Faculty Profiles - SONE, Hirohito

Papers - SONE, Hirohito

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Analysis of the Japanese gestational diabetes mellitus diagnostic strategy during the coronavirus disease 2019 pandemic using DREAMBee study data

Yoshifumi Kasuga, Kei Miyakoshi, Maki Yokoyama, Noriyuki Iwama, Raishi Ichikawa, Hiroshi Yamashita, Ichiro Yasuhi, Asami Ito, Hirohito Sone, Atsuko Abiko, Shinichi Harashima, Maki Kawasaki, Naoko Arata, Shiori Sato, Yuko Iimura, Masako Waguri, Haruna Kawaguchi, Naoki Masaoka, Yoshiyuki Nakajima, Yuji Hiramatsu, Takashi Sugiyama

Journal of Diabetes Investigation 2025.6

Association of bodyweight loss with changes in lipids, blood pressure, and fasting serum glucose following tirzepatide treatment in Japanese participants with type 2 diabetes: A post hoc analysis of the SURPASS J‐mono trial

Hanaka Mimura, Tomonori Oura, Rina Chin, Masakazu Takeuchi, Kazuya Fujihara, Hirohito Sone

Journal of Diabetes Investigation 2025.5

Japan Diabetes Complications Study: Revisiting one of the first large‐scale clinical studies in East Asians with diabetes

Hirohito Sone, Chika Horikawa, Sachiko Tanaka‐Mizuno, Ryo Kawasaki, Kazuya Fujihara, Tatsumi Moriya, Atsushi Araki, Shiro Tanaka, Yasuo Akanuma

Journal of Diabetes Investigation 2025.3

Periodontitis and Mild Cognitive Impairment Risk in Diabetic Patients: Insights from an Exploratory Analysis

Aulia Ramadhani, Kumiko Minagawa, Sachiko Takehara, Noboru Kaneko, Takaho Yamada, Masaru Kitazawa, Hirohito Sone, Yusran Ady Fitrah, Kaname Nohno, Hiroshi Ogawa

Dentistry Journal 2025.11

Combating the Problems of the Necessity of Continuous Learning in Medical Datasets of Type 2 Diabetes

Jenny Price, Tatsuya Yamazaki, Kazuya Fujihara, Hirohito Sone

Engineering Proceedings 2025.9

Demographic and Dietary Determinants of the Association between Dietary Fiber Intake and Obesity in Japanese Adults with Type 2 Diabetes: A Cross-Sectional Study (JDDM 78). International journal

Efrem d'Ávila Ferreira, Mariko Hatta, Laymon Khin, Izumi Ikeda, Mizuki Takeuchi, Yasunaga Takeda, Sakiko Yoshizawa Morikawa, Chika Horikawa, Noriko Kato, Hiroshi Maegawa, Kazuya Fujihara, Hirohito Sone

Public health nutrition 1 - 20 2025.2

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To evaluate the association between dietary fiber intake and obesity in Japanese outpatients with type 2 diabetes, as well as the demographic and dietary factors influencing this association. DESIGN: Cross-sectional study with nationwide registry data on Japanese type 2 diabetes outpatients (2014-2019). Diet was self-reported via a Food Frequency Questionnaire. Obesity was defined as BMI ≥25 kg/m2. SETTING: Clinics throughout Japan. PARTICIPANTS: 1,565 Japanese outpatients with type 2 diabetes (63.1% men; age range 30-89 years). RESULTS: Multivariate analysis revealed that a higher dietary fiber intake was associated with a lower risk of obesity in all participants (95% CI = 0.439-0.795, p < 0.001). Stratified analysis showed a significant inverse association between fiber intake and obesity in men and the older age groups (59-89 years), but not in women or the younger age group (30-58 years). In men, higher fiber intake was associated with healthier lifestyle behaviors, including increased physical activity (p < 0.001) and non-smoking (p < 0.001), with stronger associations compared to women. Vegetables, fruits, and soybeans/soy products were strongly correlated with fiber, while grains had a weak correlation. Folate was the micronutrient most strongly correlated with fiber. CONCLUSION: Higher fiber intake was associated with lower obesity risk, particularly in men and older age groups. These findings emphasize the need for targeted public health initiatives promoting the intake of diverse fiber-rich foods to effectively manage obesity. Further research is needed to understand sex- and age-specific factors in the fiber-obesity relationship in diverse populations.

DOI： 10.1017/S136898002500014X

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Positive association of large alcohol intake per occasion with vision-threatening severe diabetic retinopathy or diabetic macular edema in Japanese men with type 2 diabetes. International journal

Masahiko Yamamoto, Kazuya Fujihara, Hiruma Hasebe, Yuta Yaguchi, Takaho Yamada, Satoru Kodama, Shiro Tanaka, Hirohito Sone

Preventive medicine 191 108220 - 108220 2025.2

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Differing from the overall consumption of alcohol, whether consuming large quantities of alcohol per drinking occasion is associated with higher risk of developing severe diabetic retinopathy remains unknown. METHODS: We examined whether the quantity per drinking occasion (QPO), including a large QPO, and the combinations of the frequency of alcohol consumption (FAC) and QPO were associated with higher risk of developing severe diabetic retinopathy or diabetic macular edema (DME) using adjusted Cox models. Severe diabetic retinopathy or DME was designated as a vision-threatening treatment-required diabetic eye disease (TRDED). For each man with type 2 diabetes who participated in this longitudinal retrospective cohort study, the date of the earliest health check-up during the inclusion period (April 2008 to August 2016) was set as the start date of follow-up. RESULTS: A TRDED was observed in 425 of 21,392 Japanese men aged 22-74 years with type 2 diabetes during a mean follow-up of 4.3 years (4.6/1000 person-years). Multivariable Cox analysis showed that a large QPO, defined as drinking three drinks or more per occasion, in low- (hazard ratio [HR], 4.76; 95 % CI, 2.06-10.97), intermediate- (HR, 1.58; 95 %CI, 1.001-2.50), and high-frequency categories (HR, 2.01; 95 % CI, 1.20-3.36) was significantly associated with elevated risks of TRDED. CONCLUSIONS: In addition to the total amount of ethanol, these findings imply the necessity of avoiding the consumption of large amounts of alcohol on a single occasion to prevent severe diabetic retinopathy or DME.

DOI： 10.1016/j.ypmed.2025.108220

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Cross-sectional and Longitudinal Associations Between Family History of Type 2 Diabetes Mellitus, Hypertension, and Dyslipidemia and Their Prevalence and Incidence: Toranomon Hospital Health Management Center Study (TOPICS24). International journal

Izumi Ikeda, Risa Igarashi, Kazuya Fujihara, Yasunaga Takeda, Efrem d'Ávila Ferreira, Khin Lay Mon, Satoru Kodama, Yasumichi Mori, Takashi Kadowaki, Ritsuko Honda, Yasuji Arase, Hirohito Sone

Mayo Clinic proceedings 2025.1

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To examine the association between a positive family history (parents, siblings, and grandparents) of type 2 diabetes mellitus (T2DM), hypertension, and dyslipidemia and their prevalence and incidence in the same population. PATIENTS AND METHODS: Data on 41,361 participants who underwent health examinations between January 1, 1997, and December 31, 2007, were analyzed, and the results of logistic and Cox regression analyses in the same cohort were examined. RESULTS: Cross-sectional analyses showed that the prevalence of all three diseases increased with a positive family history, especially T2DM, with an odds ratio (OR) of 12.00 (95% CI, 7.82 to 18.41) when the number of affected relatives was greater than or equal to 3 with an OR of 20.43 (95% CI, 11.0 to 37.8) for a positive family history across three generations compared with no family history. However, redefining family history from "parents, siblings, and grandparents" to "parents and siblings" or "parents only" did not significantly change ORs for each disease. Among those with a positive family history and body mass index greater than or equal to 30.0 kg/m2 hypertension was 19 times more prevalent compared with no family history and body mass index of 18.5 to 24.9 kg/m2. In the longitudinal study, family history strongly influenced incident T2DM (hazard ratio[HR], 2.40; 95% CI, 1.93 to 2.98), hypertension (HR, 1.43; 95% CI, 1.26 to 1.62), and dyslipidemia (HR, 1.41; 95% CI, 1.08 to 1.83), respectively. CONCLUSION: Obtaining a family history of these diseases was useful in identifying high-risk groups. Also, for T2DM, the influence of a positive family history was strongest with a marked increase in risk with overlap of affected family members, suggesting that a family history is useful for early detection and prevention.

DOI： 10.1016/j.mayocp.2024.10.020

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Impact of diabetes remission or progression on the incidence of cardiovascular disease in Japan: historical cohort study using a nationwide claims database. International journal

Chihiro Shimayama, Kazuya Fujihara, Laymon Khin, Hiroki Takizawa, Chika Horikawa, Takaaki Sato, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Hirohito Sone

Cardiovascular diabetology 24 ( 1 ) 37 - 37 2025.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Previous studies demonstrated that diabetes remission can occur during intensive intervention and in real-world settings. However, the impact of diabetes remission in real-world settings on the incidence of cardiovascular disease (CVD) remains unclear. METHODS: This retrospective cohort study included 299,967 individuals aged 20-72 years who underwent multiple checkups between 2008 and 2020 and completed ≥ 3 years of follow-up. Patients were divided into four groups according to changes in glycated hemoglobin levels and the use of diabetes medications during the 1-year baseline period: diabetes mellitus (DM)+/no remission, DM+/remission, DM-/no progression, and DM-/progression. The risk of CVD was evaluated using multivariable Cox regression analysis. RESULTS: The median follow-up period was 5.0 years. The rates of CVD in the DM+/no remission, DM+/remission, DM-/no progression, and DM-/progression groups were 7.96, 4.76, 1.99, and 5.47 per 1000 person-years, respectively. Compared with DM+/no remission, DM+/remission reduced the risk of CVD [hazard ratio (HR) = 0.71, 95% confidence interval (CI) = 0.57-0.89]. Meanwhile, the HR for CVD in the DM+/remission group was 0.75 (95% CI = 0.56-0.99) for change in BMI ≤ 0%, versus 0.66 (95% CI = 0.45-0.96) for change in BMI > 0%. CONCLUSIONS: In a real-world setting without intensive intervention, diabetes remission decreased the risk of CVD by approximately 30% regardless of changes in BMI, suggesting that diabetes remission can prevent CVD without weight loss in routine care and emphasizing the importance of achieving remission.

DOI： 10.1186/s12933-025-02578-y

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Association of changes in the type 2 diabetes and MASLD/related SLD status with risk of developing cardiovascular disease. International journal

Yasuhiro Matsubayashi, Kazuya Fujihara, Laymon Khin, Efrem d'Àvila Ferreira, Shizuka Takabayashi, Yuko Yamashita, Takaho Yamada, Satoru Kodama, Hirohito Sone

Diabetes, obesity & metabolism 2025.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND & AIMS: This study assessed the association of remission of type 2 diabetes mellitus (DM) or metabolic dysfunction-associated steatotic liver disease (MASLD)/related SLD (r-SLD; MASLD with excessive alcohol intake) as defined by the fatty liver index with the risk of cardiovascular disease (CVD). METHODS: Health examination data at baseline and after 2 years (2-Years) were extracted from a nationwide claims database in Japan. Among participants aged 18-72 years with at least 3 years of follow-up, 9345 participants with DM-associated MASLD/r-SLD and 71 932 participants with non-DM MASLD/r-SLD at baseline were included in the study. The participants were stratified by the achievement of remission of MASLD/r-SLD or DM at 2-Years. In each group after stratification, the risk of new-onset CVD during the observation period was analysed using multivariate Cox proportional hazards models. RESULTS: During a median follow-up of 4.9 years (starting from 2-Years), 1368 cases of CVD were observed. The hazard ratio (95% confidence interval) for CVD was 0.50 (0.31-0.80) for participants with remission of DM, 0.65 (0.47-0.91) for participants with remission of MASLD/r-SLD, and 0.34 (0.15-0.77) for participants with remission of both DM and MASLD/r-SLD. Conversely, remission of MASLD/r-SLD was not linked to a reduced risk of CVD in participants with non-DM MASLD/r-SLD. CONCLUSION: The association of MASLD/r-SLD remission with CVD risk differs greatly in the presence and absence of DM. In patients with DM-MASLD/r-SLD, MASLD/r-SLD remission can significantly reduce CVD risk similarly as remission of DM.

DOI： 10.1111/dom.16196

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Dietary potassium intake and its interaction with sodium intake on risk of developing cardiovascular disease in persons with type 2 diabetes: The Japan Diabetes Complication and its Prevention Prospective study (JDCP study 12). International journal

Chika Horikawa, Mitsuyoshi Takahara, Naoto Katakami, Yasunaga Takeda, Mizuki Takeuchi, Kazuya Fujihara, Hiroaki Suzuki, Narihito Yoshioka, Hitoshi Shimano, Jo Satoh, Yasuaki Hayashino, Naoko Tajima, Rimei Nishimura, Yoshimitsu Yamasaki, Hirohito Sone

Diabetes, obesity & metabolism 27 ( 1 ) 394 - 406 2025.1

Language：English Publishing type：Research paper (scientific journal)

AIMS: Many guidelines recommend increases in potassium intake. However, the relationship of dietary potassium intake with incident cardiovascular disease (CVD) has not been examined in those with type 2 diabetes (T2DM), including sodium acting antagonistically with potassium. We investigated these relationships in Japanese patients with T2DM. MATERIALS AND METHODS: The investigation was part of the JDCP study, a nationwide prospective study begun in 2007. Analysed were 1477 persons with T2DM, 40-75 years of age, who completed a brief-type, self-administered Diet History Questionnaire at baseline. Primary outcome was a CVD event during the follow-up median 7 years (3.9-8.1 years). Hazard ratios (HRs) for CVD were estimated by Cox regression adjusted for confounders of daily potassium intake categorized by tertiles. Tertiles of sodium intake were also analysed. RESULTS: Mean daily potassium intake in tertiles was 1877, 2627 and 3532 mg, respectively, and significant associations were not shown between potassium intake and incidence of CVD. When HRs for CVD were stratified for potassium intake in tertiles (reference group, bottom tertile) and sodium intake (reference group, bottom tertile), potassium intake in the bottom tertile and sodium intake in the second and top tertiles were associated with significantly elevated HR for CVD (2.79 [1.02-7.63] and 3.92 [1.30-11.79], respectively). CONCLUSIONS: Low potassium intake in conjunction with high sodium intake was significantly associated with increased incident CVD in persons with T2DM. However, CVD incidence was not related to high potassium intake, regardless of sodium intake.

DOI： 10.1111/dom.16035

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バセドウ病とうつ病を治療中に、破壊性甲状腺炎と悪性カタトニア発症し集学的な治療を要した一例

磯貝真理恵, 高澤遥子, 村井幸四郎, 佐藤隆明, 山本正彦, 北澤勝, 鈴木浩史, 松林泰弘, 藤原和哉, 山田貴穂, 小柴みなみ, 吉永清宏, 江川純, 曽根博仁

日本内分泌学会雑誌 100 ( 4 ) 907 - 907 2024.12

Coronary artery disease risk prediction by combined stratification of low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol levels across different glucose statuses. International journal

Junko Yachida, Kazuya Fujihara, Mayuko Harada Yamada, Ayako Kobayashi, Lay Mon Khin, Hiroki Takizawa, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Satoru Kodama, Hirohito Sone

Diabetes, obesity & metabolism 26 ( 12 ) 5845 - 5856 2024.12

Language：English Publishing type：Research paper (scientific journal)

AIM: To investigate the association between low-density lipoprotein-cholesterol (LDL-C) levels and coronary artery disease (CAD) incidence based on combining high-density lipoprotein-cholesterol (HDL-C) levels and glucose status. MATERIALS AND METHODS: In this retrospective cohort study, we used data from a nationwide claims database (1,524,289 individuals without a history of CAD or familial hypercholesterolaemia; 2008-2019). Cox proportional hazards modelling identified the risk of incident CAD by a novel combination of four HDL-C levels, seven LDL-C levels and glucose status. RESULTS: During the follow-up period (mean: 5.5 years), 8301 (0.99/1000 person-years) events occurred. The risk of CAD increased from lower LDL-C levels accompanied by lower HDL-C levels regardless of the glucose status. Using the most favourable levels of HDL-C and LDL-C (i.e. 60-99 mg/dL and <80 mg/dL, respectively) as references, the hazard ratios (95% confidence interval) for the group with HDL-C levels <40 mg/dL and LDL-C levels <80 mg/dL were 2.74 (1.47-5.11), 2.52 (1.30-4.91) and 2.85 (1.68-4.84) for normoglycaemia, borderline glycaemia and diabetes, respectively. Comparison of the most favourable levels of HDL-C and LDL-C with their least favourable levels (i.e. <40 mg/dL and 180-199 mg/dL, respectively) revealed that the risk of new-onset CAD exhibited a 19-, nine- and seven-fold increase in individuals with normoglycaemia, borderline glycaemia and diabetes, respectively. CONCLUSIONS: To prevent CAD, LDL-C levels should be strictly controlled in patients with low HDL-C levels regardless of glucose tolerance. Individualized treatment, which involves setting target LDL-C levels based on glucose tolerance and HDL-C values, is required.

DOI： 10.1111/dom.15956

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Achieving normoglycaemia with tirzepatide: Post hoc exploratory analysis of the SURPASS J‐mono and J‐combo studies

Kazuya Fujihara, Yasuhiro Matsubayashi, Masaru Kitazawa, Takaaki Sato, Masakazu Takeuchi, Tomonori Oura, Hirohito Sone

Diabetes, Obesity and Metabolism 2024.11

Machine learning algorithms mimicking specialists decision making on initial treatment for people with type 2 diabetes mellitus in Japan diabetes data management study (JDDM76)

Jenny Elizabeth Price, Kazuya Fujihara, Satoru Kodama, Katsuya Yamazaki, Hiroshi Maegawa, Tatsuya Yamazaki, Hirohito Sone

Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2024.11

ラブフィリン3A抗体にて診断を行ったリンパ球性汎下垂体炎の一例

丹野貴文, 佐藤隆明, 木村智佑, 滝澤大輝, 山本正彦, 石黒創, 北澤勝, 鈴木浩史, 松林泰弘, 山田貴穂, 藤原和哉, 藤沢治樹, 鈴木敦詞, 椙村益久, 曽根博仁

日本内分泌学会雑誌 100 ( 2 ) 634 - 634 2024.10

Risk stratification for cardiovascular disease based on prior coronary artery disease, cerebrovascular disease and type 2 diabetes mellitus.

Momoko Oe, Kazuya Fujihara, Mayuko Harada Yamada, Taeko Osawa, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaaki Sato, Yuta Yaguchi, Midori Iwanaga, Takaho Yamada, Hirohito Sone

Journal of diabetes investigation 15 ( 10 ) 1464 - 1471 2024.10

Language：English Publishing type：Research paper (scientific journal)

AIMS/INTRODUCTION: History of coronary artery disease (CAD), cerebrovascular disease (CeVD), type 2 diabetes and their combined effect on cardiovascular disease are essential for cardiovascular risk management. We investigated the association of prior CAD, prior CeVD, type 2 diabetes and their combination with the risk of cardiovascular disease. MATERIALS AND METHODS: This is a historical cohort study including 342,033 participants (aged 18-72 years) followed up for ≥5 years between 2008 and 2016. Participants were classified into eight groups (with or without prior CAD, prior CeVD and type 2 diabetes). Type 2 Diabetes was defined by fasting plasma glucose and glycated hemoglobin levels, and antidiabetic drug prescription. Prior and subsequent CAD and CeVD were identified according to claims using International Classification of Diseases 10th Revision codes, medical procedures and questionnaires. Cox regression models were used to evaluate the risk of cardiovascular events. RESULTS: The median follow-up period was 6.4 years. The incidence of composite cardiovascular events of CAD and CeVD in the CAD-/CeVD-, CAD+/CeVD-, CAD-/CeVD+ and CAD+/CeVD+ groups were 1.92 and 6.94, 25.14 and 31.98 per 1,000 person-years in non-diabetes participants, and 8.66, 18.04, 39.98 and 60.72 in type 2 diabetes patients, respectively. Hazard ratios of cardiovascular events compared with CAD-/CeVD-/non-diabetes were 1.66 (95% confidence interval 1.55-1.78) in CAD-/CeVD-/type 2 diabetes and 1.84 (1.56-2.18) in CAD+/CeVD-/non-diabetes. CeVD+ was linked to a 4-7-fold increase in the risk of cardiovascular events regardless of CAD+ or type 2 diabetes. CONCLUSIONS: Type 2 diabetes increased the risk of cardiovascular disease as high as a history of CAD, whereas prior CeVD alone increased the risk of future CeVD without additional effects by type 2 diabetes.

DOI： 10.1111/jdi.14277

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Healthy lifestyle factors as predictors of the initiation of dialysis in people with and without diabetes.

Taeko Osawa, Kazuya Fujihara, Mayuko Harada Yamada, Yuta Yaguchi, Takaaki Sato, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Satoru Kodama, Hirohito Sone

Diabetology international 15 ( 4 ) 786 - 793 2024.10

Language：English Publishing type：Research paper (scientific journal)

AIMS: To clarify the impact of Breslow's scores consisting of only lifestyle habits or American Heart Association's (AHA) Life's Simple 7 scores consisting of lifestyle habits and control targets on starting dialysis in people with or without diabetes mellitus (DM). METHODS: To pursue the study aims, we examined a nationwide database on 294,647 individuals with and without DM aged 19-72 y in Japan to pursue the study aims. Using multivariate Cox modeling, we evaluated and compared 5 risk factors based on the unfavorable lifestyle factors in Breslow's scores and the unfavorable lifestyle factors and clinical values in AHA Life's Simple 7 scores. RESULTS: DM increased the risk of the initiation of dialysis 5- to sixfold but that risk did not increase with worsening of Breslow risk factors. Compared with no risk factor, 5 risk factors derived from AHA's Life's Simple 7 presented 9.8-fold and 4.2-fold risks for the initiation of dialysis in non-DM and DM, respectively. In comparison with non-DM and no risk factor, risk of the initiation of dialysis dramatically increased up to 32.3 times according to the number of AHA risk factors in those with DM. CONCLUSIONS: DM and risk factors derived from AHA's Life's Simple 7 synergistically increased the risk of the initiation of dialysis. Factors similar to those used to predict cardiovascular disease would also be useful to predict the initiation of dialysis. These approaches might be helpful in clinical practice and patient education. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13340-024-00739-0.

DOI： 10.1007/s13340-024-00739-0

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心血管疾患 2型糖尿病およびMASLDの寛解による心血管疾患(CVD)発症率の変化

松林泰弘, 藤原和哉, 山田万祐子, 佐藤隆明, 山本正彦, 石黒創, 大澤妙子, 北澤勝, 山田貴穂, 曽根博仁

糖尿病合併症 38 ( Suppl.1 ) 143 - 143 2024.9

心血管疾患糖尿病の寛解が心血管疾患発症に及ぼす影響の検討

島山千弥, 藤原和哉, 大江桃子, 上神洋平, 滝澤大輝, 佐藤隆明, 鈴木浩史, 北澤勝, 松林泰弘, 山田貴穂, 児玉暁, 曽根博仁

糖尿病合併症 38 ( Suppl.1 ) 143 - 143 2024.9

網膜症・動脈硬化1 糖尿病・冠動脈疾患・脳血管疾患の既往及び組み合わせがその後の心血管疾患リスクへ及ぼす影響の検討

大江桃子, 藤原和哉, 山田万祐子, 山本正彦, 大澤妙子, 北澤勝, 松林泰弘, 佐藤隆明, 矢口雄大, 山田貴穂, 曽根博仁

糖尿病合併症 38 ( Suppl.1 ) 154 - 154 2024.9

網膜症・動脈硬化2 脳卒中の既往と尿蛋白陽性が重症糖尿病網膜症発症に与える影響についての検討

山本正彦, 藤原和哉, 矢口雄大, 山田万祐子, 佐藤隆明, 鈴木浩史, 松林泰弘, 長谷部日, 山田貴穂, 児玉暁, 田中司朗, 曽根博仁

糖尿病合併症 38 ( Suppl.1 ) 155 - 155 2024.9

日本人健常妊婦における妊娠初期の栄養摂取量と妊娠中の体重増加量および妊娠転帰への影響の検討

谷内洋子, 生魚薫, 堀川千嘉, 森川咲子, 治田麻理子, 曽根博仁

New Diet Therapy 40 ( 2 ) 167 - 167 2024.9

Robust growth hormone responses to GH-releasing peptide 2 in adolescents. International journal

Takanori Onuki, Tadokoro Hiroaki, Kentaro Sawano, Nao Shibata, Hiromi Nyuzuki, Yohei Ogawa, Masayasu Okada, Hirohito Sone, Keisuke Nagasaki

Journal of pediatric endocrinology & metabolism : JPEM 37 ( 8 ) 730 - 733 2024.8

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: GH-releasing peptide-2 (GHRP2) can be used for provocative growth hormone testing (GHT). Since it acts as a powerful stimulus for GH secretion, cut-off peak GH level in GHRP2 loading test (GHRP2T) is higher than in other GHT. Nevertheless, data on response at adolescents are limited. This report aimed to investigate peak GH levels in GHRP2T in adolescents. METHODS: Clinical data of adolescents after onset of puberty who underwent GHRP2T at our institution from May 2010 to March 2023 were collected retrospectively. Subjects were classified into three groups according to underlying diseases. RESULTS: A total of 23 patients were included: 12 in organic or genetic GHD (o/gGHD) group, three in idiopathic GHD (iGHD) group, and eight in short stature (SS) group. The median GH peak levels were 3.4 ng/mL in o/gGHD group, 88.9 ng/mL in iGHD group, and 90.1 ng/mL in SS group, indicating a robust response of GH peak levels in iGHD and SS groups. Two patients exceeded the cut-off for GHRP2T but below for other GHT, indicating the current cut-off for GHRP2T may miss some GHD patients. CONCLUSIONS: The GH response to GHRP2T in adolescents except the o/gGHD group may be robustly responsive. For the correct diagnosis of GHD, the cut-off peak GH levels in GHRP2T in adolescents may require revisiting.

DOI： 10.1515/jpem-2024-0115

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妊娠糖尿病合併妊婦における産後糖代謝異常リスクの検討

山田貴穂, 柳生田紀子, 西島浩二, 小川洋平, 谷内洋子, 吉原弘祐, 曽根博仁

糖尿病と妊娠 24 ( 2 ) S - 106 2024.8

当院における周産期レジストリーを用いた妊娠糖尿病の転帰や予後の検討

柳生田紀子, 山田貴穂, 西島浩二, 有森直子, 小川洋平, 吉原弘祐, 曽根博仁

糖尿病と妊娠 24 ( 2 ) S - 102 2024.8

重度糖尿病により帯状疱疹の全身性播種を来した1例

木村智佑, 間島貴之, 佐藤隆明, 鈴木浩史, 鈴木紗也佳, 佐藤もも, 加勢夕季乃, 河合亨, 松林泰弘, 山田貴穂, 曽根博仁

糖尿病 67 ( 7 ) 288 - 288 2024.7

Impact of health practice index and cardiovascular health metrics on incident cardiovascular disease according to glucose tolerance status.

Koshiro Murai, Kazuya Fujihara, Mayuko Harada Yamada, Yasuhiro Matsubayashi, Takaho Yamada, Midori Iwanaga, Masaru Kitazawa, Masahiko Yamamoto, Taeko Osawa, Yuta Yaguchi, Satoru Kodama, Hirohito Sone

Diabetology international 15 ( 3 ) 456 - 464 2024.7

Language：English Publishing type：Research paper (scientific journal)

AIMS: To evaluate and compare the association of incident cardiovascular disease (CVD) with the Health Practice Index (HPI) reflecting only lifestyle habits and Ideal Cardiovascular Health Metrics (ICVHMs) consisting of lifestyle habits and factors targeted for control in the same population according to glucose status. METHODS: This retrospective cohort study included 1,28,162 participants aged 18-72 years with no history of CVD followed for ≥ 3 years between 2008 and 2016. Participants were classified according to normal glucose tolerance (86,174), prediabetes (36,096), or diabetes (5892). HPI and ICVHMs scores were classified into three groups (high/medium/low). Multivariate Cox regression hazard analysis examined CVD risk. RESULTS: During a mean follow-up of 5.2 years, 1057 CVD events occurred. In prediabetes, CVD risk was significantly higher in groups with both medium and low HPI scores and ICVHMs scores compared to high scores for normal glucose tolerance (hazard ratios [HRs] for high/medium/low HPI scores were 0.95 [0.78-1.17], 1.56 [1.29-1.89], and 2.41 [1.74-3.34] and for ICVHMs scores were 0.74 [0.50-1.11], 1.58 [1.26-1.98], and 2.63 [2.10-3.31], respectively). Regarding diabetes, compared with high HPI/ICVHMs scores in the normal glucose tolerance group, a significantly increased CVD risk was observed in the high-score HPI group, but not in the high-score ICVHMs group (HPI high/medium/low HR, 1.63 [1.22-2.18], 2.19 [1.69-2.83], and 2.26 [1.34 -3.83]; ICVHMs high/medium/low HR, 1.14 [0.47-2.81], 2.38 [1.75-3.23], and 3.31 [2.50-4.38], respectively). CONCLUSIONS: In diabetes, ideal lifestyle practices alone were insufficient for primary prevention of CVD but had a greater impact on primary prevention of CVD in prediabetes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13340-024-00708-7.

DOI： 10.1007/s13340-024-00708-7

PubMed

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1666-P: Effect of Obesity in Family History (FH) on the Prevalence of Type 2 Diabetes Mellitus (T2DM), Hypertension (HT), and Dyslipidemia (DL)

IZUMI IKEDA, KAZUYA FUJIHARA, YASUNAGA TAKEDA, CHIKA HORIKAWA, SATORU KODAMA, EFREM D. FERREIRA, YASUMICHI MORI, TAKASHI KADOWAKI, RITSUKO YAMAMOTO-HONDA, YASUJI ARASE, HIROHITO SONE

Diabetes 73 ( Supplement_1 ) 2024.6

Publishing type：Research paper (scientific journal) Publisher：American Diabetes Association

Heritability and obesity are strongly associated with the prevalence of T2DM, HT, and DL. We compared the effects of an FH of T2DM, HT, and DL combined with obesity on the prevalence of each in the same population. Of 41931 participants who underwent health checkups, the effects of an FH and BMI on the prevalence of those conditions were analyzed cross-sectionally. Prevalences of T2DM, HT, and DL were 5%, 20%, and 48%, respectively. Logistic regression analysis showed that ORs increased for all three as the number of FH positive cases increased and was most pronounced for T2DM. An FH of obesity and increased BMI were additively associated with the prevalence of the three diseases compared to BMI 20.0-21.9 and no positive FH (Fig. A). In addition, the combination of the number of family members with FH positivity (0,1, 2, ≥3) and obesity was additively associated with an increased FH of the three diseases compared to non-obesity and no FH of any of these diseases (Fig. B). For T2DM, the OR increased sharply in non-obese participants when the number of those with an FH of T2DM was ≥3 (14.4 [8.88-23.5]), but in obese participants the OR increased sharply when the number of those with an FH of T2DM was 2 (12.2 [8.85-16.9]) (Fig. B). Results suggest that, especially for T2DM, avoidance of obesity may be effective in reducing the prevalence of these disorders in those with many FH-positive family members.

 Disclosure

I. Ikeda: None. K. Fujihara: None. Y. Takeda: None. C. Horikawa: None. S. Kodama: None. E.D. Ferreira: None. Y. Mori: None. T. Kadowaki: None. R. Yamamoto-Honda: None. Y. Arase: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kowa Company, Ltd., Kyowa Kirin Co., Ltd., Eisai Inc., Sumitomo Dainippon Pharma Co., Ltd.

DOI： 10.2337/db24-1666-p

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1148-P: Trajectories of Abnormalities in Metabolic Parameters in Japanese Adolescents and Young Adults

IZUMI IKEDA, KAZUYA FUJIHARA, HARUKA SHIOZAKI, SAKIKO Y. MORIKAWA, CHIKA HORIKAWA, YASUNAGA TAKEDA, HAJIME ISHIGURO, TAKAHO YAMADA, SATORU KODAMA, YOHEI OGAWA, HIROHITO SONE

Diabetes 73 ( Supplement_1 ) 2024.6

Publishing type：Research paper (scientific journal) Publisher：American Diabetes Association

Childhood obesity mostly transitions into adulthood and leads to non-communicable diseases such as type 2 diabetes and metabolic syndrome. We aimed to examine individual-level transitions in metabolic parameters during adolescence and young adulthood. We analyzed metabolic parameters in 523 participants (311 males) who underwent health examinations at the ages of 14 y (8th grade) and 20 y. Weight status was assessed by the International Obesity Task Force at 14 y and by BMI (thinness: &lt;18.5; normal: 18.5-24.9; obesity: ≥25.0) at 20 y. HbA1c ≥5.7% was defined as high. Clustered metabolic risk score (CMR) was calculated by summing the sex-age specific Z-scores of each metabolic factor (mean arterial pressure, non-HDLC, and HbA1c) with ≥1 SD defined as high. Among participants who were obese at 14 y, 56% of males and 29% of females remained obese at 20 y. In both sexes, 30-50% had high HbA1c and 30-50% had high CMR as tracked from adolescence to adulthood (table). Furthermore, the high CMR of obese females increased markedly from about 20% at 14 y to 50% at 20 y. In addition, 60% of females who were obese at both 14 y and 20 y had high HbA1c at 20 y. Results suggested the importance of lifestyle interventions from childhood, as about half of the high metabolic parameters observed in adolescents were tracked into adulthood, and obesity complications, which were rarely shown at 14 y, appeared in many at age 20 y.

 Disclosure

I. Ikeda: None. K. Fujihara: None. H. Shiozaki: None. S.Y. Morikawa: None. C. Horikawa: None. Y. Takeda: None. H. Ishiguro: None. T. Yamada: None. S. Kodama: None. Y. Ogawa: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kowa Company, Ltd., Kyowa Kirin Co., Ltd., Eisai Inc., Sumitomo Dainippon Pharma Co., Ltd.

DOI： 10.2337/db24-1148-p

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1264-P: Impacts of Diabetes (DM) on Severe Functional Disability (FD) and Care-Need Level Deterioration in Japanese

IZUMI IKEDA, KAZUYA FUJIHARA, HARUKA SHIOZAKI, SAKIKO Y. MORIKAWA, KAHORI TSURUOKA, YAMASHITA YUKO, LAY MON KHIN, SIJIA WU, NORIKO YAGYUDA, CHIKA HORIKAWA, HIROHITO SONE

Diabetes 73 ( Supplement_1 ) 2024.6

Publishing type：Research paper (scientific journal) Publisher：American Diabetes Association

Avoidance of FD and the deterioration of care level needs leading to a decline in ADL and increased medical costs is urgent. We aimed to clarify the association between lifestyle habits, non-communicable diseases (i.e., DM, HT, and dyslipidemia) and their combinations and the incidence of severe FD and deterioration of the care-level. Followed for a median of 3.7 years were 9673 people who underwent health checkups. Care-level ≥2 (total assistance needed) indicates severe FD and worsening from the initial examination indicates deterioration. During the study period, 111 cases of severe FD occurred. Multivariate analysis showed that aging (per 5y) (OR 2.24 [1.95-2.56]), male (1.76 [1.16-2.66]), BMI&lt;18.5 (2.46 [1.40-4.35]), DM (1.81 [1.06-3.08]), HT (1.58 [1.05-2.38]), and lack of physical activity (PA) (2.17 [1.37-3.45]) were associated with severe FD. Prevalence of DM additively associated with severe FD. DM and ≥2 risk factors had a 10 times greater association than non-DM and no risk factor. Of 85 cases with worsening care needs, only DM was significantly associated with deterioration (2.88 [1.08-7.65]). DM is a significant risk factor for with double the increased risk of severe FD and triple care-need deterioration compared with those without DM. Also, in DM patients, low BMI, HT, and lack of PA greatly increased the risk of severe FD, suggesting the need for comprehensive treatment strategies.

 Disclosure

I. Ikeda: None. K. Fujihara: None. H. Shiozaki: None. S.Y. Morikawa: None. K. Tsuruoka: None. Y. Yuko: None. L. Khin: None. S. Wu: None. N. Yagyuda: None. C. Horikawa: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kowa Company, Ltd., Kyowa Kirin Co., Ltd., Eisai Inc., Sumitomo Dainippon Pharma Co., Ltd.

DOI： 10.2337/db24-1264-p

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1372-P: Association between Fat Intake as the Percent of Total Energy and Incidence of Cardiovascular Disease in Persons with Type 2 Diabetes—Japan Diabetes Complication and Its Prevention Prospective Study (JDCP Study)

CHIKA HORIKAWA, MITSUYOSHI TAKAHARA, NAOTO KATAKAMI, YASUNAGA TAKEDA, MIZUKI TAKEUCHI, KAZUYA FUJIHARA, HIROAKI SUZUKI, NARIHITO YOSHIOKA, HITOSHI SHIMANO, JO SATOH, YASUAKI HAYASHINO, NAOKO TAJIMA, RIMEI NISHIMURA, YOSHIMITSU YAMASAKI, HIROHITO SONE

Diabetes 73 ( Supplement_1 ) 2024.6

Publishing type：Research paper (scientific journal) Publisher：American Diabetes Association

Previous systematic reviews showed benefits of low-carbohydrate eating plans compared with low-fat eating plans in the treatment of diabetes (T2D) on parameters of cardiovascular disease (CVD) risk. However, studies on the relationship between fat intake as the % of total energy (F%E) and incidence of CVD in persons with T2D are insufficient. Therefore, we investigated this relationship as part of the JDCP study, a nationwide study launched in 2007. A total of 1477 persons with T2D aged 40-75 years completed a brief self-administered Diet History Questionnaire at baseline, and we analyzed the resultant data. Primary outcome was the 7-year risk of a CVD event. Hazard ratios for CVD according to quartiles of F%E (Q1-4) were estimated by Cox regression adjusted for confounders including sex, age, various laboratory tests, medication use, smoking history, drinking habits, physical activity, energy intake, protein intake, dietary fiber intake, and sodium intake. Mean F%E in Q1 to Q4 were 16.6%E, 21.8%E, 25.4%E, and 30.9%E, respectively. HbA1c, body mass index, triglycerides, and blood pressure were well controlled. No significant associations between F%E and incidence of CVD were shown for Q2, Q3, and Q4 relative to Q1 (Q2: 1.03 [95% CI, 0.47-2.28], Q3: 1.27 [0.58-2.76], and Q4: 1.10 [0.44-2.73]). Stratified analysis by sex and age also showed no significant difference between F%E and incidence of CVD. When %E from saturated fatty acids (SFA%E) was analyzed according to quartiles 1 and 4 SFA%E values were 4.9%E and 7.1%E, respectively. There were no significant differences in incidence of CVD among quartiles (Q1: Reference, Q2: 1.31 [0.66-2.61], Q3: 0.47 [0.18-1.25], and Q4: 1.02 [0.44-2.39]). Findings suggested that most Japanese with T2D during the study period consumed &lt; 30% of F%E and &lt;10% of SFA%E. No significant differences in incident CVD were observed within these ranges.

Disclosure

C. Horikawa: None. M. Takahara: None. N. Katakami: Speaker's Bureau; Abbott Japan Co., Ltd., Kowa Company, Ltd., MSD, Mitsubishi Tanabe Pharma Corporation, Lilly Diabetes, Ono Pharmaceutical Co., Ltd., Sumitomo Dainippon Pharma Co., Ltd., Teijin Pharma Limited, Kyowa Kirin Co., Ltd., Daiichi Sankyo, Boehringer-Ingelheim, Sanofi. Y. Takeda: None. M. Takeuchi: None. K. Fujihara: None. H. Suzuki: Speaker's Bureau; Abbott Japan Co., Ltd., Sumitomo Dainippon Pharma Co., Ltd., Novo Nordisk, Kissei Pharmaceutical Co., Ltd., Kowa Company, Ltd., Boehringer-Ingelheim, Terumo Corporation, AstraZeneca, Bayer Inc., Kyowa Kirin Co., Ltd. N. Yoshioka: None. H. Shimano: None. J. Satoh: Speaker's Bureau; Lilly Diabetes, Merck & Co., Inc., Ono Pharmaceutical Co., Ltd., Sanofi, Sumitomo Dainippon Pharma Co., Ltd., Boehringer-Ingelheim. Y. Hayashino: Speaker's Bureau; Eli Lilly and Company, Merck & Co., Inc., Boehringer-Ingelheim, Sanofi, Sumitomo Dainippon Pharma Co., Ltd., Novo Nordisk A/S. N. Tajima: None. R. Nishimura: Speaker's Bureau; Abbott. Advisory Panel; Abbott Japan Co., Ltd. Speaker's Bureau; Boehringer-Ingelheim, Mitsubishi Tanabe Pharma Corporation, Kowa Company, Ltd., Medtronic, Sanofi, Taiho Pharmaceutical Co. Ltd., Sumitomo Dainippon Pharma Co., Ltd., Teijin Pharma Limited, Eli Lilly and Company, Novo Nordisk A/S. Consultant; Terumo Corporation. Y. Yamasaki: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kowa Company, Ltd., Kyowa Kirin Co., Ltd., Eisai Inc., Sumitomo Dainippon Pharma Co., Ltd.

Funding

The Japan Diabetes Society, the Japan Society for the Promotion of Science(23K10873).

DOI： 10.2337/db24-1372-p

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1474-P: Cross-Sectional and Longitudinal Relationships between Detailed Family History (FH) of Type 2 Diabetes Mellitus (T2DM), Hypertension (HT), and Dyslipidemia (DL) and Prevalence of Each Disorder

IZUMI IKEDA, KAZUYA FUJIHARA, YASUNAGA TAKEDA, MARIKO HATTA, SIJIA WU, SATORU KODAMA, YASUMICHI MORI, TAKASHI KADOWAKI, RITSUKO YAMAMOTO-HONDA, YASUJI ARASE, HIROHITO SONE

Diabetes 73 ( Supplement_1 ) 2024.6

Publishing type：Research paper (scientific journal) Publisher：American Diabetes Association

A FH of T2DM, HT, and DL are known risk factors; however, few studies have compared the impact of a FH of the 3 diseases in the same population. We examined the impact of a detailed FH of these conditions (i.e., in fathers, mothers, siblings and grandparents) on their prevalence and incidence in the study population. Data on 41,931 participants who underwent health checkups were examined and the results of a logistic regression and (Cox regression model in the same cohort were examined. Results of the cross-sectional study showed that odds ratios increased with the degree of a positive FH for all three diseases. Furthermore, in T2DM, the group with a three-generation positive FH was approximately 20 times larger than the control group which had no FH (Figure). In the longitudinal study, FH had a strong influence on the incidence of T2DM, HT, and DL, in that order, with a hazard ratio of 2.40 (1.93-2.98) for T2DM. A detailed FH was extremely useful for both quantitative screening for each disease and predicting the incidence of the three diseases, especially T2DM, for which a high risk was indicated in multiple generations with overlapping of positivity for a particular disease.

 Disclosure

I. Ikeda: None. K. Fujihara: None. Y. Takeda: None. M. Hatta: None. S. Wu: None. S. Kodama: None. Y. Mori: None. T. Kadowaki: None. R. Yamamoto-Honda: None. Y. Arase: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kowa Company, Ltd., Kyowa Kirin Co., Ltd., Eisai Inc., Sumitomo Dainippon Pharma Co., Ltd.

DOI： 10.2337/db24-1474-p

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1259-P: Relationship between Number of Multiple Risk Factors and Functional Disability (FD) in Those With and Without Diabetes Mellitus (DM)

HARUKA SHIOZAKI, KAZUYA FUJIHARA, KAHORI TSURUOKA, IZUMI IKEDA, MASARU KITAZAWA, YASUHIRO MATSUBAYASHI, MASAHIKO YAMAMOTO, TAKAHO YAMADA, SATORU KODAMA, HIROHITO SONE

Diabetes 73 ( Supplement_1 ) 2024.6

Publishing type：Research paper (scientific journal) Publisher：American Diabetes Association

Although control of multiple risk factors is essential to prevent FD with and without DM, longitudinal studies are scarce that directly and quantitatively compare effects of such control. Thus, we assessed whether reaching multifactorial targets for HbA1c, blood pressure, non-HDLC, and lifestyle risks such as smoking and no physical activity are associated with FD in those with and without DM.

Enrolled were 9652 Japanese aged 39-98 y. FD was defined based on the Japanese long-term care insurance system, and targets were based on ADA and Japanese guidelines.

Of 8,861 non-DM persons, 6.3, 25.2 and 49.1% were on target for 0-2, 3 and 4 factors, respectively. Of 791 persons with DM, 12.4, 68.0 and 19.3% were on target for 0-2, 3-4 and 5 factors, respectively.

