pH 4.0 and pH 11.0. Addition of human serum to each toxin resulted in increased free forms at acidic and alkaline pH. The pH values of serums from patients undergoing hemodialysis adjusted to 3.4 and 11.3 resulted in increased concentrations of the free forms of PBUTs. In conclusion, acidic and alkaline pH conditions changed the albumin conformation and weakened the protein binding property of PBUTs in vitro.

    DOI: 10.3390/toxins13020116

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  • Inorganic polyphosphate potentiates lipopolysaccharide-induced macrophage inflammatory response. 査読 国際誌

    Toru Ito, Suguru Yamamoto, Keiichi Yamaguchi, Mami Sato, Yoshikatsu Kaneko, Shin Goto, Yuji Goto, Ichiei Narita

    The Journal of biological chemistry   295 ( 12 )   4014 - 4023   2020年3月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Inorganic polyphosphate (polyP) is a linear polymer of orthophosphate units that are linked by phosphoanhydride bonds and is involved in various pathophysiological processes. However, the role of polyP in immune cell dysfunction is not well-understood. In this study, using several biochemical and cell biology approaches, including cytokine assays, immunofluorescence microscopy, receptor-binding assays with quartz crystal microbalance, and dynamic light scanning, we investigated the effect of polyP on in vitro lipopolysaccharide (LPS)-induced macrophage inflammatory response. PolyP up-regulated LPS-induced production of the inflammatory cytokines, such as tumor necrosis factor α, interleukin-1β, and interleukin-6, in macrophages, and the effect was polyP dose- and chain length-dependent. However, orthophosphate did not exhibit this effect. PolyP enhanced the LPS-induced intracellular macrophage inflammatory signals. Affinity analysis revealed that polyP interacts with LPS, inducing formation of small micelles, and the polyP-LPS complex enhanced the binding affinity of LPS to Toll-like receptor 4 (TLR4) on macrophages. These results suggest that inorganic polyP plays a critical role in promoting inflammatory response by enhancing the interaction between LPS and TLR4 in macrophages.

    DOI: 10.1074/jbc.RA119.011763

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  • Adsorption of Protein-Bound Uremic Toxins Using Activated Carbon through Direct Hemoperfusion in vitro 査読

    Suguru Yamamoto, Toru Ito, Mami Sato, Shin Goto, Junichiro J. Kazama, Fumitake Gejyo, Ichiei Narita

    Blood Purification   48 ( 3 )   215 - 222   2019年

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:S. Karger AG  

    DOI: 10.1159/000500014

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  • Mineral and bone disorder management in hemodialysis patients: comparing PTH control practices in Japan with Europe and North America: the Dialysis Outcomes and Practice Patterns Study (DOPPS) 査読

    Yamamoto Suguru, Karaboyas Angelo, Komaba Hirotaka, Taniguchi Masatomo, Nomura Takanobu, Bieber Brian A, De Sequera Patricia, Christensson Anders, Pisoni Ronald L, Robinson Bruce M, Fukagawa Masafumi

    BMC NEPHROLOGY   19 ( 1 )   2018年10月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s12882-018-1056-5

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  • Molecular mechanisms underlying uremic toxin-related systemic disorders in chronic kidney disease: focused on β<sub>2</sub>-microglobulin-related amyloidosis and indoxyl sulfate-induced atherosclerosis-Oshima Award Address 2016. 査読

    Yamamoto S

    Clinical and experimental nephrology   23 ( 2 )   1 - 7   2018年6月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10157-018-1588-9

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  • Indoxyl Sulfate Promotes Macrophage IL-1β Production by Activating Aryl Hydrocarbon Receptor/NF-κ/MAPK Cascades, but the NLRP3 inflammasome Was Not Activated. 査読

    Wakamatsu T, Yamamoto S, Ito T, Sato Y, Matsuo K, Takahashi Y, Kaneko Y, Goto S, Kazama JJ, Gejyo F, Narita I

    Toxins   10 ( 3 )   2018年3月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/toxins10030124

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  • Adsorption of Protein-Bound Uremic Toxins Through Direct Hemoperfusion With Hexadecyl-Immobilized Cellulose Beads in Patients Undergoing Hemodialysis 査読

    Suguru Yamamoto, Mami Sato, Yoko Sato, Takuya Wakamatsu, Yoshimitsu Takahashi, Akira Iguchi, Kentaro Omori, Yasushi Suzuki, Isei Ei, Yoshikatsu Kaneko, Shin Goto, Junichiro J. Kazama, Fumitake Gejyo, Ichiei Narita

    Artificial Organs   42 ( 1 )   88 - 93   2018年1月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/aor.12961

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  • Uremic Toxicity and Bone in CKD 査読

    Suguru Yamamoto, Masafumi Fukagawa

    JOURNAL OF NEPHROLOGY   30 ( 5 )   623 - 627   2017年10月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s40620-017-0406-x

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  • Direct hemoperfusion with β<inf>2</inf>-microglobulin adsorption column for patients with end-stage kidney disease

    Suguru Yamamoto, Junichro J. Kazama

    Hemoperfusion, Plasmaperfusion and Other Clinical Uses of General, Biospecific, Immuno and Leucocyte Adsorbents   4   285 - 296   2017年4月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:論文集(書籍)内論文  

    DOI: 10.1142/9919

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  • Hemodiafiltration for hepatic encephalopathy induced by Budd-Chiari syndrome in a patient with end-stage kidney disease. 査読

    Wakamatsu T, Yamamoto S, Kamimura K, Nakatsue T, Iino N, Iguchi S, Kaneko Y, Goto S, Kazama JJ, Narita I

    CEN case reports   5 ( 2 )   125 - 130   2016年11月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s13730-015-0209-7

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  • The macrophage and its related cholesterol efflux as a HDL function index in atherosclerosis 査読

    Suguru Yamamoto, Ichiei Narita, Kazuhiko Kotani

    CLINICA CHIMICA ACTA   457   117 - 122   2016年6月

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    担当区分:筆頭著者, 責任著者   記述言語:英語  

    DOI: 10.1016/j.cca.2016.04.012

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  • Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype 査読

    Suguru Yamamoto, Jiayong Zhong, Patricia G. Yancey, Yiqin Zuo, MacRae F. Linton, Sergio Fazio, Haichun Yang, Ichiei Narita, Valentina Kon

    ATHEROSCLEROSIS   242 ( 1 )   56 - 64   2015年9月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.atherosclerosis.2015.06.055

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  • Continuous Reduction of Protein-Bound Uraemic Toxins with Improved Oxidative Stress by Using the Oral Charcoal Adsorbent AST-120 in Haemodialysis Patients 査読

    Suguru Yamamoto, Junichiro J. Kazama, Kentaro Omori, Koji Matsuo, Yoshimitsu Takahashi, Kazuko Kawamura, Takayuki Matsuto, Hiroshi Watanabe, Toru Maruyama, Ichiei Narita

    SCIENTIFIC REPORTS   5   14381   2015年9月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/srep14381

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  • Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate 査読

    Koji Matsuo, Suguru Yamamoto, Takuya Wakamatsu, Yoshimitsu Takahashi, Kazuko Kawamura, Yoshikatsu Kaneko, Shin Goto, Junichiro J. Kazama, Ichiei Narita

    TOXINS   7 ( 8 )   3155 - 3166   2015年8月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/toxins7083155

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  • Risk Score to Predict 1-Year Mortality after Haemodialysis Initiation in Patients with Stage 5 Chronic Kidney Disease under Predialysis Nephrology Care 査読

    Toshiki Doi, Suguru Yamamoto, Takatoshi Morinaga, Ken-ei Sada, Noriaki Kurita, Yoshihiro Onishi

    PLOS ONE   10 ( 6 )   e0129180   2015年6月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1371/journal.pone.0129180

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  • Use of Renin-Angiotensin System Inhibitors Is Associated with Reduction of Fracture Risk in Hemodialysis Patients 査読

    Suguru Yamamoto, Ryo Kido, Yoshihiro Onishi, Shingo Fukuma, Tadao Akizawa, Masafumi Fukagawa, Junichiro J. Kazama, Ichiei Narita, Shunichi Fukuhara

    PLOS ONE   10 ( 4 )   e0122691   2015年4月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1371/journal.pone.0122691

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  • Chronic kidney disease induced dysfunction of high density lipoprotein 査読

    Suguru Yamamoto, Valentina Kon

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   18 ( 2 )   251 - 254   2014年4月

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    担当区分:筆頭著者   記述言語:英語  

    DOI: 10.1007/s10157-013-0857-x

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  • Autophagy: a two-edged sword in diabetes mellitus. 査読

    Yamamoto S, Kazama JJ, Fukagawa M

    The Biochemical journal   456 ( 3 )   e1 - 3   2013年12月

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    担当区分:筆頭著者  

    DOI: 10.1042/BJ20131282

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  • Dysfunctional High-Density Lipoprotein in Patients on Chronic Hemodialysis 査読

    Suguru Yamamoto, Patricia G. Yancey, Alp Ikizler, W. Gray Jerome, Ryohei Kaseda, Brian Cox, Aihua Bian, Ayumi Shintani, Agnes B. Fogo, MacRae F. Linton, Sergio Fazio, Valentina Kon

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   60 ( 23 )   2372 - 2379   2012年12月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jacc.2012.09.013

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  • β2-Microglobulin 査読

    Suguru Yamamoto, Junichiro James Kazama, Hiroki Maruyama, Ichiei Narita, Fumitake Gejyo

    Uremic Toxins   249 - 258   2012年9月

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    担当区分:筆頭著者, 責任著者   記述言語:英語   掲載種別:論文集(書籍)内論文   出版者・発行元:John Wiley and Sons  

    DOI: 10.1002/9781118424032.ch16

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  • Macrophage Polarization by Angiotensin II-Type 1 Receptor Aggravates Renal Injury-Acceleration of Atherosclerosis 査読

    Suguru Yamamoto, Patricia G. Yancey, Yiqin Zuo, Li-Jun Ma, Ryohei Kaseda, Agnes B. Fogo, Iekuni Ichikawa, MacRae F. Linton, Sergio Fazio, Valentina Kon

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   31 ( 12 )   2856 - U277   2011年12月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1161/ATVBAHA.111.237198

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  • Oral activated charcoal adsorbent (AST-120) ameliorates extent and instability of atherosclerosis accelerated by kidney disease in apolipoprotein E-deficient mice 査読

    Suguru Yamamoto, Yiqin Zuo, Ji Ma, Patricia G. Yancey, Tracy E. Hunley, Masaru Motojima, Agnes B. Fogo, MacRae F. Linton, Sergio Fazio, Iekuni Ichikawa, Valentina Kon

    NEPHROLOGY DIALYSIS TRANSPLANTATION   26 ( 8 )   2491 - 2497   2011年8月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/ndt/gfq759

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  • Recent progress in understanding dialysis-related amyloidosis 査読

