Updated on 2025/05/04

写真a

 
OBATA Hiroaki
 
Organization
Graduate School of Medical and Dental Sciences Specially Appointed Associate Professor
Title
Specially Appointed Associate Professor
External link

Degree

  • 博士（医学） ( 2008.3 )

Research History

  • Niigata University   Graduate School of Medical and Dental Sciences   Specially Appointed Associate Professor

    2024.4

  • Niigata University   University Medical and Dental Hospital Cardiovascular Medicine   Specially Appointed Assistant Professor

    2013.4 - 2024.3

 

Papers

  • Impact and management of integrated dysphagia rehabilitation within cardiac care programs for older patients with cardiovascular disease Reviewed

    Hiroaki Obata, Tohru Izumi, Mitsuo Ishizuka, Kenji Yamaguchi, Naohito Hao, Nobue Yagihara, Satoru Abe, Hiroshi Watanabe, Takayuki Inomata, Shigeru Makita, Shigeru Fujimoto

    European Geriatric Medicine   2024.8

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Purpose

    This study assessed the characteristics, management, and outcomes of dysphagia rehabilitation in older patients with CVD in a super-aged society, highlighting the need for comprehensive management strategies in community hospital settings. It aimed to uncover valuable insights into the benefits of integrating dysphagia rehabilitation with cardiac care in patient management.

    Methods

    We conducted a retrospective review of patients with CVD aged ≥ 65 years who were admitted to Niigata Minami Hospital between January 2019 and December 2021. We focused on patients requiring dysphagia rehabilitation and assessing the effects of these interventions on recovery.

    Results

    The study included 732 participants with an average age of 86.0 ± 7.8 years, of whom 41.9% were male. Approximately 55.1% required dysphagia rehabilitation. Dysphagia rehabilitation significantly improved oral caloric intake and BMI in patients who underwent rehabilitation, and these improvements were comparable to those in patients who did not require dysphagia rehabilitation. Significant enhancement in the ADL of patients was observed at discharge. Patients who required dysphagia rehabilitation also had longer hospital stays and were more likely to be discharged to nursing facilities.

    Conclusion

    Dysphagia is common in older patients with CVD, and dysphagia rehabilitation positively affects the maintenance of nutritional status and helps patients achieve ADL independence at discharge. This study highlights the importance of integrating dysphagia rehabilitation into ordinary cardiac rehabilitation programs for older patients with CVD to improve their QOL.

    DOI： 10.1007/s41999-024-01031-9

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    Other Link： https://link.springer.com/article/10.1007/s41999-024-01031-9/fulltext.html

  • Overlapping states of AWGS muscle dysfunction and inverse feasibility of ADL recovery by rehabilitation in older inpatients Reviewed

    Masashi Yamashita, Hiroaki Obata, Kentaro Kamiya, Atsuhiko Matsunaga, Kazuki Hotta, Tohru Izumi

    Scientific Reports   12 ( 1 )   2022.12

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Rehabilitation based on guided walking is effective to recover activity of daily living (ADL) in frail older adults, even octogenarians. However, muscle dysfunction obviously reflects disability, and few studies have focused on ADL recovery by rehabilitation. We employed the state of muscle dysfunctions proposed by the Asian Working Group for Sarcopenia (AWGS) in 2019 and attempted to clarify the relation between the overlapping dysfunctions and the feasibility of ADL recovery after rehabilitation. In total, 297 frail older patients (the mean age: 82.8 years, 46.1% of patients were male) participated in a walking-guided rehabilitation program to achieve the goal of ambulatory discharge. Muscle dysfunction was categorized by four standardized methods at the start of rehabilitation (grip strength, gait speed, time of five sit-to-stand, and short physical performance battery: SPPB), according to the AWGS proposal. ADLs were monitored by Barthel index before admission, at the start of rehabilitation, and at discharge. At least one dysfunction was present in 95.3% of patients. If a single patient had three or more muscle dysfunction, the ADLs recovery was significantly limited (interaction: p < 0.05). The overlapped counts of AWGS muscle dysfunction helps to predict inverse feasibility of ADL recovery in frail older patients through rehabilitation.

