Faculty Profiles - SONE, Hirohito

Papers - SONE, Hirohito

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Analysis of the Japanese gestational diabetes mellitus diagnostic strategy during the coronavirus disease 2019 pandemic using DREAMBee study data

Yoshifumi Kasuga, Kei Miyakoshi, Maki Yokoyama, Noriyuki Iwama, Raishi Ichikawa, Hiroshi Yamashita, Ichiro Yasuhi, Asami Ito, Hirohito Sone, Atsuko Abiko, Shinichi Harashima, Maki Kawasaki, Naoko Arata, Shiori Sato, Yuko Iimura, Masako Waguri, Haruna Kawaguchi, Naoki Masaoka, Yoshiyuki Nakajima, Yuji Hiramatsu, Takashi Sugiyama

Journal of Diabetes Investigation 2025.6

Association of bodyweight loss with changes in lipids, blood pressure, and fasting serum glucose following tirzepatide treatment in Japanese participants with type 2 diabetes: A post hoc analysis of the SURPASS J‐mono trial

Hanaka Mimura, Tomonori Oura, Rina Chin, Masakazu Takeuchi, Kazuya Fujihara, Hirohito Sone

Journal of Diabetes Investigation 2025.5

Japan Diabetes Complications Study: Revisiting one of the first large‐scale clinical studies in East Asians with diabetes

Hirohito Sone, Chika Horikawa, Sachiko Tanaka‐Mizuno, Ryo Kawasaki, Kazuya Fujihara, Tatsumi Moriya, Atsushi Araki, Shiro Tanaka, Yasuo Akanuma

Journal of Diabetes Investigation 2025.3

The Relationship Between Triglycerides and Coronary Artery Disease Stratified by Sex and High‐Density Lipoprotein Cholesterol in Men and Women

Momoko Oe, Kazuya Fujihara, Kenichiro Ikeda, Chihiro Shimayama, Takaaki Sato, Taeko Osawa, Yasuhiro Matsubayashi, Satoru Kodama, Takaho Yamada, Hirohito Sone

Diabetes/Metabolism Research and Reviews 2026.3

Osthole Activates FGF21 Expression by Mediating Activation of ATF4 in Human Hepatocyte HepG2 Cells

Akishi Taguchi, Masaya Araki, Tomoya Yamashita, Ryo Kanazawa, Itsuki Terao, Kyohei Suzuki, Yuhei Tsuchimoto, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano, Yoshimi Nakagawa

International Journal of Molecular Sciences 2026.1

Dietary fiber density as an important modifying factor in the association between rice intake and obesity in Japanese type 2 diabetes outpatients: a sex and age-stratified cross-sectional investigation (JDDM 80)

Efrem D'avila Ferreira, Mariko Hatta, Laymon Khin, Izumi Ikeda, Mizuki Takeuchi, Yasunaga Takeda, Sakiko Yoshizawa Morikawa, Chika Horikawa, Noriko Kato, Hiroshi Maegawa, Kazuya Fujihara, Hirohito Sone

Endocrine journal 2025.11

Periodontitis and Mild Cognitive Impairment Risk in Diabetic Patients: Insights from an Exploratory Analysis

Aulia Ramadhani, Kumiko Minagawa, Sachiko Takehara, Noboru Kaneko, Takaho Yamada, Masaru Kitazawa, Hirohito Sone, Yusran Ady Fitrah, Kaname Nohno, Hiroshi Ogawa

Dentistry Journal 2025.11

Inhibition of ELOVL6 activity impairs mitochondrial respiratory function and inhibits tumor progression in FGFR3-mutated bladder cancer cells

Erika Matsuda, Shiho Hasebe, Takashi Matsuzaka, Akio Hayashi, Hiroshi Ohno, Kaori Motomura, Shotaro Sakka, Susumu Kohno, Hayato Muranaka, Minako Yamamura, Asuka Suzuki, Yoshinori Takeuchi, Yoshinori Osaki, Takafumi Miyamoto, Motohiro Sekiya, Hirohito Sone, Naoya Yahagi, Yoshimi Nakagawa, Satoshi Nitta, Shuya Kandori, Takahiro Kojima, Chiaki Takahashi, Hiroyuki Nishiyama, Hitoshi Shimano

