研究者詳細 - 山本　卓

論文 - 山本　卓

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Oral iptacopan therapy in patients with C3 glomerulopathy: a randomised, double-blind, parallel group, multicentre, placebo-controlled, phase 3 study

David Kavanagh, Andrew S Bomback, Marina Vivarelli, Carla M Nester, Giuseppe Remuzzi, Ming-Hui Zhao, Edwin K S Wong, Yaqin Wang, Induja Krishnan, Imelda Schuhmann, Angelo J Trapani, Nicholas J A Webb, Matthias Meier, Rubeen K Israni, Richard J H Smith, Alejandra Ines Espinosa, Rita Marcela Fortunato, Magali Freijo Freijo, Nadia Fretes, Pablo Miguel Raffaele, Gianna Mastroianni Kirsztajn, Juliana Mansur Siliano, Laila Almeida Viana, Dervla Connaughton, Susan Huang, Faisal Rehman, Pavel Roshanav, Matthew A. Weir, Dong-Yuan Chang, Pei Chen, Bixia Gao, Ying Tan, Li Yang, Xiao-Juan Yu, Xin Zhang, Ming-Hui Zhao, Chuan-Ming Hao, Ling-Yun Lai, Shao-Jun Liu, Eva Jancova, Vladimir Tesar, Anne Blanchard, Sophie Chauvet, Nathalie Chavarot, Roxane Gaisset, François Provôt, Myriam Dao, Hamza Sakhi, Aude Servais, Julia Weinmann-Menke, Ute Eisenberger, Anja Gäckler, Benjamin Wilde, Anne Dieterle, Michael Wiesener, Tobias Huber, Malte Andreas Kluger, Eleftheria-Kleio Dermitzaki, Charikleia Gakiopoulou, Konstantinos Stylianou, Narayan Prasad, Dharmendra Singh Bhadauria, Dinesh Khullar, Soumita Bagchi, Naomi Ben-Dor, Valeria Morduhovich, Benaya Rozen-Zvi, Yael Borovitz, Daniel Landau, Camillo Carrara, Erica Daina, Amantia Imeraj, Maddalena Marasà, Piero Luigi Ruggenenti, Giuseppe Remuzzi, Luca Antonucci, Marcello Chinali, Antonio Gargiulo, Marina Vivarelli, Federica Zotta, Sosuke Fukui, Hangsoo Kim, Masashi Mizuno, Yasuhiro Suzuki, Shin Goto, Michihiro Hosojima, Hideyuki Kabasawa, Yoshikatsu Kaneko, Ryohie Kaseda, Ichiei Narita Narita, Tadashi Otsuka, Hirofumi Watanabe, Suguru Yamamoto, Motoki Matsuki, Naoki Nagakawa, Wataru Ohwada, Arata Osanami, Hidemichi Kouzu, Tomohisa Yamashita, Toshiyuki Yano, Hanneke Bouwsma, Aiko Popke Jan de Vries, Soufiane Meziyerh, Wouter Moest, Dennis A.J. Van den Broek, Y.K. Onno Teng, Teresa Cavero Escribano, Wenceslao Adrian Aguilera Morales, Francisco Jose de la Prada Alvarez, Fabiola Alonso Garcia, Mercedes Salgueira Lazo, Katarina Benackova, Uyen Huynh-Do, Laila-Yasmin Mani, Sibylle Tschumi, Asil Demirezen, Özant Helvaci, Betul Ogut, Saliha Yildirim, David Kavanagh, Edwin K.S. Wong, Tom Cairns, Stephen Paul McAdoo, Liz Lightstone, Nicholas Medjeral-Thomas, Matthew Pickering, Wooin Ahn, Gerald B. Appel, Andrew S. Bomback, Pietro Canetta, Elizabeth Hendren, Allyson Medina, Mariela Navarro-Torress, Jai Radhakrishnan, Jennifer Jetton, Christina Michels, Carla M. Nester, Richard J.H. Smith, James Alan Tumlin