    Suguru Yamamoto, Junichiro James Kazama, Ichiei Narita, Hironobu Naiki, Fumitake Gejyo

    BONE   45   S39 - S42   2009年7月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bone.2009.03.655

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  • Mechanisms for increased cardiovascular disease in chronic kidney dysfunction 査読

    Suguru Yamamoto, Valentina Kon

    CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION   18 ( 3 )   181 - 188   2009年5月

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    担当区分:筆頭著者   記述言語:英語  

    DOI: 10.1097/MNH.0b013e328327b360

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  • Patients undergoing dialysis therapy for 30 years or more survive with serious osteoarticular disorders 査読

    S. Yamamoto, J. J. Kazama, H. Maruyama, S. Nishi, I. Narita, F. Gejyo

    CLINICAL NEPHROLOGY   70 ( 6 )   496 - 502   2008年12月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Historical background and clinical treatment of dialysis-related amyloidosis. 査読

    Yamamoto S, Gejyo F

    Biochimica et biophysica acta   1753 ( 1 )   4 - 10   2005年11月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bbapap.2005.09.006

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  • Kinetic analysis of the polymerization and depolymerization of beta(2)-microglobulin-related amyloid fibrils in vitro. 査読

    Yamamoto S, Hasegawa K, Yamaguchi I, Goto Y, Gejyo F, Naiki H

    Biochimica et biophysica acta   1753 ( 1 )   34 - 43   2005年11月

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    担当区分:筆頭著者  

    DOI: 10.1016/j.bbapap.2005.07.007

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  • Low concentrations of sodium dodecyl sulfate induce the extension of beta(2)-microglobulin-related amyloid fibrils at a neutral pH 査読

    S Yamamoto, K Hasegawa, Yamaguchi, I, S Tsutsumi, J Kardos, Y Goto, F Gejyo, H Naiki

    BIOCHEMISTRY   43 ( 34 )   11075 - 11082   2004年8月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Glycosaminoglycans enhance the trifluoroethanol-induced extensionof beta(2)-microglobulin-related amyloid fibrils at a neutral pH 査読

    S Yamamoto, Yamaguchi, I, K Hasegawa, S Tsutsumi, Y Goto, F Gejyo, H Naiki

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   15 ( 1 )   126 - 133   2004年1月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/01.ASN.0000103228.81623.C7

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  • High peritoneal clearance of small molecules did not provide low serum beta(2)-microglobulin concentrations in peritoneal dialysis patients 査読

    S Yamamoto, A Kasai, H Shimada

    PERITONEAL DIALYSIS INTERNATIONAL   23   S34 - S36   2003年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Impact of Dialysis Duration and Frailty on Frailty Progression: A Japanese Nationwide Cohort Study

    Kakuya Niihata, Noriaki Kurita, Ryohei Inanaga, Tatsunori Toida, Masanori Abe, Takao Masaki, Suguru Yamamoto

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  • An end-stage kidney disease patient undergoing dialysis treatment for 50 years with dialysis-related amyloidosis in multiple organs

    Toru Ito, Takashi Kato, Suguru Yamamoto, Hisaki Shimada, Hideyuki Kabasawa, Shin Goto, Riuko Ohashi, Ichiei Narita

    CEN Case Reports   2025年6月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s13730-025-01003-3

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  • Genetic and protein structure prediction analyses identify a rare pathogenic PKD1 variant causing autosomal dominant polycystic kidney disease.

    Takamitsu Shiiya, Hirofumi Watanabe, Ryo Aida, Tadashi Otsuka, Ryohei Kaseda, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Ichiei Narita

    CEN case reports   2025年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenic kidney disorders. The diagnosis of ADPKD requires imaging findings showing multiple kidney cysts or genetic testing, in cases where a family history is unknown. We report a patient diagnosed with ADPKD based on the identification of a rare PKD1 variant. The patient was a 41-year-old female in whom cysts and calcification in the kidneys were incidentally detected. Whole-exome sequencing identified a rare PKD1 variant (NM_001009944.3: c.11557G > A/p.E3853K). Protein structure prediction of the PKD1-PKD2 complex showed that the variant may be pathogenic, leading to the diagnosis of autosomal dominant polycystic kidney disease. A detailed family history revealed that her relatives also had ADPKD, further supporting the diagnosis of ADPKD. Comprehensive genetic analysis and protein structure prediction led to the diagnosis of ADPKD and the identification of rare causative genes. These methods are useful for diagnosing hereditary kidney diseases of unknown etiologies.

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  • Peristaltic pump-triggered amyloid formation suggests shear stresses are in vivo risks for amyloid nucleation

    Yuji Goto, Tomoki Ota, Wenlou Yuan, Ikuko Yumen, Keiichi Yamaguchi, Hirokazu Matsuda, Suguru Yamamoto, Hirotsugu Ogi

    npj Biosensing   2 ( 1 )   2025年1月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1038/s44328-025-00027-0

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    その他リンク: https://www.nature.com/articles/s44328-025-00027-0

  • Nutritional changes in patients undergoing hemodialysis who develop COVID-19

    Kou Kitabayashi, Suguru Yamamoto, Shin Goto

    Renal Replacement Therapy   2025年1月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s41100-024-00600-9

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  • Response to Letter to the Editor: Is the “Nutritional Risk Index for Japanese Hemodialysis” Validated as a Nutritional and Prognostic Indicator?

    Katsuhito Mori, Yosuke Yamamoto, Norio Hanafusa, Suguru Yamamoto, Shingo Fukuma, Yoshihiro Onishi, Masanori Emoto, Masaaki Inaba

    Journal of Renal Nutrition   2025年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1053/j.jrn.2024.12.004

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  • Systemic AA amyloidosis with amyloid deposition in the peritoneum at the time of initiating peritoneal dialysis

    Suguru Yamamoto

    CEN Case Reports   2025年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/S13730-025-00981-8

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  • Nephrotic syndrome induces the upregulation of cell proliferation-related genes in tubular cells in mice

    Yuya Suzuki, Ryohei Kaseda, Yusuke Nakagawa, Hirofumi Watanabe, Tadashi Otsuka, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Taiji Matsusaka, Ichiei Narita

    Clinical and Experimental Nephrology   2024年12月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    Abstract

    Background

    Massive proteinuria, dyslipidemia, and hypoalbuminemia induced by nephrotic syndrome (NS) secondarily affect tubular cells. We conducted an RNA sequencing (RNA-seq) analysis using a mouse model of focal segmental glomerulosclerosis to clarify the impact of NS on tubular cells.

    Methods

    We used transgenic mice expressing hCD25 in podocytes (Nep25) to induce NS by injecting human CD25-specific immunotoxin (LMB2) at a dose of 0.625 ng/g body weight. Seven days after LMB2 injection, we extracted RNA from the whole kidney and conducted an RNA-seq analysis. Subsequently, we conducted multiple immunostaining and in situ hybridization (ISH) of differentially expressed genes (DEGs) to identify their locations and associated cell types. We also investigated the expression levels of DEGs in an additional mouse model of NS induced by adriamycin.

    Results

    After NS induction, 562 upregulated and 430 downregulated DEGs were identified using RNA-seq. An enrichment analysis revealed the upregulation of cell proliferation-related genes. We observed significant upregulation of Foxm1, a transcription factor linked to cell proliferation. Immunostaining and ISH showed that various tubular cells expressed Mki67 and Foxm1 during NS development. The adriamycin-induced NS model also demonstrated the upregulation of Mki67 and Foxm1 in tubular cells.

    Conclusions

    NS induced the upregulation of cell proliferation-related genes in tubular cells without detectable renal dysfunction. Our findings may contribute to understanding the pathological effects of nephrotic syndrome on tubular cells.

    DOI: 10.1007/s10157-024-02608-1

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  • Fanconi syndrome with acute proximal tubular injury induced by a dietary supplement containing beni-koji: a case series report. 国際誌

    Masato Habuka, Michihiro Hosojima, Yusuke Yata, Kenshiro Kurumada, Moeri Yamagiwa, Masataka Yonezawa, Masanori Sudo, Hideyuki Kabasawa, Asa Ogawa, Hitomi Hama, Yumi Ito, Naofumi Imai, Suguru Yamamoto, Akihiko Saito, Shin Goto

    BMC nephrology   25 ( 1 )   446 - 446   2024年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Fanconi syndrome is a disorder of the proximal tubule that leads to malabsorption of various electrolytes and substances and is a common consequence of drug-induced nephrotoxicity. However, cases of dietary supplement-induced Fanconi syndrome are rare, and detailed reports on the evaluation of renal histology in patients with this syndrome are lacking. CASE PRESENTATION: We present two cases of dietary supplement-induced Fanconi syndrome that was confirmed by kidney biopsy. Based on their medical history and laboratory and histological findings, both cases were diagnosed as acute proximal tubular injury caused by ingestion of a lipid-lowering dietary supplement containing beni-koji leading to Fanconi syndrome. After discontinuation of the dietary supplement and correction of dehydration and electrolyte imbalance, renal function completely recovered in one case but progressed to chronic kidney disease in the other. CONCLUSIONS: Clinicians should consider dietary supplement-induced Fanconi syndrome as a differential diagnosis in patients who become ill while taking a dietary supplement. Kidney biopsy is useful for diagnosing acute tubular injury with Fanconi syndrome and investigating its pathogenesis. Patients who have developed dietary supplement-induced Fanconi syndrome require long-term monitoring to detect and prevent progression to chronic kidney disease.

    DOI: 10.1186/s12882-024-03903-5

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  • Ectopic Production of Parathyroid Hormone and Production of Parathyroid Hormone-related Protein in Dedifferentiated Endometrial Carcinoma Induced Severe Hypercalcemia.

    Takeru Ogino, Hirofumi Watanabe, Shoko Yamazaki, Megumi Kurosawa, Akiko Kobayashi, Naofumi Imai, Takahiro Taguchi, Hajime Umezu, Ryo Aida, Kazuki Watanabe, Tadashi Otsuka, Hideyuki Kabasawa, Ryohei Kaseda, Suguru Yamamoto, Kosuke Yoshihara, Shin Goto, Ichiei Narita

    Internal medicine (Tokyo, Japan)   2024年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Hypercalcemia is a significant complication in cancer patients, primarily caused by parathyroid hormone-related peptide (PTHrP) and, rarely, by parathyroid hormone (PTH) production from tumors. We report a case of severe hypercalcemia in a woman with uterine cancer who exhibited elevated PTH and PTHrP levels. Surgical intervention revealed dedifferentiated endometrial carcinoma. Postoperatively, PTH and PTHrP levels normalized but subsequently increased due to metastases. A molecular analysis confirmed the expression of the PTH gene and protein within the tumor, indicating ectopic PTH production. In diagnosing and treating cancers, it is necessary to consider not only PTHrP production but also ectopic PTH production.