    DOI： 10.1038/s41598-022-26622-z

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    Other Link： https://www.nature.com/articles/s41598-022-26622-z

  • JCS/JACR 2021 Guideline on Rehabilitation in Patients With Cardiovascular Disease

    Shigeru Makita, Takanori Yasu, Yoshihiro J Akashi, Hitoshi Adachi, Hideo Izawa, Shunichi Ishihara, Yoshitaka Iso, Hideo Ohuchi, Kazuto Omiya, Yusuke Ohya, Koichi Okita, Yutaka Kimura, Akira Koike, Masahiro Kohzuki, Shinji Koba, Masataka Sata, Kazunori Shimada, Tomoki Shimokawa, Hirokazu Shiraishi, Naokata Sumitomo, Tetsuya Takahashi, Tomoyuki Takura, Hiroyuki Tsutsui, Masatoshi Nagayama, Emiko Hasegawa, Yoshihiro Fukumoto, Yutaka Furukawa, Shin-ichiro Miura, Satoshi Yasuda, Sumio Yamada, Yuichiro Yamada, Dai Yumino, Toshiko Yoshida, Takuji Adachi, Toshimi Ikegame, Kazuhiro P Izawa, Takeshi Ishida, Neiko Ozasa, Naohiko Osada, Hiroaki Obata, Naoya Kakutani, Yusuke Kasahara, Masaaki Kato, Kentaro Kamiya, Shintaro Kinugawa, Yuji Kono, Yasuyuki Kobayashi, Teruyuki Koyama, Kazuhiro Sase, Shinji Sato, Tatsuhiro Shibata, Norio Suzuki, Daisuke Tamaki, Minako Yamaoka-Tojo, Michio Nakanishi, Eisaku Nakane, Mari Nishizaki, Taiki Higo, Kanta Fujimi, Tasuku Honda, Yasuharu Matsumoto, Noriko Matsumoto, Ikuko Miyawaki, Makoto Murata, Shusuke Yagi, Masanobu Yanase, Midori Yamada, Miho Yokoyama, Noboru Watanabe, Haruki Ito, Takeshi Kimura, Syunei Kyo, Yoichi Goto, Ryuji Nohara, Ken-Ichi Hirata

    Circulation Journal   87 ( 1 )   155 - 235   2022.12

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    Publishing type：Research paper (scientific journal)   Publisher：Japanese Circulation Society  

    DOI： 10.1253/circj.cj-22-0234

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  • Characteristics of Elderly Patients with Heart Failure and Impact on Activities of Daily Living: A Registry Report from Super-Aged Society Reviewed

    Hiroaki Obata, Tohru Izumi, Masashi Yamashita, Wataru Mitsuma, Keisuke Suzuki, Shinichi Noto, Takeshi Morimoto, Mitsuaki Isobe

    Journal of Cardiac Failure   27 ( 11 )   1203 - 1213   2021.11

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.cardfail.2021.05.008

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  • The baseline speed of 10-m gait predicts ambulatory discharge for hospitalized frail elderly after DOPPO rehabilitation Reviewed

    Akifumi Uehara, Hiroaki Obata, Hiroshi Watanabe, Yuki Izumi, Yorio Suzuki, Tohru Izumi

    International Journal of Rehabilitation Research   41 ( 4 )   331 - 336   2018.12

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Ovid Technologies (Wolters Kluwer Health)  

    The discharge of elderly patients from hospital on the basis of their independent gait program (DOPPO) is a new rehabilitation strategy for physically frail hospitalized elderly that aims to recover independent gait and to achieve ambulatory discharge. We retrospectively investigated baseline determinants of physical measures associated closely with the 6-min walking distance (6MWD) after DOPPO. Participants were 137 consecutive elderly inpatients, irrespective of the causative disease (mean age: 82±7 years; 76 women), who had a Short Physical Performance Battery (SPPB) score of less than 12 and low independent walking capacity. The rehabilitation comprised muscle stretching, muscle strengthening, balance training, and endurance exercise, including walking. The exercises were gradually increased until the goal of ambulatory discharge was attained. The SPPB, isometric knee-extension muscle strength (IKEMS), functional reach test (FRT), one-leg stance time (OLST), and the 10-m gait speed (TMGS) were measured, before and after the DOPPO intervention, and their association with the 6MWD was evaluated. All participants achieved ambulatory discharge, requiring on average 35±19 hospital days and 32±18 h of rehabilitation. The SPPB, IKEMS, FRT, OLST, and TMGS improved. The SPPB scores increased from 7.1 at baseline to 9.2 at discharge. Eighty-eight patients completed the 6MWD. The SPPB, IKEMS, FRT, OLST, and TMGS were strongly associated with the 6MWD. Only the baseline TMGS and SPPB predicted the 6MWD, with a cut-off TMGS value of 0.84 m/s providing the best prediction of achieving a distance of more than 300 m on the 6MWD. Thus, the baseline TMGS is the best prediction of the ambulatory outcome after the present DOPPO rehabilitation.