The Lancet 406 ( 10512 ) 1587 - 1598 2025年10月

リチウム長期内服後尿細管の構造変化を伴わずにアクアポリン2の発現低下がみられた腎性尿崩症の一例

鈴木優也, 渡辺博文, 大塚忠司, 蒲澤秀門, 細島康宏, 忰田亮平, 後藤眞, 山本卓

日本腎臓学会誌 67 ( 6-E ) 789 - 789 2025年9月

二次性高血圧症の原因としてのレニン産生卵巣腫瘍

鈴木魁也, 工藤梨沙, 早福あやか, 谷地田希, 南川高廣, 渡辺博文, 忰田亮平, 山本卓, 吉原弘祐

北日本産科婦人科学会総会・学術講演会プログラム・抄録集 72回 133 - 133 2025年9月

MPO-ANCA関連半月体形成性糸球体腎炎にC3腎症様変化を合併した一例

桜沢千尋, 逸見太郎, 渡辺博文, 大塚忠司, 蒲澤秀門, 細島康宏, 伊藤由美, 後藤眞, 山本卓

日本腎臓学会誌 67 ( 6-E ) 785 - 785 2025年9月

Direct Hemoperfusion with Polymethylmethacrylate for Hemodialysis Patients with Dialysis-Related Amyloidosis. 査読国際誌

Shoko Yamazaki, Daisuke Miyauchi, Atsushi Hashimoto, Takahiro Tanaka, Mototsugu Tanaka, Hisaki Shimada, Yuji Ishii, Koji Matsuo, Akio Kasai, Yutaka Koda, Kokichi Saito, Junichi Hoshino, Shinichi Nishi, Suguru Yamamoto

Blood purification 54 ( 11 ) 1 - 10 2025年8月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：S. Karger AG

IntroductionDialysis-related amyloidosis (DRA) is a serious complication in patients undergoing long-term dialysis that leads to conditions such as carpal tunnel syndrome and destructive spondyloarthropathy. Improved removal of the precursor protein β2-microglobulin (β2-m) is considered an effective treatment strategy for DRA. Polymethylmethacrylate (PMMA) membranes have the capacity to adsorb β2-m in dialysis filters, suggesting that direct hemoperfusion with PMMA in addition to standard dialysis may enhance β2-m removal.MethodsThis prospective cohort study included 10 patients undergoing hemodialysis, who were diagnosed with DRA. The participants were treated with dialysis filter alone during Visit 1, both standard dialysis filter and PMMA cartridges (FT-75, volume 75 cm³) during Visits 2–4, and FT-145 PMMA cartridges (volume 145 cm³) during Visits 5–7. The removal rates and clearances of β2-m were quantified. We also assessed the removal of α1-microglobulin (α1-m), matrix metalloproteinase-3 (MMP-3), interleukin-6 (IL-6), and tumor necrosis factor-a (TNF-α), which may be associated with DRA symptoms. ResultsPMMA cartridge had increased β2-m removal rates compared to dialysis filter alone for treatment duration of 240 min. Similarly, the removal rates of α1-m and MMP-3 were higher with PMMA cartridges than with dialysis filter alone. β2-m, α1-m, and MMP-3 clearance improved with the addition of PMMA cartridges, depending on the cartridge size. The removal rates of IL-6 and TNF-α were higher with PMMA cartridges than with dialysis filter alone at 30 min, but not at 240 min .ConclusionDirect hemoperfusion with PMMA is an effective method for removing β2-m in hemodialysis patients with DRA. Beneficial effects were also observed for the removal of α1-m and MMP-3. Further research is required to evaluate the long-term efficacy of this approach in managing DRA.

DOI： 10.1159/000546771

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Genetic and protein structure prediction analyses identify a rare pathogenic PKD1 variant causing autosomal dominant polycystic kidney disease.

Takamitsu Shiiya, Hirofumi Watanabe, Ryo Aida, Tadashi Otsuka, Ryohei Kaseda, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Ichiei Narita

CEN case reports 14 ( 4 ) 612 - 617 2025年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenic kidney disorders. The diagnosis of ADPKD requires imaging findings showing multiple kidney cysts or genetic testing, in cases where a family history is unknown. We report a patient diagnosed with ADPKD based on the identification of a rare PKD1 variant. The patient was a 41-year-old female in whom cysts and calcification in the kidneys were incidentally detected. Whole-exome sequencing identified a rare PKD1 variant (NM_001009944.3: c.11557G > A/p.E3853K). Protein structure prediction of the PKD1-PKD2 complex showed that the variant may be pathogenic, leading to the diagnosis of autosomal dominant polycystic kidney disease. A detailed family history revealed that her relatives also had ADPKD, further supporting the diagnosis of ADPKD. Comprehensive genetic analysis and protein structure prediction led to the diagnosis of ADPKD and the identification of rare causative genes. These methods are useful for diagnosing hereditary kidney diseases of unknown etiologies.