    DOI: 10.2169/internalmedicine.3899-24

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  • 網羅的遺伝子解析と蛋白構造予測で病原PKD1バリアントを同定し常染色体顕性(優性)多発性嚢胞腎と診断した一例

    椎谷 貴光, 渡辺 博文, 相田 涼, 大塚 忠司, 忰田 亮平, 山本 卓, 金子 佳賢, 後藤 眞

    日本腎臓学会誌   66 ( 6-E )   899 - 899   2024年9月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • 近位尿細管に限局した上皮細胞障害を呈したサプリメントによるファンコニー症候群の1例

    羽深 将人, 蒲澤 秀門, 細島 康宏, 小川 麻, 山本 卓, 伊藤 由美, 今井 直史, 後藤 眞

    日本腎臓学会誌   66 ( 6-E )   892 - 892   2024年9月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • マルチビタミンの長期過剰摂取による高Ca血症の遷延と二次性シュウ酸腎症を認めた一例

    入沢 大喜, 逸見 太郎, 後藤 佐和子, 蒲澤 秀門, 細島 康宏, 伊藤 由美, 今井 直史, 山本 卓, 後藤 眞, 成田 一衛

    日本腎臓学会誌   66 ( 6-E )   889 - 889   2024年9月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • The combined effect of leucine-enriched essential amino acid supplements and locomotion training on physical functions and quality of life in hemodialysis patients

    Kou Kitabayashi, Suguru Yamamoto, Yumi Katano, Ichiei Narita

    Renal Replacement Therapy   2024年6月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s41100-024-00551-1

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  • Frailty and Duration of Maintenance Dialysis: A Japanese Nationwide Cross-Sectional Study 査読

    Suguru Yamamoto

    American Journal of Kidney Diseases   (in press)   2024年6月

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1053/J.AJKD.2024.04.012

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  • Indoxyl Sulfate-Induced Macrophage Toxicity and Therapeutic Strategies in Uremic Atherosclerosis

    Takuya Wakamatsu, Suguru Yamamoto, Shiori Yoshida, Ichiei Narita

    Toxins   2024年5月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/toxins16060254

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  • Effectiveness of calcimimetics on fractures in dialysis patients with secondary hyperparathyroidism: meta-analysis of randomized trials 査読

    Takuya Wakamatsu, Suguru Yamamoto, Koji Matsuo, Masatomo Taniguchi, Takayuki Hamano, Masafumi Fukagawa, Junichiro James Kazama

    Journal of Bone and Mineral Metabolism   2024年5月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00774-024-01500-y

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  • Protein intake and its relationship with frailty in chronic kidney disease 査読

    Nobuyuki Shirai, Suguru Yamamoto, Yutaka Osawa, Atsuhiro Tsubaki, Shinichiro Morishita, Toshiko Murayama, Ichiei Narita

    Clinical and Experimental Nephrology   2024年5月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10157-023-02452-9

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  • シングルルーメンカテーテル有用性の検討

    吉澤 優太, 大塚 忠司, 山本 卓, 永野 敦嗣, 甲田 亮, 飯野 則昭, 宮崎 慧, 若松 拓也, 飯田 倫理, 青柳 竜治, 伊藤 徹, 亀田 茂美

    日本透析医学会雑誌   57 ( Suppl.1 )   619 - 619   2024年5月

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    記述言語:日本語   出版者・発行元:(一社)日本透析医学会  

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  • Polyacrylic acid-polyvinylpyrrolidone complex for achieving hemostasis after hemodialysis: study protocol for an open-label crossover randomized controlled trial (PAA-PVP study)

    Ryohei Terashima, Mototsugu Tanaka, Atsushi Hashimoto, Daiki Omori, Takahiro Tanaka, Haruna Miyazawa, Masahiro Ishizawa, Yoshihiko Tomita, Tomoko Ito, Yoshiyuki Koyama, Kokichi Saito, Suguru Yamamoto, Shin Goto, Ichiei Narita

    2024年4月

  • 慢性腎臓病における感染症の重症化に関連する因子の検討

    若松 拓也, 山本 卓, 成田 一衛

    新潟県医師会報   ( 888 )   8 - 9   2024年3月

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    記述言語:日本語   出版者・発行元:新潟県医師会  

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  • Supersaturation, a critical factor underlying proteostasis of amyloid fibril formation. 国際誌

    Yuji Goto, Kichitaro Nakajima, Suguru Yamamoto, Keiichi Yamaguchi

    Journal of molecular biology   168475 - 168475   2024年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    From a physicochemical viewpoint, amyloid fibril formation is a phase transition from soluble to crystal-like sates limited by supersaturation. It occurs only above solubility (i.e., the solubility limit) coupled with a breakdown of supersaturation. Although many studies have examined the role of molecular chaperones in the context of proteostasis, the role of supersaturation has not been addressed. Moreover, although molecular chaperone-dependent disaggregations have been reported for preformed amyloid fibrils, amyloid fibrils will not dissolve above the solubility of monomers, even if agitations fragment long fibrils to shorter amyloid particles. On the other hand, on considering a reversible and coupled equilibrium of interactions, folding/unfolding and amyloid formation/disaggregation, molecules stabilizing native states can work as a disaggregase reversing the amyloid fibrils to monomers. It is likely that the proteostasis network has various intra- and extracellular components which disaggregate preformed amyloid fibrils as well as prevent amyloid formation. Further studies with a view of solubility and supersaturation will be essential for comprehensive understanding of proteostasis.

    DOI: 10.1016/j.jmb.2024.168475

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  • Mass spectrometry-based proteomic analysis of proteins adsorbed by hexadecyl-immobilized cellulose bead column for the treatment of dialysis-related amyloidosis 査読

    Suguru Yamamoto

    Amyloid: the International Journal of Experimental and Clinical Investigation: the Official Journal of the International Society of Amyloidosis   2024年

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    担当区分:筆頭著者, 責任著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/13506129.2024.2315148

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  • Association of Nutritional Risk Index With Infection-Related Hospitalization and Death After Hospitalization in Patients Undergoing Maintenance Hemodialysis

    Katsuhito Mori, Yosuke Yamamoto, Norio Hanafusa, Suguru Yamamoto, Shingo Fukuma, Yoshihiro Onishi, Masanori Emoto, Masaaki Inaba

    Journal of Renal Nutrition   2024年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1053/j.jrn.2024.07.017

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  • A case of multiorgan failure due to carbamazepine intoxication successfully treated with multimodal blood purification therapy

    Suguru Yamamoto

    CEN Case Reports   2024年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/S13730-024-00900-3

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  • <i>Tsukamurella conjunctivitidis</i> peritonitis diagnosed by 16S rRNA gene sequencing in a patient undergoing peritoneal dialysis

    Suguru Yamamoto

    CEN Case Reports   2024年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/S13730-024-00958-Z

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  • シングルルーメンカテーテルの有用性について

    吉澤 優太, 大塚 忠司, 山本 卓, 永野 敦嗣, 甲田 亮, 飯野 則昭, 宮崎 慧, 若松 拓也, 飯田 倫理, 青柳 竜治, 伊藤 徹, 亀田 茂美, 成田 一衛

    Niigata Blood Purification Conferenceプログラム・一般演題抄録   2023   10 - 10   2023年12月

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    記述言語:日本語   出版者・発行元:Niigata Blood Purification Conference事務局  

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  • Frailty in Patients on Dialysis Surviving for More than 40 Years is Common and Severe: A Nationwide Cross-Sectional Study

    Yamamoto Suguru, Niihata Kakuya, Toida Tatsunori, Abe Masanori, Hanafusa Norio, Kurita Noriaki

    SSRN (プレプリント)   2023年10月

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  • Active vitamin D use and fractures in hemodialysis patients: Results from the international DOPPS. 査読 国際誌

    Hirotaka Komaba, Junhui Zhao, Angelo Karaboyas, Suguru Yamamoto, Indranil Dasgupta, Mohamed Hassan, Li Zuo, Anders Christensson, Christian Combe, Bruce Robinson M, Masafumi Fukagawa

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research   2023年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Active vitamin D is commonly used to control secondary hyperparathyroidism in dialysis patients, but it is unknown whether active vitamin D directly improves bone strength, independent of its effect to suppress parathyroid hormone (PTH). We analyzed the association between prescription of active vitamin D and incidence of any fracture and hip fracture in 41,677 in-center hemodialysis patients from 21 countries in phases 3-6 (2005-2018) of the Dialysis Outcomes and Practice Patterns Study (DOPPS). We used Cox regression, adjusted for PTH and other potential confounders, and used a per-protocol approach to censor patients at treatment switch during follow-up. We also used a facility preference approach to minimize confounding by indication. Overall, 55% of patients were prescribed active vitamin D at study enrollment. Event rates (per patient-year) were 0.024 for any fracture and 0.010 for hip fracture. The adjusted hazard ratio (95% confidence interval) comparing patients prescribed vs. not prescribed active vitamin D was 1.02 (0.90-1.17) for any fracture and 1.00 (0.81-1.23) for hip fracture. In the facility preference approach, there was no difference in fracture rate between facilities with higher vs. lower active vitamin D prescriptions. Thus, our results do not suggest a PTH-independent benefit of active vitamin D in fracture prevention and support the current KDIGO guideline suggesting the use of active vitamin D only in subjects with elevated or rising PTH. Further research is needed to determine the role of active vitamin D beyond PTH control. This article is protected by copyright. All rights reserved.

    DOI: 10.1002/jbmr.4913

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  • A Case of Systemic Amyloid A Amyloidosis Secondary to Xanthogranulomatous Pyelonephritis. 査読

    Masato Habuka, Mizusa Nishikiori, Chihiro Oikawa, Megumi Takahashi, Yuichi Sakamaki, Asa Ogawa, Norio Miyajima, Yasuhiko Tanabe, Keiichi Honma, Kunihiko Wakaki, Suguru Yamamoto, Ichiei Narita

    Internal medicine (Tokyo, Japan)   2023年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The combination of systemic amyloid A (AA) amyloidosis and xanthogranulomatous pyelonephritis (XGP) resulting from a chronic urinary tract infection is extremely rare. We herein report a case of systemic AA amyloidosis secondary to XGP for which clinical remission developed after nephrectomy. To our knowledge, this is the first case report describing the clinical improvement of systemic AA amyloidosis secondary XGP after nephrectomy in Japan. Clinicians should be aware of this uncommon combination and search for amyloid depositions in cases of XGP.