    DOI： 10.1097/mrr.0000000000000308

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  • Single Injection of a Sustained-release Prostacyclin Analog Improves Pulmonary Hypertension in Rats Reviewed

    Hiroaki Obata, Yoshiki Sakai, Shunsuke Ohnishi, Satoshi Takeshita, Hidezo Mori, Makoto Kodama, Kenji Kangawa, Yoshifusa Aizawa, Noritoshi Nagaya

    American Journal of Respiratory and Critical Care Medicine   177 ( 2 )   195 - 201   2008.1

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：American Thoracic Society  

    DOI： 10.1164/rccm.200703-349oc

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  • Adipokines in patients with heart failure under rehabilitation Reviewed

    Shinya Fujiki, Hiroshi Watanabe, Hiroaki Obata, Masayoshi Suda, Wataru Mitsuma, Asako Tomii, Katsuyuki Sakai, Akifumi Uehara, Ippei Shimizu, Takeshi Kashimura, Kazuyuki Ozaki, Tohru Minamino

    Acta Biomedica   92 ( 3 )   2021.7

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Mattioli 1885  

    Background Frailty is a multifactorial physiological syndrome most often associated with age but which has received increasing recognition as a component of chronic illnesses such as heart failure. Patients with heart failure are likely to be frail, irrespective of their age. Adipokine dysregulation, which is associated with frailty, occurs in patients with heart failure. In this study, we tested the hypothesis that adipokines are associated with skeletal muscle and bone mineral density that change lead to frailty in patients with heart failure. Methods Thirty-five patients with heart failure (age, 67 ± 14 years
    25 males
    left ventricular ejection fraction, 45 ± 19%) were included. Serum adipokine levels, physical performance, and body composition were measured. Results Adiponectin and leptin were inversely correlated with grip strength. Adiponectin was inversely correlated with bone mineral density. Leptin was positively correlated with fat mass. Adipokines were not correlated with skeletal muscle mass. Conclusions Adipokines were associated with grip strength and bone mineral density in patients with heart failure. Adipokine dysregulation may play a role in the development of frailty in heart failure.

    DOI： 10.23750/abm.v92i3.9228

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  • Association of adipokines with frailty in heart failure. International journal

    Shinya Fujiki, Hiroshi Watanabe, Hiroaki Obata, Masayoshi Suda, Wataru Mitsuma, Asako Tomii, Katsuyuki Sakai, Akifumi Uehara, Ippei Shimizu, Takeshi Kashimura, Kazuyuki Ozaki, Tohru Minamino

    Acta bio-medica : Atenei Parmensis   92 ( 3 )   e2021195   2021.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    Background Frailty is a multifactorial physiological syndrome most often associated with age but which has received increasing recognition as a component of chronic illnesses such as heart failure. Patients with heart failure are likely to be frail, irrespective of their age. Adipokine dysregulation, which is associated with frailty, occurs in patients with heart failure. In this study, we tested the hypothesis that adipokines are associated with frailty in patients with heart failure. Methods Thirty-five patients with heart failure (age, 67 ± 14 years; 25 males; left ventricular ejection fraction, 45 ± 19%) were included. Serum adipokine levels, physical performance, and body composition were measured. Results Adiponectin and leptin were inversely correlated with grip strength. Adiponectin was inversely correlated with bone mineral density. Leptin was positively correlated with fat mass. Adipokines were not correlated with skeletal muscle mass. Conclusions Adipokines were associated with frailty in patients with heart failure. Adipokine dysregulation may play a role in the development of frailty in heart failure.