DOI： 10.1007/s13730-025-00985-4

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Tsukamurella conjunctivitidis peritonitis diagnosed by 16S rRNA gene sequencing in a patient undergoing peritoneal dialysis. 査読

Masato Habuka, Kosuke Matsunaga, Asa Ogawa, Takashi Yaguchi, Suguru Yamamoto, Yoshinari Tanabe

CEN case reports 14 ( 4 ) 553 - 557 2025年8月

An end-stage kidney disease patient undergoing dialysis treatment for 50 years with dialysis-related amyloidosis in multiple organs. 査読

Toru Ito, Takashi Kato, Suguru Yamamoto, Hisaki Shimada, Hideyuki Kabasawa, Shin Goto, Riuko Ohashi, Ichiei Narita

CEN case reports 14 ( 4 ) 665 - 673 2025年8月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

Advancements in dialysis treatment have led to an increase in the number of patients undergoing long-term dialysis. These patients often experience a decline in activities of daily living (ADL) owing to various chronic kidney disease-related conditions such as mineral and bone disorders, dialysis-related amyloidosis (DRA), and cardiovascular diseases. A male patient began hemodialysis at the age of 22 years because of end-stage kidney disease caused by chronic glomerulonephritis and continued dialysis treatment for 50 years. The patient died at 72 years of age from sepsis, ischemic colitis, and pneumonia. During the course of treatment, the patient frequently underwent surgeries for carpal tunnel syndrome and destructive spondyloarthropathy, which led to a decline in ADL. An autopsy revealed β2-microglobulin amyloid deposits in multiple organs, including the heart, lungs, and intestines. Long-term dialysis treatment results in ADL impairment owing to osteoarticular disorders caused by DRA, and systemic organ deposits are potentially related to organ failures such as ischemic colitis and pneumonia. Elucidating the pathophysiology of DRA and developing more effective treatments may improve ADL and prognosis in patients undergoing long-term dialysis.

DOI： 10.1007/s13730-025-01003-3

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長期に治療を受けているSLE患者の脆弱性骨折は骨密度よりSLE疾患活動性や感染症入院が関連する

佐藤弘恵, 近藤直樹, 渡井友也, 坂井俊介, 長谷川絵理子, 若松彩子, 野澤由貴子, 小林大介, 黒田毅, 山本卓

日本骨粗鬆症学会雑誌 11 ( Suppl.1 ) 357 - 357 2025年8月

Diospyrobezoar (Persimmon Bezoar)-Induced Intestinal Obstruction in an Older Patient: A Case Report. 査読国際誌

Masato Habuka, Moeri Yamagiwa, Masataka Yonezawa, Asa Ogawa, Suguru Yamamoto

Cureus 17 ( 7 ) e87850 2025年7月

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）

Diospyrobezoar is a bezoar caused by excessive persimmon (Diospyros kaki) consumption, typically occurring in individuals with risk factors such as a history of gastric surgery, diabetes, or advanced age. We report the case of a 93-year-old man who presented with anorexia, nausea, and vomiting. Computed tomography revealed a bezoar-induced obstruction in the proximal jejunum. Despite initial management with Coca-Cola (The Coca-Cola Company, Atlanta, Georgia, United States) lavage and endoscopic fragmentation, surgical intervention was required because of persistent symptoms and intestinal ulceration. A 5 × 5-cm mass composed of >98% tannin was removed, confirming the presence of a diospyrobezoar. Further history assessment revealed that the patient consumed two persimmons daily. The patient recovered uneventfully after surgery and was discharged with dietary guidance. The present case highlights the importance of identifying diospyrobezoar-induced intestinal obstruction in older persimmon consumers, even in the absence of common risk factors, such as prior gastric surgery or diabetes. Early diagnosis based on imaging findings and dietary history, followed by timely surgical treatment, is essential to prevent the development of severe complications. Moreover, educating patients about the risks of excessive persimmon consumption is essential to prevent this condition.

DOI： 10.7759/cureus.87850

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Impact of Dialysis Duration and Frailty on Frailty Progression: A Japanese Nationwide Cohort Study

Kakuya Niihata, Noriaki Kurita, Ryohei Inanaga, Tatsunori Toida, Masanori Abe, Takao Masaki, Suguru Yamamoto