    DOI: 10.2169/internalmedicine.1806-23

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  • Sodium magnetic resonance imaging shows impairment of the counter-current multiplication system in diabetic mice kidney. 査読 国際誌

    Yusuke Nakagawa, Ryohei Kaseda, Yuya Suzuki, Hirofumi Watanabe, Tadashi Otsuka, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Yasuhiko Terada, Tomoyuki Haishi, Susumu Sasaki, Ichiei Narita

    Kidney360   4 ( 5 )   582 - 590   2023年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Sodium magnetic resonance imaging can non-invasively assess sodium distribution, specifically sodium concentration in the countercurrent multiplication system in the kidney, which forms a sodium concentration gradient from the cortex to the medulla, enabling efficient water reabsorption. This study aimed to investigate whether sodium magnetic resonance imaging can detect changes in sodium concentrations under normal conditions in mice and in disease models such as a mouse model with diabetes mellitus. Methods: We performed sodium and proton nuclear magnetic resonance imaging using a 9.4-T vertical standard-bore super-conducting magnet. Results: A condition of deep anesthesia, with widened breath intervals, or furosemide administration in 6-week-old C57BL/6JJcl mice showed a decrease in both tissue sodium concentrations in the medulla and sodium concentration gradients from the cortex to the medulla. Further, sodium magnetic resonance imaging revealed reductions in the sodium concentration of the medulla and in the gradient from the cortex to the medulla in BKS.Cg-Leprdb+/+ Leprdb/Jcl mice at very early type-2 diabetes mellitus stages compared to corresponding control BKS.Cg-m+/m+/Jcl mice. Conclusions: The kidneys of BKS.Cg-Leprdb+/+ Leprdb/Jcl mice aged 6 weeks showed impairments in the countercurrent multiplication system. We propose the utility of 23Na MRI for evaluating functional changes in diabetic kidney disease, not as markers that reflect structural damage. Thus, 23Na MRI may be a potential very early marker for structures beyond the glomerulus; this may prompt intervention with novel efficacious tubule-targeting therapies.

    DOI: 10.34067/KID.0000000000000072

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  • Assessing fluid volume and determining outcomes of acute heart failure using plasma human atrial natriuretic peptide. 査読

    Yuya Suzuki, Tadashi Otsuka, Yuki Yoshioka, Tomomichi Iida, Shingo Maruyama, Hirofumi Watanabe, Ryohei Kaseda, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Ryuji Aoyagi, Ichiei Narita

    Clinical and experimental nephrology   27 ( 6 )   565 - 573   2023年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The post-dialysis plasma level of human atrial natriuretic peptide (hANP) reflects the fluid volume in patients on hemodialysis. The threshold hANP level is reportedly 100 pg/mL; however, the clinical usefulness of the threshold hANP level for volume control has not been sufficiently studied. METHODS: We conducted a single-center, retrospective, observational study that included 156 hemodialysis patients without atrial fibrillation. First, we examined the usefulness of the threshold hANP level (100 pg/mL) for predicting hypoxemia due to congestion in a short-term observational study from December 30, 2015 to January 5, 2016. Subsequently, we conducted a 5-year follow-up study wherein the outcomes were hospitalization due to acute heart failure (AHF), development of cardiovascular diseases (CVD), and all-cause death. Finally, we collected echocardiography data to investigate the relationship between cardiac function and hANP. RESULTS: Our short-term observational study showed that patients with an hANP level ≥ 100 pg/mL developed hypoxemia due to congestion (odds ratio, 3.52; 95% confidence interval, 1.06-11.71; P = 0.040). At the 5-year follow-up, patients with an hANP level ≥ 100 pg/mL had significantly higher rates of hospitalization due to AHF, CVD, and all-cause death based on the log-rank test (P = 0.003, P = 0.019, P < 0.001, respectively). Cardiac disfunctions were significantly associated with the high hANP level. CONCLUSIONS: The hANP level is indicative of both fluid volume and cardiac dysfunction. A threshold hANP level of 100 pg/mL can serve as a predictive marker for AHF and a practical indicator for volume control.

    DOI: 10.1007/s10157-023-02333-1

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  • THE EVALUATION OF FLUID VOLUME AND PROGNOSIS IN HEMODIALYSIS PATIENTS UTILIZING PLASMA HUMAN ATRIAL NATRIURETIC PEPTIDE

    Suguru Yamamoto

    Nephrology Dialysis Transplantation   2023年

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    掲載種別:研究論文(学術雑誌)  

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  • Secondary hyperparathyroidism, weight loss, and longer term mortality in haemodialysis patients: results from the DOPPS 査読 国際誌

    Hirotaka Komaba, Junhui Zhao, Suguru Yamamoto, Takanobu Nomura, Douglas S. Fuller, Keith P. McCullough, Pieter Evenepoel, Anders Christensson, Xinju Zhao, Mona Alrukhaimi, Fadwa Al‐Ali, Eric W. Young, Bruce M. Robinson, Masafumi Fukagawa

    Journal of Cachexia, Sarcopenia and Muscle   12 ( 4 )   855 - 865   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    BACKGROUND: Wasting is a common complication of kidney failure that leads to weight loss and poor outcomes. Recent experimental data identified parathyroid hormone (PTH) as a driver of adipose tissue browning and wasting, but little is known about the relations among secondary hyperparathyroidism, weight loss, and risk of mortality in dialysis patients. METHODS: We included 42,319 chronic in-centre haemodialysis patients from the Dialysis Outcomes and Practice Patterns Study phases 2-6 (2002-2018). Linear mixed models were used to estimate the association between baseline PTH and percent weight change over 12 months, adjusting for country, demographics, comorbidities, and labs. Accelerated failure time models were used to assess 12 month weight loss as a mediator between baseline high PTH and mortality after 12 months. RESULTS: Baseline PTH was inversely associated with 12 month weight change: 12 month weight loss >5% was observed in 21%, 18%, 18%, 17%, 15%, and 14% of patients for PTH ≥600 pg/mL, 450-600, 300-450, 150-300, 50-150, and <50 pg/mL, respectively. In adjusted analyses, 12 month weight change compared with PTH 150-299 pg/mL was -0.60%, -0.12%, -0.10%, +0.15%, and +0.35% for PTH ≥600, 450-600, 300-450, 50-150, and <50 pg/mL, respectively. This relationship was robust regardless of recent hospitalization and was more pronounced in persons with preserved appetite. During follow-up after the 12 month weight measure [median, 1.0 (interquartile range, 0.6-1.7) years; 6125 deaths], patients with baseline PTH ≥600 pg/mL had 11% [95% confidence interval (CI), 9-13%] shorter lifespan, and 18% (95% CI, 14-23%) of this effect was mediated through weight loss ≥2.5%. CONCLUSIONS: Secondary hyperparathyroidism may be a novel mechanism of wasting, corroborating experimental data, and, among chronic dialysis patients, this pathway may be a mediator between elevated PTH levels and mortality. Future research should determine whether PTH-lowering therapy can limit weight loss and improve longer term dialysis outcomes.

    DOI: 10.1002/jcsm.12722

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  • Erratum to: Aberrant mucosal immunoreaction to tonsillar microbiota in immunoglobulin A nephropathy. 国際誌

    Hiroki Yamaguchi, Shin Goto, Nao Takahashi, Masafumi Tsuchida, Hirofumi Watanabe, Suguru Yamamoto, Yoshikatsu Kaneko, Koichi Higashi, Hiroshi Mori, Yukio Nakamura, Arata Horii, Ken Kurokawa, Ichiei Narita

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/ndt/gfaa319

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  • Aberrant mucosal immunoreaction to tonsillar microbiota in immunoglobulin A nephropathy 査読 国際誌

    Hiroki Yamaguchi, Shin Goto, Nao Takahashi, Masafumi Tsuchida, Hirofumi Watanabe, Suguru Yamamoto, Yoshikatsu Kaneko, Koichi Higashi, Hiroshi Mori, Yukio Nakamura, Arata Horii, Ken Kurokawa, Ichiei Narita

    Nephrology Dialysis Transplantation   36 ( 1 )   75 - 86   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oxford University Press (OUP)  

    <title>Abstract</title>
    <sec>
    <title>Background</title>
    Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis worldwide, characterized by mesangial polymeric IgA1 deposition. IgAN is believed to develop owing to aberrant mucosal immunoreaction against commensals in the tonsils. However, the exact interrelation between pathogenic IgA and mucosal microbiota in IgAN patients is unclear.


    </sec>
    <sec>
    <title>Methods</title>
    Biopsy-proven IgAN or recurrent tonsillitis (RT) patients who had undergone tonsillectomy were enrolled. We used 16S ribosomal RNA gene amplicon sequencing with a flow cytometry-based bacterial cell sorting technique) and immunoglobulin repertoire sequencing of the IgA heavy chain to characterize IgA-coated bacteria of the tonsillar microbiota (IgA-SEQ) and their corresponding IgA repertoire. Furthermore, we fractionated patient serum using gel-filtration chromatography and performed flow cytometry-based analysis of IgA binding to bacteria cultured from incised tonsils.


    </sec>
    <sec>
    <title>Results</title>
    Tonsillar proliferation-inducing ligand and B-cell activating factor levels were significantly higher in IgAN than in RT patients. IgA-SEQ for tonsillar microbiota revealed the preferential binding ability of IgA to Bacteroidetes in IgAN tonsils compared with those from RT patients. Expression of immunoglobulin heavy (IGH) constant alpha 1 with IGH variable 3–30 was significantly higher in IgAN than that in RT, and positively correlated with the IgA-coated enrichment score of Bacteroidetes. Serum polymeric IgA, comprising high levels of GdIgA1, exhibited considerable binding to Bacteroidetes strains cultured from the tonsils of IgAN patients.


    </sec>
    <sec>
    <title>Conclusions</title>
    These findings provide evidence that aberrant mucosal immune responses to tonsillar anaerobic microbiota, primarily consisting of members of the phylum Bacteroidetes, are involved in IgAN pathophysiology.


    </sec>

    DOI: 10.1093/ndt/gfaa223

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  • Type-I Angiotensin II Receptor Blockade Reduces Uremia-induced Deterioration of Bone Material Properties. 査読 国際誌

    Takuya Wakamatsu, Yoshiko Iwasaki, Suguru Yamamoto, Koji Matsuo, Shin Goto, Ichiei Narita, Junichiro J Kazama, Kennichi Tanaka, Akemi Ito, Ryosuke Ozasa, Takayoshi Nakano, Chisato Miyakoshi, Yoshihiro Onishi, Shingo Fukuma, Shunichi Fukuhara, Hideyuki Yamato, Masafumi Fukagawa, Tadao Akizawa

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research   36 ( 1 )   67 - 79   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Chronic kidney disease (CKD) is associated with a high incidence of fractures. However, the pathophysiology of this disease is not fully understood, and limited therapeutic interventions are available. This study aimed to determine the impact of type-1 angiotensin II receptor blockade (AT-1RB) on preventing CKD-related fragility fractures and elucidate its pharmacological mechanisms. AT-1RB use was associated with a lower risk of hospitalization due to fractures in 3276 patients undergoing maintenance hemodialysis. In nephrectomized rats, administration of olmesartan suppressed osteocyte apoptosis, skeletal pentosidine accumulation and apatite disorientation, and partially inhibited the progression of the bone elastic mechanical properties, while the bone mass unchanged. Olmesartan suppressed angiotensin II-dependent oxidation stress and apoptosis in primary cultured osteocytes in vitro. In conclusion, angiotensin II-dependent intraskeletal oxidation stress deteriorated the bone elastic mechanical properties by promoting osteocyte apoptosis and pentosidine accumulation. Thus, AT-1RB contributes to the underlying pathogenesis of abnormal bone quality in the setting of CKD, possibly by oxidative stress.