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1871 ( 8 ) 168023 - 168023 2025.11

Combination of imeglimin and resistance exercise improves mitochondrial function and glucose metabolism in skeletal muscles. International journal

Hajime Ishiguro, Keitaro Minato, Keiya Iwaasa, Sijia Wu, Guo Antao, Takumu Tsuchida, Tatsuya Suwabe, Takayuki Katagiri, Hiroshi Suzuki, Masayoshi Masuko, Ken-Ichi Watanabe, Takashi Ushiki, Hirohito Sone

Journal of diabetes and its complications 39 ( 10 ) 109145 - 109145 2025.10

Language：English Publishing type：Research paper (scientific journal)

The diabetes medication imeglimin, which operates through a novel mechanism of action and resistance training (RT), a significant exercise therapy, effectively enhances mitochondrial function in skeletal muscles and regulates blood glucose levels. However, the efficacy of the combination therapy remains unclear. The combination of imeglimin and RT enhanced mitochondrial function, reduced inflammatory cytokine levels, and upregulated the expression of anti-inflammatory and antioxidant-related genes as determined by RT-PCR. Additionally, there was an increase in the protein expression of peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC1-α), a crucial regulator of mitochondrial biogenesis and glucose metabolism. This was accompanied by elevated levels of sirtuins (Sirt) 1 and 3, which positively regulate PGC1-α activity, as well as an increase in nicotinamide adenine dinucleotide (NAD+) levels, which are involved in Sirt1 and Sirt3 activity. Furthermore, an increase in the phosphorylation rate of protein kinase B (Akt), which plays a role in insulin signaling, and upregulation of glucose transporter type 4 (GLUT4), which is involved in glucose uptake, were observed. These findings suggest that the combination of imeglimin and RT is a promising therapeutic approach to enhance mitochondrial function and glucose metabolic capacity.

DOI： 10.1016/j.jdiacomp.2025.109145

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Combating the Problems of the Necessity of Continuous Learning in Medical Datasets of Type 2 Diabetes

Jenny Price, Tatsuya Yamazaki, Kazuya Fujihara, Hirohito Sone

Engineering Proceedings 2025.9

【健康食品・サプリメントによる健康被害を防ぐ】国内外のデータベースからみた健康食品の重症健康被害の実態

鈴木浩史, 曽根博仁

医学のあゆみ 294 ( 12 ) 1141 - 1147 2025.9

The associations of body mass index and waist circumference with the risk of diabetic complications in people with type 2 diabetes mellitus. International journal

Megumi Nokihara, Kazuya Fujihara, Yuta Yaguchi, Hiroki Takizawa, Laymon Khin, Efrem D' Avila Ferreira, Takaaki Sato, Chika Horikawa, Masaru Kitazawa, Yasuhiro Matsubayashi, Satoru Kodama, Hirohito Sone

Diabetes, obesity & metabolism 27 ( 8 ) 4259 - 4267 2025.8

Language：English Publishing type：Research paper (scientific journal)