Multivariate Cox analysis showed increased FD with decreased targets reached regardless of DM (Table, upper). Compared with people with non-DM who achieved 4 targets, non-DM persons who achieved 0 to 2 targets and DM persons who achieved 3 to 4 targets had nearly twice the incidence of FD (Table, lower). Moreover, people with DM who achieved only 0 to 2 targets had an approximately 4 times higher incidence of FD (Table, lower). Control of modifiable risk factors was effective regardless of DM. Achievement of all 5 targets among people with DM may reduce FD to the same level as in non-DM persons who achieved all 4 targets.

 Disclosure

H. Shiozaki: None. K. Fujihara: None. K. Tsuruoka: None. I. Ikeda: None. M. Kitazawa: None. Y. Matsubayashi: None. M. Yamamoto: None. T. Yamada: None. S. Kodama: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kowa Company, Ltd., Kyowa Kirin Co., Ltd., Eisai Inc., Sumitomo Dainippon Pharma Co., Ltd.

Funding

the Japan Society for the Promotion of Science (21K11569); Daiwa Securities Health Foundation

DOI： 10.2337/db24-1259-p

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Reduced chondroitin sulfate content prevents diabetic neuropathy through transforming growth factor-β signaling suppression. International journal

Hajime Ishiguro, Takashi Ushiki, Atsuko Honda, Yasuhiro Yoshimatsu, Riuko Ohashi, Shujiro Okuda, Asami Kawasaki, Kaori Cho, Suguru Tamura, Tatsuya Suwabe, Takayuki Katagiri, Yiwei Ling, Atsuhiko Iijima, Tadahisa Mikami, Hiroshi Kitagawa, Akiyoshi Uemura, Kazunori Sango, Masayoshi Masuko, Michihiro Igarashi, Hirohito Sone

iScience 27 ( 4 ) 109528 - 109528 2024.4

Language：English Publishing type：Research paper (scientific journal)

Diabetic neuropathy (DN) is a major complication of diabetes mellitus. Chondroitin sulfate (CS) is one of the most important extracellular matrix components and is known to interact with various diffusible factors; however, its role in DN pathology has not been examined. Therefore, we generated CSGalNAc-T1 knockout (T1KO) mice, in which CS levels were reduced. We demonstrated that diabetic T1KO mice were much more resistant to DN than diabetic wild-type (WT) mice. We also found that interactions between pericytes and vascular endothelial cells were more stable in T1KO mice. Among the RNA-seq results, we focused on the transforming growth factor β signaling pathway and found that the phosphorylation of Smad2/3 was less upregulated in T1KO mice than in WT mice under hyperglycemic conditions. Taken together, a reduction in CS level attenuates DN progression, indicating that CS is an important factor in DN pathogenesis.

DOI： 10.1016/j.isci.2024.109528

PubMed

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Usefulness of New Criteria for Metabolic Syndrome Optimized for Prediction of Cardiovascular Diseases in Japanese.

Yurie Yamazaki, Kazuya Fujihara, Takaaki Sato, Mayuko Harada Yamada, Yuta Yaguchi, Yasuhiro Matsubayashi, Takaho Yamada, Satoru Kodama, Kiminori Kato, Hitoshi Shimano, Hirohito Sone

Journal of atherosclerosis and thrombosis 31 ( 4 ) 382 - 395 2024.4

Language：English Publishing type：Research paper (scientific journal)

AIMS: We attempted to clarify whether the multiple criteria for metabolic syndrome (MetS) can sufficiently predict cardiovascular disease, whether waist circumference (WC) should be required, and whether sex-specific thresholds for each component are necessary. Only a few large-scale studies among East Asians have addressed the ability of MetS to predict cardiovascular disease. METHODS: We analyzed the data of 330,051 men and 235,028 women aged 18-74 years with no history of coronary artery disease (CAD) or cerebrovascular disease (CVD) from a nationwide Japanese claims database accumulated during 2008-2016. The association of each MetS component with CAD or CVD (CAD/CVD), MetS associated with CAD/CVD according to various criteria, and utility of modified criteria with more specific optimal values for each component were examined using multivariate Cox regression and receiver operating characteristic (ROC) analysis. RESULTS: During the study, 3,934 men (1.19%) and 893 women (0.38%) developed CAD/CVD. For each current MetS criteria, there was a 1.3- to 2.9-fold increased risk of CAD/CVD. Optimal thresholds for predicting CAD/CVD were WCs of 83 and 77 cm, triglycerides levels of 130 and 90 mg/dl, high-density lipoprotein cholesterol levels of 50 and 65 mg/dl, blood pressures of 130/80 and 120/80 mmHg, and fasting plasma glucose levels of 100 and 90 mg/dl for men and women, respectively. The existing MetS criteria and modified criteria were not significantly different in predicting CAD/CVD, but using the modified criteria markedly increased the prevalence of MetS and percentage of people with MetS developing CAD/CVD. CONCLUSIONS: Although various criteria for MetS similarly predicted CAD/CVD, the new criteria greatly reduced the number of high-risk individuals, especially women, overlooked by the current criteria.

DOI： 10.5551/jat.64380

PubMed

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糖尿病(DM)の有無別にみた生活習慣関連因子(Cardiovascular Health Metrics)が腎透析導入(HD)に及ぼす影響の検討

大澤妙子, 藤原和哉, 山田万祐子, 矢口雄大, 佐藤隆明, 北澤勝, 松林泰弘, 山田貴穂, 曽根博仁

糖尿病 67 ( Suppl.1 ) S - 168 2024.4

糖尿病患者における重症合併症の複合アウトカム(CSDC)の発症リスク因子の検討

田中菜々子, 矢口雄大, 佐藤隆明, 大澤妙子, 鈴木浩史, 山田貴穂, 藤原和哉, 曽根博仁

糖尿病 67 ( Suppl.1 ) S - 186 2024.4

代謝異常を伴う脂肪肝(MASLD)サブタイプのトランジションとCVD新規発症との関連について

松林泰弘, 藤原和哉, 山田万祐子, 佐藤隆明, 矢口雄大, 山本正彦, 石黒創, 大澤妙子, 北澤勝, 山田貴穂, 曽根博仁

糖尿病 67 ( Suppl.1 ) S - 215 2024.4

新規開発した総合体力指標フィジカルスコアによる各種代謝疾患の発症予測能の検討

佐藤隆明, 藤原和哉, 矢口雄大, 山本正彦, 北澤勝, 鈴木浩史, 松林泰弘, 石黒創, 大澤妙子, 山田貴穂, 加藤公則, 曽根博仁

糖尿病 67 ( Suppl.1 ) S - 216 2024.4

糖尿病予備群(preDM)におけるHbA1c,空腹時血糖(FPG)およびそれらの組み合わせによる脳心血管疾患(CVD)発症リスクの関連

村井幸四郎, 藤原和哉, 山田万祐子, 矢口雄大, 北澤勝, 山本正彦, 佐藤隆明, 松林泰弘, 山田貴穂, 曽根博仁

糖尿病 67 ( Suppl.1 ) S - 247 2024.4

メタボリックシンドローム(MetS)の経年的変化と心血管疾患発症の関連

滝澤大輝, 藤原和哉, 三ツ間友里恵, 山田万祐子, 村井幸四郎, 佐藤隆明, 矢口雄大, 山本正彦, 大澤妙子, 北澤勝, 松林泰弘, 岩永みどり, 山田貴穂, 曽根博仁

糖尿病 67 ( Suppl.1 ) S - 249 2024.4

写真撮影を含むスマートフォンアプリを用いた自由行動下での利用者及び医療者の負担を最小限とする食事記録方法の検討

北澤勝, 堀川千嘉, 長谷川美代, 武田安永, 松林泰弘, 山田貴穂, 児玉暁, 曽根博仁

日本栄養・食糧学会大会講演要旨集 78回 242 - 242 2024.4

PHRスマートフォンアプリとisCGMを連動させた2型糖尿病発症予防プログラムの有効性検証のためのランダム化比較試験

北澤勝, 武田安永, 治田麻理子, 堀川千嘉, 佐藤隆明, 大澤妙子, 石澤正博, 鈴木浩史, 松林泰弘, 藤原和哉, 山田貴穂, 曽根博仁

糖尿病 67 ( Suppl.1 ) S - 216 2024.4

日本人2型糖尿病患者における,飽和脂肪酸エネルギー比率と心血管疾患発症との関係 JDCP studyの解析から

堀川千嘉, 高原充佳, 片上直人, 武田安永, 竹内瑞希, 藤原和哉, 鈴木浩明, 津田謹輔, 吉岡成人, 島野仁, 佐藤譲, 林野泰明, 田嶼尚子, 西村理明, 山崎義光, 曽根博仁

糖尿病 67 ( Suppl.1 ) S - 169 2024.4

Decade-long WT1-specific CTLs induced by WT1 peptide vaccination.

Tatsuya Suwabe, Yasuhiko Shibasaki, Suguru Tamura, Takayuki Katagiri, Kyoko Fuse, Tori Ida-Kurasaki, Takashi Ushiki, Hirohito Sone, Miwako Narita, Masayoshi Masuko

International journal of hematology 119 ( 4 ) 399 - 406 2024.4

Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: The peptide-based cancer vaccine targeting Wilms' tumor 1 (WT1) is a promising immunotherapeutic strategy for hematological malignancies. It remains unclear how long and to what extent the WT1-specific CD8 + cytotoxic T cell (CTL) persist after WT1 peptide vaccination. METHODS: The WT1 peptide vaccine was administered with written consent to a patient with CML in the chronic phase who did not respond well to imatinib, and the patient was followed for 12 years after vaccination. Immune monitoring was performed by specific amplification of WT1-specific CTLs using a mixed lymphocyte peptide culture. T-cell receptors (TCRs) of amplified WT1-specific CTLs were analyzed using next-generation sequencing. This study was approved by the Institutional Review Board of our institution. RESULT: WT1-specific CTLs, which were initially detected during WT1 peptide vaccination, persisted at a frequency of less than 5 cells per 1,000,000 CD8 + T cells for more than 10 years. TCR repertoire analysis confirmed the diversity of WT1-specific CTLs 11 years after vaccination. CTLs exhibited WT1 peptide-specific cytotoxicity in vitro. CONCLUSION: The WT1 peptide vaccine induced an immune response that persists for more than 10 years, even after cessation of vaccination in the CML patient.

DOI： 10.1007/s12185-024-03723-1

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詳細な家族歴が2型糖尿病,高血圧,脂質異常症の有病と発症に与える影響の横断縦断的検討

池田和泉, 五十嵐理沙, 藤原和哉, 武田安永, 松林泰弘, 児玉暁, 山田貴穂, 森保道, 門脇孝, 本田律子, 荒瀬康司, 曽根博仁

糖尿病 67 ( Suppl.1 ) S - 194 2024.4

Higher dietary protein/energy ratio is associated with a lower risk for obesity in older women with type 2 diabetes: Cross-sectional analysis of Japanese patients with type 2 diabetes mellitus

Efrem d'Ávila Ferreira, Mariko Hatta, Khin Laymon, Izumi Ikeda, Mizuki Takeuchi, Yasunaga Takeda, Sakiko Yoshizawa Morikawa, Chika Horikawa, Noriko Kato, Hiroshi Maegawa, Kazuya Fujihara, Hirohito Sone

Human Nutrition & Metabolism 200257 - 200257 2024.3

Cross-Sectional and Longitudinal Associations between Forearm Bone Mineral Density and Anthropometry in Adult Japanese Men and Women

Masahiro Ishizawa, Kazuya Fujihara, Junko Yachida, Izumi Ikeda, Takaaki Sato, Takaho Yamada, Ayako Kobayashi, Shiro Tanaka, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano, Minoru Tashiro, Satoru Kodama, Kiminori Kato, Hirohito Sone

Journal of Bone Metabolism 31 ( 1 ) 21 - 30 2024.2

機能性甲状腺結節による甲状腺中毒症を誘因として糖尿病性ケトアシドーシスを来し甲状腺クリーゼを発症した一例

間島貴之, 鈴木浩史, 木村智佑, 佐藤隆明, 山本雅彦, 石黒創, 岩永みどり, 松林泰弘, 山田貴穂, 藤原和哉, 曽根博仁

日本内分泌学会雑誌 99 ( 4 ) 884 - 884 2024.1

機能性甲状腺結節による甲状腺中毒症を誘因として糖尿病性ケトアシドーシスを来し甲状腺クリーゼを発症した一例

間島貴之, 鈴木浩史, 木村智佑, 佐藤隆明, 山本雅彦, 石黒創, 岩永みどり, 松林泰弘, 山田貴穂, 藤原和哉, 曽根博仁

日本内分泌学会雑誌 99 ( 4 ) 884 - 884 2024.1

副交感神経障害を伴わず糖尿病性動眼神経麻痺との鑑別に難渋した下垂体卒中による動眼神経麻痺の一例

深井悠未, 村井幸四郎, 今西明, 矢口雄大, 北澤勝, 鈴木浩史, 松林泰弘, 藤原和哉, 岩永みどり, 山田貴穂, 曽根博仁, 岡田正康

日本内分泌学会雑誌 99 ( 4 ) 895 - 895 2024.1

2型糖尿病患者におけるカリウム摂取量およびナトリウム摂取量と心血管疾患発症リスクの関係 JDCP study

Journal of Epidemiology 34 ( Suppl. ) 163 - 163 2024.1

副交感神経障害を伴わず糖尿病性動眼神経麻痺との鑑別に難渋した下垂体卒中による動眼神経麻痺の一例

深井悠未, 村井幸四郎, 今西明, 矢口雄大, 北澤勝, 鈴木浩史, 松林泰弘, 藤原和哉, 岩永みどり, 山田貴穂, 曽根博仁, 岡田正康

日本内分泌学会雑誌 99 ( 4 ) 895 - 895 2024.1

ACTH産生PitNETの集学的治療戦略と成績

岡田正康, 平石哲也, 米岡有一郎, 石黒創, 北澤勝, 曽根博仁, 大石誠

日本内分泌学会雑誌 99 ( 4 ) 896 - 896 2024.1

Association between screen time, including that for smartphones, and overweight/obesity among children in Japan: NICE EVIDENCE Study 4

Izumi Ikeda, Kazuya Fujihara, Sakiko Morikawa Yoshizawa, Yasunaga Takeda, Hajime Ishiguro, Mayuko Yamada Harada, Chika Horikawa, Yasuhiro Matsubayashi, Takaho Yamada, Yohei Ogawa, Hirohito Sone

Endocrine Journal 2024

トリュフによる血糖上昇抑制効果

鈴木浩史, 渡辺賢一, カク・アンジュ, ウー・シージャ, 石黒創, 井口晃徳, 小西徹也, 曽根博仁

機能性食品と薬理栄養 17 ( 3 ) 201 - 201 2023.12

isCGMとPHRスマートフォンアプリを用いた糖尿病発症予防プログラムの有効性検証のためのランダム化比較試験

北澤勝, 武田安永, 治田麻理子, 堀川千嘉, 佐藤隆明, 大澤妙子, 石澤正博, 鈴木浩史, 松林泰弘, 藤原和哉, 山田貴穂, 曽根博仁

日本先進糖尿病治療研究会雑誌 17 ( 3 ) 152 - 152 2023.12

"Lifestyle Intervention with Smartphone app and isCGM for People at High Risk of Type 2 Diabetes: Randomized Trial". International journal

Masaru Kitazawa, Yasunaga Takeda, Mariko Hatta, Chika Horikawa, Takaaki Sato, Taeko Osawa, Masahiro Ishizawa, Hiroshi Suzuki, Yasuhiro Matsubayashi, Kazuya Fujihara, Takaho Yamada, Hirohito Sone

The Journal of clinical endocrinology and metabolism 2023.11

Language：English Publishing type：Research paper (scientific journal)

AIMS: Although conventional interventions for people at high risk of developing type 2 diabetes are usually conducted face-to-face, such interventions are burdensome for healthcare providers. We developed a lifestyle intervention program combining lifestyle coaching via a smartphone application augmented by intermittently scanned continuous glucose monitoring (isCGM) without burdening healthcare providers. Its effectiveness for glycemic control and body weight reduction in people at risk of type 2 diabetes was investigated. MATERIALS AND METHODS: For this 12-week randomized unblinded trial with offline recruitment, participants with HbA1c 5.6-6.4% or fasting blood glucose 110-125 mg/dl and body mass index (BMI) > 23 kg/m2 but <40 kg/m2 were randomly assigned to the Intervention group (App) and Control group (C). Primary endpoint was the difference in time in range (TIR) of blood glucose 70-140 mg/dL (3.9-7.8 mmol/L) before and after the study period between the two groups. RESULTS: Among 168 patients (mean age 48.1 y, mean BMI 26.6 kg/m2, and male 80.4%), 82 and 86 were assigned to the App group and C group, respectively. After 12 weeks, TIR of blood glucose 70-140 mg/dL significantly improved in the App group compared to the C group (-2.6 min/day vs. + 31.5 min/day, p = 0.03). Changes in time above range did not differ, whereas time below range (blood glucose <70 mg/dL; + 23.5 min/day vs. -8.9 min/day, p = 0.02) improved in the App group. BMI (-0.26 vs. -0.59, p = 0.017) was reduced in the App group compared to the C group. CONCLUSION: Intervention with a smartphone app and isCGM increased glycemic control accompanied by decreased carbohydrate intake and weight loss. Further trials are needed to confirm whether these interventions can reduce incident type 2 diabetes.

DOI： 10.1210/clinem/dgad639

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Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids. International journal

Song-Iee Han, Masanori Nakakuki, Yoshimi Nakagawa, Yunong Wang, Masaya Araki, Yuta Yamamoto, Hiroaki Tokiwa, Hiroyuki Takeda, Yuhei Mizunoe, Kaori Motomura, Hiroshi Ohno, Kenta Kainoh, Yuki Murayama, Yuichi Aita, Yoshinori Takeuchi, Yoshinori Osaki, Takafumi Miyamoto, Motohiro Sekiya, Takashi Matsuzaka, Naoya Yahagi, Hirohito Sone, Hiroaki Daitoku, Ryuichiro Sato, Hiroyuki Kawano, Hitoshi Shimano

PNAS nexus 2 ( 11 ) pgad351 2023.11

Language：English Publishing type：Research paper (scientific journal)

The endoplasmic reticulum (ER)-embedded transcription factors, sterol regulatory element-binding proteins (SREBPs), master regulators of lipid biosynthesis, are transported to the Golgi for proteolytic activation to tune cellular cholesterol levels and regulate lipogenesis. However, mechanisms by which the cell responds to the levels of saturated or unsaturated fatty acids remain underexplored. Here, we show that RHBDL4/RHBDD1, a rhomboid family protease, directly cleaves SREBP-1c at the ER. The p97/VCP, AAA-ATPase complex then acts as an auxiliary segregase to extract the remaining ER-embedded fragment of SREBP-1c. Importantly, the enzymatic activity of RHBDL4 is enhanced by saturated fatty acids (SFAs) but inhibited by polyunsaturated fatty acids (PUFAs). Genetic deletion of RHBDL4 in mice fed on a Western diet enriched in SFAs and cholesterol prevented SREBP-1c from inducing genes for lipogenesis, particularly for synthesis and incorporation of PUFAs, and secretion of lipoproteins. The RHBDL4-SREBP-1c pathway reveals a regulatory system for monitoring fatty acid composition and maintaining cellular lipid homeostasis.

DOI： 10.1093/pnasnexus/pgad351

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Single-cell transcriptome profiling of pancreatic islets from early diabetic mice identifies Anxa10 for Ca2+ allostasis toward β-cell failure. International journal

Kaori Motomura, Takashi Matsuzaka, Shigeyuki Shichino, Tatsuro Ogawa, Hao Pan, Takuya Nakajima, Yasuhito Asano, Toshitsugu Okayama, Tomoyo Takeuchi, Hiroshi Ohno, Song-Iee Han, Takafumi Miyamoto, Yoshinori Takeuchi, Motohiro Sekiya, Hirohito Sone, Naoya Yahagi, Yoshimi Nakagawa, Tatsuya Oda, Satoshi Ueha, Kazuho Ikeo, Atsushi Ogura, Kouji Matsushima, Hitoshi Shimano

Diabetes 2023.10

Language：English Publishing type：Research paper (scientific journal)

Type 2 diabetes (T2D) is a progressive disorder denoted by hyperglycemia and impaired insulin secretion. Although a decrease in β-cell function and mass is a well-known trigger for diabetes, the comprehensive mechanism is still unidentified. Here we carried out single-cell RNA sequencing (scRNA-seq) of pancreatic islets from prediabetic and diabetic db/db mice, an animal model of T2D. We discovered a diabetes-specific transcriptome landscape of endocrine and nonendocrine cell types with subpopulations of β and α cells. We recognized a new prediabetic gene, Anxa10, that was induced by, and regulated Ca2+ influx from metabolic stresses. Anxa10-overexpressed β cells displayed suppression of glucose-stimulated intracellular Ca2+ elevation and potassiuminduced insulin secretion. Pseudotime analysis of β cells predicted this Ca2+-surge responder-cluster proceeded to mitochondria dysfunction and also endoplasmic reticulum stress. Other trajectories comprised dedifferentiation and transdifferentiation, emphasizing acinar-like cells in diabetic islets. Altogether, our data provides a new insight into Ca2+ allostasis and β cell failure processes.

DOI： 10.2337/db23-0212

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妊娠糖尿病既往女性のフォローアップに関する診療ガイドライン

平松祐司, 杉山隆, 安日一郎, 曽根博仁, 菊池透, 瀧本秀美, 安田和基, 小川佳宏, 荒田尚子, 和栗雅子, 橋本貢士, 宮越敬, 山下洋, 鳴本敬一郎, 青山友子, 山本周美, 川崎麻紀, Obaidur Rahman, 川嵜有紀, 大田えりか, 内潟安子, 川崎英二, 守屋達美, 上塘正人, 田中幹二, 増山寿, 森川守, 楠田聡, 杉原茂孝, 清水一紀, 武田純, 原島伸一, 柳澤慶香, 田中佳代, 人見麻美子, 板倉敦夫, 寺内康夫, 平成30年度日本医療研究開発機構日本医療研究開発機構女性の健康の包括的支援実用化研究事業「妊娠糖尿病女性における出産後の糖尿病・メタボリックシンドローム発症のリスク因子同定と予防介入に関する研究」研究班, 一般社団法人日本糖尿病・妊娠学会

糖尿病と妊娠 23 ( 別冊 ) 1 - 95 2023.10

握力、閉眼片足立ち、立位体前屈による総合体力指標は代謝性疾患のスクリーニングに有用である

佐藤隆明, 藤原和哉, 山田万祐子, 張かおり, 矢口雄大, 山本正彦, 北澤勝, 石黒創, 大澤妙子, 山田貴穂, 加藤公則, 曽根博仁

日本臨床運動療法学会学術集会プログラム・抄録集 42回 61 - 61 2023.10

妊娠糖尿病既往女性のフォローアップに関する診療ガイドライン

糖尿病と妊娠 23 ( 別冊 ) 1 - 95 2023.10

血糖コントロールと妊娠合併症リスクとの量反応関係メタ回帰分析

児玉暁, 山田貴穂, 柳生田紀子, 谷内洋子, 堀川千嘉, 大澤妙子, 北澤勝, 藤原和哉, 西島浩二, 曽根博仁

糖尿病と妊娠 23 ( 3 ) S - 109 2023.10

規制改革特区を活用したGDM妊婦の産後12週以降の管理の全国一律保健適応化の実現

牧尉太, 衛藤英理子, 宮越敬, 曽根博仁, 安日一郎, 杉山隆, 増山寿

糖尿病と妊娠 23 ( 3 ) S - 125 2023.10

単一施設における節外性NK/T細胞リンパ腫、鼻腔(ENKL)における26例の後方視的解析 EBV-DNA定量の有用性

山田隆, 古山悠里, 水戸部正樹, 米沢穂高, 鈴木隆晴, 諏訪部達也, 片桐隆幸, 河本啓介, 布施香子, 柴崎康彦, 増子正義, 大島孝一, 曽根博仁, 瀧澤淳

日本血液学会学術集会 85回 294 - 294 2023.10

当科におけるIVLBCL22例の後方視的解析

鈴木隆晴, 水戸部正樹, 武田ルイ, 諏訪部達也, 片桐隆幸, 河本啓介, 宮腰淑子, 北嶋俊樹, 小堺貴司, 柴崎康彦, 黒田裕行, 棗田学, 大島孝一, 曽根博仁, 瀧澤淳

日本血液学会学術集会 85回 557 - 557 2023.10

同種移植後day30の末梢血CD8TN、CD4TEM割合は急性GVHD発症のバイオマーカーとなる

片桐隆幸, 古山悠里, 米沢穂高, 諏訪部達也, 布施香子, 柴崎康彦, 瀧澤淳, 曽根博仁, 増子正義

日本血液学会学術集会 85回 880 - 880 2023.10

WT1ペプチドワクチン投与後10年間以上にわたり持続するWT1特異的な細胞傷害性T細胞

諏訪部達也, 柴崎康彦, 田村秀, 片桐隆幸, 井田桃里, 布施香子, 牛木隆志, 曽根博仁, 成田美和子, 増子正義

日本血液学会学術集会 85回 117 - 117 2023.10

心血管疾患脂肪肝の表現型,及び2型糖尿病が心不全の新規発症に与えるインパクト

松林泰弘, 藤原和哉, 山田万祐子, 佐藤隆明, 矢口雄大, 山本正彦, 石黒創, 大澤妙子, 北澤勝, 岩永みどり, 山田貴穂, 曽根博仁

糖尿病合併症 37 ( Suppl.1 ) 164 - 164 2023.9

Associations among metabolic health, weight status, and various physical fitness components in Japanese adolescents: a cross-sectional study (NICE EVIDENCE study- Agano 3). International journal

Sakiko Yoshizawa Morikawa, Yasunaga Takeda, Kazuya Fujihara, Izumi Ikeda, Ayako Kobayashi, Mariko Hatta, Yurie Mitsuma, Chika Horikawa, Hajime Ishiguro, Takaho Yamada, Yohei Ogawa, Hirohito Sone

Journal of sports sciences 41 ( 13 ) 1279 - 1289 2023.9

Language：English Publishing type：Research paper (scientific journal)

Aim was to examine associations among metabolic health, weight status, and various physical fitness (PF) components in 1744 Japanese adolescents aged 13-14. Anthropometric measurements and PF tests (20 m shuttle run test [20mSRT], handgrip strength/body mass [HG], standing long jump [SLJ], and sit ups [SU]) were administered. The bottom sex-specific quintile of PF indicated "low fit". Participants were classified as non-overweight (non-OW) or overweight/obese (OW) according to the International Obesity Task Force. Clustered metabolic risk was defined as the sum of Z scores for mean arterial pressure, non-high-density lipoprotein cholesterol, and HbA1c, divided by three, and ≥ 1 SD. Combination of weight status and scores for HG or SU were additively associated with clustered metabolic risk. Compared with the non-OW-moderate-high fit group, the OW-low HG group was 3.05 (95%CI: 1.88-4.97) times more likely to have clustered metabolic risk although risk was not significantly elevated in the OW-moderate-high HG group (1.52 [95%CI: 0.88-2.62]). A similar association was observed between OW and low SU scores but not between OW and low 20mSRT or SLJ scores. Adolescents with OW and moderate-high HG or SU scores had a lower prevalence of an unfavourable metabolic state than those with OW and low HG or SU results.

DOI： 10.1080/02640414.2023.2268358

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Genetic manipulation resulting in decreased donor chondroitin sulfate synthesis mitigates hepatic GVHD via suppression of T cell activity. International journal

Suguru Tamura, Hajime Ishiguro, Tatsuya Suwabe, Takayuki Katagiri, Kaori Cho, Kyoko Fuse, Yasuhiko Shibasaki, Tadahisa Mikami, Takero Shindo, Hiroshi Kitagawa, Michihiro Igarashi, Hirohito Sone, Masayoshi Masuko, Takashi Ushiki

Scientific reports 13 ( 1 ) 13098 - 13098 2023.8

Language：English Publishing type：Research paper (scientific journal)

Donor T cell activation, proliferation, differentiation, and migration are the major steps involved in graft-versus-host disease (GVHD) development following bone marrow transplantation. Chondroitin sulfate (CS) proteoglycan is a major component of the extracellular matrix and causes immune modulation by interacting with cell growth factors and inducing cell adhesion. However, its precise effects on immune function are unclear than those of other proteoglycan families. Thus, we investigated the significance of CS within donor cells in acute GVHD development utilizing CSGalNAc T1-knockout (T1KO) mice. To determine the effects of T1KO, the mice underwent allogenic bone marrow transplantation from major histocompatibility complex-mismatched donors. While transplantation resulted in hepatic GVHD with inflammatory cell infiltration of both CD4+ and CD8+ effector memory T cells, transplantation in T1KO-donors showed milder cell infiltration and improved survival with fewer splenic effector T cells. In vitro T-cell analyses showed that the ratio of effector memory T cells was significantly lower via phorbol myristate acetate/ionomycin stimulation. Moreover, quantitative PCR analyses showed significantly less production of inflammatory cytokines, such as IFN-γ and CCL-2, in splenocytes of T1KO mice. These results suggest that reduction of CS in donor blood cells may suppress the severity of acute GVHD after hematopoietic stem cell transplantation.

DOI： 10.1038/s41598-023-40367-3

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Relationship between the magnitude of body mass index reductions and remission in patients with type 2 diabetes in real world settings: Analysis of nationwide patient registry in Japan (JDDM74) Reviewed International journal

Hirohito Sone

Diabetes, Obesity and Metabolism 2023.7

Retrospective cohort study to examine the association between serum amylase and the incidence of type 2 diabetes mellitus, Toranomon Hospital Health Management Center Study 23 (TOPICS 23). International journal

Izumi Ikeda, Kazuya Fujihara, Taeko Osawa, Yasunaga Takeda, Mariko Hatta, Yasuhiro Matsubayashi, Satoru Kodama, Yasumichi Mori, Takashi Kadowaki, Ritsuko Honda, Yasuji Arase, Hirohito Sone

BMJ open diabetes research & care 11 ( 4 ) 2023.7

Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: Low serum amylase values are cross-sectionally associated with the prevalence of type 2 diabetes mellitus (T2DM) but have not been shown to be longitudinally associated with its incidence. This retrospective cohort (ie, historical cohort) study aimed to examine the association of previously lowered levels of serum amylase with incident T2DM. RESEARCH DESIGN AND METHODS: Examined were 8316 individuals who had annual health examinations for 6 years (ie, 7 times) at the Toranomon Hospital Health Management Center. The trajectory of serum amylase as the study exposure was classified into two elements: (1) serum amylase level at entry and (2) change in serum amylase, which was expressed as the annual change rate. The annual change rate was calculated by dividing the change in the amylase values according to follow-up periods. Regression analyses were performed to examine the association between low and decreased levels of serum amylase and the incidence of T2DM. RESULTS: Analyzed were 6917 individuals who had not developed T2DM within 1 year after cohort entry. T2DM thereafter occurred in 1021 patients. Cox regression indicated that the adjusted HR (95% CI) for incident T2DM for amylase ≤57 IU/L (quintile (Q) 1) was 0.97 (0.84 to 1.13) compared with amylase ≥58 IU/L (Q2-Q5). Logistic regression indicated that the adjusted OR (95% CI) for an annual change rate of amylase ≤-2.0% (Q1) vs ≥-1.9% (Q2-Q5) was 3.53 (3.00 to 4.16). The adjusted ORs were consistently significant throughout sensitivity analyses according to baseline amylase and the combination of age, body mass index, and hemoglobin A1c. CONCLUSIONS: Results showed that not low but previously decreased serum amylase was a risk factor for T2DM, suggesting the significance of periodic examinations of serum amylase values to detect individuals at high risk of T2DM.

DOI： 10.1136/bmjdrc-2023-003482

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Enfortumab Vedotin-induced Hyperglycemia and Ileal Conduit Reconstruction-induced Metabolic Acidosis. International journal

Takaaki Sato, Hiroshi Suzuki, Yuya Asashima, Hirohito Sone

JCEM case reports 1 ( 4 ) luad092 2023.7

Language：English

We report a 76-year-old man who was treated for hyperglycemia and metabolic acidosis after chemotherapy with enfortumab vedotin and pembrolizumab administered after his surgery for bladder cancer. He had an approximately 20-year history of diabetes. His body mass index was 18.6, and he received metformin 1000 mg/day, sitagliptin 50 mg/day, mitiglinide 30 mg/day, and voglibose 0.6 mg/day with hemoglobin A1c was approximately 7%. He underwent total cystectomy and ileal conduit reconstruction. After relapse, he received chemotherapy but later developed hyperglycemia and metabolic acidosis. His hyperglycemia was caused by enfortumab vedotin, and metabolic acidosis was attributable to the ileocecal canal. These symptoms should be remembered as important complications of this standard treatment, which prompted this case report.

DOI： 10.1210/jcemcr/luad092

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エンフォルツマブによる高血糖と回腸導管による代謝性アシドーシスをきたした1例

浅島雄弥, 佐藤隆明, 佐々木知佳, 鈴木浩史, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

糖尿病 66 ( 7 ) 568 - 568 2023.7

劇症1型糖尿病発症時にST上昇を呈し偽性心筋梗塞と考えられた1例

佐藤駿匡, 北澤勝, 滝澤祥子, 今西明, 山田万祐子, 松林泰弘, 藤原和哉, 山田貴穂, 保屋野真, 曽根博仁

糖尿病 66 ( 7 ) 570 - 570 2023.7

329-OR: Accuracy of Dietary Records (DR) Using a Smartphone App Is Greatly Improved by User’s Adjustments Compared with Artificial Intelligence (AI) Alone

MASARU KITAZAWA, CHIKA HORIKAWA, IZUMI IKEDA, YASUNAGA TAKEDA, EFREM D. FERREIRA, MIZUKI TAKEUCHI, SAKIKO Y. MORIKAWA, KAZUYA FUJIHARA, SATORU KODAMA, HIROHITO SONE

Diabetes 72 ( Supplement_1 ) 2023.6

Publishing type：Research paper (scientific journal) Publisher：American Diabetes Association

Although DR are important in managing diabetes, the traditional method, such as weighing foods and calculating nutrients, is burdensome to both patients and medical care providers. Although photo DR with smartphones using AI to identify the dish and calculate nutrients can be expected to reduce this burden, accuracy not been clarified. Furthermore, it is not clear to what extent accuracy improves when users and dietitians adjust the name of the dish and the portion consumed compared with AI only. In this study, photo DR taken with the smartphone app were analyzed by AI only, then adjusted by the users followed by further adjustments by a dietitian. We compared the nutrients calculated by AI, users, and dietitians to those by the traditional weighing method. Analyzed were 180 participants (mean age 58.7 y, BMI 26.7 kg/m2, 94/86 women/men, 22 with diabetes, energy intake [EI] 1640 kcal/day) The EIs (kcal/day) were calculated as 1502, 1619, and 1674 for AI, users, and dietitians, respectively, those were lower than that with the weighing method Spearman's rank correlation coefficients compared to the weighing method were 0.48, 0.88, and 0.88 for AI, users and dietitians, respectively, showing a weak correlation for AI and a strong correlation for users and dietitians. The user's adjustments greatly improved accuracy without increasing the burden on the dietitians.

 Disclosure

M.Kitazawa: None. H.Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kyowa Kirin Co., Ltd., Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., Eisai Co., Ltd., Takeda Pharmaceutical Co., Ltd. C.Horikawa: None. I.Ikeda: None. Y.Takeda: None. E.D.Ferreira: None. M.Takeuchi: None. S.Y.Morikawa: None. K.Fujihara: None. S.Kodama: None.

Funding

Grants-in-Aid for Scientific Research (21K17637)

DOI： 10.2337/db23-329-or

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1357-P: Conflicting Significance of High BMI as a Predictor of Individual Diabetic Complications

YUTA YAGUCHI, KAZUYA FUJIHARA, LAY MON KHIN, SIJIA WU, EFREM D. FERREIRA, TAKAAKI SATO, CHIKA HORIKAWA, YASUHIRO MATSUBAYASHI, KIMINORI KATO, HIROHITO SONE

Diabetes 72 ( Supplement_1 ) 2023.6

Publishing type：Research paper (scientific journal) Publisher：American Diabetes Association

Although weight management plays a central role in diabetes treatment, the association between body weight and diabetic complications is not fully elucidated. Therefore, we investigated the relationship between BMI and risk of diabetic complications in patients with diabetes mellius (DM) using nationwide claims data. Analyzed were 91097 patients with DM without prior treatment-requiring diabetic eye disease (TRDED), initiation of dialysis (dialysis), coronary artery disease (CAD), cerebrovascular disease (CVD), heart failure (HF) or amputation (mean age 52 y, HbA1c 7.2%, median follow-up 4.5 y). Participants were divided into 6 groups according to BMI (BMI&lt;20.0, 20.0-22.4, 22.5-24.9, 25.0-27.4, 27.5-29.0, ≥30.0). Risk of diabetic complications was examined by Cox regression analysis. There was an inverse correlation between the risk of dialysis and BMI; hazard ratio (HR) for dialysis in patients with BMI ≥30.0 was 0.46 (0.29-0.74). There was a U-shaped relationship between the risk of HF and BMI; HRs for HF in patients with BMI &lt;20.0 and ≥30.0 were 1.97 (1.15-3.37) and 1.76 (1.27-2.45), respectively (Figure). High BMI was significantly associated with a higher risk of HF, but lower risks of TRDED and dialysis. The relationship between BMI and diabetic complications was inconsistent among complications, suggesting that the target weight should be individualized according to diabetic complications.

 Disclosure

Y.Yaguchi: None. H.Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kyowa Kirin Co., Ltd., Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., Eisai Co., Ltd., Takeda Pharmaceutical Co., Ltd. K.Fujihara: None. L.Khin: None. S.Wu: None. E.D.Ferreira: None. T.Sato: None. C.Horikawa: None. Y.Matsubayashi: None. K.Kato: None.

DOI： 10.2337/db23-1357-p

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1381-P: Effect of Dietary Potassium Intake and Its Interaction with Sodium Intake on Risk of Developing Cardiovascular Disease (CVD) in Persons with Type 2 Diabetes (T2D)—Japan Diabetes Complication and Its Prevention Prospective Study (JDCP Study)

CHIKA HORIKAWA, MITSUYOSHI TAKAHARA, NAOTO KATAKAMI, YASUNAGA TAKEDA, MIZUKI TAKEUCHI, KAZUYA FUJIHARA, HIROAKI SUZUKI, KINSUKE TSUDA, NARIHITO YOSHIOKA, HITOSHI SHIMANO, JO SATOH, YASUAKI HAYASHINO, NAOKO TAJIMA, RIMEI NISHIMURA, YOSHIMITSU YAMASAKI, HIROHITO SONE

Diabetes 72 ( Supplement_1 ) 2023.6

Publishing type：Research paper (scientific journal) Publisher：American Diabetes Association

Many guidelines recommend increased potassium intake. However, the relationship between dietary potassium intake and incidence of CVD in persons with T2D has not been explored, nor is it known if this relationship varies with sodium intake in such persons. Therefore, we investigated these relationships as part of the JDCP study, a nationwide study launched in 2007. A total of 1477 persons with T2D aged 40-75 years completed a brief self-administered Diet History Questionnaire at baseline, and resultant data were analyzed. Primary outcome was the 7-year risk of a CVD event. Hazard ratios (HRs) for CVD according to tertiles of dietary potassium and sodium intake were estimated by Cox regression adjusted for confounders in addition to a stratified analysis of tertiles of sodium intake. Mean daily potassium and sodium intakes in tertiles 1 to 3 were 1.9, 2.6, and 3.5 g and 3.3, 4.2, and 5.3 g, respectively. HbA1c, BMI, triglycerides, and blood pressure were well controlled. No significant associations between potassium and sodium intakes and incidence of CVD were shown for the second and third tertiles relative to the first tertile (potassium: 0.64 [95% CI, 0.34-1.23] and 0.59 [0.28-1.25]; sodium: 1.02 [0.51-2.04] and 1.15 [0.58-2.30]). In the stratified analysis of tertiles of sodium intake, in the high sodium intake groups (T2 and T3) HRs for CVD in the high potassium intake group were significantly lower compared to the low potassium intake group (T2: 0.40 [0.12-1.35] and 0.06 [0.01-0.69]; T3: 0.23 [0.07-0.82] and 0.26 [0.07-0.88]). Associations of potassium intake with CVD in those with low sodium intake (T1) were not significant. Findings suggested that high potassium intake under high sodium intake is associated with a deceased incidence of CVD in persons with T2D although potassium intake under low sodium intake was not associated with incident CVD.

Disclosure

C.Horikawa: None. H.Shimano: None. J.Satoh: None. Y.Hayashino: Advisory Panel; Novo Nordisk A/S, Ono Pharmaceutical Co., Ltd., Speaker's Bureau; Boehringer Ingelheim Japan, Inc., Sumitomo Dainippon Pharma Co., Ltd., Santen, Daiichi Sankyo, Kowa Company, Ltd. N.Tajima: None. R.Nishimura: Speaker's Bureau; Sanofi K.K., Medicure Inc., Boehringer Ingelheim Inc., Takeda Pharmaceutical Company Limited, Kissei Pharmaceutical Co., Ltd., Novartis Pharma K.K., Eli Lilly Japan K.K., Novo Nordisk, Merck & Co., Inc., Abbott Japan Co., Ltd., Astellas Pharma Inc., Teijin Pharma Limited, Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., AstraZeneca. Y.Yamasaki: None. H.Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kyowa Kirin Co., Ltd., Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., Eisai Co., Ltd., Takeda Pharmaceutical Co., Ltd. Jdcp study group: n/a. M.Takahara: None. N.Katakami: Speaker's Bureau; Abbott Japan Co., Ltd., Daiichi Sankyo, MSD, Mitsubishi Tanabe Pharma Corporation, Kowa Company, Ltd., Ono Pharmaceutical Co., Ltd., Novo Nordisk, Sumitomo Dainippon Pharma Co., Ltd., Bayer Inc., Lilly, Teijin Pharma Limited, Kyowa Kirin Co., Ltd., Boehringer Ingelheim Japan, Inc., Sanofi. Y.Takeda: None. M.Takeuchi: None. K.Fujihara: None. H.Suzuki: None. K.Tsuda: None. N.Yoshioka: None.

DOI： 10.2337/db23-1381-p

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1713-P: Dietary Manganese (Mn) Intake Is Independently Associated with a Lower BMI in Younger Japanese with Type 2 Diabetes Mellitus (T2DM)

LAY MON KHIN, KAZUYA FUJIHARA, MARIKO HATTA, YASUNAGA TAKEDA, SAKIKO Y. MORIKAWA, CHIKA HORIKAWA, NORIKO KATO, MITSUTOSHI KATO, HIROSHI MAEGAWA, HIROHITO SONE

Diabetes 72 ( Supplement_1 ) 2023.6

Publishing type：Research paper (scientific journal) Publisher：American Diabetes Association

We analyzed the association between dietary Mn intake and obesity measured by BMI after adjustment for intake of nutrients and food groups in people with T2DM in Japan. Participants were 1567 people, 63% male, aged 30 to 89 y who were in the Japan Diabetes Clinical Data Management Study Group (JDDM), one of the largest cohorts of Japanese with diabetes. Intake of food groups was determined by a validated self-administered food frequency questionnaire based on food groups. Obesity was defined as BMI ≥25 kg/m2. Multivariate logistic regression analysis assessed the relationship between quartiles of dietary Mn intake and obesity stratified by age. Participants aged 30 to 89 y were grouped according to the following quartiles for age: 30-54 y, 55-63 y, 64-71 y, and 72-89 y. Compared to the lowest quartile (Q1) for Mn, a significant negative association between Mn and BMI was found in males for all quartiles of Mn (OR [95%CI] of Q2= 0.643 [0.424 - 0.973], Q3= 0.607 [0.374 - 0.986], Q4= 0.398 [0.218 - 0.728], p trend = 0.028) with adjustment for characteristics such as age, sex, current smoking, drinking, insulin, oral hypoglycemic agents treatment, activity, energy intake and macronutrients intake. However, statistical significance disappeared after adding total fiber as a covariate. Compared to the lowest quartile for Mn, the highest quartile of Mn was inversely associated with BMI in the younger age group (30-54 y [OR= 0.296 [0.088 - 0.996]]) even after total fiber adjustment. Multivariate analysis of food groups (rice, vegetables, soy products) that were highly correlated with Mn as covariates showed that the relationships between Mn intake and obesity were maintained (p trend for rice, vegetables, soy = &lt;0.001, 0.187, 0.010) in all participants. In summary, higher dietary Mn intake was independently associated with a lower BMI, especially in the younger group and males. Future prospective or intervention studies are expected to confirm this result.