2025年6月

常染色体顕性Alport症候群と遺伝性心筋緻密化障害の合併例の遺伝子解析による原因変異の同定

相田涼, 渡辺博文, 椎谷貴光, 大塚忠司, 忰田亮平, 金子佳賢, 後藤眞, 山本卓

日本腎臓学会誌 67 ( 4 ) 510 - 510 2025年6月

長期レニン-アンジオテンシン系阻害による腎輸入細動脈肥厚と腎障害に対するネプリライシン阻害の保護効果

椎谷貴光, 渡辺博文, 相田涼, 大塚忠司, 忰田亮平, 金子佳賢, 後藤眞, 山本卓

日本腎臓学会誌 67 ( 4 ) 489 - 489 2025年6月

近位尿細管特異的蛋白ACSM2の急性腎障害回復過程における機能

渡辺博文, 椎谷貴光, 相田涼, 大塚忠司, 忰田亮平, 金子佳賢, 後藤眞, 山本卓

日本腎臓学会誌 67 ( 4 ) 498 - 498 2025年6月

Polyacrylic acid-polyvinylpyrrolidone complex for achieving hemostasis after hemodialysis: study protocol for an open-label crossover randomized controlled trial (PAA-PVP study). 査読国際誌

Ryohei Terashima, Mototsugu Tanaka, Atsushi Hashimoto, Daiki Omori, Takahiro Tanaka, Haruna Miyazawa, Masahiro Ishizawa, Yoshihiko Tomita, Tomoko Ito, Yoshiyuki Koyama, Kokichi Saito, Suguru Yamamoto, Shin Goto, Ichiei Narita

Trials 26 ( 1 ) 171 - 171 2025年5月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Achieving rapid and secure hemostasis of the vascular access point is important for patients undergoing maintenance hemodialysis (HD). We developed a polyacrylic acid-polyvinylpyrrolidone (PAA-PVP) complex that absorbs moisture such as blood or sterilizing solution, forms a hydrogel, and adheres to the body's surface, thereby exerting a powerful hemostatic effect. This study aims to compare the effect of PAA-PVP complex versus a conventional non-woven fabric pad on hemostasis at the needle puncture vascular access site in patients on HD. METHODS: This open-label crossover randomized controlled trial will include 50 participants who undergo thrice-weekly HD. Participants in whom hemostasis requires more than 10 min by compression using a conventional pad or who have a severe skin problem at the needle puncture vascular access site will be excluded from the study. Participants will be randomized in a 1:1 ratio to receive either the PAA-PVP complex or conventional pads. Three consecutive weekly hemostatic tests will be performed at 11, 9, 7, 5, 3, and 1 min. The study will employ an individual 3+3 design in which participants in whom hemostasis is achieved in all three sessions in a week will be challenged to a shorter time in the three sessions of the next week. Those in whom hemostasis is achieved in two of three sessions will be tested at the same time point in the three sessions of the next week. The study treatment will be terminated if hemostasis is achieved in only one or none of the sessions, and the minimum time with three consecutive successes will be recorded as the hemostasis time. The primary endpoint, the hemostasis time on the arterial side of the vascular access, will be analyzed using mixed-effect models for repeated measures and include the hemostatic technique and group, period, and individual effects as covariates. DISCUSSION: The study will provide evidence on whether the PAA-PVP complex reduces hemostasis time of the vascular access compared to conventional pad in patients on HD. TRIAL REGISTRATION: jRCTs032220597 (Japan Registry of Clinical Trials; registered on January 30, 2023, https://jrct.niph.go.jp/latest-detail/jRCTs032220597 ).

DOI： 10.1186/s13063-025-08877-9

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Ectopic Production of Parathyroid Hormone and Production of Parathyroid Hormone-related Protein in Dedifferentiated Endometrial Carcinoma Induced Severe Hypercalcemia. 査読

Takeru Ogino, Hirofumi Watanabe, Shoko Yamazaki, Megumi Kurosawa, Akiko Kobayashi, Naofumi Imai, Takahiro Taguchi, Hajime Umezu, Ryo Aida, Kazuki Watanabe, Tadashi Otsuka, Hideyuki Kabasawa, Ryohei Kaseda, Suguru Yamamoto, Kosuke Yoshihara, Shin Goto, Ichiei Narita

Internal medicine (Tokyo, Japan) 64 ( 7 ) 1053 - 1059 2025年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

Hypercalcemia is a significant complication in cancer patients, primarily caused by parathyroid hormone-related peptide (PTHrP) and, rarely, by parathyroid hormone (PTH) production from tumors. We report a case of severe hypercalcemia in a woman with uterine cancer who exhibited elevated PTH and PTHrP levels. Surgical intervention revealed dedifferentiated endometrial carcinoma. Postoperatively, PTH and PTHrP levels normalized but subsequently increased due to metastases. A molecular analysis confirmed the expression of the PTH gene and protein within the tumor, indicating ectopic PTH production. In diagnosing and treating cancers, it is necessary to consider not only PTHrP production but also ectopic PTH production.