AIMS: To determine the associations of body mass index (BMI) and waist circumference (WC) with severe diabetic complications in patients with type 2 diabetes. MATERIALS AND METHODS: In total, 114 254 participants with type 2 diabetes (82% male; mean age, 52.52 ± 8.27 years; median follow-up, 4.64 years) were enrolled from a nationwide Japanese medical claims database. Cox proportional models with multivariate adjustment were used to assess the associations of BMI and WC with treatment-requiring diabetic eye disease (TRDED), initiation of dialysis, coronary artery disease (CAD), cerebrovascular disease (CVD), heart failure (HF) and amputation. RESULTS: BMI was inversely associated with TRDED, especially in women. Men with WC ≥ 95 cm had a significantly lower risk of TRDED (hazard ratio [HR] = 0.79, 95% CI = 0.69-0.91). Dialysis initiation displayed L-shaped associations with BMI and WC. The risk of CAD was significantly reduced among men with BMI < 20.0 kg/m2 (HR = 0.68, 95% CI = 0.49-0.94). HF had U-shaped associations with BMI and WC. Abdominal obesity increased CVD risk (HR = 1.36, 95% CI = 1.08-1.70). BMI ≥ 25 kg/m2/WC ≥ 90 cm significantly reduced the risk of dialysis (HR = 0.42, 95% CI = 0.29-0.62) and increased the risk of HF (HR = 1.33, 95% CI = 1.03-1.72). CONCLUSIONS: BMI/WC had both positive and negative associations with diabetic complications. Therefore, each patient's BMI/WC target should be carefully determined for each diabetic complication, considering the risk of developing other diseases.

DOI： 10.1111/dom.16461

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出産後75g経口ブドウ糖負荷試験1時間値のみ高値例の検討

山田貴穂, 柳生田紀子, 菅井駿也, 宗田聡, 倉林工, 谷内洋子, 児玉暁, 西島浩二, 吉原弘祐, 曽根博仁

糖尿病と妊娠 25 ( 2 ) S - 80 2025.8

妊娠糖尿病の非妊娠時のbody mass indexが周産期予後に与える影響

柳生田紀子, 山田貴穂, 菅井駿也, 谷内洋子, 児玉暁, 吉原弘祐, 西島浩二, 曽根博仁

糖尿病と妊娠 25 ( 2 ) S - 83 2025.8

Comparison of the ability to diagnose gestational diabetes mellitus between glycated albumin or fructosamine and hemoglobin A1c-a meta-analysis of diagnostic studies. International journal

Satoru Kodama, Takaho Yamada, Noriko Yagyuda, Nanako Tanaka, Sijia Wu, Efrem D'Avila Ferreira, Khin Laymon, Kazuya Fujihara, Chika Horikawa, Yoko Yachi, Hirohito Sone

Systematic reviews 14 ( 1 ) 144 - 144 2025.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: While the oral glucose tolerance test (OGTT) is the gold standard for diagnosing gestational diabetes mellitus (GDM), hemoglobin A1c (A1C), glycated albumin (GA), and fructosamine (Fruc) have the potential to conveniently classify pregnant women as having or not having GDM because two or more measurements are not necessary, unlike with OGTT. Compared with A1C, GA or Fruc, which reflects more recent glycemic indices, may more accurately detect GDM. This meta-analysis compared the diagnostic ability of GDM between GA or Fruc and A1C. METHOD: Comprehensive literature searches were performed for studies published up to Sep.11, 2023. Selected studies were limited to those that attempted to identify GDM using both GA and/or Fruc and A1C to compare these indicators. Two authors extracted the data. Disagreements were resolved by a third author. Study quality was assessed by a revised tool for quality assessment of diagnostic accuracy in studies (QUADUS-2). The dataset consisting of true-positives, false-positives, false-negatives, and true-negatives was pooled with a bivariate between-study model and hierarchical summary receiver operating characteristic model. Pooled relative sensitivity and specificity based on a random-effects model were calculated to compare the diagnostic ability of A1C and GA and/or Fruc for GDM. RESULT: There were 20 eligible studies. Pooled positive and negative likelihood ratios with 95% confidence intervals (CI) were 5.11 (2.30-11.37) and 0.53 (0.40-0.71), respectively, if GA or Fruc was used and 3.75 (2.61-11.39) and 0.53 (0.42-0.66), respectively, if A1C was used. Relative sensitivity and specificity (95% CI) for GA or Fruc compared with A1C was 1.00 (0.94-1.07) and 0.99 (0.97-1.01), respectively. CONCLUSION: The insufficiently low value of the negative likelihood ratio did not support the single use of GA/Fruc or A1C in screening for GDM suggesting the necessity of combining other risk factors with glycemic indicators. Although there was no statistically significant difference in diagnostic ability between GA or Fruc and A1C, the value of the positive likelihood ratio indicated that GA or Fruc was somewhat more useful than A1C as a rule-in test for the diagnosis of GDM. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42023461975.