Disclosure

L.Khin: None. H.Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kyowa Kirin Co., Ltd., Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., Eisai Co., Ltd., Takeda Pharmaceutical Co., Ltd. Jddm study group: n/a. K.Fujihara: None. M.Hatta: None. Y.Takeda: None. S.Y.Morikawa: None. C.Horikawa: None. N.Kato: None. M.Kato: None. H.Maegawa: None.

DOI： 10.2337/db23-1713-p

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738-P: Lifestyle Intervention Program with Smartphone App Augmented by Intermittently Scanned Continuous Glucose Monitoring for People at High Risk of Diabetes—Randomized Controlled Trial

MASARU KITAZAWA, HIROSHI SUZUKI, CHIKA HORIKAWA, YASUNAGA TAKEDA, IZUMI IKEDA, MARIKO HATTA, MIDORI IWANAGA, TAKAHO YAMADA, KAZUYA FUJIHARA, HIROHITO SONE

Diabetes 72 ( Supplement_1 ) 2023.6

Publishing type：Research paper (scientific journal) Publisher：American Diabetes Association

We examined the effects of a lifestyle intervention program with a smartphone app augmented by intermittently scanned continuous glucose monitoring (isCGM) of persons at high risk of developing diabetes in a 12-week randomized open-label trial (UMIN00004640). The program monitored blood glucose fluctuations and lifestyle habits and displayed them in an easy-to-understand interface as well as provided personalized lifestyle intervention messages. The primary endpoint was the change in time in range (TIR) of 70-140 mg/dL between intervention (App) and control (C) groups. Among 168 patients (mean age 48.1 y, mean BMI 26.6 kg/m2, and male 80.4%), 82 and 86 were assigned to the App group and C group, respectively. After 12 weeks, TIR of 70-140 mg/dL significantly improved in the App group compared to the C group (-2.6 min/day vs. +31.5 min/day, p=0.03). Changes in time above range (&gt;140 mg/dL; -20.9 min/day vs. -22.6 min/day, p=0.86) did not differ, whereas time below range (&lt;70 mg/dL; +23.5 min/day vs. -8.9 min/day, p=0.02) improved in App compared to C. BMI (-0.26 vs. -0.59, p=0.017) and carbohydrate intake (-4.4 kcal/day vs. -22.7 kcal/day, p=0.049) also improved in App compared to C. Intervention with a smartphone app and isCGM increased glycemic control with a decrease in carbohydrate intake and weight loss.

 Disclosure

M.Kitazawa: None. H.Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kyowa Kirin Co., Ltd., Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., Eisai Co., Ltd., Takeda Pharmaceutical Co., Ltd. H.Suzuki: None. C.Horikawa: None. Y.Takeda: None. I.Ikeda: None. M.Hatta: None. M.Iwanaga: None. T.Yamada: None. K.Fujihara: None.

DOI： 10.2337/db23-738-p

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Recent updates in factors associated with incidence and screening of diabetic eye disease

Hirohito Sone

Journal of Diabetes Investigation 2023.6

中学生におけるスクリーンタイムがボディイメージの歪みと精神的健康度へ及ぼす影響

池田和泉, 藤原和哉, 森川咲子, 武田安永, 石黒創, 堀川千嘉, 山田貴穂, 小川洋平, 曽根博仁

日本内分泌学会雑誌 99 ( 1 ) 333 - 333 2023.5

The Reply

Ryoko Kawakami, Kiminori Kato, Hirohito Sone

The American Journal of Medicine 136 ( 5 ) e104 - e104 2023.5

ヘパプラスチンテストを取り入れた出血原因鑑別の検査戦略後天性第V因子欠乏症における経験

松田将門, 山田隆, 古山悠里, 柴崎康彦, 関義信, 星山良樹, 寺井崇二, 瀧澤淳, 曽根博仁, 増子正義

日本血栓止血学会誌 34 ( 2 ) 262 - 262 2023.5

Incidence and predictors of remission and relapse of type 2 diabetes mellitus in Japan: Analysis of a nationwide patient registry Reviewed International journal

Hirohito Sone

Diabetes, Obesity and Metabolism 25 ( 8 ) 2227 - 2235 2023.5

Reduced incidence of cardiovascular disease in patients with type 2 diabetes through the integrated improvement of diabetes care by comparing two prospective observational cohorts in real-world clinical practice (JDDM 72) International journal

Hirohito Sone

Diabetes Research and Clinical Practice 202 110674 - 110674 2023.4

耐糖能や年齢で層別化した血清アミラーゼ低値およびその経時的減少が2型糖尿病発症に及ぼす影響の縦断的検討

池田和泉, 藤原和哉, 大澤妙子, 武田安永, 治田麻里子, 松林泰弘, 児玉暁, 森保道, 本田律子, 門脇孝, 荒瀬康司, 曽根博仁

糖尿病 66 ( Suppl.1 ) S - 215 2023.4

日本人ビッグデータにより血糖を含む全構成項目閾値を心血管疾患予測に最適化した新メタボリックシンドローム基準の有用性評価

三ツ間友里恵, 藤原和哉, 山田万祐子, 村井幸四郎, 佐藤隆明, 矢口雄大, 山本正彦, 大澤妙子, 北澤勝, 松林泰弘, 岩永みどり, 山田貴穂, 曽根博仁

糖尿病 66 ( Suppl.1 ) S - 172 2023.4

糖尿病/高血圧/肥満と脂肪肝との関連が心不全発症に与える影響についての検討

松林泰弘, 藤原和哉, 山田万祐子, 佐藤隆明, 矢口雄大, 山本正彦, 石黒創, 大澤妙子, 北澤勝, 岩永みどり, 山田貴穂, 曽根博仁

糖尿病 66 ( Suppl.1 ) S - 174 2023.4

JDDM登録患者4万8千人の2型糖尿病患者における新たに定義された世界共通定義による寛解(remission)の発生頻度と関連因子

藤原和哉, 松林泰弘, 佐藤隆明, 山田万祐子, 矢口雄大, 大澤妙子, 岩永みどり, 山崎勝也, 前川聡, 山田貴穂, 曽根博仁

糖尿病 66 ( Suppl.1 ) S - 194 2023.4

糖尿病(DM)に5つの生活習慣関連因子(Cardiovascular Health Metrics)不良を伴うと腎透析導入(HD)リスクは著明に上昇する

大澤妙子, 藤原和哉, 山田万祐子, 矢口雄大, 佐藤隆明, 北澤勝, 松林泰弘, 山田貴穂, 曽根博仁

糖尿病 66 ( Suppl.1 ) S - 197 2023.4

新規に開発された体力指標フィジカルスコアによるメタボリックシンドローム発症予測能の検討

佐藤隆明, 藤原和哉, 山田万由子, 張かおり, 矢口雄大, 山本正彦, 北澤勝, 石黒創, 大澤妙子, 山田貴穂, 加藤公則, 曽根博仁

糖尿病 66 ( Suppl.1 ) S - 309 2023.4

Network meta-analysis of glucose-lowering drug treatment regimens with the potential risk of hypoglycemia in patients with type 2 diabetes mellitus in terms of glycemic control and severe hypoglycemia Reviewed

Hirohito Sone

Journal of Investigative Medicine 2023.4

写真撮影とAIを活用した食事記録スマートフォンアプリによる日常の食事記録の妥当性検証

北澤勝, 堀川千嘉, 長谷川美代, 武田安永, 治田麻理子, 松林泰弘, 山田貴穂, 児玉暁, 藤原和哉, 曽根博仁

糖尿病 66 ( Suppl.1 ) S - 230 2023.4

コンドロイチン硫酸と糖尿病性神経障害の関連の検討

石黒創, 牛木隆志, 五十嵐道弘, 曽根博仁

新潟県医師会報 ( 877 ) 12 - 14 2023.4

Utility of a Physical Fitness Score in Screening for Chronic Diseases International journal

Hirohito Sone

Journal of Sports Science and Medicine 22 ( 1 ) 98 - 110 2023.3

炭水化物エネルギー比率の算出方法の違いは、糖尿病患者の炭水化物エネルギー比率と心血管疾患発症リスクの関係に影響しうるか

堀川千嘉, 高原充佳, 片上直人, 武田安永, 竹内瑞希, 藤原和哉, 鈴木浩明, 津田謹輔, 吉岡成人, 押田芳治, 島野仁, 佐藤譲, 林野泰明, 田嶼尚子, 西村理明, 山崎義光, 曽根博仁

日本栄養・食糧学会大会講演要旨集 77回 314 - 314 2023.3

Risk of fetal undergrowth in the management of gestational diabetes mellitus in Japan

Hirohito Sone

Journal of Diabetes Investigation 2023.2

妊娠初期における母体のヘモグロビン値・赤血球恒数と低出生体重児出産との関連の検討

谷内洋子, 坂本莉菜, 柴崎康彦, 山田貴穂, 生魚薫, 柳生田紀子, 龍野一郎, 曽根博仁

Journal of Epidemiology 33 ( Suppl.1 ) 146 - 146 2023.2

エンフォルツマブによる高血糖と回腸導管による代謝性アシドーシスの1例

浅島雄弥, 佐藤隆明, 佐々木知佳, 鈴木浩史, 岩永みどり, 山田貴穂, 藤原和哉, 曾根博仁

新潟医学会雑誌 137 ( 2 ) 71 - 71 2023.2

エンフォルツマブによる高血糖と回腸導管による代謝性アシドーシスの1例

浅島雄弥, 佐藤隆明, 佐々木知佳, 鈴木浩史, 岩永みどり, 山田貴穂, 藤原和哉, 曾根博仁

新潟医学会雑誌 137 ( 2 ) 71 - 71 2023.2

ソフトドリンクケトーシス治療中に腎性尿崩症が指摘された一例

日向裕大, 矢口雄大, 砂田大介, 川井千尋, 山本正彦, 石黒創, 北澤勝, 石澤正博, 鈴木浩史, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

日本内分泌学会雑誌 98 ( 4 ) 856 - 856 2023.2

Combined effects of blood pressure and glycemic status on risk of heart failure: a population-based study

Hirohito Sone

Journal of Hypertension Publish Ahead of Print 2023.1

オンライン予防歯科教育動画による企業従業員のヘルスリテラシー向上と行動変容における有効性の検証

植木麻有子, 田村浩平, 木村大地, 木村美樹, 曽根博仁, 小川祐司

口腔衛生学会雑誌 73 ( 1 ) 64 - 64 2023.1

Association of the estimated glomerular filtration rate (eGFR) and/or proteinuria to predict the risk of initiation of dialysis in people with and without diabetes

Hirohito Sone

Diabetology International 14 ( 1 ) 86 - 93 2023.1

Hypoglycemic Hemiplegia Associated with Reversible Narrowing of the Contralateral Middle Cerebral Artery in a Patient with Adrenal Insufficiency

Hirohito Sone

Internal Medicine 2023

Machine Learning Approach to Drug Treatment Strategy for Diabetes Care

Hirohito Sone

Diabetes & Metabolism Journal 2023

Prediction and prevention of the onset of hypertension from the viewpoint of estimated 24-hour salt excretion and physical fitness test

Hirohito Sone

Journal of Hypertension 2023

Relationship between changes in blood pressure from summer to winter and estimated 24-hour salt excretion using spot urine: the Niigata Wellness Study

Hirohito Sone

Hypertension Research 2023

Effect of dietary fiber-enriched brown rice crackers on suppressing elevation of blood glucose level

Hiroshi Suzuki, Kenichi Watanabe, Izumi Ikeda, Yasunaga Takeda, Mariko Hatta, Chika Horikawa, Efrem D’Avila Ferreira, Wu Sijia, Khin Laymon, Hirohito Sone

Functional Foods in Health and Disease 13 ( 11 ) 595 - 604 2023

Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis

Nurani Istiqamah, Takashi Matsuzaka, Momo Shimizu, Kaori Motomura, Hiroshi Ohno, Shiho Hasebe, Rahul Sharma, Yuka Okajima, Erika Matsuda, Song-Iee Han, Yuhei Mizunoe, Yoshinori Osaki, Yuichi Aita, Hiroaki Suzuki, Hirohito Sone, Yoshinori Takeuchi, Motohiro Sekiya, Naoya Yahagi, Yoshimi Nakagawa, Hitoshi Shimano

BBA Advances 3 100078 - 100078 2023

Machine learning approach to predict body weight in adults International journal

Hirohito Sone

Frontiers in Public Health 11 1090146 - 1090146 2023

Citrate synthase insufficiency leads to specific metabolic adaptations in the heart and skeletal muscles upon low-carbohydrate diet feeding in mice(vol 9, 925908, 2022)

Hirohito Sone

Frontiers in Nutrition 9 2023

Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease. International journal

Masaya Araki, Yoshimi Nakagawa, Hodaka Saito, Yasunari Yamada, Song-Iee Han, Yuhei Mizunoe, Hiroshi Ohno, Takafumi Miyamoto, Motohiro Sekiya, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano

American journal of physiology. Gastrointestinal and liver physiology 323 ( 6 ) G627-G639 2022.12

乳酸醗酵酒粕の非アルコール性脂肪性肝炎の進行抑制効果

鈴木浩史, 渡辺賢一, Arumugam Somasundaram, Afrin Rejina, 松林泰弘, 曽根博仁

機能性食品と薬理栄養 16 ( 3 ) 191 - 191 2022.12

デキサメタゾン投与後に周期性四肢麻痺を呈したバセドウ病の一例

浅島雄弥, 佐藤隆明, 滝澤大輝, 日向裕大, 今西明, 橋本浩平, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

日本内分泌学会雑誌 98 ( 2 ) 583 - 583 2022.10

Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4–FGF21 Signaling in Mouse Hepatocyte AML12 Cells

Yasunari Yamada, Hodaka Saito, Masaya Araki, Yuhei Tsuchimoto, Shin-ichi Muroi, Kyohei Suzuki, Kazufumi Toume, Jun-Dal Kim, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano, Yoshimi Nakagawa

Nutrients 14 ( 19 ) 3920 - 3920 2022.9

YAP1/TAZ activity maintains vascular integrity and organismal survival. International journal

Shun Uemura, Masayuki Yamashita, Kazumasa Aoyama, Takako Yokomizo-Nakano, Motohiko Oshima, Miki Nishio, Masayoshi Masuko, Jun Takizawa, Hirohito Sone, Yasuhiro Yamada, Akira Suzuki, Atsushi Iwama

Biochemical and biophysical research communications 619 117 - 123 2022.9

握力、閉眼片足立ち、立位体前屈による総合体力指標はメタボリックシンドロームの発症予測に有用である

佐藤隆明, 藤原和哉, 山田万祐子, 張かおり, 矢口雄大, 山本正彦, 北澤勝, 石黒創, 大澤妙子, 山田貴穂, 加藤公則, 曽根博仁

日本臨床運動療法学会学術集会プログラム・抄録集 41回 57 - 57 2022.9

耐糖能およびHDL-C値によるLDL-C値が冠動脈疾患発症に及ぼす影響の検討

山田万祐子, 藤原和哉, 大澤妙子, 北澤勝, 松林泰弘, 矢口雄大, 山本正彦, 佐藤隆明, 三ツ間友里恵, 岩永みどり, 山田貴穂, 児玉暁, 曽根博仁

糖尿病合併症 36 ( Suppl.1 ) 173 - 173 2022.9

糖尿病性ケトアシドーシス治療中に腎性尿崩症が指摘された一例

日向裕大, 矢口雄大, 砂田大介, 川井千尋, 山本正彦, 石黒創, 北澤勝, 石澤正博, 鈴木浩史, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

新潟医学会雑誌 136 ( 9 ) 303 - 303 2022.9

尿細管障害を伴う低カリウム血症の加療中にデノスマブによる著明な低Ca血症をきたした1例

砂田大介, 矢口雄大, 川井千尋, 日向裕大, 山本正彦, 石黒創, 北澤勝, 石澤正博, 鈴木浩史, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

新潟医学会雑誌 136 ( 9 ) 303 - 303 2022.9

尿細管障害を伴う低カリウム血症の加療中にデノスマブによる著明な低Ca血症をきたした1例

砂田大介, 矢口雄大, 川井千尋, 日向裕大, 山本正彦, 石黒創, 北澤勝, 石澤正博, 鈴木浩史, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

新潟医学会雑誌 136 ( 9 ) 303 - 303 2022.9

糖尿病性ケトアシドーシス治療中に腎性尿崩症が指摘された一例

日向裕大, 矢口雄大, 砂田大介, 川井千尋, 山本正彦, 石黒創, 北澤勝, 石澤正博, 鈴木浩史, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

新潟医学会雑誌 136 ( 9 ) 303 - 303 2022.9

成長ホルモン産生下垂体腺腫に対する発現受容体分類に基づく治療の可能性

岡田正康, 米岡有一郎, 大石誠, 石黒創, 山本正彦, 大澤妙子, 伊藤崇子, 曽根博仁, 藤井幸彦

新潟医学会雑誌 136 ( 9 ) 302 - 302 2022.9

Predictors of hemoglobin and its changes focusing on anemia and polycythemia after administration of the SGLT2 inhibitor, tofogliflozin. International journal

Yasuhiro Matsubayashi, Akihiro Yoshida, Hideki Suganami, Momoko Oe, Takaaki Sato, Yuta Yaguchi, Kazuya Fujihara, Takaho Yamada, Shiro Tanaka, Kohei Kaku, Hirohito Sone

Diabetes, obesity & metabolism 24 ( 12 ) 2469 - 2473 2022.8

Fast walking and physical activity are independent contributors to improved physical function. International journal

Haruka Shiozaki, Kazuya Fujihara, Mayuko Yamada-Harada, Masahiko Yamamoto, Yurie Mitsuma, Masaru Kitazawa, Yuta Yaguchi, Yasuhiro Matsubayashi, Midori Iwanaga, Takaho Yamada, Satoru Kodama, Hirohito Sone

Family practice 2022.8

Two cases of 22q11.2 deletion syndrome with decreased serum calcium during recovery following thyrotoxicosis. International journal

Shota Hiroshima, Chihiro Taniguchi, Mika Inoue, Hirohito Sone, Keisuke Nagasaki

Congenital anomalies 2022.8

Effect of heat-moisture treated brown rice crackers on postprandial flow-mediated dilation in adults with mild endothelial dysfunction. International journal

Kenichi Watanabe, Masao Hirayama, Somasundaram Arumugam, Masayoshi Sugawara, Hisanori Kato, Sumiko Nakamura, Ken'ichi Ohtsubo, Hitoshi Matsumoto, Yuri Nomi, Noriyuki Homma, Yoshifumi Fujii, Naoto Murohashi, Rajarajan A Thandavarayan, Hiroshi Suzuki, Kazuya Fujihara, Satoru Kodama, Hirohito Sone

Heliyon 8 ( 8 ) e10284 2022.8

Association between Obesity and Intake of Different Food Groups among Japanese with Type 2 Diabetes Mellitus—Japan Diabetes Clinical Data Management Study (JDDM68) International journal

Mariko Hatta, Chika Horikawa, Yasunaga Takeda, Izumi Ikeda, Sakiko Yoshizawa Morikawa, Noriko Kato, Mitsutoshi Kato, Hiroki Yokoyama, Yoshio Kurihara, Hiroshi Maegawa, Kazuya Fujihara, Hirohito Sone

Nutrients 14 ( 15 ) 2022.7

生活習慣・栄養分野におけるガイドライン2022のトピックスと今後の課題脂質改善・動脈硬化予防のための運動・身体活動

木庭新治, 曽根博仁, 児玉暁, 藤原和哉, 横田裕哉, 宮下政司, 井上茂

日本動脈硬化学会総会プログラム・抄録集 54回 151 - 151 2022.7

Impact of metabolic syndrome and metabolic dysfunction-associated fatty liver disease on cardiovascular risk by the presence or absence of type 2 diabetes and according to sex. International journal

Yasuhiro Matsubayashi, Kazuya Fujihara, Mayuko Yamada-Harada, Yurie Mitsuma, Takaaki Sato, Yuta Yaguchi, Taeko Osawa, Masahiko Yamamoto, Masaru Kitazawa, Takaho Yamada, Satoru Kodama, Hirohito Sone

Cardiovascular diabetology 21 ( 1 ) 90 - 90 2022.6

【健康食品・機能性食品による健康障害の防止】わが国の健康食品やサプリメントによる重篤な有害事象内科学会症例報告データベースにおける検討

鈴木浩史, 渡辺賢一, 山本正彦, 武田安永, 治田麻理子, 堀川千嘉, 藤原和哉, 曽根博仁

機能性食品と薬理栄養 15 ( 6 ) 297 - 303 2022.6

J-EDIT・JDCSの合同解析による、年代別に見た日本人2型糖尿病患者の食塩摂取量と心血管疾患発症の縦断的検討

堀川千嘉, 池田和泉, 相田麗, 田中司朗, 鎌田智恵実, 吉村幸雄, 藤原和哉, 井藤英喜, 赤沼安夫, 守屋達美, 荒木厚, 曽根博仁

日本栄養・食糧学会大会講演要旨集 76回 231 - 231 2022.5

Differences in occupational stress by smoking intensity and gender in cross-sectional study of 59 355 Japanese employees using the Brief Job Stress Questionnaire (BJSQ): the Niigata Wellness Study

Hirohito Sone

BMJ Open 2022.4

青少年におけるスマートフォンを含むスクリーンタイムと肥満との関連

池田和泉, 藤原和哉, 森川咲子, 武田安永, 石黒創, 山田万祐子, 堀川千嘉, 松林泰弘, 山田貴穂, 曽根博仁

日本内分泌学会雑誌 98 ( 1 ) 296 - 296 2022.4

小児における睡眠時間およびソーシャルジェットラグと過体重・肥満の関連

塩崎悠香, 藤原和哉, 山田万祐子, 大澤妙子, 北澤勝, 松林泰弘, 矢口雄大, 山本正彦, 佐藤隆明, 山田貴穂, 曽根博仁

日本内分泌学会雑誌 98 ( 1 ) 296 - 296 2022.4

新たな総合体力指標を用いたメタボリックシンドロームの発症予測能の検討

佐藤隆明, 藤原和哉, 山田万祐子, 張かおり, 矢口雄大, 山本正彦, 北澤勝, 石黒創, 大澤妙子, 山田貴穂, 加藤公則, 曽根博仁

糖尿病 65 ( Suppl.1 ) S - 155 2022.4

耐糖能およびHDLコレステロール値別にみたLDLコレステロールが冠動脈疾患に及ぼす影響の検討

山田万祐子, 藤原和哉, 大澤妙子, 北澤勝, 松林泰弘, 矢口雄大, 山本正彦, 佐藤隆明, 三ツ間友里恵, 岩永みどり, 山田貴徳, 児玉暁, 曽根博仁

糖尿病 65 ( Suppl.1 ) S - 186 2022.4

HDLコレステロール値別にみたLDLコレステロールと冠動脈疾患との関連

山田万祐子, 藤原和哉, 大澤妙子, 北澤勝, 松林泰弘, 矢口雄大, 山本正彦, 佐藤隆明, 三ツ間友里恵, 岩永みどり, 山田貴穂, 児玉暁, 曽根博仁

日本内分泌学会雑誌 98 ( 1 ) 322 - 322 2022.4

AHA Life's simple 7に基づく腎透析導入リスクの予測

大澤妙子, 藤原和哉, 山田万祐子, 矢口雄大, 佐藤隆明, 北澤勝, 松林泰弘, 山田貴穂, 曽根博仁

糖尿病 65 ( Suppl.1 ) S - 142 2022.4

Dietary intake and physical activity in Japanese patients with type 2 diabetes: the Japan Diabetes Complication and its Prevention prospective study (JDCP study 8).

Chika Horikawa, Kinsuke Tsuda, Yoshiharu Oshida, Jo Satoh, Yasuaki Hayashino, Naoko Tajima, Rimei Nishimura, Hirohito Sone

Diabetology international 13 ( 2 ) 344 - 357 2022.4

日本人2型糖尿病患者における、年齢層別に見た食塩摂取量と心血管疾患発症との関係 J-EDIT・JDCSの解析から

堀川千嘉, 相田麗, 田中司朗, 鎌田智英実, 田中佐知子, 吉村幸雄, 小寺玲美, 藤原和哉, 守屋達美, 井藤英喜, 赤沼安夫, 荒木厚, 曽根博仁

糖尿病 65 ( Suppl.1 ) S - 142 2022.4

日本人2型糖尿病患者における食品群摂取量と肥満の関連 JDDMにおける検討

治田麻理子, 堀川千嘉, 武田安永, 池田泉, 森川咲子, 加藤則子, 加藤光敏, 横山宏樹, 栗原義夫, 前川聡, 藤原和哉, 曽根博仁, 糖尿病データマネジメント研究会

糖尿病 65 ( Suppl.1 ) S - 131 2022.4

妊娠中期における糖代謝状態と低出生体重児出産との関連の検討

谷内洋子, 山田貴穂, 藤原和哉, 生魚薫, 堀川千嘉, 田中康弘, 龍野一郎, 曽根博仁

糖尿病 65 ( Suppl.1 ) S - 214 2022.4

肥満における各野菜摂取頻度と遺伝子・環境相互作用の検討

藤原和哉, 野川駿, 齋藤憲司, 堀川千嘉, 武田安永, 張かおり, 石黒創, 児玉暁, 曽根博仁

糖尿病 65 ( Suppl.1 ) S - 160 2022.4

アレルギーの食餌制限によりヨード欠乏症を来した成人男性の一例

滝澤大輝, 日向裕大, 橋本浩平, 松林泰弘, 岩永みどり, 山田貴穂, 藤原和哉, 長崎啓祐, 曽根博仁

日本内分泌学会雑誌 98 ( 1 ) 349 - 349 2022.4

肥満傾向または肥満を合併した2型糖尿病高リスクを有する男性に対する血糖自己測定SMBGと栄養教育ツールを併用した栄養教育の効果

長谷川美代, 堀川千嘉, 田代稔, 鈴木沙織, 藤原和哉, 北澤勝, 加藤公則, 田中司朗, 曽根博仁

日本栄養士会雑誌 65 ( 3 ) 159 - 168 2022.3

Leisure-time physical activity and incidence of objectively assessed hearing loss: The Niigata Wellness Study. International journal

Ryoko Kawakami, Susumu S Sawada, Kiminori Kato, Yuko Gando, Haruki Momma, Hideaki Oike, Motohiko Miyachi, I-Min Lee, Minoru Tashiro, Chika Horikawa, Hajime Ishiguro, Yasuhiro Matsubayashi, Kazuya Fujihara, Hirohito Sone

Scandinavian journal of medicine & science in sports 32 ( 2 ) 435 - 445 2022.2

Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice. International journal

Yuka Okajima, Takashi Matsuzaka, Shun Miyazaki, Kaori Motomura, Hiroshi Ohno, Rahul Sharma, Takuya Shimura, Nurani Istiqamah, Song-Iee Han, Yuhei Mizunoe, Yoshinori Osaki, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Hirohito Sone, Takafumi Miyamoto, Yuichi Aita, Yoshinori Takeuchi, Motohiro Sekiya, Naoya Yahagi, Yoshimi Nakagawa, Tsutomu Tomita, Hitoshi Shimano

Biochimica et biophysica acta. Molecular basis of disease 1868 ( 4 ) 166339 - 166339 2022.1

Higher Iron Intake Is Independently Associated with Obesity in Younger Japanese Type-2 Diabetes Mellitus Patients International journal

Efrem d'Ávila, Mariko Hatta, Yasunaga Takeda, Chika Horikawa, Mizuki Takeuchi, Noriko Kato, Hiroki Yokoyama, Yoshio Kurihara, Koichi Iwasaki, Kazuya Fujihara, Hiroshi Maegawa, Hirohito Sone

Nutrients 14 ( 1 ) 2022.1

耐糖能別おける収縮期血圧と冠動脈疾患(CAD)/脳血管疾患発症(CVD)の関連

藤原和哉, 山田万祐子, 山本正彦, 松林泰弘, 北澤勝, 石澤正博, 堀川千嘉, 児玉暁, 曽根博仁

Journal of Epidemiology 32 ( Suppl.1 ) 128 - 128 2022.1

妊娠中期における母体のインスリン値と低出生体重児出産との関連の検討

谷内洋子, 藤原和哉, 堀川千嘉, 生魚薫, 山本正彦, 石澤正博, 山田貴穂, 児玉暁, 曽根博仁

Journal of Epidemiology 32 ( Suppl.1 ) 142 - 142 2022.1

Evaluation of a Comprehensive Physical Fitness Index to Predict Future Prediabetes and Metabolic Syndrome (MetS)

Hirohito Sone

Diabetes 2022

Impact of Health Factors on Incident Cardiovascular Disease (CVD) According to Glucose Tolerance Status

Hirohito Sone

Diabetes 2022

Impact of Medication Adherence (MA) to Oral Glycemic Agents (OHAs) on Initiation of Dialysis in Patients with Moderately Impaired Renal Function

Hirohito Sone

Diabetes 2022

Combined Severe Diabetic Complications: The New Life-Altering Outcome

Hirohito Sone

Diabetes 2022

Breadth of the Human Leukocyte Antigens Class I Immunopeptidome in Allogenic Hematopoietic Stem Cell Transplantation Outcomes for Myeloid Malignancy

Hirohito Sone

Blood 2022

HLA-B Leader Mismatch Positively Correlates with Survival Rate in Haplo and Cord Blood Transplantation for Acute Leukemia in Japanese Patients

Hirohito Sone

Blood 2022

Associations of Systolic Blood Pressure (SBP) with the Incidence of Heart Failure (HF) According to Glucose Tolerance Status (GTS)

Hirohito Sone

Diabetes 2022

Network Meta-analysis of Hypoglycemic Treatment Regimens with Potential Risk of Hypoglycemia in Terms of Glycemic Control and Severe Hypoglycemia

Hirohito Sone

Diabetes 2022

Sex Differences in the Effect of High Serum Uric Acid on the Incidence of Vision-Threatening Retinopathy in Those with Type 2 Diabetes

Hirohito Sone

Diabetes 2022

Impact of Metabolic Syndrome and Metabolic Dysfunction-Associated Fatty Liver Disease on Cardiovascular Risk in People with and without Type 2 Diabetes

Hirohito Sone

Diabetes 2022

Meal Ingestion of Ceraceomyces tessulatus Strain BDM-X (Agaricomycetes) Protects against Nonalcoholic Steatohepatitis in Mice

Hirohito Sone

International Journal of Medicinal Mushrooms 2022

Association between Sleep Duration, Bedtime, and Hyperglycemia or Overweight/Obesity among Japanese Children

Hirohito Sone

Diabetes 2022

Use of American Heart Association's "Life's Simple 7" as a Predictor for Initiation of Dialysis

Hirohito Sone

Diabetes 2022

Citrate Synthase Insufficiency Leads to Specific Metabolic Adaptations in the Heart and Skeletal Muscles Upon Low-Carbohydrate Diet Feeding in Mice

Hirohito Sone

Frontiers in Nutrition 2022

XGBoost: Interpretable Machine Learning Approach in Medicine

Jenny Price, Tatsuya Yamazaki, Kazuya Fujihara, Hirohito Sone

WSCE 2022 - 2022 5th World Symposium on Communication Engineering 109 - 113 2022

Predictive ability of current machine learning algorithms for type 2 diabetes mellitus: A meta-analysis.

Satoru Kodama, Kazuya Fujihara, Chika Horikawa, Masaru Kitazawa, Midori Iwanaga, Kiminori Kato, Kenichi Watanabe, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano, Hirohito Sone

Journal of diabetes investigation 13 ( 5 ) 900 - 908 2021.12

Impact of prior cerebrovascular disease and glucose status on incident cerebrovascular disease in Japanese International journal

Momoko Oe, Kazuya Fujihara, Mayuko Harada-Yamada, Taeko Osawa, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaaki Sato, Yuta Yaguchi, Midori Iwanaga, Hiroyasu Seida, Takaho Yamada, Hirohito Sone

Cardiovascular Diabetology 20 ( 1 ) 174 - 174 2021.12

マウスにおける越後白雪茸の摂取による非アルコール性脂肪性肝炎の進行抑制効果

鈴木浩史, 渡辺賢一, Arumugam Somasundaram, Yellurkar Manoj Limbraj, Sreedhar Remya, Afrin Rejina, 曽根博仁

機能性食品と薬理栄養 15 ( 3 ) 184 - 184 2021.12

Impact of Medication Adherence and Glycemic Control on the Risk of Micro- and Macrovascular Diseases in Patients with Diabetes. International journal

Yuta Yaguchi, Kazuya Fujihara, Mayuko Harada Yamada, Yasuhiro Matsubayashi, Takaho Yamada, Midori Iwanaga, Masaru Kitazawa, Masahiko Yamamoto, Hiroyasu Seida, Satoru Kodama, Hirohito Sone

The American journal of medicine 135 ( 4 ) 461 - 470 2021.11

イノツズマブによる再寛解導入に引き続いてブリナツモマブを投与し再移植できたB-ALLの1例

米澤穂高, 布施香子, 水戸部正樹, 武田るい, 諏訪部達也, 片桐隆幸, 柴崎康彦, 瀧澤淳, 成田美和子, 曽根博仁, 増子正義

臨床血液 62 ( 10 ) 1526 - 1526 2021.10

Comparing Associations of Dietary Energy Density and Energy Intake, Macronutrients with Obesity in Patients with Type 2 Diabetes (JDDM 63). International journal

Yasunaga Takeda, Kazuya Fujihara, Rina Nedachi, Izumi Ikeda, Sakiko Yoshizawa Morikawa, Mariko Hatta, Chika Horikawa, Mitsutoshi Kato, Noriko Kato, Hiroki Yokoyama, Yoshio Kurihara, Kazuhiro Miyazawa, Hiroshi Maegawa, Hirohito Sone

Nutrients 13 ( 9 ) 2021.9

Altered Microbiota by a High-Fat Diet Accelerates Lethal Myeloid Hematopoiesis Associated with Systemic Socs3 Deficiency International journal

Kaori Cho, Takashi Ushiki, Hajime Ishiguro, Suguru Tamura, Masaya Araki, Tatsuya Suwabe, Takayuki Katagiri, Mari Watanabe, Yoko Fujimoto, Riuko Ohashi, Yoichi Ajioka, Ippei Shimizu, Shujiro Okuda, Masayoshi Masuko, Yoshimi Nakagawa, Hideyo Hirai, Warren S. Alexander, Hitoshi Shimano, Hirohito Sone

iScience 24 ( 10 ) 103117 - 103117 2021.9

Carrot Consumption Frequency Associated with Reduced BMI and Obesity through the SNP Intermediary rs4445711 International journal

Kazuya Fujihara, Shun Nogawa, Kenji Saito, Chika Horikawa, Yasunaga Takeda, Kaori Cho, Hajime Ishiguro, Satoru Kodama, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano, Hirohito Sone

Nutrients 13 ( 10 ) 2021.9

Secular Trends in Dietary Intake over a 20-Year Period in People with Type 2 Diabetes in Japan: A Comparative Study of Two Nationwide Registries; Japan Diabetes Complications Study (JDCS) and Japan Diabetes Clinical Data Management Study (JDDM) International journal

Mizuki Takeuchi, Chika Horikawa, Mariko Hatta, Yasunaga Takeda, Rina Nedachi, Izumi Ikeda, Sakiko Yoshizawa Morikawa, Noriko Kato, Hiroki Yokoyama, Rei Aida, Shiro Tanaka, Chiemi Kamada, Yukio Yoshimura, Toshiko Saito, Kazuya Fujihara, Atsushi Araki, Hirohito Sone

Nutrients 13 ( 10 ) 2021.9

WT1ペプチドワクチン投与後のCML患者におけるWT1特異的CTLの持続性と多様性(Persistence and diversity of WT1-specific CTLs in a CML patient vaccinated WT1 peptide)

諏訪部達也, 柴崎康彦, 田村秀, 片桐隆幸, 布施香子, 牛木隆志, 曽根博仁, 成田美和子, 増子正義

日本血液学会学術集会 83回 PS - 1 2021.9

ドナーリンパ球のコンドロイチン硫酸合成低下はGVHDを軽減する(Genetic manipulation resulting in decreased donor chondroitin sulfate mitigates GVHD in mice)

田村秀, 牛木隆志, 諏訪部達也, 片桐隆幸, 石黒創, 布施香子, 柴崎康彦, 進藤岳郎, 五十嵐道弘, 曽根博仁, 増子正義

日本血液学会学術集会 83回 OS3 - 1 2021.9

AMLにおける造血幹細胞移植後1年未満の再発は高い死亡率と相関する(Post-transplant relapse of AML within one year is associated with a high mortality rate)

片桐隆幸, 本宮奈津子, 武田ルイ, 水戸部正樹, 米沢穂高, 諏訪部達也, 布施香子, 柴崎康彦, 瀧澤淳, 曽根博仁, 増子正義

日本血液学会学術集会 83回 PS - 10 2021.9

Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at ER monitoring and regulating fatty acids

Hirohito Sone

BioRxiv 2021.8

Developing a health economic model for Asians with type 2 diabetes based on the Japan Diabetes Complications Study and the Japanese Elderly Diabetes Intervention Trial. International journal

Shiro Tanaka, Jakob Langer, Tim Morton, Nicki Hoskins, Lars Wilkinson, Sachiko Tanaka-Mizuno, Ryo Kawasaki, Tatsumi Moriya, Chika Horikawa, Rei Aida, Atsushi Araki, Kazuya Fujihara, Hirohito Sone

BMJ open diabetes research & care 9 ( 1 ) 2021.8

Intensive oral care can reduce bloodstream infection with coagulase-negative staphylococci after neutrophil engraftment in allogeneic hematopoietic stem-cell transplantation. International journal

Tatsuya Suwabe, Kyoko Fuse, Kouji Katsura, Marie Soga, Takayuki Katagiri, Yasuhiko Shibasaki, Miwako Narita, Hirohito Sone, Masayoshi Masuko

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 30 ( 1 ) 475 - 485 2021.7

Central diabetes insipidus after syndrome of inappropriate antidiuretic hormone secretion with severe hyponatremia in a patient with Rathke's cleft cyst.

Yudai Hinata, Nobumasa Ohara, Takeshi Komatsu, Yuki Sakurai, Yuichiro Yoneoka, Yasuhiro Seki, Katsuhiko Akiyama, Hirohito Sone

Internal medicine (Tokyo, Japan) 61 ( 2 ) 197 - 203 2021.7

Meta-analytic research of the dose-response relationship between salt intake and risk of heart failure. Reviewed International journal

Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Mariko Hatta, Yasunaga Takeda, Rena Nedachi, Kiminori Kato, Kenichi Watanabe, Hirohito Sone

Hypertension research : official journal of the Japanese Society of Hypertension 44 ( 7 ) 885 - 887 2021.7

Association of estimated plasma volume and weight loss after long-term administration and subsequent discontinuation of the sodium-glucose cotransporter-2 inhibitor tofogliflozin. International journal

Yasuhiro Matsubayashi, Akihiro Yoshida, Hideki Suganami, Momoko Oe, Takaaki Sato, Yuta Yaguchi, Kazuya Fujihara, Takaho Yamada, Shiro Tanaka, Kohei Kaku, Hirohito Sone

Diabetes, obesity & metabolism 23 ( 7 ) 1660 - 1665 2021.7

Author Correction: Meta-analytic research of the dose-response relationship between salt intake and risk of heart failure. International journal

Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Mariko Hatta, Yasunaga Takeda, Rena Nedachi, Kiminori Kato, Kenichi Watanabe, Hirohito Sone

Hypertension research : official journal of the Japanese Society of Hypertension 44 ( 7 ) 894 - 894 2021.7

粘液水腫性昏睡に急性膵炎を合併した一例

齋藤啓輔, 矢口雄大, 滝澤祥子, 西井郁生, 竹内亮, 山本正彦, 川田亮, 石黒創, 北澤勝, 松林泰弘, 鈴木浩史, 岩永みどり, 山田貴穂, 藤原和哉, 曽根博仁

日本内分泌学会雑誌 97 ( Suppl.Update ) 38 - 40 2021.7

Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling. International journal

Yoshimi Nakagawa, Kae Kumagai, Song-Iee Han, Yuhei Mizunoe, Masaya Araki, Seiya Mizuno, Hiroshi Ohno, Kazuya Matsuo, Yasunari Yamada, Jun-Dal Kim, Takafumi Miyamoto, Motohiro Sekiya, Morichika Konishi, Nobuyuki Itoh, Takashi Matsuzaka, Satoru Takahashi, Hirohito Sone, Hitoshi Shimano

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 35 ( 6 ) e21663 2021.6

同種造血幹細胞移植後の慢性GVHDとしての類上皮肉芽腫および多発筋炎

諏訪部達也, 布施香子, 水戸部正樹, 武田ルイ, 米沢穂高, 片桐隆幸, 河本啓介, 牛木隆志, 柴崎康彦, 瀧澤淳, 成田美和子, 曽根博仁, 大島孝一, 増子正義

臨床血液 62 ( 6 ) 675 - 675 2021.6

陰茎・陰嚢病変を合併した精巣原発DLBCL

水戸部正樹, 武田ルイ, 米沢穂高, 田村秀, 諏訪部達也, 片桐隆幸, 河本啓介, 布施香子, 柴崎康彦, 増子正義, 井上佳菜子, 三好寛明, 大島孝一, 曽根博仁, 瀧澤淳

臨床血液 62 ( 6 ) 668 - 668 2021.6

Associations of Systolic Blood Pressure and Diastolic Blood Pressure With the Incidence of Coronary Artery Disease or Cerebrovascular Disease According to Glucose Status. International journal

Mayuko Harada Yamada, Kazuya Fujihara, Satoru Kodama, Takaaki Sato, Taeko Osawa, Yuta Yaguchi, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Hiroyasu Seida, Wataru Ogawa, Hirohito Sone

Diabetes care 44 ( 9 ) 2124 - 2131 2021.5

Accuracy of Japanese claims data in identifying diabetes-related complications. Reviewed International journal

Kazuya Fujihara, Mayuko Yamada-Harada, Yasuhiro Matsubayashi, Masaru Kitazawa, Masahiko Yamamoto, Yuta Yaguchi, Hiroyasu Seida, Satoru Kodama, Kohei Akazawa, Hirohito Sone

Pharmacoepidemiology and drug safety 30 ( 5 ) 594 - 601 2021.5

WT1-specific CD8 + cytotoxic T cells with the capacity for antigen-specific expansion accumulate in the bone marrow in MDS. Reviewed

Tatsuya Suwabe, Yasuhiko Shibasaki, Hiroyuki Sato, Suguru Tamura, Takayuki Katagiri, Hiroki Nemoto, Takuya Kasami, Takashi Kozakai, Ayako Nanba, Toshiki Kitajima, Kyoko Fuse, Takashi Ushiki, Hirohito Sone, Miwako Narita, Masayoshi Masuko

International journal of hematology 113 ( 5 ) 723 - 734 2021.5

GB療法施行中にHigh-grade B-cell lymphoma with MYC and BCL2 rearrangementsで再燃したFollicular lymphoma(Grade 3A)の2症例

水戸部正樹, 本宮奈津子, 武田ルイ, 米沢穂高, 鈴木隆晴, 諏訪部達也, 片桐隆幸, 河本啓介, 布施香子, 柴崎康彦, 増子正義, 井上佳菜子, 三好寛明, 大島孝一, 曽根博仁, 瀧澤淳

日本リンパ網内系学会会誌 61 114 - 114 2021.5

腎障害を有する高悪性度B細胞リンパ腫症例にDA-EPOCH-Rを施行した1例

水戸部正樹, 河本啓介, 鈴木隆晴, 米沢穂高, 田村秀, 諏訪部達也, 根本洋樹, 布施香子, 柴崎康彦, 増子正義, 三好寛明, 大島孝一, 曽根博仁, 瀧澤淳

臨床血液 62 ( 5 ) 532 - 532 2021.5

ルキソルチニブ・ヒドロキシウレア併用療法が奏効した慢性好中球性白血病(CNL)の1例

武田ルイ, 布施香子, 片桐隆幸, 河本啓介, 柴崎康彦, 瀧澤淳, 成田美和子, 野本信彦, 曽根博仁, 増子正義

臨床血液 62 ( 5 ) 529 - 530 2021.5

乾燥人フィブリノゲン製剤の継続輸注で着床・妊娠継続・出産をし得た先天性低フィブリノゲン血症

関義信, 牛木隆志, 増子正義, 瀧澤淳, 曽根博仁, 奥村伸生

日本血栓止血学会誌 32 ( 2 ) 214 - 214 2021.5

乾燥人フィブリノゲン製剤の継続輸注で着床・妊娠継続・出産をし得た先天性低フィブリノゲン血症

関義信, 牛木隆志, 増子正義, 瀧澤淳, 曽根博仁, 奥村伸生

日本血栓止血学会誌 32 ( 2 ) 214 - 214 2021.5

The Japanese Medical Science Federation COVID-19 Expert Opinion English Version.