    DOI: 10.1002/jbmr.4159

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  • FGF23 and mortality among prevalent hemodialysis patients in the Japan Dialysis Outcomes and Practice Patterns Study 査読

    Hirotaka Komaba, Douglas S. Fuller, Masatomo Taniguchi, Suguru Yamamoto, Takanobu Nomura, Junhui Zhao, Brian A. Bieber, Bruce M. Robinson, Ronald L. Pisoni, Masafumi Fukagawa

    Kidney International Reports   2020年8月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.ekir.2020.08.013

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  • Effect of sucroferric oxyhydroxide on gastrointestinal microbiome and uremic toxins in patients with chronic kidney disease undergoing hemodialysis. 査読

    Akira Iguchi, Suguru Yamamoto, Akira Oda, Kenichi Tanaka, Junichiro James Kazama, Takako Saeki, Hajime Yamazaki, Ken Ishioka, Tatsuo Suzutani, Ichiei Narita

    Clinical and experimental nephrology   24 ( 8 )   725 - 733   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: In patients with chronic kidney disease (CKD), dysbiosis in the gastrointestinal microbiome is thought to be associated with increased production of uremic toxins, such as indoxyl sulfate (IS) and p-cresyl sulfate (PCS). Sucroferric oxyhydroxide (SFO), an iron-based phosphate binder, may affect the gastrointestinal microbiome and the production of uremic toxins. We aimed to examine whether SFO administration affected distribution of gastrointestinal microbiome and serum uremic toxin levels in CKD patients undergoing hemodialysis. METHODS: In this single-center, open-label, interventional study, 18 maintenance hemodialysis patients with hyperphosphatemia were prescribed with SFO. We collected serum samples before and after 3 months of administration, and serum levels of IS and PCS were measured. A control group of 20 hemodialysis patients without SFO was evaluated. We evaluated gastrointestinal microbiome of patients pre- and post-SFO administration by 16S rDNA sequencing and bioinformatics analysis. RESULTS: Serum IS and PCS levels were significantly elevated after administration of SFO (IS before 2.52 ± 1.60 mg/dl vs. after 3.13 ± 1.51 mg/dl, P = 0.008; PCS before 2.32 ± 2.44 mg/dl vs. after 3.45 ± 2.11 mg/dl, P = 0.002), while serum IS and PCS levels did not change in the control group. Microbiome analysis in the SFO group showed no significant change in diversity and major components in phylum, class, order, family, gene, and species. CONCLUSION: Administration of SFO increased the serum levels of IS and PCS with no change of major components of gastrointestinal microbiome.

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  • SEVERITY OF PRURITUS IN HEMODIALYSIS PATIENTS: RELATIONSHIP TO UREMIC TOXINS AND DIALYSIS MODALITY

    Suguru Yamamoto

    Nephrology Dialysis Transplantation   2020年

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    掲載種別:研究論文(学術雑誌)  

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  • PRIORITIZATION BY MEDICAL DIRECTORS OF NUTRITIONAL PROTEIN VERSUS DIETARY PHOSPHORUS CONTROL IN HEMODIALYSIS PATIENTS: ASSOCIATION WITH MORTALITY IN THE DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (DOPPS)

    Suguru Yamamoto

    Nephrology Dialysis Transplantation   2020年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/NDT/GFAA142|III1769

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  • 血液透析患者における透析実施時間帯の早朝空腹時呼吸商に及ぼす影響の検討

    北林 紘, 片野 佑美, 山本 卓, 石井 雄士

    日本栄養士会雑誌   62 ( 12 )   641 - 647   2019年12月

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    記述言語:日本語   出版者・発行元:(公社)日本栄養士会  

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  • Disrupted tubular parathyroid hormone/parathyroid hormone receptor signaling and damaged tubular cell viability possibly trigger postsurgical kidney injury in patients with advanced hyperparathyroidism. 査読

    Sato T, Kikkawa Y, Yamamoto S, Tanaka Y, Kazama JJ, Tominaga Y, Ichimori T, Okada M, Hiramitsu T, Fukagawa M

    Clinical kidney journal   12 ( 5 )   686 - 692   2019年10月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/ckj/sfy136

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  • Possible mechanisms of polyphosphate-induced amyloid fibril formation of β<sub>2</sub>-microglobulin. 査読

    Zhang CM, Yamaguchi K, So M, Sasahara K, Ito T, Yamamoto S, Narita I, Kardos J, Naiki H, Goto Y

    Proceedings of the National Academy of Sciences of the United States of America   116 ( 26 )   12833 - 12838   2019年6月

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  • The features of bone articular lesions in dialysis-related amyloidosis (DRA) and criteria for the clinical diagnosis of DRA 査読

    Suguru Yamamoto

    Renal Replacement Therapy   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/S41100-019-0205-Z

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  • Cryofibrinogen-associated glomerulonephritis diagnosed by mass spectrometry and immunoelectron microscopy 査読

    Masanori Sudo, Yuichi Sakamaki, Michihiro Hosojima, Suguru Yamamoto, Yumi Ito, Naofumi Imai, Yoshikatsu Kaneko, Shin Goto, Chih Ping Li, Akira Shimizu, Ichiei Narita

    Human Pathology: Case Reports   15   83 - 87   2019年3月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ehpc.2018.12.002

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  • Successful treatment of gamma 1 heavy chain deposition disease with bortezomib and dexamethasone

    Suguru Yamamoto

    Human Pathology: Case Reports   2019年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/J.EHPC.2019.01.001

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  • Attenuated Macrophage Infiltration in Glomeruli of Aged Mice Resulting in Ameliorated Kidney Injury in Nephrotoxic Serum Nephritis. 査読

    Kaneko Y, Cho T, Sato Y, Goto K, Yamamoto S, Goto S, Madaio MP, Narita I

    The journals of gerontology. Series A, Biological sciences and medical sciences   73 ( 9 )   1178 - 1186   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/gerona/gly019

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  • 自己末梢血幹細胞移植後に血栓性微小血管症(TMA)による腎障害を合併した一例

    白柏 由佳, 後藤 佐和子, 細島 康宏, 保坂 聖子, 山本 卓, 今井 直史, 伊藤 由美, 後藤 眞, 成田 一衛

    日本腎臓学会誌   60 ( 6 )   876 - 876   2018年8月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • Multicentre cross-sectional study for bone-articular lesions associated with dialysis related amyloidosis in Japan. 査読

    Nishi S, Hoshino J, Yamamoto S, Goto S, Fujii H, Ubara Y, Motomiya Y, Morita H, Takaichi K, Yamagata K, Shigematsu T, Ueda M, Ando Y

    Nephrology (Carlton, Vic.)   23 ( 7 )   640 - 645   2018年7月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/nep.13077

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  • ABO血液型不適合生体腎移植前に行った二重膜濾過血漿交換施行中に全身膨隆疹を発症した一例

    宮内 大輔, 斎藤 将名, 土田 良樹, 谷江 駿矢, 近藤 友希, 長谷川 進, 西塔 毅, 田崎 正行, 中川 由紀, 齋藤 和英, 蒲澤 秀門, 山本 卓, 成田 一衛

    日本臨床工学技士会会誌   ( 63 )   194 - 194   2018年4月

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    記述言語:日本語   出版者・発行元:(公社)日本臨床工学技士会  

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  • Fatal visceral disseminated varicella zoster infection during initial remission induction therapy in a patient with lupus nephritis and rheumatoid arthritis - Possible association with mycophenolate mofetil and high-dose glucocorticoid therapy: A case report 査読

    Masato Habuka, Yoko Wada, Yoichi Kurosawa, Suguru Yamamoto, Yusuke Tani, Riuko Ohashi, Yoichi Ajioka, Masaaki Nakano, Ichiei Narita

    BMC Research Notes   11 ( 1 )   165   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BioMed Central Ltd.  

    DOI: 10.1186/s13104-018-3271-3

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  • Kidney morphological parameters measured using noncontrast-enhanced steady-state free precession MRI with spatially selective inversion recovery pulse correlate with eGFR in patients with advanced CKD 査読

    Tadashi Otsuka, Yoshikatsu Kaneko, Yuya Sato, Ryohei Kaseda, Ryuji Aoyagi, Suguru Yamamoto, Shin Goto, Ichiei Narita

    Clinical and Experimental Nephrology   22 ( 1 )   45 - 54   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10157-017-1413-x

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  • INDOXYL SULFATE AND MORTALITY IN HAEMODIALYSIS PATIENTS: RESULTS FROM THE JAPAN DIALYSIS OUTCOMESAND PRACTICE PATTERNS STUDY (J-DOPPS)

    Suguru Yamamoto

    Nephrology Dialysis Transplantation   2018年

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    掲載種別:研究論文(学術雑誌)  

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  • Suction towards a vessel wall by hemodialysis catheters—the establishment of a new experimental extracorporeal circulation system using pig veins

    Suguru Yamamoto

    Renal Replacement Therapy   2018年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/S41100-018-0161-Z

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  • ヘキサデキル基固定セルロースビーズによる蛋白結合尿毒症物質の吸着効果

    山本 卓, 佐藤 茉美, 佐藤 容子, 若松 拓也, 高橋 良光, 井口 昭, 大森 健太郎, 鈴木 靖, 惠 以盛, 金子 佳賢, 後藤 眞, 風間 順一郎, 下條 文武, 成田 一衛

    日本透析医会雑誌   32 ( 3 )   516 - 519   2017年12月

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    記述言語:日本語   出版者・発行元:(公社)日本透析医会  

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  • Effect of ferric citrate hydrate on FGF23 and PTH levels in patients with non-dialysis-dependent chronic kidney disease with normophosphatemia and iron deficiency 査読

    Akira Iguchi, Suguru Yamamoto, Mihoko Yamazaki, Kazuyuki Tasaki, Yasushi Suzuki, Junichiro James Kazama, Ichiei Narita

    Clinical and Experimental Nephrology   22 ( 4 )   1 - 8   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10157-017-1510-x

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  • 原因不明の低Na血症および急性肺水腫に対してCHDFが奏功した一例

    村竹 佑太, 黒澤 陽一, 若松 拓也, 細島 康宏, 保坂 聖子, 山本 卓, 後藤 眞, 成田 一衛

    新潟急性血液浄化研究会抄録集   4回   6 - 7   2017年11月

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    記述言語:日本語   出版者・発行元:新潟急性血液浄化研究会  

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  • Prevalence of Earlobe Creases and Their Association With History of Cardiovascular Disease in Patients Undergoing Hemodialysis: A Cross-Sectional Study 査読