    DOI： 10.23750/abm.v92i3.9228

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  • Diastolic Wall Strain Predicts Clinical Worsening of Fulminant Myocarditis: Exploratory Findings from Four Case Reports Reviewed

    Shinya Fujiki, Hiroaki Obata, Takeshi Kashimura, Komei Tanaka, Haruo Hanawa, Tohru Minamino

    JOURNAL OF CARDIAC FAILURE   21 ( 10 )   S164 - S165   2015.10

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    Language：English   Publisher：CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS  

    DOI： 10.1016/j.cardfail.2015.08.120

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  • Systemic Reactions in Patients with Isolated Cardiac Sarcoidosis Reviewed

    Takeshi Kashimura, Tohru Watanabe, Hiroaki Obata, Haruo Hanawa, Tohru Minamino

    JOURNAL OF CARDIAC FAILURE   20 ( 10 )   S156 - S156   2014.10

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    Language：English   Publisher：CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS  

    DOI： 10.1016/j.cardfail.2014.07.145

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  • Acute Hemodynamic Effects of Adaptive Servo Ventilation in a Patient with Atrial Septal Defect Reviewed

    Shinya Fujiki, Hiroaki Obata, Takeshi Kashimura, Ritsuo Watanabe, Osamu Ogawa, Haruo Hanawa, Tohru Minamino

    JOURNAL OF CARDIAC FAILURE   20 ( 10 )   S210 - S210   2014.10

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    Language：English   Publisher：CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS  

    DOI： 10.1016/j.cardfail.2014.07.428

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  • Characteristics of Sarcopenia in Patients with Heart Failure Reviewed

    Hiroaki Obata, Toru Izumi, Wataru Mitsuma, Asako Tomii, Katsuyuki Sakai, Akifumi Uehara, Tohru Watanabe, Takeshi Kashimura, Haruo Hanawa, Tohru Minamino

    JOURNAL OF CARDIAC FAILURE   20 ( 10 )   S160 - S160   2014.10

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    Language：English   Publisher：CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS  

    DOI： 10.1016/j.cardfail.2014.07.171

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  • 1. Up-to-date on Drug Therapy for Chronic Heart Failure

    Hiroaki Obata, Tohru Minamino

    Nihon Naika Gakkai Zasshi   103 ( 2 )   378 - 386   2014

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Internal Medicine  

    DOI： 10.2169/naika.103.378

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  • A Case of Chronic Lupus Myocarditis Reviewed

    Takayuki Wakasugi, Hiroaki Obata, Go Hasegawa, Takeshi Kashimura, Haruo Hanawa, Tohru Minamino

    JOURNAL OF CARDIAC FAILURE   19 ( 10 )   S159 - S159   2013.10

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    Language：English   Publisher：CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS  

    DOI： 10.1016/j.cardfail.2013.08.412

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  • The Usefulness of Endomyocardial Biopsy in Patients with Left Ventricular Dysfunction Reviewed

    Hiromi Kayamori, Tohru Watanabe, Takeshi Kashimura, Hiroaki Obata, Haruo Hanawa, Tohru Minamino

    JOURNAL OF CARDIAC FAILURE   19 ( 10 )   S148 - S148   2013.10

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    Language：English   Publisher：CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS  

    DOI： 10.1016/j.cardfail.2013.08.244

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  • Characteristics of Patient with Ventricular Fibrillation in Takotsubo Cardiomyopathy Reviewed

    Shinya Fujiki, Hiroaki Obata, Takeshi Kashimura, Tadashi Sato, Kenji Ojima, Haruo Hanawa, Tohru Minamino

    JOURNAL OF CARDIAC FAILURE   19 ( 10 )   S164 - S165   2013.10

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    Language：English   Publisher：CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS  

    DOI： 10.1016/j.cardfail.2013.08.442

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  • Mechanical alternans in human idiopathic dilated cardiomyopathy is caused with impaired force-frequency relationship and enhanced poststimulation potentiation. Reviewed

    Takeshi Kashimura, Makoto Kodama, Komei Tanaka, Keiko Sonoda, Satoru Watanabe, Yukako Ohno, Makoto Tomita, Hiroaki Obata, Wataru Mitsuma, Masahiro Ito, Satoru Hirono, Haruo Hanawa, Yoshifusa Aizawa