Masaomi Nangaku, Takashi Kadowaki, Hiroshi Yotsuyanagi, Norio Ohmagari, Moritoki Egi, Junichi Sasaki, Tetsuya Sakamoto, Yoshinori Hasegawa, Takashi Ogura, Shigeru Chiba, Koichi Node, Ryo Suzuki, Yasuhiro Yamaguchi, Atsuko Murashima, Norihiko Ikeda, Eriko Morishita, Kenji Yuzawa, Hiroyuki Moriuchi, Satoshi Hayakawa, Daisuke Nishi, Atsushi Irisawa, Toshiaki Miyamoto, Hidetaka Suzuki, Hirohito Sone, Yuuji Fujino

JMA journal 4 ( 2 ) 148 - 162 2021.4

Language：English Publishing type：Research paper (scientific journal)

In 2020, the COVID-19 pandemic has had unprecedented impacts on various aspects of the world. Each academic society has published a guide and/or guidelines on how to cope with COVID-19 separately. As the one and only nationwide association of academic societies that represent medical science in Japan, JMSF has decided to publish the expert opinion to help patients and care providers find specifically what they want. This expert opinion is a summary of recommendations by many academic societies and will be updated when necessary. Patients that each academic society targets differ even though they suffer from the same COVID-19, and recommendations can be different in a context-dependent manner. Readers are supposed to be flexible and adjustable when they use this expert opinion.

DOI： 10.31662/jmaj.2021-0002

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Rates and risk factors for amputation in people with diabetes in Japan: a historical cohort study using a nationwide claims database. International journal

Masanori Kaneko, Kazuya Fujihara, Mayuko Yamada Harada, Taeko Osawa, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Hiroyasu Seida, Satoru Kodama, Hirohito Sone

Journal of foot and ankle research 14 ( 1 ) 29 - 29 2021.4

Physical Fitness and Dyslipidemia Among Japanese: A Cohort Study From the Niigata Wellness Study. Reviewed

Haruki Momma, Kiminori Kato, Susumu S Sawada, Yuko Gando, Ryoko Kawakami, Motohiko Miyachi, Ryoichi Nagatomi, Minoru Tashiro, Yasuhiro Matsubayashi, Satoru Kodama, Midori Iwanaga, Kazuya Fujihara, Hirohito Sone

Journal of epidemiology 31 ( 4 ) 287 - 296 2021.4

Distinct effects of chondroitin sulfate on hematopoietic cells and the stromal microenvironment in bone marrow hematopoiesis. Reviewed International journal

Takayuki Katagiri, Shun Uemura, Takashi Ushiki, Yaeko Nakajima-Takagi, Motohiko Oshima, Tadahisa Mikami, Asami Kawasaki, Hajime Ishiguro, Tomoyuki Tanaka, Hirohito Sone, Hiroshi Kitagawa, Michihiro Igarashi, Atsushi Iwama, Masayoshi Masuko

Experimental hematology 96 52 - 62 2021.4

DA-EPOCH-R therapy for high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements in a patient with renal dysfunction. Reviewed

Masaki Mitobe, Keisuke Kawamoto, Takaharu Suzuki, Tatsuya Suwabe, Yasuhiko Shibasaki, Masayoshi Masuko, Kanako Inoue, Hiroaki Miyoshi, Koichi Ohshima, Hirohito Sone, Jun Takizawa

Journal of clinical and experimental hematopathology : JCEH 61 ( 1 ) 42 - 47 2021.3

Dipeptidyl peptidase-4 inhibitor, anagliptin, alters hepatic insulin clearance in relation to the glycemic status in Japanese individuals with type 2 diabetes.

Takahiro Abe, Yasuhiro Matsubayashi, Sayaka Muragishi, Akihiro Yoshida, Hideki Suganami, Kenichi Furusawa, Kazuya Fujihara, Shiro Tanaka, Kohei Kaku, Hirohito Sone

Journal of diabetes investigation 12 ( 10 ) 1805 - 1815 2021.3

Body flexibility and incident hypertension: The Niigata wellness study. Reviewed International journal

Yuko Gando, Susumu S Sawada, Haruki Momma, Ryoko Kawakami, Motohiko Miyachi, I-Min Lee, Steven N Blair, Minoru Tashiro, Chika Horikawa, Yasuhiro Matsubayashi, Takaho Yamada, Kazuya Fujihara, Kiminori Kato, Hirohito Sone

Scandinavian journal of medicine & science in sports 31 ( 3 ) 702 - 709 2021.3

A 52-week randomized controlled trial of ipragliflozin or sitagliptin in type 2 diabetes combined with metformin: The N-ISM study. Reviewed International journal

Masaru Kitazawa, Takashi Katagiri, Hiromi Suzuki, Satoshi Matsunaga, Mayuko H Yamada, Tomoo Ikarashi, Masahiko Yamamoto, Kazuo Furukawa, Midori Iwanaga, Mariko Hatta, Kazuya Fujihara, Takaho Yamada, Shiro Tanaka, Hirohito Sone

Diabetes, obesity & metabolism 23 ( 3 ) 811 - 821 2021.3

Severity of hypertension as a predictor of initiation of dialysis among study participants with and without diabetes mellitus. Reviewed International journal

Taeko Osawa, Kazuya Fujihara, Mayuko Harada Yamada, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Midori Iwanaga, Takaho Yamada, Hiroyasu Seida, Satoru Kodama, Yoshimi Nakagawa, Hitoshi Shimano, Hirohito Sone

Journal of investigative medicine : the official publication of the American Federation for Clinical Research 69 ( 3 ) 724 - 729 2021.3

Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan

Ryosuke Tateishi, Takeshi Matsumura, Takeshi Okanoue, Toshihide Shima, Koji Uchino, Naoto Fujiwara, Takafumi Senokuchi, Kazuyoshi Kon, Takayoshi Sasako, Makiko Taniai, Takumi Kawaguchi, Hiroshi Inoue, Hirotaka Watada, Naoto Kubota, Hitoshi Shimano, Shuichi Kaneko, Etsuko Hashimoto, Sumio Watanabe, Goshi Shiota, Kohjiro Ueki, Kosuke Kashiwabara, Yutaka Matsuyama, Hideo Tanaka, Masato Kasuga, Eiichi Araki, Kazuhiko Koike, Yoshiyasu Karino, Shuhei Hige, Masatomo Sekiguchi, Koji Ogawa, Hideaki Miyoshi, Kyu Yong Cho, Masaru Baba, Atsushi Inoue, Kazuobu Aso, Mitsuyoshi Okada, Yasuhiro Takikawa, Kei Endo, Yasushi Ishigaki, Hirobumi Togashi, Michiaki Unno, Takanori Morikawa, Hideki Katagiri, Shojiro Sawada, Hiromasa Ohira, Atsushi Takahashi, Michio Shimabukuro, Akihiro Kudo, Naomi Tanaka, Junko Mitsuhashi, Toshifumi Tokai, Yasushi Matsuzaki, Tadashi Ikegami, Masato Imai, Kou Nishikawa, Sadao Takahashi, Sumiko Nagoshi, Kosuke Maezawa, Masafumi Matsuda, Tetsuhiro Chiba, Masayuki Yokoyama, Koutaro Yokote, Yoko Hidetaka, Mitsuhiko Moriyama, Hitomi Nakamura, Midori Fujishiro, Tadakazu Hisamatsu, Kaori Nishikawa, Toshihiko Nouchi, Yuki Sakurai, Harumi Daikoku, Michinori Murayama, Yoshinori Saigusa, Takashi Matsui, Ryosuke Tateishi, Hidenari Nagai, Takanori Mukozu, Takahisa Hirose, Masahiko Miyagi, Hiroaki Sato, Akira Mizuki, Masanori Miura, Yuzuru Sato, Rena Kaneko, Kumiko Hamano, Hiroko Kato, Kentaro Kikuchi, Yusuke Kajiyama, Makoto Chuma, Hiroko Ito, Hiroshi Yasuda, Nobuyuki Matsumoto, Yasushi Tanaka, Yoshio Nagai, Kento Imajo, Yasuo Terauchi, Yuzuru Ito, Shuji Terai, Hirohito Sone, Satoshi Matsunaga

Journal of Gastroenterology 56 ( 3 ) 261 - 273 2021.3

Sodium Intake and Incidence of Diabetes Complications in Elderly Patients with Type 2 Diabetes-Analysis of Data from the Japanese Elderly Diabetes Intervention Study (J-EDIT). Reviewed International journal

Chika Horikawa, Rei Aida, Shiro Tanaka, Chiemi Kamada, Sachiko Tanaka, Yukio Yoshimura, Remi Kodera, Kazuya Fujihara, Ryo Kawasaki, Tatsumi Moriya, Hidetoshi Yamashita, Hideki Ito, Hirohito Sone, Atsushi Araki

Nutrients 13 ( 2 ) 2021.2

Language：English Publishing type：Research paper (scientific journal)

This study investigates the associations between sodium intake and diabetes complications in a nationwide cohort of elderly Japanese patients with type 2 diabetes aged 65-85. Data from 912 individuals regarding their dietary intake at baseline is analyzed and assessed by the Food Frequency Questionnaire based on food groups. Primary outcomes are times to diabetic retinopathy, overt nephropathy, cardiovascular disease (CVD), and all-cause mortality during six years. We find that mean sodium intake in quartiles ranges from 2.5 g to 5.9 g/day. After adjustment for confounders, no significant associations are observed between sodium intake quartiles and incidence of diabetes complications and mortality, except for a significant trend for an increased risk of diabetic retinopathy (p = 0.039). Among patients whose vegetable intake was less than the average of 268.7 g, hazard ratios (HRs) for diabetic retinopathy in patients in the second, third, and fourth quartiles of sodium intake compared with the first quartile were 0.87 (95% CI, 0.31-2.41), 2.61 (1.00-6.83), and 3.70 (1.37-10.02), respectively. Findings indicate that high sodium intake under conditions of low vegetable intake is associated with an elevated incidence of diabetic retinopathy in elderly patients with type 2 diabetes.

DOI： 10.3390/nu13020689

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A Prospective Cohort Study of Muscular and Performance Fitness and Risk of Hearing Loss: The Niigata Wellness Study. Reviewed International journal

Ryoko Kawakami, Susumu S Sawada, Kiminori Kato, Yuko Gando, Haruki Momma, Hideaki Oike, Motohiko Miyachi, I-Min Lee, Steven N Blair, Minoru Tashiro, Chika Horikawa, Yasuhiro Matsubayashi, Takaho Yamada, Kazuya Fujihara, Hirohito Sone

The American journal of medicine 134 ( 2 ) 235 - 242 2021.2

Ability of Current Machine Learning Algorithms to Predict and Detect Hypoglycemia in Patients With Diabetes Mellitus: Meta-analysis. Reviewed International journal

Satoru Kodama, Kazuya Fujihara, Haruka Shiozaki, Chika Horikawa, Mayuko Harada Yamada, Takaaki Sato, Yuta Yaguchi, Masahiko Yamamoto, Masaru Kitazawa, Midori Iwanaga, Yasuhiro Matsubayashi, Hirohito Sone

JMIR diabetes 6 ( 1 ) e22458 2021.1

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Machine learning (ML) algorithms have been widely introduced to diabetes research including those for the identification of hypoglycemia. OBJECTIVE: The objective of this meta-analysis is to assess the current ability of ML algorithms to detect hypoglycemia (ie, alert to hypoglycemia coinciding with its symptoms) or predict hypoglycemia (ie, alert to hypoglycemia before its symptoms have occurred). METHODS: Electronic literature searches (from January 1, 1950, to September 14, 2020) were conducted using the Dialog platform that covers 96 databases of peer-reviewed literature. Included studies had to train the ML algorithm in order to build a model to detect or predict hypoglycemia and test its performance. The set of 2 × 2 data (ie, number of true positives, false positives, true negatives, and false negatives) was pooled with a hierarchical summary receiver operating characteristic model. RESULTS: A total of 33 studies (14 studies for detecting hypoglycemia and 19 studies for predicting hypoglycemia) were eligible. For detection of hypoglycemia, pooled estimates (95% CI) of sensitivity, specificity, positive likelihood ratio (PLR), and negative likelihood ratio (NLR) were 0.79 (0.75-0.83), 0.80 (0.64-0.91), 8.05 (4.79-13.51), and 0.18 (0.12-0.27), respectively. For prediction of hypoglycemia, pooled estimates (95% CI) were 0.80 (0.72-0.86) for sensitivity, 0.92 (0.87-0.96) for specificity, 10.42 (5.82-18.65) for PLR, and 0.22 (0.15-0.31) for NLR. CONCLUSIONS: Current ML algorithms have insufficient ability to detect ongoing hypoglycemia and considerate ability to predict impeding hypoglycemia in patients with diabetes mellitus using hypoglycemic drugs with regard to diagnostic tests in accordance with the Users' Guide to Medical Literature (PLR should be ≥5 and NLR should be ≤0.2 for moderate reliability). However, it should be emphasized that the clinical applicability of these ML algorithms should be evaluated according to patients' risk profiles such as for hypoglycemia and its associated complications (eg, arrhythmia, neuroglycopenia) as well as the average ability of the ML algorithms. Continued research is required to develop more accurate ML algorithms than those that currently exist and to enhance the feasibility of applying ML in clinical settings. TRIAL REGISTRATION: PROSPERO International Prospective Register of Systematic Reviews CRD42020163682; http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42020163682.

DOI： 10.2196/22458

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Machine Learning Approach to Decision Making for Insulin Initiation in Japanese Patients With Type 2 Diabetes (JDDM 58): Model Development and Validation Study. Reviewed International journal

Kazuya Fujihara, Yasuhiro Matsubayashi, Mayuko Harada Yamada, Masahiko Yamamoto, Toshihiro Iizuka, Kosuke Miyamura, Yoshinori Hasegawa, Hiroshi Maegawa, Satoru Kodama, Tatsuya Yamazaki, Hirohito Sone

JMIR medical informatics 9 ( 1 ) e22148 2021.1

Le Carbone prevents liver damage in non-alcoholic steatohepatitis-hepatocellular carcinoma mouse model via AMPKα-SIRT1 signaling pathway activation. Reviewed International journal

Mst Rejina Afrin, Somasundaram Arumugam, Vigneshwaran Pitchaimani, Vengadeshprabhu Karuppagounder, Rajarajan Amirthalingam Thandavarayan, Meilei Harima, Chowdhury Faiz Hossain, Kenji Suzuki, Hirohito Sone, Yasuhiro Matsubayashi, Kenichi Watanabe

Heliyon 7 ( 1 ) e05888 2021.1

Difference in Glycemic Control between Ipragliflozin (Ipr) and Sitagliptin (Sit) According to Changes in Energy Intake (El) and Physical Activity (PA): Post -hoc Analysis of the NISM Study

Hirohito Sone

Diabetes 2021

Easix-1yearas a Prognostic Index for Late Non-Relapse Mortality after Allogenichematopoietic Cell Transplantation

Hirohito Sone

Blood 2021

YAP/TAZ Promote Hematopoietic Regeneration Via Accelerating the Recovery of Bone Marrow Niche

Hirohito Sone

Blood 2021

Large Quantity of Alcohol Intake per Occasion was Positively Associated with Vision-Threatening Eye Diseases in Japanese Men with Type 2 Diabetes

Hirohito Sone

Diabetes 2021

The Diversity of Long-Term Persistent WT1-Specific Cytotoxic T Lymphocytes after Wilms' Tumor 1 Peptide Vaccination

Hirohito Sone

Blood 2021

Stratification of Intermediate-Risk Acute Myeloid Leukemia According to the Expression Level of WT1 mRNA at Diagnosis

Hirohito Sone

Blood 2021

Predictors of Hemoglobin (Hb) and Its Changes Focusing on Anemia and Polycythemia after Administration of the SGLT2 Inhibitor Tofogliflozin

Hirohito Sone

Diabetes 2021

Impact of Medication Adherence and Glycemic Control on the Risk of Micro/Macrovascular Diseases in Patients with DiabetesY

Hirohito Sone

Diabetes 2021

Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition. International journal

Yoshimi Nakagawa, Yunong Wang, Song-Iee Han, Kanako Okuda, Asayo Oishi, Yuka Yagishita, Kae Kumagai, Hiroshi Ohno, Yoshinori Osaki, Yuhei Mizunoe, Masaya Araki, Yuki Murayama, Hitoshi Iwasaki, Morichika Konishi, Nobuyuki Itoh, Takashi Matsuzaka, Hirohito Sone, Nobuhiro Yamada, Hitoshi Shimano

Cellular and molecular gastroenterology and hepatology 11 ( 4 ) 949 - 971 2021

Skipping breakfast, late-night eating and current smoking are associated with medication adherence in Japanese patients with diabetes. Reviewed International journal

Yuta Yaguchi, Kazuya Fujihara, Mayuko Harada Yamada, Yasuhiro Matsubayashi, Masaru Kitazawa, Taeko Osawa, Masahiko Yamamoto, Masanori Kaneko, Nauta Yamanaka, Hiroyasu Seida, Satoru Kodama, Hirohito Sone

Primary care diabetes 14 ( 6 ) 753 - 759 2020.12

Marker chromosome is a strong poor prognosis factor after allogeneic HSCT for adverse-risk AML patients. Reviewed International journal

Kyoko Fuse, Tomoyuki Tanaka, Yasuhiko Shibasaki, Tatsuo Furukawa, Miwako Narita, Hirohito Sone, Masayoshi Masuko

European journal of haematology 105 ( 5 ) 616 - 625 2020.11

Network Meta-Analysis of Drug Therapies for Lowering Uric Acid and Mortality Risk in Patients with Heart Failure. Reviewed International journal

Satoru Kodama, Kazuya Fujihara, Chika Horikawa, Mayuko Yamada, Takaaki Sato, Yuta Yaguchi, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Kenichi Watanabe, Hirohito Sone

Cardiovascular drugs and therapy 35 ( 6 ) 1217 - 1225 2020.10

A Prospective Cohort Study of Muscular and Performance Fitness and Incident Glaucoma: The Niigata Wellness Study. Reviewed International journal

Ryoko Kawakami, Yuko Gando, Kiminori Kato, Susumu S Sawada, Haruki Momma, Motohiko Miyachi, I-Min Lee, Steven N Blair, Minoru Tashiro, Chika Horikawa, Yasuhiro Matsubayashi, Takaho Yamada, Kazuya Fujihara, Hirohito Sone

Journal of physical activity & health 17 ( 11 ) 1171 - 1178 2020.10

Diabetes mellitus and risk of new-onset and recurrent heart failure: a systematic review and meta-analysis. Reviewed International journal

Satoru Kodama, Kazuya Fujihara, Chika Horikawa, Takaaki Sato, Midori Iwanaga, Takaho Yamada, Kiminori Kato, Kenichi Watanabe, Hitoshi Shimano, Tohru Izumi, Hirohito Sone

ESC heart failure 7 ( 5 ) 2146 - 2174 2020.10

Association of treatment-achieved HbA1c with incidence of coronary artery disease and severe eye disease in diabetes patients Reviewed

Hirohito Sone

Diabetes & Metabolism 46 ( 4 ) 331 - 334 2020.9

Association of treatment-achieved HbA1c with incidence of coronary artery disease and severe eye disease in diabetes patients Reviewed

M. Harada, K. Fujihara, T. Osawa, M. Yamamoto, M. Kaneko, M. Ishizawa, Y. Matsubayashi, T. Yamada, N. Yamanaka, H. Seida, S. Kodama, W. Ogawa, H. Sone

Diabetes & Metabolism 46 ( 4 ) 331 - 334 2020.9

Applications of physical performance measures to routine diabetes care for frailty prevention concept: fundamental data with grip strength, gait speed, timed chair stand speed, standing balance, and knee extension strength. Reviewed International journal

Hiroki Yokoyama, Toshihiko Shiraiwa, Mitsuyoshi Takahara, Masahiro Iwamoto, Nobuichi Kuribayashi, Takuo Nomura, Minoru Yamada, Hirohito Sone, Shin-Ichi Araki

BMJ open diabetes research & care 8 ( 1 ) 2020.9

Family Support for Medical Nutritional Therapy and Dietary Intake among Japanese with Type 2 Diabetes (JDDM 56). Reviewed International journal

Chika Horikawa, Mariko Hatta, Sakiko Yoshizawa Morikawa, Yasunaga Takeda, Mizuki Takeuchi, Kazuya Fujihara, Noriko Kato, Hiroki Yokoyama, Yoshio Kurihara, Koichi Iwasaki, Shiro Tanaka, Hiroshi Maegawa, Hirohito Sone

Nutrients 12 ( 9 ) 2020.8

Successful Treatment with Edoxaban for Disseminated Intravascular Coagulation in a Case of Aortic Dissection Complicated with Immune Thrombocytopenic Purpura. Reviewed

Shun Uemura, Hironori Kobayashi, Yoshinobu Seki, Yuki Okoshi, Hirohito Sone, Nobuhiko Nomoto

Internal medicine (Tokyo, Japan) 59 ( 16 ) 2035 - 2039 2020.8

Influence of an SGLT2 inhibitor, tofogliflozin, on the resting heart rate in relation to adipose tissue insulin resistance

Hirohito Sone

Diabetic Medicine 2020.8

ガイドラインからみた糖尿病の食事療法における課題高齢者糖尿病の食事療法

荒木厚, 大村卓也, 山岡巧弥, 田村嘉章, 曽根博仁

糖尿病 63 ( Suppl.1 ) S - 83 2020.8

1型糖尿病に対して膵腎同時移植を施行し透析およびインスリンを離脱した1例

岸裕太郎, 竹内亮, 山本正彦, 松林泰弘, 藤原和哉, 岩永みどり, 山田高穂, 曽根博仁, 三浦宏平, 小林隆, 若井俊文

糖尿病 63 ( 8 ) 558 - 558 2020.8

Brain adaptations of insulin signaling kinases, GLUT 3, p-BADser155 and nitrotyrosine expression in various hypoglycemic models of mice. Reviewed International journal

Vigneshwaran Pitchaimani, Somasundaram Arumugam, Rajarajan Amirthalingam Thandavarayan, Vengadeshprabhu Karuppagounder, Mst Rejina Afrin, Remya Sreedhar, Meilei Harima, Masahiko Nakamura, Kenichi Watanabe, Satoru Kodama, Kazuya Fujihara, Hirohito Sone

Neurochemistry international 137 104745 - 104745 2020.7

Hypertrophic pachymeningitis associated with myelodysplastic syndrome

Akane Kaihatsu, Kyoko Fuse, Hirohito Sone, Masayoshi Masuko

eJHaem 1 ( 1 ) 12 - 13 2020.7

Prevention of postprandial hypotension-related syncope by caffeine in a patient with long-standing diabetes mellitus. Reviewed

Kazuo Furukawa, Tatsuro Suzuki, Hajime Ishiguro, Hiroshi Morikawa, Keiko Sonoda, Kenichi Iijima, Masahiro Ito, Osamu Hanyu, Hirohito Sone

Endocrine journal 67 ( 6 ) 585 - 592 2020.6

Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes. Reviewed International journal

Takuya Yamaoka, Atsushi Araki, Yoshiaki Tamura, Shiro Tanaka, Kazuya Fujihara, Chika Horikawa, Rei Aida, Chiemi Kamada, Yukio Yoshimura, Tatsumi Moriya, Yasuo Ohashi, Yasuo Akanuma, Hideki Ito, Hirohito Sone

Nutrients 12 ( 6 ) 2020.6

Association of increased hepatic insulin clearance and change in serum triglycerides or β-hydroxybutyrate concentration via the sodium/glucose-cotransporter 2 inhibitor tofogliflozin. Reviewed International journal

Yasuhiro Matsubayashi, Akihiro Yoshida, Hideki Suganami, Taeko Osawa, Kazuo Furukawa, Hiroshi Suzuki, Kazuya Fujihara, Shiro Tanaka, Kohei Kaku, Hirohito Sone

Diabetes, obesity & metabolism 22 ( 6 ) 947 - 956 2020.6

Vitamin B6 intake and incidence of diabetic retinopathy in Japanese patients with type 2 diabetes: analysis of data from the Japan Diabetes Complications Study (JDCS). Reviewed International journal

Chika Horikawa, Rei Aida, Chiemi Kamada, Kazuya Fujihara, Shiro Tanaka, Sachiko Tanaka, Atsushi Araki, Yukio Yoshimura, Tatsumi Moriya, Yasuo Akanuma, Hirohito Sone

European journal of nutrition 59 ( 4 ) 1585 - 1594 2020.6

Association of Higher Baseline BNP Levels with a Greater Reduction in Plasma Volume and Increase in Beta-Hydroxybutyrate via the SGLT2 Inhibitor Tofogliflozin in Type 2 Diabetes Reviewed

Akihiro Yoshida, Yasuhiro Matsubayashi, Toshiaki Nojima, Hideki Suganami, Momoko Oe, Kazuya Fujihara, Shiro Tanaka, Kohei Kaku, Hirohito Sone

DIABETES 69 2020.6

Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice. Reviewed International journal

Takashi Matsuzaka, Motoko Kuba, Saori Koyasu, Yuta Yamamoto, Kaori Motomura, Sundaram Arulmozhiraja, Hiroshi Ohno, Rahul Sharma, Takuya Shimura, Yuka Okajima, Song-Iee Han, Yuichi Aita, Yuhei Mizunoe, Yoshinori Osaki, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Hirohito Sone, Yoshinori Takeuchi, Naoya Yahagi, Takafumi Miyamoto, Motohiro Sekiya, Yoshimi Nakagawa, Masatsugu Ema, Satoru Takahashi, Hiroaki Tokiwa, Hitoshi Shimano

Hepatology (Baltimore, Md.) 71 ( 5 ) 1609 - 1625 2020.5

Clinicopathological analysis of splenic red pulp low-grade B-cell lymphoma. Reviewed International journal

Takaharu Suzuki, Hiroaki Miyoshi, Joji Shimono, Keisuke Kawamoto, Fumiko Arakawa, Takuya Furuta, Kyohei Yamada, Eriko Yanagida, Mai Takeuchi, Masao Seto, Hirohito Sone, Jun Takizawa, Koichi Ohshima

Pathology international 70 ( 5 ) 280 - 286 2020.5

CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms. Reviewed International journal

Aoi Satoh, Song-Iee Han, Masaya Araki, Yoshimi Nakagawa, Hiroshi Ohno, Yuhei Mizunoe, Kae Kumagai, Yuki Murayama, Yoshinori Osaki, Hitoshi Iwasaki, Motohiro Sekiya, Morichika Konishi, Nobuyuki Itoh, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano

iScience 23 ( 3 ) 100930 - 100930 2020.3

Efficacy and safety of empagliflozin as add-on to insulin in Japanese patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial. Reviewed International journal

Hirohito Sone, Tatsuroh Kaneko, Kosuke Shiki, Yoshifumi Tachibana, Egon Pfarr, Jisoo Lee, Naoko Tajima

Diabetes, obesity & metabolism 22 ( 3 ) 417 - 426 2020.3

The Glasgow prognostic score divides high-risk hematopoietic cell transplantation-specific comorbidity index patients into stratified subgroups in allogeneic hematopoietic cell transplantation. Reviewed International journal

Yasuhiko Shibasaki, Tatsuya Suwabe, Takayuki Katagiri, Kyoko Fuse, Miwako Narita, Hirohito Sone, Masayoshi Masuko

Annals of hematology 99 ( 3 ) 671 - 673 2020.3

Combination of diabetes mellitus and lack of habitual physical activity is a risk factor for functional disability in Japanese. Reviewed International journal

Kazuya Fujihara, Yasuhiro Matsubayashi, Mayuko Harada Yamada, Masaru Kitazawa, Masahiko Yamamoto, Masanori Kaneko, Satoru Kodama, Takuya Yahiro, Ayumu Tsutsui, Kiminori Kato, Hirohito Sone

BMJ open diabetes research & care 8 ( 1 ) 2020.1

副甲状腺癌の全身骨転移と鑑別が困難でありBrown腫瘍が疑われた一例

山本正彦, 種村聡, 石黒創, 松林泰弘, 藤原和哉, 岩永みどり, 山田貴穂, 曽根博仁

日本内分泌学会雑誌 95 ( 3 ) 998 - 998 2020.1

Combination of Diabetes Mellitus and Lack of Habitual Physical Activity Is a Risk Factor for Functional Disability in Japanese

Hirohito Sone

Diabetes 2020

Severity of Hypertension (HT) as a Predictor of Initiation of Dialysis among Study Participants with and without Diabetes Mellitus (DM)

Hirohito Sone

Diabetes 2020

Weight and cardiometabolic risk among adolescents in Agano city, Japan: NICE EVIDENCE Study-Agano 1. Reviewed International journal

Sakiko Yoshizawa Morikawa, Kazuya Fujihara, Yasunaga Takeda, Mariko Hatta, Chika Horikawa, Masahiro Ishizawa, Masahiko Yamamoto, Tomonobu Shiraishi, Hajime Ishiguro, Takaho Yamada, Yohei Ogawa, Hirohito Sone

Asia Pacific journal of clinical nutrition 29 ( 4 ) 856 - 866 2020

Medication Adherence (MA) Is an Independent Predictor for Glycemic Control Even after Adjustment for Lifestyle Confounders in Japanese Patients with Type 2 Diabetes

Hirohito Sone

Diabetes 2020

Impact of Body Mass Index (BMI) and Waist Circumference (WC) on Coronary Artery Disease (CAD) in Japanese with and without Diabetes Mellitus (DM)

Hirohito Sone

Diabetes 2020

Predictive Ability of Incident Type 2 Diabetes Mellitus (T2DM) Using Machine Learning Algorithms: A Meta-analysis

Hirohito Sone

Diabetes 2020

Association between Plasma Metabolites in the Urea Cycle and Diabetic Kidney Disease (DKD) in a Japanese Population

Hirohito Sone

Diabetes 2020

Ability for Detecting or Predicting Hypoglycemia with the Aid of Machine Learning Techniques: A Meta-analysis

Hirohito Sone

Diabetes 2020

Blood Pressure as Predictor of Coronary Artery Disease (CAD)/Cerebrovascular Disease (CVD) According to Glucose Tolerance Status (GTS): Implications for Updated Guidelines

Hirohito Sone

Diabetes 2020

Difference between Comprehensive Physical Fitness Age and Calendar Age Is a Potent Predictor of Incident Metabolic Syndrome (MetS)

Hirohito Sone

Diabetes 2020

Low Level of and Decrease in Serum Amylase (AMY) Increases the Risk of Type 2 Diabetes Mellitus (T2DM)

Hirohito Sone

Diabetes 2020

Physical Fitness (PF), Weight Status, and Metabolic Risk in Japanese Adolescents

Hirohito Sone

Diabetes 2020

Randomized Controlled Trial of Ipragliflozin or Sitagliptin Combined with Metformin in Type 2 Diabetes: NISM Study

Hirohito Sone

Diabetes 2020

Association between Screen Time Including Smartphone Use and Obesity and Its Associated Lifestyles in School Children in Japan

Hirohito Sone

Diabetes 2020

Association of Plasma Volume with Body Weight and BNP after Long-Term Administration and Subsequent Withdrawal of the SGLT2 Inhibitor Tofogliflozin

Hirohito Sone

Diabetes 2020

Isolated Adrenocorticotropic Hormone Deficiency Presenting with Severe Hyponatremia and Rhabdomyolysis: A Case Report and Literature Review. Reviewed International journal

Takeshi Komatsu, Nobumasa Ohara, Naoko Hirota, Yuichiro Yoneoka, Takashi Tani, Keishi Terajima, Tetsutaro Ozawa, Hirohito Sone

The American journal of case reports 20 1857 - 1863 2019.12

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND Isolated adrenocorticotropic hormone deficiency (IAD) is a rare disorder characterized by central adrenal insufficiency (AI) but normal secretion of pituitary hormones other than adrenocorticotropic hormone. IAD usually presents with unspecific symptoms of AI, such as anorexia and fatigue, but some patients present with a variety of atypical manifestations. Rhabdomyolysis is a potentially life-threatening clinical syndrome caused by skeletal muscle injury with the release of muscle cell contents into the circulation. A wide variety of disorders can cause rhabdomyolysis. Herein, we report an unusual case of IAD presenting with hyponatremia and rhabdomyolysis. CASE REPORT A 67-year-old Japanese woman with a 2-month history of anorexia and fatigue was diagnosed with severe hyponatremia (serum sodium, 118 mEq/L) and rhabdomyolysis (serum creatine phosphokinase, 6968 IU/L), after 2 days of vomiting and muscle weakness. Physical and laboratory findings did not show dehydration or peripheral edema. Her rhabdomyolysis resolved with normalization of serum sodium levels during administration of sodium chloride. However, her anorexia and fatigue remained unresolved. After reducing the amount of sodium chloride administered, the patient still had hyponatremia. Detailed endocrinological examinations indicated IAD; her hyponatremia was associated with inappropriately high plasma arginine vasopressin levels. The patient received corticosteroid replacement therapy, which resolved her anorexia, fatigue, excessive arginine vasopressin, and hyponatremia. CONCLUSIONS This case highlights the importance of considering the possibility of central AI in patients with hyponatremia and excessive arginine vasopressin levels. In addition, rhabdomyolysis associated with hyponatremia can be an important manifestation of IAD.

DOI： 10.12659/AJCR.918427

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Risk of coronary artery disease according to glucose abnormality status and prior coronary artery disease in Japanese men. Reviewed International journal

Masaru Kitazawa, Kazuya Fujihara, Taeko Osawa, Masahiko Yamamoto, Mayuko Harada Yamada, Masanori Kaneko, Yasuhiro Matsubayashi, Takaho Yamada, Nauta Yamanaka, Hiroyasu Seida, Hirohito Sone

Metabolism: clinical and experimental 101 153991 - 153991 2019.12

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Although glucose abnormality status (GAS), prior coronary artery disease (CAD), and other traditional risk factors affect the incidence of subsequent CAD, their impact in the same cohort has been scantly studied. RESEARCH DESIGN AND METHODS: We analyzed data from a nationwide claims database in Japan that was accumulated during 2008-2016 involving 138,162 men aged 18-72 years. Participants were classified as having normoglycemia, borderline glycemia, or diabetes mellitus (DM) with prior CAD (CAD+) or without prior CAD (CAD-). Cox regression model identified variables related to the incidence of CAD. RESULTS: Among CAD-, management of traditional risks differed from those with and without subsequent CAD events. On the other hand, such differences were weaker in borderline glycemia and DM CAD+, and the influence of traditional risk factors on subsequent CAD was not observed. Cox regression model showed that borderline glycemia and DM confer approximately 1.2- and 2.8-fold excess risks of CAD, respectively, compared with CAD- with normoglycemia. CAD+ confers approximately a 5- to 8-fold increased risk. The impacts of DM and prior CAD additively reached a hazard ratio (HR) of 15.74 (95% confidence interval [CI]: 11.82-21.00). However, the HR in those with borderline glycemia and CAD+ was 7.20 (95% CI: 5.01-10.34), which was not different from those with normoglycemia and CAD+. CONCLUSION: Control status of traditional risk factors and impact on subsequent CAD differ among categories of glycemic status with and without prior CAD. Individualizing treatment strategies is needed in consideration of risk factors, such as GAS and CAD+.

DOI： 10.1016/j.metabol.2019.153991

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Relationship Between Number of Multiple Risk Factors and Coronary Artery Disease Risk With and Without Diabetes Mellitus. Reviewed International journal

Mayuko Yamada-Harada, Kazuya Fujihara, Taeko Osawa, Masahiko Yamamoto, Masanori Kaneko, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Nauta Yamanaka, Hiroyasu Seida, Wataru Ogawa, Hirohito Sone

The Journal of clinical endocrinology and metabolism 104 ( 11 ) 5084 - 5090 2019.11

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To determine the degree of control of multiple risk factors under real-world conditions for coronary artery disease (CAD) according to the presence or absence of diabetes mellitus (DM) and to determine whether reaching multifactorial targets for blood pressure (BP), low-density lipoprotein-cholesterol (LDL-C), HbA1c, and current smoking is associated with lower risks for CAD. METHODS: We investigated the effects on subsequent CAD of the number of controlled risk factors among BP, LDL-C, HbA1c, and current smoking in a prospective cohort study using a nationwide claims database of 220,894 individuals in Japan. Cox regression examined risks over a 4.8-year follow-up. RESULTS: The largest percentage of participants had two risk factors at target in patients with DM (39.6%) and subjects without DM (36.4%). Compared with those who had two targets achieved, the risks of CAD among those who had any one and no target achieved were two and four times greater, respectively, regardless of the presence of DM. The effect of composite control was sufficient to bring CAD risk in patients with DM below that for subjects without DM with any two targets achieved, whereas the risk of CAD in the DM group with all four risk factors uncontrolled was 9.4 times more than in the non-DM group who had achieved two targets. CONCLUSIONS: These findings show that composite control of modifiable risk factors has a large effect in patients with and without DM. The effect was sufficient to bring CAD risk in patients with DM below that in the non-DM group who had two targets achieved.

DOI： 10.1210/jc.2019-00168

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2型糖尿病発症予防のための妊娠糖尿病妊婦への非薬物的強化介入の試み

川崎麻紀, 荒田尚子, 和栗雅子, 飯村祐子, 山本周美, 川嵜有紀, 牧尉太, 玉田祥子, 青山友子, 田中茂穂, 秦健一郎, 宮越敬, 橋本貢士, 杉山隆, 安日一郎, 曽根博仁, 菊池透, 瀧本秀美, 安田和基, 小川佳宏, 大田えりか, 井上永介, 平松祐司

糖尿病と妊娠 19 ( 3 ) S - 96 2019.11

Attenuation of Weight Loss Through Improved Antilipolytic Effect in Adipose Tissue Via the SGLT2 Inhibitor Tofogliflozin Reviewed International journal

Akihiro Yoshida, Yasuhiro Matsubayashi, Toshiaki Nojima, Hideki Suganami, Takahiro Abe, Masahiro Ishizawa, Kazuya Fujihara, Shiro Tanaka, Kohei Kaku, Hirohito Sone

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 104 ( 9 ) 3647 - 3660 2019.9

Association between Helicobacter pylori infection, eradication and diabetes mellitus. Reviewed

Masayuki Kato, Akiko Toda, Ritsuko Yamamoto-Honda, Yasuji Arase, Hirohito Sone

Journal of diabetes investigation 10 ( 5 ) 1341 - 1346 2019.9

Patient-based prediction algorithm of relapse after allo-HSCT for acute Leukemia and its usefulness in the decision-making process using a machine learning approach. Reviewed International journal

Kyoko Fuse, Shun Uemura, Suguru Tamura, Tatsuya Suwabe, Takayuki Katagiri, Tomoyuki Tanaka, Takashi Ushiki, Yasuhiko Shibasaki, Naoko Sato, Toshio Yano, Takashi Kuroha, Shigeo Hashimoto, Tatsuo Furukawa, Miwako Narita, Hirohito Sone, Masayoshi Masuko

Cancer medicine 8 ( 11 ) 5058 - 5067 2019.9

Language：English Publishing type：Research paper (scientific journal)

Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for high-risk acute leukemia (AL), some patients still relapse. Since patients simultaneously have many prognostic factors, difficulties are associated with the construction of a patient-based prediction algorithm of relapse. The alternating decision tree (ADTree) is a successful classification method that combines decision trees with the predictive accuracy of boosting. It is a component of machine learning (ML) and has the capacity to simultaneously analyze multiple factors. Using ADTree, we attempted to construct a prediction model of leukemia relapse within 1 year of transplantation. With the model of training data (n = 148), prediction accuracy, the AUC of ROC, and the κ-statistic value were 78.4%, 0.746, and 0.508, respectively. The false positive rate (FPR) of the relapse prediction was as low as 0.134. In an evaluation of the model with validation data (n = 69), prediction accuracy, AUC, and FPR of the relapse prediction were similar at 71.0%, 0.667, and 0.216, respectively. These results suggest that the model is generalized and highly accurate. Furthermore, the output of ADTree may visualize the branch point of treatment. For example, the selection of donor types resulted in different relapse predictions. Therefore, clinicians may change treatment options by referring to the model, thereby improving outcomes. The present results indicate that ML, such as ADTree, will contribute to the decision-making process in the diversified allo-HSCT field and be useful for preventing the relapse of leukemia.

DOI： 10.1002/cam4.2401

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大血管障害耐糖能状態及び心血管疾患既往の有無で層別化した、心血管疾患発症リスクの検討 Reviewed

北澤勝, 藤原和哉, 山田万祐子, 大澤妙子, 山本正彦, 矢口雄大, 金子正儀, 松林泰弘, 山田貴穂, 清田浩康, 曽根博仁

糖尿病合併症 33 ( Suppl.1 ) 242 - 242 2019.9

眼科処置を要する重症糖尿病性眼疾患発生リスクと血液学的因子の関係についての検討 Reviewed

山本正彦, 藤原和哉, 大澤妙子, 山田万祐子, 石澤正博, 石黒創, 鈴木浩史, 松林泰弘, 児玉暁, 長谷部日, 曽根博仁

糖尿病合併症 33 ( Suppl.1 ) 263 - 263 2019.9

大血管障害糖尿病、非糖尿患者における血糖・血圧・脂質・喫煙の管理目標の達成状況と冠動脈疾患発症の関連 Reviewed

山田万祐子, 藤原和哉, 大澤妙子, 山本正彦, 石澤正博, 金子正儀, 松林泰弘, 清田浩康, 山田貴穂, 曽根博仁

糖尿病合併症 33 ( Suppl.1 ) 241 - 241 2019.9

青少年期の体格と代謝指標の関連 Reviewed

森川咲子, 治田麻理子, 平澤玲子, 谷内洋子, 堀川千嘉, 曽根博仁

New Diet Therapy 35 ( 2 ) 151 - 151 2019.9

Effect of family-oriented diabetes programs on glycemic control: A meta-analysis. Reviewed International journal

Satoru Kodama, Sakiko Morikawa, Chika Horikawa, Dai Ishii, Kazuya Fujihara, Masahiko Yamamoto, Taeko Osawa, Masaru Kitazawa, Takaho Yamada, Kiminori Kato, Shiro Tanaka, Hirohito Sone

Family practice 36 ( 4 ) 387 - 394 2019.7

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Efficacy of programs for patients with diabetes mellitus (DM) that have promoted family members to help with patients' self-care activities has been largely inconsistent. This meta-analysis aims to assess the effect of family-oriented diabetes programs for glycemic control (GC). METHODS: Electronic literature searches were conducted for clinical trials with a parallel design wherein there were two groups according to whether family members were included (intervention group) or not included (control group) and changes in glycohemoglobin A1C (A1C) were assessed as a study outcome. Each effect size (i.e. difference in A1C change between the intervention and control group) was pooled with a random-effects model. RESULTS: There were 31 eligible trials consisting of 1466 and 1415 patients in the intervention and control groups, respectively. Pooled A1C change [95% confidence interval (CI)] was -0.45% (-0.64% to -0.26%). Limiting analyses to 21 trials targeted at patients with type 1 DM or 9 trials targeted at patients with type 2 DM, the pooled A1C changes (95% CI) were -0.35% (-0.55% to -0.14%) and -0.71% (-1.09% to -0.33%), respectively. CONCLUSION: This meta-analysis suggests that focusing on the family as well as the individual patient in self-management diabetes programs to improve the performance of self-care activities of patients with DM is effective in terms of proper GC.

DOI： 10.1093/fampra/cmy112

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Blake's pouch cystに伴う水頭症の治療により若年性認知症の改善を認めた糖尿病の1例 Reviewed

種村聡, 山本正彦, 石黒創, 岩永みどり, 松林泰弘, 山田貴穂, 藤原和哉, 渡邊賢一, 曽根博仁

糖尿病 62 ( 7 ) 441 - 441 2019.7

Overt Proteinuria, Moderately Reduced eGFR and Their Combination Are Predictive of Severe Diabetic Retinopathy or Diabetic Macular Edema in Diabetes. Reviewed International journal

Masahiko Yamamoto, Kazuya Fujihara, Masahiro Ishizawa, Taeko Osawa, Masanori Kaneko, Hajime Ishiguro, Yasuhiro Matsubayashi, Hiroyasu Seida, Nauta Yamanaka, Shiro Tanaka, Satoru Kodama, Hiruma Hasebe, Hirohito Sone

Investigative ophthalmology & visual science 60 ( 7 ) 2685 - 2689 2019.6

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

Purpose: Since the combined effects of proteinuria and a moderately decreased eGFR on incident severe eye complications in patients with diabetes are still largely unknown, these associations were determined in a large historical cohort of Japanese patients with diabetes mellitus. Methods: We evaluated the effects of overt proteinuria (OP) (dipstick 1+ and over) and/or moderately reduced estimated glomerular filtration rate (eGFR) (MG) (baseline eGFR 30.0-54.9 mL/min/1.73 m2) on the incidence of treatment-required diabetic eye diseases (TRDED). We divided 7709 patients into four groups according to the presence or absence of OP and MG: no OP without MG (NP[MG-]), OP without MG (OP[MG-]), no OP with MG (NP[MG+]), and OP with MG (OP[MG+]). Multivariate Cox analyses were performed to calculate hazard ratios (HRs) with 95% confidence intervals for combinations of the presence and/or absence of OP and MG on the risk of developing TRDED. Results: During the median follow-up period of 5.6 years, 168 patients developed TRDED. HRs for OP and MG for incident TRDED were 1.91 (95% confidence interval, 1.27-2.87) and 1.90 (1.11-3.23), respectively. HRs for incident TRDED were 1.73 (1.11-2.69) and 5.57 (2.40-12.94) for OP(MG-) and OP(MG+), respectively, in comparison with NP(MG-). Conclusions: In Japanese patients with diabetes, OP and MG were separately as well as additionally associated with higher risks of TRDED. Results indicate the necessity of the simultaneous assessment of proteinuria and eGFR for appropriate evaluation of risks of severe eye complications in patients with diabetes.