DOI： 10.2169/internalmedicine.3899-24

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Nephrotic syndrome induces the upregulation of cell proliferation-related genes in tubular cells in mice. 査読

Yuya Suzuki, Ryohei Kaseda, Yusuke Nakagawa, Hirofumi Watanabe, Tadashi Otsuka, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Taiji Matsusaka, Ichiei Narita

Clinical and experimental nephrology 29 ( 4 ) 393 - 404 2025年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Abstract

Background

Massive proteinuria, dyslipidemia, and hypoalbuminemia induced by nephrotic syndrome (NS) secondarily affect tubular cells. We conducted an RNA sequencing (RNA-seq) analysis using a mouse model of focal segmental glomerulosclerosis to clarify the impact of NS on tubular cells.

Methods

We used transgenic mice expressing hCD25 in podocytes (Nep25) to induce NS by injecting human CD25-specific immunotoxin (LMB2) at a dose of 0.625 ng/g body weight. Seven days after LMB2 injection, we extracted RNA from the whole kidney and conducted an RNA-seq analysis. Subsequently, we conducted multiple immunostaining and in situ hybridization (ISH) of differentially expressed genes (DEGs) to identify their locations and associated cell types. We also investigated the expression levels of DEGs in an additional mouse model of NS induced by adriamycin.

Results

After NS induction, 562 upregulated and 430 downregulated DEGs were identified using RNA-seq. An enrichment analysis revealed the upregulation of cell proliferation-related genes. We observed significant upregulation of Foxm1, a transcription factor linked to cell proliferation. Immunostaining and ISH showed that various tubular cells expressed Mki67 and Foxm1 during NS development. The adriamycin-induced NS model also demonstrated the upregulation of Mki67 and Foxm1 in tubular cells.

Conclusions

NS induced the upregulation of cell proliferation-related genes in tubular cells without detectable renal dysfunction. Our findings may contribute to understanding the pathological effects of nephrotic syndrome on tubular cells.

DOI： 10.1007/s10157-024-02608-1

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その他リンク： https://link.springer.com/article/10.1007/s10157-024-02608-1/fulltext.html

Author's Reply to the Letter to the Editor: Is the "Nutritional Risk Index for Japanese Hemodialysis" Validated as a Nutritional and Prognostic Indicator? 国際誌

Katsuhito Mori, Yosuke Yamamoto, Norio Hanafusa, Suguru Yamamoto, Shingo Fukuma, Yoshihiro Onishi, Masanori Emoto, Masaaki Inaba

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 35 ( 2 ) 370 - 372 2025年3月

A case of multiorgan failure due to carbamazepine intoxication successfully treated with multimodal blood purification therapy. 査読

Chihiro Sakurazawa, Masato Habuka, Yoshifumi Hoshino, Yuichi Sakamaki, Asa Ogawa, Suguru Yamamoto, Hidenori Kinoshita, Ichiei Narita

CEN case reports 14 ( 1 ) 29 - 33 2025年2月

A case of a cerebellar form of progressive multifocal leukoencephalopathy in a patient undergoing peritoneal dialysis. 査読

Yu Waraya, Masato Habuka, Chihiro Sakurazawa, Yuichi Sakamaki, Asa Ogawa, Junsuke Shimbo, Kazuo Nakamichi, Suguru Yamamoto, Ichiei Narita

CEN case reports 14 ( 1 ) 6 - 10 2025年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

Progressive multifocal leukoencephalopathy (PML), a severe demyelinating disease of the central nervous system, is caused by the reactivation of the polyomavirus JC virus (JCV). It favors the cerebrum and typically occurs in patients with immunodeficiencies, with a progressive course and fatal outcome in the majority of cases. However, the cerebellar form of PML, characterized by isolated posterior fossa lesions, such as those in the cerebellum or brainstem at disease onset, is rare, and reports of its occurrence in peritoneal dialysis (PD) patients are lacking. In this paper, we describe a rare case of a cerebellar form of PML in a PD patient. A 64-year-old man undergoing PD was referred to our hospital for anorexia, nausea, and vomiting in the past month. He had finger-to-nose test abnormalities, gaze-directed nystagmus, and scanning speech. He was diagnosed with the cerebellar form of PML based on his progressive cerebellar symptoms, the typical magnetic resonance imaging findings, and the presence of JCV-DNA in the cerebrospinal fluid polymerase chain reaction test. He developed nocturnal delirium, aggravated disquiet, and died of pneumonia on the 69th day. Clinicians should consider the cerebellar form of PML as a differential diagnosis if PD patients develop progressive cerebellar symptoms.

DOI： 10.1007/s13730-024-00896-w

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