    Heart and vessels   28 ( 3 )   336 - 44   2013.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    Mechanical alternans (MA) is frequently observed in patients with heart failure, and is a predictor of cardiac events. However, there have been controversies regarding the conditions and mechanisms of MA. To clarify heart rate-dependent contractile properties related to MA, we performed incremental right atrial pacing in 17 idiopathic dilated cardiomyopathy (DCM) patients and in six control patients. The maximal increase in left ventricular dP/dt during pacing-induced tachycardia was assessed as the force gain in the force-frequency relationship (FG-FFR), and the maximal increase in left ventricular dP/dt of the first post-pacing beats was examined as the force gain in poststimulation potentiation (FG-PSP). As a result, MA was induced in 9 DCM patients (DCM MA(+)) but not in the other 8 DCM patients (DCM MA(-)), and not in any of the control patients. DCM MA(+) had significantly lower FG-FFR (34.7 ± 40.9 vs 159.4 ± 103.9 mmHg/s, P = 0.0091) and higher FG-PSP (500.0 ± 96.8 vs 321.9 ± 94.9 mmHg/s, P = 0.0017), and accordingly a wider gap between FG-PSP and FG-FFR (465.3 ± 119.4 vs 162.5 ± 123.6 mmHg/s, P = 0.0001) than DCM MA(-) patients. These characteristics of DCM MA(+) showed clear contrasts to those of the control patients. In conclusion, MA is caused with an impaired force-frequency relationship despite significant poststimulation potentiation, suggesting that MA reflects ineffective utilization of the potentiated intrinsic force during tachycardia.

    DOI： 10.1007/s00380-012-0251-8

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  • Oral Administration of a Novel Long-Acting Prostacyclin Agonist With Thromboxane Synthase Inhibitory Activity for Pulmonary Arterial Hypertension Reviewed

    Atsuhiro Nakamura, Noritoshi Nagaya, Hiroaki Obata, Katsuya Sakai, Yoshiki Sakai, Masanori Yoshikawa, Kaoru Hamada, Kunio Matsumoto, Hiroshi Kimura

    Circulation Journal   77 ( 8 )   2127 - 2133   2013

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    Publishing type：Research paper (scientific journal)   Publisher：Japanese Circulation Society  

    DOI： 10.1253/circj.cj-13-0107

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  • Comparison of Patients With Pulmonary Arterial Hypertension With Versus Without Right-Sided Mechanical Alternans Reviewed

    Masahiro Ito, Makoto Kodama, Takeshi Kashimura, Hiroaki Obata, Wataru Mitsuma, Satoru Hirono, Makoto Tomita, Yukako Ohno, Naohito Tanabe, Yoshifusa Aizawa

    AMERICAN JOURNAL OF CARDIOLOGY   109 ( 3 )   428 - 431   2012.2

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC  

    The clinical implications of mechanical alternans in patients with pulmonary arterial hypertension (PAH) remain unknown. In this study, the prevalence, characteristics, and prognostic implications of mechanical alternans in patients with PAH were investigated. Thirty-two consecutive patients with PAH confirmed by cardiac catheterization from 2000 to 2010 were included in this cohort study. During cardiac catheterization, 8 patients (25%) showed mechanical alternans at rest. All alternans were detected in the right ventricle and pulmonary trunk. Serum level of brain natriuretic peptide (584 +/- 177 vs 238 +/- 252 pg/ml, p = 0.001), World Health Organization functional class (3.5 +/- 0.5 vs 2.9 +/- 0.4, p = 0.02), mean pulmonary arterial pressure (59 +/- 10 vs 47 +/- 18 mm Hg, p = 0.03), mean right atrial pressure (10 +/- 4 vs 5 +/- 4 ram Hg, p = 0.01), right ventricular end-diastolic pressure (15 +/- 5 vs 9 +/- 5 mm Hg, p = 0.01), and heart rate at catheterization (96 +/- 17 vs 70 +/- 11 beats/min, p = 0.003) were significantly higher in patients with alternans than in those without. Twelve-month mortality of patients with alternans was higher than in patients without alternans (p = 0.03): the 12-month survival rate after cardiac catheterization was 37% for the alternans group and 75% for the group without alternans. In conclusion, isolated right-sided mechanical alternans is not an uncommon event in patients with PAH. The existence of alternans is associated with the severity of PAH and right ventricular dysfunction and implies a poor prognosis in the short term. (C) 2012 Elsevier Inc. All rights reserved. (Am J Cardiol 2012;109:428-431)

    DOI： 10.1016/j.amjcard.2011.09.034

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  • Effects of Combination Therapy With Warfarin and Bucolome for Anticoagulation in Patients With Atrial Fibrillation Reviewed

    Hiroaki Obata, Hiroshi Watanabe, Masahiro Ito, Satoru Hirono, Haruo Hanawa, Makoto Kodama, Yoshifusa Aizawa