DOI： 10.1167/iovs.19-26749

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Combined Effects of Energy Intake and Physical Activity on Obesity in Japanese Patients with Type 2 Diabetes (JDDM 50): A Cross-Sectional Study. Reviewed International journal

Mariko Hatta, Kazuya Fujihara, Sakiko Yoshizawa Morikawa, Yasutake Takeda, Dai Ishii, Chika Horikawa, Mitsutoshi Kato, Hiroki Yokoyama, Yoshio Kurihara, Koichi Iwasaki, Kazuhiro Miyazawa, Katsuya Yamazaki, Shiro Tanaka, Hiroshi Maegawa, Hirohito Sone

Diabetes therapy : research, treatment and education of diabetes and related disorders 10 ( 3 ) 1133 - 1138 2019.6

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: The combined effects of energy intake (EI) and physical activity (PA) on obesity have been poorly investigated. We have investigated the combined effects of EI and PA quantitatively in Japanese men and women with type 2 diabetes. METHODS: Data on 1395 patients with type 2 diabetes who attended 25 diabetes clinics located throughout Japan, obtained by questionnaire, were analyzed. A logistic regression model was used to calculate the odds ratio for obesity. RESULTS: Multi-adjusted odds ratios for the top versus the bottom tertile of EI and the bottom versus the top tertile of PA were 1.39 (95% confidence interval [CI] 1.02-1.89) and 1.64 (95% CI 1.22-2.22), respectively. The combination of EI (kcal/day) ≥ 1967 and PA (metabolic equivalents [METs] h/week) ≤ 9.9 for men and of EI ≥ 1815 and PA ≤ 8.3 for women were significantly associated with obesity. CONCLUSIONS: The existence of "allowable maximum EI" and "required minimum PA" that is significantly associated with "not being obese" is implied, suggesting the need for lifestyle education for Japanese patients with type 2 diabetes.

DOI： 10.1007/s13300-019-0610-x

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Impact of Prior Coronary Artery Disease (CAD)/Cerebrovascular Disease (CVD) and Diabetes Mellitus (DM) on Incident CAD/CVD in Japanese Reviewed

Hirohito Sone

Diabetes 68 ( Supplement 1 ) 450 - P 2019.6

Enhanced Response in Serum Ketone Level in Men Compared with Women by Administration of SGLT2 Inhibitor Reviewed

Akihiro Yoshida, Yasuhiro Matsubayashi, Toshiaki Nojima, Hideki Suganami, Kohei Kaku, Hirohito Sone

DIABETES 68 2019.6

Pulse Pressure is a Stronger Predictor Than Systolic Blood Pressure for Severe Eye Diseases in Diabetes Mellitus. Reviewed International journal

Journal of the American Heart Association 8 ( 8 ) e010627 2019.4

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

Background Evidence of the role of systolic blood pressure ( SBP ) in development of severe diabetic retinopathy is not strong, although the adverse effect of low diastolic blood pressure has been a partial explanation. We assessed the predictive ability of incident severe diabetic retinopathy between pulse pressure ( PP ) which considers both SBP and diastolic blood pressure, compared with SBP . Methods and Results Eligible patients (12 242, 83% men) aged 19 to 72 years from a nationwide claims database were analyzed for a median observational 4.8-year period. Severe diabetic retinopathy was defined as vision-threatening treatment-required diabetic eye diseases. Multivariate Cox regression analysis revealed that hazard ratios (95% CI ) of treatment-required diabetic eye diseases for 1 increment of standard deviation and the top tertile compared with the bottom tertile were 1.39 (1.21-1.60) and 1.72 (1.17-2.51), respectively, for PP and 1.22 (1.05-1.41) and 1.43 (0.97-2.11), respectively, for SBP adjusted for age, sex, body mass index, hemoglobin A1c, fasting plasma glucose, lipids, and smoking status. In a model with SBP and PP simultaneously as covariates, the hazard ratios of only PP (hazard ratios [95% CI ], 1.57 [1.26-1.96]) but not SBP (0.85 [0.68-1.07]) were statistically significant. Delong test revealed a significant difference in the area under the receiver operating characteristic curve between PP and SBP (area under the receiver operating characteristic curve [95% CI ], 0.58 [0.54-0.63] versus 0.54 [0.50-0.59]; P=0.03). The strongest predictor remained as hemoglobin A1c (area under the receiver operating characteristic curve [95% CI ], 0.80 [0.77-0.84]). Conclusions After excluding the significant impact of glycemic control, PP in comparison with SBP is a better predictor of severe diabetic retinopathy, suggesting a role of diastolic blood pressure and arterial stiffness in pathology.

DOI： 10.1161/JAHA.118.010627

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Physical Fitness Tests and Type 2 Diabetes Among Japanese: A Longitudinal Study From the Niigata Wellness Study. Reviewed

Haruki Momma, Susumu S Sawada, Kiminori Kato, Yuko Gando, Ryoko Kawakami, Motohiko Miyachi, Cong Huang, Ryoichi Nagatomi, Minoru Tashiro, Masahiro Ishizawa, Satoru Kodama, Midori Iwanaga, Kazuya Fujihara, Hirohito Sone

Journal of epidemiology 29 ( 4 ) 139 - 146 2019.4

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Simple physical fitness test can be a useful potential predictor of type 2 diabetes (T2DM). We examined the association between performances on simple physical fitness tests and the incidence of T2DM. METHODS: This longitudinal study was conducted in 21,802 nondiabetic Japanese (6,649 women) aged 20 to 92 years, who underwent all physical fitness tests at baseline (April 2001 to March 2002). From April 2001 to March 2008, physical fitness tests, including grip strength, vertical jump, single-leg balance with eyes closed, forward bending, whole-body reaction time, and supine legs-up, were performed every year. Participants had physical fitness tests at least two times during the period. T2DM was also annually determined based on fasting blood glucose, glycated hemoglobin, and self-reported diabetes during the period. Discrete-time logit models were used to examine the influence of the serial level of each physical fitness test on the incidence of T2DM. RESULTS: During the entire study period, 972 participants developed diabetes. Lower relative grip strength (grip strength/body weight) and single-leg balance performance were associated with a higher incidence of T2DM. For relative grip strength, as compared with the fourth quartile group, the odds ratios for other groups ranged from 1.16 to 1.56 (P for trend < 0.001). For single-leg balance, the odds ratios ranged from 1.03 to 1.49 (P for trend < 0.001). CONCLUSION: The performance of a simple single-leg balance test as well as that of a grip strength test were negatively associated with the risk of T2DM among Japanese.

DOI： 10.2188/jea.JE20170280

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Safety and effective salvage regimen comprising a novel combination of brentuximab vedotin, L-asparaginase, and dexamethasone for refractory anaplastic large cell lymphoma, anaplastic lymphoma kinase negative. Reviewed International journal

Keisuke Kawamoto, Takaharu Suzuki, Takuya Kasami, Maiko Kiryu, Hirohito Sone, Hiroaki Miyoshi, Koichi Ohshima, Jun Takizawa

Hematological oncology 37 ( 2 ) 212 - 214 2019.4

糖尿病の有無別にみた血糖・血圧・脂質・喫煙の各管理目標達成状況が冠動脈疾患発症に及ぼす影響 Reviewed

原田万祐子, 藤原和哉, 大澤妙子, 石澤正博, 山本正彦, 金子正儀, 松林泰弘, 清田浩康, 山田貴穂, 小川渉, 曽根博仁

糖尿病 62 ( Suppl.1 ) S - 285 2019.4

糖尿病の有無別にみた高血圧が透析導入に及ぼす影響の検討 Reviewed

大澤妙子, 藤原和哉, 山本正彦, 原田万祐子, 北澤勝, 金子正儀, 石黒創, 石澤正博, 松林泰弘, 清田浩康, 山中菜詩, 山田貴穂, 曽根博仁

糖尿病 62 ( Suppl.1 ) S - 219 2019.4

糖尿病(DM)・冠動脈疾患(CAD)・脳血管疾患(CVD)の既往及び組み合わせがその後のリスクへ及ぼす影響の検討 Reviewed

藤原和哉, 松林泰弘, 原田万祐子, 大澤妙子, 金子正儀, 山本正彦, 山田高穂, 清田浩康, 加藤公則, 曽根博仁

糖尿病 62 ( Suppl.1 ) S - 254 2019.4

医療ビッグデータを用いた糖尿病患者の下肢切断に関するリスク因子の検討 Reviewed

金子正儀, 藤原和哉, 原田万祐子, 山本正彦, 松林泰弘, 北澤勝, 石井大, 清田浩康, 曽根博仁

糖尿病 62 ( Suppl.1 ) S - 195 2019.4

2型糖尿病患者における食事エネルギー密度と食事パターンとの関連 Reviewed

武田安永, 藤原和哉, 治田麻理子, 森川咲子, 堀川千嘉, 石井大, 根立梨奈, 加藤光敏, 横山宏樹, 栗原義夫, 宮澤一裕, 岩崎晧一, 川井紘一, 朝長修, 屋宜宣治, 前川聡, 曽根博仁

糖尿病 62 ( Suppl.1 ) S - 116 2019.4

耐糖能状態と心血管疾患既往の有無別に見たその後の心血管疾患発症リスク Reviewed

北澤勝, 藤原和哉, 原田万祐子, 大澤妙子, 山本正彦, 矢口雄大, 金子正儀, 松林泰弘, 山田貴穂, 清田浩康, 曽根博仁

糖尿病 62 ( Suppl.1 ) S - 190 2019.4

Higher pulse pressure predicts initiation of dialysis in Japanese patients with diabetes. Reviewed International journal

Taeko Osawa, Kazuya Fujihara, Mayuko Harada, Masahiko Yamamoto, Masahiro Ishizawa, Hiroshi Suzuki, Hajime Ishiguro, Yasuhiro Matsubayashi, Hiroyasu Seida, Nauta Yamanaka, Shiro Tanaka, Hitoshi Shimano, Satoru Kodama, Hirohito Sone

Diabetes/metabolism research and reviews 35 ( 3 ) e3120 2019.3

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

AIMS: To determine incidence and predictors of starting dialysis in patients with diabetes emphasizing blood pressure variables. METHODS: A nationwide database with claim data on 18 935 people (15 789 men and 3146 women) with diabetes mellitus aged 19 to 72 years in Japan was used to elucidate predictors for starting dialysis. Initiation of dialysis was determined from claims using ICD-10 codes and medical procedures. Using multivariate Cox modelling, interactions between glycaemic and blood pressure values were determined. RESULTS: During a median follow-up of 5.3 years, incidence of dialysis was 0.81 per 1000 person-years. Multivariate analysis of a model involving systolic and diastolic blood pressure (SBP and DBP) simultaneously as covariates showed that hazard ratios (HRs) for starting dialysis for each 1-SD elevation in SBP and DBP were 2.05 (95% confidence interval 1.58-2.64) and 0.66 (0.50-0.88), respectively, implying that pulse pressure (PP) was a promising predictor. For confirmation, a model involving SBP and PP simultaneously as covariates demonstrated that HRs for each 1-SD elevation in SBP and PP were 1.09 (0.81-1.48) and 1.54 (1.14-2.08), respectively, with PP the more potent predictor. Compared with HbA1c <8% and PP <60 mmHg, the HR for those with HbA1c ≥8% and PP ≥60 mmHg was 6.32 (3.42-11.7). CONCLUSIONS: In our historical cohort analysis, SBP and PP were independent predictors for starting dialysis. PP was the more potent, suggesting the contribution of increased arterial stiffness to the incidence of dialysis. Future studies are needed to conclude the independent influence of PP and HbA1c on dialysis considering other risk factors.

DOI： 10.1002/dmrr.3120

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Gemcitabine, Dexamethasone, and Cisplatin Regimen as an Effective Salvage Therapy for High-grade B-cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements. Reviewed

Masaki Mitobe, Keisuke Kawamoto, Takaharu Suzuki, Maiko Kiryu, Suguru Tamura, Ayako Nanba, Tatsuya Suwabe, Tomoyuki Tanaka, Kyoko Fuse, Yasuhiko Shibasaki, Masayoshi Masuko, Hiroaki Miyoshi, Koichi Ohshima, Hirohito Sone, Jun Takizawa

Internal medicine (Tokyo, Japan) 58 ( 4 ) 575 - 580 2019.2

Language：English Publishing type：Research paper (scientific journal)

A 61-year-old woman exhibited right inguinal lymphadenopathy and right lower limb edema approximately 1 month prior to hospitalization. She was diagnosed with high grade B-cell lymphoma, and a lymph node biopsy and fluorescence in situ hybridization indicated MYC, BCL2, and BCL6 rearrangements (triple-hit lymphoma). She had progressive disease that was CD20-negative after two courses of rituximab, cyclophosphamide, doxorubicin, vincristine, methotrexate/ifosfamide, etoposide, high-dose cytarabine (R-CODOX-M/IVAC) therapy. Subsequent etoposide, prednisolone, vincristine, cyclophosphamide, doxorubicin (EPOCH) therapy was not effective. However, after two cycles of gemcitabine, dexamethasone, and cisplatin (GDP) therapy, she achieved a complete response and was able to undergo autologous peripheral blood stem cell transplantation. GDP therapy may be effective as salvage therapy for chemotherapy-resistant triple-hit lymphoma.

DOI： 10.2169/internalmedicine.1686-18

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Meat intake and incidence of cardiovascular disease in Japanese patients with type 2 diabetes: analysis of the Japan Diabetes Complications Study (JDCS). Reviewed International journal

Chika Horikawa, Chiemi Kamada, Shiro Tanaka, Sachiko Tanaka, Atsushi Araki, Hideki Ito, Satoshi Matsunaga, Kazuya Fujihara, Yukio Yoshimura, Yasuo Ohashi, Yasuo Akanuma, Hirohito Sone

European journal of nutrition 58 ( 1 ) 281 - 290 2019.2

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Excessive meat intake has been researched as a major cause of cardiovascular disease (CVD) among healthy adults, but data on this topic in Asian patients with diabetes are sparse. The quantity and variety of available meats vary widely between Asian and Western countries. As part of a nationwide cohort study we investigated the relationship between meat intake and incidence of CVD in Japanese patients with type 2 diabetes aged 40-70 years with HbA1c ≥ 6.5%. METHODS: Analyzed were 1353 responders to a baseline dietary survey assessed by the Food Frequency Questionnaire based on food groups. Primary outcome was the 8-year risk of a CVD event, including coronary heart disease (CHD) and stroke. Cox regression analyses estimated hazard ratios (HRs) for dietary intake adjusted for age, gender, body mass index, HbA1c, smoking, energy intake, and other confounders. RESULTS: Mean meat intake in quartiles ranged from 9.9 to 97.7 g/day. After adjusting for confounders, HRs of CHD in the 2nd, 3rd, and 4th quartiles for meat intake compared with the 1st quartile were 2.84 (95% confidence interval 1.29-6.24, p = 0.01), 3.02 (1.36-6.70, p < 0.01), and 2.99 (1.35-6.65, p = 0.01), respectively. In two groups according to meat intake, patients consuming ≥ 20 g/day of meat had a 2.94-fold higher risk of CHD than those consuming < 20 g/day (p < 0.01). There was no significant association of stroke with meat intake. CONCLUSIONS: An elevated incidence of CHD in Japanese patients with type 2 diabetes was associated with high meat intake.

DOI： 10.1007/s00394-017-1592-y

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Baseline Lactate Level Is a Useful Predictor for Weight Loss after Long-Term SGLT2 Inhibitor Treatment

Hirohito Sone

Diabetes 2019

Associations of Blood Pressure (BP) with Incidence of Coronary Artery Disease (CAD)/Cerebrovascular Disease (CVD) According to Glucose Tolerance Status (GTS)

Hirohito Sone

Diabetes 2019

Impact of Prior Cerebrovascular Disease (CVD) and Glucose Tolerance Status on Incident CVD in Japanese

Hirohito Sone

Diabetes 2019

Weight Status and Cardiometabolic Risk Factors among Adolescents in Japan

Hirohito Sone

Diabetes 2019

Predictors and Their Impact on Coronary Artery Disease (CAD) According to Glucose Tolerance Status (GTS) and Prior CAD: Historical Cohort Study in Japan

Hirohito Sone

Diabetes 2019

Poor Adherence to Medication and HbA1c Level Predict Risk of Amputation in Patients with Diabetes Mellitus-Historical Cohort Study Using a Nationwide Claims Database

Hirohito Sone

Diabetes 2019

Depletion of Pre-Transplant Skeletal Muscle Is a Significant Poor Prognostic Factor in Allogeneic Hematopoietic Cell Transplantation

Hirohito Sone

Blood 2019

Adipose Tissue Insulin Resistance Predicts Ketosis via an SGLT2 Inhibitor

Hirohito Sone

Diabetes 2019

Serum Amylase (AMY) Level and Its Chronological Change as a Predictor of Incident Type 2 Diabetes Mellitus (T2DM)

Hirohito Sone

Diabetes 2019

Anaplastic large cell lymphoma, with 1,25(OH) 2 D 3 -mediated hypercalcemia: A case report. Reviewed

Masaki Mitobe, Keisuke Kawamoto, Takaharu Suzuki, Maiko Kiryu, Ayako Nanba, Tatsuya Suwabe, Tomoyuki Tanaka, Kyoko Fuse, Yasuhiko Shibasaki, Masayoshi Masuko, Hiroaki Miyoshi, Koichi Ohshima, Hirohito Sone, Jun Takizawa

Journal of clinical and experimental hematopathology : JCEH 59 ( 1 ) 22 - 28 2019

Physical Fitness Tests and Type 2 Diabetes Among Japanese: A Longitudinal Study From the Niigata Wellness Study. Reviewed

Momma H, Sawada SS, Kato K, Gando Y, Kawakami R, Miyachi M, Huang C, Nagatomi R, Tashiro M, Ishizawa M, Kodama S, Iwanaga M, Fujihara K, Sone H

J Epidemiol 29 ( 4 ) 139 - 146 2019

Glutamic Acid Decarboxylase Autoantibody-negative Slowly Progressive Type 1 Diabetes Mellitus: A Case Report and Literature Review. Reviewed

Michi Kobayashi, Nobumasa Ohara, Yohei Ikeda, Ouki Nagano, Toshinori Takada, Makoto Kodama, Hirohito Sone

Internal medicine (Tokyo, Japan) 57 ( 24 ) 3581 - 3587 2018.12

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

A 59-year-old non-obese Japanese woman developed diabetes mellitus with a negative glutamic acid decarboxylase autoantibody (GADA) test result. Her hyperglycemia was initially well controlled by oral hypoglycemic agents; however, despite continued treatment the hyperglycemia gradually worsened. As she had endogenous insulin deficiency and tested positive for insulin autoantibody (IAA), insulin therapy was initiated. Few studies have investigated GADA-negative patients with slowly progressive type 1 diabetes mellitus (SPT1D). Our IAA-positive SPT1D patient progressed from the clinical onset of diabetes mellitus to starting insulin therapy relatively quickly (1.5 years), similarly to other previously reported non-obese patients with GADA-positive SPT1D.

DOI： 10.2169/internalmedicine.1008-18

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Cladribine treatment for Erdheim-Chester disease involving the central nervous system and concomitant polycythemia vera: A case report. Reviewed

Suguru Tamura, Keisuke Kawamoto, Hiroaki Miyoshi, Takaharu Suzuki, Takayuki Katagiri, Takuya Kasami, Hiroki Nemoto, Shukuko Miyakoshi, Hironori Kobayashi, Yasuhiko Shibasaki, Masayoshi Masuko, Kengo Takeuchi, Koichi Ohshima, Hirohito Sone, Jun Takizawa

Journal of clinical and experimental hematopathology : JCEH 58 ( 4 ) 161 - 165 2018.12

Language：English Publishing type：Research paper (scientific journal)

Erdheim-Chester disease (ECD), a rare form of non-Langerhans cell histiocytosis, is characterized by the infiltration of foamy CD68+ and CD1a- histiocytes into multiple organ systems. Central nervous system (CNS) involvement has recently been reported to be a poor prognostic factor when treating ECD with interferon alpha. We report the case of a 66-year-old Japanese patient with ECD involving the CNS who harbored the BRAF V600E mutation and also concomitantly developed polycythemia vera with the JAK2 V617F mutation. We confirmed 2-chlorodeoxyadenosine (cladribine) therapy to be effective for the patient in this case.

DOI： 10.3960/jslrt.18015

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当科で経験した下垂体茎断裂症候群の1例 Reviewed

佐藤隆明, 金子正儀, 福武嶺一, 安楽匠, 種村聡, 今西明, 矢口雄大, 山本正彦, 鈴木達郎, 石黒創, 松林泰弘, 山田貴穂, 岩永みどり, 藤原和哉, 曽根博仁

新潟医学会雑誌 132 ( 11-12 ) 399 - 399 2018.12

Relationship between intake of fruit separately from vegetables and triglycerides - A meta-analysis. Reviewed International journal

Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Dai Ishii, Mariko Hatta, Yasunaga Takeda, Masaru Kitazawa, Yasuhiro Matsubayashi, Hitoshi Shimano, Kiminori Kato, Shiro Tanaka, Hirohito Sone

Clinical nutrition ESPEN 27 53 - 58 2018.10

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND & AIMS: High intake of fruit and vegetables is recommended for cardiovascular health. However, there have been persistent beliefs that fruits having high concentrations of fructose elevate the level of triglycerides (TG) in blood unlike vegetables. This meta-analysis aims to clarify the relationship between fruit intake and TG or hypertriglyceridemia. METHODS: Electronic literature searches were conducted for observational studies that investigated the relationship between fruit intake and hypertriglyceridemia or intervention studies that investigated the effect of increasing fruit intake on TG. Each effect size was pooled with an inverse-variance method. RESULTS: Five cross-sectional studies and only 2 intervention studies were eligible. The pooled odds ratio (OR) (95% confidence interval (CI)) of the 5 cross-sectional studies for the highest vs. the lowest fruit intake category was 0.79 (0.72-0.87). In these studies, the pooled OR for the highest vs. the lowest vegetable intake category was not significant (OR = 0.92; 95% CI, (0.82-1.03)). A linear dose-response association was observed between increases in fruit intake and ORs for hypertriglyceridemia; the OR (95% CI) for an incrementally increased intake of fruit by 1 serving/day was 0.91 (0.84-0.98). CONCLUSION: This meta-analysis suggests that high intake of fruit but not vegetables is inversely associated with hypertriglyceridemia. More trials are needed to clarify whether increasing fruit intake would reduce the level of TG and/or incident hypertriglyceridemia.

DOI： 10.1016/j.clnesp.2018.07.001

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Network meta‐analysis of the relative efficacy of bariatric surgeries for diabetes remission Reviewed

Kodama S, Fujihara K, Horikawa C, Harada M, Ishiguro H, Kaneko M, Furukawa K, Matsubayashi Y, Matsunaga S, Shimano H, Tanaka S, Kato K, Sone H

Obesity reviews 19 ( 12 ) 1621 - 1629 2018.9

糖尿病重症視力障害発症とHbA1cの関連性についての検討 Reviewed

山本正彦, 藤原和哉, 五十嵐理沙, 石澤正博, 松林泰弘, 松永佐澄志, 伊藤知恵, 錦野理絵, 山中菜詩, 児玉暁, 曽根博仁

日本糖尿病眼学会誌 22 134 - 134 2018.9

Refinement of the Glasgow Prognostic Score as a pre-transplant risk assessment for allogeneic hematopoietic cell transplantation. Reviewed

Yasuhiko Shibasaki, Tatsuya Suwabe, Takayuki Katagiri, Tomoyuki Tanaka, Takashi Ushiki, Kyoko Fuse, Naoko Sato, Toshio Yano, Takashi Kuroha, Shigeo Hashimoto, Miwako Narita, Tatsuo Furukawa, Hirohito Sone, Masayoshi Masuko

International journal of hematology 108 ( 3 ) 282 - 289 2018.9

ステロイド糖尿病を合併し歯性感染から上顎の骨髄炎を発症した2型糖尿病の1例 Reviewed

棚橋怜生, 山本正彦, 松林泰弘, 松永佐澄志, 山田貴穂, 岩永みどり, 藤原和哉, 羽入修, 曽根博仁

糖尿病 61 ( 9 ) 644 - 644 2018.9

糖尿病重症視力障害発症とHbA1cの関連性についての検討

山本正彦, 藤原和哉, 五十嵐理沙, 石澤正博, 松林泰弘, 松永佐澄志, 伊藤知恵, 錦野理絵, 山中菜詩, 児玉暁, 曽根博仁

日本糖尿病眼学会誌 22 134 - 134 2018.9

Expression of programmed death ligand 1 is associated with poor prognosis in myeloid sarcoma patients. Reviewed International journal

Keisuke Kawamoto, Hiroaki Miyoshi, Takaharu Suzuki, Junichi Kiyasu, Shintaro Yokoyama, Yuya Sasaki, Hirohito Sone, Masao Seto, Jun Takizawa, Koichi Ohshima

Hematological oncology 36 ( 3 ) 591 - 599 2018.8

Language：English Publishing type：Research paper (scientific journal)

Myeloid sarcoma (MS) is a rare condition and is an extramedullary tumour of immature myeloid cells. It is now known that the programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway suppresses the host antitumor responses and that these products are expressed on both tumour cells and tumour-infiltrating cells in various malignancies. However, little is known about the significance of PD-1/PD-L1 expression on tumour cells and tumour microenvironmental cells in MS. To investigate the clinicopathological significance of PD-1/PD-L1 expression in MS, we analyzed 98 patients by immunohistochemistry. Of these, 10.2% of cases had neoplastic tumour cells positive for PD-L1 (nPD-L1+ ). However, the rate of nPD-L1+ was <5% (range: 0.27 to 2.97%). On the other hand, PD-L1 expression on 1 or more of stromal cells in the tumour microenvironment (miPD-L1+ ) was observed in 37.8% of cases. Because all nPD-L1+ cases expressed PD-1 on less than 5% of tumour cells, we compared the miPD-L1+ and miPD-L1- groups. There was a correlation between miPD-L1+ status and the number of PD-1-expressing tumour -infiltrating lymphocytes (PD-1+ TILs; P = .0229). miPD-L1+ was found to be associated with poorer overall survival and progression-free survival (P = .00392, P = .00261, respectively). Multivariate analysis also confirmed miPD-L1+ to be an independent poor prognostic factor. In conclusion, our study indicated that the immunotherapy blocking the PD-1/PD-L1 pathway may improve the clinical outcome of MS.

DOI： 10.1002/hon.2506

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Heterogeneity of intrahepatic iron deposition in transfusion-dependent iron overload patients with hematological malignancies. Reviewed International journal

Hironori Kobayashi, Norihiko Yoshimura, Shun Uemura, Takayuki Katagiri, Tomoyuki Tanaka, Takashi Ushiki, Kyoko Fuse, Yasuhiko Shibasaki, Miwako Narita, Hirohito Sone, Masayoshi Masuko

Leukemia research 70 41 - 44 2018.7

Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance. Reviewed International journal

Hiroshi Ohno, Takashi Matsuzaka, Nie Tang, Rahul Sharma, Kaori Motomura, Takuya Shimura, Aoi Satoh, Song-Iee Han, Yoshinori Takeuchi, Yuichi Aita, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Motohiro Sekiya, Yoshimi Nakagawa, Hirohito Sone, Naoya Yahagi, Nobuhiro Yamada, Yoshikazu Higami, Hitoshi Shimano

Endocrinology 159 ( 6 ) 2308 - 2323 2018.6

Relationships among cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors in Japanese adolescents: Niigata screening for and preventing the development of non-communicable disease study-Agano (NICE EVIDENCE Study-Agano) 2. Reviewed International journal

Sakiko Yoshizawa Morikawa, Kazuya Fujihara, Mariko Hatta, Taeko Osawa, Masahiro Ishizawa, Masahiko Yamamoto, Kazuo Furukawa, Hajime Ishiguro, Satoshi Matsunaga, Yohei Ogawa, Hitoshi Shimano, Hirohito Sone

Pediatric diabetes 19 ( 4 ) 593 - 602 2018.6

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

OBJECTIVE: To examine the independent and combined associations of cardiorespiratory fitness (CRF) and muscular fitness (MF) with cardiometabolic risk factors in Japanese adolescents. METHODS: A cross-sectional study including 993 Japanese adolescents (aged 13-14 years) was undertaken. Height, body mass, blood pressure, lipid profile (non-fasting), and HbA1c were measured. The physical fitness (PF) test included measurements of CRF (20 m multistage shuttle run test), upper limb strength (hand grip strength), lower limb strength (standing long jump), and muscular endurance (sit-ups). The clustered cardiometabolic risk (CCMR) was estimated by summing standardized Z-scores of body mass index (BMI), mean arterial pressure (MAP), non-high-density lipoprotein cholesterol (non-HDL-C), and HbA1c. RESULTS: Linear regression analysis showed that all PF factors except for muscular endurance were inversely correlated with CCMR (P < .001). Among metabolic risk components, HbA1c was unrelated to PF, while non-HDL-C was inversely associated with CRF (B = -2.40; P < .001), upper limb strength (B = -1.77; P < .05), and lower limb strength (B = -1.53; P < .05) after adjustment for lifestyle factors. Logistic regression showed that the probability of having high CCMR (≥1SD) was synergistically higher in those with the lowest tertiles of both CRF and upper limb strength (P for interaction = .001); however, a substantially lower likelihood of having high CCMR was observed among individuals with the lowest tertile of upper limb strength but moderate CRF. CONCLUSIONS: Lower CRF and MF were significantly and synergistically associated with an unhealthier metabolic risk profile.

DOI： 10.1111/pedi.12623

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A distinct subtype of Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorder: adult patients with chronic active Epstein-Barr virus infection-like features. Reviewed International journal

Keisuke Kawamoto, Hiroaki Miyoshi, Takaharu Suzuki, Yasuji Kozai, Koji Kato, Masaharu Miyahara, Toshiaki Yujiri, Ilseung Choi, Katsumichi Fujimaki, Tsuyoshi Muta, Masaaki Kume, Sayaka Moriguchi, Shinobu Tamura, Takeharu Kato, Hiroyuki Tagawa, Junya Makiyama, Yuji Kanisawa, Yuya Sasaki, Daisuke Kurita, Kyohei Yamada, Joji Shimono, Hirohito Sone, Jun Takizawa, Masao Seto, Hiroshi Kimura, Koichi Ohshima

Haematologica 103 ( 6 ) 1018 - 1028 2018.6

Language：English Publishing type：Research paper (scientific journal)

The characteristics of adult patients with chronic active Epstein-Barr virus infection are poorly recognized, hindering early diagnosis and an improved prognosis. We studied 54 patients with adult-onset chronic active Epstein-Barr virus infection diagnosed between 2005 and 2015. Adult onset was defined as an estimated age of onset of 15 years or older. To characterize the clinical features of these adults, we compared them to those of 75 pediatric cases (estimated age of onset <15 years). We compared the prognosis of adult-onset chronic active Epstein-Barr virus infection with that of patients with nasal-type (n=37) and non-nasal-type (n=45) extranodal NK/T-cell lymphoma. The median estimated age of onset of these lymphomas was 39 years (range, 16-86 years). Compared to patients with pediatric-onset disease, those in whom the chronic active Epstein-Barr virus infection developed in adulthood had a significantly decreased incidence of fever (P=0.005), but greater frequency of skin lesions (P<0.001). Moreover, hypersensitivity to mosquito bites and the occurrence of hydroa vacciniforme were less frequent in patients with adult-onset disease (P<0.001 and P=0.0238, respectively). Thrombocytopenia, high Epstein-Barr virus nuclear antigen antibody titer, and the presence of hemophagocytic syndrome were associated with a poor prognosis (P=0.0087, P=0.0236, and P=0.0149, respectively). Allogeneic hematopoietic stem cell transplantation may improve survival (P=0.0289). Compared to pediatric-onset chronic active Epstein-Barr virus infection and extranodal NK/T-cell lymphoma, adult-onset chronic active Epstein-Barr virus infection had a poorer prognosis (P<0.001 and P=0.0484, respectively). Chronic active Epstein-Barr virus infection can develop in a wide age range, with clinical differences between adult-onset and pediatric-onset disease. Adult-onset chronic active Epstein-Barr virus infection is a disease with a poor prognosis. Further research will be needed.

DOI： 10.3324/haematol.2017.174177

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耐糖能及び肥満の有無別にみた代謝異常が冠動脈疾患発症に及ぼす影響の検討 Reviewed

藤原和哉, 松林泰弘, 山本正彦, 金子正儀, 松永佐澄志, 山田貴穂, 清田浩康, 山中菜詩, 児玉暁, 曽根博仁

日本動脈硬化学会総会プログラム・抄録集 50回 336 - 336 2018.6

眼科処置を要する重症糖尿病性眼疾患の発生リスクに対する腎症の影響についての検討 Reviewed

山本正彦, 藤原和哉, 大澤妙子, 原田万祐子, 石黒創, 石澤正博, 岩永みどり, 松永佐澄志, 松林泰弘, 清田浩康, 山中菜詩, 山田貴穂, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 161 2018.4

日本人2型糖尿病患者における、ビタミンB6摂取量と糖尿病網膜症発症との関係 JDCSによる報告 Reviewed

堀川千嘉, 相田麗, 田中司朗, 鎌田智恵実, 田中佐智子, 吉村幸雄, 川崎良, 山下英俊, 大橋靖雄, 井藤英喜, 赤沼安夫, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 141 2018.4

2型糖尿病患者における食事エネルギー密度と肥満との関連 JDDMにおける検討 Reviewed

武田安永, 藤原和哉, 治田麻理子, 森川咲子, 堀川千嘉, 石井大, 加藤光敏, 横山宏樹, 栗原義夫, 宮澤一裕, 岩崎晧一, 川井紘一, 朝長修, 屋宜宣治, 前川聡, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 265 2018.4

肥満境界型糖尿病患者に対する血糖自己測定と栄養指導媒体を用いた栄養教育の併用効果について Reviewed

長谷川美代, 堀川千嘉, 田代稔, 鈴木沙織, 藤原和哉, 北澤勝, 加藤公則, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 267 2018.4

指先穿刺による血糖およびHbA1c迅速測定をもちいた糖尿病啓発の取り組み Reviewed

山田貴穂, 石井大, 武田安永, 橋本浩平, 三ツ間友里恵, 張かおり, 原田万祐子, 白石友信, 吉岡大志, 山本正彦, 大澤妙子, 石黒創, 金子正儀, 鈴木浩史, 松林泰弘, 松永佐澄志, 藤原和哉, 岩永みどり, 鈴木亜希子, 羽入修, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 377 2018.4

糖尿病患者における脈圧が透析導入に及ぼす影響の検討 Reviewed

大澤妙子, 藤原和哉, 山本正彦, 原田万由子, 石澤正博, 清田浩康, 山中菜詩, 松林泰弘, 松永佐澄志, 山田貴穂, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 160 2018.4

診断に難渋した再発性重症低血糖の原因特定に薬物血中濃度測定が有用であった一例 Reviewed

三ツ間友里恵, 山本正彦, 橋本浩平, 金子正儀, 松林泰弘, 松永佐澄志, 山田貴穂, 岩永みどり, 藤原和哉, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 181 2018.4

糖尿病治療薬別にみたHbA1cと冠動脈疾患(CAD)発症リスクとの関連 Reviewed

原田万祐子, 藤原和哉, 大澤妙子, 石澤正博, 山本正彦, 金子正儀, 松林泰弘, 松永佐澄志, 山中菜詩, 清田浩康, 山田貴穂, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 258 2018.4

耐糖能及び肥満の有無に関わらず代謝異常は冠動脈疾患発症リスクを増大させる Reviewed

藤原和哉, 松林泰弘, 山本正彦, 松永佐澄志, 清田浩康, 山中菜詩, 児玉暁, 曽根博仁

糖尿病 61 ( Suppl.1 ) S - 260 2018.4

Cardiovascular Disease in Japanese Patients with Type 2 Diabetes Mellitus. Reviewed

Kazuya Fujihara, Hirohito Sone

Annals of vascular diseases 11 ( 1 ) 2 - 14 2018.3

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

Individuals with diabetes have a two- to four-fold increased risk of coronary artery disease (CAD) and higher mortality rates than those without diabetes. Because not only microvascular but also macrovascular disease in patients with diabetes are known to predispose patients to a lower quality of life as well as lead to higher mortality rates, identifying and managing risk factors of CAD is of clinical relevance in diabetes care. A number of antihyperglycemic drugs are currently approved for the treatment of hyperglycemia in patients with type 2 diabetes mellitus (T2DM), with several new drugs having been developed during the last decade. Diabetes-related complications have been substantially reduced worldwide. However, in view of the current situation in which both the prevalence of obesity and glucose abnormality have increased worldwide, including Japan, diet and exercise remain the crucial means of treatment for patients with diabetes. Furthermore, predicting the development of CAD is essential. This review summarizes data from recent studies on cardiovascular disease in patients with T2DM, focusing on clinical trials and big data, including studies involving Japanese individuals.

DOI： 10.3400/avd.ra.17-00109

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Predictors of the response of HbA1c and body weight after SGLT2 inhibition. Reviewed International journal

T Abe, Y Matsubayashi, A Yoshida, H Suganami, T Nojima, T Osawa, M Ishizawa, M Yamamoto, K Fujihara, S Tanaka, K Kaku, H Sone

Diabetes & metabolism 44 ( 2 ) 172 - 174 2018.3

MAGI-1 expression is decreased in several types of human T-cell leukemia cell lines, including adult T-cell leukemia. Reviewed

Takashi Kozakai, Masahiko Takahashi, Masaya Higuchi, Toshifumi Hara, Kousuke Saito, Yuetsu Tanaka, Masayoshi Masuko, Jun Takizawa, Hirohito Sone, Masahiro Fujii

International journal of hematology 107 ( 3 ) 337 - 344 2018.3

Role of fatty liver in the association between obesity and reduced hepatic insulin clearance. Reviewed International journal

Y Matsubayashi, A Yoshida, H Suganami, H Ishiguro, M Yamamoto, K Fujihara, S Kodama, S Tanaka, K Kaku, H Sone

Diabetes & metabolism 44 ( 2 ) 135 - 142 2018.3

Authorship：Corresponding author Language：English

AIM: Hepatic insulin clearance (HIC) is important in regulating plasma insulin levels. Diminished HIC causes inappropriate hyperinsulinaemia, and both obesity and fatty liver (FL), which are known to decrease HIC, can be found either together in the same patient or on their own. The mechanism by which obesity reduces HIC is presumed to be mediated by FL. However, few reports have examined the role of FL in the relationship between obesity and HIC in type 2 diabetes (T2D) patients. Therefore, our study investigated the association of HIC with clinical factors, including insulin sensitivity indices, focusing on the presence or absence of FL and obesity in T2D patients. METHOD: Baseline data from 419 patients with T2D (279 men, 140 women; mean age: 57.6 years; body mass index: 25.5kg/m2) controlled by diet and exercise were analyzed. HIC was calculated from the ratio of fasting c-peptide to fasting insulin levels (HICCIR). Correlation analyses between HICCIR and clinical variables were performed using Pearson's product-moment correlation coefficients and single regression analysis in all participants and in those with obesity and FL either alone or in combination. RESULTS: HICCIR was significantly correlated with whole-body insulin sensitivity indices and influenced by FL, but only in the FL group was obesity independently influenced HIC level. HICCIR decreased in those with both FL and obesity compared with those with only one such complication. CONCLUSION: HICCIR may be used to evaluate whole-body insulin sensitivity in T2D. Also, compared with obesity, the influence of FL strongly contributed to a reduced HIC. TRIAL REGISTRATION NUMBER: These trials were registered by the Japan Pharmaceutical Information Centre clinical trials information (JapicCTI) as 101349 and 101351.

DOI： 10.1016/j.diabet.2017.12.003

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Frequent expression of CD30 in extranodal NK/T-cell lymphoma: Potential therapeutic target for anti-CD30 antibody-based therapy. Reviewed International journal

Keisuke Kawamoto, Hiroaki Miyoshi, Takaharu Suzuki, Yuya Sasaki, Kyohei Yamada, Eriko Yanagida, Reiji Muto, Maiko Kiryu, Hirohito Sone, Masao Seto, Koichi Ohshima, Jun Takizawa

Hematological oncology 36 ( 1 ) 166 - 173 2018.2

Language：English Publishing type：Research paper (scientific journal)

Extranodal NK/T-cell lymphoma, nasal type (ENKTL) is a subtype of non-Hodgkin lymphoma with a poor prognosis. Although first-line treatments for patients with localized ENKTL have been established, there is no gold standard treatment for patients with advanced ENKTL and refractory and/or relapsed disease. Anti-CD30 antibody-based therapy, including brentuximab vedotin (BV), has been shown to target malignant lymphomas with CD30 expression. In particular, this therapeutic agent has recently been suggested to be effective for Hodgkin lymphoma and mature T-cell lymphoma. However, the efficacy of BV toward ENKTL has not yet been established. Therefore, we investigated the expression of CD30 in a large cohort to evaluate BV as a potential treatment for ENKTL. In this study, 97 Japanese patients with newly diagnosed ENKTL between January 2007 and December 2015 were enrolled. Flow cytometry and immunohistochemistry were performed for the evaluation of CD30 expression. If the cut-off value of CD30 expression is 1% or more, there were 55 positive cases (56.5%). According to the localization of lesion, the frequency of CD30 expression was significantly higher in the non-nasal type than in the nasal type (P = .0394). No differences were observed in almost all clinical characteristics between CD30-positive cases and CD30-negative cases. In addition, the expression of CD30 was not a prognostic factor for either overall survival or progression-free survival. In conclusion, frequent expression of CD30 in ENKTL suggests anti-CD30 antibody-based therapy may be an effective treatment.

DOI： 10.1002/hon.2482

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Quantitative Relationship Between Cumulative Risk Alleles Based on Genome-Wide Association Studies and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis. Reviewed

Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Nobumasa Ohara, Yoko Yachi, Shiro Tanaka, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

Journal of epidemiology 28 ( 1 ) 3 - 18 2018.1

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

Many epidemiological studies have assessed the genetic risk of having undiagnosed or of developing type 2 diabetes mellitus (T2DM) using several single nucleotide polymorphisms (SNPs) based on findings of genome-wide association studies (GWAS). However, the quantitative association of cumulative risk alleles (RAs) of such SNPs with T2DM risk has been unclear. The aim of this meta-analysis is to review the strength of the association between cumulative RAs and T2DM risk. Systematic literature searches were conducted for cross-sectional or longitudinal studies that examined odds ratios (ORs) for T2DM in relation to genetic profiles. Logarithm of the estimated OR (log OR) of T2DM for 1 increment in RAs carried (1-ΔRA) in each study was pooled using a random-effects model. There were 46 eligible studies that included 74,880 cases among 249,365 participants. In 32 studies with a cross-sectional design, the pooled OR for T2DM morbidity for 1-ΔRA was 1.16 (95% confidence interval [CI], 1.13-1.19). In 15 studies that had a longitudinal design, the OR for incident T2DM was 1.10 (95% CI, 1.08-1.13). There was large heterogeneity in the magnitude of log OR (P < 0.001 for both cross-sectional studies and longitudinal studies). The top 10 commonly used genes significantly explained the variance in the log OR (P = 0.04 for cross-sectional studies; P = 0.006 for longitudinal studies). The current meta-analysis indicated that carrying 1-ΔRA in T2DM-associated SNPs was associated with a modest risk of prevalent or incident T2DM, although the heterogeneity in the used genes among studies requires us to interpret the results with caution.