    Minako Wakasugi, Junichiro James Kazama, Kazuko Kawamura, Suguru Yamamoto, Masaaki Nagai, Kentaro Omori, Saori Yokota, Hirokazu Fujikawa, Ikuo Aoike, Tsukasa Omori, Ichiei Narita

    Therapeutic Apheresis and Dialysis   21 ( 5 )   478 - 484   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/1744-9987.12567

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  • Initiation of Sevelamer and Mortality among Hemodialysis Patients Treated with Calcium-Based Phosphate Binders 査読

    Hirotaka Komaba, Mia Wang, Masatomo Taniguchi, Suguru Yamamoto, Takanobu Nomura, Douglas E. Schaubel, Abigail R. Smith, Jarcy Zee, Angelo Karaboyas, Brian Bieber, Masafumi Fukagawa, Francesca Tentori

    CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   12 ( 9 )   1489 - 1497   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2215/CJN.13091216

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  • ボルテゾミブが奏功した意義不明の単クローン性ガンマグロブリン血症(MGUS)に伴う重鎖沈着症(HCDD)の一例

    須藤 真則, 若松 拓也, 石川 友美, 羽深 将人, 細島 康宏, 山本 卓, 伊藤 由美, 今井 直史, 金子 佳賢, 瀧澤 淳, 成田 一衛

    日本腎臓学会誌   59 ( 6 )   869 - 869   2017年9月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • Potential Benefit Associated With Delaying Initiation of Hemodialysis in a Japanese Cohort. 査読 国際誌

    Higuchi S, Nakaya I, Yoshikawa K, Chikamatsu Y, Sada KE, Yamamoto S, Takahashi S, Sasaki H, Soma J

    Kidney international reports   2 ( 4 )   594 - 602   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ekir.2017.01.015

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  • Prolactin Upregulates Female-Predominant P450 Gene Expressions and Downregulates Male-Predominant Gene Expressions in Mouse Liver 査読

    Yuya Sato, Yoshikatsu Kaneko, Takamasa Cho, Kei Goto, Tadashi Otsuka, Suguru Yamamoto, Shin Goto, Hiroki Maruyama, Ichiei Narita

    DRUG METABOLISM AND DISPOSITION   45 ( 6 )   586 - 592   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1124/dmd.116.074658

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  • Comparison of methods of steroid administration combined with tonsillectomy for IgA nephropathy patients 査読

    Hirofumi Watanabe, Shin Goto, Daisuke Kondo, Takuma Takata, Hajime Yamazaki, Michihiro Hosojima, Suguru Yamamoto, Yoshikatsu Kaneko, Ryuji Aoyagi, Ichiei Narita

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   21 ( 2 )   257 - 265   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10157-016-1282-8

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  • インドキシル硫酸はマクロファージのAhR/NF-κB/MAPK系を活性化させる一方、NLRP3インフラマソーム活性を抑制する

    若松 拓也, 山本 卓, 松尾 浩司, 金子 佳賢, 後藤 眞, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   59 ( 3 )   283 - 283   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • レニン-アンギオテンシン系阻害は腎不全ラットの破骨細胞活性を抑制し、石灰化障害を改善させる

    佐藤 容子, 若松 拓也, 山本 卓, 伊藤 明美, 岩崎 香子, 金子 佳賢, 後藤 眞, 深川 雅史, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   59 ( 3 )   276 - 276   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • Net cholesterol efflux capacity of HDL enriched serum and coronary atherosclerosis in rheumatoid arthritis 査読

    Suguru Yamamoto

    IJC Metabolic & Endocrine   13   6 - 11   2016年12月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/J.IJCME.2016.08.002

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  • 透析非導入に至った超高齢者慢性腎臓病患者の1例

    山本 卓, 吉澤 優太, 後藤 慧, 高井 千夏, 酒巻 裕一, 金子 佳賢, 後藤 眞, 風間 順一郎, 丸山 弘樹, 成田 一衛

    日本老年医学会雑誌   53 ( 4 )   447 - 448   2016年10月

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    記述言語:日本語   出版者・発行元:(一社)日本老年医学会  

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  • [Teriparatide:benefit and safety for bone disease in CKD patients undergoing hemodialysis]. 査読

    Yamamoto S, Ei I, Narita I

    Clinical calcium   26 ( 9 )   1301 - 1307   2016年9月

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    担当区分:筆頭著者, 責任著者  

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  • Extracapillary proliferation and arteriolar hyalinosis are associated with long-term kidney survival in IgA nephropathy 査読

    Yoshikatsu Kaneko, Kazuhiro Yoshita, Emiko Kono, Yumi Ito, Naofumi Imai, Suguru Yamamoto, Shin Goto, Ichiei Narita

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   20 ( 4 )   569 - 577   2016年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10157-015-1185-0

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  • 治療中に播種性水痘感染を発症したループス腎炎の2例

    羽深 将人, 永野 敦嗣, 細島 康宏, 山本 卓, 中枝 武司, 和田 庸子, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   58 ( 6 )   779 - 779   2016年8月

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  • 血液透析導入後に腎生検を施行しIgA腎症と診断した一例

    熊木 隆之, 石川 友美, 羽深 将人, 細島 康宏, 山本 卓, 今井 直史, 伊藤 由美, 風間 順一郎, 成田 一衛

    日本透析医学会雑誌   49 ( Suppl.1 )   583 - 583   2016年5月

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    記述言語:日本語   出版者・発行元:(一社)日本透析医学会  

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  • ヘキサデシル基固定セルロースビーズは蛋白結合尿毒症物質を吸着する

    山本 卓, 風間 順一郎, 佐藤 茉美, 若松 拓也, 高橋 良光, 惠 以盛, 大森 健太郎, 井口 昭, 鈴木 靖, 成田 一衛

    日本透析医学会雑誌   49 ( Suppl.1 )   530 - 530   2016年5月

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  • レニン-アンギオテンシン系阻害は腎不全ラットの骨石灰化と弾性を改善させる

    若松 拓也, 山本 卓, 松尾 浩司, 岩崎 香子, 伊藤 明美, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   58 ( 3 )   293 - 293   2016年5月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • Leptin deficiency down-regulates IL-23 production in glomerular podocytes resulting in an attenuated immune response in nephrotoxic serum nephritis 査読

    Kei Goto, Yoshikatsu Kaneko, Yuya Sato, Tadashi Otsuka, Suguru Yamamoto, Shin Goto, Keiko Yamamoto, Tadashi Yamamoto, Hiroshi Kawachi, Michael P. Madaio, Ichiei Narita

    INTERNATIONAL IMMUNOLOGY   28 ( 4 )   197 - 208   2016年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/intimm/dxv067

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  • Is IgA nephropathy (IgAN) a familial or sporadic disease? 査読

    Ichiei Narita, Yoshikatsu Kaneko, Yumi Itoh, Yuichi Sakamaki, Seitaro Iguchi, Suguru Yamamoto, Minako Wakasugi, Junichiro J. Kazama, Shin Goto

    Pathogenesis and Treatment in IgA Nephropathy: An International Comparison   43 - 51   2016年3月

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    記述言語:英語   掲載種別:論文集(書籍)内論文   出版者・発行元:Springer Japan  

    DOI: 10.1007/978-4-431-55588-9_3

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  • Removal of uremic toxins by renal replacement therapies: a review of current progress and future perspectives

    Suguru Yamamoto

    Renal Replacement Therapy   2016年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/S41100-016-0056-9

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  • Intact parathyroid hormone and whole parathyroid hormone assay results disagree in hemodialysis patients under cinacalcet hydrochloride therapy 査読

    Ryo Koda, Junichiro James Kazama, Koji Matsuo, Kazuko Kawamura, Suguru Yamamoto, Minako Wakasugi, Tetsuro Takeda, Ichiei Narita

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   19 ( 4 )   710 - 717   2015年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10157-014-1045-3

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  • 生体腎移植2例が長期生着中の家族性巣状分節性糸球体硬化症の1家系

    坪野 俊介, 酒巻 裕一, 山本 卓, 今井 直史, 伊藤 由美, 田崎 正行, 中川 由紀, 齋藤 和英, 後藤 眞, 高橋 公太, 成田 一衛

    日本腎臓学会誌   57 ( 6 )   947 - 947   2015年8月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • TAFRO症候群に合併した急性腎障害に対してCRRTを要した1例

    須藤 真則, 酒巻 裕一, 若松 彩子, 渡辺 博文, 蒲澤 秀門, 山本 卓, 金子 佳賢, 山崎 肇, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   57 ( 6 )   951 - 951   2015年8月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • Advanced Thymic Cancer Treated with Carboplatin and Paclitaxel in a Patient Undergoing Hemodialysis 査読

    Satoru Miura, Hiroshi Kagamu, Takehito Sakai, Koichiro Nozaki, Katsuaki Asakawa, Hiroshi Moro, Masaaki Okajima, Satoshi Watanabe, Suguru Yamamoto, Noriaki Iino, Shin Goto, Junichiro James Kazama, Hirohisa Yoshizawa, Ichiei Narita

    INTERNAL MEDICINE   54 ( 1 )   55 - 58   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.54.3484

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  • Administration of Ferric Citrate Hydrate Decreases Circulating FGF23 Levels Independently of Serum Phosphate Levels in Hemodialysis Patients with Iron Deficiency 査読

    Akira Iguchi, Junichiro J. Kazama, Suguru Yamamoto, Kazuhiro Yoshita, Yasuo Watanabe, Noriaki Iino, Ichiei Narita

    NEPHRON   131 ( 3 )   161 - 166   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000440968

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  • ブタ静脈血管を用いた短期カテーテルの評価システムの開発に関する検討

    髙橋 良光, 風間 順一郎, 山本 卓, 成田 一衛, 追手 巍

    日本透析医学会雑誌   48 ( 6 )   393 - 394   2015年

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    記述言語:日本語   出版者・発行元:The Japanese Society for Dialysis Therapy  

    DOI: 10.4009/jsdt.48.393

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    その他リンク: http://search.jamas.or.jp/link/ui/2015372426

  • 経皮的腎動脈形成術により腎機能の著明な改善が得られた片側腎動脈狭窄の一例

    大塚 忠司, 酒巻 裕一, 山本 卓, 金子 佳賢, 伊藤 由美, 今井 直史, 成田 一衛, 猪俣 繁, 捧 博輝

    日本腎臓学会誌   56 ( 6 )   863 - 863   2014年8月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • A hip fracture in a dialysis patient with Aβ2M amyloidosis. 査読

    Kazama JJ, Yamamoto S, Wakasugi M, Narita I

    Kidney international   85 ( 1 )   214 - 215   2014年1月

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  • 肝性脳症による意識障害が血液透析濾過により改善しえたバッド・キアリ症候群合併透析患者の一例