DOI： 10.1186/s13643-025-02894-0

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Fatal SARS-CoV-2 Reactivation After Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia

Yuri Furuyama, Tatsuya Suwabe, Ayako Kawakami, Hodaka Yonezawa, Takayuki Katagiri, Kyoko Fuse, Yasuhiko Shibasaki, Takashi Ushiki, Jun Takizawa, Hirohito Sone, Masayoshi Masuko

Cureus 2025.7

授乳による血糖変動と疲労感の関連月齢5ヵ月児を育てる母親の1例報告

柳生田紀子, 松林泰弘, 小原慶子, 山田貴穂, 曽根博仁

新潟周産母子研究会学術講演会 35回 7 - 7 2025.7

DDAVP点鼻の自己調節により急性代謝失調が回避された頭蓋咽頭腫術後・初発糖尿病の1例

木村智佑, 丹野貴文, 滝澤大輝, 佐藤隆明, 鈴木浩史, 松林泰弘, 藤原和哉, 山田貴穂, 曽根博仁

糖尿病 68 ( 7 ) 290 - 290 2025.7

SGLT2阻害薬の内服を契機に糖尿病性ケトアシドーシスを発症した1例

磯貝真理恵, 高澤遥子, 村井幸四郎, 北澤勝, 鈴木浩史, 松林泰弘, 藤原和哉, 山田貴穂, 曽根博仁

糖尿病 68 ( 7 ) 308 - 308 2025.7

Exploring the Changes in Mild Cognitive Impairment Blood-Based Biomarkers after Local Antibiotic Periodontal Treatment in Diabetic Patients: Secondary Analysis of Data from a Randomized Controlled Trial. International journal

Aulia Ramadhani, Azusa Tanaka, Kumiko Minagawa, Sachiko Takehara, Takaho Yamada, Hirohito Sone, Noboru Kaneko, Kaname Nohno, Hiroshi Ogawa

European journal of dentistry 19 ( 3 ) 749 - 757 2025.7

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: This article investigates the changes in blood-based biomarkers associated with mild cognitive impairment (MCI) risk in type 2 diabetic patients following local antibiotic periodontal treatment. MATERIALS AND METHODS: A secondary analysis of data from a 24-week randomized controlled trial was conducted, involving 27 patients with type 2 diabetes mellitus and periodontitis. Participants received periodontal treatment biweekly from baseline until the 6th week of the study. Fourteen patients in intervention group received scaling with local antibiotic adjunct (Periofol 2%). The outcomes were periodontal inflammation score, which was measured using periodontal inflamed surface area, the inflammation markers levels (tumor necrosis factor-α, C-reactive protein, and interleukin [IL]-6), and MCI risk score, which was assessed using protein plasma analysis through blood test. The evaluations were performed at baseline and week 24th in both groups. The changes in periodontal inflammation scores, inflammation parameters, and MCI risk in baseline and week 24th were analyzed. STATISTICAL ANALYSIS: The Wilcoxon signed-rank test was used for within-group analysis and the Mann-Whitney U test was utilized for between-group analysis. RESULTS: Periodontal parameters were improved in both groups (p < 0.05). IL-6, complement C3, and alpha-2-antiplasmin levels were significantly decreased in the intervention group (p < 0.05). In between-group comparisons, there was a significant difference between the control and intervention groups in apolipoprotein A1, apolipoprotein C1, and alpha-1-B glycoprotein levels in week 24th (p < 0.05). CONCLUSION: Even though the periodontal status showed significant improvement after being given local antibiotic periodontal treatment, the changes in MCI risk proteins plasma remained unclear.

DOI： 10.1055/s-0044-1795115

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Papers - SONE, Hirohito