DOI： 10.2188/jea.JE20160151

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Impact of Prior Coronary Artery Disease (CAD) and Glucose Tolerance Status (GTS) on Incident CAD in Japanese Men

Hirohito Sone

Diabetes 2018

Commercially available elisa kit detects factor viii inhibitory antibodies earlier than bethesda assay, in severe hemophilia a patient with joint pain

Hirohito Sone

International Journal of Laboratory Hematology 2018

Impact of Carbohydrate Intake on Obesity in Japanese Patients with Type 2 Diabetes-An Analysis of the JDCP Registry

Hirohito Sone

Diabetes 2018

Association between Serum Amylase Level and Incidence of Type 2 Diabetes

Hirohito Sone

Diabetes 2018

Influence of SGLT2 Inhibitor on Resting Heart Rate (RHR) and Factors Related to Its Changes

Hirohito Sone

Diabetes 2018

当科で経験した下垂体茎断裂症候群の1例 Reviewed

佐藤隆明, 金子正儀, 福武嶺一, 安楽匠, 種村聡, 今西明, 矢口雄大, 山本正彦, 鈴木達郎, 石黒創, 松林泰弘, 山田貴穂, 岩永みどり, 藤原和哉, 曽根博仁

新潟医学会雑誌 132 ( 11/12 ) 399 - 399 2018

Reduced Postprandial Hepatic Insulin Clearance via the DPP-4 Inhibitor Anagliptin Contributed to Improvement in Hyperglycemia in Patients with Type 2 Diabetes Mellitus

Hirohito Sone

Diabetes 2018

Impact of body mass index and metabolic phenotypes on coronary artery disease according to glucose tolerance status. Reviewed International journal

K Fujihara, Y Matsubayashi, M Yamamoto, T Osawa, M Ishizawa, M Kaneko, S Matsunaga, K Kato, H Seida, N Yamanaka, S Kodama, H Sone

Diabetes & metabolism 43 ( 6 ) 543 - 546 2017.12

Authorship：Corresponding author Language：English

OBJECTIVE: This study aimed to examine the impact of obesity, as defined by body mass index (BMI), and a metabolically unhealthy phenotype on the development of coronary artery disease (CAD) according to glucose tolerance status. METHODS: This population-based retrospective cohort study included 123,746 Japanese men aged 18-72years (normal glucose tolerance: 72,047; prediabetes: 39,633; diabetes: 12,066). Obesity was defined as a BMI≥25kg/m2. Metabolically unhealthy individuals were defined as those with one or more of the following conditions: hypertension, hypertriglyceridaemia and/or low HDL cholesterol. A Cox proportional hazards regression model identified variables related to CAD incidence. RESULTS: The prevalences of obese subjects with normal glucose tolerance, prediabetes and diabetes were 21%, 34% and 53%, whereas those for metabolically unhealthy people were 43%, 60% and 79%, respectively. Multivariate analysis showed that a metabolically unhealthy phenotype increases hazard ratios (HRs) for CAD compared with a metabolically healthy phenotype, regardless of glucose tolerance status (normal glucose tolerance: 1.98, 95% CI: 1.32-2.95; prediabetes: 2.91, 95% CI: 1.85-4.55; diabetes: 1.90, 95% CI: 1.18-3.06). HRs for CAD among metabolically unhealthy non-obese diabetes patients and obese diabetes patients with a metabolically unhealthy status were 6.14 (95% CI: 3.94-9.56) and 7.86 (95% CI: 5.21-11.9), respectively, compared with non-obese subjects with normal glucose tolerance and without a metabolically unhealthy status. CONCLUSION: A metabolically unhealthy state can associate with CAD independently of obesity across all glucose tolerance stages. Clinicians may need to consider those with at least one or more conditions indicating a metabolically unhealthy state as being at high risk for CAD regardless of glucose tolerance status.

DOI： 10.1016/j.diabet.2017.08.002

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The Glasgow Prognostic Score as a pre-transplant risk assessment for allogeneic hematopoietic cell transplantation. Reviewed International journal

Yasuhiko Shibasaki, Tatsuya Suwabe, Takayuki Katagiri, Tomoyuki Tanaka, Hironori Kobayashi, Kyoko Fuse, Takashi Ushiki, Naoko Sato, Toshio Yano, Takashi Kuroha, Shigeo Hashimoto, Miwako Narita, Tatsuo Furukawa, Hirohito Sone, Masayoshi Masuko

Clinical transplantation 31 ( 11 ) 2017.11

Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies. Reviewed International journal

Tomoyuki Tanaka, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Shiro Tara, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Sha Si, Ichiro Manabe, Masashi Sanada, Manabu Nakayama, Masayoshi Masuko, Hirohito Sone, Haruhiko Koseki, Atsushi Iwama

The Journal of experimental medicine 214 ( 10 ) 2901 - 2913 2017.10

Severe hypoglycaemia is a major predictor of incident diabetic retinopathy in Japanese patients with type 2 diabetes Reviewed

S. Tanaka, R. Kawasaki, S. Tanaka-Mizuno, S. Iimuro, S. Matsunaga, T. Moriya, S. Ishibashi, S. Katayama, Y. Ohashi, Y. Akanuma, H. Sone, H. Yamashita

DIABETES & METABOLISM 43 ( 5 ) 424 - 429 2017.10

Comparative evaluation of torasemide and spironolactone on adverse cardiac remodeling in a rat model of dilated cardiomyopathy. Reviewed International journal

Somasundaram Arumugam, Remya Sreedhar, Vengadeshprabhu Karuppagounder, Meilei Harima, Masahiko Nakamura, Hiroshi Suzuki, Hirohito Sone, Kenichi Watanabe

Cardiovascular therapeutics 35 ( 5 ) 2017.10

Comprehensive risk management for the prevention of cerebro-cardiovascular diseases in Japan Reviewed

Tamio Teramoto, Masayuki Yokode, Hiroyasu Iso, Akihiko Kitamura, Hiroki Shiomi, Tsuyoshi Kimura, Masayasu Matsumoto, Mami Iida, Jun Sasaki, Shigeru Inoue, Ryouichi Nagatomi, Tetsuo Shoji, Hidenori Arai, Hiromi Rakugi, Hirohito Sone, Shizuya Yamashita, Shigeru Mizyzaki

CLINICAL AND EXPERIMENTAL NEPHROLOGY 21 ( 5 ) 743 - 754 2017.10

Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression. Reviewed International journal

Mohamed A E Ali, Kyoko Fuse, Yuko Tadokoro, Takayuki Hoshii, Masaya Ueno, Masahiko Kobayashi, Naho Nomura, Ha Thi Vu, Hui Peng, Ahmed M Hegazy, Masayoshi Masuko, Hirohito Sone, Fumio Arai, Atsushi Tajima, Atsushi Hirao

Scientific reports 7 ( 1 ) 11442 - 11442 2017.9

Successful 5-azacytidine treatment of myeloid sarcoma and leukemia cutis associated with myelodysplastic syndrome: A case report and literature review. Reviewed International journal

Takayuki Katagiri, Takashi Ushiki, Masayoshi Masuko, Tomoyuki Tanaka, Shukuko Miyakoshi, Kyoko Fuse, Yasuhiko Shibasaki, Jun Takizawa, Sadao Aoki, Hirohito Sone

Medicine 96 ( 36 ) e7975 2017.9

移植前予後予測モデルとしての同種造血細胞移植特異的Glasgow Prognostic Score(HCT specific Glasgow Prognostic Score as a new predictive tool for pre-transplant risk assessments)

Shibasaki Yasuhiko, Suwabe Tatsuya, Katagiri Takayuki, Tanaka Tomoyuki, Kobayashi Hironori, Fuse Kyoko, Ushiki Takashi, Narita Miwako, Sone Hirohito, Masuko Masayoshi

臨床血液 58 ( 9 ) 1547 - 1547 2017.9

Association between all-cause mortality and severity of depressive symptoms in patients with type 2 diabetes: Analysis from the Japan Diabetes Complications Study (JDCS). Reviewed International journal

Satoshi Matsunaga, Shiro Tanaka, Kazuya Fujihara, Chika Horikawa, Satoshi Iimuro, Masafumi Kitaoka, Asako Sato, Jiro Nakamura, Masakazu Haneda, Hitoshi Shimano, Yasuo Akanuma, Yasuo Ohashi, Hirohito Sone

Journal of psychosomatic research 99 34 - 39 2017.8

Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding beta-Cell Mass and Increasing Insulin Secretory Capacity Reviewed International journal

Hui Zhao, Takashi Matsuzaka, Yuta Nakano, Kaori Motomura, Nie Tang, Tomotaka Yokoo, Yuka Okajima, Song-iee Han, Yoshinori Takeuchi, Yuichi Aita, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Motohiro Sekiya, Naoya Yahagi, Yoshimi Nakagawa, Hirohito Sone, Nobuhiro Yamada, Hitoshi Shimano

DIABETES 66 ( 7 ) 1833 - 1846 2017.7

Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity

Zhao, Hui, Matsuzaka, Takashi, Nakano, Yuta, Motomura, Kaori, Tang, Nie, Yokoo, Tomotaka, Okajima, Yuka, Han, Song-Iee, Takeuchi, Yoshinori, Aita, Yuichi, Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Sekiya, Motohiro, Yahagi, Naoya, Nakagawa, Yoshimi, Sone, Hirohito, Yamada, Nobuhiro, Shimano, Hitoshi

Diabetes 66 ( 7 ) 1833 - 1846 2017.7

Impact of Obesity and Metabolic Phenotypes on Coronary Artery Disease (CAD) According to Glucose Tolerance Status Reviewed

Kazuya Fujihara, Satoru Kodama, Masahiko Yamamoto, Satoshi Matsunaga, Yasuhiro Matsubayashi, Masahiro Ishizawa, Mieko Koishi, Chie Ito, Nauta Yamanaka, Kiminori Kato, Hirohito Sone

DIABETES 66 A406 - A406 2017.6

Advanced Glycation End Products Induce Brain-Derived Neurotrophic Factor Release from Human Platelets through the Src Family Kinases Activation Reviewed

Kazuo Furukawa, Ichiro Fuse, Yuriko Iwakura, Hidekazu Sotoyama, Osamu Hanyu, Hiroyuki Nawa, Nobuyuki Takei, Hirohito Sone

DIABETES 66 A123 - A123 2017.6

Associations between Hypertension and End-Stage Renal Disease (ESRD) in People With and Without Diabetes Reviewed

Atsushi Furuya, Kazuya Fujihara, Masahiro Ishizawa, Masahiko Yamamoto, Yasuhiro Matsubayashi, Satoshi Matsunaga, Chie Ito, Mieko Koishi, Nauta Yamanaka, Kiminori Kato, Satoru Kodama, Hirohito Sone

DIABETES 66 A138 - A138 2017.6

Impact of glucose tolerance status on the development of coronary artery disease among working-age men. Reviewed

Fujihara K, Igarashi R, Yamamoto M, Ishizawa M, Matsubayasi Y, Matsunaga S, Kato K, Ito C, Koishi M, Yamanaka N, Kodama S, Sone H

DIABETES & METABOLISM 43 ( 3 ) 261 - 264 2017.6

Clinicopathological features of cryptococcal lymphadenitis and a review of literature. Reviewed

Kawamoto K, Miyoshi H, Suzuki T, Muto R, Yamada K, Yanagida E, Koshino M, Sasaki Y, Takizawa J, Sone H, Sugita Y, Seto M, Ohshima K

Journal of clinical and experimental hematopathology : JCEH 57 ( 1 ) 26 - 30 2017.6

Language：English Publishing type：Research paper (scientific journal)

Cryptococcosis is an invasive fungal infection in immunocompromised patients. The clinicopathological characteristics of cryptococcal lymphadenitis are not well known. We analyzed three cases of cryptococcal lymphadenitis and compared their characteristics with those in previous reports. Two patients were human immunodeficiency virus (HIV) carriers, and one patient was a human T-cell leukemia virus type-1 (HTLV-1) carrier. The age of the HTLV-1 carrier with cryptococcosis was much higher than that of the HIV-1 carriers. CD4-positive cell counts in peripheral blood were 5.8/μL (Case 1) and 79.9/μL (Case 2) in the HIV carriers and 3285/μL in the HTLV-1 carrier (Case 3). According to flow cytometric analysis of the lymph nodes of Cases 1, 2, and 3, 50.0%, 87.1%, and 85.9%, respectively, of the T-cells were CD3; 9.8%, 16.3%, and 75.8%, respectively, were CD4; and 35.5%, 77.3%, and 10.2%, respectively, were CD8. Cryptococcus neoformans was detected in tissue culture in all patients. Although gelatinous lesions and numerous fungal cocci were observed in the two HIV patients, the granuloma formation was small. Gelatinous formation and granuloma formation were observed in the HTLV-1 carrier. Necrosis was observed in all cases. In previous reports, granuloma formation, epithelioid cells, and necrotic lesions were observed in most cases. Most of the patients were also immunosuppressed. However, no HTLV-1 carrier was detected. In conclusion, lymphadenopathy in a HTLV-1 carrier may suggest the presence of cryptococcal lymphadenitis. The frequency of cryptococcosis in HTVL-1 carriers may increase with increase in the long-term survival rate of HTLV-1 carriers.

DOI： 10.3960/jslrt.17011

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Aggregation is a critical cause of poor transfer into the brain tissue of intravenously administered cationic PAMAM dendrimer nanoparticles Reviewed

Yoshika Kurokawa, Hideko Sone, Tin-Tin Win-Shwe, Yang Zeng, Hiroyuki Kimura, Yosuke Koyama, Yusuke Yagi, Yasuto Matsui, Masashi Yamazaki, Seishiro Hirano

International Journal of Nanomedicine 12 3967 - 3975 2017.5

Potential protective effect of lactation against incidence of type 2 diabetes mellitus in women with previous gestational diabetes mellitus: A systematic review and meta-analysis. Reviewed International journal

Tanase-Nakao K, Arata N, Kawasaki M, Yasuhi I, Sone H, Mori R, Ota E

Diabetes/metabolism research and reviews 33 ( 4 ) 2017.5

Comparison of clinicopathological characteristics between T-cell prolymphocytic leukemia and peripheral T-cell lymphoma, not otherwise specified. Reviewed International journal

Kawamoto K, Miyoshi H, Yanagida E, Yoshida N, Kiyasu J, Kozai Y, Morikita T, Kato T, Suzushima H, Tamura S, Muta T, Kato K, Eto T, Seki R, Nagafuji K, Sone H, Takizawa J, Seto M, Ohshima K

European journal of haematology 98 ( 5 ) 459 - 466 2017.5

Japanese Kampo Medicines for Diabetes Mellitus

Hiroshi Suzuki, Hirohito Sone, Kenichi Watanabe

Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation 69 - 73 2017.3

Comparative effects of torasemide and furosemide on gap junction proteins and cardiac fibrosis in a rat model of dilated cardiomyopathy. Reviewed International journal

Watanabe K, Sreedhar R, Thandavarayan RA, Karuppagounder V, Giridharan VV, Antony S, Harima M, Nakamura M, Suzuki K, Suzuki H, Sone H, Arumugam S

BioFactors (Oxford, England) 43 ( 2 ) 187 - 194 2017.3

Carbohydrate intake during early pregnancy is inversely associated with abnormal glucose challenge test results in Japanese pregnant women. Reviewed International journal

Tajima R, Yachi Y, Tanaka Y, Kawasaki YA, Nishibata I, Hirose AS, Horikawa C, Kodama S, Iida K, Sone H

Diabetes/metabolism research and reviews 33 ( 6 ) 2017.3

Dietary salt intake and diabetes complications in patients with diabetes: An overview. Reviewed

Chika Horikawa, Hirohito Sone

Journal of general and family medicine 18 ( 1 ) 16 - 20 2017.3

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

Dietary salt restriction is an essential constituent of diabetes care in preventing or slowing the development of diabetes complications, and many diabetes management guidelines include recommendations for dietary salt intake. However, descriptions of guidelines for salt intake are sometimes confined to studies of participants without diabetes or small short-term studies of patients with diabetes. However, in response to such situations, recent longitudinal studies of patients with diabetes have reported an association between dietary salt intake and diabetes complications. Thus, this review summarizes important points in the current situation regarding guidelines on salt intake and the latest findings and future issues on dietary salt intake for diabetes care focusing on (i) the current status and issues regarding the leading guidelines for dietary salt intake for diabetes care in various regions worldwide, and (ii) findings on salt intake from recent longitudinal studies of patients with diabetes whose dietary salt intake was restricted.

DOI： 10.1002/jgf2.10

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Patients with type 2 diabetes having higher glomerular filtration rate showed rapid renal function decline followed by impaired glomerular filtration rate: Japan Diabetes Complications Study. Reviewed International journal

Moriya T, Tanaka S, Sone H, Ishibashi S, Matsunaga S, Ohashi Y, Akanuma Y, Haneda M, Katayama S

Journal of diabetes and its complications 31 ( 2 ) 473 - 478 2017.2

Comparison of baseline characteristics and clinical course in Japanese patients with type 2 diabetes among whom different types of oral hypoglycemic agents were chosen by diabetes specialists as initial monotherapy (JDDM 42). Reviewed International journal

Fujihara K, Igarashi R, Matsunaga S, Matsubayashi Y, Yamada T, Yokoyama H, Tanaka S, Shimano H, Maegawa H, Yamazaki K, Kawai K, Sone H

Medicine 96 ( 7 ) e6122 2017.2

Is the Proportion of Carbohydrate Intake Associated with the Incidence of Diabetes Complications?-An Analysis of the Japan Diabetes Complications Study. Reviewed International journal

Horikawa C, Yoshimura Y, Kamada C, Tanaka S, Tanaka S, Matsunaga S, Hanyu O, Araki A, Ito H, Tanaka A, Ohashi Y, Akanuma Y, Sone H

Nutrients 9 ( 2 ) 2017.2

Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation. Reviewed International journal

Furukawa K, Fuse I, Iwakura Y, Sotoyama H, Hanyu O, Nawa H, Sone H, Takei N

Cardiovascular diabetology 16 ( 1 ) 20 - 20 2017.2

Unstable bodyweight and incident type 2 diabetes mellitus: A meta-analysis. Reviewed

Kodama S, Fujihara K, Ishiguro H, Horikawa C, Ohara N, Yachi Y, Tanaka S, Shimano H, Kato K, Hanyu O, Sone H

Journal of diabetes investigation 8 ( 4 ) 501 - 509 2017.1

Prevalence of non-communicable diseases and number of comorbidities according to differences in household income levels in Japan: Analysis from National Health and Nutrition Survey. Reviewed

Horikawa C, Murayama N, Ota A, Tsuruta M, Matsunaga S, Fujihara K, Hanyu O, Sone H

Food and nutrition Sciences 7 ( 1 ) 19 - 30 2017.1

Successful umbilical cord blood hematopoietic stem cell transplantation in a patient with adult T-cell leukemia/lymphoma initially achieving complete remission with anti-CC chemokine receptor 4 antibody combined chemotherapy. Reviewed

Suwabe T, Shibasaki Y, Kaihatsu A, Katagiri T, Miyakoshi S, Fuse K, Kobayashi H, Ushiki T, Moriyama M, Takizawa J, Narita M, Sone H, Masuko M

[Rinsho ketsueki] The Japanese journal of clinical hematology 58 ( 1 ) 32 - 36 2017

Language：Japanese Publishing type：Research paper (scientific journal)

A 62-year-old man with CHOP refractory adult T-cell leukemia/lymphoma (ATLL) received anti-CC chemokine receptor 4 antibody (mogamulizumab) combined with CHOP and achieved complete remission. At 71 days after the final administration of mogamulizumab, he received umbilical cord blood transplantation (CBT) using reduced intensity conditioning. Umbilical cord blood engraftment was confirmed on day16. Grade II acute graft-versus-host disease (GVHD) was diagnosed on day60 and was controlled by administration of methylprednisolone. There was no evidence of relapse at 9 months after CBT. Ratios of regulatory T cells in CD4 positive T cells were remarkably low during all of these periods. Since mogamulizumab reduces regulatory T cells, the frequency and severity of acute GVHD were reported to be increased in patients administered mogamulizumab before allogenic stem cell transplantation. Further experiences are needed for selecting optimal donor sources, the portability period and GVHD prophylaxis for patients using mogamulizumab before allogeneic stem cell transplantation.

DOI： 10.11406/rinketsu.58.32

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Peripheral T-cell lymphoma, not otherwise specified: a retrospective single-center analysis. Reviewed

Takaharu Suzuki, Keisuke Kawamoto, Suguru Tamura, Shun Uemura, Akane Kaihatsu, Hiroki Nemoto, Hironori Kobayashi, Takashi Ushiki, Kyoko Fuse, Yasuhiko Shibazaki, Masato Moriyama, Masayoshi Masuko, Miwako Narita, Hirohito Sone, Sadao Aoki, Naoya Nakamura, Koichi Oshima, Jun Takizawa

[Rinsho ketsueki] The Japanese journal of clinical hematology 58 ( 8 ) 905 - 911 2017

Language：Japanese Publishing type：Research paper (scientific journal)

We retrospectively analyzed clinical and pathological features, treatments, and prognoses in 28 patients with newly diagnosed peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) in Niigata University Medical and Dental Hospital. Of them, 16 were males and 12 were females, and their median age was 62.5 (range, 26-88) years. The International Prognostic Index was high-intermediate/high in 68% of patients. Twelve patients were treated with CHOP/THP-COP and nine with third-generation chemotherapy regimens. At a median follow-up period of 30 (range: 1-164) months, the 2-year overall survival and progression-free survival rates were 61% and 44%, respectively. Further investigation of novel agents for treating PTCL-NOS is warranted.

DOI： 10.11406/rinketsu.58.905

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[Myelodysplastic syndrome with refractory hemorrhage due to reduced platelet aggregation activity]. Reviewed

Tanaka T, Kozakai T, Kitajima T, Fuse K, Kobayashi H, Ushiki T, Shibazaki Y, Moriyama M, Takizawa J, Sone H, Fuse I, Masuko M

[Rinsho ketsueki] The Japanese journal of clinical hematology 58 ( 12 ) 2402 - 2405 2017

Language：Japanese Publisher：The Japanese Society of Hematology

A 75-year-old woman suffered a cat bite 10 months after myelodysplastic syndrome (MDS) diagnosis. She visited our hospital because the internal bleeding of the wound did not improve. Although the wound was treated, the bleeding did not stop. She was hospitalized for emergency medical treatment because the bleeding volume exceeded 200 ml. Although her platelet count was normal, the platelet function test showed a decrease in collagen and arachidonic acid aggregation. After platelet transfusion, her bleeding stopped. Patients with MDS may potentially have platelet dysfunction. In the case of bleeding without thrombocytopenia, a platelet function test should be performed and treatment intervention, such as platelet transfusion, should be considered.

DOI： 10.11406/rinketsu.58.2402

Other Link： http://search.jamas.or.jp/link/ui/2018121562

The SIL index is a simple and objective prognostic indicator in diffuse large B-cell lymphoma.

Tomita N, Suzuki T, Miyashita K, Yamamoto W, Motohashi K, Tachibana T, Takasaki H, Kawasaki R, Hagihara M, Hashimoto C, Takemura S, Koharazawa H, Yamazaki E, Taguchi J, Fujimaki K, Fujita H, Sakai R, Fujisawa S, Motomura S, Takizawa J

2016.12

Development and evaluation of the Japanese version of the Audit of Diabetes-Dependent Quality of Life for patients with diabetes. Reviewed

Ayumi Sugawara Hirose, Kazuya Fujihara, Flaminia Miyamasu, Shigeru Iwakabe, Misa Shimpo, Yoriko Heianza, Chika Horikawa, Yoko Yachi, Hirohito Sone

Diabetology international 7 ( 4 ) 384 - 390 2016.12

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

Objectives: Our objective was to undertake linguistic validation and cultural adaptation of the Japanese version of the Audit of Diabetes-Dependent Quality of Life (JP-ADDQoL) and to evaluate its psychometric properties when completed by Japanese patients with diabetes. Methods: We followed the standard linguistic validation procedure and subsequently evaluated the reliability (internal consistency) and construct validity (exploratory and confirmatory factor analyses) of the translated version by surveying 239 Japanese patients with diabetes. Results: We translated 19 items for the JP-ADDQoL. The internal consistency was excellent (Cronbach's alpha = 0.933). In the exploratory factor analysis, four factors were extracted, and most of the items in all four factors had high loadings. Forced one-factor analysis revealed all factor loadings other than those for sex life to be >0.40 (sex life: 0.398). Confirmatory factor analysis indicated an acceptable fit for the JP-ADDQoL. Conclusions: The JP-ADDQoL showed adequate reliability and acceptable validity. Examining not only the impact of diabetes on a specific domain of life but also its importance for each patient leads to more accurate and individualized measurement of the patient's QoL.

DOI： 10.1007/s13340-016-0260-4

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CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα. Reviewed International journal

Nakagawa Y, Satoh A, Tezuka H, Han SI, Takei K, Iwasaki H, Yatoh S, Yahagi N, Suzuki H, Iwasaki Y, Sone H, Matsuzaka T, Yamada N, Shimano H

Scientific reports 6 39182 - 39182 2016.12

Clinicopathological, Cytogenetic, and Prognostic Analysis of 131 Myeloid Sarcoma Patients. Reviewed International journal

Kawamoto K, Miyoshi H, Yoshida N, Takizawa J, Sone H, Ohshima K

The American journal of surgical pathology 40 ( 11 ) 1473 - 1483 2016.11

Quantitative assessment of genetic testing for type 2 diabetes mellitus based on findings of genome-wide association studies. Reviewed International journal

Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Nobumasa Ohara, Yoko Yachi, Shiro Tanaka, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

Annals of epidemiology 26 ( 11 ) 816 - 818 2016.11

Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression. Reviewed International journal

Kikuchi T, Orihara K, Oikawa F, Han SI, Kuba M, Okuda K, Satoh A, Osaki Y, Takeuchi Y, Aita Y, Matsuzaka T, Iwasaki H, Yatoh S, Sekiya M, Yahagi N, Suzuki H, Sone H, Nakagawa Y, Yamada N, Shimano H

Molecular metabolism 5 ( 11 ) 1092 - 1102 2016.11

Utility of nonblood-based risk assessment for predicting type 2 diabetes mellitus: A meta-analysis Reviewed International journal

Sakiko Yoshizawa, Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Masahiro Ishizawa, Yasuhiro Matsubayashi, Satoshi Matsunaga, Takaho Yamada, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

PREVENTIVE MEDICINE 91 180 - 187 2016.10

Association of eating three meals irregularly with changes in BMI and weight among young Japanese men and women: A 2-year follow-up. Reviewed International journal

Yoko Ibe, Happei Miyakawa, Yasuko Fuse-Nagase, Ayumi Sugawara Hirose, Reiko Hirasawa, Yoko Yachi, Kazuya Fujihara, Kazuto Kobayashi, Hitoshi Shimano, Hirohito Sone

Physiology & behavior 163 81 - 87 2016.9

Impact of individual components and their combinations within a family history of hypertension on the incidence of hypertension: Toranomon hospital health management center study 22. Reviewed International journal

Risa Igarashi, Kazuya Fujihara, Yoriko Heianza, Masahiro Ishizawa, Satoru Kodama, Kazumi Saito, Shigeko Hara, Osamu Hanyu, Ritsuko Honda, Hiroshi Tsuji, Yasuji Arase, Hirohito Sone

Medicine 95 ( 38 ) e4564 2016.9

輸血依存患者における肝臓内鉄含有量を評価するための二重エネルギーCTの重要性(Significance of dual-energy CT to evaluate liver iron content in transfusion-dependent patients)

Kobayashi Hironori, Yoshimura Norihiko, Suwabe Tatsuya, Katagiri Takayuki, Miyakoshi Shukuko, Ushiki Takashi, Fuse Kyoko, Shibasaki Yasuhiko, Moriyama Masato, Takizawa Jun, Narita Miwako, Sone Hirohito, Masuko Masayoshi

臨床血液 57 ( 9 ) 1524 - 1524 2016.9

Maximum BMI and microvascular complications in a cohort of Japanese patients with type 2 diabetes: the Japan Diabetes Complications Study Reviewed

Shiro Tanaka, Sachiko Tanaka, Satoshi Iimuro, Shun Ishibashi, Hidetoshi Yamashita, Tatsumi Moriya, Shigehiro Katayama, Yasuo Akanuma, Yasuo Ohashi, Nobuhiro Yamada, Atsushi Araki, Hideki Ito, Hirohito Sone

JOURNAL OF DIABETES AND ITS COMPLICATIONS 30 ( 5 ) 790 - 797 2016.7

Cluster-randomized trial to improve the quality of diabetes management: The study for the efficacy assessment of the standard diabetes manual (SEAS-DM). Reviewed

Hiroshi Noto, Yukio Tanizawa, Toru Aizawa, Hirohito Sone, Narihito Yoshioka, Yasuo Terauchi, Nobuya Inagaki, Mitsuhiko Noda

Journal of diabetes investigation 7 ( 4 ) 539 - 43 2016.7

Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system. Reviewed International journal

Yoshimi Nakagawa, Fusaka Oikawa, Seiya Mizuno, Hiroshi Ohno, Yuka Yagishita, Aoi Satoh, Yoshinori Osaki, Kenta Takei, Takuya Kikuchi, Song-Iee Han, Takashi Matsuzaka, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Naoya Yahagi, Masaaki Isaka, Hiroaki Suzuki, Hirohito Sone, Satoru Takahashi, Nobuhiro Yamada, Hitoshi Shimano

Scientific reports 6 27857 - 27857 2016.6

MYC translocation and/or BCL 2 protein expression are associated with poor prognosis in diffuse large B-cell lymphoma Reviewed

Keisuke Kawamoto, Hiroaki Miyoshi, Noriaki Yoshida, Naoya Nakamura, Koichi Ohshima, Hirohito Sone, Jun Takizawa

CANCER SCIENCE 107 ( 6 ) 853 - 861 2016.6

Body Mass Index (BMI), Waist Circumference (WC) and Waist Height Ratio (WHtR) Cutoff Values, and the Impact of Their Combinations on Future Diabetes among Japanese Individuals Reviewed

Risa Igarashi, Kazuya Fujihara, Yoriko Heianza, Masahiro Ishizawa, Megumi Tsuruta, Mariko Hatta, Sakiko Yoshizawa, Chika Hirikawa, Satoshi Matsunaga, Osamu Hanyu, Satoru Kodama, Koji Sato, Kiminori Kato, Hirohito Sone

DIABETES 65 A519 - A520 2016.6

The Dinakara equation for adjusting DLCO for hemoglobin in the HCT-CI is superior to the Cotes equation for predicting high-risk patients in allogeneic hematopoietic stem cell transplantation Reviewed

Yasuhiko Shibasaki, Takayuki Katagiri, Hironori Kobayashi, Takashi Ushiki, Miwako Narita, Hirohito Sone, Tatsuo Furukawa, Masayoshi Masuko

AMERICAN JOURNAL OF HEMATOLOGY 91 ( 5 ) E296 - E297 2016.5

[Features of Japanese diabetic macroangiopathy]. Reviewed

Masanori Kaneko, Kazuo Furukawa, Hirohito Sone

Nihon rinsho. Japanese journal of clinical medicine 74 Suppl 2 22 - 6 2016.4

[The 43rd Scientific Meeting: Perspectives of Internal Medicine; Genetic predisposition and related life-style underlying metabolic disorders; 2. Genetic and Environmental Susceptibility; 3) Epidemiology and large-scale clinical data analysis in metabolic diseases]. Reviewed

Hirohito Sone

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 105 ( 3 ) 383 - 90 2016.3

Comparison of clinical characteristics in patients with type 2 diabetes among whom different antihyperglycemic agents were prescribed as monotherapy or combination therapy by diabetes specialists. Reviewed

Kazuya Fujihara, Osamu Hanyu, Yoriko Heianza, Akiko Suzuki, Takaho Yamada, Hiroki Yokoyama, Shiro Tanaka, Hiroaki Yagyu, Hitoshi Shimano, Atsunori Kashiwagi, Katuya Yamazaki, Koichi Kawai, Hirohito Sone

Journal of diabetes investigation 7 ( 2 ) 260 - 9 2016.3

Assessment of kidney dysfunction with cystatin C- and creatinine-based estimated glomerular filtration rate and predicting type 2 diabetes: Toranomon Hospital Health Management Center Study 21 Reviewed

Yoriko Heianza, Shigeko Hara, Kazumi Saito, Hiroshi Tsuji, Shiro Tanaka, Satoru Kodama, Tetsuro Kobayashi, Yasuji Arase, Hirohito Sone

DIABETES RESEARCH AND CLINICAL PRACTICE 113 60 - 68 2016.3

Comparison of lipid parameters to predict cardiovascular events in Japanese mild-to-moderate hypercholesterolemic patients with and without type 2 diabetes: Subanalysis of the MEGA study Reviewed

Hirohito Sone, Tomoko Nakagami, Rimei Nishimura, Naoko Tajima

DIABETES RESEARCH AND CLINICAL PRACTICE 113 14 - 22 2016.3

Meta-analytic research on the relationship between cumulative risk alleles and risk of type 2 diabetes mellitus. Reviewed International journal

Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Nobumasa Ohara, Yoko Yachi, Shiro Tanaka, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone

Diabetes/metabolism research and reviews 32 ( 2 ) 178 - 86 2016.2

Effects of Chronic Low-Dose Radiation on Human Neural Progenitor Cells

Mari Katsura, Hiromasa Cyou-Nakamine, Qin Zen, Yang Zen, Hiroko Nansai, Shota Amagasa, Yasuharu Kanki, Tsuyoshi Inoue, Kiyomi Kaneki, Akashi Taguchi, Mika Kobayashi, Toshiyuki Kaji, Tatsuhiko Kodama, Kiyoshi Miyagawa, Youichiro Wada, Nobuyoshi Akimitsu, Hideko Sone

Scientific Reports 6 2016.1

In Search of the Ideal Resistance Training Program to Improve Glycemic Control and its Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis Reviewed

Hajime Ishiguro, Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Ayumi Sugawara Hirose, Reiko Hirasawa, Yoko Yachi, Nobumasa Ohara, Hitoshi Shimano, Osamu Hanyu, Hirohito Sone

SPORTS MEDICINE 46 ( 1 ) 67 - 77 2016.1

The SIL index is a simple and objective prognostic indicator in diffuse large B-cell lymphoma

Hirohito Sone

Leukemia & Lymphoma 2016

Rapid Normalization of High Glutamic Acid Decarboxylase Autoantibody Titers and Preserved Endogenous Insulin Secretion in a Patient with Diabetes Mellitus: A Case Report and Literature Review Reviewed

Nobumasa Ohara, Masanori Kaneko, Tatsuo Furukawa, Tadashi Koike, Hirohito Sone, Shoichiro Tanaka, Kenzo Kaneko, Kyuzi Kamoi

INTERNAL MEDICINE 55 ( 5 ) 485 - 489 2016

Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. Reviewed International journal

Noriko Suzuki-Kemuriyama, Takashi Matsuzaka, Motoko Kuba, Hiroshi Ohno, Song-Iee Han, Yoshinori Takeuchi, Masaaki Isaka, Kazuto Kobayashi, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Katsuhiro Miyajima, Dai Nakae, Naoya Yahagi, Yoshimi Nakagawa, Hirohito Sone, Nobuhiro Yamada, Hitoshi Shimano

PloS one 11 ( 6 ) e0157580 2016

Fulminant Type 1 Diabetes Mellitus Associated with Coxsackie Virus Type A2 Infection: A Case Report and Literature Review Reviewed

Nobumasa Ohara, Masanori Kaneko, Takeaki Nishibori, Kazuhiro Sato, Tatsuo Furukawa, Tadashi Koike, Hirohito Sone, Kenzo Kaneko, Kyuzi Kamoi

INTERNAL MEDICINE 55 ( 6 ) 643 - 646 2016

Fibromyalgia in a Patient with Cushing's Disease Accompanied by Central Hypothyroidism Reviewed

Nobumasa Ohara, Shinichi Katada, Takaho Yamada, Naomi Mezaki, Hiroshi Suzuki, Akiko Suzuki, Osamu Hanyu, Yuichiro Yoneoka, Izumi Kawachi, Takayoshi Shimohata, Akiyoshi Kakita, Masatoyo Nishizawa, Hirohito Sone

INTERNAL MEDICINE 55 ( 21 ) 3185 - 3190 2016

A case of hypoglycemia attributable to atypical antipsychotic drugs Reviewed

Hajime Ishiguro, Osamu Hanyu, Satoshi Houya, Kazuaki Morohashi, Ganji Kuroiwa, Osamu Kuwabara, Tsukasa Nakamaru, Katsuya Fuse, Kouji Sato, Hirohito Sone

Diabetology International 6 ( 4 ) 341 - 346 2015.12

Fatal tracheal aspergillosis during rituximab combined chemotherapy for diffuse large B-cell lymphoma that developed after lung transplantation Reviewed

K. Kawamoto, Y. Shibasaki, S. Sato, H. Nemoto, J. Takizawa, M. Narita, M. Tsuchida, H. Sone, M. Masuko

Transplant Infectious Disease 17 ( 6 ) 872 - 875 2015.12

[Clinical and pathophysiological features of Japanese patients with type 2 diabetes mellitus and their risk factors for diabetic complication]. Reviewed

Sone H

Nihon rinsho. Japanese journal of clinical medicine 73 ( 12 ) 1979 - 1987 2015.12

Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model Reviewed

Motoko Kuba, Takashi Matsuzaka, Rie Matsumori, Ryo Saito, Naoko Kaga, Hikari Taka, Kei Ikehata, Naduki Okada, Takuya Kikuchi, Hiroshi Ohno, Song-Iee Han, Yoshinori Takeuchi, Kazuto Kobayashi, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Hirohito Sone, Naoya Yahagi, Yoji Arakawa, Tsutomu Fujimura, Yoshimi Nakagawa, Nobuhiro Yamada, Hitoshi Shimano

SCIENTIFIC REPORTS 5 17604 2015.12

Clinical Significance of MYC, BCL2 and BCL6 Rearrangement and Protein Expression in GCB and Non-GCB Type Diffuse Large B-Cell Lymphoma Invited Reviewed

Keisuke Kawamoto, Jun Takizawa, Hiroaki Miyoshi, Noriaki Yoshida, Yasuhiko Shibasaki, Masayoshi Masuko, Hirohito Sone, Naoya Nakamura, Koichi Ohshima

BLOOD 126 ( 23 ) 2015.12

Risk factors associated with abnormal cognition in Japanese outpatients with diabetes, hypertension or dyslipidemia Reviewed

Hiroki Yokoyama, Mayumi Ogawa, Jun Honjo, Shinichiro Okizaki, Daishiro Yamada, Ryushi Shudo, Hitoshi Shimizu, Hirohito Sone, Masakazu Haneda

DIABETOLOGY INTERNATIONAL 6 ( 4 ) 268 - 274 2015.12

Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy Reviewed

Yoshinori Osaki, Yoshimi Nakagawa, Shoko Miyahara, Hitoshi Iwasaki, Akiko Ishii, Takashi Matsuzaka, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Naoya Yahagi, Hiroaki Suzuki, Hirohito Sone, Ken Ohashi, Shun Ishibashi, Nobuhiro Yamada, Hitoshi Shimano

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 466 ( 3 ) 536 - 540 2015.10

Prevalence of resistant hypertension and associated factors in Japanese subjects with type 2 diabetes

H. Yokoyama, S. Araki, S. Watanabe, J. Honjo, S. Okizaki, D. Yamada, R. Shudo, H. Shimizu, H. Sone, M. Haneda

DIABETES RESEARCH AND CLINICAL PRACTICE 110 ( 1 ) 18 - 25 2015.10

Impact of population aging on trends in diabetes prevalence: A meta-regression analysis of 160,000 Japanese adults Reviewed

Hadrien Charvat, Atsushi Goto, Maki Goto, Machiko Inoue, Yoriko Heianza, Yasuji Arase, Hirohito Sone, Tomoko Nakagami, Xin Song, Qing Qiao, Jaakko Tuomilehto, Shoichiro Tsugane, Mitsuhiko Noda, Manami Inoue

JOURNAL OF DIABETES INVESTIGATION 6 ( 5 ) 533 - 542 2015.9

Pioglitazone treatment and cardiovascular event and death in subjects with type 2 diabetes without established cardiovascular disease (JDDM 36)

H. Yokoyama, S. Araki, K. Kawai, K. Hirao, M. Oishi, K. Sugimoto, H. Sone, H. Maegawa, A. Kashiwagi

DIABETES RESEARCH AND CLINICAL PRACTICE 109 ( 3 ) 485 - 492 2015.9

HSCT後のγ/δT細胞低値およびTreg細胞高値はいずれも再発の独立リスク因子である(Both low γ/δ T cells and high Treg cells after HSCT is an independent risk factor for relapse)

Shibasaki Yasuhiko, Miyakoshi Syukuko, Suwabe Tatsuya, Katagiri Takayuki, Fuse Kyoko, Kobayashi Hironori, Ushiki Takashi, Moriyama Masato, Takizawa Jun, Narita Miwako, Sone Hirohito, Furukawa Tatsuo, Masuko Masayoshi

臨床血液 56 ( 9 ) 1666 - 1666 2015.9

レシピエントに対する移植前評価としてのHCT-CI/年齢スコアの臨床的意義(The clinical relevance of HCT-CI/age score as pre-transplant assessment for recipients)

Katagiri Takayuki, Shibasaki Yasuhiko, Suwabe Tatsuya, Miyakoshi Shukuko, Fuse Kyoko, Kobayashi Hironori, Ushiki Takashi, Moriyama Masato, Takizawa Jun, Narita Miwako, Sone Hirohito, Masuko Masayoshi

臨床血液 56 ( 9 ) 1665 - 1665 2015.9

DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis

Naoki Kubo, Hidehiro Toh, Kenjiro Shirane, Takayuki Shirakawa, Hisato Kobayashi, Tetsuya Sato, Hidetoshi Sone, Yasuyuki Sato, Shin-Ichi Tomizawa, Yoshinori Tsurusaki, Hiroki Shibata, Hirotomo Saitsu, Yutaka Suzuki, Naomichi Matsumoto, Mikita Suyama, Tomohiro Kono, Kazuyuki Ohbo, Hiroyuki Sasaki

BMC Genomics 16 ( 1 ) 2015.8

Possible Involvement of Lung Cells Harboring an Abnormal Karyotype in the Pathogenesis of Pulmonary Alveolar Proteinosis Associated with Myelodysplastic Syndrome. Reviewed

Moriyama M, Yano T, Furukawa T, Takada T, Ushiki T, Masuko M, Takizawa J, Sone H, Tazawa R, Saijo Y, Ishii H, Nakata K

Annals of the American Thoracic Society 12 ( 8 ) 1251 - 1253 2015.8

The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling

Wilhelm Engström, Philippa Darbre, Staffan Eriksson, Linda Gulliver, Tove Hultman, Michalis V. Karamouzis, James E. Klaunig, Rekha Mehta, Kim Moorwood, Thomas Sanderson, Hideko Sone, Pankaj Vadgama, Gerard Wagemaker, Andrew Ward, Neetu Singh, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Anna Maria Colacci, Monica Vaccari, Chiara Mondello, A. Ivana Scovassi, Jayadev Raju, Roslida A. Hamid, Lorenzo Memeo, Stefano Forte, Rabindra Roy, Jordan Woodrick, Hosni K. Salem, Elizabeth Ryan, Dustin G. Brown, William H. Bisson