    若松 拓也, 矢田 雄介, 山本 卓, 中枝 武司, 飯野 則昭, 後藤 眞, 風間 順一郎, 成田 一衛

    日本腎臓学会誌   55 ( 6 )   1045 - 1045   2013年8月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • Cause-specific excess mortality among dialysis patients: Comparison with the general population in Japan 査読

    Minako Wakasugi, Junichiro James Kazama, Suguru Yamamoto, Kazuko Kawamura, Ichiei Narita

    Therapeutic Apheresis and Dialysis   17 ( 3 )   298 - 304   2013年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/j.1744-9987.2012.01144.x

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  • 血液透析患者に合併した進行期胸腺癌に対し全身化学療法を施行した1例

    片桐 隆幸, 三浦 理, 山崎 美穂子, 山本 卓, 坂井 勇仁, 飯野 則昭, 後藤 眞, 各務 博, 風間 順一郎, 成田 一衛

    日本透析医学会雑誌   46 ( Suppl.1 )   547 - 547   2013年5月

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    記述言語:日本語   出版者・発行元:(一社)日本透析医学会  

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  • 新潟県における腹膜透析医療の実際

    飯野 則昭, 山本 卓, 川村 和子, 後藤 眞, 風間 順一郎, 丸山 弘樹, 成田 一衛

    日本透析医学会雑誌   46 ( Suppl.1 )   769 - 769   2013年5月

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    記述言語:日本語   出版者・発行元:(一社)日本透析医学会  

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  • 腹膜透析患者におけるESA切替用量の検討、新潟県内多施設共同研究

    飯野 則昭, 川村 和子, 山本 卓, 後藤 眞, 丸山 弘樹, 風間 順一郎, 成田 一衛

    日本透析医学会雑誌   46 ( Suppl.1 )   913 - 913   2013年5月

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    記述言語:日本語   出版者・発行元:(一社)日本透析医学会  

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  • A combination of healthy lifestyle factors is associated with a decreased incidence of chronic kidney disease: A population-based cohort study 査読

    Minako Wakasugi, Junichiro J. Kazama, Suguru Yamamoto, Kazuko Kawamura, Ichiei Narita

    Hypertension Research   36 ( 4 )   328 - 333   2013年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/hr.2012.186

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  • [Kidney and bone update : the 5-year history and future of CKD-MBD. Treatment for dialysis-related amyloidosis update]. 査読

    Yamamoto S, Kazama JJ, Narita I

    Clinical calcium   22 ( 7 )   1089 - 1098   2012年7月

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    担当区分:筆頭著者, 責任著者  

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  • High Mortality Rate of Infectious Diseases in Dialysis Patients: A Comparison With the General Population in Japan 査読

    Minako Wakasugi, Kazuko Kawamura, Suguru Yamamoto, Junichiro James Kazama, Ichiei Narita

    THERAPEUTIC APHERESIS AND DIALYSIS   16 ( 3 )   226 - 231   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/j.1744-9987.2012.01062.x

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  • Hypogammaglobulinemic Patient with Polyarthritis Mimicking Rheumatoid Arthritis Finally Diagnosed as Septic Arthritis Caused by Mycoplasma hominis 査読

    Hiroe Sato, Noriaki Iino, Riuko Ohashi, Takako Saeki, Tomoyuki Ito, Maki Saito, Yutaka Tsubata, Suguru Yamamoto, Shuichi Murakami, Takeshi Kuroda, Yoshinari Tanabe, Junichi Fujisawa, Takehiro Murai, Masaaki Nakano, Ichiei Narita, Fumitake Gejyo

    INTERNAL MEDICINE   51 ( 4 )   425 - 429   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.51.6058

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  • Nuclear Chromatin-concentrated Osteoblasts in Renal Bone Diseases 査読

    Junichiro James Kazama, Suguru Yamamoto, Ichiei Narita, Satoshi Kurihara

    THERAPEUTIC APHERESIS AND DIALYSIS   15   9 - 13   2011年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/j.1744-9987.2011.00919.x

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  • Cancellous Bone Volume Is an Indicator for Trabecular Bone Connectivity in Dialysis Patients 査読

    Junichiro James Kazama, Ryo Koda, Suguru Yamamoto, Ichiei Narita, Fumitake Gejyo, Akihide Tokumoto

    CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   5 ( 2 )   292 - 298   2010年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2215/CJN.04150609

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  • Comparison of Quantitative Cancellous Bone Connectivity Analyses at Two- and Three-Dimensional Levels in Dialysis Patients 査読

    Junichiro James Kazama, Ryo Koda, Suguru Yamamoto, Ichiei Narita, Fumitake Gejyo, Akihide Tokumoto

    CALCIFIED TISSUE INTERNATIONAL   84 ( 1 )   38 - 44   2009年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00223-008-9194-6

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  • The Risk of Gallbladder Stone Formation Is Increased in Patients with Predialysis Chronic Kidney Disease but Not Those Undergoing Chronic Hemodialysis Therapy 査読

    Junichiro James Kazama, Sakumi Kazama, Ryo Koda, Suguru Yamamoto, Ichiei Narita, Fumitake Gejyo

    NEPHRON CLINICAL PRACTICE   111 ( 3 )   C167 - C172   2009年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000199456

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  • The Risk of Gallbladder Stone Formation Is Increased in Patients with Predialysis Chronic Kidney Disease but Not Those Undergoing Chronic Hemodialysis Therapy 査読

    Suguru Yamamoto

    Nephron Clinical Practice   111 ( 3 )   c167 - 72   2009年

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000199456

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  • Alterations in serum phosphate levels predict the long-term response to intravenous calcitriol therapy in dialysis patients with secondary hyperparathyroidism 査読

    Kiyoko Hosaka, Junichiro James Kazama, Suguru Yamamoto, Yumi Ito, Noriaki Iino, Hiroki Maruyama, Akihiko Saito, Ichiei Narita, Fumitake Gejyo

    JOURNAL OF BONE AND MINERAL METABOLISM   26 ( 2 )   185 - 190   2008年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00774-007-0809-1

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  • [Mechanism of beta(2)-microglobulin-related amyloid fibril formation in CKD]. 査読

    Yamamoto S, Kazama JJ

    Clinical calcium   17 ( 5 )   740 - 744   2007年5月

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    担当区分:筆頭著者, 責任著者  

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  • Circulating osteoprotegerin affects bone metabolism in dialysis patients with mild secondary hyperparathyroidism 査読

    JJ Kazama, K Omori, S Yamamoto, Y Ito, H Maruyama, Narita, I, F Gejyo, Y Iwasaki, M Fukagawa

    THERAPEUTIC APHERESIS AND DIALYSIS   10 ( 3 )   262 - 266   2006年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/j.1744-9987.2006.00375.x

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  • A beta-2M-amyloidosis and related bone diseases 査読

    JJ Kazama, S Yamamoto, N Takahashi, Y Ito, H Maruyama, Narita, I, F Gejyo

    JOURNAL OF BONE AND MINERAL METABOLISM   24 ( 2 )   182 - 184   2006年3月

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  • Pretreatment plasma intact parathyroid hormone and serum calcium levels, but not serum phosphate levels, predict the response to maxacalcitol therapy in dialysis patients with secondary hyperparathyroidism 査読

    Yuko Oyama, Junichiro James Kazama, Kentaro Omori, Noboru Higuchi, Shigemi Kameda, Suguru Yamamoto, Yumi Ito, Hiroki Maruyama, Ichiei Narita, Fumitake Gejyo

    Clinical and Experimental Nephrology   9 ( 2 )   142 - 147   2005年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10157-005-0342-2

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  • Molecular interactions in the formation and deposition of beta(2)-microglobuhn-related amyloid fibrils 査読

    H Naiki, S Yamamoto, K Hasegawa, Yamaguchi, I, Y Goto, F Gejyo

    AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS   12 ( 1 )   15 - 25   2005年3月

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  • Pretreatment serum FGF-23 levels predict the efficacy of calcitriol therapy in dialysis patients 査読

    JJ Kazama, F Sato, K Omori, H Hama, S Yamamoto, H Maruyama, Narita, I, F Gejyo, T Yamashita, S Fukumoto, M Fukagawa

    KIDNEY INTERNATIONAL   67 ( 3 )   1120 - 1125   2005年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/j.1523-1755.2005.00178.x

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  • Direct comparison between two 1-84PTH assays in dialysis patients. 査読

    Kazama JJ, Yamamoto S, Kameda S, Maruyama H, Narita I, Shigematsu T, Gejyo F

    Nephron. Clinical practice   99 ( 1 )   c8 - 12   2005年

  • Direct comparison between two 1-84PTH assays in dialysis patients 査読

    JJ Kazama, S Yamamoto, S Kameda, H Maruyama, Narita, I, T Shigematsu, F Gejyo

    NEPHRON CLINICAL PRACTICE   99 ( 1 )   C8 - C12   2005年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000081788

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  • Glycosaminoglycan and proteoglycan inhibit the depolymerization of beta(2)-microglobulin amyloid fibrils in vitro 査読

    Yamaguchi, I, H Suda, N Tsuzuike, K Seto, M Seki, Y Yamaguchi, K Hasegawa, N Takahashi, S Yamamoto, F Gejyo, H Naiki

    KIDNEY INTERNATIONAL   64 ( 3 )   1080 - 1088   2003年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1046/j.1523-1755.2003.00167.x

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  • Successful perioperative blood purification therapy in patients with maintenance hemodialysis therapy who underwent living donor liver transplantation 査読

    JJ Kazama, N Takahashi, Y Ito, Y Watanabe, N Iino, S Iguchi, A Oyanagi, H Obayashi, S Ito, H Maruyama, Narita, I, S Yamamoto, Y Sato, A Tsuchiya, T Ichida, F Gejyo

    CLINICAL NEPHROLOGY   59 ( 3 )   229 - 233   2003年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Molecular remission induced by fractionated dose-escalating donor leukocyte infusion without graft-versus-host disease in a patient with chronic myelogenous leukemia relapsed after allogeneic bone marrow transplantation

    K Inai, Y Wano, S Yamamoto, Y Ikebata, H Iwasaki, H Tsutani, H Naiki, T Ueda

    ANTICANCER RESEARCH   19 ( 6C )   5631 - 5634   1999年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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▶ 全件表示

MISC

▶ 全件表示

講演・口頭発表等

▶ 全件表示

受賞

  • 平成29年度 日本医師会 医学研究奨励賞

    2017年   日本医師会   蛋白結合尿毒症物質に着目した慢性腎臓病関連疾患のメカニズム解明と治療法の開発 ―尿毒症物質の生成減少と除去向上を目指すー

    山本卓

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  • 平成28年度 新潟県医師会 学術奨励賞

    2016年   新潟県医師会   尿毒症物質に着目した慢性腎臓病関連疾患の病態解明と治療

    山本卓

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  • 平成28年度 日本腎臓学会 大島賞

    2016年   日本腎臓学会   尿毒症物質に着目した慢性腎臓病関連疾患の病態解明と治療

    山本卓

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  • 平成24年度 第16回有壬記念学術奨励賞(基礎医学)