    Circulation Journal   75 ( 1 )   201 - 203   2011

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Japanese Circulation Society  

    DOI： 10.1253/circj.cj-10-0842

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  • Sudden Cardiac Arrest after Subarachnoid Hemorrhage Reviewed

    Wataru Mitsuma, Masahiro Ito, Hiroaki Obata, Makoto Kodama

    INTERNAL MEDICINE   50 ( 17 )   1859 - 1859   2011

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    Language：English   Publisher：JAPAN SOC INTERNAL MEDICINE  

    DOI： 10.2169/internalmedicine.50.5704

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  • Nonviral delivery of siRNA into mesenchymal stem cells by a combination of ultrasound and microbubbles Reviewed

    Kentaro Otani, Kenichi Yamahara, Shunsuke Ohnishi, Hiroaki Obata, Soichiro Kitamura, Noritoshi Nagaya

    Journal of Controlled Release   133 ( 2 )   146 - 153   2009.1

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.jconrel.2008.09.088

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  • Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats Reviewed

    Takefumi Itoh, Hiroaki Obata, Shinsuke Murakami, Kaoru Hamada, Kenji Kangawa, Hiroshi Kimura, Noritoshi Nagaya

    American Journal of Physiology-Lung Cellular and Molecular Physiology   293 ( 2 )   L446 - L452   2007.8

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    Publishing type：Research paper (scientific journal)   Publisher：American Physiological Society  

    Adrenomedullin (AM), an endogenous peptide, has been shown to have a variety of protective effects on the cardiovascular system. However, the effect of AM on acute lung injury remains unknown. Accordingly, we investigated whether AM infusion ameliorates lipopolysaccharide (LPS)-induced acute lung injury in rats. Rats were randomized to receive continuous intravenous infusion of AM (0.1 μg·kg<sup>−1</sup>·min<sup>−1</sup>) or vehicle through a microosmotic pump. The animals were intratracheally injected with either LPS (1 mg/kg) or saline. At 6 and 18 h after intratracheal instillation, we performed histological examination and bronchoalveolar lavage and assessed the lung wet/dry weight ratio as an index of acute lung injury. Then we measured the numbers of total cells and neutrophils and the levels of tumor necrosis factor (TNF)-α and cytokine-induced neutrophil chemoattractant (CINC) in bronchoalveolar lavage fluid (BALF). In addition, we evaluated BALF total protein and albumin levels as indexes of lung permeability. LPS instillation caused severe acute lung injury, as indicated by the histological findings and the lung wet/dry weight ratio. However, AM infusion attenuated these LPS-induced abnormalities. AM decreased the numbers of total cells and neutrophils and the levels of TNF-α and CINC in BALF. AM also reduced BALF total protein and albumin levels. In addition, AM significantly suppressed apoptosis of alveolar wall cells as indicated by cleaved caspase-3 staining. In conclusion, continuous infusion of AM ameliorated LPS-induced acute lung injury in rats. This beneficial effect of AM on acute lung injury may be mediated by inhibition of inflammation, hyperpermeability, and alveolar wall cell apoptosis.

    DOI： 10.1152/ajplung.00412.2005

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  • CNP infusion attenuates cardiac dysfunction and inflammation in myocarditis Reviewed

    Hiroaki Obata, Bobby Yanagawa, Koichi Tanaka, Shunsuke Ohnishi, Masaharu Kataoka, Yoshinori Miyahara, Hatsue Ishibashi-Ueda, Makoto Kodama, Yoshifusa Aizawa, Kenji Kangawa, Noritoshi Nagaya

    Biochemical and Biophysical Research Communications   356 ( 1 )   60 - 66   2007.4

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.bbrc.2007.02.085

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  • Familial amyotrophic lateral sclerosis with bulbar onset and a novel Asp101Tyr Cu/Zn superoxide dismutase gene mutation Reviewed

    Chun-Feng Tan, Yue-Shan Piao, Shintaro Hayashi, Hiroaki Obata, Yoshitaka Umeda, Masahisa Sato, Takao Fukushima, Ryoichi Nakano, Shoji Tsuji, Hitoshi Takahashi

    Acta Neuropathologica   108 ( 4 )   332 - 336   2004.7

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    DOI： 10.1007/s00401-004-0893-4

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    Other Link： http://link.springer.com/article/10.1007/s00401-004-0893-4/fulltext.html

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