Carcinogenesis 36 S38 - S60 2015.6

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: The challenge ahead

William H. Goodson, Leroy Lowe, David O. Carpenter, Michael Gilbertson, Abdul Manaf Ali, Adela Lopez de Cerain Salsamendi, Ahmed Lasfar, Amancio Carnero, Amaya Azqueta, Amedeo Amedei, Amelia K. Charles, Andrew R. Collins, Andrew Ward, Anna C. Salzberg, Annamaria Colacci, Ann-Karin Olsen, Arthur Berg, Barry J. Barclay, Binhua P. Zhou, Carmen Blanco-Aparicio, Carolyn J. Baglole, Chenfang Dong, Chiara Mondello, Chia-Wen Hsu, Christian C. Naus, Clement Yedjou, Colleen S. Curran, Dale W. Laird, Daniel C. Koch, Danielle J. Carlin, Dean W. Felsher, Debasish Roy, Dustin G. Brown, Edward Ratovitski, Elizabeth P. Ryan, Emanuela Corsini, Emilio Rojas, Eun-Yi Moon, Ezio Laconi, Fabio Marongiu, Fahd Al-Mulla, Ferdinando Chiaradonna, Firouz Darroudi, Francis L. Martin, Frederik J. Van Schooten, Gary S. Goldberg, Gerard Wagemaker, Gladys Nangami, Gloria M. Calaf, Graeme Williams, Gregory T. Wolf, Gudrun Koppen, Gunnar Brunborg, H. Kim Lyerly, Harini Krishnan, Hasiah Ab Hamid, Hemad Yasaei, Hideko Sone, Hiroshi Kondoh, Hosni K. Salem, Hsue-Yin Hsu, Hyun Ho Park, Igor Koturbash, Isabelle R. Miousse, A. Ivana Scovassi, James E. Klaunig, Jan Vondráček, Jayadev Raju, Jesse Roman, John Pierce Wise, Jonathan R. Whitfield, Jordan Woodrick, Joseph A. Christopher, Josiah Ochieng, Juan Fernando Martinez-Leal, Judith Weisz, Julia Kravchenko, Jun Sun, Kalan R. Prudhomme, Kannan Badri Narayanan, Karine A. Cohen-Solal, Kim Moorwood, Laetitia Gonzalez, Laura Soucek, Le Jian, Leandro S. D'Abronzo, Liang-Tzung Lin, Lin Li, Linda Gulliver, Lisa J. McCawley, Lorenzo Memeo, Louis Vermeulen, Luc Leyns, Luoping Zhang, Mahara Valverde, Mahin Khatami, Maria Fiammetta Romano, Marion Chapellier, Marc A. Williams, Mark Wade, Masoud H. Manjili, Matilde Lleonart, Menghang Xia, Michael J. Gonzalez, Michalis V. Karamouzis, Micheline Kirsch-Volders, Monica Vaccari, Nancy B. Kuemmerle, Neetu Singh, Nichola Cruickshanks, Nicole Kleinstreuer, Nik Van Larebeke, Nuzhat Ahmed, Olugbemiga Ogunkua, P. K. Krishnakumar, Pankaj Vadgama, Paola A. Marignani, Paramita M. Ghosh, Patricia Ostrosky-Wegman, Patricia Thompson, Paul Dent, Petr Heneberg, Philippa Darbre, Po Sing Leung, Pratima Nangia-Makker, Qiang Shawn Cheng, R. Brooks Robey, Rabeah Al-Temaimi, Rabindra Roy, Rafaela Andrade-Vieira, Ranjeet K. Sinha, Rekha Mehta, Renza Vento, Riccardo Di Fiore, Richard Ponce-Cusi, Rita Dornetshuber-Fleiss, Rita Nahta, Robert C. Castellino, Roberta Palorini, Roslida Abd Hamid, Sabine A.S. Langie, Sakina Eltom, Samira A. Brooks, Sandra Ryeom, Sandra S. Wise, Sarah N. Bay, Shelley A. Harris, Silvana Papagerakis, Simona Romano, Sofia Pavanello, Staffan Eriksson, Stefano Forte, Stephanie C. Casey, Sudjit Luanpitpong, Tae-Jin Lee, Takemi Otsuki, Tao Chen, Thierry Massfelder, Thomas Sanderson, Tiziana Guarnieri, Tove Hultman, Valérian Dormoy, Valerie Odero-Marah, Venkata Sabbisetti, Veronique Maguer-Satta, W. Kimryn Rathmell, Wilhelm Engström, William K. Decker, William H. Bisson, Yon Rojanasakul, Yunus Luqmani, Zhenbang Chen, Zhiwei Hu

Carcinogenesis 36 S254 - S296 2015.6

The association of level of reduction of Wilms' tumor gene 1 mRNA transcript in bone marrow and outcome in acute myeloid leukemia patients Reviewed

Yasuhiko Shibasaki, Yoshinobu Seki, Tomoyuki Tanaka, Syukuko Miyakoshi, Kyoko Fuse, Takashi Kozakai, Hironori Kobayashi, Takashi Ushiki, Takashi Abe, Toshio Yano, Masato Moriyama, Takashi Kuroha, Noriatsu Isahai, Jun Takizawa, Miwako Narita, Satoru Koyama, Tatsuo Furukawa, Hirohito Sone, Masayoshi Masuko

LEUKEMIA RESEARCH 39 ( 6 ) 667 - 671 2015.6

Risk of the development of Type 2 diabetes in relation to overall obesity, abdominal obesity and the clustering of metabolic abnormalities in Japanese individuals: does metabolically healthy overweight really exist? The Niigata Wellness Study Reviewed

Y. Heianza, K. Kato, S. Kodama, N. Ohara, A. Suzuki, S. Tanaka, O. Hanyu, K. Sato, H. Sone

DIABETIC MEDICINE 32 ( 5 ) 665 - 672 2015.5

Correlation between SNP genotypes and periodontitis in Japanese type II diabetic patients: a preliminary study Reviewed

Teerasak Damrongrungruang, Hiroshi Ogawa, Sayaka Hori-Matsumoto, Kumiko Minagawa, Osamu Hanyu, Hirohito Sone, Hideo Miyazaki

ODONTOLOGY 103 ( 2 ) 233 - 240 2015.5

Trajectory of body mass index before the development of type 2 diabetes in Japanese men: Toranomon Hospital Health Management Center Study 15 Reviewed

Yoriko Heianza, Yasuji Arase, Satoru Kodama, Hiroshi Tsuji, Shiro Tanaka, Kazumi Saito, Shigeko Hara, Hirohito Sone

Journal of Diabetes Investigation 6 ( 3 ) 289 - 294 2015.5

Fasting glucose and HbA1c levels as risk factors for the development of hypertension in Japanese individuals: Toranomon hospital health management center study 16 (TOPICS 16) Reviewed

Y. Heianza, Y. Arase, S. Kodama, S. D. Hsieh, H. Tsuji, K. Saito, S. Hara, H. Sone

Journal of Human Hypertension 29 ( 4 ) 254 - 259 2015.4

Simple self-reported behavioral or psychological characteristics as risk factors for future type 2 diabetes in Japanese individuals: Toranomon Hospital Health Management Center Study 14 Reviewed

Yoriko Heianza, Yasuji Arase, Satoru Kodama, Hiroshi Tsuji, Kazuya Fujihara, Kazumi Saito, Shigeko Hara, Hirohito Sone

JOURNAL OF DIABETES INVESTIGATION 6 ( 2 ) 236 - 241 2015.3

Potential impact of joint association of alanine aminotransferase and gamma-glutamyltransferase on insulin resistance in Japan: The Toranomon Hospital Health Management Center Study 19 (TOPICS 19) Reviewed

Yasuji Arase, Yoriko Heianza, Shigeko Hara, Yuki Ohmoto-Sekine, Kazuhisa Amakawa, Hiroshi Tsuji, Kyoko Ogawa, Kazumi Saito, Satoru Kodama, Kenji Ikeda, Hiromitsu Kumada, Tetsuro Kobayashi, Hirohito Sone

HEPATOLOGY RESEARCH 45 ( 3 ) 247 - 258 2015.3

The Combination of Elevated Triglycerides and Abnormal Fasting Glucose Increases Risk of Cerebral Infarction in Patients With Mild to Moderate Hypercholesterolemia: A Post Hoc Analysis of the MEGA Study Reviewed

Tomoko Nakagami, Rimei Nishimura, Hirohito Sone, Naoko Tajima

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS 20 ( 2 ) 169 - 173 2015.3

Reply to: Relationship between leptin and blood pressure in patients with multiple system atrophy Reviewed

Tetsutaro Ozawa, Hirohito Sone, Masatoyo Nishizawa

Journal of the Neurological Sciences 348 ( 1-2 ) 285 2015.1

Cardioprotective Food Function as Underpinning Strategy for Disease Prevention Dietary Antioxidants in Diabetic Cardiac Complications

Hirohito Sone

Clinical Aspects of Functional Foods and Nutraceuticals 2015

Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes Reviewed

Kazuya Fujihara, Hiroaki Suzuki, Akira Sato, Satoru Kodama, Yoriko Heianza, Kazumi Saito, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Naoya Yahagi, Hiroaki Yagyu, Hirohito Sone, Hitoshi Shimano

JOURNAL OF DIABETES RESEARCH 2015 507245 2015

Type 1 Diabetes Mellitus and Isolated Adrenocorticotropin Deficiency Manifested by Parkinsonism: A Case Report and Literature Review Reviewed

Nobumasa Ohara, Naoyuki Kojima, Takashi Sato, Tomoo Ikarashi, Hirohito Sone, Yutaka Oki, Kyuzi Kamoi, Masao Hara, Hideo Sasaki

INTERNAL MEDICINE 54 ( 20 ) 2629 - 2635 2015

Late Onset Post-Transfusion Hepatitis E Developing during Chemotherapy for Acute Promyelocytic Leukemia Reviewed

Kyoko Fuse, Yuichi Matsuyama, Masato Moriyama, Shukuko Miyakoshi, Yasuhiko Shibasaki, Jun Takizawa, Tatsuo Furukawa, Ichiro Fuse, Hiro Matsumura, Shigeharu Uchida, Yoshifumi Takahashi, Kenya Kamimura, Hiroyuki Abe, Takeshi Suda, Yutaka Aoyagi, Hirohito Sone, Masayoshi Masuko

INTERNAL MEDICINE 54 ( 6 ) 657 - 661 2015

The factors that affect exercise therapy for patients with type 2 diabetes in Japan: a nationwide survey Reviewed

S. Arakawa, T. Watanabe, H. Sone, Y. Tamura, M. Kobayashi, R. Kawamori, Y. Atsumi, Y. Oshida, S. Tanaka, S. Suzuki, S. Makita, I. Ohsawa, Yuzo Sato

Diabetology International 6 ( 1 ) 19 - 25 2015

Current situation of exercise therapy in patients with diabetes mellitus in Japan (report no. 2): A nationwide survey to patients using the questionnaires

Yuzo Sato, Hirohito Sone, Masashi Kobayashi, Ryuzo Kawamori, Yoshihito Atsumi, Yoshiharu Oshida, Shiro Tanaka, Susumu Suzuki, Shigeru Makita, Isao Ohsawa, Yoshifumi Tamura, Tomoyuki Watanabe

Journal of the Japan Diabetes Society 58 ( 11 ) 850 - 859 2015

Imaging of Body Iron Stores in Transfusion-Dependent Patients By Liver Dual-Energy CT Reviewed

Hironori Kobayashi, Norihiko Yoshimura, Takashi Ushiki, Yasuhiko Shibasaki, Masato Moriyama, Jun Takizawa, Miwako Narita, Hirohito Sone, Masayoshi Masuko

BLOOD 124 ( 21 ) 2014.12

Efficacy of HMG-CoA reductase inhibitors in the prevention of cerebrovascular attack in 1016 patients older than 75 years among 4014 type 2 diabetic individuals Reviewed

Toshio Hayashi, Kiyoshi Kubota, Seinosuke Kawashima, Hirohito Sone, Hiroshi Watanabe, Takashi Ohrui, Koutaro Yokote, Minoru Takemoto, Atsushi Araki, Mitsuhiko Noda, Hiroshi Noto, Ichiro Sakuma, Masao Yoshizumi, Koichiro Ina, Hideki Nomura

INTERNATIONAL JOURNAL OF CARDIOLOGY 177 ( 3 ) 860 - 866 2014.12

Impact on short-term glycaemic control of initiating diabetes care versus leaving diabetes untreated among individuals with newly screening-detected diabetes in Japan Reviewed

Yoriko Heianza, Akiko Suzuki, Kazuya Fujihara, Shiro Tanaka, Satoru Kodama, Osamu Hanyu, Hirohito Sone

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH 68 ( 12 ) 1189 - 1195 2014.12

Body Mass Index and Mortality Among Japanese Patients With Type 2 Diabetes: Pooled Analysis of the Japan Diabetes Complications Study and the Japanese Elderly Diabetes Intervention Trial Reviewed

Shiro Tanaka, Sachiko Tanaka, Satoshi Iimuro, Yasuo Akanuma, Yasuo Ohashi, Nobuhiro Yamada, Atsushi Araki, Hideki Ito, Hirohito Sone

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99 ( 12 ) E2692 - E2696 2014.12

Hepatic CREB3L3 Controls Whole-Body Energy Homeostasis and Improves Obesity and Diabetes Reviewed

Yoshimi Nakagawa, Aoi Satoh, Sachiko Yabe, Mika Furusawa, Naoko Tokushige, Hitomi Tezuka, Motoki Mikami, Wakiko Iwata, Akiko Shingyouchi, Takashi Matsuzaka, Shiori Kiwata, Yuri Fujimoto, Hidehisa Shimizu, Hirosuke Danno, Takashi Yamamoto, Kiyoaki Ishii, Tadayoshi Karasawa, Yoshinori Takeuchi, Hitoshi Iwasaki, Masako Shimada, Yasushi Kawakami, Osamu Urayama, Hirohito Sone, Kazuhiro Takekoshi, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Naoya Yahagi, Hiroaki Suzuki, Nobuhiro Yamada, Hitoshi Shimano

ENDOCRINOLOGY 155 ( 12 ) 4706 - 4719 2014.12

Log Reduction Levels of WT1 mRNA Expression in BM after Chemotherapies Are Predictive Markers of Good Prognosis in AML Patients Achieved CR after Induction Therapy Reviewed

BLOOD 124 ( 21 ) 2014.12

High cholesterol intake is associated with elevated risk of type 2 diabetes mellitus - A meta-analysis(1-4) Reviewed

Ryoko Tajima, Satoru Kodama, Miho Hirata, Chika Horikawa, Kazuya Fujihara, Yoko Yachi, Sakiko Yoshizawa, Kaoruko Tada Iida, Hirohito Sone

CLINICAL NUTRITION 33 ( 6 ) 946 - 950 2014.12

The circulating level of leptin and blood pressure in patients with multiple system atrophy Reviewed

Tetsutaro Ozawa, Jun Tokunaga, Musashi Arakawa, Atsushi Ishikawa, Ryoko Takeuchi, Akio Yokoseki, Hirohito Sone, Masatoyo Nishizawa

JOURNAL OF THE NEUROLOGICAL SCIENCES 347 ( 1-2 ) 349 - 351 2014.12

Stability and Changes in Metabolically Healthy Overweight or Obesity and Risk of Future Diabetes: Niigata Wellness Study Reviewed

Yoriko Heianza, Kiminori Kato, Satoru Kodama, Akiko Suzuki, Shiro Tanaka, Osamu Hanyu, Koji Sato, Hirohito Sone

OBESITY 22 ( 11 ) 2420 - 2425 2014.11

Role of sleep duration as a risk factor for Type 2 diabetes among adults of different ages in Japan: the Niigata Wellness Study Reviewed

Y. Heianza, K. Kato, K. Fujihara, S. Tanaka, S. Kodama, O. Hanyu, K. Sato, H. Sone

DIABETIC MEDICINE 31 ( 11 ) 1363 - 1367 2014.11

High risk of failing eradication of Helicobacter pylori in patients with diabetes: A meta-analysis Reviewed

Chika Horikawa, Saroru Kodama, Kazuya Fujihara, Reiko Hirasawa, Yoko Yachi, Akiko Suzuki, Osamu Hanyu, Hitoshi Shimano, Hirohito Sone

DIABETES RESEARCH AND CLINICAL PRACTICE 106 ( 1 ) 81 - 87 2014.10

Dietary Sodium Intake and Incidence of Diabetes Complications in Japanese Patients with Type 2 Diabetes: Analysis of the Japan Diabetes Complications Study (JDCS) Reviewed

Chika Horikawa, Yukio Yoshimura, Chiemi Kamada, Shiro Tanaka, Sachiko Tanaka, Osamu Hanyu, Atsushi Araki, Hideki Ito, Akira Tanaka, Yasuo Ohashi, Yasuo Akanuma, Nobuhiro Yamada, Hirohito Sone

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99 ( 10 ) 3635 - 3643 2014.10

Importance of high-density lipoprotein cholesterol levels in elderly diabetic individuals with type IIb dyslipidemia: A 2-year survey of cardiovascular events Reviewed

Koichiro Ina, Toshio Hayashi, Atsushi Araki, Seinosuke Kawashima, Hirohito Sone, Hiroshi Watanabe, Takashi Ohrui, Koutaro Yokote, Minoru Takemoto, Kiyoshi Kubota, Mitsuhiko Noda, Hiroshi Noto, Qun-Fang Ding, Jie Zhang, Ze-Yun Yu, Byung-Koo Yoon, Hideki Nomura, Masafumi Kuzuya

GERIATRICS & GERONTOLOGY INTERNATIONAL 14 ( 4 ) 806 - 810 2014.10

A possible link between BDNF and mTOR in control of food intake Reviewed

Nobuyuki Takei, Kazuo Furukawa, Osamu Hanyu, Hirohito Sone, Hiroyuki Nawa

FRONTIERS IN PSYCHOLOGY 5 1093 2014.9

Second trimester postload glucose level as an important predictor of low birth weight infants: Tanaka Women's Clinic Study Reviewed

Yoko Yachi, Yasuhiro Tanaka, Izumi Nishibata, Sakiko Yoshizawa, Kazuya Fujihara, Satoru Kodama, Akiko Suzuki, Osamu Hanyu, Hirohito Sone

DIABETES RESEARCH AND CLINICAL PRACTICE 105 ( 3 ) E16 - E19 2014.9

Fasting mediated increase in p-BAD(ser155) and p-AKT(ser473) in the prefrontal cortex of mice Reviewed

Vigneshwaran Pitchaimani, Somasundaram Arumugam, Rajarajan Amirthalingam Thandavarayan, Vengadeshprabhu Karuppagounder, Remya Sreedhar, Rejina Afrin, Meilei Harima, Hiroshi Suzuki, Shizuka Miyashita, Mayumi Nomoto, Hirohito Sone, Kenji Suzuki, Kenichi Watanabe

NEUROSCIENCE LETTERS 579 134 - 139 2014.9

Activation of the Leukemia Plasmacytoid Dendritic Cell Line PMDC05 by Toho-1, a Novel IDO Inhibitor Reviewed

Akie Yamahira, Miwako Narita, Minami Iwabuchi, Takayoshi Uchiyama, Shunpei Iwaya, Rie Ohiwa, Yoshinori Nishizawa, Takafumi Suzuki, Yusaku Yokoyama, Shigeo Hashimoto, Jun Takizawa, Hirohito Sone, Masuhiro Takahashi

ANTICANCER RESEARCH 34 ( 8 ) 4021 - 4028 2014.8

Metabolically Healthy Obesity, Presence or Absence of Fatty Liver, and Risk of Type 2 Diabetes in Japanese Individuals: Toranomon Hospital Health Management Center Study 20 (TOPICS 20) Reviewed

Yoriko Heianza, Yasuji Arase, Hiroshi Tsuji, Kazuya Fujihara, Kazumi Saito, Shiun Dong Hsieh, Shiro Tanaka, Satoru Kodama, Shigeko Hara, Hirohito Sone

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99 ( 8 ) 2952 - 2960 2014.8

Role of Body Mass Index History in Predicting Risk of the Development of Hypertension in Japanese Individuals Toranomon Hospital Health Management Center Study 18 (TOPICS 18) Reviewed

Yoriko Heianza, Satoru Kodama, Yasuji Arase, Shiun Dong Hsieh, Sakiko Yoshizawa, Hiroshi Tsuji, Kazumi Saito, Shiro Tanaka, Shigeko Hara, Hirohito Sone

HYPERTENSION 64 ( 2 ) 247 - + 2014.8

Cohort Profile: The Japan Diabetes Complications Study: a long-term follow-up of a randomised lifestyle intervention study of type 2 diabetes Reviewed

Shiro Tanaka, Sachiko Tanaka, Satoshi Iimuro, Hidetoshi Yamashita, Shigehiro Katayama, Yasuo Ohashi, Yasuo Akanuma, Nobuhiro Yamada, Hirohito Sone

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 43 ( 4 ) 1054 - 1062 2014.8

[Successful treatment with bortezomib in a patient with systemic primary AL amyloidosis manifesting severe gastrointestinal bleeding]. Reviewed

Ida T, Hayashi K, Ida T, Hirano S, Nakamura F, Sone H, Fujiwara M

[Rinsho ketsueki] The Japanese journal of clinical hematology 55 ( 7 ) 808 - 814 2014.7

Language：Japanese Publishing type：Research paper (scientific journal)

We present a systemic primary AL amyloidosis patient with severe gastrointestinal bleeding for whom treatment with bortezomib and dexamethasone was very effective. An 83-year-old woman was admitted to our hospital suffering from multiple gastric ulcers with bleeding. She had monoclonal protein (IgG, λ) in her serum. Systemic primary AL amyloidosis was diagnosed. She was also suspected of having amyloid deposition in cardiac muscle, as well as her bladder and intestinal mucosa. However, we were unable to carry out other invasive examinations due to her bleeding tendency. She was treated with bortezomib and dexamethasone. Her bleeding tendency gradually diminished. After one year, the bleeding tendency had completely resolved. However, she still had amyloid deposition in her gastric mucosa and skin.

DOI： 10.11406/rinketsu.55.808

PubMed

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Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion Reviewed

Nie Tang, Takashi Matsuzaka, Marii Suzuki, Yuta Nakano, Hui Zao, Tomotaka Yokoo, Noriko Suzuki-Kemuriyama, Motoko Kuba, Yuka Okajima, Yoshinori Takeuchi, Kazuto Kobayashi, Hitoshi Iwasaki, Shigeru Yatoh, Akimitsu Takahashi, Hiroaki Suzuki, Hirohito Sone, Masako Shimada, Yoshimi Nakagawa, Naoya Yahagi, Nobuhiro Yamada, Hitoshi Shimano

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 450 ( 1 ) 318 - 323 2014.7

Food groups and weight gain in Japanese men.

Ibe Y, Takahashi Y, Sone H

2014.6

Commentary on the United Kingdom Prospective Diabetes Study outcomes model 2: Need for long-term follow up and quality of life data in Asian patients Reviewed

Shiro Tanaka, Sachiko Tanaka, Hirohito Sone

JOURNAL OF DIABETES INVESTIGATION 5 ( 3 ) 281 - 283 2014.5

Meta-Analysis of the Quantitative Relation Between Pulse Pressure and Mean Arterial Pressure and Cardiovascular Risk in Patients With Diabetes Mellitus Reviewed

Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Sakiko Yoshizawa, Yoko Yachi, Shiro Tanaka, Nobumasa Ohara, Satoshi Matsunaga, Takaho Yamada, Osamu Hanyu, Hirohito Sone

AMERICAN JOURNAL OF CARDIOLOGY 113 ( 6 ) 1058 - 1065 2014.3

Quantitative relationship between body weight gain in adulthood and incident type 2 diabetes: a meta-analysis Reviewed

S. Kodama, C. Horikawa, K. Fujihara, S. Yoshizawa, Y. Yachi, S. Tanaka, N. Ohara, S. Matsunaga, T. Yamada, O. Hanyu, H. Sone

OBESITY REVIEWS 15 ( 3 ) 202 - 214 2014.3

Dietary intake in Japanese patients with type 2 diabetes: Analysis from Japan Diabetes Complications Study Reviewed

Chika Horikawa, Yukio Yoshimura, Chiemi Kamada, Shiro Tanaka, Sachiko Tanaka, Akane Takahashi, Osamu Hanyu, Atsushi Araki, Hideki Ito, Akira Tanaka, Yasuo Ohashi, Yasuo Akanuma, Nobuhiro Yamada, Hirohito Sone

JOURNAL OF DIABETES INVESTIGATION 5 ( 2 ) 176 - 187 2014.3

Efficacy of Habitual Exercise for Improving Lipid Profiles Depends on the PPRA gamma Genotype in Japanese Males Reviewed

Yasuko Sone, Reiko Hirasawa, Ikuyo Ichi, Tomoko Isbikawa, Satoru Kodama, Hirohito Sone, Shigenobu Egawa, Kazuo Kawahara, Yuzuru Otsuka, Yoko Fujiwara

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 60 ( 1 ) 66 - 70 2014.2

Hypertension increases urinary excretion of immunoglobulin G, ceruloplasmin and transferrin in normoalbuminuric patients with type 2 diabetes mellitus Reviewed

Nobumasa Ohara, Osamu Hanyu, Satoshi Hirayama, Osamu Nakagawa, Yoshifusa Aizawa, Seiki Ito, Hirohito Sone

JOURNAL OF HYPERTENSION 32 ( 2 ) 432 - 438 2014.2

Manifestations of Fulminant CD8 T-cell Post-transplant Lymphoproliferative Disorder Following the Administration of Rituximab for Lymphadenopathy with a High Level of Epstein-Barr Virus (EBV) Replication after Allogeneic Hematopoietic Stem Cell Transplantation Reviewed

Tomoyuki Tanaka, Jun Takizawa, Shukuko Miyakoshi, Takashi Kozakai, Kyoko Fuse, Yasuhiko Shibasaki, Masato Moriyama, Koichi Ohshima, Ken Toba, Tatsuo Furukawa, Hirohito Sone, Masayoshi Masuko

INTERNAL MEDICINE 53 ( 18 ) 2115 - 2119 2014

Relationship between a Low Ankle Brachial Index and All-Cause Death and Cardiovascular Events in Subjects with and without Diabetes Reviewed

Hiroki Yokoyama, Hirohito Sone, Jun Honjo, Shinichiro Okizaki, Daishiro Yamada, Ryushi Shudo, Hitoshi Shimizu, Tatsumi Moriya, Masakazu Haneda

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 21 ( 6 ) 574 - 581 2014

Weight Loss Maintenance for 2 Years after a 6-Month Randomised Controlled Trial Comparing Education-Only and Group-Based Support in Japanese Adults Reviewed

Yoshio Nakata, Masafumi Okada, Koichi Hashimoto, Yoshinori Harada, Hirohito Sone, Kiyoji Tanaka

OBESITY FACTS 7 ( 6 ) 376 - 387 2014

Comparison of the Framingham Risk Score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and Maximum Carotid Intima-Media Thickness for Predicting Coronary Artery Stenosis in Patients with Asymptomatic Type 2 Diabetes Reviewed

Kazuya Fujihara, Hiroaki Suzuki, Akira Sato, Tomoko Ishizu, Satoru Kodama, Yoriko Heianza, Kazumi Saito, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Naoya Yahagi, Hirohito Sone, Hitoshi Shimano

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 21 ( 8 ) 799 - 815 2014

Comparison of different aspects of BMI history to identify undiagnosed diabetes in Japanese men and women: Toranomon hospital health management center study 12 (TOPICS 12) Reviewed

S. Yoshizawa, Y. Heianza, Y. Arase, K. Saito, S. D. Hsieh, H. Tsuji, O. Hanyu, A. Suzuki, S. Tanaka, S. Kodama, H. Shimano, S. Hara, H. Sone

Diabetic Medicine 31 ( 11 ) 1378 - 1386 2014

Utility of the Triglyceride Level for Predicting Incident Diabetes Mellitus According to the Fasting Status and Body Mass Index Category: The Ibaraki Prefectural Health Study Reviewed

Kazuya Fujihara, Ayumi Sugawara, Yoriko Heianza, Toshimi Sairenchi, Fujiko Irie, Hiroyasu Iso, Mikio Doi, Hitoshi Shimano, Hiroshi Watanabe, Hirohito Sone, Hitoshi Ota

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 21 ( 11 ) 1152 - 1169 2014

Association of Helicobacter pylori Infection with Glycemic Control in Patients with Diabetes: A Meta-Analysis Reviewed

Chika Horikawa, Satoru Kodama, Kazuya Fujihara, Yoko Yachi, Shiro Tanaka, Akiko Suzuki, Osamu Hanyu, Hitoshi Shimano, Hirohito Sone

JOURNAL OF DIABETES RESEARCH 2014 250620 2014

Reversible brain atrophy and cognitive impairment in an adolescent Japanese patient with primary adrenal Cushing's syndrome. Reviewed International journal

Nobumasa Ohara, Hiroshi Suzuki, Akiko Suzuki, Masanori Kaneko, Masahiro Ishizawa, Kazuo Furukawa, Takahiro Abe, Yasuhiro Matsubayashi, Takaho Yamada, Osamu Hanyu, Takayoshi Shimohata, Hirohito Sone

Neuropsychiatric disease and treatment 10 1763 - 7 2014

Early Diagnosis of Hepatic Intravascular Lymphoma: A Case Report and Literature Review Reviewed

Hiroyuki Abe, Kenya Kamimura, Maiko Mamizu, Yasuhiko Shibazaki, Takanobu Ishiguro, Shin-ichi Katada, Yu-ki Nishiyama, Yoshifumi Takahashi, Yu-ya Hatano, Ken-ichi Mizuno, Yukari Watanabe, Aiko Nagashima, Jun Takizawa, Manabu Takeuchi, Hirokazu Kawai, Minoru Nomoto, Hirohito Sone, Masatoyo Nishizawa, Yutaka Aoyagi

INTERNAL MEDICINE 53 ( 6 ) 587 - 593 2014

Primary fibroblast cultures and karyotype analysis for the olive ridley sea turtle (Lepidochelys olivacea)

Tomokazu Fukuda, Masafumi Katayama, Kodzue Kinoshita, Takashi Kasugai, Hitoshi Okamoto, Kiyoshige Kobayashi, Masanori Kurita, Makoto Soichi, Kenichiro Donai, Takafumi Uchida, Manabu Onuma, Hideko Sone, Emiko Isogai, Miho Inoue-Murayama

In Vitro Cellular and Developmental Biology - Animal 50 ( 5 ) 381 - 383 2014

Food groups and weight gain in Japanese men

Hirohito Sone

Clinical Obesity 2014

Quality and accuracy of Internet information concerning a healthy diet Reviewed

Reiko Hirasawa, Yoko Yachi, Sakiko Yoshizawa, Chika Horikawa, Yoriko Heianza, Ayumi Sugawara, Yasuko Sone, Kazuo Kondo, Hitoshi Shimano, Kazumi Saito, Satoru Kodama, Hirohito Sone

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION 64 ( 8 ) 1007 - 1013 2013.12

Intakes of Dietary Fiber, Vegetables, and Fruits and Incidence of Cardiovascular Disease in Japanese Patients With Type 2 Diabetes Reviewed

Shiro Tanaka, Yukio Yoshimura, Chiemi Kamada, Sachiko Tanaka, Chika Horikawa, Ryota Okumura, Hideki Ito, Yasuo Ohashi, Yasuo Akanuma, Nobuhiro Yamada, Hirohito Sone

DIABETES CARE 36 ( 12 ) 3916 - 3922 2013.12

Effect of postmenopausal status and age at menopause on type 2 diabetes and prediabetes in Japanese individuals: Toranomon Hospital Health Management Center study 17 (TOPICS 17) Reviewed

Yoriko Heianza, Yasuji Arase, Satoru Kodama, Shiun Dong Hsieh, Hiroshi Tsuji, Kazumi Saito, Hitoshi Shimano, Shigeko Hara, Hirohito Sone

Diabetes Care 36 ( 12 ) 4007 - 4014 2013.12

[Stroke in the elderly people with diabetes mellitus]. Reviewed

Minagawa S, Hanyu O, Sone H

Nihon rinsho. Japanese journal of clinical medicine 71 ( 11 ) 1948 - 1953 2013.11

Use of high-normal levels of haemoglobin A(1C) and fasting plasma glucose for diabetes screening and for prediction: a meta-analysis. Reviewed International journal

Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Reiko Hirasawa, Yoko Yachi, Sakiko Yoshizawa, Shiro Tanaka, Yasuko Sone, Hitoshi Shimano, Kaoruko Tada Iida, Kazumi Saito, Hirohito Sone

Diabetes/metabolism research and reviews 29 ( 8 ) 680 - 92 2013.11

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Using high-normal levels of haemoglobin A1C (Abnormal-A1C ) or fasting plasma glucose (FPG) (Abnormal-FPG) for diabetes screening are expected to improve the ability to detect persons with or at high risk of diabetes. We assessed the diagnostic and predictive capacity for diabetes of Abnormal-A1C and Abnormal-FPG. We compared these to the combined use of the two measures to the single use of either measurement. METHODS: We analysed 31 eligible cross-sectional or cohort studies that assessed diagnostic or predictive ability, respectively, by using lower A1C and FPG cutoff values than recommended by current diabetes criteria. Positive and negative likelihood ratios (LR+ and LR-) were calculated to assess the ability to confirm or exclude diabetes, respectively, on the basis of a bivariate random-effects model. RESULTS: With both Abnormal-A1C and Abnormal-FPG, the pooled LR+ was above 4 for diagnosing diabetes and above 3 for predicting diabetes. However, the pooled LR- for predicting diabetes was higher with Abnormal-A1C (0.48) and Abnormal-FPG (0.49) in comparison with that for diagnosing diabetes (0.27, Abnormal-A1C ; 0.28, Abnormal-FPG). In eight studies that assessed the predictive ability of the combination of A1C and FPG, using either Abnormal-A1C or Abnormal-FPG could lower LR- to 0.17 from 0.43 for only Abnormal-A1C and from 0.38 for only Abnormal-FPG. Accordingly, LR+ was also lowered to 2.37 from 3.36 for only Abnormal-A1C and from 3.84 for only-Abnormal-FPG. CONCLUSION: The use of the two blood glucose tests had insufficient capacity to identify subjects at high risk for diabetes but had considerable capacity to identify undiagnosed diabetes.

DOI： 10.1002/dmrr.2445

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Efficacy and safety in sitagliptin therapy for diabetes complicated by non-alcoholic fatty liver disease Reviewed

Yasuji Arase, Yusuke Kawamura, Yuya Seko, Mariko Kobayashi, Fumitaka Suzuki, Yoshiyuki Suzuki, Norio Akuta, Masahiro Kobayashi, Hitomi Sezaki, Satoshi Saito, Tetsuya Hosaka, Kenji Ikeda, Hiromitsu Kumada, Yuki Ohmoto-Sekine, Shiun Dong Hsieh, Kazuhisa Amakawa, Kyoko Ogawa, Naoki Matsumoto, Akiko Iwao, Hiroshi Tsuji, Shigeko Hara, Yasumichi Mori, Minoru Okubo, Hirohito Sone, Tetsuro Kobayashi

HEPATOLOGY RESEARCH 43 ( 11 ) 1163 - 1168 2013.11

Diabetic Cardiomyopathy and Oxidative Stress Reviewed

Somasundaram Arumugam, Vengadeshprabhu Karuppagounder, Rajarajan A. Thandavarayan, Vigneshwaran Pitchaimani, Hirohito Sone, Kenichi Watanabe

Diabetes: Oxidative Stress and Dietary Antioxidants 25 - 32 2013.11

Association of living alone with the presence of undiagnosed diabetes in Japanese men: The role of modifiable risk factors for diabetes: Toranomon hospital health management center study 13 (TOPICS 13) Reviewed

Y. Heianza, Y. Arase, S. Kodama, S. D. Hsieh, H. Tsuji, K. Saito, H. Shimano, S. Hara, H. Sone

Diabetic Medicine 30 ( 11 ) 1355 - 1359 2013.11

[Cutting-edge of medicine; clinical epidemiology regarding clinical and pathophysiological features of Japanese patients with type 2 diabetes mellitus]. Reviewed

Sone H, Akanuma Y, Yamada N

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 102 ( 10 ) 2714 - 2722 2013.10

TFE3 Controls Lipid Metabolism in Adipose Tissue of Male Mice by Suppressing Lipolysis and Thermogenesis Reviewed

Yuri Fujimoto, Yoshimi Nakagawa, Aoi Satoh, Kanako Okuda, Akiko Shingyouchi, Ayano Naka, Takashi Matsuzaka, Hitoshi Iwasaki, Kazuto Kobayashi, Naoya Yahagi, Masako Shimada, Shigeru Yatoh, Hiroaki Suzuki, Satomi Yogosawa, Tetsuro Izumi, Hirohito Sone, Osamu Urayama, Nobuhiro Yamada, Hitoshi Shimano

ENDOCRINOLOGY 154 ( 10 ) 3577 - 3588 2013.10

Association Between Remission of Macroalbuminuria and Preservation of Renal Function in Patients With Type 2 Diabetes With Overt Proteinuria Reviewed

Hiroki Yokoyama, Shin-ichi Araki, Jun Honjo, Shinichiro Okizaki, Daishiro Yamada, Ryushi Shudo, Hitoshi Shimizu, Hirohito Sone, Tatsumi Moriya, Masakazu Haneda

DIABETES CARE 36 ( 10 ) 3227 - 3233 2013.10

Diabetic Retinopathy and Microalbuminuria Can Predict Macroalbuminuria and Renal Function Decline in Japanese Type 2 Diabetic Patients: Japan Diabetes Complications Study Reviewed

Tatsumi Moriya, Shiro Tanaka, Ryo Kawasaki, Yasuo Ohashi, Yasuo Akanuma, Nobuhiro Yamada, Hirohito Sone, Hidetoshi Yamashita, Shigehiro Katayama

DIABETES CARE 36 ( 9 ) 2803 - 2809 2013.9

Body Weight Change and Type 2 Diabetes Reviewed

Satoru Kodama, Chika Horikawa, Sakiko Yoshizawa, Kazuya Fujihara, Yoko Yachi, Shiro Tanaka, Akiko Suzuki, Osamu Hanyu, Hiroaki Yagyu, Hirohito Sone

EPIDEMIOLOGY 24 ( 5 ) 778 - 779 2013.9

Direct effect of dasatinib on proliferation and cytotoxicity of natural killer cells in in vitro study Reviewed

Takayoshi Uchiyama, Naoya Sato, Miwako Narita, Akie Yamahira, Minami Iwabuchi, Tatsuo Furukawa, Hirohito Sone, Masuhiro Takahashi

HEMATOLOGICAL ONCOLOGY 31 ( 3 ) 156 - 163 2013.9

Molecular understanding of curcumin in diabetic nephropathy Reviewed

Vivian Soetikno, Kenji Suzuki, Punniyakoti T. Veeraveedu, Somasundaram Arumugam, Arun P. Lakshmanan, Hirohito Sone, Kenichi Watanabe

Drug Discovery Today 18 ( 15-16 ) 756 - 763 2013.8

Genetic Variants of the Fatty Acid Desaturase Gene Cluster Are Associated with Plasma LDL Cholesterol Levels in Japanese Males Reviewed

Yasuko Sone, Toshimi Kido, Tomomi Ainuki, Mariko Sonoda, Ikuyo Ichi, Satoru Kodama, Hirohito Sone, Kazuo Kondo, Yutaka Morita, Shigenobu Egawa, Kazuo Kawahara, Yuzuru Otsuka, Yoko Fujiwara

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 59 ( 4 ) 325 - 335 2013.8

Importance of high-density lipoprotein cholesterol control during pravastatin treatment in hypercholesterolemic Japanese with type 2 diabetes mellitus: A post hoc analysis of MEGA study Reviewed

Rimei Nishimura, Hirohito Sone, Tomoko Nakagami, Naoko Tajima

DIABETES RESEARCH AND CLINICAL PRACTICE 100 ( 2 ) E31 - E33 2013.5

Predicting Macro- and Microvascular Complications in Type 2 Diabetes Reviewed

Shiro Tanaka, Sachiko Tanaka, Satoshi Iimuro, Hidetoshi Yamashita, Shigehiro Katayama, Yasuo Akanuma, Nobuhiro Yamada, Atsushi Araki, Hideki Ito, Hirohito Sone, Yasuo Ohashi

DIABETES CARE 36 ( 5 ) 1193 - 1199 2013.5

Leisure-time physical activity is a significant predictor of stroke and total mortality in Japanese patients with type 2 diabetes: Analysis from the Japan Diabetes Complications Study (JDCS) Reviewed

H. Sone, S. Tanaka, S. Tanaka, S. Suzuki, H. Seino, O. Hanyu, A. Sato, T. Toyonaga, K. Okita, S. Ishibashi, S. Kodama, Y. Akanuma, N. Yamada

Diabetologia 56 ( 5 ) 1021 - 1030 2013.5

Two authors reply Reviewed

Satoru Kodama, Hirohito Sone

American Journal of Epidemiology 177 ( 8 ) 863 2013.4

[Effect of smoking on diabetes mellitus and dyslipidemia (effect of smoking on glucose and lipid metabolism)]. Reviewed

Saito K, Sone H

Nihon rinsho. Japanese journal of clinical medicine 71 ( 3 ) 443 - 448 2013.3

Comparison of Education-Only versus Group-Based Intervention in Promoting Weight Loss: A Randomised Controlled Trial (vol 4, pg 222, 2011)

Nakata, Yoshio, Okada, Masafumi, Hashimoto, Koichi, Harada, Yoshinori, Sone, Hirohito, Tanaka, Kiyoji

OBESITY FACTS 6 ( 1 ) 89 - 90 2013.3

Development of a Screening Score for Undiagnosed Diabetes and Its Application in Estimating Absolute Risk of Future Type 2 Diabetes in Japan: Toranomon Hospital Health Management Center Study 10 (TOPICS 10) Reviewed

Yoriko Heianza, Yasuji Arase, Kazumi Saito, Shiun Dong Hsieh, Hiroshi Tsuji, Satoru Kodama, Shiro Tanaka, Yasuo Ohashi, Hitoshi Shimano, Nobuhiro Yamada, Shigeko Hara, Hirohito Sone

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 98 ( 3 ) 1051 - 1060 2013.3

Fruit Intake and Incident Diabetic Retinopathy with Type 2 Diabetes Reviewed

Shiro Tanaka, Yukio Yoshimura, Ryo Kawasaki, Chiemi Kamada, Sachiko Tanaka, Chika Horikawa, Yasuo Ohashi, Atsushi Araki, Hideki Ito, Yasuo Akanuma, Nobuhiro Yamada, Hidetoshi Yamashita, Hirohito Sone

EPIDEMIOLOGY 24 ( 2 ) 204 - 211 2013.3

Role of alcohol drinking pattern in type 2 diabetes in Japanese men: the Toranomon Hospital Health Management Center Study 11 (TOPICS 11) Reviewed

Yoriko Heianza, Yasuji Arase, Kazumi Saito, Hiroshi Tsuji, Kazuya Fujihara, Shiun Dong Hsieh, Satoru Kodama, Hitoshi Shimano, Nobuhiro Yamada, Shigeko Hara, Hirohito Sone

AMERICAN JOURNAL OF CLINICAL NUTRITION 97 ( 3 ) 561 - 568 2013.3

Risk of Cardiovascular Diseases Is Increased Even with Mild Diabetic Retinopathy The Japan Diabetes Complications Study Reviewed

Ryo Kawasaki, Shiro Tanaka, Sachiko Tanaka, Sachi Abe, Hirohito Sone, Koutaro Yokote, Shun Ishibashi, Shigehiro Katayama, Yasuo Ohashi, Yasuo Akanuma, Nobuhiro Yamada, Hidetoshi Yamashita

OPHTHALMOLOGY 120 ( 3 ) 574 - 582 2013.3

The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic-non-obese type 2 diabetic rats: A differential role of unfolded protein response (UPR) signaling proteins Reviewed

Arun Prasath Lakshmanan, Meilei Harima, Kenji Suzuki, Vivian Soetikno, Masaki Nagata, Takashi Nakamura, Toshihiro Takahashi, Hirohito Sone, Hiroshi Kawachi, Kenichi Watanabe

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 45 ( 2 ) 438 - 447 2013.2

Association Between Physical Activity and Risk of All-Cause Mortality and Cardiovascular Disease in Patients With Diabetes A meta-analysis Reviewed

Satoru Kodama, Shiro Tanaka, Yoriko Heianza, Kazuya Fujihara, Chika Horikawa, Hitoshi Shimano, Kazumi Saito, Nobuhiro Yamada, Yasuo Ohashi, Hirohito Sone

DIABETES CARE 36 ( 2 ) 471 - 479 2013.2

Metabolic predictors of ischemic heart disease and cerebrovascular attack in elderly diabetic individuals: Difference in risk by age Reviewed

Toshio Hayashi, Atsushi Araki, Seinosuke Kawashima, Hirohito Sone, Hiroshi Watanabe, Takashi Ohrui, Koutaro Yokote, Minoru Takemoto, Kiyoshi Kubota, Mitsuhiko Noda, Hiroshi Noto, Koichiro Ina, Hideki Nomura

Cardiovascular Diabetology 12 ( 1 ) 10 2013.1

Diabetes and Risk of Hearing Impairment in Adults: A Meta-Analysis Reviewed

Chika Horikawa, Satoru Kodama, Shiro Tanaka, Kazuya Fujihara, Reiko Hirasawa, Yoko Yachi, Hitoshi Shimano, Nobuhiro Yamada, Kazumi Saito, Hirohito Sone

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 98 ( 1 ) 51 - 58 2013.1

Nutrition education in Japanese medical schools: A follow-up survey Reviewed

Hideo Orimo, Takahiro Ueno, Hiroshi Yoshida, Hirohito Sone, Akira Tanaka, Hiroshige Itakura

Asia Pacific Journal of Clinical Nutrition 22 ( 1 ) 144 - 149 2013.1

TFE3 inhibits myoblast differentiation in C2C12 cells via down-regulating gene expression of myogenin Reviewed

Ayano Naka, Kaoruko Tada Iida, Yoshimi Nakagawa, Hitoshi Iwasaki, Yoshinori Takeuchi, Aoi Satoh, Takashi Matsuzaka, Kiyo-aki Ishii, Kazuto Kobayashi, Shigeru Yatoh, Masako Shimada, Naoya Yahagi, Hiroaki Suzuki, Hirohito Sone, Nobuhiro Yamada, Hitoshi Shimano

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 430 ( 2 ) 664 - 669 2013.1

Low BMI at age 20years predicts gestational diabetes independent of BMI in early pregnancy in Japan: Tanaka Women's Clinic Study Reviewed

Y. Yachi, Y. Tanaka, I. Nishibata, A. Sugawara, S. Kodama, K. Saito, H. Sone

Diabetic Medicine 30 ( 1 ) 70 - 73 2013.1

The Relationship between Diabetic Neuropathy and Sleep Apnea Syndrome: A Meta-Analysis. Reviewed International journal

Kazuya Fujihara, Satoru Kodama, Chika Horikawa, Sakiko Yoshizawa, Ayumi Sugawara, Reiko Hirasawa, Hitoshi Shimano, Yoko Yachi, Akiko Suzuki, Osamu Hanyu, Hirohito Sone

Sleep disorders 2013 150371 - 150371 2013

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

Aims. High prevalence of sleep apnea syndrome (SAS) has been reported in patients with diabetes. However, whether diabetic neuropathy (DN) contributes to this high prevalence is controversial. Our aim of this study is to compare the prevalence of SAS between patients with and without DN. Methods. Systematic literature searches were conducted for cross-sectional studies that reported the number of patients with DN and SAS using MEDLINE (from 1966 to Nov 5, 2012) and EMBASE (from 1974 to Nov 5, 2012). Odds ratios (ORs) of SAS related to DN were pooled with the Mantel-Haenszel method. Results. Data were obtained from 5 eligible studies (including 6 data sets, 880 participants, and 429 cases). Overall, the pooled OR of SAS in patients with DN compared with that in non-DN patients was significant (OR (95% CI), -1.95 (1.03-3.70)). The pooled OR of SAS was 1.90 (0.97-3.71) in patients with type 2 diabetes. Excluding data on patients with type 1 diabetes, a higher OR was observed in younger patients (mean age <60 years) than in those ≥60 years among whom the OR remained significant (3.82; 95% CI, 2.24-6.51 and 1.17; 95% CI, 0.81-1.68). Conclusions. Current meta-analysis suggested the association of some elements of neuropathy with SAS in type 2 diabetes. Further investigations are needed to clarify whether the association is also true for patients with type 1 diabetes.