    2012年   新潟大学医学部学士会   1. 腎障害で増悪する動脈硬化病変におけるマクロファージアンギオテンシンII受容体の役割 2. 腎障害で増悪する動脈硬化における経口吸着薬AST-120の改善効果

    山本卓

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  • ベストアブストラクト賞

    2012年   第57回日本透析医学会学術集会・総会   平成24年:透析患者HDLは動脈硬化病変におけるマクロファージの泡沫細胞化を促進する

    山本卓

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共同研究・競争的資金等の研究

  • ウレミックトキシンによるアルブミン機能異常の解析と恒常性を回復する治療法の開発

    研究課題/領域番号:24K11427

    2024年4月 - 2028年3月

    制度名:科学研究費助成事業

    研究種目:基盤研究(C)

    提供機関:日本学術振興会

    山本 卓, 後藤 祐児, 渡邊 博志, 山口 圭一

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    配分額:4550000円 ( 直接経費:3500000円 、 間接経費:1050000円 )

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  • 過飽和蛋白質科学の開拓

    研究課題/領域番号:22H02584

    2022年4月 - 2026年3月

    制度名:科学研究費助成事業

    研究種目:基盤研究(B)

    提供機関:日本学術振興会

    後藤 祐児, 山本 卓, 山口 圭一

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    配分額:17420000円 ( 直接経費:13400000円 、 間接経費:4020000円 )

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  • 新規リン代謝マーカー:ポリリン酸と腎臓病で増悪する感染症の関連

    研究課題/領域番号:20K08628

    2020年4月 - 2024年3月

    制度名:科学研究費助成事業 基盤研究(C)

    研究種目:基盤研究(C)

    提供機関:日本学術振興会

    山本 卓

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    配分額:4420000円 ( 直接経費:3400000円 、 間接経費:1020000円 )

    ポリリン酸が腎臓病患者で増悪する感染症に影響するメカニズムを調査している。免疫細胞とポリリン酸の反応とそれに関わる尿毒症病態について検討した。
    培養細胞マクロファージは少量のリポポリサッカライド(LPS)で炎症性サイトカインの産生を軽微に生じるが、そこにポリリン酸を加えるとその反応が高度に増強された。このポリリン酸の効果は反応させた量と鎖長に依存することが明らかになった。LPSが存在しないとポリリン酸が作用しないため、細胞とLPSの反応におけるポリリン酸の作用点について検討した。その結果、LPSとマクロファージToll-like receptor4との結合をポリリン酸が細胞表面で作用していることが明らかとなった。すなわちポリリン酸はLPSのマクロファージとの反応を細胞表面で促進することで、より炎症反応を増強していることが理解できた。
    腎臓病では多彩なウレミックトキシンが作用し感染症の増悪に寄与している可能性が考えられる。マクロファージにインドキシル硫酸を長期間反応させ、尿毒症状態のマクロファージを作成した。そこにLPSやポリリン酸を反応させるとインドキシル硫酸のない細胞と比較して炎症性サイトカインの発現に違いがみられた。現在、その詳細なメカニズムの解明に取り掛かっている。

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  • 腎性老化現象における粘膜免疫の役割

    研究課題/領域番号:19H03674

    2019年4月 - 2023年3月

    制度名:科学研究費助成事業

    研究種目:基盤研究(B)

    提供機関:日本学術振興会

    成田 一衛, 後藤 眞, 若杉 三奈子, 忰田 亮平, 葭原 明弘, 新藏 礼子, 山本 卓, 金子 佳賢

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    配分額:17030000円 ( 直接経費:13100000円 、 間接経費:3930000円 )

    腎臓病は体液恒常性破綻に加えて加齢現象を進行させ、腎臓病患者では保存期からKlotho遺伝子発現低下、FGF23上昇、カルシウム-リン、ビタミンD代謝異常、血圧上昇、貧血等複数の代謝異常が生じ、サルコペニアや骨粗鬆症、認知機能低下が著しく進行する。この加齢現象は総体的に“腎性老化”として認識されていて、腎臓病発症初期から末期腎不全に至るまでの各段階で、口腔・消化管粘膜細菌叢の変容および自然免疫応答の異常が相互に関連を持ちながら、腎疾患の発症と進行に関与することが分かってきたが、詳細な全体像は不明である。私共は、“腎性老化”現象における粘膜免疫、粘膜における代謝異常の役割を解明し、対策法を開発することを目的とした研究を進めている。IgA腎症患者の扁桃摘出術は腎機能予後や尿蛋白減少などの点で治療効果が確認されているが、その有効性を裏付けるメカニズムが不明である。私共は治療として摘出された口蓋扁桃の細菌叢を網羅的に解析し血清糖鎖不全IgAの産生の原因を解析している。IgA腎症患者に特異的な細菌群が同定されれば、予防と治療に繋がる。私共は16SrRNAシークエンスによるOUTレベル(属レベル)では習慣性扁桃炎と明確な差がないことを過去に報告した(Watanabe H, et al. Nephrol Dial Transpl 2016)。本年度はさらに、口腔内常在菌のうちIgA-seqにより同定された歯周病菌に焦点を当てて、全ゲノムシークエンスを行い扁桃粘膜におけるBリンパ球のレパトワの特異性を報告した(Yamaguchi H, et al. Nephrol Dial Transpl 2021)。並行して行っている臨床研究では透析患者における骨折のリスク因子を解析し、喫煙の影響を明らかにした(Wakasugi M, et al. Nephrol Dial Transpl 2021)。

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  • 慢性腎臓病患者のtrabecular bone scoreによる臨床的骨質評価

    2018年4月

    制度名:腎不全病態研究助成

    提供機関:(公財)日本腎臓財団

    山本卓

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    担当区分:研究代表者  資金種別:競争的資金

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  • 蛋白結合尿毒素物質のHDL機能への作用と治療―腎臓病による動脈硬化を予防する―

    2015年4月 - 2018年3月

    制度名:平成27年度 基盤研究(C)

    提供機関:科学研究費助成事業

    山本卓

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    担当区分:研究代表者  資金種別:競争的資金

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  • ホロゲノム解析によるIgA腎症の病態解析と治療ターゲット探索

    研究課題/領域番号:26293201

    2014年4月 - 2018年3月

    制度名:科学研究費助成事業

    研究種目:基盤研究(B)

    提供機関:日本学術振興会

    成田 一衛, 後藤 眞, 山本 卓, 金子 佳賢, 山本 格, 山口 浩毅, 渡辺 博文, 土田 雅史, 張 高正

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    配分額:16250000円 ( 直接経費:12500000円 、 間接経費:3750000円 )

    IgA腎症の原因解明を目的として、ホストゲノム、摘出口蓋扁桃のメタゲノム、腎生検の糸球体プロテオミクスの3者を同時に解析することにより、粘膜免疫の機能的な異常と疾患プロセスを明らかにすることを試みた。口蓋扁桃においてAPRILが高発現し、扁桃での糖鎖不全IgA(GdIgA1)産生量が腎糸球体における沈着量に相関することを明らかにした。扁桃細菌叢のIgA-Seqを行い、歯周病関連嫌気性桿菌がホストの免疫反応に関与すること、糸球体局所では生合成過程が亢進する一方、上皮細胞の細胞骨格蛋白が減少すること、家系のエクソーム解析により自然免疫や抗原提示能の個人差が発症に影響することが明らかになった。

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  • 蛋白結合尿毒素物質の除去に関する透析器と血液浄化器の効果検討

    2014年4月 - 2015年3月

    制度名:平成26年度 日本透析医会 研究助成

    提供機関:日本透析医会

    山本卓

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    担当区分:研究代表者  資金種別:競争的資金

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  • 経口吸着炭薬による透析患者の蛋白結合尿毒素物質除去と動脈硬化抑制効果

    2014年4月 - 2015年3月

    制度名:第13回循環医学分野一般研究助成

    提供機関:先進医薬研究振興財団

    山本卓

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    担当区分:研究代表者  資金種別:競争的資金

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  • 腎臓病で増悪する動脈硬化病変内マクロファージに対する尿毒素分子の関与と治療対策

    2013年4月 - 2015年3月

    制度名:2013年度 医学系研究奨励

    提供機関:武田科学振興財団

    山本卓

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    担当区分:研究代表者  資金種別:競争的資金

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  • 腎臓病によって増悪する動脈硬化におけるHDLとマクロファージの機能と治療

    2012年4月 - 2014年3月

    制度名:平成24年度 若手研究(B)

    提供機関:科学研究費助成事業

    山本卓

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    担当区分:研究代表者  資金種別:競争的資金

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  • 透析導入に関する予後予測ツールの作成

    2011年4月 - 2012年3月

    制度名:塾生研究助成

    提供機関:iHope-協和発酵キリン

    山本卓

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    担当区分:研究代表者  資金種別:競争的資金

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  • 腎臓病で増悪する動脈硬化病変におけるマクロファージの脂質代謝の解明と治療

    2008年4月 - 2009年3月

    制度名:海外留学助成リサーチフェローシップ

    提供機関:上原記念生命科学財団

    山本卓

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    担当区分:研究代表者  資金種別:競争的資金

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  • 細胞培養下におけるbeta2-ミクログロブリン関連アミロイド線維形成の機序解明

    2007年4月 - 2009年3月

    制度名:平成19年度 若手研究(B)

    提供機関:科学研究費助成事業

    山本卓

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    担当区分:研究代表者  資金種別:競争的資金

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  • 長期透析合併症のゲノミクス・プロテオミクス解析による機序解明

    研究課題/領域番号:19390230

    2007年 - 2008年

    制度名:科学研究費助成事業

    研究種目:基盤研究(B)

    提供機関:日本学術振興会

    風間 順一郎, 成田 一衛, 山本 卓

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    配分額:14690000円 ( 直接経費:11300000円 、 間接経費:3390000円 )

    長期透析に特有な透析アミロイドーシス、腎性骨症、腎性貧血、動脈石灰化などを対象疾患として、疾患とその修飾因子の両サイドから病因検索や治療応答への影響を検索した。本研究によって透析患者長期生存に及ぼす臨床因子が初めて絞り込まれ、またミネラル代謝に及ぼすリンの影響を初めて定量的に示すことなどの成果を得た。また、この過程に作成した約4000人の維持血液透析患者データベースは、期間内の研究結果を導いたのみならず、今後の前向き研究にも有用な足がかりとなった。期間内にこのプロジェクト関係で出版された英語論文19編、国内学会発表9演題、国際学会発表8演題、出版図書7冊。

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  • 透析アミロイドーシスの研究

    2001年 - 2003年

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    資金種別:競争的資金

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担当経験のある授業科目(researchmap)

  • 腎・膠原病内科学

    機関名:新潟大学医歯学総合病院

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  • 血液浄化療法

    機関名:新潟大学医歯学総合病院

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