DOI： 10.1155/2013/150371

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Carotid artery plaque and LDL-to-HDL cholesterol ratio predict atherosclerotic status in coronary arteries in asymptomatic patients with type 2 diabetes mellitus Reviewed

Kazuya Fujihara, Hiroaki Suzuki, Akira Sato, Satoru Kodama, Yoriko Heianza, Kazumi Saito, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Nobuhiro Yamada, Hirohito Sone, Hitoshi Shimano

Journal of Atherosclerosis and Thrombosis 20 ( 5 ) 452 - 464 2013

Various Components of Blood Pressure as Stroke Risk in Japanese Patients With Type 2 Diabetes: Analysis from the Japan Diabetes Complications Study (JDCS)

Hirohito Sone

Diabetes 2013

Combined Risk of Alcohol Intake and Smoking for Development of Type 2 Diabetes in the General Population in Japan: The Ibaraki Prefectural Health Study

Hirohito Sone

Diabetes 2013

Effects of Recommendation Notices for Clinic Visits by Nationwide Health Screening System in Japan

Hirohito Sone

Diabetes 2013

Elovl6 Promotes Nonalcoholic Steatohepatitis Reviewed

Takashi Matsuzaka, Ayaka Atsumi, Rie Matsumori, Tang Nie, Haruna Shinozaki, Noriko Suzuki-Kemuriyama, Motoko Kuba, Yoshimi Nakagawa, Kiyoaki Ishii, Masako Shimada, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Kazuhiro Takekoshi, Hirohito Sone, Naoya Yahagi, Hiroaki Suzuki, Soichiro Murata, Makoto Nakamuta, Nobuhiro Yamada, Hitoshi Shimano

HEPATOLOGY 56 ( 6 ) 2199 - 2208 2012.12

Development of a new scoring system for predicting the 5 year incidence of type 2 diabetes in Japan: the Toranomon Hospital Health Management Center Study 6 (TOPICS 6) Reviewed

Y. Heianza, Y. Arase, S. D. Hsieh, K. Saito, H. Tsuji, S. Kodama, S. Tanaka, Y. Ohashi, H. Shimano, N. Yamada, S. Hara, H. Sone

Diabetologia 55 ( 12 ) 3213 - 3223 2012.12

Enhancement of antigen presenting ability in the leukemic plasmacytoid dendritic cell line (PMDC05) by lentiviral vector-mediated transduction of CD80 gene Reviewed

Akie Yamahira, Miwako Narita, Kayoko Ishii, R. M. Chamila Jayathilake, Minami Iwabuchi, Naoya Satoh, Takayoshi Uchiyama, Tomoyo Taniguchi, Shigeo Hashimoto, Noriyuki Kasahara, Emmanuelle Faure, Brooke Bogan, Jun Takizawa, Hirohito Sone, Masuhiro Takahashi

LEUKEMIA RESEARCH 36 ( 12 ) 1541 - 1546 2012.12

Cholesterol sulfate induces expression of the skin barrier protein filaggrin in normal human epidermal keratinocytes through induction of ROR alpha Reviewed

Osamu Hanyu, Hanako Nakae, Takashi Miida, Yuko Higashi, Hirotoshi Fuda, Motohiro Endo, Atsushi Kohjitani, Hirohito Sone, Charles A. Strott

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 428 ( 1 ) 99 - 104 2012.11

Self-reported rate of eating is significantly associated with body mass index in Japanese patients with type 2 diabetes. Japan Diabetes Clinical Data Management Study Group (JDDM26) Reviewed

Aki Saito, Koichi Kawai, Morifumi Yanagisawa, Hiroki Yokoyama, Nobuichi Kuribayashi, Hidekatsu Sugimoto, Mariko Oishi, Takako Wada, Koichi Iwasaki, Azuma Kanatsuka, Noriharu Yagi, Fuminobu Okuguchi, Kazuhiro Miyazawa, Keiko Arai, Kazumi Saito, Hirohito Sone

APPETITE 59 ( 2 ) 252 - 255 2012.10

Development of Coronary Heart Disease and Cerebral Stroke in Japanese Elderly Patients with Nonalcoholic Fatty Liver Diseases

OGAWA Kyoko, OHMONTO SEKINE Yuki, HARA Shigeko, OKUDA Chikao, AMAKAWA Kazuhisa, ARIMOTO Satao, KATO Hisahito, HSIEH Shiun Dong, TANABE Maho, OGATA Chie, ISHIHARA Makiko, TSUJI Hiroshi, SAITO Kazumi, KODAMA Satoru, SONE Hirohito, ARASE Yasuji

Official Journal of the Japanese Society of Human Dry Dock 27 ( 3 ) 561 - 567 2012.9

Language：English Publisher：Japan Society of Ningen Dock

Objective: Metabolic syndrome enhances coronary heart disease and cerebral stroke. However, few longitudinal studies have been conducted on the incidence of coronary heart disease and cerebral stroke in Japanese patients with non-alcoholic fatty liver disease (NAFLD) and the risk factors for its development. Methods: A total of 1,798 NAFLD patients with an age of ≥60 years were enrolled. The primary event was the first onset of coronary heart disease or cerebral stroke. Independent factors associated with the incidence rate of such events were analyzed by the Kaplan-Meyer method and the Cox proportional hazard model. The mean observation period was 7.5 years. Results: The number of cases of coronary heart disease or cerebral stroke that developed was 137. The 10th year cumulative development rate was 11.7% in the NAFLD patients. Cox proportional hazards analysis revealed the following: 1) Coronary heart disease occurred with statistical significance when patients had poor control of blood pressure, smoking, low high density lipoprotein level, and high glucose level. 2) Ischemic stroke occurred with statistical significance when patients had poor control of blood pressure, an age of ≥70 years, and high glucose level. 3) Hemorrhagic stroke occurred with statistical significance when patients had poor control of blood pressure, age ≥70 years, low albumin level of <3.9 g/dL and high aspartate aminotransferase to platelet ratio index. Conclusion: Our study indicates that the risk factors for the development of vascular disease are different for coronary heart disease, ischemic stroke and hemorrhagic stroke in Japanese elderly patients with NAFLD.

DOI： 10.11320/ningendock.27.561

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Screening for pre-diabetes to predict future diabetes using various cut-off points for HbA1c and impaired fasting glucose: the Toranomon Hospital Health Management Center Study 4 (TOPICS 4)

Y. Heianza, Y. Arase, K. Fujihara, H. Tsuji, K. Saito, S. D. Hsieh, S. Kodama, H. Shimano, N. Yamada, S. Hara, H. Sone

DIABETIC MEDICINE 29 ( 9 ) E279 - E285 2012.9

Low Lung Function and Risk of Type 2 Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study 9 (TOPICS 9) Reviewed

Yoriko Heianza, Yasuji Arase, Hiroshi Tsuji, Kazumi Saito, Kazuhisa Amakawa, Shiun Dong Hsieh, Satoru Kodama, Hitoshi Shimano, Nobuhiro Yamada, Shigeko Hara, Hirohito Sone

MAYO CLINIC PROCEEDINGS 87 ( 9 ) 853 - 861 2012.9

HbA(1c) variability and the development of microalbuminuria in type 2 diabetes: Tsukuba Kawai Diabetes Registry 2 Reviewed

A. Sugawara, K. Kawai, S. Motohashi, K. Saito, S. Kodama, Y. Yachi, R. Hirasawa, H. Shimano, K. Yamazaki, H. Sone

DIABETOLOGIA 55 ( 8 ) 2128 - 2131 2012.8

[Characteristics of diabetic macroangiopathy in Japan and East Asia]. Reviewed

Sone H

Nihon rinsho. Japanese journal of clinical medicine 70 Suppl 5 305 - 312 2012.7

Present situation of exercise therapy for patients with diabetes mellitus in Japan: A nationwide survey Reviewed

Y. Sato, K. Kondo, T. Watanabe, H. Sone, M. Kobayashi, R. Kawamori, Y. Tamura, Y. Atsumi, Y. Oshida, S. Tanaka, S. Suzuki, S. Makita, I. Ohsawa, S. Imamura

Diabetology International 3 ( 2 ) 86 - 91 2012.6

[New vision of secondary and tertiary prevention in diabetic complication]. Reviewed

Fujihara K, Sone H

Nihon rinsho. Japanese journal of clinical medicine 70 Suppl 3 561 - 569 2012.5

[Japan Diabetes Complications Study (JDCS)]. Reviewed

Sone H, Katayama S, Yamashita H, Akanuma Y, Yamada N

Nihon rinsho. Japanese journal of clinical medicine 70 Suppl 3 281 - 289 2012.5

Quantification of BCR-ABL mRNA in Plasma/Serum of Patients with Chronic Myelogenous Leukemia Reviewed

Miwako Narita, Anri Saito, Aya Kojima, Minami Iwabuchi, Naoya Satoh, Takayoshi Uchiyama, Akie Yamahira, Tatsuo Furukawa, Hirohito Sone, Masuhiro Takahashi

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 9 ( 10 ) 901 - 908 2012

Impact of psychological stress caused by the Great East Japan Earthquake on glycemic control in patients with diabetes Reviewed

K. Fujihara, A. Saito, Y. Heianza, H. Gibo, H. Suzuki, H. Shimano, K. Saito, S. Kodama, N. Yamada, H. Sone

Experimental and Clinical Endocrinology and Diabetes 120 ( 9 ) 560 - 563 2012

Diagnosis and Management of Type I and Type V Hyperlipoproteinemia Reviewed

Takanari Gotoda, Koji Shirai, Takao Ohta, Junji Kobayashi, Shinji Yokoyama, Shinichi Oikawa, Hideaki Bujo, Shun Ishibashi, Hidenori Arai, Shizuya Yamashita, Mariko Harada-Shiba, Masaaki Eto, Toshio Hayashi, Hirohito Sone, Hiroaki Suzuki, Nobuhiro Yamada

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 19 ( 1 ) 1 - 12 2012

Idiopathic Macrocytosis in Smokers

Takahashi Masuhiro, Yamahira Akie, Uchiyama Takayoshi, Iwabuchi Minami, Sato Naoya, Takizawa Jun, Sone Hirohito, Narita Miwako

Official Journal of the Japanese Society of Human Dry Dock 27 ( 4 ) 689 - 696 2012

Language：Japanese Publisher：Japan Society of Ningen Dock

Objective: Smoking has been reported to be one of the risk factors of myelodysplastic syndrome (MDS). In order to clarify the process of progression to MDS in a certain group of smokers, it is important to identify the initial hematological abnormalities associated with the early stage of MDS in smokers. Methods: Relationships of hematological parameters such as WBC count, RBC count, Hb, Ht, MCH and MCV with level of smoking were investigated by univariate and multivariate analyses in 234 male workers at a single workplace after obtaining informed consent. Results: Univariate analysis demonstrated that correlations of smoking-related factors (number of cigarettes per day, duration of smoking [years] and smoking index [defined as number of cigarettes per day x duration of smoking]) with WBC count, Ht, MCH and MCV were significantly positive. Multivariate analysis using age, smoking-related factors, alcohol intake and BMI as explanatory valuables showed that age, alcohol intake and BMI were not confounding variables for smoking-related factors and revealed a remarkable significant positive correlation between each smoking-related factor and MCV. Conclusion: Smoking-associated macrocytosis, which was demonstrated in the present study, was not due to deficiency of vitamin B12 or folic acid because of no pancytopenia observed but was considered to be a qualitative abnormality of erythrocytes. Taken together with the findings of previous studies concerning smoking-associated functional abnormalities of erythrocytes and leukocytes and the high incidence of MDS in smokers, our results indicate that idiopathic macrocytosis in smokers could be an initial sign of progression to MDS, in which macrocytosis and multi-lineage abnormalities are characteristic findings.

DOI： 10.11320/ningendock.27.689

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Determining Optimal Combined Thresholds of HbA1c and Fasting Plasma Glucose as Predictors of Type 2 Diabetes: The Toranomon Hospital Health Management Center Study

Hirohito Sone

Diabetes 2012

Low Lung Function and Risk of Type 2 Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study

Hirohito Sone

Diabetes 2012

Erratum: Accumulation of cardiovascular risks in Japanese women with abnormal glucose and mild to moderate hypercholesterolemia (International Journal of Cardiology (2011) 152,2 (254-256)) Reviewed

Tomoko Nakagami, Rimei Nishimura, Hirohito Sone, Naoko Tajima

International Journal of Cardiology 153 ( 2 ) 238 2011.12

SiRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells

Xian-Yang Qin, Feifei Wei, Jun Yoshinaga, Junzo Yonemoto, Masaru Tanokura, Hideko Sone

FEBS Letters 585 ( 20 ) 3310 - 3315 2011.10

Xenoestrogens down-regulate aryl-hydrocarbon receptor nuclear translocator 2 mRNA expression in human breast cancer cells via an estrogen receptor alpha-dependent mechanism.

Qin XY, Zaha H, Nagano R, Yoshinaga J, Yonemoto J, Sone H

2011.10

Accumulation of cardiovascular risks in Japanese women with abnormal glucose and mild to moderate hypercholesterolemia Reviewed

Tomoko Nakagami, Rimei Nishimura, Hirohito Sone, Naoko Tajima

INTERNATIONAL JOURNAL OF CARDIOLOGY 152 ( 2 ) 254 - 256 2011.10

Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells. International journal

Katsuya Dezaki, Boldbaatar Damdindorj, Hideyuki Sone, Oleg Dyachok, Anders Tengholm, Erik Gylfe, Tomoyuki Kurashina, Masashi Yoshida, Masafumi Kakei, Toshihiko Yada

Diabetes 60 ( 9 ) 2315 - 24 2011.9

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Ghrelin reportedly restricts insulin release in islet β-cells via the Gα(i2) subtype of G-proteins and thereby regulates glucose homeostasis. This study explored whether ghrelin regulates cAMP signaling and whether this regulation induces insulinostatic cascade in islet β-cells. RESEARCH DESIGN AND METHODS: Insulin release was measured in rat perfused pancreas and isolated islets and cAMP production in isolated islets. Cytosolic cAMP concentrations ([cAMP](i)) were monitored in mouse MIN6 cells using evanescent-wave fluorescence imaging. In rat single β-cells, cytosolic protein kinase-A activity ([PKA](i)) and Ca(2+) concentration ([Ca(2+)](i)) were measured by DR-II and fura-2 microfluorometry, respectively, and whole cell currents by patch-clamp technique. RESULTS: Ghrelin suppressed glucose (8.3 mmol/L)-induced insulin release in rat perfused pancreas and isolated islets, and these effects of ghrelin were blunted in the presence of cAMP analogs or adenylate cyclase inhibitor. Glucose-induced cAMP production in isolated islets was attenuated by ghrelin and enhanced by ghrelin receptor antagonist and anti-ghrelin antiserum, which counteract endogenous islet-derived ghrelin. Ghrelin inhibited the glucose-induced [cAMP](i) elevation and [PKA](i) activation in MIN6 and rat β-cells, respectively. Furthermore, ghrelin potentiated voltage-dependent K(+) (Kv) channel currents without altering Ca(2+) channel currents and attenuated glucose-induced [Ca(2+)](i) increases in rat β-cells in a PKA-dependent manner. CONCLUSIONS: Ghrelin directly interacts with islet β-cells to attenuate glucose-induced cAMP production and PKA activation, which lead to activation of Kv channels and suppression of glucose-induced [Ca(2+)](i) increase and insulin release.

DOI： 10.2337/db11-0368

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Factors associated with inappropriate weight loss attempts by early adolescent girls in Japan Reviewed

A. Sugawara, M. Sato, K. Totsuka, K. Saito, S. Kodama, A. Fukushi, Y. Yamanashi, E. Matsushima, Y. Fujiwara, E. Suzuki, K. Kondo, S. Yamamoto, H. Sone

Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity 16 ( 3 ) e157 - e163 2011.9

AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats. International journal

Daisuke Kohno, Hideyuki Sone, Shigeyasu Tanaka, Hideharu Kurita, Darambazar Gantulga, Toshihiko Yada

Neuroscience letters 499 ( 3 ) 194 - 8 2011.7

Language：English Publishing type：Research paper (scientific journal)

AMP-activated protein kinase (AMPK) is an energy sensor that is activated by the increase of intracellular AMP:ATP ratio. AMPK in the hypothalamic arcuate nucleus (ARC) is activated during fasting and the activation of AMPK stimulates food intake. To clarify the pathway underlying AMPK-induced feeding, we monitored the activity of single ARC neurons by measuring cytosolic Ca(2+) concentration ([Ca(2+)](i)) with fura-2 fluorescence imaging. An AMPK activator, AICA-riboside (AICAR), at 200 μM increased [Ca(2+)](i) in 24% of ARC neurons. AMPK and acetyl CoA carboxylase were phosphorylated in the neurons with [Ca(2+)](i) responses to AICAR. AICAR-induced [Ca(2+)](i) increases were inhibited by Ca(2+)-free condition but not by thapsigargin, suggesting that AICAR increases [Ca(2+)](i) through Ca(2+) influx from extracellular space. Among AICAR-responding ARC neurons, 38% were neuropeptide Y (NPY)-immunoreactive neurons while no proopiomelanocortin (POMC)-immunoreactive neuron was observed. Intracerebroventricular administration of AICAR increased food intake, and the AICAR-induced food intake was abolished by the co-administration of NPY Y1 receptor antagonist, 1229U91. These results indicate that the activation of AMPK leads to the activation of ARC NPY neurons through Ca(2+) influx, thereby causing NPY-dependent food intake. These mechanisms could be implicated in the stimulation of food intake by physiological orexigenic substances.

DOI： 10.1016/j.neulet.2011.05.060

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Weight History as a Screening Tool for Identifying Undiagnosed Diabetes and Pre-Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study (TOPICS) Reviewed

Sakiko Yoshizawa, Yoriko Heianza, Kazuya Fujiwara, Shigeko Hara, Kazumi Saito, Hiroshi Tsuji, Satoru Kodama, Yasuji Arase, Nobuhiro Yamada, Kinori Kosaka, Hirohito Sone

DIABETES 60 A235 - A235 2011.7

Weight History as a Screening Tool for Identifying Undiagnosed Diabetes and Pre-Diabetes in Japanese Men: The Toranomon Hospital Health Management Center Study (TOPICS) Reviewed

Sakiko Yoshizawa, Yoriko Heianza, Kazuya Fujiwara, Shigeko Hara, Kazumi Saito, Hiroshi Tsuji, Satoru Kodama, Yasuji Arase, Nobuhiro Yamada, Kinori Kosaka, Hirohito Sone

DIABETES 60 A235 - A235 2011.7

Nifedipine, a calcium-channel blocker, attenuated glucose intolerance and white adipose tissue dysfunction in type 2 diabetic KK-A y Mice

Masaru Iwai, Harumi Kanno, Shinji Inaba, Izumi Senba, Hisako Sone, Hirotomo Nakaoka, Masatsugu Horiuchi

American Journal of Hypertension 24 ( 2 ) 169 - 174 2011.2

Nanometer resolution stress measurement of the Si gate using illumination-collection-type scanning near-field Raman spectroscopy with a completely metal-inside-coated pyramidal probe.

Hosaka S, Aramomi Y, Sone H, Yin Y, Sato E, Tochigi K

2011.1

[Diabetes mellitus and metabolic syndrome in epidemiological studies]. Reviewed

Sone H

Nihon rinsho. Japanese journal of clinical medicine 69 Suppl 1 93 - 100 2011.1

HbA1c Variability and Risk of Development of Microalbuminuria in Japanese Patients with Type 2 Diabetes: A Pilot Study, Tsukuba Kawai Diabetes Registry 3

Hirohito Sone

Diabetes 2011

Self-Reported Rate of Eating Is Associated with BMI but Not with Glycemic Control Status in Japanese Patients with Type 2 Diabetes

Hirohito Sone

Diabetes 2011

Evaluation of Clinical Predictors of Vulnerable Coronary Plaque Detected by CT Angiography in Asymptomatic Patients with Type 2 Diabetes (T2DM)

Hirohito Sone

Diabetes 2011

[Prevention and management of atherosclerotic complications of diabetes]. Reviewed

Sone H

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 48 ( 3 ) 253 - 256 2011

Flow-Mediated Dilation is Associated with Microalbuminuria Independent of Cardiovascular Risk Factors in Type 2 Diabetes - Interrelations with Arterial Thickness and Stiffness Reviewed

Hiroki Yokoyama, Hirohito Sone, Kazumi Saito, Daishiro Yamada, Jun Honjo, Masakazu Haneda

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 18 ( 9 ) 744 - 752 2011

[Epidemiology of diabetic microangiopathy in Japan--comparison with Western countries]. Reviewed

Sone H

Nihon rinsho. Japanese journal of clinical medicine 68 Suppl 9 13 - 20 2010.11

Comparison between Fasting and Post-Load Glucose Values as a Continuous Risk Factor for Cardiovascular Disease: A Meta-Analysis Reviewed

Satoru Kodama, Chika Horikawa, Yui Anasako, Kazumi Saito, Reiko Hirasawa, Yoko Ibe, Yoko Yachi, Miho Asumi, Hitoshi Shimano, Nobuhiro Yamada, Hirohito Sone

DIABETES 59 ( Suppl ) A298 - A298 2010.6

Body image: International comparisons: From the symposium held at the 15th international congress of dietetics Reviewed

Ayumi Sugawara, Jun Yanagishita, Ayami Sano, Yueching Wong, Duc Son N.T Le, Jeanne B. Martin, Shigeru Yamamoto, Hirohito Sone

Nutrition Today 45 ( 3 ) 113 - 117 2010.5

Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats.

Watanabe-Kamiyama M, Shimizu M, Kamiyama S, Taguchi Y, Sone H, Morimatsu F, Shirakawa H, Furukawa Y, Komai M

2010.1

Oxygenomics in environmental stress

Hirohito Sone

Redox Report 2010

Low HDL Cholesterol Is Associated With the Risk of Stroke in Elderly Diabetic Individuals Changes in the risk for atherosclerotic diseases at various ages Reviewed

Tosmo Hayashi, Seinosuke Kawashima, Hideki Itoh, Nobuhiro Yamada, Hirohito Sone, Hiroshi Watanabe, Yoshiyuki Hattori, Takashi Ohrui, Koutaro Yokote, Hideki Nomura, Hiroyuki Umegaki, Akihisa Iguchi

DIABETES CARE 32 ( 7 ) 1221 - 1223 2009.7

[Progress in clinical care of cardiovascular diseases complicated with diabetes mellitus]. Reviewed

Sone H, Yamada N

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 98 ( 4 ) 794 - 801 2009.4

1) Current Status of Diabetic Vascular Complication in Japan. from the View Point of the Results of Japan Diabetes Complication Study (JDCS)

Sone Hirohito, Akanuma Yasuo, Yamada Nobuhiro

Nihon Naika Gakkai Kaishi 98 84a - 84a 2009

Effect of low-intensity exercise training on glucose and lipid metabolism and cardiorespiratory fitness in the elderly Reviewed

Kodama Satoru, Miao Shu, Kazumi Saito, Haruka Murakami, Tomohiro Okura, Kiyoji Tanaka, Shinya Kuno, Ryuichi Ajisaka, Nobuhiro Yamada, Hirohito Sone

JOURNAL OF AGING AND PHYSICAL ACTIVITY 16 ( Suppl. S ) S111 - S112 2008.7

Effect of different dietary carbohydrate/fat ratios on glucose metabolism in type 2 diabetic patients: A meta-analysis Reviewed

Satoru Kodama, Kazumi Saito, Yoko Yachi, Yoko Ibe, Mihoko Asumi, Miho Maki, Emiko Suzuki, Hitoshi Shimano, Nobuhiro Yamada, Hirohito Sone

DIABETES 57 A470 - A470 2008.6

Factors affecting remission of microalbuminuria in patients with type 2 diabetes: the Tsukuba Kawai Diabetes Registry (TKDR)2 Reviewed

Kazumi Saito, Koichi Kawaii, Satoru Kodama, Shiro Tanaka, Keni Ro Sakamaki, Ayumi Sugawara, Mut-Sumi Sato, Yasuko Sone, Hitoshi Shimano, Yasuo Ohashi, Nobuhiro Yama, Hirohito Sone

DIABETES 57 A211 - A211 2008.6

Importance of lipid levels in elderly diabetic individuals - Baseline characteristics and 1-year - Survey of cardiovascular events Reviewed

Toshio Hayashi, Seinosuke Kawashima, Hideki Itoh, Nobuhiro Yamada, Hirohito Sone, Hiroshi Watanabe, Yoshiyuki Hattori, Takashi Ohrui, Masashi Yoshizumi, Koutaro Yokote, Kiyoshi Kubota, Hideki Nomura, Hiroyuki Umegaki, Akihisa Iguchi

CIRCULATION JOURNAL 72 ( 2 ) 218 - 225 2008.2

[Intervention study for elevating high density lipoprotein cholesterol level]. Reviewed

Kodama S, Sone H

Nihon rinsho. Japanese journal of clinical medicine 65 Suppl 7 264 - 269 2007.7

Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver Reviewed

Takashi Yamamoto, Hitoshi Shimano, Noriyuki Inoue, Yoshimi Nakagawa, Takashi Matsuzaka, Akimitsu Takahashi, Naoya Yahagi, Hirohito Sone, Hiroaki Suzuki, Hideo Toyoshima, Nobuhiro Yamada

JOURNAL OF BIOLOGICAL CHEMISTRY 282 ( 16 ) 11687 - 11695 2007.4

Effect of exercise training on serum high-sensitivity C-reactive protein concentration in healthy middle-aged and elderly subjects

Ryuichi Ajisaka, Takumi Tanabe, Takeshi Otsuki, Haruka Murakami, Seiji Maeda, Kiyoji Tanaka, Hirohito Sone, Shinya Kuno

JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE 56 ( 1 ) 179 - 189 2007.2

[Metabolic syndrome in Japanese patient with diabetes analysis from JDCS]. Reviewed

Sone H, Akanuma Y, Yamada N

Nihon rinsho. Japanese journal of clinical medicine 64 Suppl 9 74 - 83 2006.12

[Long-term intervention studies of diabetic macroangiopathy in Japan and western countries]. Reviewed

Sone H, Yamada N

Nihon rinsho. Japanese journal of clinical medicine 64 ( 11 ) 2021 - 2030 2006.11

Aldo-keto reductase 1 family B7 is the gene induced in response to oxidative stress in the livers of Long-Evans Cinnamon rats

Guang Jia, Ryoya Takahashi, Zhiping Zhang, Yoshiaki Tsuji, Hideko Sone

International Journal of Oncology 29 ( 4 ) 829 - 838 2006.10

Distribution of retinylester-storing stellate cells in the arrowtooth halibut, Atheresthes evermanni

Kiwamu Yoshikawa, Katsuyuki Imai, Takaharu Seki, Nobuyo Higashi-Kuwata, Naosuke Kojima, Mitsuharu Yuuda, Kazuo Koyasu, Hiroshi Sone, Mitsuru Sato, Haruki Senoo, Toshiaki Irie

Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology 145 ( 2 ) 280 - 286 2006.10

Leptin resistance conferred by a combination of single nucleotide polymorphism and the adoption of a western lifestyle in urban areas of Thailand

Hirohito Sone

The Journal of Nutrition, Health & Aging 2006

Leptin resistance conferred by a combination of single nucleotide polymorphism and the adoption of a Western lifestyle in urban areas of Thailand.

Yanagisawa Y, Iwamoto S, Kawabata T, Nakamura Y, Charupoonphol P, Supannatas S, Sone H, Kaneko Y, Watanabe S, Komatsu F, Sakuma M, Miyagi S, Hasegawa K, Kagawa Y

2006

Exercise Training for Ameliorating Cardiovascular Risk Factors-focusing on Exercise Intensity and Amount

Kodama Satoru, Miao Shu, Yamada Nobuhiro, Sone Hirohito

Int. J. Sport Health Sci. 4 325 - 338 2006

Language：English Publisher：Japan Society of Physical Education, Health and Sport Sciences

Exercise training suppresses cardiovascular risk factors by improving lipid/glucose metabolism, insulin resistance and hypertension. There is an optimum amount and intensity of exercise that will suppress each risk factor, although limited information is currently available on this area. For instance, the level of high-density lipoprotein cholesterol seems to be dependent more on the amount than on the intensity of exercise training; the situation with exercise-induced suppression of triglyceride levels is less clear. It is notable that the ability of mild intensity or a low amount of exercise to suppress or prevent cardiovascular risk factors is largely unknown. This knowledge is essential for prescribing safe and effective exercise training to elderly people. At the same time, very few studies on the associations between cardiovascular risk factors in response to exercise can be found. For example, improvement in lipid metabolism or insulin resistance seems to be related to the weight loss seen during exercise training but weight-independent effects could also be observed. The optimal intensity and amount of exercise training for each cardiovascular risk factor and the relationships between the effects of exercise training on each risk factor need to be clarified in the near future in order to establish guidelines that can be applied to the majority of elderly people at risk of cardiovascular diseases.

DOI： 10.5432/ijshs.4.325

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Other Link： http://search.jamas.or.jp/link/ui/2007328852

Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47 Reviewed

M Amemiya-Kudo, J Oka, T Ide, T Matsuzaka, H Sone, T Yoshikawa, N Yahagi, S Ishibashi, J Osuga, N Yamada, T Murase, H Shimano

JOURNAL OF BIOLOGICAL CHEMISTRY 280 ( 41 ) 34577 - 34589 2005.10

Effects of aerobic training on visceral fat and glucose metabolism in older adults

Y Hayashi, K Tanaka, H Sone, S Kuno

JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE 54 ( 4 ) 305 - 313 2005.8

Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes. International journal

Akimitsu Takahashi, Hitoshi Shimano, Yoshimi Nakagawa, Takashi Yamamoto, Kaori Motomura, Takashi Matsuzaka, Hirohito Sone, Hiroaki Suzuki, Hideo Toyoshima, Nobuhiro Yamada

Biochimica et biophysica acta 1740 ( 3 ) 427 - 33 2005.6

Language：English Publishing type：Research paper (scientific journal)

Sterol regulatory element-binding protein-1 (SREBP-1) is a transcription factor which regulates genes involved in the synthesis of fatty acids and triglycerides. The overexpression of nuclear SREBP-1a in transgenic mice under the control of the PEPCK promoter (TgSREBP-1a) caused a massively enlarged fatty liver and disappearance of peripheral white adipose tissue. In the current study, we estimated the impact of this lipid transcription factor on plasma glucose/insulin metabolism in vivo. TgSREBP-1a exhibited mild peripheral insulin resistance as evidenced by hyperinsulinemia both at fasting and after intravenous glucose loading, and retarded glucose reduction after insulin injection due to decreased plasma leptin levels. Intriguingly, hyperinsulinemia in TgSREBP-1a mice was markedly exacerbated in a fed state and sustained after intravenous glucose loading, and paradoxically decreased after the portal injection of glucose. TgSREBP-1a mice consistently showed very small plasma glucose increases after portal glucose loading because of a large capacity for hepatic glucose uptake. These data suggested that hepatic insulin resistance emerges postprandially. In addition, pancreatic islets from TgSREBP-1a were enlarged. These data demonstrate that SREBP-1a activation in the liver has a strong impact on plasma insulin levels, implicating the potential role of SREBPs in hepatic insulin metabolism relating to insulin resistance.

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[Prevalence and incidence of diabetic microangiopathy in Japan]. Reviewed

Sone H, Yamada N, Yamashita H, Katayama S, Akanuma Y

Nihon rinsho. Japanese journal of clinical medicine 63 Suppl 6 18 - 22 2005.6

[Recent trends in diabetic complications in Japan]. Reviewed

Sone H, Saito Y, Yoshimura Y, Ishibashi S, Ito H, Yamashita H, Yamazaki Y, Katayama S, Ohashi Y, Akanuma Y, Yamada N

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 93 ( 11 ) 2427 - 2434 2004.11

効果的な内臓脂肪の減量方法

田中喜代次, 中田由夫, 大蔵倫博, 曽根博仁

文部科学省科学技術振興調整費報告書「地域の中高齢者における生活機能増進法の具体策～体力年齢の若返り法とその地位システム～」 56-57 2004.8

内蔵脂肪に関する最新情報

田中喜代次, 中田由夫, 大蔵倫博, 曽根博仁

文部科学省科学技術振興調整費報告書「地域の中高齢者における生活機能増進法の具体策～体力年齢の若返り法とその地位システム～」 18-19 2004.8

Type 2 diabetes prevalence in Asian subjects: Response to McNeely and Boyko Reviewed

Hirohito Sone, Sachiko Mizuno, Yasushi Ohashi, Nobuhiro Yamada

DIABETES CARE 27 ( 5 ) 1252 - 1252 2004.5

[Vascular dysfunction in metabolic syndrome: 2) Risk for coronary artery disease]. Reviewed

Sone H, Yamada N

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 93 ( 4 ) 670 - 676 2004.4

Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice Reviewed

T Matsuzaka, H Shimano, N Yahagi, M Amemiya-Kudo, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, S Tomita, M Sekiya, A Hasty, Y Nakagawa, H Sone, H Toyoshima, S Ishibashi, J Osuga, N Yamada

DIABETES 53 ( 3 ) 560 - 569 2004.3

内臓脂肪に関する最新情報「地域の中高齢者における．生活機能増進法の具体策～体力年齢の若返り法とその地位システム～」

田中喜代次, 中田由夫, 大藏倫博, 曽根博仁

文部科学省科学技術振興調整費報告書 18-19 2004.1

Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals

Shunichi Terasaka, Yukie Aita, Akio Inoue, Shinichi Hayashi, Michiko Nishigaki, Kazuhiko Aoyagi, Hiroki Sasaki, Yuko Wada-Kiyama, Yasuo Sakuma, Shuichi Akaba, Junko Tanaka, Hideko Sone, Junzo Yonemoto, Masao Tanji, Ryoiti Kiyama

Environmental Health Perspectives 112 ( 7 ) 773 - 781 2004

Gene interaction network suggests dioxin induces a significant linkage between aryl hydrocarbon receptor and retinoic acid receptor beta

Hirohito Sone

Environmental Health Perspectives 2004

Polymorphism, Heteroplasmy, Mitochondrial Fusion and Diabetes

Aya Sato, Hitoshi Endo, Kazuo Umetsu, Hideyuki Sone, Yoshiko Yanagisawa, Azusa Saigusa, Sayuri Aita, Yasuo Kagawa

Bioscience Reports 23 ( 5-6 ) 313 - 337 2003.10

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling Reviewed

T Yoshikawa, T Ide, H Shimano, N Yahagi, M Amemiya-Kudo, T Matsuzaka, S Yatoh, T Kitamine, H Okazaki, Y Tamura, M Sekiya, A Takahashi, AH Hasty, R Sato, H Sone, JI Osuga, S Ishibashi, N Yamada

MOLECULAR ENDOCRINOLOGY 17 ( 7 ) 1240 - 1254 2003.7

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling Reviewed

T Ide, H Shimano, T Yoshikawa, N Yahagi, M Amemiya-Kudo, T Matsuzaka, M Nakakuki, S Yatoh, Y Iizuka, S Tomita, K Ohashi, A Takahashi, H Sone, T Gotoda, JI Osuga, S Ishibashi, N Yamada

MOLECULAR ENDOCRINOLOGY 17 ( 7 ) 1255 - 1267 2003.7

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

Takahiro Fujino, Hiroshi Asaba, Man-Jong Kang, Yukio Ikeda, Hideyuki Sone, Shinji Takada, Dong-Ho Kim, Ryoichi X. Ioka, Masao Ono, Hiroko Tomoyori, Minoru Okubo, Toshio Murase, Akihisa Kamataki, Joji Yamamoto, Kenta Magoori, Sadao Takahashi, Yoshiharu Miyamoto, Hisashi Oishi, Masato Nose, Mitsuyo Okazaki, Shinichi Usui, Katsumi Imaizumi, Masashi Yanagisawa, Juro Sakai, Tokuo T. Yamamoto

Proceedings of the National Academy of Sciences of the United States of America 100 ( 1 ) 229 - 234 2003.1

DNA-adduct formation in lungs, nasal mucosa, and livers of rats exposed to urban roadside air in Kawasaki City, Japan

Hiromi Sato, Kazuo T. Suzuki, Hideko Sone, Yuko Yamano, Jun Kagawa, Yasunobu Aoki

Environmental Research 93 ( 1 ) 36 - 44 2003

The need to integrate diabetes education and treatment - Reply

Hirohito Sone

Hormone and Metabolic Research 2003

[Large-scale randomized intervention trial on diabetes in Japan]. Reviewed

Sone H, Yamada N

Nihon rinsho. Japanese journal of clinical medicine 60 Suppl 10 44 - 50 2002.10

Genetic and physiological analysis of branched-chain alcohols and isoamyl acetate production in Saccharomyces cerevisiae.

Yoshimoto H, Fukushige T, Yonezawa T, Sone H

2002.8

[Recent studies on hyperlipidemia]. Reviewed

Sone H, Yamada N

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 91 ( 4 ) 1202 - 1207 2002.4

Acetyl-coenzyme A Synthetase is a New Lipogenic Enzyme Controlled by Sterol Regulatory Element-binding Protein-1. Reviewed

Sone, H, Shimano, H, Sakakura, Y, Inoue, N, Amemiya-Kudo, M, Takahashi, A, Yokoo, T, Osawa, M, Iwama, A, Yamada, N

Am J Physiol Endocrinol Metab 282 E222-230 2002.1

Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPAR alpha Reviewed

T Matsuzaka, H Shimano, N Yahagi, M Amemiya-Kudo, T Yoshikawa, AH Hasty, Y Tamura, J Osuga, H Okazaki, Y Iizuka, A Takahashi, H Sone, T Gotoda, S Ishibashi, N Yamada

JOURNAL OF LIPID RESEARCH 43 ( 1 ) 107 - 114 2002.1

Genetic and physiological analysis of branched-chain alcohols and isoamyl acetate production in Saccharomyces cerevisiae

Hirohito Sone

Applied Microbiology and Biotechnology 2002

Modal Birefringence dependent supercontinuum due to cross-phase modulation in a dispersion-flattened/decreasing fiber

Hirohito Sone

Optical Review 2002

Influences of polyunsaturated fatty acids and insulin on NO production and ET-1 production in human vascular endothelial cells

Hirohito Sone

Diabetes 2001

Kinematic approach to gait analysis in patients with rheumatoid arthritis involving the knee joint Reviewed

Michihiro Sakauchi, Katsuhiko Narushima, Hirohito Sone, Yutaka Kamimaki, Yuichiro Yamazaki, Shinjiro Kato, Takashi Takita, Norihiro Suzuki, Kimio Moro

Arthritis Care and Research 45 ( 1 ) 35 - 41 2001

Effects of life style modification on patients with type 2 diabetes: The Japan Diabetes Complications Study (JDCStudy)

Hirohito Sone

Diabetes 2000

Increased mutant frequency and altered mutation spectrum of the lacI transgene in Wilson disease rats with hepatitis

Hirohito Sone

Cancer Research 2000

Vascular endothelial GLUT1 overexpression activates multiple signal transduction pathways

Hirohito Sone

Diabetes 1999

Glucose-mediated regulation of glucose transport and GLUT1 expression in different retinal cells in culture

Hirohito Sone

Diabetes 1999

Vascular endothelial growth factor levels in the aqueous and serum in diabetic retinopathy with or without neovascular glaucoma Reviewed

Tadahiko Kozawa, Hirohito Sone, Yukichi Okuda, Yasushi Kawakami, Yasuo Sekine, Masayuki Imai, Sachiko Hommura, Makoto Inatomi, Shigeo Yaguchi, Katsuhiko Matsuo, Toshiaki Segawa, Hideo Suzuki, Kamejiro Yamashita

Journal of Japanese Ophthalmological Society 102 ( 11 ) 731 - 738 1998.11

Vascular endothelial growth factor (VEGF) enhances glucose transport in retinal endothelial cells through upregulation of GLUT1 glucose transporter

Hirohito Sone

Diabetes 1998

Change in the expression of vascular endothelial growth factor (VEGF) by swimming

Hirohito Sone

Diabetes 1998

Evaluation of α1-adrenoceptor antagonist and antioxidant therapy on diabetes-induced changes in retinal NAD(P)-redox status:: Evidence against "pseudohypoxia?"

Hirohito Sone

Diabetes 1998

Non-invasive ultrasonic analysis of femoral artery wall in patients with NIDDM: Evaluation of early arteriosclerotic lesions and relationship between diabetic neuropathy

Hirohito Sone

Diabetes 1997

Effects of pancreatic hormones and vasoactivators on vascular endothelial growth factor production of human vascular smooth muscle cells

Hirohito Sone

Diabetes 1997

Modulation of vascular endothelial growth factor (VEGF) in animal models of diabetic retinopathy: Future implications

Hirohito Sone

Diabetes 1997

Acute glucose deprivation and progesterone induce vascular endothelial growth factor on retinal pigment epithelial cells

Hirohito Sone

Diabetes 1996

Non-invasive evaluation of lower limb circulation in non-insulin dependent diabetic patients

Hirohito Sone

Diabetes 1996

Radioiodinated metaiodo-benzylguanidine scintigraphy for pheochromocytoma Reviewed

Hirohito Sone, Yukichi Okuda, Yasushi Nakamura, Nobuyoshi Ishikawa, Takashi Yamaoka, Yasushi Kawakami, Masato Odawara, Teruhiko Matsushima, Koichi Kawai, Kamejiro Yamashita

Hormone Research in Paediatrics 46 ( 3 ) 138 - 142 1996

Study of vegf/vpf levels in diabetic proliferative retinopathy and nephropathy

Hirohito Sone

Diabetes 1995

Transient nephrogenic diabetes insipidus accompanied by possible psychogenic polydipsia Reviewed

Hirohito Sone, Koichi Kawai, Masaaki Nishi, Shuya Shimakura, Chieko Bannai, Yasushi Kawakami, Masato Odawara, Teruhiko Matsushima, Yukichi Okuda, Kamejiro Yamashita

Hormone Research in Paediatrics 44 ( 4 ) 193 - 196 1995

Effect of tzp-4238 on bone-mineral content and strength of osteoporotic rats

Hirohito Sone

Calcified Tissue International 1994

A case of diabetic neuropathy treated with selective thrombin inhibitor (argatroban)

Y. Tsurushima, Y. Okuda, S. Suzuki, Y. Asakura, K. Tada, M. Mizutani, M. Ogawa, H. Sone, M. Asano, C. Bannai, Y. Kawakami, M. Odawara, T. Matsushima, K. Kawai, K. Yamashita

Therapeutic Research 15 ( 12 ) 535 - 538 1994

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